Hub : Genes

PHRF1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.345	0.0850	1.7e-04	-0.008	NA	0.064	NA	0.003	6.8e-01	NA	5.8e-03	NA	2.6e-01
2	GTEx	Esophagus Mucosa	0.160	0.0550	2.2e-04	0.061	NA	0.069	NA	0.105	6.3e-05	NA	2.3e-05	NA	1.7e-07
3	GTEx	Skin Sun Exposed Lower leg	0.093	0.0340	4.7e-03	0.001	NA	0.029	NA	0.012	2.5e-01	NA	1.7e-03	NA	2.9e-02
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.045	0.0199	2.7e-05	0.052	0.038	0.032	NA	0.037	1.6e-06	4e-05	1.6e-04	NA	4.5e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.2	0.3	0.7	-0.8	0.4	-0.6	-0.3
Bipolar Disorder or Schizophrenia	0.2	0.6	1.9	1.4	0.4	0.3	-0.3
Depressed Affect (Nagel 2018)	0.2	0.4	1.1	0.1	0.6	-1.1	-0.1
Depression (Nagel 2018)	0.3	0.4	1.3	0.6	1.1	0.1	0.1
Intelligence (Savage-Jansen 2018)	0.7	2.2	5.0	1.1	2.2	0.6	1.5
Neuroticism (Nagel 2018)	0.2	0.5	1.1	0.8	0.2	-1.1	-0.2
Schizophrenia (2018)	0.8	1.7	6.3	2.5	0.3	0.6	-0.1
Schizophrenia vs Biploar Disorder	0.5	0.7	2.0	1.4	-0.7	0.6	0.0
Worry (Nagel 2018)	0.3	0.6	1.6	1.3	0.1	-0.7	-0.4
Alzheimer’s Disease (in mother)	1.9	2.3	5.6	0.7	1.3	2.4	1.1
Alzheimer’s Disease (in father)	0.6	0.7	1.4	1.0	-0.6	0.1	-1.2
Alzheimer’s Disease (including proxy)	0.8	1.2	3.2	1.2	0.1	1.8	0.3
Crohns Disease (2017)	0.4	0.8	1.0	-0.6	0.8	1.0	1.0
Irritable Bowel Disease (IBD)	0.2	0.5	1.9	-1.4	-0.0	0.1	0.4
Ulcerative Colitis (UC)	0.5	1.0	2.1	-1.5	-1.0	-0.6	-0.6
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.3	0.5	0.6	-0.7	-0.8	-0.6	-0.8
Verbal and Numeric Reasoning (VNR)	0.6	1.4	2.8	0.8	1.7	0.2	1.4
Breast Cancer	1.6	3.8	12.6	0.2	-0.8	3.5	1.5
Ovarian Cancer	0.2	0.3	0.5	-0.1	0.4	0.6	-0.7
Prostate Cancer	1.0	1.4	4.0	0.0	-0.5	-2.0	-1.1
Age at First Birth	0.2	0.2	0.9	0.2	0.1	-0.9	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	2.0	2.8	8.1	-0.6	1.6	2.9	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.4	0.7	2.0	-1.4	0.3	0.4	0.7
Mean Putamen Volume	0.6	0.7	2.0	1.4	-0.3	-0.4	-0.6
Fasting Glucose	2.2	2.6	5.5	0.5	0.1	2.4	2.2
HbA1C	3.0	3.4	7.1	-2.7	0.7	1.2	2.1
HDL Cholesterol	1.2	2.1	6.0	-0.2	-1.5	-2.5	0.0
LDL Cholesterol	0.2	0.4	0.8	0.8	0.2	0.9	0.0
Lupus	10.9	16.5	25.9	0.3	4.8	5.1	4.1
Neuroticism (2016)	2.7	3.9	7.7	0.6	-1.9	-1.9	-2.8
Primary Biliary Cirrhosis	1.9	2.7	5.1	-0.6	2.3	0.3	2.3
Rheumatoid Arthritis	1.1	1.5	2.3	-1.0	1.1	1.5	1.3
Schizophrenia (2014)	0.6	1.4	4.9	2.2	0.1	-0.5	-0.5
Triglycerides	1.6	2.6	5.0	-0.7	2.2	2.2	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	1.2	1.7	4.0	0.2	-2.0	-1.5	-0.9
Blood Eosinophil Count	0.1	0.4	0.9	0.1	0.9	0.9	0.2
Blood Platelet Count	2.9	33.4	127.7	-1.6	0.5	-11.3	1.8
