TWAS hub - PHF19

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Gastroesophageal Junction	0.0990	0.0470	3.7e-03	0.017	NA	0.036	NA	0.009	7.8e-02	NA	1.8e-02	NA	1.5e-01
2	GTEx	Esophagus Muscularis	0.1650	0.0500	4.9e-06	0.060	NA	0.059	NA	0.074	1.7e-04	NA	1.9e-04	NA	3.1e-05
3	GTEx	Nerve Tibial	0.0666	0.0342	5.8e-03	0.032	NA	0.009	NA	0.020	2.3e-03	NA	6.6e-02	NA	1.3e-02
4	METSIM	Adipose	0.0671	0.0336	3.9e-04	0.014	0.006	0.001	0.007	0.006	2.9e-03	3.2e-02	1.8e-01	2.3e-02	3.6e-02
5	YFS	Blood	0.0468	0.0150	7.8e-12	0.034	0.039	0.044	0.039	0.044	3.0e-11	6.3e-13	2.9e-14	9.4e-13	3.0e-14
6	TCGA	Prostate Adenocarcinoma	0.0266	0.0162	2.9e-03	0.029	0.013	-0.002	NA	0.019	4.6e-04	1.4e-02	6.3e-01	NA	3.6e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Hayfever, allergic rhinitis or eczema	11.5	24.9	43.8	-3.1	-5.8	-1.3	-4.2	-6.6	-6.5
Rheumatoid Arthritis	9.0	12.3	24.2	-1.9	-4.3	-2.2	-2.5	-4.1	-4.9
Allergy or Eczema	8.2	21.6	41.8	-2.6	-5.6	-0.8	-3.3	-6.2	-6.5
Hypothyroidism (self reported)	7.9	18.2	27.2	-3.1	-4.2	-3.0	-5.2	-5.2	-4.3
Allergy	6.4	14.8	28.3	2.3	4.8	0.9	2.2	5.2	5.3
Pulse rate, automated reading	6.3	20.3	25.7	4.5	4.8	3.7	5.1	4.7	4.2
Osteoarthritis (self-reported)	5.9	7.6	11.9	1.9	3.3	1.9	3.5	2.7	2.9
Suffer from ‘nerves’	5.0	7.8	16.3	0.8	2.9	2.3	4.0	3.0	2.6
Shortness of breath walking on level ground	4.8	5.8	9.4	0.5	3.1	0.8	2.9	2.5	3.0
Hypothyroidism/myxoedema (self-reported)	4.7	9.2	14.2	-2.4	-2.9	-2.4	-3.8	-3.6	-2.8
Blood Platelet Count	4.5	52.4	74.0	5.6	8.6	5.3	8.4	7.9	7.0
Blood White Count	4.3	32.1	53.4	0.7	6.6	2.6	7.0	6.3	7.3
Birth weight	4.0	8.6	28.3	1.2	1.3	0.1	2.8	5.3	3.5
Ever highly irritable/argumentative for 2 days	3.9	4.7	10.1	0.9	3.2	1.1	2.2	2.2	2.5
Leg pain on walking	3.6	4.4	8.0	1.2	2.2	1.6	2.8	2.2	2.2
Depression (Nagel 2018)	3.5	5.2	8.6	1.8	2.6	1.7	2.9	2.3	2.2
Hayfever/allergic rhinitis (self-reported)	3.5	4.6	9.8	-0.9	-2.6	-1.0	-1.4	-3.1	-2.6
Supplements: Vitamin C	3.5	4.1	8.0	1.2	2.5	1.1	2.8	2.2	1.8
Lung cancer (father)	3.4	4.0	9.0	0.1	1.5	0.1	2.0	2.9	3.0
Knee pain experienced in last month	3.4	5.3	9.2	1.1	2.6	2.5	3.0	2.1	1.9
Medication: Co-codamol	3.3	3.9	8.5	0.7	2.5	1.8	2.9	1.2	1.8
Hand grip strength (right)	3.3	9.0	25.3	0.0	-3.3	-3.2	-5.0	-2.2	-1.7
Medication: Bendroflumethiazide	3.3	5.0	8.3	1.6	1.8	2.9	2.4	2.6	1.9
Reaction Time	3.2	6.1	9.5	-3.1	-2.8	-3.1	-1.1	-1.9	-2.2
Breast Cancer	3.2	7.6	13.1	2.9	2.5	2.2	1.8	3.1	3.6
Maternal smoking around birth	3.2	4.7	6.8	1.9	2.6	1.2	2.5	2.0	2.4
Migraine (self-reported)	3.2	4.0	7.5	1.9	2.7	1.4	1.9	1.2	2.4
Pain experienced in last month	3.2	5.4	10.7	-0.9	-3.0	-2.2	-3.3	-2.0	-1.8
Medication: Omeprazole (e.g. Zanprol)	3.0	3.6	6.2	1.3	2.5	1.0	1.6	2.3	2.3
Ever had prostate specific antigen (PSA) test	2.9	3.3	9.9	-0.4	1.1	1.3	0.8	3.1	2.5
Respiratory disease	2.8	6.3	13.4	-1.4	-2.7	-1.4	-1.1	-3.7	-3.5
Medication: Metformin	2.8	3.9	7.8	0.9	2.1	1.6	2.8	1.9	2.1
Tinnitus: Yes, but not now, but have in the past	2.8	3.0	6.1	0.8	1.8	0.9	2.5	1.7	2.1
Peak expiratory flow (PEF)	2.7	6.2	12.2	-1.4	-2.8	-1.1	-3.5	-2.9	-2.3
