Hub : Genes

TMEM255B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Frontal Cortex BA9 0.2291 0.1149 6.9e-03 0.084 NA 0.081 NA 0.134 3.0e-03 NA 3.6e-03 NA 2.1e-04
2 GTEx Brain Hippocampus 0.2298 0.0996 5.0e-03 0.036 NA 0.050 NA 0.010 5.1e-02 NA 2.7e-02 NA 1.9e-01
3 GTEx Cells Transformed fibroblasts 0.6080 0.0410 0.0e+00 0.496 NA 0.567 NA 0.530 4.1e-42 NA 5.4e-51 NA 3.6e-46
4 METSIM Adipose 0.0866 0.0255 2.7e-07 0.022 0.054 0.066 0.057 0.051 2.6e-04 1.5e-08 4.1e-10 6.7e-09 3.6e-08

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.5 0.8 1.4 1.2 0.7 -0.3 1.2
Bipolar Disorder or Schizophrenia 0.1 0.3 0.5 0.6 -0.0 -0.7 0.7
Depressed Affect (Nagel 2018) 0.2 0.3 0.5 0.2 -0.6 -0.7 0.7
Depression (Nagel 2018) 1.0 1.5 3.0 0.3 1.0 1.5 1.7
Intelligence (Savage-Jansen 2018) 1.1 3.3 7.4 -0.9 -2.7 -1.5 -1.7
Neuroticism (Nagel 2018) 0.3 0.8 1.9 0.8 -0.7 -1.4 -0.1
Schizophrenia (2018) 0.1 0.2 0.4 -0.2 -0.6 -0.6 -0.1
Schizophrenia vs Biploar Disorder 0.1 0.2 0.3 -0.2 0.5 0.6 0.1
Worry (Nagel 2018) 0.9 1.9 4.3 -0.2 -1.2 -2.1 -1.4
Alzheimer’s Disease (in mother) 0.2 0.2 0.5 -0.7 0.1 -0.5 -0.4
Alzheimer’s Disease (in father) 0.7 0.8 1.5 -1.2 0.4 -0.5 -1.1
Alzheimer’s Disease (including proxy) 0.3 0.5 0.7 -0.8 0.6 -0.5 -0.7
Crohns Disease (2017) 0.1 0.1 0.2 0.5 -0.1 -0.4 0.3
Irritable Bowel Disease (IBD) 0.1 0.2 0.5 -0.1 0.2 -0.7 -0.2
Ulcerative Colitis (UC) 0.1 0.3 0.5 -0.0 0.5 -0.7 -0.6
Major Depression (MDD) 0.2 0.2 0.8 0.0 0.0 -0.9 0.0
Reaction Time 0.2 0.4 1.1 -1.0 -0.1 -0.7 0.5
Verbal and Numeric Reasoning (VNR) 1.3 3.0 5.5 -0.6 -2.3 -1.9 -1.7
Breast Cancer 0.5 1.2 2.6 -1.6 -0.4 0.0 -1.4
Ovarian Cancer 0.3 0.4 0.6 0.7 -0.1 0.8 0.7
Prostate Cancer 0.8 1.1 3.5 0.8 -0.4 -0.2 1.9
Age at First Birth 0.3 0.4 0.6 0.4 0.5 -0.8 -0.7
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.7 1.0 2.2 -0.1 -0.1 -1.4 -1.5
Coronary Artery Disease (CAD) 0.4 0.5 1.6 -0.5 0.0 1.3 0.4
Crohns Disease (2012) 0.0 0.1 0.2 0.4 0.1 -0.0 0.3
Mean Putamen Volume 0.1 0.1 0.5 -0.7 0.3 -0.2 -0.0
Fasting Glucose 0.1 0.1 0.2 -0.4 -0.2 0.4 -0.4
HbA1C 3.6 4.0 7.6 2.1 2.8 1.0 1.7
HDL Cholesterol 0.3 0.4 0.9 -0.7 -1.0 -0.4 -0.3
LDL Cholesterol 2.0 3.1 4.5 -0.9 1.8 2.0 2.1
Lupus 0.1 0.2 0.3 -0.6 -0.1 0.0 0.5
Neuroticism (2016) 0.2 0.3 1.0 -0.2 -0.4 -1.0 -0.0
Primary Biliary Cirrhosis 0.6 0.9 1.6 0.7 1.1 -1.3 -0.6
Rheumatoid Arthritis 1.4 2.0 6.8 0.2 -0.5 -2.6 -0.9
Schizophrenia (2014) 0.1 0.3 0.5 0.2 -0.6 -0.4 0.7
Triglycerides 0.7 1.2 3.2 1.0 0.8 0.3 1.8
Type 2 Diabetes (T2D) (2012) 0.7 0.8 2.3 -0.8 0.0 0.5 1.5
Ulcerative Colitis 2.2 3.1 6.9 1.7 2.6 0.9 1.4
Blood Eosinophil Count 0.3 1.9 5.3 -1.0 1.2 -2.3 -0.4
