Best TWAS P=1.29e-18 · Best GWAS P=3.34e-19 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | DCUN1D2 | 0.04 | 0.02 | lasso | 6 | 0.03 | 4.0e-04 | 8.0 | -7.5 | 6.5e-14 | -0.84 | 0.18 | 0.69 | FALSE |
2 | GTEx | Brain Caudate basal ganglia | DCUN1D2 | 0.18 | -0.01 | enet | 11 | 0.00 | 4.7e-01 | 3.6 | -5.3 | 8.9e-08 | -0.74 | 0.05 | 0.26 | FALSE |
3 | GTEx | Brain Cerebellar Hemisphere | TMCO3 | 0.17 | 0.07 | lasso | 11 | 0.11 | 8.9e-04 | 8.1 | 8.5 | 2.6e-17 | 0.82 | 0.05 | 0.69 | TRUE |
4 | GTEx | Brain Hippocampus | TMEM255B | 0.23 | 0.04 | enet | 24 | 0.05 | 2.6e-02 | -1.1 | 6.0 | 2.6e-09 | 0.26 | 0.04 | 0.47 | FALSE |
5 | GTEx | Muscle Skeletal | TMCO3 | 0.25 | 0.18 | lasso | 6 | 0.23 | 2.7e-22 | 8.3 | 8.2 | 1.8e-16 | 0.91 | 0.01 | 0.99 | FALSE |
6 | GTEx | Nerve Tibial | TMCO3 | 0.09 | 0.06 | lasso | 3 | 0.04 | 4.5e-04 | 9.0 | -8.8 | 1.3e-18 | -1.00 | 0.00 | 0.99 | TRUE |
7 | GTEx | Thyroid | TMCO3 | 0.22 | 0.12 | lasso | 2 | 0.13 | 4.0e-10 | 7.0 | -6.3 | 3.1e-10 | -0.75 | 0.42 | 0.57 | FALSE |
8 | METSIM | Adipose | ADPRHL1 | 0.07 | 0.00 | bslmm | 392 | 0.02 | 4.6e-04 | -6.9 | 5.7 | 1.4e-08 | 0.26 | 0.04 | 0.47 | TRUE |
9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DCUN1D2 | 0.03 | 0.02 | blup | 79 | 0.04 | 2.2e-05 | 8.4 | -6.9 | 5.6e-12 | -0.82 | 0.04 | 0.95 | FALSE |
10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RASA3 | 0.04 | 0.01 | blup | 90 | 0.01 | 7.2e-03 | 4.4 | 6.4 | 1.2e-10 | 0.02 | 0.09 | 0.13 | TRUE |
11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TMCO3 | 0.05 | 0.04 | blup | 78 | 0.04 | 5.6e-05 | 8.2 | -6.7 | 2.6e-11 | -0.85 | 0.03 | 0.97 | FALSE |
12 | The Cancer Genome Atlas | Lung Adenocarcinoma | GRK1 | 0.04 | 0.02 | blup | 36 | 0.02 | 7.7e-04 | 7.1 | 7.3 | 2.6e-13 | 0.71 | 0.00 | 0.98 | FALSE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | GRK1 | 0.23 | 0.19 | enet | 9 | 0.24 | 1.1e-22 | 4.7 | 6.3 | 3.3e-10 | 0.60 | 1.00 | 0.00 | FALSE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | TMCO3 | 0.27 | 0.04 | enet | 14 | 0.13 | 9.1e-13 | 7.0 | -6.9 | 4.1e-12 | -0.74 | 0.00 | 1.00 | FALSE |