Hub : Genes

TMEM255B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Frontal Cortex BA9	0.2291	0.1149	6.9e-03	0.084	NA	0.081	NA	0.134	3.0e-03	NA	3.6e-03	NA	2.1e-04
2	GTEx	Brain Hippocampus	0.2298	0.0996	5.0e-03	0.036	NA	0.050	NA	0.010	5.1e-02	NA	2.7e-02	NA	1.9e-01
3	GTEx	Cells Transformed fibroblasts	0.6080	0.0410	0.0e+00	0.496	NA	0.567	NA	0.530	4.1e-42	NA	5.4e-51	NA	3.6e-46
4	METSIM	Adipose	0.0866	0.0255	2.7e-07	0.022	0.054	0.066	0.057	0.051	2.6e-04	1.5e-08	4.1e-10	6.7e-09	3.6e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.5	0.8	1.4	1.2	0.7	-0.3	1.2
Bipolar Disorder or Schizophrenia	0.1	0.3	0.5	0.6	-0.0	-0.7	0.7
Depressed Affect (Nagel 2018)	0.2	0.3	0.5	0.2	-0.6	-0.7	0.7
Depression (Nagel 2018)	1.0	1.5	3.0	0.3	1.0	1.5	1.7
Intelligence (Savage-Jansen 2018)	1.1	3.3	7.4	-0.9	-2.7	-1.5	-1.7
Neuroticism (Nagel 2018)	0.3	0.8	1.9	0.8	-0.7	-1.4	-0.1
Schizophrenia (2018)	0.1	0.2	0.4	-0.2	-0.6	-0.6	-0.1
Schizophrenia vs Biploar Disorder	0.1	0.2	0.3	-0.2	0.5	0.6	0.1
Worry (Nagel 2018)	0.9	1.9	4.3	-0.2	-1.2	-2.1	-1.4
Alzheimer’s Disease (in mother)	0.2	0.2	0.5	-0.7	0.1	-0.5	-0.4
Alzheimer’s Disease (in father)	0.7	0.8	1.5	-1.2	0.4	-0.5	-1.1
Alzheimer’s Disease (including proxy)	0.3	0.5	0.7	-0.8	0.6	-0.5	-0.7
Crohns Disease (2017)	0.1	0.1	0.2	0.5	-0.1	-0.4	0.3
Irritable Bowel Disease (IBD)	0.1	0.2	0.5	-0.1	0.2	-0.7	-0.2
Ulcerative Colitis (UC)	0.1	0.3	0.5	-0.0	0.5	-0.7	-0.6
Major Depression (MDD)	0.2	0.2	0.8	0.0	0.0	-0.9	0.0
Reaction Time	0.2	0.4	1.1	-1.0	-0.1	-0.7	0.5
Verbal and Numeric Reasoning (VNR)	1.3	3.0	5.5	-0.6	-2.3	-1.9	-1.7
Breast Cancer	0.5	1.2	2.6	-1.6	-0.4	0.0	-1.4
Ovarian Cancer	0.3	0.4	0.6	0.7	-0.1	0.8	0.7
Prostate Cancer	0.8	1.1	3.5	0.8	-0.4	-0.2	1.9
Age at First Birth	0.3	0.4	0.6	0.4	0.5	-0.8	-0.7
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.7	1.0	2.2	-0.1	-0.1	-1.4	-1.5
Coronary Artery Disease (CAD)	0.4	0.5	1.6	-0.5	0.0	1.3	0.4
Crohns Disease (2012)	0.0	0.1	0.2	0.4	0.1	-0.0	0.3
Mean Putamen Volume	0.1	0.1	0.5	-0.7	0.3	-0.2	-0.0
Fasting Glucose	0.1	0.1	0.2	-0.4	-0.2	0.4	-0.4
HbA1C	3.6	4.0	7.6	2.1	2.8	1.0	1.7
HDL Cholesterol	0.3	0.4	0.9	-0.7	-1.0	-0.4	-0.3
LDL Cholesterol	2.0	3.1	4.5	-0.9	1.8	2.0	2.1
Lupus	0.1	0.2	0.3	-0.6	-0.1	0.0	0.5
Neuroticism (2016)	0.2	0.3	1.0	-0.2	-0.4	-1.0	-0.0
Primary Biliary Cirrhosis	0.6	0.9	1.6	0.7	1.1	-1.3	-0.6
Rheumatoid Arthritis	1.4	2.0	6.8	0.2	-0.5	-2.6	-0.9
Schizophrenia (2014)	0.1	0.3	0.5	0.2	-0.6	-0.4	0.7
Triglycerides	0.7	1.2	3.2	1.0	0.8	0.3	1.8
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.3	-0.8	0.0	0.5	1.5
Ulcerative Colitis	2.2	3.1	6.9	1.7	2.6	0.9	1.4
