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chr14:77,043,210-78,634,174

Best TWAS P=2.86e-19 · Best GWAS P=4.36e-17 conditioned to 0.373

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
29	GTEx	Spleen	TMED8	0.30	0.07	lasso	6	0.15	1.1e-04	-7.6	9.0	2.9e-19	0.89	0.07	0.74	TRUE
17	GTEx	Esophagus Mucosa	NOXRED1	0.12	0.05	lasso	3	0.04	7.3e-04	-7.8	-8.6	8.7e-18	-0.95	0.03	0.96	FALSE
45	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C14orf148	0.02	0.02	enet	5	0.01	1.1e-02	8.4	-8.5	2.8e-17	-0.99	0.01	0.89	FALSE
50	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C14orf148	0.11	0.02	blup	53	0.04	6.7e-03	8.3	-8.4	6.6e-17	-0.91	0.01	0.87	FALSE
38	The Cancer Genome Atlas	Breast Invasive Carcinoma	C14orf174	0.02	0.02	lasso	2	0.02	6.0e-05	8.3	8.3	7.5e-17	1.00	0.01	0.99	FALSE
35	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C14orf148	0.04	0.06	enet	5	0.07	1.9e-06	8.3	-8.3	8.4e-17	-1.00	0.01	0.99	FALSE
52	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C14orf148	0.05	0.01	blup	53	0.02	2.2e-03	-7.7	-8.3	1.0e-16	-0.93	0.02	0.97	FALSE
49	The Cancer Genome Atlas	Brain Lower Grade Glioma	C14orf174	0.03	0.03	blup	43	0.03	2.3e-04	8.4	8.2	2.8e-16	0.95	0.01	0.97	FALSE
22	GTEx	Nerve Tibial	VIPAS39	0.09	0.06	lasso	5	0.04	6.6e-04	8.3	8.1	5.5e-16	1.00	0.01	0.99	FALSE
40	The Cancer Genome Atlas	Colon Adenocarcinoma	C14orf148	0.04	0.02	blup	53	0.03	5.2e-03	8.4	-8.1	5.5e-16	-0.97	0.01	0.85	FALSE
59	The Cancer Genome Atlas	Thyroid Carcinoma	AHSA1	0.03	0.03	enet	7	0.03	9.9e-04	7.7	-8.1	7.0e-16	-0.94	0.02	0.96	FALSE
20	GTEx	Lung	VIPAS39	0.08	0.02	enet	15	0.02	1.6e-02	-7.7	8.0	9.7e-16	0.97	0.02	0.98	FALSE
27	GTEx	Skin Sun Exposed Lower leg	VIPAS39	0.14	0.14	lasso	3	0.13	8.9e-11	-7.8	7.9	2.1e-15	0.97	0.06	0.94	FALSE
61	The Cancer Genome Atlas	Thyroid Carcinoma	C14orf174	0.11	0.14	enet	11	0.14	6.2e-14	-7.7	7.9	2.1e-15	0.98	0.02	0.98	FALSE
41	The Cancer Genome Atlas	Glioblastoma Multiforme	C14orf174	0.11	0.05	blup	43	0.04	1.7e-02	-7.7	7.9	2.6e-15	0.90	0.01	0.53	FALSE
5	GTEx	Adrenal Gland	NOXRED1	0.24	0.15	lasso	5	0.09	3.7e-04	8.4	-7.9	2.9e-15	-0.93	0.01	0.97	FALSE
13	GTEx	Cells EBV-transformed lymphocytes	NOXRED1	0.32	0.20	lasso	7	0.18	1.4e-06	-7.8	-7.9	3.8e-15	-0.97	0.01	0.98	FALSE
32	GTEx	Whole Blood	TMED8	0.14	0.09	enet	17	0.07	8.1e-07	8.4	7.8	5.2e-15	0.97	0.01	0.99	FALSE
23	GTEx	Nerve Tibial	NOXRED1	0.19	0.16	lasso	7	0.16	1.1e-11	-7.7	-7.8	6.1e-15	-0.97	0.02	0.98	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SAMD15	0.11	0.11	lasso	3	0.12	7.6e-14	-7.7	7.8	7.7e-15	0.92	0.11	0.89	FALSE
