TWAS hub - PHRF1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.345	0.0850	1.7e-04	-0.008	NA	0.064	NA	0.003	6.8e-01	NA	5.8e-03	NA	2.6e-01
2	GTEx	Esophagus Mucosa	0.160	0.0550	2.2e-04	0.061	NA	0.069	NA	0.105	6.3e-05	NA	2.3e-05	NA	1.7e-07
3	GTEx	Skin Sun Exposed Lower leg	0.093	0.0340	4.7e-03	0.001	NA	0.029	NA	0.012	2.5e-01	NA	1.7e-03	NA	2.9e-02
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.045	0.0199	2.7e-05	0.052	0.038	0.032	NA	0.037	1.6e-06	4e-05	1.6e-04	NA	4.5e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Lupus	10.9	16.5	25.9	0.3	4.8	5.1	4.1
Hypothyroidism (self reported)	7.1	16.4	28.9	-1.4	5.1	2.9	5.4
Hypothyroidism/myxoedema (self-reported)	5.0	9.8	19.2	-1.3	4.4	1.4	4.0
Hayfever/allergic rhinitis (self-reported)	3.4	4.5	6.9	2.2	-2.2	-1.3	-2.6
Reason for reducing amount of alcohol drunk: Health precaution	3.2	3.8	5.8	-1.4	1.5	2.4	2.3
HbA1C	3.0	3.4	7.1	-2.7	0.7	1.2	2.1
Ever unenthusiastic/disinterested for a whole week	3.0	3.7	6.7	-1.4	1.8	1.7	2.6
Medication: Ibuprofen (e.g. Nurofen)	3.0	3.9	7.0	-1.3	2.6	2.3	1.2
Lung cancer (father)	3.0	3.5	9.6	-0.2	-3.1	-0.5	-2.0
Blood Platelet Count	2.9	33.4	127.7	-1.6	0.5	-11.3	1.8
Neuroticism (2016)	2.7	3.9	7.7	0.6	-1.9	-1.9	-2.8
Medication: Levothyroxine sodium	2.7	4.6	10.5	-1.2	3.2	0.8	2.4
Mouth/teeth dental problems: Loose teeth	2.7	3.3	6.8	-2.2	-1.0	-2.6	-0.6
Number of self-reported non-cancer illnesses	2.7	4.7	8.7	2.3	-1.7	-1.3	-3.0
Osteoporosis (self-reported)	2.6	3.2	11.5	-0.5	0.6	3.4	0.9
Allergy or Eczema	2.5	6.5	11.6	2.3	-2.8	-1.3	-3.4
Ever depressed for a whole week	2.5	3.1	5.7	-0.3	1.8	1.8	2.4
Commuting to job workplace: Car/motor vehicle	2.4	2.8	6.6	0.0	-2.1	-2.6	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.3	2.6	7.2	2.7	0.7	1.6	-0.5
Fasting Glucose	2.2	2.6	5.5	0.5	0.1	2.4	2.2
Hayfever, allergic rhinitis or eczema	2.2	4.8	10.2	2.2	-2.0	-0.5	-3.2
Medication: Paracetamol	2.2	3.7	5.4	1.3	-2.3	-1.6	-2.2
Eye problems/disorders: None of the above	2.2	2.6	5.4	1.6	-1.5	-0.4	-2.3
Hand grip strength (right)	2.1	5.6	9.8	-0.9	2.2	3.1	2.7
Townsend deprivation index at recruitment	2.1	2.9	4.2	1.9	-2.0	-0.9	-1.7
Maternal smoking around birth	2.1	3.1	5.8	1.9	-1.5	-0.9	-2.4
Chronic bronchitis/emphysema (father)	2.1	2.4	4.3	-1.0	2.1	1.3	1.7
Medication: Ibuprofen	2.1	2.5	5.0	-0.8	2.2	1.9	0.8
Body Mass Index (BMI) (2010)	2.0	2.8	8.1	-0.6	1.6	2.9	0.0
Respiratory disease	2.0	4.5	6.2	2.0	-1.9	-2.1	-2.5
Age started oral contraceptive pill	2.0	2.5	5.3	0.1	-1.3	-1.7	-2.3
Alzheimer’s Disease (in mother)	1.9	2.3	5.6	0.7	1.3	2.4	1.1
Primary Biliary Cirrhosis	1.9	2.7	5.1	-0.6	2.3	0.3	2.3