Blood Eosinophil Count	0.3	1.9	5.3	-1.0	1.2	-2.3	-0.4
Blood Platelet Count	0.4	4.3	6.6	2.4	1.8	-2.6	-1.1
Blood Red Count	3.1	30.3	37.7	5.1	4.8	6.1	5.8
Blood White Count	2.5	18.9	35.5	3.0	6.0	3.9	4.0
Heel T-Score	0.2	1.3	2.5	-0.4	-0.9	-1.2	-1.6
BMI	0.3	2.0	4.4	0.6	-2.1	-1.7	-0.1
Height	0.4	7.6	16.2	-0.5	-1.8	-3.2	-4.0
Waist Hip Ratio (WHR)	2.4	10.8	16.1	3.4	3.0	2.6	4.0
Systolic Blood Pressure	1.7	8.6	11.4	2.6	2.7	3.0	3.4
Smoking Status	0.2	0.5	0.6	0.7	-0.6	-0.7	-0.8
Allergy or Eczema	0.9	2.3	4.7	-0.2	-2.1	-2.2	-0.2
Cardiovascular Disease	0.8	2.6	6.4	-1.2	0.8	1.3	2.5
Hypothyroidism (self reported)	0.2	0.6	1.6	-0.6	-1.3	-0.2	-0.4
Respiratory disease	0.2	0.4	1.6	-0.1	0.3	0.1	1.3
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.6	-0.3	-0.8	-0.0	0.0
Lung FEV1/FVC ratio	0.7	3.4	6.2	0.7	1.9	2.5	1.8
Lung FVC	0.1	0.4	1.0	-0.5	0.5	-0.4	-1.0
Neuroticism	0.2	0.5	1.2	0.3	-1.1	-0.8	0.3
Chronotype (morning person)	0.3	0.6	1.5	1.2	0.7	0.2	-0.6
Hair Pigment	0.0	0.8	2.4	0.6	-0.1	-0.6	1.6
Tanning	0.1	1.4	2.8	1.7	0.9	0.7	1.3
Hand grip strength (left)	1.0	2.6	3.7	1.9	1.6	1.8	1.0
Number of treatments/medications taken	1.4	2.5	4.5	0.9	1.2	2.1	1.9
Average weekly spirits intake	0.3	0.4	0.7	-0.2	0.5	0.7	0.9
Sensitivity / hurt feelings	0.3	0.5	0.7	0.8	-0.8	-0.8	0.3
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.8	-1.3	-0.6	-0.4	0.2
Hearing difficulty/problems: Yes	0.4	0.6	1.7	1.3	0.5	-0.2	0.5
Relative age of first facial hair	0.2	0.4	1.2	0.2	0.4	-1.1	0.3
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.2	0.7	0.5	0.0	1.1
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.5	-0.5	-0.1	-1.2	1.0
Ever had hysterectomy (womb removed)	0.4	0.4	0.8	0.8	0.9	0.4	0.1
Systolic blood pressure, automated reading	0.8	2.4	3.1	1.5	1.4	1.4	1.8
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	3.2	-1.8	-0.2	1.4	0.7
Angina	0.6	0.8	2.2	-0.8	1.5	0.3	-0.5
Medication for hormone replacement therapy	0.5	0.6	1.5	0.6	0.1	0.7	1.2
Vitamin and mineral supplements	2.7	3.7	5.2	2.3	2.1	1.8	1.5
Supplements: Zinc	2.0	2.1	4.0	-1.4	-0.5	-1.6	-2.0
Medication: Co-codamol	0.2	0.3	0.8	0.2	-0.4	-0.9	-0.3
Medication: Metformin	0.9	1.2	1.9	0.6	0.9	1.4	1.3
Diabetes (father)	1.2	1.5	2.7	1.7	1.5	-0.0	1.0
Diabetes (mother)	0.1	0.2	0.3	-0.2	-0.6	-0.5	-0.3
Severe depression (siblings)	1.0	1.2	3.5	-0.6	-1.9	-0.2	-0.9
Pack years adult smoking proportion	1.1	1.6	5.4	2.3	0.9	-0.6	-0.1
Impedance of leg (right)	0.2	1.0	2.1	0.6	1.5	0.9	0.7
Leg fat-free mass (left)	0.3	1.5	2.5	0.5	-1.1	-1.6	-1.4
Trunk fat percentage	0.2	0.6	1.2	0.6	-0.2	-1.1	1.0
Hand grip strength (right)	0.3	0.8	1.9	1.0	0.4	1.4	0.2
