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chr11:16,532,857-18,822,037

Best TWAS P=2.93e-10 · Best GWAS P=1.89e-08 conditioned to 0.0203

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
27	METSIM	Adipose	SAAL1	0.07	0.03	enet	28	0.06	8.2e-09	5.3	-6.3	2.9e-10	0.62	0.10	0.90	TRUE
25	GTEx	Thyroid	NUCB2	0.07	0.02	lasso	4	0.02	1.3e-02	-3.7	-5.8	6.7e-09	-0.02	0.05	0.45	TRUE
16	GTEx	Heart Left Ventricle	SAAL1	0.20	0.09	lasso	8	0.08	5.3e-05	5.4	-5.8	7.2e-09	0.50	0.06	0.93	FALSE
11	GTEx	Cells Transformed fibroblasts	SAAL1	0.22	0.19	enet	18	0.23	4.5e-17	5.3	-5.8	7.4e-09	0.50	0.07	0.93	FALSE
38	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SAAL1	0.02	0.01	blup	52	0.01	3.7e-02	5.4	-5.8	9.0e-09	0.51	0.01	0.79	FALSE
24	GTEx	Stomach	SAAL1	0.17	0.06	lasso	5	0.10	1.3e-05	5.5	-5.7	1.1e-08	0.46	0.06	0.88	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	SAAL1	0.12	0.24	enet	13	0.24	1.0e-26	5.3	-5.7	1.3e-08	0.55	0.02	0.98	FALSE
40	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SAAL1	0.07	0.03	blup	52	0.05	5.1e-03	5.4	-5.6	1.7e-08	0.44	0.01	0.76	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	SAAL1	0.39	0.34	lasso	7	0.33	1.2e-11	5.3	-5.6	1.9e-08	0.49	0.06	0.94	FALSE
4	GTEx	Adipose Visceral Omentum	SAAL1	0.21	0.05	enet	27	0.06	7.8e-04	5.1	-5.6	2.5e-08	0.49	0.08	0.87	FALSE
29	The Cancer Genome Atlas	Breast Invasive Carcinoma	SAAL1	0.02	0.03	lasso	2	0.03	3.3e-07	5.5	-5.6	2.5e-08	0.48	0.01	0.99	FALSE
2	GTEx	Adipose Subcutaneous	SERGEF	0.19	0.17	lasso	8	0.19	9.4e-16	5.0	5.5	3.1e-08	-0.67	0.30	0.70	FALSE
35	The Cancer Genome Atlas	Lung Adenocarcinoma	SAAL1	0.05	0.07	lasso	4	0.07	4.0e-08	5.3	-5.5	3.4e-08	0.46	0.01	0.99	FALSE
28	YFS	Blood	SAAL1	0.14	0.15	bslmm	443	0.15	5.2e-46	5.3	-5.5	3.5e-08	0.53	0.08	0.92	FALSE
3	GTEx	Adipose Subcutaneous	SAAL1	0.10	0.11	enet	8	0.12	6.5e-10	5.3	-5.5	4.4e-08	0.45	0.08	0.92	FALSE
13	GTEx	Esophagus Gastroesophageal Junction	SAAL1	0.17	0.14	enet	9	0.13	1.9e-05	5.3	-5.5	4.8e-08	0.46	0.06	0.92	FALSE
23	GTEx	Skin Sun Exposed Lower leg	SAAL1	0.16	0.15	lasso	8	0.16	2.6e-13	4.8	-5.4	5.4e-08	0.44	0.08	0.92	FALSE
32	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SAAL1	0.07	0.07	enet	9	0.07	9.4e-09	5.5	-5.4	5.4e-08	0.49	0.01	0.99	FALSE
12	GTEx	Colon Transverse	SAAL1	0.15	0.05	lasso	5	0.08	1.9e-04	5.3	-5.4	5.6e-08	0.51	0.07	0.92	FALSE
9	GTEx	Breast Mammary Tissue	SAAL1	0.17	0.14	enet	11	0.12	8.5e-07	5.1	-5.4	6.0e-08	0.44	0.08	0.92	FALSE
7	GTEx	Artery Tibial	SAAL1	0.21	0.26	lasso	3	0.27	2.4e-21	5.3	-5.4	6.2e-08	0.44	0.07	0.93	FALSE