Blood Red Count	0.2	2.4	6.1	-1.4	0.3	2.5	1.1
Blood White Count	1.0	7.7	27.7	-0.4	1.0	5.3	1.3
Heel T-Score	0.1	1.1	1.7	-1.2	-0.5	1.3	1.0
BMI	0.5	3.0	8.4	1.2	-1.0	2.9	1.2
Height	0.3	6.6	13.8	-0.8	3.7	2.4	2.5
Waist Hip Ratio (WHR)	1.3	6.0	11.5	0.8	2.4	3.4	2.5
Systolic Blood Pressure	0.4	2.1	6.2	0.4	-2.5	-0.1	-1.4
Smoking Status	0.6	1.6	5.9	0.5	-2.4	-0.1	-0.1
Allergy or Eczema	2.5	6.5	11.6	2.3	-2.8	-1.3	-3.4
Cardiovascular Disease	0.4	1.3	2.1	1.4	-1.1	1.2	-0.6
Hypothyroidism (self reported)	7.1	16.4	28.9	-1.4	5.1	2.9	5.4
Respiratory disease	2.0	4.5	6.2	2.0	-1.9	-2.1	-2.5
Type 2 Diabetes (T2D) (2018)	0.5	1.0	1.3	0.9	-1.0	-1.2	-0.9
Lung FEV1/FVC ratio	0.4	2.1	4.1	-1.3	-2.0	-1.5	-0.5
Lung FVC	0.4	2.2	5.8	-0.6	2.4	1.4	0.8
Neuroticism	0.5	1.1	3.1	1.8	0.0	-0.8	-0.8
Chronotype (morning person)	0.6	1.4	2.3	0.1	1.5	1.5	1.0
Hair Pigment	0.0	0.4	0.8	0.8	0.2	-0.5	0.9
Tanning	0.0	0.4	0.7	-0.8	0.5	0.8	-0.3
Hand grip strength (left)	1.8	4.7	10.9	-0.5	1.3	3.3	2.4
Number of treatments/medications taken	0.4	0.8	2.0	0.6	0.7	1.4	0.4
Average weekly spirits intake	0.3	0.4	1.0	0.6	-0.0	1.0	0.3
Sensitivity / hurt feelings	0.2	0.3	0.5	-0.6	0.2	0.5	0.7
Frequency of depressed mood in last 2 weeks	0.5	0.8	1.4	-0.0	1.2	-0.7	-1.1
Hearing difficulty/problems: Yes	0.7	1.1	2.5	-0.5	1.6	0.8	1.1
Relative age of first facial hair	0.9	1.8	3.4	-1.8	1.0	-1.6	0.5
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.8	1.4	-0.0	-0.8	-0.4
Ever used hormone-replacement therapy (HRT)	1.2	1.5	4.4	2.1	-0.1	-0.4	-1.2
Ever had hysterectomy (womb removed)	0.8	0.9	3.2	-0.1	0.2	0.7	-1.8
Systolic blood pressure, automated reading	0.2	0.6	1.0	-1.0	-0.6	0.4	-0.8
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	3.9	-0.6	-0.7	-2.0	-0.4
Angina	1.1	1.5	4.3	0.2	0.7	1.0	2.1
Medication for hormone replacement therapy	1.5	1.7	2.2	1.5	-1.1	-1.4	-1.2
Vitamin and mineral supplements	0.8	1.1	3.2	0.4	-1.0	-1.8	-0.5
Supplements: Zinc	0.4	0.4	1.0	1.0	-0.2	0.2	-0.8
Medication: Co-codamol	1.0	1.2	3.3	1.8	-0.9	0.0	-0.8
Medication: Metformin	0.4	0.5	1.0	0.5	-1.0	-0.9	-0.2
Diabetes (father)	1.2	1.5	4.1	-2.0	1.1	-0.3	0.7
Diabetes (mother)	0.6	0.7	2.7	1.6	0.1	-0.3	0.3
Severe depression (siblings)	0.1	0.1	0.4	0.1	-0.3	-0.2	-0.6
Pack years adult smoking proportion	0.3	0.4	0.7	-0.8	-0.4	-0.9	-0.0
Impedance of leg (right)	0.3	1.4	3.6	-0.7	1.2	-1.9	0.1
Leg fat-free mass (left)	0.3	1.9	6.1	0.5	-0.0	2.5	1.0
Trunk fat percentage	0.6	2.4	4.3	2.1	-1.2	1.8	-0.8
Hand grip strength (right)	2.1	5.6	9.8	-0.9	2.2	3.1	2.7
Townsend deprivation index at recruitment	2.1	2.9	4.2	1.9	-2.0	-0.9	-1.7