Townsend deprivation index at recruitment	1.0	1.4	2.4	-1.0	-1.5	-1.4	-0.7
Current tobacco smoking	0.4	0.7	2.4	-0.1	0.4	0.2	-1.6
Average weekly fortified wine intake	0.9	1.1	2.4	-0.0	0.3	1.4	1.6
Maternal smoking around birth	0.3	0.4	1.0	-0.8	0.3	0.1	-1.0
Fed-up feelings	0.5	0.9	2.5	0.5	-0.9	-0.2	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	2.3	0.2	-0.0	0.4	1.5
Relative age voice broke	0.6	0.9	1.9	0.9	0.4	-0.9	1.4
Taking other prescription medications	0.7	1.0	2.4	-0.1	0.5	1.5	1.2
Age when periods started (menarche)	0.2	0.4	0.7	0.8	0.3	0.7	0.7
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	0.8	-0.9	-0.4	-0.7	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	1.7	-0.8	-1.1	-1.3	-0.4
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.8	0.5	-0.3	-0.9	0.4
Qualifications: CSEs or equivalent	0.1	0.1	0.1	0.3	0.3	0.3	0.3
Serious illness, injury or assault to yourself	0.6	0.7	1.6	-0.4	-0.2	1.0	1.3
High blood pressure	0.2	0.5	1.3	-1.1	-0.0	0.0	0.9
Hayfever, allergic rhinitis or eczema	0.6	1.2	3.1	-0.3	-1.8	-1.3	-0.3
Multivitamins +/- minerals	3.1	4.0	6.7	-1.6	-2.6	-2.3	-1.2
Stomach or abdominal pain in last month	0.3	0.4	1.0	-1.0	-0.6	-0.1	-0.5
Supplements: Glucosamine	0.5	0.6	1.3	0.2	1.1	1.1	-0.1
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	2.0	1.3	-1.0	-1.4	0.8
Medication: Atenolol	0.3	0.3	1.0	0.1	1.0	-0.1	-0.5
Medication: Levothyroxine sodium	0.6	0.9	2.2	0.9	0.6	1.5	0.6
Sitting height	0.1	0.6	2.1	0.2	0.3	0.2	-1.4
Chronic bronchitis/emphysema (father)	0.8	1.0	1.5	-1.1	-0.3	-1.2	-1.1
High blood pressure (mother)	0.7	1.0	2.0	0.7	0.8	1.0	1.4
Body mass index (BMI)	0.2	1.0	2.6	1.6	0.2	-0.4	1.0
Impedance of leg (left)	0.2	0.9	2.6	0.7	1.6	0.6	0.5
Leg predicted mass (left)	0.3	1.6	2.5	0.5	-1.2	-1.6	-1.5
Trunk fat mass	0.2	0.7	1.3	1.1	-0.1	-1.0	0.6
Waist circumference	0.6	2.2	5.9	2.4	0.5	-0.3	1.6
Number of incorrect matches in round	1.7	2.9	3.8	1.9	1.9	1.9	0.8
Past tobacco smoking	0.2	0.4	1.2	-0.5	1.1	0.4	-0.3
Alcohol usually taken with meals	0.5	0.9	2.2	-1.5	0.1	1.1	0.2
Nervous feelings	0.2	0.4	1.5	-0.2	-0.3	-1.2	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	1.8	-0.6	-1.3	-1.3	-0.6
Hearing difficulty/problems with background noise	1.5	2.4	4.4	-1.2	-2.1	-1.6	-1.1
Hair/balding pattern: Pattern 2	0.3	0.4	1.3	0.1	1.1	0.0	-0.5
Had menopause	0.5	0.6	1.2	0.4	-0.3	-1.0	1.1
Had other major operations	1.3	1.6	3.9	0.6	0.8	1.1	2.0
Forced vital capacity (FVC)	0.5	2.1	5.1	-0.9	-0.9	-1.2	-2.3
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.1	0.1	-0.6	-1.1	-0.1
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.5	1.6	-0.2	0.3	1.3
