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chr11:46,180,005-50,058,095

Best TWAS P=1.07e-32 · Best GWAS P=1.93e-30 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	AGBL2	0.03	0.02	enet	7	0.03	7.9e-05	-6.30	-6.4	1.3e-10	-0.31	0.90	0.01	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FAM180B	0.07	0.08	lasso	3	0.08	9.1e-10	8.19	9.8	1.4e-22	0.90	0.06	0.94	FALSE
3	CommonMind	Brain Pre-frontal Cortex	FOLH1	0.06	0.05	lasso	6	0.08	3.0e-10	-3.41	-5.3	1.1e-07	-0.22	0.11	0.89	FALSE
4	CommonMind	Brain Pre-frontal Cortex	MTCH2	0.03	0.00	bslmm	299	0.00	1.1e-01	-6.37	9.1	1.3e-19	0.74	0.03	0.77	FALSE
5	CommonMind	Brain Pre-frontal Cortex	PSMC3	0.04	0.00	enet	22	0.01	3.8e-02	-5.00	6.8	1.2e-11	0.53	0.06	0.63	FALSE
6	CommonMind	Brain Pre-frontal Cortex	PTPRJ	0.06	0.04	lasso	4	0.05	7.6e-07	-6.61	-6.6	4.0e-11	-0.25	0.97	0.03	FALSE
7	GTEx	Adipose Subcutaneous	PTPRJ	0.05	0.05	lasso	2	0.04	3.9e-04	-8.87	-8.6	8.6e-18	-0.31	0.32	0.05	FALSE
8	GTEx	Adipose Subcutaneous	C1QTNF4	0.16	0.22	lasso	4	0.22	2.5e-18	8.02	-9.4	3.4e-21	-0.90	0.49	0.51	FALSE
9	GTEx	Artery Aorta	C1QTNF4	0.09	0.10	lasso	1	0.08	3.2e-05	8.19	-8.2	2.7e-16	-0.85	0.07	0.89	FALSE
10	GTEx	Brain Cerebellar Hemisphere	MADD	0.44	0.14	lasso	7	0.21	4.0e-06	-4.94	5.5	5.0e-08	0.43	0.22	0.46	FALSE
11	GTEx	Brain Cerebellum	MADD	0.21	0.00	enet	13	0.11	3.3e-04	-2.63	6.5	6.0e-11	0.59	0.14	0.38	FALSE
12	GTEx	Brain Cortex	MTCH2	0.21	0.19	lasso	6	0.16	4.0e-05	11.23	11.9	1.1e-32	0.97	0.01	0.97	TRUE
13	GTEx	Brain Cortex	C1QTNF4	0.26	0.04	lasso	8	0.02	1.2e-01	-3.62	-6.7	2.2e-11	-0.77	0.03	0.39	FALSE
14	GTEx	Breast Mammary Tissue	C1QTNF4	0.10	0.06	lasso	2	0.03	8.5e-03	10.70	-10.8	3.3e-27	-0.88	0.04	0.86	FALSE
15	GTEx	Breast Mammary Tissue (Female)	MADD	0.13	0.04	lasso	3	0.05	1.3e-02	10.47	10.2	1.2e-24	0.86	0.04	0.53	FALSE
16	GTEx	Breast Mammary Tissue (Female)	ACP2	0.03	0.00	lasso	1	0.02	1.0e-01	-6.00	6.0	2.4e-09	0.32	0.02	0.18	FALSE
17	GTEx	Breast Mammary Tissue (Female)	PSMC3	0.02	0.01	lasso	1	0.04	2.5e-02	-8.70	8.7	3.4e-18	0.45	0.02	0.20	FALSE
18	GTEx	Cells Transformed fibroblasts	FNBP4	0.11	0.05	lasso	8	0.08	1.6e-06	-3.73	7.0	3.4e-12	0.84	0.36	0.64	FALSE
19	GTEx	Cells Transformed fibroblasts	PSMC3	0.07	0.00	enet	13	0.02	2.3e-02	-8.70	8.8	8.4e-19	0.78	0.03	0.73	FALSE
20	GTEx	Cells Transformed fibroblasts	C1QTNF4	0.13	0.11	enet	19	0.12	5.2e-09	11.27	-8.7	2.2e-18	-0.83	0.02	0.98	FALSE
21	GTEx	Cells Transformed fibroblasts	NDUFS3	0.08	0.01	lasso	2	0.01	3.3e-02	8.02	-8.4	3.6e-17	-0.84	0.03	0.85	FALSE