Hand grip strength (left)	1.8	4.7	10.9	-0.5	1.3	3.3	2.4
Relative age voice broke	1.7	2.7	3.7	0.7	-1.7	-1.9	-1.9
Supplements: Glucosamine	1.7	2.2	4.2	-1.5	2.1	1.2	0.9
Asthma	1.7	3.3	5.3	2.3	-1.8	-0.4	-2.1
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	2.7	-1.6	1.2	0.8	1.6
Breast Cancer	1.6	3.8	12.6	0.2	-0.8	3.5	1.5
Triglycerides	1.6	2.6	5.0	-0.7	2.2	2.2	0.0
Sitting height	1.6	11.2	17.1	-1.2	4.1	3.4	3.8
Allergy	1.6	3.8	9.0	-1.8	1.7	0.2	3.0
Gout (self-reported)	1.6	2.2	3.4	0.9	-1.4	-1.5	-1.9
Medication for hormone replacement therapy	1.5	1.7	2.2	1.5	-1.1	-1.4	-1.2
Medication: Atenolol	1.5	1.8	2.4	-1.2	1.2	1.4	1.5
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.4	9.7	1.6	1.0	3.1	0.7
Mother’s age at death	1.5	1.8	4.5	-2.1	-0.3	-1.6	-0.1
Qualifications: O levels/GCSEs or equivalent	1.4	2.3	6.5	2.6	-0.2	-0.2	-1.6
Neck or shoulder pain in last month	1.4	2.0	3.1	-0.2	-1.8	-1.7	-1.5
Asthma (self-reported)	1.4	2.7	3.6	1.9	-1.8	-0.5	-1.9
Heart attack/myocardial infarction (self-reported)	1.4	1.8	3.8	-1.4	0.7	1.0	1.9
Waist Hip Ratio (WHR)	1.3	6.0	11.5	0.8	2.4	3.4	2.5
Heart attack	1.3	1.6	3.5	-1.3	0.6	1.0	1.9
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	3.6	1.1	-0.5	-1.1	-1.9
Loud music exposure frequency	1.3	1.4	2.9	0.4	0.7	1.5	1.7
Number of full brothers	1.3	1.7	3.8	1.6	-0.4	2.0	-0.3
Emphysema/chronic bronchitis	1.3	1.5	1.9	1.1	-1.1	-1.3	-1.4
Chest pain or discomfort	1.3	1.8	6.0	1.0	-0.1	2.5	0.5
Pain type(s) experienced in last month: Hip pain	1.3	1.7	3.8	0.3	-1.5	-0.7	-1.9
Average weekly beer plus cider intake	1.3	1.9	2.9	1.7	-1.4	-1.0	-1.3
HDL Cholesterol	1.2	2.1	6.0	-0.2	-1.5	-2.5	0.0
Ulcerative Colitis	1.2	1.7	4.0	0.2	-2.0	-1.5	-0.9
Ever used hormone-replacement therapy (HRT)	1.2	1.5	4.4	2.1	-0.1	-0.4	-1.2
Diabetes (father)	1.2	1.5	4.1	-2.0	1.1	-0.3	0.7
Alcohol usually taken with meals	1.2	2.0	5.2	-2.3	1.1	1.0	0.6
Forced vital capacity (FVC)	1.2	4.5	8.0	-1.0	2.8	2.5	1.7
Fluid intelligence score	1.2	2.4	3.8	1.0	1.9	1.1	1.9
Length of working week for main job	1.2	1.3	2.9	-0.3	1.7	1.0	1.1
Shortness of breath walking on level ground	1.2	1.4	4.7	2.2	0.4	0.7	-0.5
Rheumatoid Arthritis	1.1	1.5	2.3	-1.0	1.1	1.5	1.3
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	3.9	-0.6	-0.7	-2.0	-0.4
Angina	1.1	1.5	4.3	0.2	0.7	1.0	2.1
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.6	6.4	1.3	1.3	2.5	0.7
Qualifications: CSEs or equivalent	1.1	1.4	3.0	0.1	0.6	1.5	1.7
Had menopause	1.1	1.3	2.1	0.5	-1.5	-1.2	-1.2
Illnesses of siblings	1.1	1.5	5.6	0.1	-0.5	-2.4	-0.5
Hair/balding pattern: Pattern 3	1.1	1.7	4.0	-0.4	-0.1	-2.0	-1.6