Medication: Omeprazole	2.7	3.3	6.7	1.1	2.5	0.3	1.0	2.6	2.1
Medication: Levothyroxine sodium	2.6	4.5	7.0	-2.3	-2.1	-1.4	-2.3	-2.6	-1.8
Frequency of tenseness / restlessness in last 2 weeks	2.6	4.0	9.7	-1.2	3.1	1.1	2.4	1.1	2.2
Illnesses of siblings	2.6	3.7	6.6	-0.3	-2.5	-0.8	-2.6	-1.8	-2.3
Pulse wave peak to peak time	2.6	3.1	5.9	-2.3	-0.8	-1.6	-1.7	-2.4	-1.1
Medication: Gliclazide	2.6	2.9	7.1	1.1	1.4	0.7	2.7	1.9	1.8
Hand grip strength (left)	2.5	6.5	16.6	0.2	-2.9	-2.8	-4.1	-1.9	-1.7
Angina	2.5	3.3	12.5	-3.5	-1.3	-0.3	1.1	-1.6	-1.3
Pack years of smoking	2.5	3.7	7.7	0.7	2.8	1.4	1.9	1.7	2.3
Impedance of leg (right)	2.4	11.6	16.3	-2.9	-3.9	-3.4	-2.3	-4.0	-3.5
Alcohol usually taken with meals	2.4	3.8	6.2	0.4	-2.0	-1.7	-2.2	-2.5	-2.2
Pulse rate	2.4	4.0	5.5	2.0	2.3	1.7	1.5	2.3	2.0
Birth weight of first child	2.4	4.4	9.4	2.3	1.5	0.6	2.0	3.1	2.2
Angina (self-reported)	2.4	3.2	11.9	-3.4	-1.4	-0.2	1.1	-1.6	-1.3
Friendships satisfaction	2.4	3.0	7.6	0.0	1.6	1.0	1.7	2.8	2.1
Neuroticism (2016)	2.3	3.3	5.2	0.9	2.3	1.7	1.8	2.1	1.8
Mouth/teeth dental problems	2.3	3.5	7.7	-1.2	-1.5	-2.0	-2.8	-2.1	-1.2
Standing height	2.3	23.0	54.0	1.6	-6.1	-4.4	-7.3	-3.8	-3.2
Medication: Ibuprofen	2.3	2.8	4.6	2.1	1.9	2.1	1.1	1.4	0.8
Mean time to correctly identify matches	2.3	4.4	11.4	-2.2	-2.6	-3.4	-0.4	-0.7	-1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.3	2.6	7.5	0.4	1.2	2.7	1.6	1.5	1.5
Ever taken oral contraceptive pill	2.3	2.6	4.8	2.2	1.2	1.7	2.1	1.2	0.4
Worry (Nagel 2018)	2.2	4.7	9.4	0.0	2.4	1.2	3.1	2.8	2.0
Height	2.2	43.1	92.5	0.8	-8.2	-5.9	-9.6	-6.5	-4.6
Pack years adult smoking proportion	2.2	3.4	7.6	0.6	2.8	1.3	1.8	1.6	2.3
Impedance of leg (left)	2.2	10.8	15.3	-3.0	-3.7	-3.4	-2.3	-3.9	-3.2
Frequency of tiredness / lethargy in last 2 weeks	2.2	3.6	13.0	-0.3	3.6	0.4	1.5	1.2	2.1
Pain all over the body in last month	2.1	2.2	5.6	-0.9	-1.1	-2.4	0.2	-1.6	-1.7
Pulse wave Arterial Stiffness index	2.1	2.5	6.2	2.5	0.4	1.3	1.2	2.1	0.9
High blood pressure (siblings)	2.1	3.1	7.3	0.6	1.7	0.5	2.7	2.2	1.7
Ovarian Cancer	2.0	2.6	4.0	0.9	1.7	1.9	2.0	1.2	1.7
Diabetes (mother)	2.0	2.5	5.7	-0.0	1.6	-0.5	1.2	2.3	2.4
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.7	4.2	0.7	2.1	1.8	2.0	1.4	1.4
Health satisfaction	2.0	2.6	5.0	-0.0	2.2	1.6	1.3	1.3	2.2
Neck or shoulder pain in last month	2.0	2.9	7.2	-0.7	2.7	-0.2	2.3	1.1	1.8
Had major operations	2.0	2.3	6.6	0.3	-1.2	0.2	-1.7	-2.6	-1.7
Neuroticism (Nagel 2018)	1.9	4.6	7.3	0.8	2.7	1.6	2.5	2.5	2.1
Schizophrenia (2014)	1.9	4.2	11.9	0.2	2.1	3.5	0.7	1.6	2.3
Systolic Blood Pressure	1.9	9.7	17.6	-2.7	-3.1	-1.8	-3.3	-4.2	-3.0
Systolic blood pressure, automated reading	1.9	5.4	7.0	-1.6	-2.5	-2.6	-2.4	-2.6	-2.0
Qualifications: CSEs or equivalent	1.9	2.5	7.8	-2.8	-0.8	1.3	-0.0	-1.3	-1.7
Worrier / anxious feelings	1.9	3.6	6.6	-0.3	2.6	2.0	2.0	1.7	2.1
Medication: Lansoprazole	1.9	2.1	3.9	-2.0	-0.9	1.1	1.6	-1.5	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	6.0	9.6	-1.7	-2.6	-1.2	-3.1	-3.1	-2.4
Gout (self-reported)	1.9	2.6	7.3	2.2	1.5	2.7	0.8	0.5	0.9