6	GTEx	Artery Aorta	SAAL1	0.20	0.15	enet	15	0.21	1.1e-11	5.3	-5.4	6.6e-08	0.54	0.08	0.92	FALSE
21	GTEx	Pituitary	SAAL1	0.22	0.12	lasso	4	0.10	2.2e-03	5.3	-5.4	6.7e-08	0.50	0.07	0.57	FALSE
43	The Cancer Genome Atlas	Thyroid Carcinoma	SAAL1	0.18	0.30	lasso	6	0.30	2.2e-29	5.3	-5.4	6.9e-08	0.44	0.02	0.98	FALSE
37	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MRGPRX3	0.12	0.09	lasso	4	0.09	8.9e-11	4.8	5.4	7.1e-08	-0.42	0.06	0.94	FALSE
20	GTEx	Pancreas	SAAL1	0.29	0.23	lasso	6	0.22	1.3e-09	5.3	-5.4	8.5e-08	0.50	0.06	0.94	FALSE
1	CommonMind	Brain Pre-frontal Cortex	SAAL1	0.15	0.17	enet	13	0.21	1.3e-24	4.5	-5.3	8.7e-08	0.55	0.11	0.89	FALSE
26	GTEx	Thyroid	SAAL1	0.16	0.10	lasso	6	0.12	3.3e-09	4.8	-5.3	8.7e-08	0.48	0.09	0.91	FALSE
41	The Cancer Genome Atlas	Prostate Adenocarcinoma	SAAL1	0.04	0.06	lasso	3	0.04	1.0e-04	5.3	-5.3	8.7e-08	0.46	0.02	0.98	FALSE
33	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SAAL1	0.15	0.22	lasso	6	0.22	1.2e-12	5.3	-5.3	9.3e-08	0.44	0.02	0.98	FALSE
5	GTEx	Adrenal Gland	SAAL1	0.15	0.16	lasso	3	0.12	5.1e-05	5.3	-5.3	9.6e-08	0.44	0.06	0.90	FALSE
22	GTEx	Skin Sun Exposed Lower leg	SERGEF	0.12	0.07	lasso	3	0.07	3.1e-06	5.0	5.3	1.0e-07	-0.73	0.11	0.89	FALSE
15	GTEx	Esophagus Mucosa	SAAL1	0.11	0.08	lasso	2	0.08	3.3e-06	5.3	-5.3	1.1e-07	0.47	0.08	0.92	FALSE
17	GTEx	Lung	SAAL1	0.23	0.13	lasso	8	0.15	7.4e-12	5.3	-5.3	1.2e-07	0.46	0.06	0.94	FALSE
36	The Cancer Genome Atlas	Lung Adenocarcinoma	SERGEF	0.04	0.00	blup	130	0.01	4.1e-02	5.0	5.3	1.3e-07	-0.70	0.03	0.63	FALSE
42	The Cancer Genome Atlas	Prostate Adenocarcinoma	SERGEF	0.06	0.00	blup	130	0.02	9.2e-03	5.4	5.3	1.4e-07	-0.54	0.05	0.83	FALSE
31	The Cancer Genome Atlas	Glioblastoma Multiforme	SAAL1	0.13	0.07	enet	5	0.08	2.4e-03	5.1	-5.2	1.8e-07	0.48	0.02	0.86	FALSE
14	GTEx	Esophagus Mucosa	SERGEF	0.14	0.20	lasso	3	0.19	9.5e-13	5.0	5.2	2.0e-07	-0.71	0.34	0.66	FALSE
39	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SERGEF	0.02	0.00	blup	130	0.01	8.6e-03	5.0	5.2	2.1e-07	-0.77	0.08	0.47	FALSE
8	GTEx	Brain Nucleus accumbens basal ganglia	SAAL1	0.43	0.25	lasso	5	0.20	4.3e-06	5.3	-5.1	2.7e-07	0.45	0.07	0.92	FALSE
30	The Cancer Genome Atlas	Colon Adenocarcinoma	SAAL1	0.09	0.11	lasso	2	0.08	2.2e-05	5.1	-5.1	2.8e-07	0.39	0.07	0.92	FALSE
18	GTEx	Muscle Skeletal	SERGEF	0.26	0.31	enet	11	0.35	9.7e-36	5.0	5.1	2.9e-07	-0.76	0.32	0.68	FALSE
19	GTEx	Nerve Tibial	SAAL1	0.14	0.15	lasso	1	0.15	1.4e-10	5.1	-5.1	2.9e-07	0.39	0.13	0.87	FALSE