22	GTEx	Colon Transverse	C1QTNF4	0.07	0.02	lasso	6	0.03	2.0e-02	8.02	-10.1	7.3e-24	-0.93	0.04	0.86	FALSE
23	GTEx	Esophagus Gastroesophageal Junction	NUP160	0.18	0.02	enet	18	0.11	7.1e-05	-2.48	6.1	1.0e-09	0.56	0.15	0.48	FALSE
24	GTEx	Esophagus Mucosa	C1QTNF4	0.10	0.11	lasso	1	0.10	5.0e-07	8.19	-8.2	2.7e-16	-0.85	0.15	0.84	FALSE
25	GTEx	Esophagus Muscularis	MTCH2	0.09	0.04	lasso	6	0.02	1.8e-02	11.27	9.4	7.9e-21	0.89	0.03	0.95	FALSE
26	GTEx	Esophagus Muscularis	C1QTNF4	0.10	0.05	enet	23	0.06	1.4e-04	8.02	-8.8	1.4e-18	-0.85	0.14	0.84	FALSE
27	GTEx	Heart Atrial Appendage	ACP2	0.10	0.12	enet	7	0.10	2.7e-05	-2.96	5.4	7.4e-08	0.48	0.32	0.08	FALSE
28	GTEx	Heart Atrial Appendage	C1QTNF4	0.26	0.14	lasso	9	0.17	3.9e-08	8.19	-9.5	2.7e-21	-0.90	0.07	0.92	FALSE
29	GTEx	Heart Left Ventricle	C1QTNF4	0.10	0.11	lasso	1	0.09	1.1e-05	8.19	-8.2	2.7e-16	-0.85	0.13	0.63	FALSE
30	GTEx	Liver	PSMC3	0.15	0.09	lasso	4	0.07	5.9e-03	6.68	7.7	9.7e-15	0.69	0.04	0.59	FALSE
31	GTEx	Liver	C1QTNF4	0.25	0.14	enet	16	0.20	2.3e-06	8.19	-6.4	1.7e-10	-0.83	0.03	0.95	FALSE
32	GTEx	Lung	C1QTNF4	0.18	0.15	lasso	6	0.13	3.2e-10	10.74	-10.8	3.0e-27	-0.92	0.03	0.97	FALSE
33	GTEx	Muscle Skeletal	MTCH2	0.05	0.03	enet	15	0.04	1.5e-04	10.77	11.1	1.1e-28	0.92	0.02	0.98	FALSE
34	GTEx	Muscle Skeletal	SLC39A13	0.05	0.01	lasso	3	0.01	8.5e-02	-5.00	6.4	1.8e-10	0.32	0.11	0.03	FALSE
35	GTEx	Muscle Skeletal	C1QTNF4	0.09	0.14	lasso	3	0.13	9.9e-13	8.19	-9.3	8.9e-21	-0.92	0.16	0.84	FALSE
36	GTEx	Nerve Tibial	PTPRJ	0.05	0.03	enet	13	0.03	2.7e-03	-6.80	-8.7	4.8e-18	-0.56	0.11	0.48	FALSE
37	GTEx	Nerve Tibial	SLC39A13	0.07	0.01	enet	14	0.02	7.6e-03	10.46	8.7	3.3e-18	0.68	0.14	0.27	FALSE
38	GTEx	Nerve Tibial	C1QTNF4	0.20	0.23	enet	12	0.23	1.7e-16	8.19	-9.6	9.9e-22	-0.88	0.75	0.25	TRUE
39	GTEx	Pituitary	MADD	0.42	0.32	lasso	6	0.39	8.9e-11	-2.29	6.4	1.5e-10	0.69	0.06	0.91	FALSE
40	GTEx	Prostate	PSMC3	0.21	0.10	lasso	6	0.20	7.9e-06	-2.89	6.1	1.1e-09	0.48	0.15	0.10	FALSE
41	GTEx	Skin Not Sun Exposed Suprapubic	LRP4	0.13	0.00	lasso	7	0.02	3.5e-02	-1.24	-6.7	2.3e-11	-0.59	0.05	0.64	FALSE
42	GTEx	Skin Not Sun Exposed Suprapubic	SLC39A13	0.07	0.11	lasso	2	0.10	5.2e-06	-6.03	-6.0	2.0e-09	-0.29	0.38	0.03	TRUE
43	GTEx	Skin Not Sun Exposed Suprapubic	C1QTNF4	0.32	0.18	enet	33	0.20	5.2e-11	8.19	-8.5	1.9e-17	-0.80	0.06	0.94	FALSE
44	GTEx	Skin Sun Exposed Lower leg	PTPMT1	0.13	0.01	enet	33	0.03	3.0e-03	-3.70	-7.3	3.6e-13	-0.19	0.18	0.11	FALSE