Current tobacco smoking	1.0	1.6	3.3	1.0	-1.8	-1.2	-0.8
Average weekly fortified wine intake	0.2	0.2	0.4	0.6	-0.1	-0.3	-0.6
Maternal smoking around birth	2.1	3.1	5.8	1.9	-1.5	-0.9	-2.4
Fed-up feelings	0.1	0.3	0.5	0.4	-0.6	0.2	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.4	0.4	-0.1	0.6	-0.1
Relative age voice broke	1.7	2.7	3.7	0.7	-1.7	-1.9	-1.9
Taking other prescription medications	0.2	0.3	0.9	0.9	0.5	0.4	-0.0
Age when periods started (menarche)	0.7	1.6	4.2	-2.0	-0.9	-1.1	-0.3
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.8	-0.1	0.6	0.9	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.6	6.4	1.3	1.3	2.5	0.7
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.9	1.4	0.9	0.0	-0.9
Qualifications: CSEs or equivalent	1.1	1.4	3.0	0.1	0.6	1.5	1.7
Serious illness, injury or assault to yourself	0.6	0.8	1.3	-0.3	1.0	1.1	0.9
High blood pressure	0.4	1.1	3.0	0.9	-1.7	0.3	-0.8
Hayfever, allergic rhinitis or eczema	2.2	4.8	10.2	2.2	-2.0	-0.5	-3.2
Multivitamins +/- minerals	1.0	1.3	4.8	0.2	0.6	2.2	0.2
Stomach or abdominal pain in last month	0.3	0.4	0.9	0.9	-0.5	-0.1	-0.6
Supplements: Glucosamine	1.7	2.2	4.2	-1.5	2.1	1.2	0.9
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.8	0.4	0.9	0.2	-0.8
Medication: Atenolol	1.5	1.8	2.4	-1.2	1.2	1.4	1.5
Medication: Levothyroxine sodium	2.7	4.6	10.5	-1.2	3.2	0.8	2.4
Sitting height	1.6	11.2	17.1	-1.2	4.1	3.4	3.8
Chronic bronchitis/emphysema (father)	2.1	2.4	4.3	-1.0	2.1	1.3	1.7
High blood pressure (mother)	0.8	1.1	2.1	1.5	-0.6	-1.2	-0.7
Body mass index (BMI)	0.7	2.9	5.6	1.7	-1.8	2.4	-0.1
Impedance of leg (left)	0.2	0.9	1.9	-0.4	1.2	-1.4	0.1
Leg predicted mass (left)	0.3	1.8	5.7	0.5	-0.0	2.4	1.0
Trunk fat mass	0.5	2.2	4.8	1.6	-1.0	2.2	-0.2
Waist circumference	0.7	2.6	4.6	2.0	-1.3	2.1	-0.2
Number of incorrect matches in round	0.3	0.4	1.3	0.5	1.2	0.4	-0.1
Past tobacco smoking	0.5	1.0	2.0	1.4	1.2	0.0	-0.7
Alcohol usually taken with meals	1.2	2.0	5.2	-2.3	1.1	1.0	0.6
Nervous feelings	0.0	0.1	0.2	0.1	-0.2	-0.0	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.3	0.5	0.1	-0.4	-0.4
Hearing difficulty/problems with background noise	0.0	0.1	0.1	0.3	0.3	0.2	-0.0
Hair/balding pattern: Pattern 2	0.8	1.0	2.5	-0.3	-0.2	1.1	1.6
Had menopause	1.1	1.3	2.1	0.5	-1.5	-1.2	-1.2
Had other major operations	0.7	0.8	1.5	0.5	1.2	1.1	0.5
Forced vital capacity (FVC)	1.2	4.5	8.0	-1.0	2.8	2.5	1.7
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.4	9.7	1.6	1.0	3.1	0.7
Ever unenthusiastic/disinterested for a whole week	3.0	3.7	6.7	-1.4	1.8	1.7	2.6
Qualifications: None of the above	0.6	1.2	2.1	-0.8	-0.3	1.4	1.4