Birth weight of first child	1.1	1.9	4.8	0.3	1.5	2.2	0.7
Peak expiratory flow (PEF)	1.1	2.6	4.8	-2.2	1.9	1.1	0.9
Eye problems/disorders: Cataract	1.1	1.3	2.2	-1.5	0.5	1.1	1.2
Wears glasses or contact lenses	1.1	1.3	4.2	-0.9	2.0	-0.4	0.4
Medication: Paracetamol	1.1	1.7	2.6	1.2	-1.6	-0.7	-1.5
Alcohol drinker status: Previous	1.1	1.2	2.3	0.6	-1.5	-0.8	-1.2
Prostate Cancer	1.0	1.4	4.0	0.0	-0.5	-2.0	-1.1
Blood White Count	1.0	7.7	27.7	-0.4	1.0	5.3	1.3
Medication: Co-codamol	1.0	1.2	3.3	1.8	-0.9	0.0	-0.8
Current tobacco smoking	1.0	1.6	3.3	1.0	-1.8	-1.2	-0.8
Multivitamins +/- minerals	1.0	1.3	4.8	0.2	0.6	2.2	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.2	2.9	-0.9	1.7	0.5	1.0
Angina (self-reported)	1.0	1.4	3.3	0.7	0.8	1.1	1.8
Medication: Allopurinol	1.0	1.4	3.3	-0.7	-0.9	-1.8	-1.0
Back pain experienced in last month	1.0	1.4	2.5	1.2	-1.3	-0.3	-1.6
Medication: Blood pressure	1.0	1.9	2.7	1.5	-1.5	1.6	-0.5
Commuting to job workplace: Cycle	1.0	1.2	2.4	-0.7	1.6	-1.1	0.8
Cholesterol lowering medication	1.0	1.5	3.0	0.8	0.3	1.7	1.5
Relative age of first facial hair	0.9	1.8	3.4	-1.8	1.0	-1.6	0.5
Mouth/teeth dental problems	0.9	1.3	4.9	2.2	0.2	0.4	-0.5
Father’s age at death	0.9	1.2	2.6	0.4	-0.4	-1.6	-1.3
Happiness	0.9	1.0	3.5	0.6	-0.5	1.9	-0.0
Blood clot in the leg (DVT)	0.9	1.2	2.8	-1.7	-0.3	1.0	1.0
Medication for pain relief, constipation, heartburn	0.9	1.5	2.7	-1.6	1.2	0.5	1.3
Migraine (self-reported)	0.9	1.1	1.6	-1.3	0.9	1.0	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	3.0	-0.2	-1.7	-1.0	0.4
Number of full sisters	0.9	1.1	2.1	1.3	-1.4	0.2	-0.6
Illnesses of father: Heart disease	0.9	1.2	3.5	-0.2	-1.9	-1.1	-0.5
Illnesses of siblings: Diabetes	0.9	1.1	3.9	-0.2	0.4	2.0	0.7
Arm fat percentage (left)	0.9	3.6	5.5	2.1	-2.3	1.4	-1.5
Mineral and other dietary supplements	0.9	1.3	3.7	0.7	-0.5	-1.9	-0.8
Breast cancer (self-reported)	0.9	1.1	1.8	-1.1	0.5	-1.3	1.0
Schizophrenia (2018)	0.8	1.7	6.3	2.5	0.3	0.6	-0.1
Alzheimer’s Disease (including proxy)	0.8	1.2	3.2	1.2	0.1	1.8	0.3
Ever had hysterectomy (womb removed)	0.8	0.9	3.2	-0.1	0.2	0.7	-1.8
Vitamin and mineral supplements	0.8	1.1	3.2	0.4	-1.0	-1.8	-0.5
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.9	1.4	0.9	0.0	-0.9
High blood pressure (mother)	0.8	1.1	2.1	1.5	-0.6	-1.2	-0.7
Hair/balding pattern: Pattern 2	0.8	1.0	2.5	-0.3	-0.2	1.1	1.6
Exposure to tobacco smoke at home	0.8	0.9	2.1	1.0	-0.0	1.4	0.5
Wheeze or whistling in the chest in last year	0.8	1.5	3.3	1.8	-0.5	1.6	0.0
Average weekly champagne plus white wine intake	0.8	1.0	2.7	-0.1	1.0	-1.6	0.7