Family relationship satisfaction	1.9	2.3	5.0	-0.2	1.3	1.5	0.9	1.9	2.2
Forced expiratory volume in 1-second (FEV1), predicted	1.9	3.9	7.4	-0.6	-2.4	-0.5	-2.7	-2.5	-2.0
Severe depression (siblings)	1.8	2.1	4.3	1.8	2.1	0.4	0.6	1.4	1.6
Happiness	1.8	2.2	5.0	-0.0	1.8	1.3	0.8	2.2	1.8
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.3	3.3	1.7	1.8	1.8	1.5	1.3	0.8
Medication for pain relief, constipation, heartburn	1.8	3.1	6.7	-1.1	-1.8	-2.6	-2.1	-1.2	-1.2
Overall health rating	1.8	4.0	8.8	-0.9	3.0	1.1	3.0	0.7	1.9
Asthma (self-reported)	1.8	3.5	8.8	-1.0	-2.0	-0.0	-0.4	-3.0	-2.6
Miserableness	1.8	3.0	6.9	-0.0	2.6	2.1	0.5	1.8	1.8
Pain type(s) experienced in last month: Hip pain	1.8	2.2	4.9	0.3	1.5	0.3	1.8	2.2	1.7
Unable to work because of sickness or disability	1.8	2.3	3.1	-1.8	1.6	0.7	1.6	1.4	1.8
Age at First Birth	1.7	2.5	9.2	-3.0	-1.3	0.1	-1.4	-1.1	-1.1
Qualifications: None of the above	1.7	3.7	10.2	-0.1	2.1	0.3	3.2	1.7	2.1
Time employed in main current job	1.7	2.0	4.8	2.0	0.9	-1.1	0.7	2.2	0.4
Serious illness, injury or assault of a close relative in last 2 years	1.7	1.9	3.2	1.6	1.5	-0.4	0.4	1.8	1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.5	4.7	-0.5	2.0	-0.4	1.9	2.2	1.6
Medication: Ventolin 100micrograms inhaler	1.7	2.2	5.7	-2.4	-1.3	0.5	0.2	-1.5	-1.9
Loneliness, isolation	1.7	2.4	5.3	0.7	2.3	0.8	1.2	1.6	1.9
Ever had bowel cancer screening	1.7	2.0	3.1	0.4	1.7	1.0	1.7	1.5	1.8
Medication: Ramipril	1.6	2.1	4.7	0.4	1.7	-0.4	2.2	1.2	1.7
Average weekly red wine intake	1.6	2.4	5.2	0.9	-0.9	0.7	-2.1	-2.3	-1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	4.6	0.4	-1.1	-0.4	-1.5	-2.1	-1.8
Frequency of depressed mood in last 2 weeks	1.5	2.2	2.9	0.7	1.7	1.5	1.3	1.6	1.7
Relative age of first facial hair	1.5	3.0	5.6	-0.3	-1.8	0.1	-2.1	-2.4	-2.2
Headache pain in last month	1.5	2.6	7.8	0.4	1.9	2.8	2.0	-0.2	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	2.0	3.9	-2.0	1.9	-0.1	1.7	0.9	1.0
Back pain experienced in last month	1.5	2.2	3.8	0.7	1.9	1.6	1.4	1.7	1.2
Supplements: Calcium	1.5	1.6	5.3	-0.3	-0.7	-0.2	-1.2	-2.3	-1.6
Depressed Affect (Nagel 2018)	1.4	3.0	7.1	0.5	2.7	1.0	1.6	2.0	1.8
Diabetes (father)	1.4	1.7	5.1	-2.2	-0.1	-1.7	-0.8	-1.1	-0.6
Chronic bronchitis/emphysema (father)	1.4	1.7	4.1	0.5	1.6	0.5	0.4	2.0	1.6
Neuroticism score	1.4	2.9	6.1	-0.6	2.5	1.8	2.0	1.2	1.4
Forced vital capacity (FVC), Best measure	1.4	5.2	9.3	-1.5	-2.5	-1.6	-3.0	-2.7	-1.9
Medication: Atorvastatin	1.4	1.8	3.9	0.1	1.4	0.7	1.9	2.0	0.7
Impedance of whole body	1.4	7.1	11.1	-2.8	-3.0	-2.1	-1.7	-3.3	-2.8
HDL Cholesterol	1.3	2.1	5.8	-0.5	-1.3	-1.4	-2.4	-1.4	-0.8
Neuroticism	1.3	3.0	6.1	0.2	2.5	0.9	2.3	1.9	1.6
Ever had hysterectomy (womb removed)	1.3	1.5	2.2	-1.5	-1.5	-0.8	0.3	-1.4	-1.3
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	2.8	-1.6	-1.1	-1.7	-1.1	-0.9	-0.6
Forced expiratory volume in 1-second (FEV1)	1.3	4.3	7.7	-1.4	-2.2	-1.0	-2.8	-2.5	-2.1
Asthma	1.3	2.5	6.7	-1.0	-1.7	0.2	-0.2	-2.6	-2.1
Qualifications: College or University degree	1.3	3.9	7.4	1.1	-2.3	-0.8	-2.7	-2.2	-2.1
