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chr10:97,895,300-100,145,129

Best TWAS P=1.23e-79 · Best GWAS P=6.5e-72 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
74	The Cancer Genome Atlas	Brain Lower Grade Glioma	FRAT2	0.02	0.00	blup	39	0.01	3.2e-02	-15.67	18.9	1.2e-79	-0.79	0.01	0.47	TRUE
18	GTEx	Breast Mammary Tissue (Female)	RRP12	0.24	0.07	lasso	5	0.02	1.1e-01	12.22	12.2	3.3e-34	-0.38	0.12	0.06	TRUE
91	The Cancer Genome Atlas	Thyroid Carcinoma	SLIT1	0.11	0.05	enet	17	0.09	2.6e-09	2.01	10.6	2.3e-26	-0.52	0.60	0.38	TRUE
31	GTEx	Nerve Tibial	PGAM1	0.16	0.06	enet	17	0.09	1.1e-06	-5.43	10.1	5.1e-24	-0.49	0.48	0.15	TRUE
85	The Cancer Genome Atlas	Prostate Adenocarcinoma	EXOSC1	0.07	0.04	lasso	2	0.02	1.5e-03	-4.41	5.6	1.9e-08	-0.36	0.05	0.37	TRUE
20	GTEx	Cells Transformed fibroblasts	FRAT1	0.08	0.04	lasso	3	0.05	2.3e-04	-17.91	18.0	1.2e-72	-0.99	0.01	0.98	FALSE
3	CommonMind	Brain Pre-frontal Cortex	FRAT2	0.05	0.04	lasso	2	0.04	2.3e-05	-15.67	17.9	1.4e-71	-0.90	0.02	0.98	FALSE
56	ROSMAP	Brain Pre-frontal Cortex	FRAT2	0.06	0.07	lasso	4	0.07	3.0e-09	-16.34	17.7	5.3e-70	-0.87	0.02	0.98	FALSE
34	GTEx	Skin Not Sun Exposed Suprapubic	ARHGAP19	0.14	0.06	lasso	4	0.05	8.9e-04	-17.91	17.6	4.6e-69	-0.98	0.01	0.99	FALSE
43	GTEx	Whole Blood	FRAT2	0.06	0.01	enet	7	0.01	8.8e-02	-16.90	17.5	8.1e-69	-0.70	0.21	0.48	FALSE
40	GTEx	Testis	FRAT2	0.19	0.10	lasso	3	0.13	1.7e-06	-15.77	17.3	7.3e-67	-0.89	0.13	0.86	FALSE
87	The Cancer Genome Atlas	Rectum Adenocarcinoma	RRP12	0.32	0.07	blup	56	0.11	1.9e-03	12.22	17.0	4.6e-65	-0.72	0.02	0.28	FALSE
64	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	RRP12	0.13	-0.01	blup	58	0.03	1.7e-02	12.22	17.0	9.0e-65	-0.68	0.04	0.38	FALSE
51	NTR	Blood	FRAT1	0.05	0.03	lasso	3	0.05	3.2e-16	11.92	16.5	1.6e-61	-0.58	1.00	0.00	FALSE
7	GTEx	Adipose Subcutaneous	ARHGAP19	0.08	0.08	lasso	3	0.07	1.3e-06	-16.94	16.4	1.2e-60	-0.90	0.23	0.73	FALSE
45	METSIM	Adipose	ARHGAP19	0.07	0.03	lasso	5	0.04	6.3e-07	-17.87	16.3	1.3e-59	-0.88	0.01	0.99	FALSE
21	GTEx	Esophagus Mucosa	FRAT2	0.09	0.07	lasso	5	0.09	1.4e-06	11.98	16.2	2.6e-59	-0.56	0.89	0.08	FALSE
27	GTEx	Lung	ARHGAP19	0.14	0.05	lasso	5	0.03	3.6e-03	-17.87	16.2	3.9e-59	-0.95	0.01	0.99	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ARHGAP19	0.07	0.05	lasso	5	0.04	3.2e-06	-16.94	16.1	4.2e-58	-0.92	0.63	0.25	FALSE
12	GTEx	Artery Tibial	ARHGAP19	0.09	0.06	lasso	4	0.05	9.3e-05	-16.94	15.9	4.9e-57	-0.92	0.04	0.95	FALSE
5	CommonMind	Brain Pre-frontal Cortex	RRP12	0.16	0.14	bslmm	506	0.17	1.2e-20	11.92	15.9	7.9e-57	-0.49	1.00	0.00	FALSE
72	The Cancer Genome Atlas	Brain Lower Grade Glioma	ARHGAP19	0.04	0.03	lasso	3	0.02	6.5e-03	-15.67	15.8	6.3e-56	-0.72	0.07	0.64	FALSE
