TWAS hub - ADPRHL1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1480	0.0350	1.6e-08	0.116	0.080	0.076	0.102	0.103	5.8e-14	5.9e-10	1.7e-09	2.0e-12	1.7e-12
2	GTEx	Brain Caudate basal ganglia	0.1520	0.0670	7.4e-03	0.004	NA	0.029	NA	0.001	2.3e-01	NA	5.1e-02	NA	3.0e-01
3	METSIM	Adipose	0.0706	0.0301	2.8e-03	0.001	0.007	0.018	0.020	0.003	1.8e-01	2.5e-02	8.0e-04	4.6e-04	1.1e-01
4	TCGA	Glioblastoma Multiforme	0.2300	0.0820	1.1e-04	0.095	0.109	0.027	NA	0.071	8.0e-04	3.4e-04	5.1e-02	NA	3.4e-03
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0383	0.0176	2.9e-04	0.041	0.027	0.021	NA	0.030	1.9e-05	4.9e-04	1.8e-03	NA	2.0e-04
6	TCGA	Brain Lower Grade Glioma	0.0617	0.0285	2.0e-04	0.031	0.038	0.029	NA	0.032	1.9e-04	3.1e-05	2.7e-04	NA	1.4e-04
7	TCGA	Thyroid Carcinoma	0.0340	0.0180	5.2e-03	0.031	0.029	0.023	NA	0.027	5.0e-04	6.9e-04	2.4e-03	NA	1.2e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Supplements: Zinc	6.0	6.5	11.9	-2.1	2.6	-0.6	2.9	2.1	3.0	3.4
Multivitamins +/- minerals	3.5	4.5	8.8	-0.5	1.1	1.7	2.6	2.0	3.0	2.7
Family relationship satisfaction	3.4	4.2	8.5	-2.4	-2.7	-1.1	-1.7	-1.4	-2.9	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	3.4	3.6	8.9	-0.4	1.9	-0.7	3.0	3.0	0.6	1.7
Hair/balding pattern: Pattern 2	3.2	4.1	7.4	-0.2	-0.7	1.4	-2.5	-2.7	-2.3	-2.7
Medication: Seretide 50 evohaler	2.9	3.3	7.8	1.8	1.6	1.0	1.9	1.6	2.8	1.5
Knee pain experienced in last month	2.8	4.3	8.0	-0.3	2.0	-1.0	2.8	1.7	2.6	2.7
Hair/balding pattern: Pattern 3	2.6	3.8	8.5	0.3	1.3	0.5	2.6	2.9	1.9	2.4
Reaction Time	2.5	4.8	10.9	-1.3	3.3	-0.3	2.1	2.0	2.5	2.6
Vitamin and mineral supplements	2.5	3.3	7.8	0.3	-0.6	-1.6	-2.1	-1.4	-2.8	-2.5
Medication: Paracetamol	2.5	4.1	9.6	-0.5	0.6	-1.3	3.1	2.8	1.8	2.4
Type 2 Diabetes (T2D) (2012)	2.3	2.6	5.2	1.3	-0.4	1.0	-2.3	-1.3	-2.0	-2.2
Medication: Metformin	2.3	3.3	5.8	-0.1	-1.5	-1.5	-2.4	-1.9	-1.9	-2.4
Diabetes (self-reported)	2.3	3.6	7.4	-0.3	-1.4	-0.4	-2.7	-1.4	-2.5	-2.6
Qualifications: nursing, teaching	2.3	3.6	9.1	-0.5	-3.0	-1.2	-1.8	-2.3	-1.9	-1.4
Alzheimer’s Disease (in mother)	2.2	2.6	6.4	-0.9	2.5	2.0	1.6	1.0	1.1	1.4
Verbal and Numeric Reasoning (VNR)	2.1	5.0	12.0	-0.8	2.3	0.2	3.0	2.0	2.2	3.5
Tinnitus: Yes, now most or all of the time	2.1	2.5	6.8	-0.9	0.4	-0.2	-2.6	-1.4	-2.4	-1.4
High cholesterol (Self-reported)	2.1	3.8	6.4	1.2	-1.4	-2.5	-2.0	-2.4	-2.0	-1.6
Myopia	2.1	3.0	6.7	-0.7	-1.9	-0.5	-2.2	-1.0	-2.6	-2.0
Medication: Ramipril	2.0	2.5	5.0	-0.5	-1.2	-0.3	-2.0	-2.2	-2.1	-1.6
Exposure to tobacco smoke at home	2.0	2.2	7.7	0.8	2.8	-0.4	1.2	0.3	1.7	1.6
Birth weight	2.0	4.3	7.1	-0.3	1.8	1.5	2.5	2.4	2.4	2.7
Medication: Paracetamol	2.0	3.0	7.8	-0.7	0.4	-0.5	2.8	2.3	1.3	2.4
Rheumatoid Arthritis	1.9	2.6	8.0	1.0	2.8	0.2	1.4	1.4	2.0	1.2
Gout (self-reported)	1.9	2.6	4.1	-0.2	-1.6	-1.9	-2.0	-2.0	-1.4	-1.6
Comparative body size at age 10	1.9	5.3	14.4	3.8	-2.2	-1.1	-2.1	-1.5	-1.3	-2.9
Blood White Count	1.8	13.3	32.1	2.5	-0.4	5.7	-3.5	-3.7	-3.3	-4.3
Hearing difficulty/problems: Yes	1.8	2.8	10.9	2.0	0.3	-3.3	-1.0	0.3	-1.3	-1.2
Bilateral oophorectomy (both ovaries removed)	1.8	2.1	5.3	-1.1	1.1	0.4	2.1	1.5	0.4	2.3
Medication: Omeprazole	1.8	2.2	10.9	-3.3	1.0	1.1	0.8	0.7	-0.3	1.0
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	3.8	2.0	-1.7	-1.4	-1.4	0.0	-1.1	-1.9