Financial difficulties in last 2 years	0.4	0.6	1.1	0.8	-1.0	-0.7	-0.4
Mouth/teeth dental problems	0.9	1.3	4.9	2.2	0.2	0.4	-0.5
Heart attack	1.3	1.6	3.5	-1.3	0.6	1.0	1.9
Allergy	1.6	3.8	9.0	-1.8	1.7	0.2	3.0
Pain all over the body in last month	0.5	0.5	1.2	1.1	-0.5	0.7	-0.3
Diabetes (self-reported)	0.6	1.0	2.1	1.0	-0.7	-1.4	-0.4
Hayfever/allergic rhinitis (self-reported)	3.4	4.5	6.9	2.2	-2.2	-1.3	-2.6
Medication: Ramipril	0.1	0.2	0.5	-0.0	0.0	-0.7	-0.3
Medication: Simvastatin	0.3	0.4	1.4	1.2	0.0	0.3	0.4
Fluid intelligence score	1.2	2.4	3.8	1.0	1.9	1.1	1.9
Illnesses of siblings	1.1	1.5	5.6	0.1	-0.5	-2.4	-0.5
Neuroticism score	0.1	0.1	0.3	0.5	0.5	-0.1	0.0
Weight	0.5	2.6	8.1	1.2	-0.7	2.8	0.7
Impedance of arm (right)	0.3	1.6	3.2	-0.5	1.1	-1.8	-1.2
Arm fat percentage (right)	0.6	2.5	3.6	1.7	-1.7	1.9	-0.8
Trunk fat-free mass	0.4	2.3	5.0	-0.1	0.8	2.2	1.9
Hip circumference	0.6	2.5	3.9	1.6	-2.0	1.6	-1.0
Time employed in main current job	0.7	0.9	1.4	-0.9	1.2	1.0	-0.3
Alcohol intake versus 10 years previously	0.5	0.7	1.4	1.2	-1.0	0.6	-0.5
Father’s age at death	0.9	1.2	2.6	0.4	-0.4	-1.6	-1.3
Worrier / anxious feelings	0.3	0.6	1.0	-1.0	0.1	-0.8	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.6	0.1	-0.1	-0.2	-0.8
Falls in the last year	0.6	0.8	2.1	1.5	-0.0	0.7	-0.9
Hair/balding pattern: Pattern 3	1.1	1.7	4.0	-0.4	-0.1	-2.0	-1.6
Number of live births	0.7	1.0	2.1	-1.0	-1.4	-0.7	-0.5
Forced expiratory volume in 1-second (FEV1)	0.7	2.2	4.1	-1.5	2.0	1.3	1.0
Pulse rate	0.4	0.6	1.4	0.3	-1.2	0.7	-0.7
Happiness	0.9	1.0	3.5	0.6	-0.5	1.9	-0.0
Noisy workplace	0.6	0.8	1.4	-1.2	-0.5	-0.9	-0.8
Qualifications: A levels/AS levels or equivalent	0.4	0.9	3.1	0.2	0.5	1.8	-0.3
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	3.6	1.1	-0.5	-1.1	-1.9
Mouth/teeth dental problems: Dentures	0.6	1.0	2.8	-1.7	-0.7	0.4	0.7
Asthma	1.7	3.3	5.3	2.3	-1.8	-0.4	-2.1
Medication: Ibuprofen (e.g. Nurofen)	3.0	3.9	7.0	-1.3	2.6	2.3	1.2
Medication: Cholesterol lowering	0.4	0.6	1.9	0.5	-1.4	-0.4	-0.3
Depression (self-reported)	0.4	0.4	1.5	-1.2	0.2	0.2	0.3
Medication: Lansoprazole	0.5	0.6	1.2	0.4	0.0	1.0	1.1
Prospective memory result	0.5	0.7	1.3	-0.1	-1.1	-0.9	-0.7
Lung cancer (father)	3.0	3.5	9.6	-0.2	-3.1	-0.5	-2.0
Illnesses of mother	0.5	0.6	1.7	-1.3	-0.1	0.5	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.4	-0.6	1.2	0.8	-0.2
Pulse wave Arterial Stiffness index	0.4	0.5	1.5	1.2	0.4	0.5	-0.3
Impedance of arm (left)	0.6	2.6	5.6	-0.5	0.6	-2.4	-2.1
Arm fat mass (right)	0.6	2.6	6.2	1.4	-1.4	2.5	-0.1
Trunk predicted mass	0.4	2.5	5.2	-0.3	0.8	2.3	2.0
