Hub : Genes

DENND1A

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.063 0.0260 0.00057 0.015 0.036 0.012 0.031 0.014 5.2e-03 2.6e-05 1.1e-02 1.1e-04 7.0e-03
2 GTEx Adipose Subcutaneous 0.102 0.0460 0.00870 0.002 NA 0.000 NA -0.001 2.0e-01 NA 3.3e-01 NA 3.6e-01
3 YFS Blood 0.148 0.0272 0.00000 0.054 0.087 0.089 0.094 0.095 2.9e-17 7.5e-27 1.4e-27 5.1e-29 1.7e-29
4 TCGA Soft Tissue Sarcoma 0.070 0.0370 0.00530 0.062 0.044 0.048 NA 0.051 1.5e-04 1.2e-03 7.7e-04 NA 5.7e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.2 0.3 0.7 -0.1 0.8 0.6 -0.1
Bipolar Disorder or Schizophrenia 0.3 0.8 2.0 -0.7 0.7 -0.6 -1.4
Depressed Affect (Nagel 2018) 0.5 1.1 2.8 0.6 1.7 -0.8 0.8
Depression (Nagel 2018) 1.8 2.7 3.7 1.9 1.9 0.1 1.8
Intelligence (Savage-Jansen 2018) 0.1 0.3 0.7 -0.8 0.1 -0.8 0.2
Neuroticism (Nagel 2018) 1.6 3.8 7.5 1.5 2.7 -1.6 1.7
Schizophrenia (2018) 0.6 1.3 3.0 -0.8 0.4 -1.2 -1.7
Schizophrenia vs Biploar Disorder 1.6 2.1 4.2 1.8 2.0 0.2 1.1
Worry (Nagel 2018) 5.5 11.6 19.8 4.4 3.4 -2.6 2.8
Alzheimer’s Disease (in mother) 0.7 0.8 1.7 -0.8 -0.5 -0.7 -1.3
Alzheimer’s Disease (in father) 1.1 1.2 2.7 1.3 1.6 -0.7 0.1
Alzheimer’s Disease (including proxy) 0.3 0.4 1.0 0.4 0.3 -1.0 -0.4
Crohns Disease (2017) 0.8 1.7 5.7 0.5 0.6 -2.4 -0.7
Irritable Bowel Disease (IBD) 0.4 1.0 2.7 -0.5 0.0 -1.6 -1.1
Ulcerative Colitis (UC) 0.4 0.7 0.8 -0.6 -0.9 -0.8 -0.9
Major Depression (MDD) 1.6 1.9 3.3 0.9 1.8 -1.6 1.1
Reaction Time 0.3 0.5 1.4 0.7 0.3 -1.2 0.1
Verbal and Numeric Reasoning (VNR) 0.4 0.9 2.4 -1.5 -0.7 -0.8 -0.3
Breast Cancer 2.8 6.7 13.0 -3.6 -1.7 1.9 -2.7
Ovarian Cancer 1.3 1.7 3.5 1.1 1.0 -1.0 1.9
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 3.1 4.5 9.3 -2.5 -1.2 0.9 -3.1
Bipolar Disorder (2011) 0.7 0.7 1.8 -1.4 -0.6 -0.7 -0.5
Body Mass Index (BMI) (2010) 6.1 8.4 11.9 3.2 2.4 -2.4 3.4
Coronary Artery Disease (CAD) 0.2 0.3 0.9 0.9 -0.3 0.3 -0.1
Crohns Disease (2012) 0.6 0.9 1.8 1.0 0.7 -1.3 0.7
Mean Putamen Volume 1.3 1.5 4.9 -0.2 -0.7 2.2 0.8
Fasting Glucose 0.9 1.1 3.9 -0.7 0.0 2.0 -0.1
HbA1C 1.0 1.1 2.1 0.8 1.4 -1.0 0.8
HDL Cholesterol 0.2 0.3 0.7 -0.6 -0.8 0.4 -0.3
LDL Cholesterol 0.3 0.4 1.0 -0.3 1.0 -0.7 -0.3
Lupus 0.7 1.1 2.3 -1.3 -0.7 -0.3 -1.5
Neuroticism (2016) 2.9 4.2 5.1 1.9 2.3 -1.7 2.2
Primary Biliary Cirrhosis 1.5 2.1 5.4 1.2 0.4 -2.3 1.3
Rheumatoid Arthritis 0.3 0.4 0.9 -0.0 -0.1 0.9 -1.0
Schizophrenia (2014) 0.5 1.0 1.9 -1.3 0.6 -0.0 -1.4
Triglycerides 0.1 0.2 0.3 -0.1 0.0 -0.6 0.6
Type 2 Diabetes (T2D) (2012) 8.7 10.0 18.7 2.4 2.9 -4.3 2.7
Ulcerative Colitis 0.0 0.0 0.1 -0.3 0.1 0.2 0.1
Blood Eosinophil Count 0.2 1.8 5.7 -0.6 2.4 0.2 1.0