54	ROSMAP	Brain Pre-frontal Cortex	RRP12	0.12	0.14	lasso	7	0.14	3.7e-18	11.98	15.6	8.4e-55	-0.49	1.00	0.00	FALSE
63	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLIT1	0.04	0.04	enet	15	0.04	1.1e-08	-16.83	-15.6	8.8e-55	0.75	0.73	0.27	FALSE
55	ROSMAP	Brain Pre-frontal Cortex	EXOSC1	0.04	0.01	enet	12	0.01	6.7e-03	-17.84	15.6	1.3e-54	-0.86	0.01	0.98	FALSE
37	GTEx	Skin Sun Exposed Lower leg	ARHGAP19	0.16	0.11	lasso	7	0.12	3.4e-10	-16.94	15.5	2.1e-54	-0.92	0.02	0.98	FALSE
70	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLIT1	0.12	0.12	lasso	1	0.11	1.6e-12	-15.51	-15.5	2.8e-54	0.78	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FRAT1	0.05	0.01	bslmm	469	0.02	4.9e-04	12.19	15.4	1.3e-53	-0.65	0.06	0.89	FALSE
77	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	RRP12	0.09	0.05	blup	57	0.05	1.6e-03	11.92	14.8	7.3e-50	-0.47	0.23	0.09	FALSE
57	ROSMAP	Brain Pre-frontal Cortex	HOGA1	0.06	0.01	bslmm	478	0.03	8.9e-05	-7.88	14.5	2.2e-47	-0.61	0.02	0.94	FALSE
75	The Cancer Genome Atlas	Brain Lower Grade Glioma	RRP12	0.02	0.01	blup	57	0.01	7.0e-02	11.90	14.4	4.5e-47	-0.41	0.12	0.05	FALSE
46	METSIM	Adipose	FRAT1	0.06	0.03	lasso	10	0.03	2.2e-05	12.22	14.0	8.0e-45	-0.50	0.99	0.01	FALSE
32	GTEx	Nerve Tibial	LCOR	0.12	0.06	lasso	1	0.03	3.0e-03	14.00	14.0	1.5e-44	-0.47	0.15	0.04	FALSE
23	GTEx	Heart Atrial Appendage	RP11-452K12.7	0.26	0.17	lasso	9	0.21	1.2e-09	11.90	13.9	3.2e-44	-0.39	1.00	0.00	FALSE
59	YFS	Blood	FRAT2	0.15	0.23	bslmm	466	0.23	4.2e-75	12.22	13.6	2.8e-42	-0.38	1.00	0.00	FALSE
42	GTEx	Whole Blood	RRP12	0.17	0.14	lasso	5	0.16	1.1e-14	12.22	13.5	2.1e-41	-0.34	1.00	0.00	FALSE
49	METSIM	Adipose	RRP12	0.13	0.09	lasso	8	0.10	3.6e-14	12.22	13.4	5.3e-41	-0.33	1.00	0.00	FALSE
50	METSIM	Adipose	UBTD1	0.06	0.01	enet	20	0.03	7.4e-05	-10.27	13.2	4.7e-40	-0.55	0.05	0.90	FALSE
52	NTR	Blood	FRAT2	0.06	0.07	bslmm	466	0.07	3.1e-20	11.98	13.2	1.0e-39	-0.37	1.00	0.00	FALSE
62	The Cancer Genome Atlas	Breast Invasive Carcinoma	RRP12	0.07	0.05	enet	19	0.05	8.6e-11	14.00	13.1	5.0e-39	-0.38	1.00	0.00	FALSE
69	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RRP12	0.05	0.05	lasso	6	0.05	1.6e-06	12.22	13.0	1.7e-38	-0.37	0.99	0.00	FALSE
22	GTEx	Heart Atrial Appendage	RRP12	0.26	0.24	enet	14	0.26	5.0e-12	11.98	12.8	1.2e-37	-0.32	1.00	0.00	FALSE
66	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FRAT1	0.06	0.01	blup	36	0.02	1.3e-03	5.70	12.8	1.5e-37	-0.69	0.02	0.74	FALSE
60	YFS	Blood	RRP12	0.28	0.46	lasso	2	0.46	1.1e-173	12.22	12.6	2.8e-36	-0.29	1.00	0.00	FALSE
67	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FRAT2	0.08	0.01	enet	14	0.03	1.1e-04	-17.87	12.5	8.0e-36	-0.64	0.01	0.95	FALSE