Standing height	0.4	3.5	7.0	-1.0	2.6	1.4	2.0
Length of working week for main job	1.2	1.3	2.9	-0.3	1.7	1.0	1.1
Exposure to tobacco smoke at home	0.8	0.9	2.1	1.0	-0.0	1.4	0.5
Breastfed as a baby	0.3	0.4	1.0	0.5	1.0	0.5	0.2
Tense / ‘highly strung’	0.4	0.6	1.1	0.6	-1.1	-0.4	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.4	-1.2	1.1	0.7	0.3
Hair/balding pattern: Pattern 4	0.4	0.9	2.2	0.0	0.6	1.0	1.5
Birth weight of first child	1.1	1.9	4.8	0.3	1.5	2.2	0.7
Peak expiratory flow (PEF)	1.1	2.6	4.8	-2.2	1.9	1.1	0.9
Pulse wave reflection index	0.6	0.7	2.4	1.6	0.6	-0.1	-0.2
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.5	-0.2	-0.7	-0.2	-0.0
Loud music exposure frequency	1.3	1.4	2.9	0.4	0.7	1.5	1.7
Qualifications: O levels/GCSEs or equivalent	1.4	2.3	6.5	2.6	-0.2	-0.2	-1.6
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	3.0	-1.7	0.0	-0.1	-0.3
Blood clot in the leg (DVT)	0.9	1.2	2.8	-1.7	-0.3	1.0	1.0
Medication: Paracetamol	2.2	3.7	5.4	1.3	-2.3	-1.6	-2.2
Headache pain in last month	0.4	0.8	2.4	0.3	1.6	0.6	0.5
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.5	-0.2	0.7	0.5	0.2
Glaucoma (self-reported)	0.5	0.6	1.5	0.7	0.3	-1.2	0.5
Gout (self-reported)	1.6	2.2	3.4	0.9	-1.4	-1.5	-1.9
Hypothyroidism/myxoedema (self-reported)	5.0	9.8	19.2	-1.3	4.4	1.4	4.0
Medication: Amlodipine	0.4	0.6	1.7	0.7	0.2	1.3	0.4
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.8	0.5	-0.6	1.3	-1.1
Birth weight	0.1	0.2	0.3	-0.2	0.5	0.6	0.5
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.3	1.5	-0.6	-0.0	-0.4
High blood pressure (siblings)	0.7	1.0	3.2	0.2	0.6	1.8	0.6
Forced vital capacity (FVC), Best measure	0.5	1.7	3.7	-0.3	1.9	1.6	0.4
Body fat percentage	0.7	2.7	4.3	2.1	-1.6	1.8	-1.0
Leg fat percentage (right)	0.6	2.4	3.8	1.8	-1.9	1.3	-0.8
Arm fat-free mass (right)	0.5	2.5	7.4	0.3	0.1	2.7	1.5
Exposure to tobacco smoke outside home	0.4	0.6	1.2	0.1	-1.1	1.0	-0.2
Comparative body size at age 10	0.4	1.0	3.5	0.4	0.2	1.9	0.7
Number of full brothers	1.3	1.7	3.8	1.6	-0.4	2.0	-0.3
Worry too long after embarrassment	0.3	0.5	1.0	0.3	0.6	1.0	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.2	2.9	-0.9	1.7	0.5	1.0
Wheeze or whistling in the chest in last year	0.8	1.5	3.3	1.8	-0.5	1.6	0.0
Number of children fathered	0.5	0.6	1.5	-1.2	0.4	0.6	0.7
Reason for reducing amount of alcohol drunk: Health precaution	3.2	3.8	5.8	-1.4	1.5	2.4	2.3
Age at first live birth	0.4	0.8	1.1	-0.9	1.0	-1.1	0.3
Pulse wave peak to peak time	0.5	0.6	1.7	-1.3	0.1	-0.3	0.7
Health satisfaction	0.5	0.7	1.9	1.4	-0.1	0.2	-0.8
Shortness of breath walking on level ground	1.2	1.4	4.7	2.2	0.4	0.7	-0.5