Medication: Gliclazide	1.8	2.0	3.6	0.5	-1.9	-1.3	-1.3	-1.1	-1.5	-1.9
Medication: Atorvastatin	1.8	2.3	6.6	-0.0	-0.2	0.3	-1.8	-2.6	-1.7	-1.7
Fluid intelligence score	1.7	3.5	8.9	-0.5	1.8	0.3	2.4	1.5	2.0	3.0
Hearing difficulty/problems with background noise	1.6	2.6	10.4	0.5	1.5	-3.2	0.9	1.8	0.1	1.2
Medication: Cholesterol lowering	1.6	2.6	5.3	-0.5	0.2	0.4	-2.0	-2.1	-2.3	-1.9
Birth weight of first child	1.6	3.0	7.6	-0.3	1.4	0.5	1.9	2.0	2.8	1.9
Chronic bronchitis/emphysema (mother)	1.6	1.9	4.4	0.4	1.5	0.7	1.6	0.9	2.1	1.4
Number of full brothers	1.6	2.0	3.8	0.9	1.9	0.4	1.8	1.5	1.8	0.8
Pack years of smoking	1.6	2.3	9.9	0.8	3.1	1.2	0.9	1.3	1.1	0.2
Alzheimer’s Disease (including proxy)	1.5	2.2	8.2	-1.6	2.9	1.9	0.6	0.2	0.3	1.0
Blood Red Count	1.5	14.0	29.7	1.4	-2.6	-0.8	-4.4	-4.2	-4.8	-5.5
Hand grip strength (left)	1.5	4.0	8.1	1.9	-0.6	0.5	-2.8	-1.9	-2.0	-2.8
Mouth/teeth dental problems: Loose teeth	1.5	1.8	4.1	-0.7	1.3	-1.1	1.8	1.0	1.0	2.0
Medication: Omeprazole (e.g. Zanprol)	1.5	1.8	9.0	-3.0	0.8	1.6	0.2	0.0	-0.4	0.6
Fasting Glucose	1.4	1.6	4.2	0.9	0.0	-2.1	-1.3	-1.5	-1.2	-1.0
Worrier / anxious feelings	1.4	2.7	5.5	0.2	2.3	-0.9	2.0	1.8	1.5	1.8
Illnesses of father: Heart disease	1.4	2.0	4.0	-0.3	-0.2	2.0	-2.0	-1.7	-1.3	-1.1
Ever smoked	1.4	2.5	6.3	1.7	-0.8	-0.9	-1.6	-0.8	-1.8	-2.5
Risk taking	1.4	2.1	4.2	0.6	0.8	-0.5	1.3	2.1	2.0	1.9
Pack years adult smoking proportion	1.3	1.9	7.3	1.0	2.7	1.1	0.9	1.2	1.3	0.2
Financial difficulties in last 2 years	1.3	1.8	4.5	-0.1	0.9	-0.3	1.9	1.2	1.5	2.1
Pain all over the body in last month	1.3	1.4	4.6	1.0	2.2	0.5	1.1	0.9	1.1	0.4
Number of children fathered	1.3	1.4	3.0	-1.7	1.2	-0.4	0.9	1.7	0.3	1.3
Osteoarthritis (self-reported)	1.3	1.7	3.3	0.9	1.1	-1.1	1.8	0.4	1.7	1.5
Medication: Blood pressure	1.3	2.4	4.0	0.3	2.0	1.6	1.7	0.9	1.6	2.0
Intelligence (Savage-Jansen 2018)	1.2	3.6	6.7	-0.4	1.8	-1.5	2.4	1.9	1.7	2.6
Medication: Amlodipine	1.2	1.6	2.6	-1.0	1.6	1.5	1.1	0.6	1.5	1.4
Worry too long after embarrassment	1.2	2.0	4.6	-0.1	1.0	-0.5	2.1	1.3	1.4	2.0
Alcohol drinker status: Never	1.2	1.5	3.5	1.0	1.9	1.6	0.7	0.5	1.0	1.2
Alzheimer’s Disease (in father)	1.1	1.2	2.4	-1.5	1.5	1.0	-1.0	-1.3	-0.5	-0.1
Townsend deprivation index at recruitment	1.1	1.6	3.6	-1.9	0.8	-0.7	1.3	0.8	0.8	1.8
Average weekly fortified wine intake	1.1	1.2	3.7	-1.9	0.3	0.4	1.0	0.7	0.5	1.7
Medication for cholesterol, blood pressure or diabetes	1.1	1.7	3.4	0.7	-0.0	-1.8	1.3	1.2	1.7	1.5
Emphysema/chronic bronchitis	1.1	1.2	1.7	1.3	1.1	0.8	1.3	0.8	1.2	1.0
Diabetes diagnosed by doctor	1.1	1.9	3.6	-0.7	-1.0	-0.3	-1.8	-1.4	-1.9	-1.6
Osteoporosis (self-reported)	1.1	1.4	3.4	1.9	-1.8	-0.6	-1.1	-0.4	-0.4	-1.2
Neuroticism score	1.0	2.0	7.0	1.0	2.6	0.2	1.1	1.8	1.0	0.6
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	3.0	-0.7	1.3	1.7	-0.3	-1.3	0.6	0.9
Impedance of arm (left)	1.0	4.7	23.0	-4.8	-0.3	0.8	1.6	0.7	0.8	2.4
Length of working week for main job	1.0	1.1	4.9	-0.4	1.3	-2.2	0.6	-0.2	0.4	0.6
Breastfed as a baby	1.0	1.3	2.9	1.6	0.0	1.7	-1.0	-1.0	-0.2	-1.2
Tense / ‘highly strung’	1.0	1.7	4.0	1.3	2.0	-1.5	1.3	0.8	1.0	0.9
Heart disease (mother)	1.0	1.2	6.0	-2.5	0.7	0.9	0.5	0.5	0.5	0.4
