Best TWAS P=4.83e-12 · Best GWAS P=6.26e-12 conditioned to 0.023
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Muscle Skeletal | DNAJC12 | 0.05 | 0.04 | enet | 9 | 0.02 | 2.7e-03 | -6.1 | -6.9 | 4.8e-12 | 0.80 | 0.13 | 0.83 | TRUE |
| 2 | GTEx | Testis | DNAJC12 | 0.22 | 0.15 | lasso | 6 | 0.12 | 5.2e-06 | -4.4 | -5.5 | 4.9e-08 | 0.64 | 0.12 | 0.81 | FALSE |
| 3 | GTEx | Testis | HERC4 | 0.12 | 0.08 | lasso | 2 | 0.05 | 2.0e-03 | -5.2 | -5.2 | 1.6e-07 | 0.77 | 0.05 | 0.78 | FALSE |
| 4 | GTEx | Whole Blood | SIRT1 | 0.07 | 0.07 | enet | 7 | 0.06 | 1.3e-06 | -6.5 | -6.5 | 1.0e-10 | 0.50 | 0.05 | 0.95 | FALSE |
| 5 | YFS | Blood | HERC4 | 0.03 | 0.02 | bslmm | 402 | 0.03 | 6.2e-10 | -5.2 | -5.6 | 1.7e-08 | 0.72 | 0.24 | 0.76 | FALSE |
| 6 | YFS | Blood | SIRT1 | 0.10 | 0.20 | lasso | 5 | 0.20 | 1.4e-63 | -6.7 | -6.6 | 3.9e-11 | 0.51 | 0.02 | 0.98 | FALSE |
| 7 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | SIRT1 | 0.02 | 0.02 | blup | 42 | 0.01 | 6.3e-02 | -6.6 | -6.2 | 5.4e-10 | 0.44 | 0.01 | 0.87 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SIRT1 | 0.03 | 0.02 | blup | 42 | 0.03 | 3.2e-04 | -6.6 | -5.4 | 5.4e-08 | 0.37 | 0.02 | 0.94 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Adenocarcinoma | HERC4 | 0.03 | 0.02 | blup | 77 | 0.01 | 6.7e-03 | -6.0 | -5.7 | 9.9e-09 | 0.42 | 0.05 | 0.87 | FALSE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SIRT1 | 0.05 | 0.06 | enet | 8 | 0.06 | 1.7e-06 | -6.5 | -6.7 | 2.5e-11 | 0.59 | 0.01 | 0.99 | FALSE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | HERC4 | 0.04 | 0.02 | lasso | 4 | 0.03 | 3.1e-04 | -5.9 | -6.5 | 8.3e-11 | 0.57 | 0.03 | 0.94 | FALSE |
| 12 | The Cancer Genome Atlas | Thyroid Carcinoma | SIRT1 | 0.04 | 0.05 | lasso | 1 | 0.04 | 2.0e-04 | -6.6 | -6.6 | 3.1e-11 | 0.51 | 0.01 | 0.99 | FALSE |