Blood Platelet Count 0.4 4.3 6.6 2.4 1.8 -2.6 -1.1
Blood Red Count 3.1 30.3 37.7 5.1 4.8 6.1 5.8
Blood White Count 2.5 18.9 35.5 3.0 6.0 3.9 4.0
Heel T-Score 0.2 1.3 2.5 -0.4 -0.9 -1.2 -1.6
BMI 0.3 2.0 4.4 0.6 -2.1 -1.7 -0.1
Height 0.4 7.6 16.2 -0.5 -1.8 -3.2 -4.0
Waist Hip Ratio (WHR) 2.4 10.8 16.1 3.4 3.0 2.6 4.0
Systolic Blood Pressure 1.7 8.6 11.4 2.6 2.7 3.0 3.4
Smoking Status 0.2 0.5 0.6 0.7 -0.6 -0.7 -0.8
Allergy or Eczema 0.9 2.3 4.7 -0.2 -2.1 -2.2 -0.2
Cardiovascular Disease 0.8 2.6 6.4 -1.2 0.8 1.3 2.5
Hypothyroidism (self reported) 0.2 0.6 1.6 -0.6 -1.3 -0.2 -0.4
Respiratory disease 0.2 0.4 1.6 -0.1 0.3 0.1 1.3
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.6 -0.3 -0.8 -0.0 0.0
Lung FEV1/FVC ratio 0.7 3.4 6.2 0.7 1.9 2.5 1.8
Lung FVC 0.1 0.4 1.0 -0.5 0.5 -0.4 -1.0
Neuroticism 0.2 0.5 1.2 0.3 -1.1 -0.8 0.3
Chronotype (morning person) 0.3 0.6 1.5 1.2 0.7 0.2 -0.6
Hair Pigment 0.0 0.8 2.4 0.6 -0.1 -0.6 1.6
Tanning 0.1 1.4 2.8 1.7 0.9 0.7 1.3
Hand grip strength (left) 1.0 2.6 3.7 1.9 1.6 1.8 1.0
Number of treatments/medications taken 1.4 2.5 4.5 0.9 1.2 2.1 1.9
Average weekly spirits intake 0.3 0.4 0.7 -0.2 0.5 0.7 0.9
Sensitivity / hurt feelings 0.3 0.5 0.7 0.8 -0.8 -0.8 0.3
Frequency of depressed mood in last 2 weeks 0.4 0.6 1.8 -1.3 -0.6 -0.4 0.2
Hearing difficulty/problems: Yes 0.4 0.6 1.7 1.3 0.5 -0.2 0.5
Relative age of first facial hair 0.2 0.4 1.2 0.2 0.4 -1.1 0.3
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 1.2 0.7 0.5 0.0 1.1
Ever used hormone-replacement therapy (HRT) 0.6 0.7 1.5 -0.5 -0.1 -1.2 1.0
Ever had hysterectomy (womb removed) 0.4 0.4 0.8 0.8 0.9 0.4 0.1
Systolic blood pressure, automated reading 0.8 2.4 3.1 1.5 1.4 1.4 1.8
Eye problems/disorders: Diabetes related eye disease 1.3 1.4 3.2 -1.8 -0.2 1.4 0.7
Angina 0.6 0.8 2.2 -0.8 1.5 0.3 -0.5
Medication for hormone replacement therapy 0.5 0.6 1.5 0.6 0.1 0.7 1.2
Vitamin and mineral supplements 2.7 3.7 5.2 2.3 2.1 1.8 1.5
Supplements: Zinc 2.0 2.1 4.0 -1.4 -0.5 -1.6 -2.0
Medication: Co-codamol 0.2 0.3 0.8 0.2 -0.4 -0.9 -0.3
Medication: Metformin 0.9 1.2 1.9 0.6 0.9 1.4 1.3
Diabetes (father) 1.2 1.5 2.7 1.7 1.5 -0.0 1.0
Diabetes (mother) 0.1 0.2 0.3 -0.2 -0.6 -0.5 -0.3
Severe depression (siblings) 1.0 1.2 3.5 -0.6 -1.9 -0.2 -0.9
Pack years adult smoking proportion 1.1 1.6 5.4 2.3 0.9 -0.6 -0.1
Impedance of leg (right) 0.2 1.0 2.1 0.6 1.5 0.9 0.7
Leg fat-free mass (left) 0.3 1.5 2.5 0.5 -1.1 -1.6 -1.4
Trunk fat percentage 0.2 0.6 1.2 0.6 -0.2 -1.1 1.0
Hand grip strength (right) 0.3 0.8 1.9 1.0 0.4 1.4 0.2