Supplements: Vitamin C	1.0	1.1	2.1	-1.4	-0.0	0.7	0.9	0.8	1.4	1.3
Commuting to job workplace: Cycle	1.0	1.2	2.6	-1.4	-0.4	1.6	1.1	0.5	0.5	1.4
Blood Platelet Count	0.9	10.1	31.8	5.6	-1.7	-1.8	3.0	1.9	4.4	1.1
Waist Hip Ratio (WHR)	0.9	3.9	9.8	-3.1	-3.0	0.8	-1.1	-1.5	-1.9	-1.0
Type 2 Diabetes (T2D) (2018)	0.9	1.7	3.9	-0.4	-0.7	-0.8	-1.5	-1.1	-2.0	-1.7
Lung FVC	0.9	4.6	10.3	0.5	-2.2	0.0	-2.7	-3.2	-2.1	-2.4
Medication: Co-codamol	0.9	1.0	3.1	0.3	0.4	0.5	1.8	1.0	0.9	1.4
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	2.4	-1.0	-0.0	0.6	1.4	1.6	1.4	0.9
Alcohol intake versus 10 years previously	0.9	1.3	4.5	2.1	-1.0	0.7	0.1	1.4	0.4	-0.8
Illnesses of mother	0.9	1.2	3.6	1.9	-0.3	-1.5	-1.0	-0.6	0.3	-0.9
Wheeze or whistling in the chest in last year	0.9	1.7	3.7	-1.9	1.2	-0.7	1.6	1.4	-0.1	1.4
Medication: Allopurinol	0.9	1.2	4.1	-0.6	-0.4	-1.1	-1.3	-2.0	-0.7	-0.3
Illnesses of father: None of the above (group 1)	0.9	1.1	1.8	-1.3	-0.8	-0.8	1.0	1.3	0.7	1.2
Medication: Lisinopril	0.9	1.2	3.8	1.2	0.9	0.0	1.2	1.9	0.6	0.8
Illnesses of father: High blood pressure	0.9	1.1	5.3	0.9	1.0	2.3	-0.3	0.2	0.3	-0.6
Pain experienced in last month	0.9	1.5	2.8	0.6	-1.7	-1.3	-1.5	-0.7	-1.0	-1.2
Supplements: Calcium	0.9	1.0	2.9	0.1	0.3	-1.4	0.8	0.8	1.7	0.9
Neuroticism	0.8	1.9	5.8	1.0	2.4	-0.7	1.0	1.9	1.0	0.3
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	5.2	-2.3	-0.6	-0.2	0.2	0.0	0.4	0.1
Hand grip strength (right)	0.8	2.2	4.5	1.8	0.4	1.0	-2.1	-1.3	-1.2	-1.8
Maternal smoking around birth	0.8	1.1	2.8	1.4	1.3	-0.6	0.7	0.7	1.7	0.2
Alcohol usually taken with meals	0.8	1.4	8.3	0.7	0.4	2.9	-0.3	-0.0	0.6	-0.4
Nervous feelings	0.8	1.4	3.7	0.5	1.9	0.8	1.3	0.7	1.2	1.3
Qualifications: None of the above	0.8	1.8	3.8	1.5	1.9	0.7	1.2	0.7	1.9	0.6
Impedance of arm (right)	0.8	3.5	18.2	-4.3	-0.6	0.4	1.1	0.6	0.6	2.0
Falls in the last year	0.8	1.0	2.9	0.4	1.0	0.0	1.7	0.5	1.3	1.1
Qualifications: A levels/AS levels or equivalent	0.8	1.7	5.4	-1.8	-2.3	0.4	-0.5	-1.7	-0.5	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.3	3.3	-0.8	1.8	-1.7	0.4	-0.2	0.8	1.2
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	4.1	-1.6	-1.0	-2.0	0.3	-0.0	0.4	0.8
Mean time to correctly identify matches	0.8	1.6	5.9	-0.7	2.4	0.2	0.8	0.8	1.4	1.1
Pulse rate, automated reading	0.8	2.5	5.6	1.4	0.4	0.0	-1.6	-2.4	-1.6	-2.2
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.9	1.7	-0.1	-1.2	-0.7	-0.6	-0.5	-1.0
Eye problems/disorders: Cataract	0.8	0.9	2.5	-1.6	-0.3	1.4	-0.6	-0.9	-0.7	-0.2
Mineral and other dietary supplements	0.8	1.1	2.5	-1.1	-0.7	-1.5	-0.5	0.3	-1.6	-0.9
Medication: Aspirin	0.8	1.0	2.2	1.3	-0.6	0.1	-1.0	-1.5	-0.7	-1.1
Commuting to job workplace: Public transport	0.8	1.0	3.8	-1.9	-0.1	-0.5	0.9	0.3	0.4	1.3
Basal cell carcinoma (self-reported)	0.8	1.0	2.6	-1.0	0.2	-1.6	-0.5	-1.2	-1.2	0.1
Depressed Affect (Nagel 2018)	0.7	1.4	4.6	0.3	2.1	1.3	1.0	1.2	0.8	0.8
Schizophrenia vs Biploar Disorder	0.7	0.9	3.4	0.3	-1.9	1.1	0.7	0.3	0.6	0.7
Worry (Nagel 2018)	0.7	1.5	4.7	0.8	2.2	0.3	1.2	1.1	1.4	0.9
Prostate Cancer	0.7	1.0	2.5	-1.1	0.1	1.3	1.0	0.7	0.6	1.6
Allergy or Eczema	0.7	1.9	5.1	0.2	-1.2	-0.5	1.6	2.3	1.7	1.1
Average weekly spirits intake	0.7	0.8	2.2	-1.0	-1.5	0.2	-0.8	-1.1	-0.7	-0.6
Sensitivity / hurt feelings	0.7	1.3	3.7	0.9	0.5	-1.7	1.0	1.9	0.5	0.5