45	GTEx	Skin Sun Exposed Lower leg	ACP2	0.16	0.14	enet	15	0.15	1.8e-12	-4.84	5.5	3.7e-08	0.43	1.00	0.00	FALSE
46	GTEx	Skin Sun Exposed Lower leg	PSMC3	0.20	0.05	lasso	7	0.10	1.2e-08	-8.70	10.1	5.8e-24	0.68	0.57	0.41	FALSE
47	GTEx	Skin Sun Exposed Lower leg	C1QTNF4	0.25	0.22	lasso	12	0.23	4.2e-19	8.19	-9.0	2.9e-19	-0.90	0.06	0.94	FALSE
48	GTEx	Spleen	PTPRJ	0.22	0.05	lasso	5	0.03	7.5e-02	-5.97	-6.3	3.3e-10	-0.25	0.08	0.06	FALSE
49	GTEx	Spleen	C1QTNF4	0.31	0.28	enet	29	0.34	1.8e-09	11.23	-9.2	4.5e-20	-0.94	0.02	0.97	FALSE
50	GTEx	Testis	MTCH2	0.17	0.16	lasso	3	0.16	1.0e-07	10.70	10.7	6.0e-27	0.88	0.07	0.93	FALSE
51	GTEx	Whole Blood	C1QTNF4	0.09	0.05	lasso	3	0.03	1.4e-03	11.22	-11.3	1.8e-29	-0.99	0.02	0.97	FALSE
52	METSIM	Adipose	ACP2	0.05	0.04	blup	302	0.06	1.7e-09	10.70	7.8	6.5e-15	0.67	0.04	0.96	FALSE
53	METSIM	Adipose	C1QTNF4	0.24	0.31	lasso	7	0.31	1.2e-46	11.32	-11.6	7.0e-31	-0.96	0.02	0.98	FALSE
54	METSIM	Adipose	MYBPC3	0.11	0.10	enet	26	0.11	1.0e-15	10.70	-9.2	3.7e-20	-0.84	0.06	0.94	FALSE
55	METSIM	Adipose	PSMC3	0.06	0.03	enet	28	0.04	2.3e-06	9.70	11.1	1.3e-28	0.82	0.05	0.95	FALSE
56	NTR	Blood	ACP2	0.01	0.00	enet	7	0.01	2.5e-03	-3.70	5.9	4.5e-09	0.41	0.44	0.08	FALSE
57	NTR	Blood	MTCH2	0.02	0.04	lasso	1	0.04	1.3e-11	11.27	-11.3	1.8e-29	-0.96	0.02	0.98	FALSE
58	NTR	Blood	PTPRJ	0.04	0.01	blup	285	0.02	8.5e-08	-8.72	-7.4	1.6e-13	-0.24	0.49	0.50	FALSE
59	ROSMAP	Brain Pre-frontal Cortex	FOLH1	0.11	0.17	lasso	8	0.16	1.4e-20	-7.32	-7.1	1.0e-12	-0.33	0.00	1.00	FALSE
60	ROSMAP	Brain Pre-frontal Cortex	MTCH2	0.35	0.40	enet	9	0.40	4.7e-56	11.32	11.0	3.2e-28	0.96	0.02	0.98	FALSE
61	ROSMAP	Brain Pre-frontal Cortex	PTPMT1	0.03	0.02	blup	270	0.02	3.8e-04	-6.03	-8.3	1.4e-16	-0.46	0.52	0.18	FALSE
62	ROSMAP	Brain Pre-frontal Cortex	ACP2	0.03	0.00	blup	295	0.02	1.5e-03	10.72	7.0	2.1e-12	0.65	0.26	0.40	TRUE
63	ROSMAP	Brain Pre-frontal Cortex	CELF1	0.03	0.01	bslmm	289	0.01	2.9e-02	-10.13	-9.9	2.6e-23	-0.55	0.08	0.58	FALSE
64	ROSMAP	Brain Pre-frontal Cortex	PSMC3	0.15	0.08	bslmm	285	0.10	5.1e-13	-4.99	8.3	1.3e-16	0.60	0.95	0.05	FALSE
65	ROSMAP	Brain Pre-frontal Cortex	C1QTNF4	0.05	0.06	blup	281	0.06	1.7e-08	10.72	-10.8	2.8e-27	-0.88	0.06	0.94	FALSE
66	YFS	Blood	FNBP4	0.02	0.01	bslmm	301	0.01	8.9e-05	0.63	5.6	1.9e-08	0.74	0.06	0.92	FALSE
67	YFS	Blood	NUP160	0.02	0.01	blup	290	0.01	1.7e-04	11.15	11.3	1.4e-29	0.80	0.02	0.96	FALSE
68	YFS	Blood	PSMC3	0.02	0.01	blup	289	0.01	2.8e-05	8.02	7.6	3.0e-14	0.72	0.24	0.65	FALSE