Townsend deprivation index at recruitment 1.0 1.4 2.4 -1.0 -1.5 -1.4 -0.7
Current tobacco smoking 0.4 0.7 2.4 -0.1 0.4 0.2 -1.6
Average weekly fortified wine intake 0.9 1.1 2.4 -0.0 0.3 1.4 1.6
Maternal smoking around birth 0.3 0.4 1.0 -0.8 0.3 0.1 -1.0
Fed-up feelings 0.5 0.9 2.5 0.5 -0.9 -0.2 1.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.6 2.3 0.2 -0.0 0.4 1.5
Relative age voice broke 0.6 0.9 1.9 0.9 0.4 -0.9 1.4
Taking other prescription medications 0.7 1.0 2.4 -0.1 0.5 1.5 1.2
Age when periods started (menarche) 0.2 0.4 0.7 0.8 0.3 0.7 0.7
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 0.8 -0.9 -0.4 -0.7 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 1.7 -0.8 -1.1 -1.3 -0.4
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.8 0.5 -0.3 -0.9 0.4
Qualifications: CSEs or equivalent 0.1 0.1 0.1 0.3 0.3 0.3 0.3
Serious illness, injury or assault to yourself 0.6 0.7 1.6 -0.4 -0.2 1.0 1.3
High blood pressure 0.2 0.5 1.3 -1.1 -0.0 0.0 0.9
Hayfever, allergic rhinitis or eczema 0.6 1.2 3.1 -0.3 -1.8 -1.3 -0.3
Multivitamins +/- minerals 3.1 4.0 6.7 -1.6 -2.6 -2.3 -1.2
Stomach or abdominal pain in last month 0.3 0.4 1.0 -1.0 -0.6 -0.1 -0.5
Supplements: Glucosamine 0.5 0.6 1.3 0.2 1.1 1.1 -0.1
Diverticular disease/diverticulitis (self-reported) 1.2 1.4 2.0 1.3 -1.0 -1.4 0.8
Medication: Atenolol 0.3 0.3 1.0 0.1 1.0 -0.1 -0.5
Medication: Levothyroxine sodium 0.6 0.9 2.2 0.9 0.6 1.5 0.6
Sitting height 0.1 0.6 2.1 0.2 0.3 0.2 -1.4
Chronic bronchitis/emphysema (father) 0.8 1.0 1.5 -1.1 -0.3 -1.2 -1.1
High blood pressure (mother) 0.7 1.0 2.0 0.7 0.8 1.0 1.4
Body mass index (BMI) 0.2 1.0 2.6 1.6 0.2 -0.4 1.0
Impedance of leg (left) 0.2 0.9 2.6 0.7 1.6 0.6 0.5
Leg predicted mass (left) 0.3 1.6 2.5 0.5 -1.2 -1.6 -1.5
Trunk fat mass 0.2 0.7 1.3 1.1 -0.1 -1.0 0.6
Waist circumference 0.6 2.2 5.9 2.4 0.5 -0.3 1.6
Number of incorrect matches in round 1.7 2.9 3.8 1.9 1.9 1.9 0.8
Past tobacco smoking 0.2 0.4 1.2 -0.5 1.1 0.4 -0.3
Alcohol usually taken with meals 0.5 0.9 2.2 -1.5 0.1 1.1 0.2
Nervous feelings 0.2 0.4 1.5 -0.2 -0.3 -1.2 -0.3
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 1.8 -0.6 -1.3 -1.3 -0.6
Hearing difficulty/problems with background noise 1.5 2.4 4.4 -1.2 -2.1 -1.6 -1.1
Hair/balding pattern: Pattern 2 0.3 0.4 1.3 0.1 1.1 0.0 -0.5
Had menopause 0.5 0.6 1.2 0.4 -0.3 -1.0 1.1
Had other major operations 1.3 1.6 3.9 0.6 0.8 1.1 2.0
Forced vital capacity (FVC) 0.5 2.1 5.1 -0.9 -0.9 -1.2 -2.3
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 1.1 0.1 -0.6 -1.1 -0.1
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 2.5 1.6 -0.2 0.3 1.3
