Best TWAS P=1.63e-18 · Best GWAS P=1.68e-18 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | RP11-395P17.3 | 0.32 | 0.03 | lasso | 4 | 0.06 | 1.1e-02 | 2.4 | 5.6 | 2.1e-08 | 0.02 | 0.05 | 0.13 | TRUE |
| 2 | GTEx | Breast Mammary Tissue (Male) | RPL12 | 0.15 | 0.14 | lasso | 3 | 0.17 | 1.1e-04 | 5.3 | -5.3 | 8.8e-08 | -0.05 | 0.09 | 0.16 | TRUE |
| 3 | GTEx | Colon Transverse | PKN3 | 0.37 | 0.35 | lasso | 3 | 0.34 | 6.2e-17 | -8.8 | -8.7 | 2.6e-18 | 1.00 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Heart Atrial Appendage | ZNF79 | 0.12 | 0.10 | lasso | 1 | 0.08 | 1.7e-04 | 5.2 | 5.2 | 1.9e-07 | 0.06 | 0.23 | 0.18 | FALSE |
| 5 | GTEx | Liver | PKN3 | 0.63 | 0.52 | lasso | 4 | 0.50 | 5.1e-16 | -8.8 | -8.8 | 1.6e-18 | 1.00 | 0.00 | 1.00 | TRUE |
| 6 | GTEx | Muscle Skeletal | LRSAM1 | 0.09 | 0.11 | lasso | 2 | 0.11 | 3.8e-11 | 5.2 | -5.2 | 2.2e-07 | -0.07 | 0.69 | 0.31 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | ZNF79 | 0.09 | 0.04 | lasso | 5 | 0.04 | 2.7e-04 | 4.9 | 5.3 | 1.1e-07 | 0.07 | 0.75 | 0.16 | FALSE |
| 8 | GTEx | Small Intestine Terminal Ileum | PKN3 | 0.28 | 0.39 | lasso | 2 | 0.36 | 5.6e-09 | -8.8 | -8.8 | 1.7e-18 | 1.00 | 0.00 | 1.00 | FALSE |
| 9 | GTEx | Stomach | PKN3 | 0.22 | 0.26 | lasso | 2 | 0.25 | 4.4e-12 | -8.8 | -8.8 | 1.7e-18 | 1.00 | 0.00 | 1.00 | FALSE |
| 10 | YFS | Blood | PKN3 | 0.07 | 0.05 | lasso | 3 | 0.05 | 1.3e-16 | -5.3 | -5.5 | 2.9e-08 | 0.65 | 0.00 | 1.00 | FALSE |
| 11 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ZNF79 | 0.08 | 0.09 | enet | 15 | 0.10 | 1.1e-08 | 5.1 | 5.3 | 1.4e-07 | 0.07 | 0.01 | 0.99 | FALSE |
| 12 | The Cancer Genome Atlas | Colon Adenocarcinoma | AK1 | 0.10 | 0.03 | enet | 7 | 0.03 | 4.2e-03 | 4.2 | -6.4 | 1.5e-10 | 0.03 | 0.01 | 0.88 | TRUE |
| 13 | The Cancer Genome Atlas | Colon Adenocarcinoma | ZNF79 | 0.12 | 0.08 | enet | 5 | 0.11 | 7.9e-07 | 5.2 | 5.2 | 1.9e-07 | 0.07 | 0.01 | 0.99 | FALSE |
| 14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ZNF79 | 0.07 | 0.07 | blup | 50 | 0.06 | 1.7e-07 | 4.4 | 5.1 | 3.0e-07 | 0.09 | 0.05 | 0.93 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | C9orf16 | 0.09 | 0.03 | blup | 34 | 0.04 | 2.5e-03 | 2.9 | 5.3 | 8.9e-08 | -0.04 | 0.00 | 0.15 | TRUE |
| 16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ZNF79 | 0.05 | 0.03 | lasso | 6 | 0.04 | 6.5e-05 | 5.2 | 5.2 | 1.8e-07 | 0.07 | 0.01 | 0.98 | FALSE |
| 17 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | PKN3 | 0.07 | 0.03 | enet | 5 | 0.05 | 3.3e-03 | -8.8 | -7.6 | 2.6e-14 | 0.90 | 0.00 | 0.94 | FALSE |
| 18 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | DPM2 | 0.03 | 0.01 | blup | 29 | 0.02 | 5.3e-03 | 6.3 | 5.1 | 2.8e-07 | -0.01 | 0.00 | 0.84 | FALSE |
| 19 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | AK1 | 0.17 | 0.01 | enet | 7 | 0.05 | 3.3e-03 | 5.6 | -6.2 | 4.2e-10 | 0.07 | 0.00 | 0.82 | FALSE |
| 20 | The Cancer Genome Atlas | Thyroid Carcinoma | ZNF79 | 0.04 | 0.04 | lasso | 3 | 0.04 | 9.1e-05 | 5.1 | 5.1 | 2.9e-07 | 0.07 | 0.01 | 0.98 | FALSE |