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chr10:63,870,456-66,034,105

Best TWAS P=1.34e-58 · Best GWAS P=3.31e-57 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
6	GTEx	Esophagus Mucosa	NRBF2	0.14	0.11	lasso	10	0.11	6.4e-08	-15.57	16.1	1.3e-58	-0.96	0.01	0.99	TRUE
28	The Cancer Genome Atlas	Brain Lower Grade Glioma	ADO	0.07	0.06	blup	53	0.05	2.5e-06	-6.35	-7.1	1.0e-12	-0.07	0.68	0.32	TRUE
17	ROSMAP	Brain Pre-frontal Cortex	NRBF2	0.34	0.46	lasso	5	0.46	3.1e-66	-15.75	15.8	2.8e-56	-0.98	0.01	0.99	FALSE
21	The Cancer Genome Atlas	Breast Invasive Carcinoma	NRBF2	0.05	0.06	lasso	2	0.06	5.5e-12	-15.75	15.7	1.1e-55	-0.97	0.00	1.00	FALSE
4	GTEx	Brain Frontal Cortex BA9	NRBF2	0.25	0.17	lasso	6	0.16	6.1e-05	-15.75	15.7	1.6e-55	-0.97	0.01	0.98	FALSE
37	The Cancer Genome Atlas	Prostate Adenocarcinoma	NRBF2	0.08	0.09	lasso	6	0.08	9.7e-09	-15.92	15.7	1.7e-55	-0.98	0.00	1.00	FALSE
29	The Cancer Genome Atlas	Brain Lower Grade Glioma	NRBF2	0.08	0.08	enet	6	0.08	4.3e-09	-15.75	15.6	5.0e-55	-0.96	0.00	1.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	REEP3	0.05	0.05	lasso	3	0.04	5.9e-06	-15.93	-15.6	1.2e-54	0.98	0.01	0.99	FALSE
12	GTEx	Testis	NRBF2	0.14	0.08	lasso	12	0.09	6.7e-05	-15.57	15.5	7.5e-54	-0.98	0.01	0.98	FALSE
3	GTEx	Brain Cortex	NRBF2	0.30	0.26	enet	24	0.21	1.4e-06	15.06	15.4	9.7e-54	-0.96	0.02	0.98	FALSE
25	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NRBF2	0.04	0.04	enet	5	0.03	1.3e-04	-15.92	15.4	1.6e-53	-0.96	0.00	0.99	FALSE
9	GTEx	Nerve Tibial	NRBF2	0.08	0.09	enet	11	0.06	5.0e-05	-15.57	15.2	2.0e-52	-0.93	0.01	0.99	FALSE
31	The Cancer Genome Atlas	Lung Adenocarcinoma	NRBF2	0.09	0.06	enet	8	0.07	2.7e-08	-15.92	15.0	9.2e-51	-0.93	0.00	1.00	FALSE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	JMJD1C	0.04	0.01	blup	88	0.01	9.7e-03	-15.92	14.5	1.2e-47	-0.87	0.01	0.92	FALSE
26	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NRBF2	0.10	0.06	lasso	7	0.08	3.5e-09	9.93	14.3	1.8e-46	-0.87	0.01	0.99	FALSE
23	The Cancer Genome Atlas	Glioblastoma Multiforme	JMJD1C	0.11	0.02	blup	87	0.05	1.4e-02	-15.92	14.3	3.3e-46	-0.88	0.01	0.74	FALSE
34	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	NRBF2	0.18	0.13	enet	11	0.08	2.5e-04	-15.92	14.1	4.8e-45	-0.88	0.00	1.00	FALSE
24	The Cancer Genome Atlas	Glioblastoma Multiforme	NRBF2	0.17	0.09	enet	10	0.13	1.1e-04	-15.75	13.9	6.6e-44	-0.88	0.01	0.94	FALSE
