Best TWAS P=8.7e-12 · Best GWAS P=8.19e-11 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | APBB1IP | 0.19 | 0.16 | enet | 5 | 0.17 | 2.6e-13 | 6.5 | 6.5 | 6.8e-11 | 1.00 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | APBB1IP | 0.30 | 0.20 | lasso | 10 | 0.20 | 4.9e-15 | 6.5 | 6.8 | 8.7e-12 | 0.97 | 0.01 | 0.99 | TRUE |
| 3 | GTEx | Esophagus Muscularis | APBB1IP | 0.12 | 0.09 | lasso | 3 | 0.08 | 1.6e-05 | 6.5 | 6.5 | 7.3e-11 | 0.99 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Pituitary | APBB1IP | 0.53 | 0.37 | lasso | 8 | 0.38 | 1.6e-10 | 6.5 | 6.0 | 1.9e-09 | 0.99 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Stomach | APBB1IP | 0.31 | 0.05 | lasso | 4 | 0.05 | 2.9e-03 | 6.1 | 5.8 | 8.2e-09 | 0.86 | 0.02 | 0.95 | FALSE |
| 6 | METSIM | Adipose | APBB1IP | 0.07 | 0.04 | lasso | 6 | 0.03 | 8.2e-06 | 6.5 | 6.2 | 5.2e-10 | 0.97 | 0.01 | 0.99 | FALSE |
| 7 | YFS | Blood | APBB1IP | 0.08 | 0.06 | lasso | 3 | 0.06 | 1.3e-18 | -6.1 | -6.2 | 7.8e-10 | -0.59 | 0.07 | 0.93 | FALSE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | APBB1IP | 0.04 | 0.03 | blup | 103 | 0.03 | 4.6e-06 | 6.5 | 6.3 | 2.2e-10 | 0.82 | 0.01 | 0.99 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ACBD5 | 0.04 | 0.02 | blup | 59 | 0.03 | 3.9e-04 | 3.8 | 5.7 | 1.0e-08 | 0.08 | 0.00 | 0.27 | TRUE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | APBB1IP | 0.06 | 0.07 | lasso | 2 | 0.06 | 1.0e-07 | 6.1 | 6.1 | 1.0e-09 | 0.92 | 0.02 | 0.98 | FALSE |