Qualifications: None of the above	0.8	1.8	6.9	0.3	2.6	0.4	0.3
Financial difficulties in last 2 years	1.2	1.6	2.3	-1.2	-1.0	-1.5	-1.3
Mouth/teeth dental problems	0.5	0.7	1.8	0.8	1.3	0.7	0.0
Heart attack	1.0	1.3	3.8	0.9	1.9	0.3	-0.8
Allergy	0.2	0.4	0.8	-0.6	0.4	0.7	-0.9
Pain all over the body in last month	0.9	0.9	2.3	1.0	0.6	-1.5	-0.4
Diabetes (self-reported)	0.1	0.2	0.4	-0.5	-0.6	0.1	0.4
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	1.6	-1.3	-1.3	-1.2	-0.7
Medication: Ramipril	0.9	1.2	2.3	0.2	0.8	1.5	1.3
Medication: Simvastatin	1.8	2.6	4.6	1.5	2.1	1.6	1.2
Fluid intelligence score	3.0	6.2	10.7	-0.8	-3.3	-2.7	-2.5
Illnesses of siblings	0.4	0.6	1.0	0.0	-0.9	1.0	-0.8
Neuroticism score	0.5	1.1	2.2	0.1	-1.5	-1.4	0.1
Weight	0.2	1.0	2.4	1.5	-0.2	-1.2	-0.3
Impedance of arm (right)	0.4	2.0	4.4	-2.1	-1.4	-1.2	0.1
Arm fat percentage (right)	0.2	0.6	1.5	0.6	-0.3	-0.8	1.2
Trunk fat-free mass	0.2	1.3	3.6	1.9	0.1	-0.4	-1.2
Hip circumference	0.6	2.6	6.5	0.3	-1.7	-2.5	-0.9
Time employed in main current job	0.5	0.6	1.2	-0.1	-0.7	-1.1	-0.8
Alcohol intake versus 10 years previously	0.3	0.4	1.1	0.6	-0.2	-0.6	-1.0
Father’s age at death	0.9	1.2	2.4	-1.2	-1.6	-1.0	0.3
Worrier / anxious feelings	0.6	1.1	2.5	-0.2	-0.9	-1.6	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.3	0.8	-0.8	-0.9	1.1
Falls in the last year	0.5	0.7	1.4	0.9	0.7	-1.2	-0.3
Hair/balding pattern: Pattern 3	0.2	0.4	1.0	0.1	-0.6	-1.0	0.3
Number of live births	0.5	0.7	1.4	0.7	1.2	0.6	-0.7
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	2.3	-0.7	-0.4	-0.4	-1.5
Pulse rate	2.6	4.4	8.0	2.4	2.8	1.5	1.3
Happiness	1.7	2.1	4.3	1.9	-0.1	0.8	2.1
Noisy workplace	0.5	0.6	1.2	-0.1	-0.7	-1.1	-0.8
Qualifications: A levels/AS levels or equivalent	1.3	2.8	8.6	-1.1	-2.9	-0.9	-0.8
Serious illness, injury or assault of a close relative in last 2 years	2.3	2.6	5.9	0.0	0.9	2.4	2.0
Mouth/teeth dental problems: Dentures	0.3	0.4	0.7	-0.6	0.8	0.5	-0.6
Asthma	0.2	0.4	1.4	0.2	0.4	-0.2	1.2
Medication: Ibuprofen (e.g. Nurofen)	3.1	4.0	8.6	0.3	1.2	2.4	2.9
Medication: Cholesterol lowering	5.9	9.1	13.7	1.8	3.4	3.7	2.8
Depression (self-reported)	0.6	0.7	1.7	1.0	-0.1	0.5	1.3
Medication: Lansoprazole	2.4	2.7	3.9	1.2	1.5	1.8	2.0
Prospective memory result	2.3	2.8	6.0	1.2	1.4	1.3	2.5
Lung cancer (father)	2.3	2.7	4.5	-1.6	-2.1	-0.6	-1.8
Illnesses of mother	0.6	0.7	1.1	-1.1	-0.1	-0.7	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.2	-0.2	0.9	1.1	-0.7
Pulse wave Arterial Stiffness index	0.2	0.3	1.0	-0.3	0.2	0.3	-1.0
Impedance of arm (left)	0.7	3.0	7.6	-2.8	-1.8	-1.1	-0.1
Arm fat mass (right)	0.2	0.7	1.9	1.4	0.1	-0.8	0.6