Handedness (chirality/laterality): Left-handed	1.3	1.6	3.6	0.9	-1.0	-0.9	-1.9	-0.7	-1.6
Breast cancer (self-reported)	1.3	1.5	6.1	-1.4	-0.7	-2.5	-0.4	-0.3	-0.5
Hearing aid user	1.3	1.5	2.8	-0.9	-1.3	-1.7	1.6	-0.7	-0.9
Fasting Glucose	1.2	1.5	4.0	0.6	0.2	0.8	-0.2	1.9	2.0
Ever used hormone-replacement therapy (HRT)	1.2	1.5	2.5	1.5	0.9	0.7	1.1	1.6	1.3
Stomach or abdominal pain in last month	1.2	1.4	3.3	-0.7	1.8	1.2	1.4	-0.5	1.1
Alcohol intake frequency.	1.2	2.8	5.4	0.1	2.2	1.0	2.3	1.4	1.8
Major Depression (MDD)	1.1	1.3	2.8	0.1	1.7	0.5	1.3	1.0	1.4
Blood Eosinophil Count	1.1	8.7	21.9	-1.6	-3.0	-0.7	-2.2	-4.7	-3.7
Smoking Status	1.1	2.7	4.4	1.2	2.1	1.5	1.8	1.7	1.5
Other serious medical condition/disability diagnosed by doctor	1.1	1.5	4.7	-1.3	-0.4	-0.5	-0.9	-2.2	-1.0
Hearing difficulty/problems with background noise	1.1	1.7	3.3	-1.2	1.8	0.7	1.6	1.0	1.2
Diabetes (self-reported)	1.1	1.7	3.7	0.0	1.7	1.1	1.9	0.8	1.3
Exposure to tobacco smoke outside home	1.1	1.5	6.9	-2.6	-0.4	-0.1	1.0	-0.8	-0.5
Medication: Allopurinol	1.1	1.5	4.7	2.2	1.0	1.6	0.0	0.3	0.9
Commuting to job workplace: Public transport	1.1	1.4	4.1	-0.5	-2.0	-1.3	-0.9	-0.4	-1.1
Medication: Blood pressure	1.1	2.1	3.1	1.6	1.0	1.6	1.8	0.7	1.6
Number of operations (self-reported)	1.1	1.6	3.4	-0.4	-1.0	-0.8	-1.2	-1.7	-1.8
Blood Red Count	1.0	9.5	18.3	-4.3	-1.9	-3.0	-2.9	-3.5	-2.4
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.2	7.6	1.7	1.6	-0.3	2.8	0.4	-0.2
Mouth/teeth dental problems: Dentures	1.0	1.7	3.0	1.1	1.3	0.2	1.7	1.6	1.4
Length of working week for main job	1.0	1.1	2.2	-1.5	-0.9	-1.1	-1.5	0.4	-0.1
Breastfed as a baby	1.0	1.2	2.2	-1.1	-1.5	-0.2	-1.0	-1.1	-1.3
Wheeze or whistling in the chest in last year	1.0	1.9	4.0	-2.0	0.9	1.0	0.7	-2.0	-0.9
Number of full sisters	1.0	1.2	3.2	-0.5	-1.8	-1.2	-0.3	-0.5	-1.5
Average weekly beer plus cider intake	1.0	1.5	3.0	-1.7	-1.1	-0.3	-0.9	-1.3	-1.5
Risk taking	1.0	1.4	4.0	-0.1	1.0	0.5	1.4	2.0	1.2
Basal cell carcinoma (self-reported)	1.0	1.2	3.6	-1.2	-0.3	-1.2	0.5	1.9	0.7
Bipolar Disorder or Schizophrenia	0.9	2.2	7.5	-0.3	1.4	2.7	0.7	0.6	1.6
Schizophrenia (2018)	0.9	1.8	7.8	0.1	1.0	2.8	0.5	0.6	1.2
Alzheimer’s Disease (in father)	0.9	1.0	2.7	1.2	0.1	1.0	1.6	0.8	0.2
Triglycerides	0.9	1.4	5.2	0.6	1.3	0.7	2.3	0.6	0.6
Fed-up feelings	0.9	1.7	3.6	-0.7	1.9	1.5	1.4	0.7	1.0
Alcohol intake versus 10 years previously	0.9	1.3	2.5	1.6	0.9	1.6	0.3	1.3	0.5
Number of live births	0.9	1.3	4.4	0.1	-0.9	-2.1	0.5	1.6	0.0
Tense / ‘highly strung’	0.9	1.4	3.0	0.2	1.7	0.2	1.7	1.4	1.0
Medication: Seretide 50 evohaler	0.9	1.0	2.0	0.5	0.8	1.4	1.4	0.2	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.8	-0.2	1.1	0.3	1.3	1.7	1.0
Comparative height size at age 10	0.9	5.1	13.8	0.5	-2.8	-2.7	-3.7	-1.1	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.5	-0.5	-0.3	-0.9	-1.1	-1.6	-1.2
Qualifications: nursing, teaching	0.9	1.4	3.8	-0.9	-0.7	-1.4	-1.9	-0.9	-0.8
Tinnitus: Yes, now most or all of the time	0.9	1.0	2.4	-1.0	-0.9	-1.6	-0.3	-1.0	-0.9
Alcohol drinker status: Previous	0.9	1.0	3.1	-0.7	0.8	-1.0	1.8	0.3	0.9