Qualifications: None of the above 0.8 1.8 6.9 0.3 2.6 0.4 0.3
Financial difficulties in last 2 years 1.2 1.6 2.3 -1.2 -1.0 -1.5 -1.3
Mouth/teeth dental problems 0.5 0.7 1.8 0.8 1.3 0.7 0.0
Heart attack 1.0 1.3 3.8 0.9 1.9 0.3 -0.8
Allergy 0.2 0.4 0.8 -0.6 0.4 0.7 -0.9
Pain all over the body in last month 0.9 0.9 2.3 1.0 0.6 -1.5 -0.4
Diabetes (self-reported) 0.1 0.2 0.4 -0.5 -0.6 0.1 0.4
Hayfever/allergic rhinitis (self-reported) 1.0 1.3 1.6 -1.3 -1.3 -1.2 -0.7
Medication: Ramipril 0.9 1.2 2.3 0.2 0.8 1.5 1.3
Medication: Simvastatin 1.8 2.6 4.6 1.5 2.1 1.6 1.2
Fluid intelligence score 3.0 6.2 10.7 -0.8 -3.3 -2.7 -2.5
Illnesses of siblings 0.4 0.6 1.0 0.0 -0.9 1.0 -0.8
Neuroticism score 0.5 1.1 2.2 0.1 -1.5 -1.4 0.1
Weight 0.2 1.0 2.4 1.5 -0.2 -1.2 -0.3
Impedance of arm (right) 0.4 2.0 4.4 -2.1 -1.4 -1.2 0.1
Arm fat percentage (right) 0.2 0.6 1.5 0.6 -0.3 -0.8 1.2
Trunk fat-free mass 0.2 1.3 3.6 1.9 0.1 -0.4 -1.2
Hip circumference 0.6 2.6 6.5 0.3 -1.7 -2.5 -0.9
Time employed in main current job 0.5 0.6 1.2 -0.1 -0.7 -1.1 -0.8
Alcohol intake versus 10 years previously 0.3 0.4 1.1 0.6 -0.2 -0.6 -1.0
Father’s age at death 0.9 1.2 2.4 -1.2 -1.6 -1.0 0.3
Worrier / anxious feelings 0.6 1.1 2.5 -0.2 -0.9 -1.6 -1.1
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 1.3 0.8 -0.8 -0.9 1.1
Falls in the last year 0.5 0.7 1.4 0.9 0.7 -1.2 -0.3
Hair/balding pattern: Pattern 3 0.2 0.4 1.0 0.1 -0.6 -1.0 0.3
Number of live births 0.5 0.7 1.4 0.7 1.2 0.6 -0.7
Forced expiratory volume in 1-second (FEV1) 0.2 0.8 2.3 -0.7 -0.4 -0.4 -1.5
Pulse rate 2.6 4.4 8.0 2.4 2.8 1.5 1.3
Happiness 1.7 2.1 4.3 1.9 -0.1 0.8 2.1
Noisy workplace 0.5 0.6 1.2 -0.1 -0.7 -1.1 -0.8
Qualifications: A levels/AS levels or equivalent 1.3 2.8 8.6 -1.1 -2.9 -0.9 -0.8
Serious illness, injury or assault of a close relative in last 2 years 2.3 2.6 5.9 0.0 0.9 2.4 2.0
Mouth/teeth dental problems: Dentures 0.3 0.4 0.7 -0.6 0.8 0.5 -0.6
Asthma 0.2 0.4 1.4 0.2 0.4 -0.2 1.2
Medication: Ibuprofen (e.g. Nurofen) 3.1 4.0 8.6 0.3 1.2 2.4 2.9
Medication: Cholesterol lowering 5.9 9.1 13.7 1.8 3.4 3.7 2.8
Depression (self-reported) 0.6 0.7 1.7 1.0 -0.1 0.5 1.3
Medication: Lansoprazole 2.4 2.7 3.9 1.2 1.5 1.8 2.0
Prospective memory result 2.3 2.8 6.0 1.2 1.4 1.3 2.5
Lung cancer (father) 2.3 2.7 4.5 -1.6 -2.1 -0.6 -1.8
Illnesses of mother 0.6 0.7 1.1 -1.1 -0.1 -0.7 -1.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.6 1.2 -0.2 0.9 1.1 -0.7
Pulse wave Arterial Stiffness index 0.2 0.3 1.0 -0.3 0.2 0.3 -1.0
Impedance of arm (left) 0.7 3.0 7.6 -2.8 -1.8 -1.1 -0.1
Arm fat mass (right) 0.2 0.7 1.9 1.4 0.1 -0.8 0.6