Medication: Lisinopril	0.8	1.0	1.8	1.3	-1.3	0.7	-0.4
Heart disease (siblings)	0.8	0.9	3.2	-0.5	-0.2	1.8	-0.4
Intelligence (Savage-Jansen 2018)	0.7	2.2	5.0	1.1	2.2	0.6	1.5
Hearing difficulty/problems: Yes	0.7	1.1	2.5	-0.5	1.6	0.8	1.1
Age when periods started (menarche)	0.7	1.6	4.2	-2.0	-0.9	-1.1	-0.3
Body mass index (BMI)	0.7	2.9	5.6	1.7	-1.8	2.4	-0.1
Waist circumference	0.7	2.6	4.6	2.0	-1.3	2.1	-0.2
Had other major operations	0.7	0.8	1.5	0.5	1.2	1.1	0.5
Time employed in main current job	0.7	0.9	1.4	-0.9	1.2	1.0	-0.3
Number of live births	0.7	1.0	2.1	-1.0	-1.4	-0.7	-0.5
Forced expiratory volume in 1-second (FEV1)	0.7	2.2	4.1	-1.5	2.0	1.3	1.0
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.8	0.5	-0.6	1.3	-1.1
High blood pressure (siblings)	0.7	1.0	3.2	0.2	0.6	1.8	0.6
Body fat percentage	0.7	2.7	4.3	2.1	-1.6	1.8	-1.0
Smoking status: Previous	0.7	1.0	2.4	-1.6	-1.0	0.0	0.7
Loneliness, isolation	0.7	1.0	3.4	-0.2	0.7	-1.9	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	2.3	-0.5	0.6	1.5	0.7
Smoking status: Current	0.7	1.1	2.1	1.0	-1.4	-0.9	-0.7
Leg fat percentage (left)	0.7	2.7	4.1	2.0	-1.8	1.8	-0.6
Arm fat-free mass (left)	0.7	3.4	9.3	0.4	0.3	3.0	2.0
Fractured/broken bones in last 5 years	0.7	0.8	1.8	-1.3	-0.3	1.2	0.0
Diastolic blood pressure, automated reading	0.7	2.1	3.3	0.7	-1.3	1.8	-1.7
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	3.5	1.9	0.2	-0.1	0.2
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.1	-1.4	-0.4	0.9	0.7
Leg fat mass (left)	0.7	2.7	5.2	1.8	-1.6	2.3	-0.1
Arm predicted mass (left)	0.7	3.3	9.6	0.3	0.4	3.1	1.9
Alzheimer’s Disease (in father)	0.6	0.7	1.4	1.0	-0.6	0.1	-1.2
Verbal and Numeric Reasoning (VNR)	0.6	1.4	2.8	0.8	1.7	0.2	1.4
Mean Putamen Volume	0.6	0.7	2.0	1.4	-0.3	-0.4	-0.6
Schizophrenia (2014)	0.6	1.4	4.9	2.2	0.1	-0.5	-0.5
Smoking Status	0.6	1.6	5.9	0.5	-2.4	-0.1	-0.1
Chronotype (morning person)	0.6	1.4	2.3	0.1	1.5	1.5	1.0
Diabetes (mother)	0.6	0.7	2.7	1.6	0.1	-0.3	0.3
Trunk fat percentage	0.6	2.4	4.3	2.1	-1.2	1.8	-0.8
Serious illness, injury or assault to yourself	0.6	0.8	1.3	-0.3	1.0	1.1	0.9
Qualifications: None of the above	0.6	1.2	2.1	-0.8	-0.3	1.4	1.4
Diabetes (self-reported)	0.6	1.0	2.1	1.0	-0.7	-1.4	-0.4
Arm fat percentage (right)	0.6	2.5	3.6	1.7	-1.7	1.9	-0.8
Hip circumference	0.6	2.5	3.9	1.6	-2.0	1.6	-1.0
Falls in the last year	0.6	0.8	2.1	1.5	-0.0	0.7	-0.9
Noisy workplace	0.6	0.8	1.4	-1.2	-0.5	-0.9	-0.8
Mouth/teeth dental problems: Dentures	0.6	1.0	2.8	-1.7	-0.7	0.4	0.7
Impedance of arm (left)	0.6	2.6	5.6	-0.5	0.6	-2.4	-2.1
Arm fat mass (right)	0.6	2.6	6.2	1.4	-1.4	2.5	-0.1