Blood Platelet Count 0.2 2.2 5.9 0.2 0.7 -1.6 2.4
Blood Red Count 0.1 0.6 2.2 1.5 -0.3 0.1 0.3
Blood White Count 1.6 12.2 31.0 1.8 2.0 -5.6 3.2
Heel T-Score 2.2 17.4 43.7 -6.6 -1.5 0.7 -4.8
BMI 1.8 10.3 17.3 1.2 2.4 -4.2 4.1
Height 0.7 14.1 38.1 6.2 0.5 -4.0 1.5
Waist Hip Ratio (WHR) 1.9 8.5 17.4 4.2 3.0 -0.0 2.7
Systolic Blood Pressure 0.2 1.1 2.4 0.5 -1.0 1.6 0.8
Smoking Status 0.7 1.8 3.0 1.7 0.5 -1.1 1.6
Allergy or Eczema 2.4 6.4 10.0 1.9 3.2 -1.5 3.1
Cardiovascular Disease 2.1 6.8 10.7 2.9 1.8 -2.3 3.3
Hypothyroidism (self reported) 0.3 0.6 1.4 -1.2 0.5 -0.6 -0.7
Respiratory disease 1.2 2.6 3.8 0.5 1.9 -1.8 1.8
Type 2 Diabetes (T2D) (2018) 2.0 3.7 8.3 -0.1 2.3 -2.9 1.0
Lung FEV1/FVC ratio 0.5 2.8 5.9 -2.4 -1.1 0.8 -1.8
Lung FVC 0.6 2.8 5.4 -1.7 -1.7 0.3 -2.3
Neuroticism 1.2 2.8 6.7 1.4 2.6 -1.3 1.0
Chronotype (morning person) 6.8 15.7 22.9 -4.8 -3.6 2.9 -4.3
Hair Pigment 0.9 24.6 28.0 -4.4 -5.2 5.0 -5.3
Tanning 0.5 6.5 13.2 -2.3 -2.4 3.6 -1.4
Hand grip strength (left) 0.4 1.0 1.7 -0.4 -1.3 0.8 -1.3
Number of treatments/medications taken 4.9 8.9 13.3 3.1 2.0 -2.9 3.6
Average weekly spirits intake 4.7 5.8 9.5 2.1 3.1 -1.8 2.5
Sensitivity / hurt feelings 0.9 1.6 2.3 1.3 1.5 -1.2 0.9
Frequency of depressed mood in last 2 weeks 2.5 3.5 6.6 2.0 2.6 -0.8 1.6
Hearing difficulty/problems: Yes 2.5 3.8 6.6 0.7 2.6 -2.5 1.4
Relative age of first facial hair 0.7 1.5 3.1 -0.9 -1.4 -0.0 -1.8
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 1.4 -1.2 0.1 -0.1 0.4
Ever used hormone-replacement therapy (HRT) 4.7 6.0 9.6 -3.1 -2.0 -1.2 -3.0
Ever had hysterectomy (womb removed) 0.3 0.4 0.8 -0.3 -0.6 -0.4 -0.9
Systolic blood pressure, automated reading 0.3 1.0 3.2 -0.4 -1.8 0.7 0.0
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.2 0.0 0.4 0.2 0.3
Angina 0.2 0.3 0.8 -0.9 -0.5 0.3 0.3
Medication for hormone replacement therapy 7.0 7.9 13.1 -3.6 -2.1 -1.8 -3.3
Vitamin and mineral supplements 0.5 0.7 1.4 0.1 -0.9 1.2 -0.8
Supplements: Zinc 2.0 2.1 3.1 1.6 1.0 -1.8 1.4
Medication: Co-codamol 0.7 0.8 1.6 1.2 0.4 -0.3 1.3
Medication: Metformin 1.2 1.7 3.5 -1.9 0.4 -1.5 -0.9
Diabetes (father) 1.4 1.7 1.8 1.3 1.3 -1.3 1.3
Diabetes (mother) 4.5 5.7 13.6 0.7 2.5 -3.7 1.5
Severe depression (siblings) 1.1 1.2 3.0 -0.8 1.0 -1.7 -0.2
Pack years adult smoking proportion 1.5 2.2 5.1 1.0 0.2 -2.3 1.6
Impedance of leg (right) 0.2 1.1 1.7 1.3 0.3 1.0 -1.2
Leg fat-free mass (left) 1.1 6.0 9.7 2.3 0.8 -3.1 2.8
Trunk fat percentage 2.8 11.0 18.8 3.3 2.3 -3.0 4.3
Hand grip strength (right) 1.5 4.0 7.8 -1.3 -2.5 0.1 -2.8
Townsend deprivation index at recruitment 1.2 1.7 4.3 0.4 1.3 -0.8 2.1