Lung FEV1/FVC ratio	0.8	4.1	8.9	-0.1	-2.3	0.9	-1.5	-3.0	-2.8
Hair Pigment	0.8	22.8	32.3	-2.6	-5.5	-3.8	-5.2	-5.0	-5.7
Relative age voice broke	0.8	1.2	2.3	1.5	0.6	1.2	1.1	0.7	1.1
Forced vital capacity (FVC)	0.8	3.2	7.7	-1.1	-1.8	-1.3	-2.8	-1.8	-1.5
Medication: Simvastatin	0.8	1.1	5.5	-2.4	-0.4	0.2	-0.5	-0.8	-0.0
Impedance of arm (right)	0.8	3.6	8.1	-1.8	-1.9	-0.9	-1.0	-2.9	-2.1
Trunk fat-free mass	0.8	4.5	14.8	2.0	-1.9	-2.1	-3.9	-0.4	-0.0
Impedance of arm (left)	0.8	3.9	6.8	-1.8	-2.3	-1.1	-1.1	-2.6	-2.4
Trunk predicted mass	0.8	4.7	15.4	2.0	-2.0	-2.1	-3.9	-0.4	-0.1
Mood swings	0.8	1.4	3.0	-0.4	1.7	0.8	0.7	1.6	1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	1.7	-0.3	1.2	1.3	1.2	0.4	0.7
Average weekly champagne plus white wine intake	0.8	1.0	4.1	2.0	0.2	-0.9	1.0	0.3	-0.4
High cholesterol (Self-reported)	0.8	1.4	5.0	-0.2	1.0	2.2	0.2	1.0	1.2
Bipolar Disorder (2011)	0.7	0.7	1.4	-0.5	0.6	1.0	0.9	0.6	1.2
Lupus	0.7	1.1	2.5	0.8	-0.8	0.3	-0.9	-1.6	-1.2
Type 2 Diabetes (T2D) (2018)	0.7	1.3	2.7	0.1	1.5	0.6	1.6	0.3	1.4
Average weekly fortified wine intake	0.7	0.8	3.1	0.2	-0.4	-0.9	-0.9	-1.7	-0.1
Hair/balding pattern: Pattern 3	0.7	1.0	3.1	-0.4	1.8	1.5	0.3	-0.0	0.8
Noisy workplace	0.7	0.8	1.8	-1.3	-0.3	-1.2	-0.5	-1.1	-0.4
Prospective memory result	0.7	0.8	1.7	-1.1	-1.0	-1.3	0.5	0.2	-0.8
Number of full brothers	0.7	0.9	3.0	-0.9	0.9	-0.0	1.0	0.1	1.7
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.8	-1.2	-0.4	0.8	-0.3	-1.4	-0.7
Emphysema/chronic bronchitis	0.7	0.8	3.2	0.3	0.5	-0.9	1.8	0.7	0.6
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	2.4	0.3	-1.1	1.5	-0.9	-0.4	-0.8
Diabetes diagnosed by doctor	0.7	1.2	2.6	-0.2	1.6	0.5	1.3	0.4	1.5
Illnesses of father: None of the above (group 1)	0.7	0.9	4.5	2.1	-0.2	0.5	-0.1	0.4	0.3
Mother’s age at death	0.7	0.9	4.1	2.0	-0.1	0.9	-0.5	0.2	0.1
Irritability	0.7	1.1	2.5	0.1	1.4	1.6	1.4	0.4	0.5
Fractured/broken bones in last 5 years	0.7	0.9	2.2	-1.1	1.5	1.2	0.6	0.1	0.6
Alzheimer’s Disease (including proxy)	0.6	0.8	2.2	1.2	0.6	0.7	1.5	0.4	0.2
Chronotype (morning person)	0.6	1.4	2.8	-1.1	-1.5	-1.7	-0.9	-0.3	-1.1
Townsend deprivation index at recruitment	0.6	0.9	1.5	-0.8	-0.8	-1.0	-0.6	-1.2	-1.2
Current tobacco smoking	0.6	1.0	1.6	0.8	1.3	1.0	0.8	1.1	0.8
Supplements: Glucosamine	0.6	0.8	3.8	1.9	1.0	0.0	-0.0	0.4	0.3
Sitting height	0.6	4.0	11.0	3.3	-1.2	-1.0	-3.2	-0.6	0.6
Nervous feelings	0.6	1.1	3.3	0.3	1.1	-0.5	1.8	1.0	0.8
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	2.4	-1.5	-0.2	1.1	0.0	-0.9	-0.4
Hip circumference	0.6	2.7	8.6	0.2	-1.2	-0.9	-2.9	-2.2	-0.7
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.9	0.6	0.5	1.7	0.9	0.4	0.3
Blood clot in the leg (DVT)	0.6	0.8	2.1	-1.4	-0.6	0.9	-0.3	-0.9	-0.9
Medication: Paracetamol	0.6	1.0	3.0	-0.0	0.9	1.1	1.7	0.9	0.7
Arm predicted mass (right)	0.6	2.8	9.9	1.8	-1.4	-1.3	-3.1	-0.2	0.1
Illnesses of siblings: Diabetes	0.6	0.7	1.6	-0.2	0.9	-0.4	1.3	1.0	0.8
Smoking status: Previous	0.6	0.8	2.5	0.7	0.5	0.3	0.6	1.6	1.1