Pulse wave reflection index	0.6	0.7	2.4	1.6	0.6	-0.1	-0.2
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	3.0	-1.7	0.0	-0.1	-0.3
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.3	1.5	-0.6	-0.0	-0.4
Leg fat percentage (right)	0.6	2.4	3.8	1.8	-1.9	1.3	-0.8
Medication: Seretide 50 evohaler	0.6	0.6	1.6	1.3	0.9	-0.4	0.1
Mean time to correctly identify matches	0.6	1.2	1.7	-1.0	-0.6	-1.3	-1.3
Whole body fat mass	0.6	2.4	5.6	1.6	-1.3	2.4	-0.3
Leg fat mass (right)	0.6	2.4	4.8	1.6	-1.5	2.2	0.0
Commuting to job workplace: Walk	0.6	0.6	1.5	0.1	0.8	0.6	1.2
Illnesses of father: None of the above (group 1)	0.6	0.7	1.9	0.7	-0.7	-0.1	-1.4
Arm fat mass (left)	0.6	2.3	4.4	1.6	-1.5	2.1	-0.3
Financial situation satisfaction	0.6	0.7	1.3	-1.1	0.9	-0.5	0.8
Myopia	0.6	0.9	3.0	0.1	1.7	0.8	0.2
Vascular/heart problems diagnosed by doctor	0.6	1.5	4.6	-0.9	2.1	-0.5	0.7
Schizophrenia vs Biploar Disorder	0.5	0.7	2.0	1.4	-0.7	0.6	0.0
Ulcerative Colitis (UC)	0.5	1.0	2.1	-1.5	-1.0	-0.6	-0.6
BMI	0.5	3.0	8.4	1.2	-1.0	2.9	1.2
Type 2 Diabetes (T2D) (2018)	0.5	1.0	1.3	0.9	-1.0	-1.2	-0.9
Neuroticism	0.5	1.1	3.1	1.8	0.0	-0.8	-0.8
Frequency of depressed mood in last 2 weeks	0.5	0.8	1.4	-0.0	1.2	-0.7	-1.1
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.8	1.4	-0.0	-0.8	-0.4
Trunk fat mass	0.5	2.2	4.8	1.6	-1.0	2.2	-0.2
Past tobacco smoking	0.5	1.0	2.0	1.4	1.2	0.0	-0.7
Pain all over the body in last month	0.5	0.5	1.2	1.1	-0.5	0.7	-0.3
Weight	0.5	2.6	8.1	1.2	-0.7	2.8	0.7
Alcohol intake versus 10 years previously	0.5	0.7	1.4	1.2	-1.0	0.6	-0.5
Medication: Lansoprazole	0.5	0.6	1.2	0.4	0.0	1.0	1.1
Prospective memory result	0.5	0.7	1.3	-0.1	-1.1	-0.9	-0.7
Illnesses of mother	0.5	0.6	1.7	-1.3	-0.1	0.5	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.4	-1.2	1.1	0.7	0.3
Glaucoma (self-reported)	0.5	0.6	1.5	0.7	0.3	-1.2	0.5
Forced vital capacity (FVC), Best measure	0.5	1.7	3.7	-0.3	1.9	1.6	0.4
Arm fat-free mass (right)	0.5	2.5	7.4	0.3	0.1	2.7	1.5
Number of children fathered	0.5	0.6	1.5	-1.2	0.4	0.6	0.7
Pulse wave peak to peak time	0.5	0.6	1.7	-1.3	0.1	-0.3	0.7
Health satisfaction	0.5	0.7	1.9	1.4	-0.1	0.2	-0.8
Arm predicted mass (right)	0.5	2.6	7.6	0.3	0.2	2.8	1.6
Overall health rating	0.5	1.1	1.5	0.8	-1.2	0.7	-1.2
Family relationship satisfaction	0.5	0.6	1.3	-0.0	-1.1	-0.8	-0.5
Medication: Aspirin	0.5	0.7	1.0	0.9	0.7	0.7	1.0
Knee pain experienced in last month	0.5	0.7	2.7	0.4	-1.6	0.3	-0.2
Long-standing illness, disability or infirmity	0.5	0.8	1.5	1.2	-1.1	0.7	-0.3
Friendships satisfaction	0.5	0.6	2.1	-0.1	0.5	0.5	1.4
Medication for cholesterol	0.5	0.7	1.9	-1.4	0.6	-0.7	0.2