Current tobacco smoking 0.8 1.2 3.5 1.0 0.4 -0.6 1.9
Average weekly fortified wine intake 0.4 0.5 1.7 1.3 -0.6 0.1 0.2
Maternal smoking around birth 1.5 2.2 7.6 0.6 0.9 -2.8 0.2
Fed-up feelings 3.9 7.1 11.9 2.6 3.5 -1.6 2.7
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.6 3.8 1.9 0.9 -0.5 1.2
Relative age voice broke 1.5 2.2 4.6 -1.0 -1.8 0.6 -2.1
Taking other prescription medications 2.6 4.0 8.0 1.1 2.8 -1.9 1.8
Age when periods started (menarche) 0.2 0.6 1.5 1.2 -0.6 -0.2 0.7
Bilateral oophorectomy (both ovaries removed) 0.9 1.0 1.5 -1.2 -0.9 -0.7 -1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.9 5.2 -2.3 -0.2 0.5 -1.4
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.8 -0.1 0.4 0.9 -0.5
Qualifications: CSEs or equivalent 1.0 1.3 3.3 1.8 0.4 0.8 1.1
Serious illness, injury or assault to yourself 0.5 0.6 1.5 0.3 -0.1 -1.2 0.8
High blood pressure 3.1 8.6 11.6 3.4 2.4 -2.5 3.3
Hayfever, allergic rhinitis or eczema 2.2 4.8 8.6 1.5 2.9 -1.6 2.4
Multivitamins +/- minerals 0.2 0.3 0.9 -0.3 0.4 -0.9 0.1
Stomach or abdominal pain in last month 2.4 3.0 8.7 0.1 1.8 -3.0 0.5
Supplements: Glucosamine 0.1 0.1 0.3 0.0 -0.1 -0.3 0.5
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 0.6 -0.8 0.8 -0.2 -0.6
Medication: Atenolol 1.3 1.7 4.1 1.1 0.9 -2.0 0.9
Medication: Levothyroxine sodium 0.3 0.6 1.4 -1.2 0.2 -0.3 -0.8
Sitting height 1.2 8.8 21.2 3.4 0.9 -4.6 1.2
Chronic bronchitis/emphysema (father) 1.9 2.2 4.9 0.5 1.3 -2.2 1.4
High blood pressure (mother) 2.0 2.9 5.8 0.1 2.4 0.0 2.4
Body mass index (BMI) 2.4 10.1 20.9 2.1 2.0 -3.3 4.6
Impedance of leg (left) 0.2 1.1 2.2 0.8 -0.4 1.2 -1.5
Leg predicted mass (left) 1.2 6.1 9.7 2.4 0.9 -3.1 2.9
Trunk fat mass 3.0 12.9 22.6 3.6 2.2 -3.4 4.8
Waist circumference 4.5 16.5 25.8 4.2 3.4 -3.3 5.1
Number of incorrect matches in round 0.6 0.9 1.7 -1.0 -0.2 1.0 -1.3
Past tobacco smoking 0.9 1.6 2.9 -1.7 -1.5 0.5 -1.0
Alcohol usually taken with meals 2.0 3.3 6.3 -2.5 -1.9 0.9 -1.5
Nervous feelings 5.0 9.3 15.4 3.9 2.7 -3.2 2.1
Frequency of tenseness / restlessness in last 2 weeks 1.9 3.0 3.6 1.9 1.7 -1.9 1.4
Hearing difficulty/problems with background noise 5.9 9.5 17.7 1.2 4.2 -3.3 2.8
Hair/balding pattern: Pattern 2 0.7 0.9 3.1 0.3 -0.4 0.5 -1.8
Had menopause 2.6 3.2 6.2 -0.7 -2.5 -1.0 -2.3
Had other major operations 0.5 0.6 2.2 -0.1 0.3 0.4 1.5
Forced vital capacity (FVC) 0.9 3.6 7.2 -0.4 -2.5 0.9 -2.7
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.3 7.7 -2.8 -0.1 0.1 -1.3
Ever unenthusiastic/disinterested for a whole week 3.3 4.1 5.8 1.5 2.4 -2.0 2.1