Qualifications: College or University degree	0.4	1.3	3.6	-0.9	1.9	-0.8	0.2
Eye problems/disorders: None of the above	2.2	2.6	5.4	1.6	-1.5	-0.4	-2.3
Mouth/teeth dental problems: Loose teeth	2.7	3.3	6.8	-2.2	-1.0	-2.6	-0.6
Emphysema/chronic bronchitis	1.3	1.5	1.9	1.1	-1.1	-1.3	-1.4
Medication for pain relief, constipation, heartburn	0.9	1.5	2.7	-1.6	1.2	0.5	1.3
Neck or shoulder pain in last month	1.4	2.0	3.1	-0.2	-1.8	-1.7	-1.5
Medication: Blood pressure	0.0	0.1	0.2	0.2	-0.0	-0.3	0.4
Angina (self-reported)	1.0	1.4	3.3	0.7	0.8	1.1	1.8
Migraine (self-reported)	0.9	1.1	1.6	-1.3	0.9	1.0	1.1
Medication: Ibuprofen	2.1	2.5	5.0	-0.8	2.2	1.9	0.8
Medication: Allopurinol	1.0	1.4	3.3	-0.7	-0.9	-1.8	-1.0
Medication: Omeprazole	0.4	0.5	1.9	1.4	0.1	0.3	0.3
Medication: Seretide 50 evohaler	0.6	0.6	1.6	1.3	0.9	-0.4	0.1
Mean time to correctly identify matches	0.6	1.2	1.7	-1.0	-0.6	-1.3	-1.3
Heart disease (mother)	0.1	0.1	0.4	0.1	-0.0	-0.1	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	3.0	-0.2	-1.7	-1.0	0.4
Whole body fat mass	0.6	2.4	5.6	1.6	-1.3	2.4	-0.3
Leg fat mass (right)	0.6	2.4	4.8	1.6	-1.5	2.2	0.0
Arm predicted mass (right)	0.5	2.6	7.6	0.3	0.2	2.8	1.6
Pulse rate, automated reading	0.4	1.1	1.7	1.3	-1.2	1.1	-0.0
Alcohol intake frequency.	0.3	0.7	1.2	0.5	-0.9	-0.8	-1.1
Comparative height size at age 10	0.4	2.3	5.0	0.9	2.2	1.6	1.0
Number of full sisters	0.9	1.1	2.1	1.3	-1.4	0.2	-0.6
Suffer from ‘nerves’	0.4	0.6	1.4	0.6	0.5	1.2	0.7
Overall health rating	0.5	1.1	1.5	0.8	-1.2	0.7	-1.2
Chest pain or discomfort	1.3	1.8	6.0	1.0	-0.1	2.5	0.5
Had major operations	0.2	0.3	0.4	-0.6	-0.7	-0.1	-0.6
Age at last live birth	0.2	0.3	0.8	-0.9	0.5	-0.4	-0.0
Family relationship satisfaction	0.5	0.6	1.3	-0.0	-1.1	-0.8	-0.5
Leg pain on walking	0.3	0.4	0.9	0.9	-0.7	0.1	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.7	0.8	-0.2	0.2	-0.8
Commuting to job workplace: Car/motor vehicle	2.4	2.8	6.6	0.0	-2.1	-2.6	-0.4
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.2	0.3	0.8	1.1	-0.2
Medication: Aspirin	0.5	0.7	1.0	0.9	0.7	0.7	1.0
Supplements: Vitamin C	0.3	0.3	1.0	-0.1	-0.5	-1.0	-0.0
Knee pain experienced in last month	0.5	0.7	2.7	0.4	-1.6	0.3	-0.2
Hypertension (Self-reported)	0.2	0.7	1.4	0.7	-1.2	0.1	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.3	2.6	7.2	2.7	0.7	1.6	-0.5
Illnesses of father: Heart disease	0.9	1.2	3.5	-0.2	-1.9	-1.1	-0.5
Illnesses of siblings: Diabetes	0.9	1.1	3.9	-0.2	0.4	2.0	0.7
Smoking status: Previous	0.7	1.0	2.4	-1.6	-1.0	0.0	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	0.6	0.7	0.7	0.5	0.8