Medication: Aspirin	0.5	0.7	1.7	1.3	0.7	0.1	0.7
Ever taken oral contraceptive pill	0.5	0.5	1.2	-0.2	1.1	-0.9	-0.3
Medication: Atorvastatin	0.5	0.6	1.4	-0.2	0.1	1.2	1.0
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.2	-1.1	0.7	-0.6	0.4
Crohns Disease (2017)	0.4	0.8	1.0	-0.6	0.8	1.0	1.0
Crohns Disease (2012)	0.4	0.7	2.0	-1.4	0.3	0.4	0.7
Systolic Blood Pressure	0.4	2.1	6.2	0.4	-2.5	-0.1	-1.4
Cardiovascular Disease	0.4	1.3	2.1	1.4	-1.1	1.2	-0.6
Lung FEV1/FVC ratio	0.4	2.1	4.1	-1.3	-2.0	-1.5	-0.5
Lung FVC	0.4	2.2	5.8	-0.6	2.4	1.4	0.8
Number of treatments/medications taken	0.4	0.8	2.0	0.6	0.7	1.4	0.4
Supplements: Zinc	0.4	0.4	1.0	1.0	-0.2	0.2	-0.8
Medication: Metformin	0.4	0.5	1.0	0.5	-1.0	-0.9	-0.2
High blood pressure	0.4	1.1	3.0	0.9	-1.7	0.3	-0.8
Financial difficulties in last 2 years	0.4	0.6	1.1	0.8	-1.0	-0.7	-0.4
Trunk fat-free mass	0.4	2.3	5.0	-0.1	0.8	2.2	1.9
Pulse rate	0.4	0.6	1.4	0.3	-1.2	0.7	-0.7
Qualifications: A levels/AS levels or equivalent	0.4	0.9	3.1	0.2	0.5	1.8	-0.3
Medication: Cholesterol lowering	0.4	0.6	1.9	0.5	-1.4	-0.4	-0.3
Depression (self-reported)	0.4	0.4	1.5	-1.2	0.2	0.2	0.3
Pulse wave Arterial Stiffness index	0.4	0.5	1.5	1.2	0.4	0.5	-0.3
Trunk predicted mass	0.4	2.5	5.2	-0.3	0.8	2.3	2.0
Standing height	0.4	3.5	7.0	-1.0	2.6	1.4	2.0
Tense / ‘highly strung’	0.4	0.6	1.1	0.6	-1.1	-0.4	-0.9
Hair/balding pattern: Pattern 4	0.4	0.9	2.2	0.0	0.6	1.0	1.5
Headache pain in last month	0.4	0.8	2.4	0.3	1.6	0.6	0.5
Medication: Amlodipine	0.4	0.6	1.7	0.7	0.2	1.3	0.4
Exposure to tobacco smoke outside home	0.4	0.6	1.2	0.1	-1.1	1.0	-0.2
Comparative body size at age 10	0.4	1.0	3.5	0.4	0.2	1.9	0.7
Age at first live birth	0.4	0.8	1.1	-0.9	1.0	-1.1	0.3
Qualifications: College or University degree	0.4	1.3	3.6	-0.9	1.9	-0.8	0.2
Medication: Omeprazole	0.4	0.5	1.9	1.4	0.1	0.3	0.3
Pulse rate, automated reading	0.4	1.1	1.7	1.3	-1.2	1.1	-0.0
Comparative height size at age 10	0.4	2.3	5.0	0.9	2.2	1.6	1.0
Suffer from ‘nerves’	0.4	0.6	1.4	0.6	0.5	1.2	0.7
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.2	0.3	0.8	1.1	-0.2
Whole body fat-free mass	0.4	2.3	6.2	0.1	0.5	2.5	1.6
Leg fat-free mass (right)	0.4	2.3	7.8	0.5	0.2	2.8	1.1
Osteoarthritis (self-reported)	0.4	0.5	1.4	0.6	-1.2	-0.4	-0.3
Whole body water mass	0.4	2.2	6.1	0.2	0.5	2.5	1.6
Leg predicted mass (right)	0.4	2.4	7.9	0.5	0.2	2.8	1.1
Eye problems/disorders: Glaucoma	0.4	0.5	1.4	0.8	-0.1	-1.2	0.1
High cholesterol (Self-reported)	0.4	0.8	1.2	0.8	-0.7	1.1	0.8
Medication: Bendroflumethiazide	0.4	0.5	1.0	0.5	0.1	1.0	1.0
Ever smoked	0.4	0.7	2.0	-0.7	-1.4	-0.5	-0.2