Trunk predicted mass 0.2 1.3 3.2 1.8 0.0 -0.4 -1.3
Standing height 0.3 2.8 7.4 0.1 -0.8 -1.7 -2.7
Length of working week for main job 2.1 2.3 4.8 -0.3 -1.7 -2.2 -1.1
Exposure to tobacco smoke at home 0.6 0.6 1.4 0.5 1.2 -0.9 -0.5
Breastfed as a baby 0.3 0.4 0.9 1.0 0.3 -0.3 -0.7
Tense / ‘highly strung’ 1.6 2.7 6.0 -0.2 -1.4 -2.5 -1.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.9 1.4 2.5 -0.8 -1.5 -1.6 -0.3
Hair/balding pattern: Pattern 4 0.3 0.7 1.4 -1.2 -1.0 0.5 -0.5
Birth weight of first child 0.7 1.3 2.3 -1.5 -1.3 -0.7 -0.7
Peak expiratory flow (PEF) 0.2 0.6 1.3 0.4 0.3 -0.9 -1.1
Pulse wave reflection index 2.6 3.2 6.3 -1.4 -2.5 -1.8 -1.2
Ever highly irritable/argumentative for 2 days 1.7 2.1 4.7 0.9 -2.2 -1.7 0.1
Loud music exposure frequency 0.8 0.8 2.0 0.7 1.4 0.8 -0.2
Qualifications: O levels/GCSEs or equivalent 2.0 3.2 4.7 -1.3 -2.2 -2.1 -1.4
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 0.8 0.3 -0.9 0.0 0.3
Blood clot in the leg (DVT) 1.0 1.2 3.7 0.8 1.9 0.1 -0.7
Medication: Paracetamol 0.3 0.5 0.7 0.8 0.4 0.6 0.8
Headache pain in last month 0.4 0.6 1.2 0.2 0.6 1.1 0.9
Medication for cholesterol, blood pressure or diabetes 5.9 9.8 15.1 -1.7 -2.7 -3.8 -3.9
Glaucoma (self-reported) 0.9 1.1 1.5 0.8 -1.2 -1.1 -0.9
Gout (self-reported) 0.6 0.8 1.8 -0.0 1.4 1.1 -0.4
Hypothyroidism/myxoedema (self-reported) 0.2 0.5 1.3 0.2 0.4 1.1 0.6
Medication: Amlodipine 0.2 0.3 1.1 0.1 -0.2 0.5 1.0
Medication: Ventolin 100micrograms inhaler 0.6 0.7 1.6 -1.0 -1.3 -0.6 0.2
Birth weight 1.0 2.1 3.0 -1.1 -1.6 -1.2 -1.7
Chronic bronchitis/emphysema (mother) 0.4 0.5 1.0 -1.0 -0.6 -0.4 -0.7
High blood pressure (siblings) 0.5 0.7 1.5 0.6 0.4 -1.2 0.8
Forced vital capacity (FVC), Best measure 0.2 0.7 2.2 -0.7 0.2 0.4 -1.5
Body fat percentage 0.2 0.8 1.8 1.1 0.1 -0.6 1.4
Leg fat percentage (right) 0.5 1.9 4.1 2.0 1.2 0.4 1.5
Arm fat-free mass (right) 0.3 1.5 3.5 1.9 0.4 -0.6 -1.3
Exposure to tobacco smoke outside home 0.5 0.6 1.8 -0.2 1.3 0.8 0.2
Comparative body size at age 10 0.0 0.1 0.3 -0.3 0.2 0.2 -0.5
Number of full brothers 0.8 1.1 2.1 1.4 -0.3 -1.4 -0.2
Worry too long after embarrassment 1.8 2.9 5.6 0.3 -1.7 -2.4 -1.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.6 0.7 -0.8 -0.1 0.3
Wheeze or whistling in the chest in last year 0.0 0.0 0.1 0.1 -0.1 0.1 0.4
Number of children fathered 0.7 0.8 2.7 0.2 -0.1 -0.5 1.7
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.3 0.7 -0.2 0.1 0.8 0.6
Age at first live birth 0.1 0.1 0.3 0.6 -0.1 0.0 0.5
Pulse wave peak to peak time 0.2 0.2 0.6 0.2 -0.3 -0.4 0.8
Health satisfaction 0.8 1.0 3.3 0.7 -0.1 0.4 1.8