48	METSIM	Adipose	MMS19	0.08	0.02	blup	509	0.04	6.1e-07	-10.22	12.5	9.0e-36	-0.76	0.03	0.97	FALSE
9	GTEx	Artery Aorta	RRP12	0.16	0.11	lasso	6	0.09	9.1e-06	12.22	12.4	3.3e-35	-0.39	0.68	0.04	FALSE
10	GTEx	Artery Coronary	RRP12	0.23	0.02	enet	13	0.03	2.5e-02	13.96	12.3	8.8e-35	-0.48	0.06	0.48	FALSE
53	NTR	Blood	RRP12	0.14	0.22	lasso	5	0.21	2.7e-67	12.13	12.3	1.1e-34	-0.26	1.00	0.00	FALSE
47	METSIM	Adipose	FRAT2	0.04	0.06	lasso	6	0.04	3.8e-07	12.22	12.2	2.6e-34	-0.24	1.00	0.00	FALSE
28	GTEx	Muscle Skeletal	RRP12	0.26	0.27	lasso	4	0.27	1.5e-26	12.13	12.1	6.2e-34	-0.25	1.00	0.00	FALSE
65	The Cancer Genome Atlas	Colon Adenocarcinoma	RRP12	0.09	0.08	lasso	1	0.07	6.3e-05	12.11	12.1	9.6e-34	-0.24	0.68	0.04	FALSE
25	GTEx	Lung	RRP12	0.13	0.17	lasso	6	0.16	4.7e-12	11.98	12.1	1.8e-33	-0.25	1.00	0.00	FALSE
84	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	RRP12	0.14	0.15	lasso	1	0.12	1.6e-05	11.98	12.0	4.5e-33	-0.25	0.92	0.00	FALSE
30	GTEx	Muscle Skeletal	RP11-452K12.7	0.16	0.14	lasso	5	0.13	1.4e-12	11.98	12.0	4.9e-33	-0.25	1.00	0.00	FALSE
44	GTEx	Whole Blood	RP11-452K12.7	0.19	0.15	lasso	4	0.16	3.7e-14	11.98	11.9	6.8e-33	-0.27	1.00	0.00	FALSE
68	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RRP12	0.02	0.03	lasso	5	0.02	2.0e-03	11.88	11.9	1.2e-32	-0.25	0.13	0.07	FALSE
83	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RRP12	0.07	0.04	lasso	4	0.02	4.9e-02	11.90	11.9	1.2e-32	-0.26	0.06	0.04	FALSE
86	The Cancer Genome Atlas	Prostate Adenocarcinoma	RRP12	0.03	0.05	lasso	1	0.04	8.8e-05	11.90	11.9	1.2e-32	-0.26	0.67	0.08	FALSE
76	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	EXOSC1	0.22	0.02	enet	13	0.07	4.8e-04	10.59	11.9	1.4e-32	-0.51	0.01	0.56	FALSE
35	GTEx	Skin Sun Exposed Lower leg	RRP12	0.22	0.14	lasso	6	0.13	1.1e-10	11.92	11.9	1.8e-32	-0.25	1.00	0.00	FALSE
6	GTEx	Adipose Subcutaneous	RRP12	0.09	0.06	lasso	3	0.05	1.4e-04	11.90	11.7	7.8e-32	-0.26	0.83	0.01	FALSE
8	GTEx	Adipose Visceral Omentum	UBTD1	0.15	0.01	enet	21	0.04	2.3e-03	1.42	11.7	1.3e-31	-0.53	0.10	0.35	FALSE
24	GTEx	Heart Left Ventricle	RRP12	0.31	0.19	enet	15	0.20	5.1e-11	11.90	11.6	5.4e-31	-0.23	1.00	0.00	FALSE
17	GTEx	Brain Nucleus accumbens basal ganglia	RRP12	0.32	0.26	lasso	6	0.23	6.5e-07	11.98	11.4	3.4e-30	-0.21	0.76	0.02	FALSE
13	GTEx	Brain Caudate basal ganglia	RRP12	0.23	0.13	lasso	2	0.08	3.3e-03	11.03	11.4	5.9e-30	-0.25	0.27	0.08	FALSE
14	GTEx	Brain Cerebellar Hemisphere	RRP12	0.27	0.24	lasso	7	0.18	2.7e-05	11.90	11.2	2.9e-29	-0.23	0.48	0.12	FALSE
81	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ARHGAP19	0.12	0.00	blup	129	0.01	1.3e-01	-0.20	11.0	6.4e-28	-0.61	0.02	0.19	FALSE