Medication for hormone replacement therapy	0.7	0.8	2.1	-0.3	-0.9	1.0	-0.7	-0.7	-1.5	-0.7
Stomach or abdominal pain in last month	0.7	0.9	2.3	0.2	0.1	-1.2	-1.2	-0.7	-0.9	-1.5
Supplements: Glucosamine	0.7	0.9	2.9	1.7	-0.2	-0.7	-0.8	-1.4	0.6	-0.2
Chronic bronchitis/emphysema (father)	0.7	0.8	2.0	1.4	0.2	0.1	1.4	0.3	1.1	0.6
Past tobacco smoking	0.7	1.3	3.7	-1.2	0.5	0.5	1.2	0.3	1.4	1.9
Mouth/teeth dental problems: Dentures	0.7	1.1	3.6	0.1	1.9	1.9	-0.6	-0.5	-0.1	-0.5
Depression (self-reported)	0.7	0.9	2.0	-1.2	0.9	-1.4	-0.0	0.2	-1.4	-0.2
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	5.6	-2.4	-0.5	0.2	0.3	0.2	0.0	0.4
Glaucoma (self-reported)	0.7	0.8	5.3	2.3	-0.0	0.5	-0.2	0.4	0.2	-0.2
Number of full sisters	0.7	0.9	2.5	1.2	0.2	-0.1	-1.1	-0.8	-0.3	-1.6
Suffer from ‘nerves’	0.7	1.0	3.4	1.1	1.8	-1.2	0.3	-0.2	0.8	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.0	0.1	0.2	-0.9	-1.1	-0.4	-1.2	-1.4
Illnesses of siblings: Diabetes	0.7	0.9	3.0	-0.9	-0.5	-1.7	-0.2	-1.0	-1.0	0.0
Average weekly red wine intake	0.7	1.0	2.2	1.5	-0.9	0.3	-1.1	-1.1	-0.2	-1.1
Friendships satisfaction	0.7	0.8	1.9	-0.9	-0.9	-1.4	-0.8	0.0	-1.2	-0.4
Back pain experienced in last month	0.7	1.0	2.4	0.9	0.7	0.4	1.3	0.1	1.5	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	6.8	-0.3	1.0	2.6	-1.1	-1.0	-0.4	-0.3
Average weekly champagne plus white wine intake	0.7	1.0	4.1	-1.2	-1.0	2.0	-0.4	-0.5	-0.4	-0.2
Miserableness	0.7	1.2	4.7	-0.5	2.2	0.7	0.8	1.2	0.6	0.8
Hearing aid user	0.7	0.8	2.7	-1.7	0.8	-0.1	0.4	-0.9	0.6	0.9
Cholesterol lowering medication	0.7	1.1	4.2	1.3	-0.6	-2.0	-0.3	-1.1	-0.3	0.2
Heart disease (siblings)	0.7	0.9	3.6	-0.9	0.5	1.9	0.6	0.5	0.8	0.5
Body Mass Index (BMI) (2010)	0.6	0.9	4.1	2.0	0.8	-1.1	0.3	0.1	0.1	0.3
Number of treatments/medications taken	0.6	1.0	4.3	-0.4	0.4	2.1	0.9	-0.8	0.5	0.7
Taking other prescription medications	0.6	0.9	2.1	-1.2	-0.9	1.2	-0.4	-1.5	-0.6	-0.2
Number of incorrect matches in round	0.6	1.0	3.0	0.1	-1.7	-0.9	-0.9	-1.0	-0.5	-0.9
Mouth/teeth dental problems	0.6	0.9	3.9	2.0	-1.2	-0.9	0.2	-0.2	0.4	-0.2
Medication: Simvastatin	0.6	0.9	3.3	0.6	0.5	-1.8	-0.6	-1.4	-0.6	0.1
Time employed in main current job	0.6	0.7	1.8	-0.9	0.2	-0.8	1.2	0.1	-0.0	1.3
Number of live births	0.6	0.9	2.2	0.7	-0.9	-0.4	-1.0	-1.5	-0.2	-1.1
Happiness	0.6	0.7	1.5	0.7	-1.2	-0.0	-1.1	0.0	-0.9	-0.9
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.3	-0.5	1.3	0.8	0.3	1.5	-0.2	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.5	-0.2	-1.1	0.0	0.8	0.3	1.2	1.2
Shortness of breath walking on level ground	0.6	0.7	1.9	-0.4	1.1	1.4	0.4	-0.0	0.7	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	1.9	1.1	0.0	1.1	0.9	1.4	0.4	-0.0
Medication: Aspirin	0.6	0.8	2.0	1.4	-0.6	0.2	-0.8	-1.4	-0.4	-0.9
Ever had bowel cancer screening	0.6	0.7	2.0	1.4	-0.7	-0.4	-0.6	-0.4	0.1	-1.4
Asthma (self-reported)	0.6	1.3	3.2	-1.3	1.8	0.1	1.2	1.5	0.3	0.7
Wears glasses or contact lenses	0.6	0.7	3.5	-0.4	0.7	1.9	0.1	0.1	0.8	0.4
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.7	-0.4	0.5	1.2	1.1	-0.6	0.7	1.3
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.7	0.3	0.7	1.3	1.0	0.4	1.1	1.1
Medication: Bendroflumethiazide	0.6	0.9	1.6	-0.5	0.7	1.0	1.0	-1.1	0.8	1.3