Shortness of breath walking on level ground 0.1 0.1 0.3 -0.6 0.1 -0.1 0.1
Qualifications: College or University degree 0.5 1.6 5.4 -0.3 -2.3 -0.2 -0.8
Eye problems/disorders: None of the above 0.4 0.5 1.3 1.1 0.7 -0.3 0.1
Mouth/teeth dental problems: Loose teeth 0.2 0.3 0.8 -0.2 -0.9 -0.5 -0.1
Emphysema/chronic bronchitis 1.6 1.8 2.4 -1.6 -0.4 -1.5 -1.5
Medication for pain relief, constipation, heartburn 2.1 3.5 4.7 -1.1 -2.2 -2.0 -2.1
Neck or shoulder pain in last month 0.2 0.3 0.7 -0.9 0.4 0.1 0.6
Medication: Blood pressure 2.7 4.7 9.1 0.7 1.4 2.7 3.0
Angina (self-reported) 0.5 0.7 1.5 -0.9 1.2 0.0 -0.6
Migraine (self-reported) 0.5 0.6 1.7 0.3 1.3 -0.5 -0.6
Medication: Ibuprofen 3.0 3.5 7.7 0.3 1.3 2.1 2.8
Medication: Allopurinol 0.4 0.6 1.4 0.1 1.2 0.9 0.3
Medication: Omeprazole 0.1 0.1 0.2 -0.3 -0.0 0.2 0.4
Medication: Seretide 50 evohaler 2.0 2.3 3.7 -1.9 -1.5 -1.1 -1.4
Mean time to correctly identify matches 0.2 0.4 1.3 -0.3 0.0 0.0 1.2
Heart disease (mother) 0.7 0.9 2.8 -0.4 -1.7 -0.1 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 1.6 1.0 1.3 1.2 1.1
Whole body fat mass 0.2 0.9 2.4 1.6 0.2 -0.8 0.7
Leg fat mass (right) 0.3 1.3 4.0 2.0 0.6 -0.1 1.0
Arm predicted mass (right) 0.3 1.3 2.9 1.7 0.4 -0.5 -1.4
Pulse rate, automated reading 2.6 8.3 14.3 2.8 3.8 1.7 2.8
Alcohol intake frequency. 0.2 0.4 0.8 -0.9 0.1 -0.3 -0.8
Comparative height size at age 10 0.3 1.9 5.7 -0.4 -0.8 -1.1 -2.4
Number of full sisters 0.3 0.3 0.7 0.9 0.6 0.5 0.0
Suffer from ‘nerves’ 0.6 0.9 2.3 -0.7 -0.7 -1.5 -0.7
Overall health rating 0.2 0.5 1.2 -0.0 0.9 0.0 1.1
Chest pain or discomfort 0.2 0.3 0.6 -0.5 0.7 0.3 0.8
Had major operations 1.4 1.7 3.4 1.2 0.1 1.3 1.8
Age at last live birth 1.2 1.8 2.7 0.1 -1.6 -1.7 -1.4
Family relationship satisfaction 1.8 2.3 6.9 0.6 -0.9 1.0 2.6
Leg pain on walking 1.7 2.1 3.5 -0.4 -1.9 -1.8 -1.2
Qualifications: NVQ or HND or HNC or equivalent 0.0 0.1 0.1 0.3 0.3 0.1 0.3
Commuting to job workplace: Car/motor vehicle 1.9 2.2 3.4 1.8 1.3 1.6 1.1
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 2.5 1.6 1.2 -0.6 0.4
Medication: Aspirin 1.3 1.8 5.5 1.0 2.3 0.6 0.5
Supplements: Vitamin C 2.1 2.5 4.7 -2.2 -1.3 -0.6 -1.8
Knee pain experienced in last month 1.0 1.6 3.6 -0.6 -0.9 -1.9 -1.3
Hypertension (Self-reported) 0.2 0.5 1.1 -1.1 0.2 0.1 0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.9 1.5 0.4 1.2 1.0 0.9
Illnesses of father: Heart disease 1.3 1.8 3.6 0.4 0.5 1.9 1.8
Illnesses of siblings: Diabetes 0.9 1.1 2.7 1.1 1.6 0.1 0.5
Smoking status: Previous 0.6 0.9 2.1 0.3 -1.5 -1.2 0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.3 2.9 -1.0 -1.7 -0.6 -0.9