16	GTEx	Brain Cortex	AVPI1	0.15	0.00	lasso	11	0.00	2.4e-01	-7.90	-10.5	1.3e-25	0.60	0.07	0.30	FALSE
71	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RRP12	0.14	0.07	lasso	4	0.10	3.3e-06	11.98	10.4	4.0e-25	-0.19	0.96	0.00	FALSE
79	The Cancer Genome Atlas	Lung Adenocarcinoma	MMS19	0.06	0.04	lasso	2	0.04	2.7e-05	-9.33	9.6	1.3e-21	-0.49	0.79	0.01	FALSE
33	GTEx	Pancreas	RRP12	0.22	0.21	enet	25	0.24	2.7e-10	11.88	9.4	3.7e-21	-0.19	0.99	0.00	FALSE
15	GTEx	Brain Cortex	RRP12	0.20	0.01	enet	17	0.03	5.7e-02	11.03	9.3	1.1e-20	-0.21	0.10	0.06	FALSE
38	GTEx	Spleen	RRP12	0.31	0.07	enet	11	0.14	2.6e-04	11.98	9.3	1.7e-20	-0.12	0.38	0.04	FALSE
80	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RRP12	0.07	0.02	blup	57	0.02	1.5e-03	14.58	8.9	7.1e-19	-0.17	0.09	0.03	FALSE
82	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	MMS19	0.38	0.01	blup	56	0.01	9.8e-02	-3.55	8.8	2.1e-18	-0.57	0.28	0.03	FALSE
90	The Cancer Genome Atlas	Thyroid Carcinoma	EXOSC1	0.08	0.01	blup	36	0.02	4.5e-03	-5.43	8.8	2.2e-18	-0.35	0.04	0.22	FALSE
11	GTEx	Artery Coronary	RP11-452K12.7	0.19	-0.01	lasso	5	0.03	3.4e-02	2.05	8.5	2.1e-17	-0.42	0.05	0.38	FALSE
36	GTEx	Skin Sun Exposed Lower leg	ZDHHC16	0.07	0.00	enet	26	0.01	2.0e-02	1.03	8.2	2.4e-16	-0.21	0.08	0.10	FALSE
89	The Cancer Genome Atlas	Thyroid Carcinoma	DHDPSL	0.26	0.15	lasso	3	0.15	2.8e-14	-7.88	7.9	2.4e-15	-0.33	0.00	1.00	FALSE
61	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FRAT2	0.05	0.01	blup	39	0.02	1.1e-02	12.11	7.9	2.8e-15	-0.04	0.03	0.03	FALSE
41	GTEx	Thyroid	HOGA1	0.26	0.37	lasso	1	0.37	7.4e-30	-7.88	7.9	3.3e-15	-0.33	1.00	0.00	FALSE
78	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SLIT1	0.19	0.03	blup	164	0.06	7.4e-04	2.12	-7.9	3.7e-15	0.44	0.09	0.17	FALSE
73	The Cancer Genome Atlas	Brain Lower Grade Glioma	EXOSC1	0.14	0.04	lasso	4	0.05	7.3e-07	-5.43	7.7	1.8e-14	-0.34	0.67	0.20	FALSE
58	YFS	Blood	EXOSC1	0.02	0.02	lasso	3	0.02	2.7e-06	6.24	6.5	8.3e-11	-0.05	0.98	0.00	FALSE
39	GTEx	Spleen	FRAT2	0.23	0.02	lasso	6	-0.01	4.8e-01	12.22	6.3	2.4e-10	0.01	0.12	0.07	FALSE
4	CommonMind	Brain Pre-frontal Cortex	HOGA1	0.25	0.16	bslmm	505	0.23	3.0e-27	-7.88	6.3	2.5e-10	-0.24	1.00	0.00	FALSE
19	GTEx	Cells EBV-transformed lymphocytes	MORN4	0.30	0.08	lasso	13	0.08	1.3e-03	-0.33	6.2	5.7e-10	-0.40	0.31	0.31	FALSE
88	The Cancer Genome Atlas	Stomach Adenocarcinoma	ANKRD2	0.04	0.02	blup	49	0.02	1.2e-02	-4.78	-6.1	8.7e-10	0.19	0.04	0.39	FALSE
29	GTEx	Muscle Skeletal	EXOSC1	0.06	0.00	lasso	4	0.02	1.1e-02	6.40	6.0	1.9e-09	0.00	0.12	0.03	FALSE
26	GTEx	Lung	PGAM1	0.14	0.04	lasso	6	0.04	2.8e-04	-4.41	5.3	1.2e-07	-0.40	0.41	0.06	FALSE