Average weekly beer plus cider intake	0.6	0.8	2.0	0.1	0.6	0.4	1.0	0.7	1.4	1.3
Fractured/broken bones in last 5 years	0.6	0.8	1.5	-0.1	-0.9	-1.1	-0.7	-0.7	-1.2	-1.1
Bipolar Disorder (2018)	0.5	0.8	3.3	0.7	1.8	-0.1	-0.2	0.8	-0.2	-0.9
Neuroticism (Nagel 2018)	0.5	1.1	2.8	0.3	1.7	0.6	1.2	1.2	1.0	0.9
Ulcerative Colitis (UC)	0.5	0.9	2.4	0.4	-0.4	-0.6	1.4	0.7	0.8	1.5
Coronary Artery Disease (CAD)	0.5	0.6	2.1	-1.4	-0.6	-1.2	0.3	0.1	-0.5	0.3
Cardiovascular Disease	0.5	1.6	5.2	-2.3	0.3	1.7	0.2	-1.3	-0.2	1.2
Hypothyroidism (self reported)	0.5	1.2	5.3	-0.5	-0.6	2.3	0.8	-0.1	0.5	1.2
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.5	-0.9	0.5	1.2	0.9	-0.3	0.3	0.9
Angina	0.5	0.6	2.9	-1.7	-0.4	0.8	0.5	0.1	-0.0	0.6
Severe depression (siblings)	0.5	0.5	1.3	-0.3	-0.1	-1.0	-1.1	-0.3	-0.4	-1.1
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.7	-0.5	0.1	-1.3	0.6	1.2	-0.5	0.1
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.6	0.4	-1.2	-0.1	1.0	1.6	1.4	0.4
Medication: Atenolol	0.5	0.7	2.2	0.9	-0.0	-0.3	-0.7	-1.5	-0.5	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	2.9	-0.3	1.7	0.5	0.6	1.1	0.0	0.5
Illnesses of siblings	0.5	0.7	2.2	1.5	-0.8	-0.4	-0.8	0.5	-0.2	-0.9
Trunk fat-free mass	0.5	2.7	10.4	3.2	-0.5	0.7	-1.6	-1.6	-0.7	-1.5
Asthma	0.5	0.9	2.6	-1.1	1.6	-0.0	0.8	1.3	0.1	0.5
Pulse wave Arterial Stiffness index	0.5	0.6	2.0	1.4	-1.2	-0.3	0.2	0.4	0.5	-0.7
Trunk predicted mass	0.5	2.8	10.4	3.2	-0.6	0.7	-1.6	-1.6	-0.7	-1.5
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	5.1	0.1	-0.9	2.3	0.2	-0.3	0.0	0.3
Arm fat-free mass (right)	0.5	2.4	13.0	3.6	-0.2	0.5	-1.1	-1.1	-0.3	-0.9
Age at first live birth	0.5	0.9	1.9	1.4	-0.9	1.1	-0.8	-0.7	-0.3	-1.1
Angina (self-reported)	0.5	0.7	2.6	-1.6	-0.1	0.9	0.7	0.2	0.2	0.8
Migraine (self-reported)	0.5	0.6	2.2	-0.3	-0.6	1.5	0.8	-0.8	0.4	0.6
Medication: Ibuprofen	0.5	0.6	1.3	0.4	-0.5	0.6	-1.1	-0.4	-1.0	-1.2
Arm predicted mass (right)	0.5	2.5	13.5	3.7	-0.1	0.4	-1.1	-1.2	-0.3	-1.0
Alcohol intake frequency.	0.5	1.1	3.4	0.2	0.7	0.4	1.1	1.8	1.3	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	3.2	-1.8	0.3	-0.2	0.3	-0.0	-0.0	0.8
Loneliness, isolation	0.5	0.7	1.6	-1.2	0.2	1.0	-0.5	-1.2	-1.0	-0.2
Mother’s age at death	0.5	0.6	2.4	0.6	-0.4	1.6	-0.8	-0.2	-0.7	-0.5
Irritability	0.5	0.9	2.0	0.6	1.2	-1.2	1.0	1.4	0.2	0.0
Ever had prostate specific antigen (PSA) test	0.5	0.6	2.9	-0.5	0.7	1.7	0.2	0.2	0.6	0.4
Crohns Disease (2017)	0.4	0.8	2.6	-1.6	-0.1	1.4	-0.3	-0.6	-0.7	0.2
Ovarian Cancer	0.4	0.6	1.3	0.7	-1.1	0.2	-0.6	0.8	-0.7	-0.8
Crohns Disease (2012)	0.4	0.7	2.6	-1.5	0.0	1.6	0.0	-0.4	0.0	0.0
HDL Cholesterol	0.4	0.6	1.5	0.2	-0.8	1.2	-0.6	-0.7	-1.0	-0.5
LDL Cholesterol	0.4	0.7	1.4	-1.2	-0.6	-0.9	-0.9	-1.2	-0.1	-0.4
Neuroticism (2016)	0.4	0.6	1.6	0.6	0.7	-1.3	0.7	0.4	0.9	0.7
Primary Biliary Cirrhosis	0.4	0.6	1.3	1.2	0.5	0.0	1.1	-0.1	0.9	0.7
Smoking Status	0.4	1.0	4.0	1.2	-0.4	-2.0	-0.3	-0.4	-0.5	-0.7
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.7	-1.0	1.3	-0.4	0.2	0.5	0.4	0.6
Diabetes (father)	0.4	0.4	1.0	0.7	0.2	0.2	1.0	0.9	0.6	0.5
Diabetes (mother)	0.4	0.6	1.3	-0.6	-0.1	-0.1	-0.7	-1.1	-1.1	-0.8
Fed-up feelings	0.4	0.7	3.9	-0.1	2.0	0.3	-0.3	0.1	-0.8	-0.4
Age when periods started (menarche)	0.4	0.9	2.3	1.0	1.4	1.5	0.5	0.0	0.9	-0.1