Whole body fat-free mass 0.2 1.3 2.1 1.5 -0.4 -1.0 -1.4
Leg fat-free mass (right) 0.3 1.7 2.7 0.6 -1.2 -1.6 -1.5
Arm fat percentage (left) 0.2 0.6 1.4 0.3 -0.6 -0.8 1.2
Average weekly red wine intake 0.2 0.3 0.8 -0.9 0.5 -0.1 -0.5
Handedness (chirality/laterality): Left-handed 0.7 0.8 1.5 1.0 1.2 0.2 0.8
Mood swings 0.9 1.5 3.1 1.7 0.1 -0.5 1.8
Loneliness, isolation 0.6 0.8 1.4 -1.2 -0.6 -0.7 1.0
Long-standing illness, disability or infirmity 0.1 0.2 0.7 -0.8 0.3 0.2 -0.0
Ever had bowel cancer screening 0.1 0.2 0.5 -0.2 -0.7 0.0 -0.2
Diabetes diagnosed by doctor 0.1 0.2 0.4 -0.6 -0.5 -0.2 0.3
Ever had stillbirth, spontaneous miscarriage or termination 3.8 4.1 7.1 0.2 -2.4 -2.7 -1.9
Friendships satisfaction 0.4 0.5 1.4 1.2 -0.2 0.1 0.9
Qualifications: nursing, teaching 0.4 0.6 1.7 -0.4 -1.3 -0.8 -0.2
Commuting to job workplace: Walk 0.2 0.2 0.4 0.1 -0.5 -0.6 0.4
Eye problems/disorders: Cataract 0.9 1.0 3.3 -1.8 -0.3 0.9 0.1
Mouth/teeth dental problems: Mouth ulcers 1.0 1.5 4.2 0.1 -2.1 -1.3 0.4
Medication for cholesterol 0.4 0.6 1.6 -0.4 -1.3 -0.5 -0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.7 -0.8 -0.1 0.7 -0.1
Back pain experienced in last month 0.6 0.9 1.7 -0.6 0.4 -1.2 -1.3
Mineral and other dietary supplements 0.3 0.4 0.8 0.5 -0.9 0.1 0.7
Breast cancer (self-reported) 0.1 0.1 0.3 0.5 0.2 0.4 -0.2
Asthma (self-reported) 0.3 0.5 1.6 0.3 0.7 -0.1 1.3
Osteoporosis (self-reported) 0.2 0.2 0.5 -0.4 -0.4 0.0 -0.7
Osteoarthritis (self-reported) 2.3 3.0 4.8 -1.2 -1.4 -1.9 -2.2
Medication: Aspirin 1.4 1.8 3.9 1.5 2.0 0.6 0.9
Medication: Gliclazide 0.3 0.3 0.7 -0.5 -0.1 0.5 0.9
Illnesses of father: None of the above (group 1) 2.0 2.5 3.8 -1.6 -2.0 -1.0 -1.6
Smoking status: Current 0.5 0.8 2.4 0.1 0.7 0.4 -1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.3 0.8 -0.9 -0.3 0.3 0.3
Whole body water mass 0.3 1.4 2.6 1.4 -0.4 -1.1 -1.6
Leg predicted mass (right) 0.3 1.6 2.5 0.5 -1.2 -1.6 -1.4
Arm fat mass (left) 0.2 0.6 1.2 1.0 -0.2 -1.1 0.4
Number of self-reported non-cancer illnesses 0.2 0.3 0.6 -0.0 0.8 0.6 0.6
Average weekly champagne plus white wine intake 0.3 0.4 0.7 0.4 0.6 0.8 0.7
Miserableness 0.6 1.0 1.2 0.6 -1.0 -1.1 1.1
Guilty feelings 0.8 1.2 2.7 -0.2 -1.6 -1.2 -0.6
Wears glasses or contact lenses 0.6 0.6 1.2 -1.1 -0.7 -0.8 0.5
Ever taken oral contraceptive pill 0.6 0.6 1.9 -0.4 -1.4 -0.7 -0.1
Hearing aid user 1.4 1.5 3.0 -0.4 1.7 1.1 1.3
Mother’s age at death 0.5 0.6 1.1 1.1 0.5 0.2 0.9
Financial situation satisfaction 0.4 0.4 1.3 1.2 0.5 0.2 0.4
Tinnitus: Yes, now most or all of the time 2.6 3.0 8.8 0.9 0.1 1.6 3.0