Trunk predicted mass	0.2	1.3	3.2	1.8	0.0	-0.4	-1.3
Standing height	0.3	2.8	7.4	0.1	-0.8	-1.7	-2.7
Length of working week for main job	2.1	2.3	4.8	-0.3	-1.7	-2.2	-1.1
Exposure to tobacco smoke at home	0.6	0.6	1.4	0.5	1.2	-0.9	-0.5
Breastfed as a baby	0.3	0.4	0.9	1.0	0.3	-0.3	-0.7
Tense / ‘highly strung’	1.6	2.7	6.0	-0.2	-1.4	-2.5	-1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	2.5	-0.8	-1.5	-1.6	-0.3
Hair/balding pattern: Pattern 4	0.3	0.7	1.4	-1.2	-1.0	0.5	-0.5
Birth weight of first child	0.7	1.3	2.3	-1.5	-1.3	-0.7	-0.7
Peak expiratory flow (PEF)	0.2	0.6	1.3	0.4	0.3	-0.9	-1.1
Pulse wave reflection index	2.6	3.2	6.3	-1.4	-2.5	-1.8	-1.2
Ever highly irritable/argumentative for 2 days	1.7	2.1	4.7	0.9	-2.2	-1.7	0.1
Loud music exposure frequency	0.8	0.8	2.0	0.7	1.4	0.8	-0.2
Qualifications: O levels/GCSEs or equivalent	2.0	3.2	4.7	-1.3	-2.2	-2.1	-1.4
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.8	0.3	-0.9	0.0	0.3
Blood clot in the leg (DVT)	1.0	1.2	3.7	0.8	1.9	0.1	-0.7
Medication: Paracetamol	0.3	0.5	0.7	0.8	0.4	0.6	0.8
Headache pain in last month	0.4	0.6	1.2	0.2	0.6	1.1	0.9
Medication for cholesterol, blood pressure or diabetes	5.9	9.8	15.1	-1.7	-2.7	-3.8	-3.9
Glaucoma (self-reported)	0.9	1.1	1.5	0.8	-1.2	-1.1	-0.9
Gout (self-reported)	0.6	0.8	1.8	-0.0	1.4	1.1	-0.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.3	0.2	0.4	1.1	0.6
Medication: Amlodipine	0.2	0.3	1.1	0.1	-0.2	0.5	1.0
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.6	-1.0	-1.3	-0.6	0.2
Birth weight	1.0	2.1	3.0	-1.1	-1.6	-1.2	-1.7
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.0	-1.0	-0.6	-0.4	-0.7
High blood pressure (siblings)	0.5	0.7	1.5	0.6	0.4	-1.2	0.8
Forced vital capacity (FVC), Best measure	0.2	0.7	2.2	-0.7	0.2	0.4	-1.5
Body fat percentage	0.2	0.8	1.8	1.1	0.1	-0.6	1.4
Leg fat percentage (right)	0.5	1.9	4.1	2.0	1.2	0.4	1.5
Arm fat-free mass (right)	0.3	1.5	3.5	1.9	0.4	-0.6	-1.3
Exposure to tobacco smoke outside home	0.5	0.6	1.8	-0.2	1.3	0.8	0.2
Comparative body size at age 10	0.0	0.1	0.3	-0.3	0.2	0.2	-0.5
Number of full brothers	0.8	1.1	2.1	1.4	-0.3	-1.4	-0.2
Worry too long after embarrassment	1.8	2.9	5.6	0.3	-1.7	-2.4	-1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.6	0.7	-0.8	-0.1	0.3
Wheeze or whistling in the chest in last year	0.0	0.0	0.1	0.1	-0.1	0.1	0.4
Number of children fathered	0.7	0.8	2.7	0.2	-0.1	-0.5	1.7
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.7	-0.2	0.1	0.8	0.6
Age at first live birth	0.1	0.1	0.3	0.6	-0.1	0.0	0.5
Pulse wave peak to peak time	0.2	0.2	0.6	0.2	-0.3	-0.4	0.8
Health satisfaction	0.8	1.0	3.3	0.7	-0.1	0.4	1.8