Whole body fat-free mass	0.4	2.3	6.2	0.1	0.5	2.5	1.6
Leg fat-free mass (right)	0.4	2.3	7.8	0.5	0.2	2.8	1.1
Arm fat percentage (left)	0.9	3.6	5.5	2.1	-2.3	1.4	-1.5
Average weekly red wine intake	0.2	0.4	0.7	-0.5	0.0	-0.7	-0.8
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.0	-0.7	0.3	0.1	-1.0
Mood swings	0.1	0.1	0.3	0.1	-0.1	-0.5	-0.5
Loneliness, isolation	0.7	1.0	3.4	-0.2	0.7	-1.9	0.1
Long-standing illness, disability or infirmity	0.5	0.8	1.5	1.2	-1.1	0.7	-0.3
Ever had bowel cancer screening	0.3	0.3	0.8	-0.4	0.5	0.9	0.3
Diabetes diagnosed by doctor	0.3	0.6	1.4	1.2	-0.6	-0.6	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	2.7	-1.6	1.2	0.8	1.6
Friendships satisfaction	0.5	0.6	2.1	-0.1	0.5	0.5	1.4
Qualifications: nursing, teaching	0.1	0.1	0.3	-0.1	-0.2	-0.4	-0.5
Commuting to job workplace: Walk	0.6	0.6	1.5	0.1	0.8	0.6	1.2
Eye problems/disorders: Cataract	1.1	1.3	2.2	-1.5	0.5	1.1	1.2
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.9	-1.0	-0.4	-0.9	-0.1
Medication for cholesterol	0.5	0.7	1.9	-1.4	0.6	-0.7	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	2.3	-0.5	0.6	1.5	0.7
Back pain experienced in last month	1.0	1.4	2.5	1.2	-1.3	-0.3	-1.6
Mineral and other dietary supplements	0.9	1.3	3.7	0.7	-0.5	-1.9	-0.8
Breast cancer (self-reported)	0.9	1.1	1.8	-1.1	0.5	-1.3	1.0
Asthma (self-reported)	1.4	2.7	3.6	1.9	-1.8	-0.5	-1.9
Osteoporosis (self-reported)	2.6	3.2	11.5	-0.5	0.6	3.4	0.9
Osteoarthritis (self-reported)	0.4	0.5	1.4	0.6	-1.2	-0.4	-0.3
Medication: Aspirin	0.5	0.7	1.7	1.3	0.7	0.1	0.7
Medication: Gliclazide	0.2	0.2	0.6	0.5	-0.8	0.0	-0.1
Illnesses of father: None of the above (group 1)	0.6	0.7	1.9	0.7	-0.7	-0.1	-1.4
Smoking status: Current	0.7	1.1	2.1	1.0	-1.4	-0.9	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.6	0.9	1.3	0.0	-0.2
Whole body water mass	0.4	2.2	6.1	0.2	0.5	2.5	1.6
Leg predicted mass (right)	0.4	2.4	7.9	0.5	0.2	2.8	1.1
Arm fat mass (left)	0.6	2.3	4.4	1.6	-1.5	2.1	-0.3
Number of self-reported non-cancer illnesses	2.7	4.7	8.7	2.3	-1.7	-1.3	-3.0
Average weekly champagne plus white wine intake	0.8	1.0	2.7	-0.1	1.0	-1.6	0.7
Miserableness	0.1	0.1	0.4	-0.1	0.6	0.5	0.0
Guilty feelings	0.1	0.2	0.4	-0.4	-0.3	-0.1	0.6
Wears glasses or contact lenses	1.1	1.3	4.2	-0.9	2.0	-0.4	0.4
Ever taken oral contraceptive pill	0.5	0.5	1.2	-0.2	1.1	-0.9	-0.3
Hearing aid user	0.1	0.1	0.3	0.0	0.2	-0.5	-0.3
Mother’s age at death	1.5	1.8	4.5	-2.1	-0.3	-1.6	-0.1
Financial situation satisfaction	0.6	0.7	1.3	-1.1	0.9	-0.5	0.8
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.3	0.6	-0.5	0.5	0.2
