Best TWAS P=2.02e-10 · Best GWAS P=1.97e-15 conditioned to 8.38e-12
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Pancreas | NEK6 | 0.40 | 0.26 | lasso | 3 | 0.26 | 1.7e-11 | -5.7 | 5.7 | 1.2e-08 | 0.04 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Thyroid | PSMB7 | 0.06 | 0.04 | lasso | 2 | 0.06 | 4.1e-05 | 5.3 | -5.3 | 1.2e-07 | -0.40 | 0.50 | 0.27 | FALSE |
| 3 | GTEx | Whole Blood | NEK6 | 0.20 | 0.04 | enet | 31 | 0.05 | 8.3e-06 | 4.7 | 6.4 | 2.0e-10 | 0.22 | 0.98 | 0.01 | TRUE |
| 4 | NTR | Blood | NEK6 | 0.13 | 0.08 | bslmm | 401 | 0.09 | 5.0e-28 | -5.9 | 5.5 | 4.1e-08 | 0.06 | 1.00 | 0.00 | FALSE |
| 5 | YFS | Blood | DENND1A | 0.15 | 0.05 | lasso | 10 | 0.10 | 1.7e-29 | 5.3 | -5.6 | 2.5e-08 | 0.02 | 1.00 | 0.00 | TRUE |
| 6 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | NEK6 | 0.14 | 0.02 | blup | 87 | 0.05 | 2.8e-03 | -5.2 | 5.3 | 9.3e-08 | 0.18 | 0.02 | 0.58 | FALSE |