51	The Cancer Genome Atlas	Lung Adenocarcinoma	C14orf174	0.02	0.03	lasso	1	0.02	6.1e-04	-7.7	7.7	1.0e-14	0.96	0.01	0.96	FALSE
48	The Cancer Genome Atlas	Brain Lower Grade Glioma	C14orf148	0.10	0.08	blup	53	0.10	2.6e-11	-7.7	-7.7	1.1e-14	-0.89	0.06	0.94	FALSE
56	The Cancer Genome Atlas	Prostate Adenocarcinoma	AHSA1	0.02	0.02	enet	5	0.02	4.0e-03	-7.7	-7.7	1.1e-14	-0.98	0.02	0.91	FALSE
57	The Cancer Genome Atlas	Prostate Adenocarcinoma	C14orf148	0.05	0.05	blup	53	0.05	2.5e-06	-7.7	-7.7	1.1e-14	-0.97	0.02	0.98	FALSE
3	GTEx	Adipose Subcutaneous	VIPAS39	0.07	0.06	lasso	4	0.04	3.7e-04	-7.6	7.7	1.3e-14	0.96	0.09	0.90	FALSE
14	GTEx	Cells Transformed fibroblasts	NOXRED1	0.08	0.07	lasso	5	0.06	3.2e-05	-7.7	-7.7	1.3e-14	-0.97	0.03	0.96	FALSE
19	GTEx	Lung	TMED8	0.16	0.16	enet	19	0.17	6.3e-13	-7.7	7.7	1.6e-14	0.94	0.02	0.98	FALSE
54	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C14orf148	0.06	0.09	lasso	7	0.07	4.8e-04	-7.7	-7.7	1.8e-14	-0.97	0.03	0.92	FALSE
30	GTEx	Testis	VIPAS39	0.26	0.18	enet	13	0.15	3.4e-07	-7.8	7.6	2.1e-14	0.97	0.09	0.91	FALSE
55	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C14orf148	0.09	0.07	blup	53	0.07	1.3e-03	7.7	-7.6	2.1e-14	-0.97	0.03	0.88	FALSE
15	GTEx	Colon Transverse	NOXRED1	0.16	0.14	enet	19	0.17	1.2e-08	-7.7	-7.6	3.1e-14	-0.93	0.04	0.96	FALSE
12	GTEx	Breast Mammary Tissue (Male)	TMED8	0.25	0.02	lasso	5	-0.01	6.1e-01	8.4	7.5	7.7e-14	0.91	0.04	0.60	FALSE
11	GTEx	Breast Mammary Tissue	VIPAS39	0.08	0.02	enet	7	0.00	3.1e-01	-7.6	7.5	8.0e-14	0.97	0.06	0.88	FALSE
28	GTEx	Skin Sun Exposed Lower leg	NOXRED1	0.16	0.14	lasso	6	0.14	3.0e-11	-7.6	-7.5	9.2e-14	-0.92	0.09	0.91	FALSE
25	GTEx	Skin Not Sun Exposed Suprapubic	NOXRED1	0.19	0.14	enet	19	0.18	4.8e-10	-7.6	-7.4	1.6e-13	-0.81	0.04	0.96	FALSE
58	The Cancer Genome Atlas	Soft Tissue Sarcoma	C14orf174	0.04	0.02	enet	10	0.00	1.7e-01	5.8	7.4	1.6e-13	0.83	0.02	0.81	FALSE
18	GTEx	Esophagus Muscularis	NOXRED1	0.10	0.07	lasso	4	0.06	8.8e-05	7.7	-7.3	2.4e-13	-0.93	0.03	0.96	FALSE
36	The Cancer Genome Atlas	Breast Invasive Carcinoma	AHSA1	0.01	0.01	blup	56	0.01	2.9e-03	-7.6	-7.3	3.4e-13	-0.94	0.02	0.80	FALSE
42	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C14orf148	0.03	0.04	lasso	3	0.03	3.1e-04	7.7	-7.2	6.4e-13	-0.89	0.05	0.94	FALSE
7	GTEx	Artery Tibial	TMED8	0.12	0.02	enet	11	0.02	7.7e-03	7.9	7.2	6.7e-13	0.74	0.11	0.73	FALSE