Shortness of breath walking on level ground	0.1	0.1	0.3	-0.6	0.1	-0.1	0.1
Qualifications: College or University degree	0.5	1.6	5.4	-0.3	-2.3	-0.2	-0.8
Eye problems/disorders: None of the above	0.4	0.5	1.3	1.1	0.7	-0.3	0.1
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.8	-0.2	-0.9	-0.5	-0.1
Emphysema/chronic bronchitis	1.6	1.8	2.4	-1.6	-0.4	-1.5	-1.5
Medication for pain relief, constipation, heartburn	2.1	3.5	4.7	-1.1	-2.2	-2.0	-2.1
Neck or shoulder pain in last month	0.2	0.3	0.7	-0.9	0.4	0.1	0.6
Medication: Blood pressure	2.7	4.7	9.1	0.7	1.4	2.7	3.0
Angina (self-reported)	0.5	0.7	1.5	-0.9	1.2	0.0	-0.6
Migraine (self-reported)	0.5	0.6	1.7	0.3	1.3	-0.5	-0.6
Medication: Ibuprofen	3.0	3.5	7.7	0.3	1.3	2.1	2.8
Medication: Allopurinol	0.4	0.6	1.4	0.1	1.2	0.9	0.3
Medication: Omeprazole	0.1	0.1	0.2	-0.3	-0.0	0.2	0.4
Medication: Seretide 50 evohaler	2.0	2.3	3.7	-1.9	-1.5	-1.1	-1.4
Mean time to correctly identify matches	0.2	0.4	1.3	-0.3	0.0	0.0	1.2
Heart disease (mother)	0.7	0.9	2.8	-0.4	-1.7	-0.1	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	1.6	1.0	1.3	1.2	1.1
Whole body fat mass	0.2	0.9	2.4	1.6	0.2	-0.8	0.7
Leg fat mass (right)	0.3	1.3	4.0	2.0	0.6	-0.1	1.0
Arm predicted mass (right)	0.3	1.3	2.9	1.7	0.4	-0.5	-1.4
Pulse rate, automated reading	2.6	8.3	14.3	2.8	3.8	1.7	2.8
Alcohol intake frequency.	0.2	0.4	0.8	-0.9	0.1	-0.3	-0.8
Comparative height size at age 10	0.3	1.9	5.7	-0.4	-0.8	-1.1	-2.4
Number of full sisters	0.3	0.3	0.7	0.9	0.6	0.5	0.0
Suffer from ‘nerves’	0.6	0.9	2.3	-0.7	-0.7	-1.5	-0.7
Overall health rating	0.2	0.5	1.2	-0.0	0.9	0.0	1.1
Chest pain or discomfort	0.2	0.3	0.6	-0.5	0.7	0.3	0.8
Had major operations	1.4	1.7	3.4	1.2	0.1	1.3	1.8
Age at last live birth	1.2	1.8	2.7	0.1	-1.6	-1.7	-1.4
Family relationship satisfaction	1.8	2.3	6.9	0.6	-0.9	1.0	2.6
Leg pain on walking	1.7	2.1	3.5	-0.4	-1.9	-1.8	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.1	0.1	0.3	0.3	0.1	0.3
Commuting to job workplace: Car/motor vehicle	1.9	2.2	3.4	1.8	1.3	1.6	1.1
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.5	1.6	1.2	-0.6	0.4
Medication: Aspirin	1.3	1.8	5.5	1.0	2.3	0.6	0.5
Supplements: Vitamin C	2.1	2.5	4.7	-2.2	-1.3	-0.6	-1.8
Knee pain experienced in last month	1.0	1.6	3.6	-0.6	-0.9	-1.9	-1.3
Hypertension (Self-reported)	0.2	0.5	1.1	-1.1	0.2	0.1	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	1.5	0.4	1.2	1.0	0.9
Illnesses of father: Heart disease	1.3	1.8	3.6	0.4	0.5	1.9	1.8
Illnesses of siblings: Diabetes	0.9	1.1	2.7	1.1	1.6	0.1	0.5
Smoking status: Previous	0.6	0.9	2.1	0.3	-1.5	-1.2	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	2.9	-1.0	-1.7	-0.6	-0.9