Long-standing illness, disability or infirmity	0.6	0.9	2.9	-1.7	0.5	0.7	0.4	-1.2	-0.1
Medication: Aspirin	0.6	0.8	2.4	-0.0	0.6	1.4	1.5	0.4	0.4
Smoking status: Current	0.6	1.0	1.8	0.7	1.3	1.2	1.1	0.7	0.6
Wears glasses or contact lenses	0.6	0.7	1.1	0.3	1.0	-1.0	0.4	1.1	0.6
Medication: Lisinopril	0.6	0.8	2.6	1.0	0.4	1.6	0.2	0.6	0.8
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.7	-1.2	-0.4	1.3	-0.0	-0.8	-0.7
Arm predicted mass (left)	0.6	3.1	11.1	1.2	-1.6	-1.8	-3.3	-0.4	-0.2
Alzheimer’s Disease (in mother)	0.5	0.6	1.5	1.0	1.2	0.6	0.8	-0.3	0.4
Ulcerative Colitis (UC)	0.5	0.9	2.3	-0.3	-1.2	-1.0	-1.5	0.5	-0.7
HbA1C	0.5	0.5	1.4	0.6	0.8	1.2	0.9	-0.1	0.3
LDL Cholesterol	0.5	0.8	2.0	1.4	0.0	0.6	1.1	-0.1	-1.0
Primary Biliary Cirrhosis	0.5	0.7	2.7	-1.7	-0.6	0.6	-0.3	-0.6	-0.7
Type 2 Diabetes (T2D) (2012)	0.5	0.6	2.0	-0.7	0.3	-0.0	-1.4	-0.9	-0.0
Sensitivity / hurt feelings	0.5	0.8	2.8	0.9	0.5	1.7	-0.4	-0.9	-0.2
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.8	-1.3	-0.3	-0.9	0.5	-0.5	-0.4
Multivitamins +/- minerals	0.5	0.7	2.4	0.1	0.4	0.5	1.0	-1.5	-0.3
Medication: Atenolol	0.5	0.7	3.0	-0.0	0.6	1.7	0.7	-0.4	0.1
Past tobacco smoking	0.5	0.9	2.7	-0.6	-0.7	-0.4	-0.8	-1.6	-1.0
Hair/balding pattern: Pattern 2	0.5	0.6	1.1	0.1	0.5	-0.8	1.0	1.0	1.0
Had other major operations	0.5	0.6	1.2	-0.7	-1.1	-0.5	-1.0	-0.1	-0.6
Falls in the last year	0.5	0.7	3.6	-1.9	-0.1	-0.2	-0.2	0.8	-0.1
Exposure to tobacco smoke at home	0.5	0.6	1.0	-1.0	0.7	1.0	-0.4	0.5	0.7
Pulse wave reflection index	0.5	0.6	3.1	1.7	-0.0	-0.4	-0.0	-0.5	-0.6
Arm fat-free mass (right)	0.5	2.8	10.1	1.4	-1.4	-1.5	-3.2	-0.2	0.1
Heart disease (mother)	0.5	0.6	1.4	-1.0	0.5	-0.6	-0.6	0.8	1.2
Age at last live birth	0.5	0.8	2.2	-0.3	1.5	-1.3	0.4	0.1	0.7
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.6	1.0	0.8	0.6	1.3	-0.4	0.4
Medication: Aspirin	0.5	0.7	2.1	-0.2	0.6	1.1	1.4	0.4	0.5
Whole body fat-free mass	0.5	3.0	10.6	2.0	-1.2	-1.2	-3.2	-0.2	0.3
Osteoporosis (self-reported)	0.5	0.6	2.2	-0.3	-0.1	1.5	-0.7	-0.8	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.5	-1.2	0.0	-1.6	0.5	-1.3	-0.4
Whole body water mass	0.5	3.0	10.5	2.0	-1.3	-1.3	-3.2	-0.2	0.2
Number of self-reported non-cancer illnesses	0.5	0.9	2.9	0.5	0.5	1.7	0.7	-1.2	-0.3
Financial situation satisfaction	0.5	0.6	2.8	-1.7	-0.1	-0.6	-0.6	0.2	0.2
Basal metabolic rate	0.5	2.8	10.2	1.7	-1.2	-1.3	-3.2	-0.5	0.1
Arm fat-free mass (left)	0.5	2.5	8.7	1.4	-1.4	-1.5	-3.0	-0.3	0.0
Age started oral contraceptive pill	0.5	0.6	2.0	0.3	-0.6	-0.6	-0.4	-1.4	-0.9
Ever depressed for a whole week	0.5	0.7	1.7	-1.3	0.8	0.7	0.9	-0.5	-0.2
Myopia	0.5	0.8	1.5	-0.2	-0.7	-0.7	-0.7	-1.2	-1.2
Body Mass Index (BMI) (2010)	0.4	0.5	1.7	-0.5	0.3	-1.3	0.6	-0.5	0.4
Crohns Disease (2012)	0.4	0.7	1.6	-0.7	-1.1	-0.5	-0.7	0.0	-1.3
Mean Putamen Volume	0.4	0.4	1.7	1.3	0.3	0.5	-0.2	0.2	0.7
Cardiovascular Disease	0.4	1.3	2.9	1.2	0.8	1.7	1.1	0.0	1.3
Lung FVC	0.4	1.9	4.8	-2.2	1.8	1.2	1.0	-0.7	0.6
Supplements: Zinc	0.4	0.5	1.7	-1.3	0.7	-0.4	-0.5	-0.4	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.4	0.2	0.9	-1.0	1.5	-0.6	-0.8
