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chr10:28,113,533-29,671,014

Best TWAS P=1.52e-38 · Best GWAS P=1.53e-39 conditioned to 0.00155

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
5	GTEx	Artery Coronary	WAC-AS1	0.41	0.21	lasso	6	0.19	4.0e-07	-12.8	-13.0	2.2e-38	0.91	0.06	0.94	TRUE
20	GTEx	Liver	WAC-AS1	0.37	0.34	lasso	3	0.34	3.1e-10	-12.8	-13.0	1.5e-38	0.97	0.03	0.97	FALSE
12	GTEx	Cells Transformed fibroblasts	WAC-AS1	0.58	0.62	lasso	12	0.64	9.7e-62	-12.8	-12.9	4.0e-38	0.94	0.07	0.93	FALSE
30	GTEx	Testis	WAC-AS1	0.45	0.47	lasso	3	0.48	4.3e-24	-12.8	-12.9	4.6e-38	0.96	0.04	0.96	FALSE
4	GTEx	Artery Aorta	WAC-AS1	0.39	0.38	lasso	6	0.38	3.1e-22	-12.8	-12.9	5.0e-38	0.93	0.05	0.95	FALSE
32	GTEx	Vagina	WAC-AS1	0.55	0.25	lasso	5	0.22	1.0e-05	-13.0	-12.9	5.2e-38	0.92	0.02	0.96	FALSE
23	GTEx	Nerve Tibial	WAC-AS1	0.45	0.55	lasso	5	0.56	1.4e-46	-12.8	-12.9	8.2e-38	0.95	0.04	0.96	FALSE
13	GTEx	Colon Sigmoid	WAC-AS1	0.36	0.23	lasso	9	0.22	2.6e-08	-13.0	-12.9	8.3e-38	0.92	0.02	0.98	FALSE
9	GTEx	Breast Mammary Tissue	WAC-AS1	0.29	0.32	lasso	2	0.31	2.1e-16	-12.8	-12.8	9.7e-38	0.95	0.04	0.96	FALSE
1	GTEx	Adipose Subcutaneous	WAC-AS1	0.39	0.46	lasso	5	0.45	1.1e-40	-12.8	-12.8	1.0e-37	0.94	0.05	0.95	FALSE
24	GTEx	Pancreas	WAC-AS1	0.45	0.33	lasso	8	0.34	6.4e-15	-12.8	-12.8	1.1e-37	0.94	0.04	0.96	FALSE
6	GTEx	Artery Tibial	WAC-AS1	0.44	0.43	lasso	4	0.44	4.0e-37	-13.0	-12.8	1.7e-37	0.95	0.02	0.98	FALSE
2	GTEx	Adipose Visceral Omentum	WAC-AS1	0.21	0.17	enet	16	0.18	2.0e-09	-12.8	-12.8	2.5e-37	0.91	0.04	0.96	FALSE
28	GTEx	Stomach	WAC-AS1	0.39	0.31	lasso	8	0.33	1.1e-16	-12.8	-12.8	2.7e-37	0.91	0.06	0.94	FALSE
10	GTEx	Breast Mammary Tissue (Female)	WAC-AS1	0.30	0.30	enet	13	0.33	1.7e-10	-12.8	-12.7	3.2e-37	0.94	0.04	0.96	FALSE
3	GTEx	Adrenal Gland	WAC-AS1	0.28	0.19	lasso	4	0.14	7.2e-06	-12.8	-12.6	1.6e-36	0.93	0.05	0.94	FALSE
26	GTEx	Skin Sun Exposed Lower leg	WAC-AS1	0.34	0.39	enet	21	0.45	7.7e-41	-13.0	-12.6	3.3e-36	0.90	0.02	0.98	FALSE
15	GTEx	Esophagus Gastroesophageal Junction	WAC-AS1	0.37	0.16	lasso	6	0.20	9.1e-08	-11.8	-12.6	3.8e-36	0.88	0.09	0.91	FALSE
25	GTEx	Skin Not Sun Exposed Suprapubic	WAC-AS1	0.48	0.48	enet	37	0.56	6.1e-37	-13.0	-12.5	1.1e-35	0.87	0.02	0.98	FALSE