Qualifications: None of the above 0.3 0.6 1.2 0.9 -0.4 -1.1 0.4
Financial difficulties in last 2 years 1.1 1.5 5.5 -0.6 -0.3 2.4 0.1
Mouth/teeth dental problems 0.7 1.0 3.0 1.7 0.9 0.5 0.2
Heart attack 2.1 2.7 5.0 1.0 2.1 -2.2 0.7
Allergy 2.6 6.0 9.7 -1.5 -3.0 1.7 -3.1
Pain all over the body in last month 0.7 0.8 2.5 -0.3 -0.7 -1.6 0.1
Diabetes (self-reported) 1.1 1.7 4.2 -0.4 1.5 -2.1 0.4
Hayfever/allergic rhinitis (self-reported) 1.3 1.7 2.9 0.6 1.2 1.4 1.7
Medication: Ramipril 0.9 1.1 1.5 1.0 1.2 -0.8 1.2
Medication: Simvastatin 0.6 1.0 1.8 1.3 0.1 -0.7 1.2
Fluid intelligence score 0.1 0.3 0.6 0.0 0.3 -0.8 0.7
Illnesses of siblings 2.1 2.9 6.4 2.3 -0.2 2.5 0.0
Neuroticism score 2.6 5.3 9.3 1.9 3.1 -2.7 1.0
Weight 2.7 13.2 20.2 3.6 2.0 -4.0 4.5
Impedance of arm (right) 0.7 3.2 7.8 0.2 -0.3 2.3 -2.8
Arm fat percentage (right) 2.1 8.2 15.9 2.6 2.3 -2.2 4.0
Trunk fat-free mass 0.6 3.7 7.8 1.8 0.4 -2.8 1.9
Hip circumference 2.3 9.9 15.9 2.8 1.5 -4.0 3.7
Time employed in main current job 0.4 0.5 1.5 0.2 1.2 -0.6 -0.1
Alcohol intake versus 10 years previously 1.8 2.7 4.7 1.3 2.2 -1.8 1.2
Father’s age at death 1.6 2.2 4.0 1.3 1.4 -1.0 2.0
Worrier / anxious feelings 3.8 7.1 11.7 3.4 2.9 -2.5 1.5
Frequency of tiredness / lethargy in last 2 weeks 1.9 3.0 6.9 0.8 2.2 0.2 2.6
Falls in the last year 0.7 0.9 2.7 -0.1 0.9 -1.6 0.4
Hair/balding pattern: Pattern 3 0.1 0.1 0.3 -0.3 -0.1 0.4 0.5
Number of live births 2.4 3.4 6.0 -2.4 -2.3 1.3 -0.9
Forced expiratory volume in 1-second (FEV1) 1.8 6.0 10.3 -1.1 -3.2 1.6 -3.2
Pulse rate 0.8 1.4 3.0 1.1 1.0 -0.6 1.7
Happiness 5.0 6.0 8.8 2.9 2.7 -0.1 3.0
Noisy workplace 2.5 3.1 4.0 1.9 1.9 -1.2 2.0
Qualifications: A levels/AS levels or equivalent 0.1 0.1 0.3 0.1 -0.2 -0.6 0.5
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 2.5 0.6 0.5 -0.2 1.6
Mouth/teeth dental problems: Dentures 0.4 0.6 1.9 -0.8 -1.4 -0.1 -0.1
Asthma 1.2 2.4 4.1 0.3 2.0 -1.4 1.8
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 1.8 1.3 -1.1 0.1 0.3
Medication: Cholesterol lowering 0.2 0.4 0.7 -0.4 0.4 -0.7 0.8
Depression (self-reported) 0.7 0.9 1.8 -0.1 1.2 -1.3 0.4
Medication: Lansoprazole 0.3 0.4 0.8 -0.9 0.8 0.2 -0.4
Prospective memory result 0.3 0.4 1.1 0.5 1.0 0.0 -0.3
Lung cancer (father) 0.6 0.7 2.0 0.2 -0.7 -1.4 -0.2
Illnesses of mother 2.4 3.0 5.3 -1.1 -1.6 2.3 -1.8
Forced expiratory volume in 1-second (FEV1), Best measure 1.6 5.0 9.3 -1.4 -3.0 0.4 -2.9
Pulse wave Arterial Stiffness index 0.2 0.3 0.7 0.2 -0.6 -0.8 0.2
Impedance of arm (left) 0.6 2.9 9.0 -0.1 -0.3 1.6 -3.0
Arm fat mass (right) 2.4 9.7 18.8 2.6 2.2 -2.9 4.3