High blood pressure	0.4	1.2	3.2	1.8	0.4	1.3	0.9	-0.5	0.9
Trunk fat mass	0.4	1.9	4.2	-0.8	-0.8	-1.6	-1.8	-2.0	-0.7
Number of incorrect matches in round	0.4	0.6	1.5	-0.9	-1.2	-0.3	0.0	-0.2	-1.1
Financial difficulties in last 2 years	0.4	0.6	1.7	-0.7	-0.2	-1.3	0.9	-0.4	-0.5
Heart attack	0.4	0.5	2.2	-0.2	1.0	-0.3	1.5	-0.0	0.2
Weight	0.4	2.1	6.7	0.6	-1.0	-1.5	-2.6	-1.5	-0.4
Medication: Cholesterol lowering	0.4	0.6	3.0	-1.7	-0.3	0.2	-0.2	-0.2	-0.8
Glaucoma (self-reported)	0.4	0.5	1.3	1.1	0.5	0.2	0.6	0.9	0.3
Worry too long after embarrassment	0.4	0.6	1.5	-0.5	1.0	1.2	-0.1	-1.0	-0.2
Age at first live birth	0.4	0.8	1.7	-0.1	0.1	-1.3	-0.7	-1.3	-0.9
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.6	-0.6	-0.4	-0.7	1.2	0.2	-0.4
Hypertension (Self-reported)	0.4	1.0	2.5	1.6	0.4	1.0	1.3	-0.4	0.9
Eye problems/disorders: Cataract	0.4	0.4	1.1	0.5	-1.1	-0.3	-1.0	0.4	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.2	0.8	1.0	1.1	0.6	0.8	0.5
Medication for cholesterol	0.4	0.6	1.6	-0.8	-0.9	-0.1	-0.8	0.2	-1.2
Illnesses of father: High blood pressure	0.4	0.5	1.0	0.7	0.7	0.4	1.0	0.4	0.6
Commuting to job workplace: Cycle	0.4	0.5	1.2	1.1	-0.3	0.2	-0.8	1.0	0.2
Heart attack/myocardial infarction (self-reported)	0.4	0.5	2.0	-0.0	0.9	-0.4	1.4	0.0	0.2
Bipolar Disorder (2018)	0.3	0.5	1.1	0.3	1.0	0.9	0.3	0.2	1.0
Intelligence (Savage-Jansen 2018)	0.3	0.8	2.2	0.8	-0.8	-0.9	-1.5	-0.2	-0.6
Schizophrenia vs Biploar Disorder	0.3	0.4	1.1	-1.0	0.1	0.6	1.0	0.4	-0.1
Crohns Disease (2017)	0.3	0.7	2.3	-0.1	0.9	0.1	0.7	1.5	0.6
Ulcerative Colitis	0.3	0.5	1.2	-1.1	-0.6	-0.7	-0.8	0.3	-0.5
Heel T-Score	0.3	2.7	8.4	-0.0	0.9	-2.0	2.9	1.5	-0.7
Waist Hip Ratio (WHR)	0.3	1.1	5.3	0.4	-0.5	-2.3	0.4	-0.6	-0.7
Hearing difficulty/problems: Yes	0.3	0.5	1.5	-0.9	0.6	0.2	1.2	-0.1	-0.4
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.9	-0.7	0.3	0.3	0.5	-0.2	1.0
Leg fat-free mass (left)	0.3	1.5	4.7	2.0	-0.3	0.1	-2.2	0.1	0.7
Trunk fat percentage	0.3	1.3	3.9	-1.5	-0.2	-0.9	-0.6	-2.0	-0.8
Taking other prescription medications	0.3	0.4	1.0	-0.5	1.0	0.8	0.6	-0.2	0.2
Serious illness, injury or assault to yourself	0.3	0.3	0.7	-0.8	0.5	-0.6	-0.1	-0.8	-0.1
Leg predicted mass (left)	0.3	1.5	4.7	2.0	-0.3	0.0	-2.2	0.1	0.7
Waist circumference	0.3	1.0	2.7	0.0	-0.6	-1.6	-1.0	-1.4	-0.3
Had menopause	0.3	0.4	1.3	0.1	-0.3	-0.1	0.7	1.1	0.5
Fluid intelligence score	0.3	0.7	2.9	1.7	0.5	0.1	-0.9	0.2	0.5
Medication: Amlodipine	0.3	0.4	1.4	-0.0	-0.7	-0.5	-0.1	-1.2	-0.4
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.9	0.9	0.4	-0.6	-0.7	0.1	0.7
Leg fat percentage (right)	0.3	1.2	2.5	-1.6	0.0	-1.4	-0.3	-1.5	-0.5
Chest pain or discomfort	0.3	0.5	1.8	-1.4	0.8	-0.1	-0.2	-0.4	0.1
Illnesses of father: Heart disease	0.3	0.4	1.1	-1.0	0.5	0.7	-0.9	-0.1	-0.0
Leg fat-free mass (right)	0.3	1.6	4.5	2.0	-0.1	0.2	-2.1	0.4	0.9
Commuting to job workplace: Walk	0.3	0.4	1.6	-1.2	-0.3	-0.7	-0.3	0.0	-0.1
Leg predicted mass (right)	0.3	1.6	4.4	2.0	-0.1	0.2	-2.1	0.4	0.9
Guilty feelings	0.3	0.4	2.2	-0.3	-0.2	1.5	-0.2	-0.1	-0.5