Serious illness, injury or assault to yourself	0.4	0.5	2.2	-1.5	-0.3	-0.9	0.7	-0.2	-0.1	0.4
High blood pressure	0.4	1.2	4.8	-0.9	1.1	2.2	0.8	-0.1	0.7	0.9
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.3	0.5	0.7	-1.0	0.2	0.6	-1.1	0.0
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.4	-0.2	-0.5	0.4	-0.8	0.1	-1.2	-1.0
Prospective memory result	0.4	0.5	1.6	1.3	0.5	-0.7	-0.6	-0.2	-0.4	-0.8
Hair/balding pattern: Pattern 4	0.4	0.9	1.6	0.7	1.1	-1.2	1.0	1.0	1.0	0.0
Blood clot in the leg (DVT)	0.4	0.5	1.7	-0.2	1.3	-0.1	0.6	-0.3	0.7	0.8
Exposure to tobacco smoke outside home	0.4	0.6	3.3	1.8	0.4	-0.4	0.1	-0.3	0.6	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.9	-0.1	0.8	-1.4	0.2	-0.1	-0.7	-0.4
Pulse wave peak to peak time	0.4	0.5	1.7	-1.3	0.8	0.4	-0.3	-0.4	-0.6	0.5
Eye problems/disorders: None of the above	0.4	0.5	1.0	-0.0	-0.1	-0.7	-0.8	-1.0	-0.9	-0.8
Hypertension (Self-reported)	0.4	1.1	3.9	-1.2	0.8	2.0	0.8	-0.3	0.5	1.0
Mood swings	0.4	0.7	1.9	0.3	1.4	0.0	-0.9	0.1	-1.0	-1.2
Long-standing illness, disability or infirmity	0.4	0.7	3.6	-0.5	-0.2	1.9	0.5	-0.6	0.2	0.2
Medication for cholesterol	0.4	0.6	1.9	0.0	-1.4	-0.5	-0.4	0.2	0.0	-1.2
Number of self-reported non-cancer illnesses	0.4	0.7	1.6	-1.3	0.8	0.5	1.3	-0.4	0.1	0.8
Eye problems/disorders: Glaucoma	0.4	0.5	2.3	1.5	0.3	0.0	0.4	0.1	0.7	0.6
Arm fat-free mass (left)	0.4	2.1	10.9	3.3	-0.0	0.4	-1.1	-1.3	-0.2	-0.9
Number of operations (self-reported)	0.4	0.6	1.0	-0.4	-0.1	1.0	1.0	0.9	1.0	0.1
Diastolic blood pressure, automated reading	0.4	1.3	6.7	-0.2	-1.2	2.6	0.3	-0.7	-0.6	-0.1
Vascular/heart problems diagnosed by doctor	0.4	1.2	4.0	1.6	-0.6	-2.0	-0.2	1.0	-0.1	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	2.0	-0.0	1.4	0.1	0.8	-0.1	0.7	0.9
Impedance of whole body	0.4	1.8	10.3	-3.2	-0.7	0.2	0.7	-0.1	0.2	1.2
Arm predicted mass (left)	0.4	2.3	12.9	3.6	0.1	-0.0	-1.0	-1.1	-0.2	-0.8
Depression (Nagel 2018)	0.3	0.5	1.2	-0.2	-0.0	0.4	-1.1	-0.9	-0.5	-1.1
Mean Putamen Volume	0.3	0.4	1.0	0.5	1.0	-0.5	-0.1	-0.3	0.9	-0.2
HbA1C	0.3	0.3	0.6	-0.2	-0.1	-0.7	-0.5	-0.6	-0.8	-0.5
Blood Eosinophil Count	0.3	2.0	7.5	-0.2	2.7	-0.7	1.5	0.8	1.4	1.1
BMI	0.3	1.6	6.2	1.7	2.5	0.6	0.6	0.5	0.6	0.9
Respiratory disease	0.3	0.7	1.6	-0.8	0.7	0.3	1.1	1.3	0.6	0.9
Lung FEV1/FVC ratio	0.3	1.5	8.1	0.3	2.9	-0.1	0.4	1.4	0.3	0.6
Tanning	0.3	3.7	6.6	-0.3	-1.6	-1.6	-2.6	-2.4	-2.1	-2.0
Relative age of first facial hair	0.3	0.7	1.5	-1.2	0.2	0.5	0.9	1.2	-0.4	0.7
Trunk fat percentage	0.3	1.1	2.5	-0.9	1.2	0.8	1.1	0.5	0.6	1.6
Relative age voice broke	0.3	0.5	1.8	-0.6	0.5	0.9	-0.2	-0.0	-1.4	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.9	-0.8	1.1	1.4	0.1	0.6	-0.8	-0.4
Qualifications: CSEs or equivalent	0.3	0.3	1.3	-0.5	0.2	0.7	-0.2	-0.3	-1.1	-0.3
Medication: Levothyroxine sodium	0.3	0.5	2.7	-0.1	0.3	1.6	0.4	0.1	0.5	0.4
Sitting height	0.3	1.9	5.8	0.2	-1.1	1.0	-1.9	-2.4	-1.0	-0.8
Forced vital capacity (FVC)	0.3	1.1	3.7	0.5	-1.0	1.0	-1.1	-1.9	-0.7	-0.6
Allergy	0.3	0.7	2.8	-0.5	0.2	0.4	-1.0	-1.7	-0.9	-0.1
Father’s age at death	0.3	0.4	1.5	-0.1	-0.2	1.2	-0.5	-1.0	-0.0	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.8	-0.1	1.2	1.4	0.0	0.2	-0.1	-0.3
Medication: Lansoprazole	0.3	0.4	1.8	0.1	-1.4	-0.4	-0.1	0.3	-0.7	-0.3