Trunk predicted mass 0.6 3.5 7.3 1.7 0.3 -2.7 1.9
Standing height 0.4 4.3 12.9 3.6 0.1 -2.1 0.2
Length of working week for main job 2.8 3.1 6.0 -2.1 -0.2 2.5 -1.3
Exposure to tobacco smoke at home 1.0 1.2 3.2 1.2 0.2 0.1 1.8
Breastfed as a baby 1.1 1.4 2.8 -1.5 0.4 1.7 -0.8
Tense / ‘highly strung’ 0.2 0.3 0.5 0.6 0.3 -0.7 -0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 8.0 12.2 27.1 2.8 5.2 -2.2 3.1
Hair/balding pattern: Pattern 4 0.9 2.2 3.7 1.9 0.1 -1.4 1.8
Birth weight of first child 0.4 0.7 2.2 0.6 1.5 0.1 0.4
Peak expiratory flow (PEF) 2.7 6.2 9.5 -1.2 -2.7 2.6 -3.1
Pulse wave reflection index 1.9 2.4 4.5 -1.8 -2.1 0.4 -1.3
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.4 0.5 0.6 -1.2 0.5
Loud music exposure frequency 2.1 2.3 4.0 1.0 2.0 0.4 2.0
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.6 -0.2 0.2 0.8 0.2
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.2 -1.0 1.1 -0.2 0.1
Blood clot in the leg (DVT) 0.6 0.8 1.3 0.8 0.2 1.2 1.0
Medication: Paracetamol 9.8 16.2 27.5 5.2 2.7 -1.6 5.2
Headache pain in last month 3.1 5.2 7.9 2.4 2.8 -1.4 2.4
Medication for cholesterol, blood pressure or diabetes 1.4 2.3 3.5 -1.7 -1.6 0.5 -1.9
Glaucoma (self-reported) 0.0 0.0 0.0 0.1 -0.1 0.1 -0.1
Gout (self-reported) 0.3 0.5 1.2 -0.2 0.3 0.7 1.1
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 1.6 -1.3 0.2 0.0 -1.2
Medication: Amlodipine 1.0 1.4 2.7 1.2 0.2 -1.6 1.1
Medication: Ventolin 100micrograms inhaler 1.1 1.4 4.2 -0.7 2.0 0.7 0.7
Birth weight 0.6 1.4 3.4 1.9 -0.9 -1.1 0.3
Chronic bronchitis/emphysema (mother) 1.2 1.5 4.3 0.1 -1.1 -2.1 -0.6
High blood pressure (siblings) 1.7 2.4 5.1 -2.3 -0.0 -2.2 0.1
Forced vital capacity (FVC), Best measure 0.7 2.5 5.0 -0.2 -2.2 -0.0 -2.2
Body fat percentage 2.6 10.3 19.2 3.0 2.1 -2.9 4.4
Leg fat percentage (right) 2.8 10.2 19.3 2.9 1.9 -3.1 4.4
Arm fat-free mass (right) 1.2 6.3 12.1 2.0 0.4 -3.5 3.0
Exposure to tobacco smoke outside home 6.5 8.6 15.9 2.1 2.9 -2.4 4.0
Comparative body size at age 10 0.3 0.9 2.3 -1.0 -1.5 0.3 -0.2
Number of full brothers 0.6 0.8 2.0 -0.1 1.0 -1.4 -0.2
Worry too long after embarrassment 1.2 2.0 3.2 -1.6 1.4 -0.5 -1.8
Seen a psychiatrist for nerves, anxiety, tension or depression 4.6 6.0 11.4 1.3 3.4 -2.7 2.0
Wheeze or whistling in the chest in last year 4.7 8.3 15.8 1.1 4.0 -1.9 3.6
Number of children fathered 2.0 2.3 3.0 -1.7 -1.3 1.2 -1.7
Reason for reducing amount of alcohol drunk: Health precaution 2.1 2.4 7.0 -0.8 -0.4 2.7 -1.4
Age at first live birth 0.5 0.9 2.7 0.2 -0.9 0.2 -1.6
Pulse wave peak to peak time 0.1 0.1 0.2 0.0 0.4 0.4 -0.3
Health satisfaction 1.6 2.1 5.6 0.8 2.4 -0.8 1.2