Medication: Paracetamol	0.3	0.5	2.4	0.1	0.2	0.6	1.5	0.6	0.2
Leg fat percentage (left)	0.3	1.0	2.4	-1.5	0.2	-1.2	-0.3	-1.3	-0.2
Leg fat mass (left)	0.3	1.0	2.0	-0.6	-0.2	-1.4	-1.3	-1.4	0.0
Irritable Bowel Disease (IBD)	0.2	0.5	1.3	-0.6	-0.5	-0.7	-0.5	1.1	-0.2
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.4	1.2	0.3	-0.6	-0.5	0.8	0.4
Coronary Artery Disease (CAD)	0.2	0.2	0.5	0.7	0.7	0.6	0.2	0.1	0.3
BMI	0.2	1.1	2.4	0.0	1.6	-0.0	0.7	1.0	1.6
Number of treatments/medications taken	0.2	0.3	1.7	0.1	0.3	0.4	1.3	-0.1	-0.1
Vitamin and mineral supplements	0.2	0.3	0.7	-0.4	0.0	-0.4	-0.8	0.9	0.6
Body mass index (BMI)	0.2	0.9	3.4	-0.1	1.8	0.6	0.7	0.3	1.1
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.6	1.3	0.2	0.1	-0.5	0.3	0.8
Depression (self-reported)	0.2	0.3	0.9	-0.9	-0.0	0.5	0.3	-0.0	-0.5
Illnesses of mother	0.2	0.2	0.7	-0.2	-0.8	0.4	0.1	-0.3	-0.6
Loud music exposure frequency	0.2	0.3	0.8	0.1	0.8	0.9	0.3	0.2	0.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.6	-0.8	-0.8	0.5	-0.8	-0.2	-0.4
Body fat percentage	0.2	0.9	2.6	-1.4	0.2	-0.9	-0.2	-1.6	-0.4
Number of children fathered	0.2	0.2	0.8	0.0	-0.7	0.4	0.2	-0.2	-0.9
Medication: Blood pressure	0.2	0.4	1.2	0.1	-0.4	1.1	1.0	-0.2	-0.2
Whole body fat mass	0.2	1.0	2.3	-0.3	-0.2	-1.3	-1.4	-1.5	-0.2
Leg fat mass (right)	0.2	0.9	2.1	-0.6	-0.0	-1.4	-1.2	-1.4	0.0
Alcohol drinker status: Never	0.2	0.3	0.6	-0.6	0.4	0.6	0.3	-0.2	0.8
Ever smoked	0.2	0.3	0.7	-0.3	-0.5	-0.8	0.0	0.8	-0.2
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.3	-0.8	-0.2	-1.1	-0.7	0.9	-0.6
Cholesterol lowering medication	0.2	0.2	0.8	-0.3	0.1	0.3	0.5	0.2	0.9
Average weekly spirits intake	0.1	0.2	0.5	0.2	-0.1	0.4	0.5	-0.7	0.3
Medication for hormone replacement therapy	0.1	0.1	0.2	0.3	0.1	-0.4	-0.3	-0.5	-0.4
Age when periods started (menarche)	0.1	0.2	0.7	0.5	0.2	0.3	0.8	-0.0	0.1
High blood pressure (mother)	0.1	0.2	0.6	-0.8	0.3	-0.1	0.4	0.0	0.1
Arm fat percentage (right)	0.1	0.5	1.1	-0.9	1.0	-0.2	0.5	-0.8	0.3
Father’s age at death	0.1	0.2	0.7	0.2	0.8	-0.5	0.1	-0.3	0.2
Arm fat mass (right)	0.1	0.3	0.6	-0.2	0.3	-0.7	-0.7	-0.8	0.1
Hair/balding pattern: Pattern 4	0.1	0.3	0.6	0.5	0.5	-0.5	0.8	-0.3	-0.3
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.6	0.4	0.5	-0.0	-0.1	0.6	0.8
Comparative body size at age 10	0.1	0.3	0.8	-0.4	0.4	-0.2	-0.5	0.9	0.7
Arm fat percentage (left)	0.1	0.4	1.0	-1.0	0.9	-0.2	0.3	-0.8	0.1
Mineral and other dietary supplements	0.1	0.1	0.3	-0.2	0.1	0.1	0.2	0.5	0.5
Arm fat mass (left)	0.1	0.4	0.9	-0.2	0.3	-0.8	-1.0	-0.9	0.1
Eye problems/disorders: Glaucoma	0.1	0.1	0.3	0.6	-0.1	0.0	0.2	-0.1	-0.3
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.2	-0.3	0.3	-0.3	0.3	-0.4	0.4
Diastolic blood pressure, automated reading	0.1	0.4	1.4	1.2	-0.2	-0.5	-0.1	-0.8	-0.1
Heart disease (siblings)	0.1	0.2	0.4	-0.0	-0.3	0.4	0.3	0.6	0.4
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Tanning	0.0	0.4	2.0	-1.4	0.2	0.6	0.2	-0.2	0.3
Eye problems/disorders: None of the above	0.0	0.1	0.1	0.3	0.3	0.4	0.0	-0.1	-0.2

Hub : Genes

PHF19

Models

Trait associations