Whole body fat-free mass	0.2	1.3	2.1	1.5	-0.4	-1.0	-1.4
Leg fat-free mass (right)	0.3	1.7	2.7	0.6	-1.2	-1.6	-1.5
Arm fat percentage (left)	0.2	0.6	1.4	0.3	-0.6	-0.8	1.2
Average weekly red wine intake	0.2	0.3	0.8	-0.9	0.5	-0.1	-0.5
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.5	1.0	1.2	0.2	0.8
Mood swings	0.9	1.5	3.1	1.7	0.1	-0.5	1.8
Loneliness, isolation	0.6	0.8	1.4	-1.2	-0.6	-0.7	1.0
Long-standing illness, disability or infirmity	0.1	0.2	0.7	-0.8	0.3	0.2	-0.0
Ever had bowel cancer screening	0.1	0.2	0.5	-0.2	-0.7	0.0	-0.2
Diabetes diagnosed by doctor	0.1	0.2	0.4	-0.6	-0.5	-0.2	0.3
Ever had stillbirth, spontaneous miscarriage or termination	3.8	4.1	7.1	0.2	-2.4	-2.7	-1.9
Friendships satisfaction	0.4	0.5	1.4	1.2	-0.2	0.1	0.9
Qualifications: nursing, teaching	0.4	0.6	1.7	-0.4	-1.3	-0.8	-0.2
Commuting to job workplace: Walk	0.2	0.2	0.4	0.1	-0.5	-0.6	0.4
Eye problems/disorders: Cataract	0.9	1.0	3.3	-1.8	-0.3	0.9	0.1
Mouth/teeth dental problems: Mouth ulcers	1.0	1.5	4.2	0.1	-2.1	-1.3	0.4
Medication for cholesterol	0.4	0.6	1.6	-0.4	-1.3	-0.5	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.7	-0.8	-0.1	0.7	-0.1
Back pain experienced in last month	0.6	0.9	1.7	-0.6	0.4	-1.2	-1.3
Mineral and other dietary supplements	0.3	0.4	0.8	0.5	-0.9	0.1	0.7
Breast cancer (self-reported)	0.1	0.1	0.3	0.5	0.2	0.4	-0.2
Asthma (self-reported)	0.3	0.5	1.6	0.3	0.7	-0.1	1.3
Osteoporosis (self-reported)	0.2	0.2	0.5	-0.4	-0.4	0.0	-0.7
Osteoarthritis (self-reported)	2.3	3.0	4.8	-1.2	-1.4	-1.9	-2.2
Medication: Aspirin	1.4	1.8	3.9	1.5	2.0	0.6	0.9
Medication: Gliclazide	0.3	0.3	0.7	-0.5	-0.1	0.5	0.9
Illnesses of father: None of the above (group 1)	2.0	2.5	3.8	-1.6	-2.0	-1.0	-1.6
Smoking status: Current	0.5	0.8	2.4	0.1	0.7	0.4	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.8	-0.9	-0.3	0.3	0.3
Whole body water mass	0.3	1.4	2.6	1.4	-0.4	-1.1	-1.6
Leg predicted mass (right)	0.3	1.6	2.5	0.5	-1.2	-1.6	-1.4
Arm fat mass (left)	0.2	0.6	1.2	1.0	-0.2	-1.1	0.4
Number of self-reported non-cancer illnesses	0.2	0.3	0.6	-0.0	0.8	0.6	0.6
Average weekly champagne plus white wine intake	0.3	0.4	0.7	0.4	0.6	0.8	0.7
Miserableness	0.6	1.0	1.2	0.6	-1.0	-1.1	1.1
Guilty feelings	0.8	1.2	2.7	-0.2	-1.6	-1.2	-0.6
Wears glasses or contact lenses	0.6	0.6	1.2	-1.1	-0.7	-0.8	0.5
Ever taken oral contraceptive pill	0.6	0.6	1.9	-0.4	-1.4	-0.7	-0.1
Hearing aid user	1.4	1.5	3.0	-0.4	1.7	1.1	1.3
Mother’s age at death	0.5	0.6	1.1	1.1	0.5	0.2	0.9
Financial situation satisfaction	0.4	0.4	1.3	1.2	0.5	0.2	0.4
Tinnitus: Yes, now most or all of the time	2.6	3.0	8.8	0.9	0.1	1.6	3.0