Shortness of breath walking on level ground 0.3 0.3 0.7 0.2 0.8 -0.1 0.8
Qualifications: College or University degree 0.5 1.4 2.4 -1.1 -1.6 1.0 -1.0
Eye problems/disorders: None of the above 0.2 0.3 0.5 0.5 0.5 0.2 0.7
Mouth/teeth dental problems: Loose teeth 0.7 0.8 1.2 0.1 1.0 -1.0 1.1
Emphysema/chronic bronchitis 3.6 4.0 6.4 1.6 2.5 -1.3 2.3
Medication for pain relief, constipation, heartburn 7.0 11.9 21.7 -4.7 -1.5 1.7 -4.6
Neck or shoulder pain in last month 0.3 0.4 1.0 0.4 1.0 -0.5 0.4
Medication: Blood pressure 1.8 3.3 4.2 2.0 2.0 -1.0 2.1
Angina (self-reported) 0.4 0.5 0.8 -0.9 -0.7 0.8 0.3
Migraine (self-reported) 4.2 5.2 9.2 3.0 1.7 -2.4 1.7
Medication: Ibuprofen 1.1 1.3 2.5 1.6 -1.5 -0.5 0.2
Medication: Allopurinol 0.1 0.2 0.4 0.4 0.1 -0.4 0.6
Medication: Omeprazole 1.2 1.4 4.0 1.1 0.7 -0.2 2.0
Medication: Seretide 50 evohaler 0.8 1.0 2.4 0.5 1.6 -0.9 0.7
Mean time to correctly identify matches 0.2 0.4 1.4 0.5 0.3 -1.2 -0.1
Heart disease (mother) 2.0 2.4 5.6 1.5 1.4 -0.3 2.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.1 1.1 0.7 0.8 -0.0
Whole body fat mass 2.9 12.0 21.7 3.3 2.0 -3.4 4.7
Leg fat mass (right) 3.3 12.6 23.1 3.3 1.9 -3.6 4.8
Arm predicted mass (right) 1.3 6.6 11.3 2.0 0.7 -3.3 3.4
Pulse rate, automated reading 0.9 3.0 6.2 1.2 0.4 -2.5 2.1
Alcohol intake frequency. 0.5 1.1 2.1 0.3 1.5 -1.0 1.1
Comparative height size at age 10 0.1 0.7 1.8 0.9 -1.3 -0.5 0.4
Number of full sisters 0.9 1.1 2.3 1.5 0.0 0.2 1.5
Suffer from ‘nerves’ 6.0 9.5 15.7 4.0 3.1 -1.9 3.0
Overall health rating 2.0 4.4 5.5 1.7 2.0 -2.2 2.3
Chest pain or discomfort 1.0 1.4 3.8 -1.1 1.9 0.3 0.8
Had major operations 0.4 0.4 1.6 -1.3 -0.1 -0.4 -0.0
Age at last live birth 0.7 1.1 2.6 -0.7 -0.6 1.0 -1.6
Family relationship satisfaction 2.6 3.2 6.0 2.5 1.9 -0.5 1.6
Leg pain on walking 0.2 0.3 0.8 -0.2 0.4 0.9 -0.0
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.8 2.0 -0.6 -0.9 -0.3 -1.4
Commuting to job workplace: Car/motor vehicle 0.7 0.8 2.4 -1.6 0.2 -0.8 0.1
Illness, injury, bereavement, stress in last 2 years 1.2 1.5 3.3 -1.1 -0.2 1.2 -1.8
Medication: Aspirin 1.3 1.7 2.8 0.5 1.4 -1.7 1.4
Supplements: Vitamin C 0.9 1.1 1.8 1.3 1.3 -0.5 0.9
Knee pain experienced in last month 0.6 0.9 1.6 1.3 1.2 -0.6 0.4
Hypertension (Self-reported) 2.7 7.5 11.0 3.1 2.3 -2.0 3.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 1.3 -0.9 1.1 -0.5 0.7
Illnesses of father: Heart disease 0.4 0.6 1.4 -0.1 -0.4 1.2 0.9
Illnesses of siblings: Diabetes 4.2 5.2 11.6 1.3 1.9 -3.4 2.0
Smoking status: Previous 0.2 0.3 1.1 1.0 0.3 -0.1 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.2 4.0 2.0 -0.3 -0.0 0.9