Peak expiratory flow (PEF)	0.3	0.7	2.0	1.0	1.0	1.4	0.4	0.3	0.8	0.5
Headache pain in last month	0.3	0.5	1.0	-0.5	1.0	0.7	0.9	0.8	-0.4	0.7
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.3	-1.1	-0.8	0.6	0.4	-0.4	0.0	0.3
Forced vital capacity (FVC), Best measure	0.3	1.1	2.7	0.4	-0.8	1.6	-1.2	-1.4	-0.5	-0.5
Health satisfaction	0.3	0.4	2.2	-0.4	0.2	1.5	0.1	-0.1	-0.6	0.3
Qualifications: College or University degree	0.3	1.1	3.2	-1.4	-1.8	0.8	0.1	-0.6	-1.1	0.4
Neck or shoulder pain in last month	0.3	0.4	1.4	1.2	0.4	0.8	0.5	0.4	0.5	0.2
Medication: Blood pressure	0.3	0.5	2.4	-0.2	0.3	1.5	-0.4	-0.4	-0.5	-0.8
Chest pain or discomfort	0.3	0.4	1.1	-0.0	-0.3	1.0	0.2	-0.7	0.5	0.8
Had major operations	0.3	0.3	1.2	0.1	-1.1	-0.3	-0.7	-0.4	-0.0	-0.5
Leg pain on walking	0.3	0.3	1.6	1.3	-0.2	-0.4	-0.4	-0.4	0.4	-0.3
Whole body fat-free mass	0.3	1.5	7.8	2.8	-0.1	0.7	-1.0	-1.0	-0.2	-0.7
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.2	-0.2	-0.7	-0.4	0.2	1.1	-0.1	-0.5
Commuting to job workplace: Walk	0.3	0.3	1.1	-0.1	-0.5	1.0	-0.6	-0.5	0.2	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.1	-0.5	-0.9	-0.7	-0.6	0.3	-1.0	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	2.1	1.4	0.4	0.4	-0.1	-0.2	0.0	-0.2
Smoking status: Current	0.3	0.4	1.1	0.8	-1.0	-0.5	-0.3	-0.5	-0.2	-0.9
Whole body water mass	0.3	1.5	8.1	2.8	0.0	0.7	-0.9	-0.9	-0.1	-0.5
Financial situation satisfaction	0.3	0.3	1.0	-0.1	-0.7	0.2	-1.0	0.2	-0.7	-0.4
Alcohol drinker status: Previous	0.3	0.3	1.4	-0.4	-0.7	0.1	0.2	1.2	-0.2	-0.5
Bipolar Disorder or Schizophrenia	0.2	0.6	1.4	1.1	0.6	0.4	0.3	1.2	0.1	-0.7
Schizophrenia (2018)	0.2	0.5	1.0	0.8	-0.4	1.0	0.8	0.9	0.3	-0.2
Irritable Bowel Disease (IBD)	0.2	0.5	1.4	-0.8	-0.2	0.8	0.8	0.3	0.2	1.2
Breast Cancer	0.2	0.6	2.6	-1.6	-0.4	0.4	-0.2	-0.6	-0.7	0.4
Age at First Birth	0.2	0.2	0.7	0.6	-0.8	0.3	-0.5	-0.4	0.1	-0.4
Lupus	0.2	0.3	1.2	0.0	0.0	1.1	-0.2	-0.4	0.7	0.4
Schizophrenia (2014)	0.2	0.4	1.1	1.0	-1.0	0.4	-0.1	0.7	-0.0	-0.6
Ulcerative Colitis	0.2	0.4	0.9	0.9	-0.4	1.0	0.6	-0.3	0.2	0.4
Heel T-Score	0.2	1.9	5.2	0.9	2.3	2.1	0.9	1.4	-0.3	-0.1
Ever used hormone-replacement therapy (HRT)	0.2	0.3	1.1	-0.3	-0.0	1.1	0.3	-0.4	-0.5	-0.2
Ever had hysterectomy (womb removed)	0.2	0.2	1.0	-1.0	0.2	-0.1	-0.3	-0.2	-0.4	0.2
Systolic blood pressure, automated reading	0.2	0.7	1.4	0.5	-1.1	-0.0	-0.5	-0.8	-1.2	-1.2
Impedance of leg (right)	0.2	1.0	1.7	-1.1	-1.0	-0.5	-0.9	-1.2	-1.3	-0.8
Current tobacco smoking	0.2	0.3	0.9	0.9	-0.8	-0.5	-0.0	-0.1	0.2	-0.6
High blood pressure (mother)	0.2	0.3	1.7	0.2	0.3	1.3	-0.1	-0.0	-0.4	-0.3
Had other major operations	0.2	0.2	1.2	-0.0	-0.3	0.1	-0.1	0.0	-1.1	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.6	-0.3	1.3	0.8	0.3	0.2	-0.5	-0.2
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	1.0	0.1	-0.5	0.4	-0.4	0.1	-1.0	-0.6
Heart attack	0.2	0.2	1.2	-0.4	0.1	0.2	0.1	-1.1	0.1	0.4
Arm fat percentage (right)	0.2	0.6	1.1	-0.8	1.1	0.8	0.7	0.5	0.3	1.0
Hip circumference	0.2	0.8	2.1	1.3	1.5	0.5	0.6	0.3	0.6	1.0
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	2.0	0.2	-0.0	1.2	-0.9	-1.4	-0.5	-0.1
Pulse rate	0.2	0.3	0.8	0.7	0.3	0.6	-0.3	-0.9	-0.3	-0.8