Commuting to job workplace: Public transport	2.4	2.9	6.0	-1.0	-1.6	-2.4	-1.4
Eye problems/disorders: Glaucoma	1.6	1.9	3.3	0.6	-1.4	-1.8	-1.5
Medication: Blood pressure	0.4	0.8	1.9	-0.6	-0.3	-1.4	-1.0
Pain type(s) experienced in last month: Hip pain	4.0	5.1	6.6	-2.4	-2.6	-2.0	-2.0
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.8	0.3	1.4	0.2	-0.4
High cholesterol (Self-reported)	6.2	10.9	16.6	1.9	4.1	3.7	3.1
Medication: Bendroflumethiazide	0.1	0.1	0.3	-0.1	0.5	0.2	-0.1
Medication: Paracetamol	0.1	0.1	0.2	0.1	0.0	0.5	0.5
Medication: Lisinopril	5.3	6.9	10.0	1.2	3.2	3.1	2.6
Medication: Atorvastatin	5.0	6.2	15.4	1.6	3.9	2.3	1.2
Illnesses of father: High blood pressure	1.3	1.6	2.8	-1.7	-1.0	-0.5	-1.5
Alcohol drinker status: Never	0.5	0.6	0.9	0.4	0.9	-0.9	-0.7
Ever smoked	0.4	0.7	1.5	1.2	-0.5	0.6	0.9
Basal metabolic rate	0.2	1.3	2.0	1.4	-0.3	-1.2	-1.3
Leg fat percentage (left)	0.5	1.8	3.8	1.9	1.2	0.2	1.3
Arm fat-free mass (left)	0.3	1.5	3.2	1.8	0.7	-0.6	-1.4
Number of operations (self-reported)	0.2	0.3	0.7	0.1	0.4	0.5	0.8
Average weekly beer plus cider intake	0.3	0.5	1.6	1.3	0.4	-0.4	0.2
Irritability	0.3	0.5	1.9	1.4	-0.2	0.1	-0.3
Risk taking	1.5	2.2	4.3	-0.7	-2.1	-1.5	-1.3
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.2	-0.2	-1.0	0.0	1.1
Fractured/broken bones in last 5 years	0.4	0.5	1.5	-0.2	0.6	0.1	-1.2
Age started oral contraceptive pill	0.4	0.5	0.9	-0.8	-0.6	-0.9	-0.2
Diastolic blood pressure, automated reading	0.2	0.7	1.2	-1.1	0.1	0.8	1.0
Ever depressed for a whole week	0.3	0.4	0.9	0.7	-0.1	-0.9	-0.0
Unable to work because of sickness or disability	0.3	0.4	1.0	0.5	-0.4	0.1	1.0
Commuting to job workplace: Cycle	1.6	1.9	4.5	-1.7	-2.1	0.3	-0.4
Myopia	0.9	1.3	4.8	-0.5	-2.2	-0.3	0.1
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.1	1.0	-0.4	-0.5	-1.0
Cholesterol lowering medication	0.7	1.1	4.3	0.0	2.1	0.3	0.0
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.3	0.1	0.2	1.0	1.2
Pain experienced in last month	0.4	0.7	2.4	0.3	0.4	1.5	0.2
Supplements: Calcium	1.2	1.4	2.9	-1.1	-0.0	-1.2	-1.7
Basal cell carcinoma (self-reported)	1.2	1.4	3.9	2.0	0.5	-0.8	0.8
Heart attack/myocardial infarction (self-reported)	1.0	1.3	3.4	1.1	1.8	0.2	-0.8
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	3.3	0.8	1.8	-0.1	-1.1
Heart disease (siblings)	0.3	0.4	0.9	0.1	0.9	-0.0	0.9
Alcohol drinker status: Previous	0.9	1.0	2.4	-0.8	-0.4	0.9	1.5
Pack years of smoking	1.0	1.5	4.5	2.1	0.7	-0.9	-0.0
Impedance of whole body	0.1	0.6	2.2	-1.5	-0.0	-0.4	0.3
Leg fat mass (left)	0.4	1.4	4.1	2.0	0.7	-0.2	0.9
Arm predicted mass (left)	0.3	1.7	4.0	2.0	0.7	-0.8	-1.3