Whole body fat-free mass 0.9 4.9 8.8 2.1 0.6 -3.0 2.5
Leg fat-free mass (right) 0.9 4.5 7.9 1.9 0.4 -2.8 2.6
Arm fat percentage (left) 2.0 8.0 15.4 2.3 2.2 -2.5 3.9
Average weekly red wine intake 0.5 0.8 2.1 -0.7 0.7 1.4 0.1
Handedness (chirality/laterality): Left-handed 0.2 0.3 0.5 -0.6 0.5 0.7 -0.0
Mood swings 0.8 1.4 3.8 0.6 2.0 -0.3 1.2
Loneliness, isolation 0.7 1.0 2.7 0.1 1.0 -1.6 0.6
Long-standing illness, disability or infirmity 5.7 8.8 15.4 2.2 3.9 -3.1 2.3
Ever had bowel cancer screening 2.0 2.4 4.1 -1.3 -0.7 -1.8 -2.0
Diabetes diagnosed by doctor 1.9 3.1 6.9 -0.2 2.3 -2.6 0.4
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.2 2.5 0.9 0.8 -1.6 0.9
Friendships satisfaction 1.1 1.4 2.4 1.3 1.2 0.3 1.5
Qualifications: nursing, teaching 0.0 0.1 0.1 -0.3 0.0 -0.3 -0.1
Commuting to job workplace: Walk 0.4 0.4 0.6 0.8 -0.4 0.8 -0.6
Eye problems/disorders: Cataract 0.5 0.6 0.8 -0.8 -0.9 0.3 -0.8
Mouth/teeth dental problems: Mouth ulcers 1.1 1.7 6.5 -0.5 -0.1 -2.5 0.2
Medication for cholesterol 0.9 1.3 4.2 0.7 0.7 2.0 0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 4.3 5.0 9.1 2.8 -0.1 -1.7 3.0
Back pain experienced in last month 5.4 7.8 13.4 3.7 2.9 -2.0 2.4
Mineral and other dietary supplements 0.5 0.7 1.3 1.0 -0.0 1.1 0.7
Breast cancer (self-reported) 0.2 0.2 0.4 0.1 0.2 -0.6 0.7
Asthma (self-reported) 1.3 2.5 4.2 0.3 2.1 -1.4 1.9
Osteoporosis (self-reported) 0.4 0.5 1.4 -1.2 0.4 0.4 -0.4
Osteoarthritis (self-reported) 0.9 1.2 3.9 0.5 0.2 -0.7 2.0
Medication: Aspirin 1.0 1.3 2.8 0.6 0.6 -1.7 1.3
Medication: Gliclazide 1.8 2.0 3.0 -1.6 1.2 -1.7 -1.1
Illnesses of father: None of the above (group 1) 0.7 0.8 2.2 -1.0 0.1 1.5 -0.5
Smoking status: Current 0.9 1.5 3.6 1.2 0.7 -0.7 1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.4 7.2 11.6 -2.3 -3.4 0.3 -3.4
Whole body water mass 0.8 4.5 8.1 1.9 0.6 -2.9 2.4
Leg predicted mass (right) 0.8 4.4 7.4 1.9 0.3 -2.7 2.5
Arm fat mass (left) 2.2 8.9 16.1 2.4 1.8 -3.2 4.0
Number of self-reported non-cancer illnesses 4.9 8.5 14.0 2.4 3.7 -1.5 3.5
Average weekly champagne plus white wine intake 0.5 0.7 1.9 -1.4 -0.5 0.6 -0.7
Miserableness 1.5 2.6 5.4 0.6 2.3 -2.1 0.4
Guilty feelings 2.5 3.8 8.7 -3.0 -0.2 -1.3 -2.2
Wears glasses or contact lenses 1.3 1.5 2.6 1.0 1.6 -1.2 0.8
Ever taken oral contraceptive pill 0.8 0.8 1.8 0.2 0.0 1.2 1.4
Hearing aid user 0.5 0.6 0.9 0.9 0.8 -0.9 0.3
Mother’s age at death 1.3 1.6 4.0 -1.4 -0.8 0.0 -2.0
Financial situation satisfaction 1.6 2.0 2.6 1.5 1.6 -0.8 1.5
Tinnitus: Yes, now most or all of the time 0.1 0.2 0.4 -0.3 -0.6 -0.4 0.1