39	The Cancer Genome Atlas	Thyroid Carcinoma	NRBF2	0.14	0.10	enet	16	0.09	8.1e-09	-15.92	13.9	1.3e-43	-0.91	0.00	1.00	FALSE
22	The Cancer Genome Atlas	Colon Adenocarcinoma	NRBF2	0.13	0.10	enet	11	0.09	4.9e-06	-15.75	13.7	1.9e-42	-0.83	0.00	0.99	FALSE
35	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	NRBF2	0.08	0.02	blup	40	0.04	8.6e-03	-15.75	13.5	9.0e-42	-0.88	0.00	0.90	FALSE
30	The Cancer Genome Atlas	Brain Lower Grade Glioma	REEP3	0.04	0.04	blup	59	0.05	1.8e-06	9.68	-13.4	3.3e-41	0.81	0.03	0.97	FALSE
11	GTEx	Stomach	NRBF2	0.09	0.04	lasso	6	0.03	1.6e-02	10.07	12.7	4.8e-37	-0.74	0.08	0.38	FALSE
15	GTEx	Thyroid	NRBF2	0.11	0.05	lasso	3	0.07	2.5e-06	5.47	12.5	8.2e-36	-0.75	0.02	0.97	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	REEP3	0.10	0.11	lasso	8	0.09	7.2e-12	11.12	-12.4	4.2e-35	0.75	0.96	0.04	FALSE
20	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	NRBF2	0.07	0.04	blup	42	0.02	7.3e-03	-15.92	12.2	2.1e-34	-0.83	0.00	0.99	FALSE
5	GTEx	Cells Transformed fibroblasts	JMJD1C	0.09	0.01	enet	18	0.07	8.6e-06	12.32	11.5	8.7e-31	-0.62	0.15	0.63	FALSE
32	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	NRBF2	0.09	0.02	enet	6	0.04	1.4e-05	3.85	10.7	1.0e-26	-0.72	0.07	0.89	FALSE
33	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	LOC84989	0.10	0.05	blup	19	0.04	7.7e-03	6.87	10.6	2.5e-26	-0.69	0.01	0.37	FALSE
16	NTR	Blood	NRBF2	0.03	0.01	bslmm	386	0.01	3.4e-05	0.21	-10.1	4.0e-24	0.34	0.20	0.04	FALSE
27	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	NRBF2	0.08	0.01	blup	40	0.03	6.6e-03	9.93	9.6	5.2e-22	-0.60	0.01	0.41	FALSE
2	GTEx	Adipose Subcutaneous	REEP3	0.10	0.03	lasso	3	0.03	7.2e-04	9.79	-9.5	2.1e-21	0.58	0.47	0.19	FALSE
7	GTEx	Esophagus Muscularis	NRBF2	0.10	0.03	enet	22	0.03	3.8e-03	-10.05	8.6	7.4e-18	-0.71	0.01	0.96	FALSE
14	GTEx	Testis	JMJD1C-AS1	0.22	0.08	enet	23	0.10	3.7e-05	7.22	7.5	7.4e-14	-0.42	0.67	0.04	FALSE
10	GTEx	Skin Sun Exposed Lower leg	NRBF2	0.06	0.01	lasso	3	0.00	4.0e-01	2.31	7.4	1.1e-13	-0.62	0.03	0.62	FALSE
19	YFS	Blood	NRBF2	0.33	0.12	enet	54	0.17	1.2e-53	0.21	6.7	2.6e-11	-0.40	1.00	0.00	FALSE
38	The Cancer Genome Atlas	Skin Cutaneous Melanoma	EGR2	0.12	0.10	blup	56	0.10	1.4e-03	-3.68	-6.5	6.7e-11	-0.03	0.02	0.29	FALSE
13	GTEx	Testis	ADO	0.21	0.23	lasso	7	0.22	6.6e-10	-6.51	6.3	2.1e-10	0.08	1.00	0.00	FALSE
8	GTEx	Muscle Skeletal	ADO	0.15	0.16	lasso	8	0.16	1.1e-15	-6.51	-6.3	3.0e-10	-0.08	1.00	0.00	FALSE