33	METSIM	Adipose	AHSA1	0.03	0.01	blup	586	0.01	9.8e-03	6.8	-7.2	7.2e-13	-0.67	0.02	0.93	FALSE
53	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C14orf174	0.07	0.03	blup	43	0.08	5.8e-06	8.4	7.1	1.7e-12	0.80	0.01	0.98	FALSE
46	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C14orf174	0.02	0.00	blup	43	0.02	4.4e-03	-7.7	7.0	2.3e-12	0.91	0.01	0.76	FALSE
60	The Cancer Genome Atlas	Thyroid Carcinoma	C14orf148	0.03	0.01	enet	8	0.01	5.0e-02	7.7	-6.9	5.3e-12	-0.83	0.03	0.85	FALSE
4	GTEx	Adipose Subcutaneous	NOXRED1	0.14	0.06	lasso	4	0.04	3.3e-04	7.7	-6.9	6.2e-12	-0.89	0.05	0.95	FALSE
8	GTEx	Artery Tibial	NOXRED1	0.08	0.06	lasso	7	0.04	5.0e-04	-7.6	-6.8	9.5e-12	-0.94	0.03	0.96	FALSE
10	GTEx	Breast Mammary Tissue	TMED8	0.18	0.04	enet	16	0.06	4.3e-04	-6.8	6.8	1.1e-11	0.82	0.03	0.94	FALSE
24	GTEx	Prostate	NOXRED1	0.26	0.03	enet	34	0.02	1.1e-01	-7.7	-6.7	1.8e-11	-0.88	0.03	0.88	FALSE
44	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AHSA1	0.02	0.04	blup	56	0.03	1.7e-04	-7.6	-6.4	1.1e-10	-0.94	0.02	0.98	FALSE
47	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C14orf174	0.05	0.04	lasso	2	0.06	3.7e-04	3.6	6.5	1.1e-10	0.80	0.01	0.89	FALSE
43	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ISM2	0.06	0.02	enet	6	0.03	8.3e-05	-2.9	-6.4	1.4e-10	-0.18	0.01	0.83	FALSE
16	GTEx	Esophagus Mucosa	TMED8	0.23	0.09	lasso	8	0.14	8.6e-10	8.4	6.2	5.7e-10	0.85	0.02	0.98	FALSE
39	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	VIPAR	0.07	0.02	enet	9	0.06	5.6e-04	-6.8	6.2	7.1e-10	0.68	0.02	0.70	FALSE
6	GTEx	Artery Aorta	TMED8	0.17	0.06	lasso	8	0.11	1.5e-06	3.2	6.1	1.1e-09	0.82	0.04	0.95	FALSE
37	The Cancer Genome Atlas	Breast Invasive Carcinoma	C14orf148	0.02	0.01	blup	53	0.02	1.1e-04	-7.6	-6.1	1.2e-09	-0.87	0.05	0.90	FALSE
62	The Cancer Genome Atlas	Thyroid Carcinoma	GSTZ1	0.19	0.05	lasso	4	0.12	1.1e-11	-4.4	-5.8	5.7e-09	-0.34	0.93	0.00	FALSE
26	GTEx	Skin Sun Exposed Lower leg	TMED8	0.15	0.12	lasso	7	0.16	8.4e-13	3.1	5.6	1.8e-08	0.66	0.97	0.03	FALSE
9	GTEx	Brain Hypothalamus	GSTZ1	0.35	0.17	lasso	4	0.16	1.5e-04	-4.5	-5.6	2.0e-08	-0.50	0.08	0.36	FALSE
34	METSIM	Adipose	POMT2	0.04	0.00	blup	553	0.00	6.0e-02	4.1	5.3	1.1e-07	0.27	0.15	0.05	FALSE
1	CommonMind	Brain Pre-frontal Cortex	POMT2	0.11	0.01	bslmm	553	0.02	5.2e-04	2.0	-5.3	1.2e-07	-0.58	0.11	0.69	FALSE
31	GTEx	Thyroid	NOXRED1	0.06	0.01	lasso	9	0.00	7.6e-01	-7.6	-5.3	1.4e-07	-0.76	0.03	0.90	FALSE
21	GTEx	Nerve Tibial	TMED8	0.27	0.20	enet	22	0.28	2.7e-20	3.3	5.2	1.6e-07	0.62	1.00	0.00	FALSE