69	YFS	Blood	PTPRJ	0.02	0.01	bslmm	281	0.02	2.8e-06	-9.56	-7.1	1.3e-12	-0.27	0.37	0.24	FALSE
70	YFS	Blood	SPI1	0.65	0.18	enet	75	0.27	1.6e-87	10.80	-9.1	6.3e-20	-0.69	0.78	0.22	FALSE
71	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C1QTNF4	0.06	0.07	lasso	2	0.06	4.9e-06	11.29	-10.7	1.1e-26	-0.96	0.00	1.00	FALSE
72	The Cancer Genome Atlas	Breast Invasive Carcinoma	C1QTNF4	0.02	0.01	lasso	5	0.02	2.1e-04	-6.30	-8.5	2.0e-17	-0.64	0.04	0.46	FALSE
73	The Cancer Genome Atlas	Breast Invasive Carcinoma	MADD	0.11	0.03	enet	14	0.06	1.4e-11	-0.91	5.6	1.8e-08	0.57	0.04	0.96	FALSE
74	The Cancer Genome Atlas	Breast Invasive Carcinoma	MYBPC3	0.02	0.01	blup	43	0.01	3.4e-03	10.74	-8.7	3.4e-18	-0.79	0.01	0.97	FALSE
75	The Cancer Genome Atlas	Breast Invasive Carcinoma	NUP160	0.03	0.01	blup	44	0.01	1.9e-03	10.77	11.2	2.5e-29	0.85	0.01	0.63	FALSE
76	The Cancer Genome Atlas	Colon Adenocarcinoma	C1QTNF4	0.12	0.12	lasso	1	0.12	1.6e-07	8.19	-8.2	2.7e-16	-0.85	0.03	0.96	FALSE
77	The Cancer Genome Atlas	Colon Adenocarcinoma	KBTBD4	0.14	0.01	blup	13	0.02	1.6e-02	-3.40	9.7	2.4e-22	0.82	0.00	0.51	FALSE
78	The Cancer Genome Atlas	Colon Adenocarcinoma	PSMC3	0.09	0.05	blup	39	0.05	1.0e-03	-2.46	5.6	1.7e-08	0.63	0.02	0.83	FALSE
79	The Cancer Genome Atlas	Esophageal Carcinoma	C1QTNF4	0.39	0.33	blup	15	0.35	6.1e-12	8.19	-9.1	7.3e-20	-0.90	0.01	0.99	FALSE
80	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C1QTNF4	0.06	0.08	lasso	3	0.08	7.5e-09	11.32	-11.3	1.5e-29	-0.97	0.00	1.00	FALSE
81	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FNBP4	0.10	0.03	blup	45	0.05	7.7e-06	11.15	11.0	6.5e-28	0.82	0.00	0.99	TRUE
82	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MYBPC3	0.05	0.03	blup	43	0.04	6.0e-05	7.86	-7.9	3.5e-15	-0.74	0.01	0.98	FALSE
83	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NUP160	0.08	0.03	blup	42	0.04	6.7e-05	11.47	10.4	3.6e-25	0.91	0.01	0.98	FALSE
84	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PSMC3	0.05	0.01	lasso	3	0.02	9.4e-04	-5.99	10.9	1.6e-27	0.66	0.01	0.73	FALSE
85	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C1QTNF4	0.12	0.14	enet	4	0.16	6.5e-18	11.32	-10.4	2.5e-25	-0.95	0.00	1.00	FALSE
86	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PSMC3	0.05	0.04	lasso	3	0.05	3.8e-06	9.70	10.8	4.3e-27	0.79	0.01	0.99	FALSE
87	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PTPMT1	0.07	0.03	enet	4	0.03	6.8e-04	-5.58	-6.2	5.4e-10	-0.10	0.04	0.06	TRUE