Basal metabolic rate	0.4	2.4	7.2	0.6	0.2	2.7	1.4
Depression (Nagel 2018)	0.3	0.4	1.3	0.6	1.1	0.1	0.1
Worry (Nagel 2018)	0.3	0.6	1.6	1.3	0.1	-0.7	-0.4
Reaction Time	0.3	0.5	0.6	-0.7	-0.8	-0.6	-0.8
Height	0.3	6.6	13.8	-0.8	3.7	2.4	2.5
Average weekly spirits intake	0.3	0.4	1.0	0.6	-0.0	1.0	0.3
Pack years adult smoking proportion	0.3	0.4	0.7	-0.8	-0.4	-0.9	-0.0
Impedance of leg (right)	0.3	1.4	3.6	-0.7	1.2	-1.9	0.1
Leg fat-free mass (left)	0.3	1.9	6.1	0.5	-0.0	2.5	1.0
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.8	-0.1	0.6	0.9	-0.3
Stomach or abdominal pain in last month	0.3	0.4	0.9	0.9	-0.5	-0.1	-0.6
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.8	0.4	0.9	0.2	-0.8
Leg predicted mass (left)	0.3	1.8	5.7	0.5	-0.0	2.4	1.0
Number of incorrect matches in round	0.3	0.4	1.3	0.5	1.2	0.4	-0.1
Medication: Simvastatin	0.3	0.4	1.4	1.2	0.0	0.3	0.4
Impedance of arm (right)	0.3	1.6	3.2	-0.5	1.1	-1.8	-1.2
Worrier / anxious feelings	0.3	0.6	1.0	-1.0	0.1	-0.8	-0.7
Breastfed as a baby	0.3	0.4	1.0	0.5	1.0	0.5	0.2
Worry too long after embarrassment	0.3	0.5	1.0	0.3	0.6	1.0	0.8
Alcohol intake frequency.	0.3	0.7	1.2	0.5	-0.9	-0.8	-1.1
Leg pain on walking	0.3	0.4	0.9	0.9	-0.7	0.1	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.7	0.8	-0.2	0.2	-0.8
Supplements: Vitamin C	0.3	0.3	1.0	-0.1	-0.5	-1.0	-0.0
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.0	-0.7	0.3	0.1	-1.0
Ever had bowel cancer screening	0.3	0.3	0.8	-0.4	0.5	0.9	0.3
Diabetes diagnosed by doctor	0.3	0.6	1.4	1.2	-0.6	-0.6	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.9	-1.0	-0.4	-0.9	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.6	0.9	1.3	0.0	-0.2
Commuting to job workplace: Public transport	0.3	0.4	0.7	0.8	0.2	-0.6	-0.8
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.6	0.2	-0.7	0.7	-0.8
Illnesses of father: High blood pressure	0.3	0.3	0.8	0.6	-0.3	0.4	-0.9
Alcohol drinker status: Never	0.3	0.4	1.5	0.2	1.2	-0.2	-0.2
Irritability	0.3	0.4	0.6	0.7	-0.8	-0.3	-0.7
Pain experienced in last month	0.3	0.6	1.4	0.0	1.2	0.1	0.9
Supplements: Calcium	0.3	0.3	0.5	-0.1	0.6	0.7	-0.5
Impedance of whole body	0.3	1.3	2.8	-0.5	1.1	-1.7	-1.0
Bipolar Disorder (2018)	0.2	0.3	0.7	-0.8	0.4	-0.6	-0.3
Bipolar Disorder or Schizophrenia	0.2	0.6	1.9	1.4	0.4	0.3	-0.3
Depressed Affect (Nagel 2018)	0.2	0.4	1.1	0.1	0.6	-1.1	-0.1
Neuroticism (Nagel 2018)	0.2	0.5	1.1	0.8	0.2	-1.1	-0.2
Irritable Bowel Disease (IBD)	0.2	0.5	1.9	-1.4	-0.0	0.1	0.4
Ovarian Cancer	0.2	0.3	0.5	-0.1	0.4	0.6	-0.7
Age at First Birth	0.2	0.2	0.9	0.2	0.1	-0.9	0.0
LDL Cholesterol	0.2	0.4	0.8	0.8	0.2	0.9	0.0