Commuting to job workplace: Public transport 1.0 1.1 1.7 1.3 0.5 1.1 1.2
Eye problems/disorders: Glaucoma 0.5 0.5 1.6 -0.5 -1.3 0.5 0.0
Medication: Blood pressure 1.3 2.5 3.7 1.4 0.9 -1.9 1.8
Pain type(s) experienced in last month: Hip pain 2.6 3.3 7.0 1.6 1.0 -2.6 1.6
Supplements: Fish oil (including cod liver oil) 0.4 0.5 0.8 0.7 0.2 -0.9 0.7
High cholesterol (Self-reported) 0.4 0.7 1.5 0.1 -0.6 -1.0 1.2
Medication: Bendroflumethiazide 0.7 1.0 1.8 0.6 1.2 -0.6 1.3
Medication: Paracetamol 6.5 10.1 18.9 4.4 1.6 -0.9 4.3
Medication: Lisinopril 0.9 1.2 3.8 1.9 0.3 -1.0 0.1
Medication: Atorvastatin 0.6 0.8 1.5 -0.2 0.9 -0.8 1.2
Illnesses of father: High blood pressure 1.3 1.6 5.0 -0.4 0.4 -2.2 -1.0
Alcohol drinker status: Never 1.2 1.4 4.5 -0.4 -2.1 -0.2 -1.0
Ever smoked 2.8 4.8 6.7 2.2 2.3 -1.6 2.6
Basal metabolic rate 1.2 6.7 10.4 2.5 0.9 -3.2 3.1
Leg fat percentage (left) 2.5 9.1 17.9 2.6 1.5 -3.1 4.2
Arm fat-free mass (left) 1.2 6.3 10.4 2.2 0.5 -3.2 3.1
Number of operations (self-reported) 0.4 0.6 1.3 -0.5 0.1 -1.0 1.2
Average weekly beer plus cider intake 0.5 0.7 1.6 -0.3 -1.3 0.0 -1.1
Irritability 0.8 1.3 3.5 0.6 1.2 0.1 1.9
Risk taking 0.7 1.0 2.6 -1.6 0.2 -1.2 -0.3
Ever had prostate specific antigen (PSA) test 0.6 0.7 2.5 -0.3 1.6 -0.2 0.4
Fractured/broken bones in last 5 years 0.1 0.2 0.3 0.6 0.3 -0.3 -0.3
Age started oral contraceptive pill 1.0 1.2 2.4 -0.4 1.6 -1.5 0.4
Diastolic blood pressure, automated reading 0.4 1.2 2.5 0.6 -1.6 -1.4 0.1
Ever depressed for a whole week 2.6 3.2 7.2 -0.2 2.7 -1.8 1.6
Unable to work because of sickness or disability 0.3 0.4 0.7 0.2 0.7 -0.8 0.8
Commuting to job workplace: Cycle 0.7 0.8 1.3 1.2 -1.0 -0.2 -0.8
Myopia 0.7 1.1 3.9 0.3 2.0 0.1 0.5
Vascular/heart problems diagnosed by doctor 2.5 6.7 9.4 -3.1 -2.1 1.9 -3.1
Cholesterol lowering medication 2.2 3.2 5.8 1.7 0.8 -2.4 1.9
Medication: Omeprazole (e.g. Zanprol) 1.7 2.1 5.7 1.2 1.0 0.1 2.4
Pain experienced in last month 2.9 4.8 8.9 -2.1 -1.7 3.0 -1.7
Supplements: Calcium 0.3 0.3 0.9 -0.9 0.0 0.1 -0.5
Basal cell carcinoma (self-reported) 0.2 0.2 0.6 -0.2 0.5 -0.8 0.2
Heart attack/myocardial infarction (self-reported) 2.1 2.7 5.6 0.8 2.0 -2.4 0.6
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 1.5 0.7 0.2 1.2 1.2
Heart disease (siblings) 0.5 0.6 2.0 -0.6 -0.1 -1.4 -0.2
Alcohol drinker status: Previous 0.7 0.8 2.4 0.8 1.6 0.3 -0.3
Pack years of smoking 1.6 2.4 4.8 1.2 0.2 -2.2 1.8
Impedance of whole body 0.3 1.7 3.8 0.7 -0.3 1.6 -2.0
Leg fat mass (left) 3.1 11.9 21.7 3.1 1.7 -3.7 4.7
Arm predicted mass (left) 1.4 7.3 11.6 2.6 0.8 -3.2 3.4