88	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C1QTNF4	0.13	0.16	lasso	1	0.16	3.1e-09	11.27	-11.3	1.8e-29	-0.96	0.00	1.00	FALSE
89	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	NUP160	0.13	0.05	lasso	4	0.04	2.6e-03	-8.72	8.7	2.7e-18	0.39	0.09	0.04	FALSE
90	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PSMC3	0.07	0.07	enet	7	0.06	1.4e-04	10.46	10.6	2.0e-26	0.87	0.01	0.97	FALSE
91	The Cancer Genome Atlas	Brain Lower Grade Glioma	ACP2	0.09	0.04	enet	12	0.06	5.0e-07	-4.94	6.1	9.7e-10	0.52	0.59	0.39	FALSE
92	The Cancer Genome Atlas	Brain Lower Grade Glioma	MADD	0.08	0.01	lasso	5	0.05	3.1e-06	10.72	7.5	8.2e-14	0.60	0.00	0.95	FALSE
93	The Cancer Genome Atlas	Brain Lower Grade Glioma	MTCH2	0.11	0.11	lasso	2	0.10	6.4e-12	11.32	11.3	1.1e-29	0.97	0.00	1.00	FALSE
94	The Cancer Genome Atlas	Brain Lower Grade Glioma	MYBPC3	0.03	0.01	blup	43	0.02	3.2e-03	10.64	-9.1	9.9e-20	-0.74	0.00	0.90	FALSE
95	The Cancer Genome Atlas	Brain Lower Grade Glioma	PSMC3	0.10	0.05	blup	39	0.08	3.7e-09	10.70	8.5	1.6e-17	0.67	0.02	0.98	FALSE
96	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C1QTNF4	0.19	0.19	lasso	3	0.19	3.2e-09	11.32	-11.3	1.1e-29	-0.97	0.00	1.00	FALSE
97	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PSMC3	0.09	0.07	blup	39	0.06	8.7e-04	10.64	10.9	8.0e-28	0.85	0.01	0.99	FALSE
98	The Cancer Genome Atlas	Lung Adenocarcinoma	C1QTNF4	0.03	0.02	blup	15	0.02	1.3e-03	8.19	-8.5	2.0e-17	-0.89	0.00	0.96	FALSE
99	The Cancer Genome Atlas	Lung Adenocarcinoma	MYBPC3	0.04	0.02	enet	10	0.04	2.9e-05	10.74	-8.3	9.5e-17	-0.69	0.01	0.98	FALSE
100	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LOC440040	0.03	0.02	blup	71	0.01	2.4e-02	-4.23	-6.2	4.6e-10	-0.34	0.01	0.23	FALSE
101	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SLC39A13	0.06	0.01	blup	58	0.04	9.3e-04	-3.56	8.7	2.9e-18	0.58	0.02	0.36	TRUE
102	The Cancer Genome Atlas	Prostate Adenocarcinoma	FOLH1	0.03	0.01	blup	38	0.02	2.9e-03	-7.34	-6.5	7.7e-11	-0.29	0.00	0.98	FALSE
103	The Cancer Genome Atlas	Prostate Adenocarcinoma	NUP160	0.03	0.02	enet	7	0.02	6.3e-03	10.77	8.9	3.8e-19	0.95	0.01	0.90	FALSE
104	The Cancer Genome Atlas	Prostate Adenocarcinoma	PSMC3	0.02	0.02	blup	39	0.02	5.7e-03	10.70	11.9	1.4e-32	0.81	0.01	0.69	FALSE
105	The Cancer Genome Atlas	Stomach Adenocarcinoma	C1QTNF4	0.06	0.04	lasso	4	0.03	4.3e-03	11.26	-10.8	2.9e-27	-0.96	0.00	0.93	FALSE
106	The Cancer Genome Atlas	Thyroid Carcinoma	C1QTNF4	0.04	0.01	blup	15	0.03	7.9e-04	8.19	-7.5	5.9e-14	-0.79	0.01	0.85	FALSE