16	GTEx	Esophagus Mucosa	WAC-AS1	0.52	0.44	lasso	16	0.51	1.2e-38	-12.8	-12.4	2.2e-35	0.87	0.05	0.95	FALSE
18	GTEx	Heart Atrial Appendage	WAC-AS1	0.18	0.12	enet	6	0.15	2.5e-07	-13.0	-12.3	9.5e-35	0.89	0.02	0.98	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	WAC-AS1	0.45	0.36	enet	12	0.41	1.1e-14	-12.8	-12.3	1.0e-34	0.85	0.04	0.96	FALSE
37	YFS	Blood	WAC	0.06	0.08	bslmm	649	0.08	2.2e-24	-11.1	12.0	5.1e-33	-0.86	0.97	0.03	FALSE
21	GTEx	Lung	WAC-AS1	0.32	0.13	enet	26	0.24	4.7e-18	-12.8	-11.9	1.2e-32	0.83	0.07	0.93	FALSE
35	ROSMAP	Brain Pre-frontal Cortex	WAC	0.21	0.29	lasso	5	0.29	5.9e-37	-11.9	-11.8	4.8e-32	0.87	1.00	0.00	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	WAC	0.06	0.04	lasso	3	0.03	4.2e-04	-11.9	-11.6	3.5e-31	0.88	0.09	0.62	FALSE
31	GTEx	Thyroid	WAC-AS1	0.21	0.13	enet	12	0.20	1.6e-15	-12.8	-11.3	1.5e-29	0.79	0.05	0.95	FALSE
14	GTEx	Colon Transverse	WAC-AS1	0.36	0.17	enet	16	0.31	3.6e-15	-7.4	-11.2	3.6e-29	0.76	0.08	0.92	FALSE
8	GTEx	Brain Nucleus accumbens basal ganglia	WAC-AS1	0.38	0.07	enet	11	0.08	4.3e-03	-13.0	-11.1	1.8e-28	0.81	0.01	0.91	FALSE
7	GTEx	Brain Hippocampus	WAC-AS1	0.29	0.01	enet	10	-0.01	8.5e-01	-8.6	-10.7	7.6e-27	0.77	0.05	0.41	FALSE
17	GTEx	Esophagus Muscularis	WAC-AS1	0.37	0.29	enet	32	0.38	5.5e-24	-12.8	-10.5	9.7e-26	0.78	0.05	0.95	FALSE
38	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	WAC	0.11	0.04	blup	83	0.07	1.3e-03	-11.8	-10.4	3.4e-25	0.78	0.07	0.40	FALSE
22	GTEx	Muscle Skeletal	WAC-AS1	0.29	0.15	enet	26	0.22	8.7e-21	-7.4	-10.0	1.5e-23	0.71	0.34	0.66	FALSE
36	ROSMAP	Brain Pre-frontal Cortex	WAC-AS1	0.39	0.35	bslmm	570	0.49	1.8e-72	-7.4	-9.8	1.8e-22	0.67	1.00	0.00	FALSE
19	GTEx	Heart Left Ventricle	WAC-AS1	0.39	0.08	lasso	8	0.20	1.3e-10	-7.4	-9.6	5.3e-22	0.63	0.44	0.56	FALSE
39	The Cancer Genome Atlas	Prostate Adenocarcinoma	WAC	0.07	0.02	blup	83	0.06	8.7e-07	-5.4	-8.2	3.0e-16	0.66	0.52	0.30	FALSE
34	ROSMAP	Brain Pre-frontal Cortex	BAMBI	0.07	0.05	lasso	3	0.04	2.8e-06	-8.4	-7.6	3.3e-14	0.51	0.93	0.04	FALSE
27	GTEx	Spleen	WAC-AS1	0.38	0.22	lasso	5	0.15	1.3e-04	4.3	-5.8	7.1e-09	0.33	0.39	0.20	FALSE
29	GTEx	Testis	WAC	0.23	0.05	enet	11	0.09	1.3e-04	5.1	5.7	1.3e-08	-0.36	0.60	0.03	FALSE
33	GTEx	Whole Blood	WAC-AS1	0.19	0.07	lasso	7	0.05	1.2e-05	4.2	-5.4	7.2e-08	0.25	0.69	0.19	FALSE