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chr13:113,378,882-115,106,996

Best TWAS P=1.29e-18 · Best GWAS P=3.34e-19 conditioned to 1

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
6	GTEx	Nerve Tibial	TMCO3	0.09	0.06	lasso	3	0.04	4.5e-04	9.0	-8.8	1.3e-18	-1.00	0.00	0.99	TRUE
3	GTEx	Brain Cerebellar Hemisphere	TMCO3	0.17	0.07	lasso	11	0.11	8.9e-04	8.1	8.5	2.6e-17	0.82	0.05	0.69	TRUE
10	The Cancer Genome Atlas	Brain Lower Grade Glioma	RASA3	0.04	0.01	blup	90	0.01	7.2e-03	4.4	6.4	1.2e-10	0.02	0.09	0.13	TRUE
8	METSIM	Adipose	ADPRHL1	0.07	0.00	bslmm	392	0.02	4.6e-04	-6.9	5.7	1.4e-08	0.26	0.04	0.47	TRUE
5	GTEx	Muscle Skeletal	TMCO3	0.25	0.18	lasso	6	0.23	2.7e-22	8.3	8.2	1.8e-16	0.91	0.01	0.99	FALSE
1	CommonMind	Brain Pre-frontal Cortex	DCUN1D2	0.04	0.02	lasso	6	0.03	4.0e-04	8.0	-7.5	6.5e-14	-0.84	0.18	0.69	FALSE
12	The Cancer Genome Atlas	Lung Adenocarcinoma	GRK1	0.04	0.02	blup	36	0.02	7.7e-04	7.1	7.3	2.6e-13	0.71	0.00	0.98	FALSE
14	The Cancer Genome Atlas	Thyroid Carcinoma	TMCO3	0.27	0.04	enet	14	0.13	9.1e-13	7.0	-6.9	4.1e-12	-0.74	0.00	1.00	FALSE
9	The Cancer Genome Atlas	Brain Lower Grade Glioma	DCUN1D2	0.03	0.02	blup	79	0.04	2.2e-05	8.4	-6.9	5.6e-12	-0.82	0.04	0.95	FALSE
11	The Cancer Genome Atlas	Brain Lower Grade Glioma	TMCO3	0.05	0.04	blup	78	0.04	5.6e-05	8.2	-6.7	2.6e-11	-0.85	0.03	0.97	FALSE
7	GTEx	Thyroid	TMCO3	0.22	0.12	lasso	2	0.13	4.0e-10	7.0	-6.3	3.1e-10	-0.75	0.42	0.57	FALSE
13	The Cancer Genome Atlas	Thyroid Carcinoma	GRK1	0.23	0.19	enet	9	0.24	1.1e-22	4.7	6.3	3.3e-10	0.60	1.00	0.00	FALSE
4	GTEx	Brain Hippocampus	TMEM255B	0.23	0.04	enet	24	0.05	2.6e-02	-1.1	6.0	2.6e-09	0.26	0.04	0.47	FALSE
2	GTEx	Brain Caudate basal ganglia	DCUN1D2	0.18	-0.01	enet	11	0.00	4.7e-01	3.6	-5.3	8.9e-08	-0.74	0.05	0.26	FALSE