Commuting to job workplace: Public transport 2.4 2.9 6.0 -1.0 -1.6 -2.4 -1.4
Eye problems/disorders: Glaucoma 1.6 1.9 3.3 0.6 -1.4 -1.8 -1.5
Medication: Blood pressure 0.4 0.8 1.9 -0.6 -0.3 -1.4 -1.0
Pain type(s) experienced in last month: Hip pain 4.0 5.1 6.6 -2.4 -2.6 -2.0 -2.0
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.8 0.3 1.4 0.2 -0.4
High cholesterol (Self-reported) 6.2 10.9 16.6 1.9 4.1 3.7 3.1
Medication: Bendroflumethiazide 0.1 0.1 0.3 -0.1 0.5 0.2 -0.1
Medication: Paracetamol 0.1 0.1 0.2 0.1 0.0 0.5 0.5
Medication: Lisinopril 5.3 6.9 10.0 1.2 3.2 3.1 2.6
Medication: Atorvastatin 5.0 6.2 15.4 1.6 3.9 2.3 1.2
Illnesses of father: High blood pressure 1.3 1.6 2.8 -1.7 -1.0 -0.5 -1.5
Alcohol drinker status: Never 0.5 0.6 0.9 0.4 0.9 -0.9 -0.7
Ever smoked 0.4 0.7 1.5 1.2 -0.5 0.6 0.9
Basal metabolic rate 0.2 1.3 2.0 1.4 -0.3 -1.2 -1.3
Leg fat percentage (left) 0.5 1.8 3.8 1.9 1.2 0.2 1.3
Arm fat-free mass (left) 0.3 1.5 3.2 1.8 0.7 -0.6 -1.4
Number of operations (self-reported) 0.2 0.3 0.7 0.1 0.4 0.5 0.8
Average weekly beer plus cider intake 0.3 0.5 1.6 1.3 0.4 -0.4 0.2
Irritability 0.3 0.5 1.9 1.4 -0.2 0.1 -0.3
Risk taking 1.5 2.2 4.3 -0.7 -2.1 -1.5 -1.3
Ever had prostate specific antigen (PSA) test 0.5 0.6 1.2 -0.2 -1.0 0.0 1.1
Fractured/broken bones in last 5 years 0.4 0.5 1.5 -0.2 0.6 0.1 -1.2
Age started oral contraceptive pill 0.4 0.5 0.9 -0.8 -0.6 -0.9 -0.2
Diastolic blood pressure, automated reading 0.2 0.7 1.2 -1.1 0.1 0.8 1.0
Ever depressed for a whole week 0.3 0.4 0.9 0.7 -0.1 -0.9 -0.0
Unable to work because of sickness or disability 0.3 0.4 1.0 0.5 -0.4 0.1 1.0
Commuting to job workplace: Cycle 1.6 1.9 4.5 -1.7 -2.1 0.3 -0.4
Myopia 0.9 1.3 4.8 -0.5 -2.2 -0.3 0.1
Vascular/heart problems diagnosed by doctor 0.2 0.6 1.1 1.0 -0.4 -0.5 -1.0
Cholesterol lowering medication 0.7 1.1 4.3 0.0 2.1 0.3 0.0
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.3 0.1 0.2 1.0 1.2
Pain experienced in last month 0.4 0.7 2.4 0.3 0.4 1.5 0.2
Supplements: Calcium 1.2 1.4 2.9 -1.1 -0.0 -1.2 -1.7
Basal cell carcinoma (self-reported) 1.2 1.4 3.9 2.0 0.5 -0.8 0.8
Heart attack/myocardial infarction (self-reported) 1.0 1.3 3.4 1.1 1.8 0.2 -0.8
Deep venous thrombosis (DVT) (self-reported) 1.0 1.3 3.3 0.8 1.8 -0.1 -1.1
Heart disease (siblings) 0.3 0.4 0.9 0.1 0.9 -0.0 0.9
Alcohol drinker status: Previous 0.9 1.0 2.4 -0.8 -0.4 0.9 1.5
Pack years of smoking 1.0 1.5 4.5 2.1 0.7 -0.9 -0.0
Impedance of whole body 0.1 0.6 2.2 -1.5 -0.0 -0.4 0.3
Leg fat mass (left) 0.4 1.4 4.1 2.0 0.7 -0.2 0.9
Arm predicted mass (left) 0.3 1.7 4.0 2.0 0.7 -0.8 -1.3