Blood Red Count	0.2	2.4	6.1	-1.4	0.3	2.5	1.1
Sensitivity / hurt feelings	0.2	0.3	0.5	-0.6	0.2	0.5	0.7
Systolic blood pressure, automated reading	0.2	0.6	1.0	-1.0	-0.6	0.4	-0.8
Average weekly fortified wine intake	0.2	0.2	0.4	0.6	-0.1	-0.3	-0.6
Taking other prescription medications	0.2	0.3	0.9	0.9	0.5	0.4	-0.0
Impedance of leg (left)	0.2	0.9	1.9	-0.4	1.2	-1.4	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.4	-0.6	1.2	0.8	-0.2
Had major operations	0.2	0.3	0.4	-0.6	-0.7	-0.1	-0.6
Age at last live birth	0.2	0.3	0.8	-0.9	0.5	-0.4	-0.0
Hypertension (Self-reported)	0.2	0.7	1.4	0.7	-1.2	0.1	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	0.6	0.7	0.7	0.5	0.8
Average weekly red wine intake	0.2	0.4	0.7	-0.5	0.0	-0.7	-0.8
Medication: Gliclazide	0.2	0.2	0.6	0.5	-0.8	0.0	-0.1
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.3	0.6	-0.5	0.5	0.2
Number of operations (self-reported)	0.2	0.3	0.6	-0.8	0.3	0.4	-0.5
Unable to work because of sickness or disability	0.2	0.2	0.5	0.4	-0.5	-0.0	0.7
Blood Eosinophil Count	0.1	0.4	0.9	0.1	0.9	0.9	0.2
Heel T-Score	0.1	1.1	1.7	-1.2	-0.5	1.3	1.0
Severe depression (siblings)	0.1	0.1	0.4	0.1	-0.3	-0.2	-0.6
Fed-up feelings	0.1	0.3	0.5	0.4	-0.6	0.2	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.4	0.4	-0.1	0.6	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.3	0.5	0.1	-0.4	-0.4
Medication: Ramipril	0.1	0.2	0.5	-0.0	0.0	-0.7	-0.3
Neuroticism score	0.1	0.1	0.3	0.5	0.5	-0.1	0.0
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.6	0.1	-0.1	-0.2	-0.8
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.5	-0.2	-0.7	-0.2	-0.0
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.5	-0.2	0.7	0.5	0.2
Birth weight	0.1	0.2	0.3	-0.2	0.5	0.6	0.5
Heart disease (mother)	0.1	0.1	0.4	0.1	-0.0	-0.1	-0.6
Mood swings	0.1	0.1	0.3	0.1	-0.1	-0.5	-0.5
Qualifications: nursing, teaching	0.1	0.1	0.3	-0.1	-0.2	-0.4	-0.5
Miserableness	0.1	0.1	0.4	-0.1	0.6	0.5	0.0
Guilty feelings	0.1	0.2	0.4	-0.4	-0.3	-0.1	0.6
Hearing aid user	0.1	0.1	0.3	0.0	0.2	-0.5	-0.3
Risk taking	0.1	0.2	0.5	0.3	-0.5	-0.7	-0.2
Basal cell carcinoma (self-reported)	0.1	0.2	0.5	-0.2	0.4	0.7	-0.2
Pack years of smoking	0.1	0.2	0.6	-0.8	0.0	-0.4	0.3
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.4	0.8	0.8	0.2	-0.5	0.9
Tanning	0.0	0.4	0.7	-0.8	0.5	0.8	-0.3
Nervous feelings	0.0	0.1	0.2	0.1	-0.2	-0.0	-0.4
Hearing difficulty/problems with background noise	0.0	0.1	0.1	0.3	0.3	0.2	-0.0
Medication: Blood pressure	0.0	0.1	0.2	0.2	-0.0	-0.3	0.4

Hub : Genes

PHRF1

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Trait associations