Lung cancer (father)	0.2	0.2	1.1	0.1	-1.1	0.5	0.3	0.2	0.3	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	2.3	0.5	0.5	1.5	-1.0	-1.1	-0.3	-0.1
Loud music exposure frequency	0.2	0.3	0.7	0.0	0.3	0.1	0.6	0.8	0.3	0.7
High blood pressure (siblings)	0.2	0.3	0.7	0.4	0.9	0.4	0.8	0.2	-0.1	0.6
Leg fat mass (right)	0.2	0.6	1.7	1.3	0.9	0.5	-0.6	-0.7	-0.5	-0.4
Overall health rating	0.2	0.3	1.2	0.2	1.1	0.9	-0.1	-0.3	0.2	-0.3
Age at last live birth	0.2	0.3	1.1	0.6	-1.0	-0.6	-0.2	-0.4	0.2	-0.3
Arm fat percentage (left)	0.2	0.7	1.3	-1.0	1.0	1.1	0.8	0.4	0.2	1.0
Guilty feelings	0.2	0.3	0.8	0.4	0.9	0.4	0.2	0.6	0.5	0.1
Ever taken oral contraceptive pill	0.2	0.2	0.7	-0.5	0.1	-0.7	-0.4	0.2	-0.8	-0.2
Basal metabolic rate	0.2	1.1	6.2	2.5	0.3	0.7	-0.6	-0.8	0.1	-0.2
Age started oral contraceptive pill	0.2	0.2	0.6	-0.7	0.3	0.7	-0.3	-0.4	-0.0	0.4
Ever depressed for a whole week	0.2	0.2	0.5	0.7	-0.6	0.5	0.0	0.3	0.4	0.0
Heart attack/myocardial infarction (self-reported)	0.2	0.3	1.8	-0.2	0.0	0.1	0.1	-1.3	-0.1	0.3
Leg fat mass (left)	0.2	0.6	2.6	1.6	1.0	0.3	-0.5	-0.6	-0.3	-0.3
Triglycerides	0.1	0.2	0.6	-0.1	0.4	-0.8	0.1	0.4	0.1	-0.4
Height	0.1	1.7	3.6	1.4	-1.9	1.8	-0.2	-1.6	0.4	0.3
Systolic Blood Pressure	0.1	0.3	0.7	0.8	-0.4	-0.7	0.0	0.5	-0.2	-0.8
Chronotype (morning person)	0.1	0.2	0.5	0.4	0.3	0.2	0.5	0.7	0.3	0.1
Leg fat-free mass (left)	0.1	0.5	1.9	1.4	0.5	1.0	0.0	-0.1	0.5	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	-0.1	0.3	-0.2	-0.4	0.0	-0.4	-0.4
Body mass index (BMI)	0.1	0.6	2.4	1.1	1.5	0.1	0.5	0.4	0.2	0.4
Impedance of leg (left)	0.1	0.6	1.4	-0.4	-0.8	-1.2	-0.7	-0.7	-0.9	-0.7
Leg predicted mass (left)	0.1	0.5	2.1	1.4	0.5	1.0	-0.0	-0.2	0.5	0.5
Trunk fat mass	0.1	0.4	0.9	-0.1	0.9	0.9	0.5	-0.1	0.2	0.9
Had menopause	0.1	0.1	0.3	0.5	0.2	0.4	-0.2	-0.4	-0.1	-0.0
Weight	0.1	0.4	1.2	1.1	1.0	0.6	0.3	-0.2	0.2	0.7
Noisy workplace	0.1	0.1	0.4	-0.7	-0.0	-0.2	0.3	0.3	-0.2	0.3
Arm fat mass (right)	0.1	0.3	1.0	0.4	1.0	0.6	0.3	0.0	0.3	0.7
Standing height	0.1	0.6	1.3	0.6	-1.1	1.1	-0.4	-1.1	0.2	0.4
Pulse wave reflection index	0.1	0.1	0.4	0.5	-0.7	-0.0	-0.3	0.2	0.3	-0.4
Body fat percentage	0.1	0.4	1.2	-0.4	1.1	0.6	0.5	0.2	0.2	0.9
Leg fat percentage (right)	0.1	0.5	0.8	0.6	0.9	0.6	-0.5	-0.9	-0.9	-0.5
Medication for pain relief, constipation, heartburn	0.1	0.2	0.9	-0.4	-0.4	-0.1	-1.0	-0.5	-0.3	-0.4
Whole body fat mass	0.1	0.3	0.8	0.6	0.9	0.4	0.3	-0.1	0.2	0.6
Comparative height size at age 10	0.1	0.6	1.3	1.1	-0.9	0.6	-0.6	-1.2	-0.0	-0.1
Smoking status: Previous	0.1	0.2	0.5	0.7	0.3	-0.1	-0.3	0.5	-0.2	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.1	0.9	-0.9	-0.1	-0.0	-0.1	-0.2	0.2	0.2
Leg fat-free mass (right)	0.1	0.7	2.9	1.7	0.5	0.8	0.1	0.2	0.6	0.6
Breast cancer (self-reported)	0.1	0.2	0.7	-0.8	0.4	-0.4	-0.0	-0.2	0.2	0.1
Leg predicted mass (right)	0.1	0.6	2.7	1.6	0.5	0.9	0.0	0.1	0.6	0.5
Arm fat mass (left)	0.1	0.5	1.4	0.4	1.2	0.6	0.6	0.3	0.4	0.9
Leg fat percentage (left)	0.1	0.4	1.1	1.1	0.9	0.2	-0.3	-0.6	-0.5	-0.3
Unable to work because of sickness or disability	0.1	0.2	0.8	-0.7	-0.0	0.1	-0.1	0.2	-0.9	-0.3
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.6	3.4	0.7	-0.2	1.8	-0.1	0.3	-0.1	0.2
Waist circumference	0.0	0.1	0.5	0.1	0.1	0.2	-0.0	-0.4	-0.7	-0.1

Hub : Genes

ADPRHL1

Models

Trait associations