Commuting to job workplace: Public transport	0.3	0.4	0.7	0.8	0.2	-0.6	-0.8
Eye problems/disorders: Glaucoma	0.4	0.5	1.4	0.8	-0.1	-1.2	0.1
Medication: Blood pressure	1.0	1.9	2.7	1.5	-1.5	1.6	-0.5
Pain type(s) experienced in last month: Hip pain	1.3	1.7	3.8	0.3	-1.5	-0.7	-1.9
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.6	0.2	-0.7	0.7	-0.8
High cholesterol (Self-reported)	0.4	0.8	1.2	0.8	-0.7	1.1	0.8
Medication: Bendroflumethiazide	0.4	0.5	1.0	0.5	0.1	1.0	1.0
Medication: Paracetamol	1.1	1.7	2.6	1.2	-1.6	-0.7	-1.5
Medication: Lisinopril	0.8	1.0	1.8	1.3	-1.3	0.7	-0.4
Medication: Atorvastatin	0.5	0.6	1.4	-0.2	0.1	1.2	1.0
Illnesses of father: High blood pressure	0.3	0.3	0.8	0.6	-0.3	0.4	-0.9
Alcohol drinker status: Never	0.3	0.4	1.5	0.2	1.2	-0.2	-0.2
Ever smoked	0.4	0.7	2.0	-0.7	-1.4	-0.5	-0.2
Basal metabolic rate	0.4	2.4	7.2	0.6	0.2	2.7	1.4
Leg fat percentage (left)	0.7	2.7	4.1	2.0	-1.8	1.8	-0.6
Arm fat-free mass (left)	0.7	3.4	9.3	0.4	0.3	3.0	2.0
Number of operations (self-reported)	0.2	0.3	0.6	-0.8	0.3	0.4	-0.5
Average weekly beer plus cider intake	1.3	1.9	2.9	1.7	-1.4	-1.0	-1.3
Irritability	0.3	0.4	0.6	0.7	-0.8	-0.3	-0.7
Risk taking	0.1	0.2	0.5	0.3	-0.5	-0.7	-0.2
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.2	-1.1	0.7	-0.6	0.4
Fractured/broken bones in last 5 years	0.7	0.8	1.8	-1.3	-0.3	1.2	0.0
Age started oral contraceptive pill	2.0	2.5	5.3	0.1	-1.3	-1.7	-2.3
Diastolic blood pressure, automated reading	0.7	2.1	3.3	0.7	-1.3	1.8	-1.7
Ever depressed for a whole week	2.5	3.1	5.7	-0.3	1.8	1.8	2.4
Unable to work because of sickness or disability	0.2	0.2	0.5	0.4	-0.5	-0.0	0.7
Commuting to job workplace: Cycle	1.0	1.2	2.4	-0.7	1.6	-1.1	0.8
Myopia	0.6	0.9	3.0	0.1	1.7	0.8	0.2
Vascular/heart problems diagnosed by doctor	0.6	1.5	4.6	-0.9	2.1	-0.5	0.7
Cholesterol lowering medication	1.0	1.5	3.0	0.8	0.3	1.7	1.5
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	3.5	1.9	0.2	-0.1	0.2
Pain experienced in last month	0.3	0.6	1.4	0.0	1.2	0.1	0.9
Supplements: Calcium	0.3	0.3	0.5	-0.1	0.6	0.7	-0.5
Basal cell carcinoma (self-reported)	0.1	0.2	0.5	-0.2	0.4	0.7	-0.2
Heart attack/myocardial infarction (self-reported)	1.4	1.8	3.8	-1.4	0.7	1.0	1.9
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.1	-1.4	-0.4	0.9	0.7
Heart disease (siblings)	0.8	0.9	3.2	-0.5	-0.2	1.8	-0.4
Alcohol drinker status: Previous	1.1	1.2	2.3	0.6	-1.5	-0.8	-1.2
Pack years of smoking	0.1	0.2	0.6	-0.8	0.0	-0.4	0.3
Impedance of whole body	0.3	1.3	2.8	-0.5	1.1	-1.7	-1.0
Leg fat mass (left)	0.7	2.7	5.2	1.8	-1.6	2.3	-0.1
Arm predicted mass (left)	0.7	3.3	9.6	0.3	0.4	3.1	1.9