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chr16:49,403,920-51,037,009

Best TWAS P=1.32e-09 · Best GWAS P=2.11e-09 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ADCY7	0.10	0.02	enet	23	0.05	7.8e-07	5.3	-5.8	6.5e-09	0.30	0.12	0.81	TRUE
2	GTEx	Adipose Subcutaneous	HEATR3	0.17	0.19	lasso	8	0.20	2.3e-16	-5.4	5.2	2.2e-07	-0.74	0.13	0.87	FALSE
3	GTEx	Artery Aorta	HEATR3	0.41	0.41	enet	62	0.42	5.4e-25	-5.2	5.3	1.1e-07	-0.67	0.14	0.86	TRUE
4	GTEx	Artery Tibial	HEATR3	0.27	0.31	enet	17	0.32	2.1e-25	-5.4	5.7	1.0e-08	-0.73	0.12	0.88	FALSE
5	GTEx	Brain Cerebellum	HEATR3	0.70	0.66	lasso	7	0.69	1.4e-27	-5.2	5.5	3.4e-08	-0.76	0.17	0.83	FALSE
6	GTEx	Brain Cerebellum	RP11-429P3.3	0.40	0.22	enet	11	0.26	1.9e-08	-5.2	5.9	4.7e-09	-0.83	0.07	0.92	TRUE
7	GTEx	Brain Cortex	HEATR3	0.51	0.46	lasso	11	0.47	8.5e-15	-5.2	5.1	3.0e-07	-0.72	0.15	0.85	FALSE
8	GTEx	Brain Frontal Cortex BA9	HEATR3	0.30	0.20	lasso	10	0.16	5.6e-05	-5.4	5.3	1.0e-07	-0.72	0.06	0.83	FALSE
9	GTEx	Brain Hippocampus	HEATR3	0.27	0.23	enet	9	0.19	3.9e-05	-5.2	5.4	5.7e-08	-0.75	0.06	0.82	FALSE
10	GTEx	Brain Hypothalamus	HEATR3	0.26	0.01	lasso	6	0.01	1.9e-01	-5.2	5.7	1.1e-08	-0.82	0.03	0.73	FALSE
11	GTEx	Brain Nucleus accumbens basal ganglia	HEATR3	0.36	0.20	enet	18	0.24	3.8e-07	-5.4	5.8	7.6e-09	-0.75	0.11	0.88	FALSE
12	GTEx	Breast Mammary Tissue	HEATR3	0.33	0.26	lasso	6	0.25	2.6e-13	-5.4	5.1	3.0e-07	-0.70	0.11	0.88	FALSE
13	GTEx	Colon Sigmoid	HEATR3	0.27	0.32	lasso	5	0.28	1.6e-10	-5.4	5.3	1.1e-07	-0.73	0.12	0.88	FALSE
14	GTEx	Colon Transverse	HEATR3	0.36	0.36	lasso	7	0.36	9.1e-18	-5.4	5.3	1.0e-07	-0.73	0.11	0.89	FALSE
15	GTEx	Esophagus Gastroesophageal Junction	HEATR3	0.36	0.26	lasso	6	0.25	1.7e-09	-5.2	5.4	7.1e-08	-0.77	0.15	0.85	FALSE
16	GTEx	Esophagus Mucosa	HEATR3	0.18	0.16	lasso	11	0.15	2.6e-10	-5.4	5.2	2.2e-07	-0.74	0.13	0.87	FALSE
17	GTEx	Esophagus Muscularis	HEATR3	0.40	0.38	lasso	8	0.39	6.1e-25	-5.4	5.2	2.0e-07	-0.71	0.11	0.89	FALSE
18	GTEx	Heart Atrial Appendage	HEATR3	0.30	0.30	lasso	8	0.27	1.1e-12	-5.2	5.2	1.7e-07	-0.74	0.16	0.84	FALSE
19	GTEx	Heart Left Ventricle	HEATR3	0.29	0.14	enet	25	0.22	8.4e-12	-5.4	5.6	2.2e-08	-0.65	0.13	0.87	TRUE
20	GTEx	Lung	HEATR3	0.34	0.40	enet	19	0.41	6.4e-34	-5.2	5.4	8.5e-08	-0.72	0.15	0.85	TRUE
21	GTEx	Nerve Tibial	RP11-429P3.3	0.18	0.12	enet	13	0.12	1.7e-08	-5.4	5.4	5.7e-08	-0.67	0.12	0.87	FALSE
22	GTEx	Pituitary	HEATR3	0.55	0.36	lasso	7	0.48	1.3e-13	-5.2	5.5	4.3e-08	-0.87	0.05	0.95	TRUE
23	GTEx	Skin Not Sun Exposed Suprapubic	HEATR3	0.22	0.18	lasso	9	0.18	5.0e-10	-5.4	5.2	1.7e-07	-0.72	0.12	0.88	FALSE
24	GTEx	Spleen	HEATR3	0.43	0.13	lasso	9	0.13	2.7e-04	-5.4	5.3	9.8e-08	-0.71	0.07	0.89	TRUE
25	GTEx	Stomach	HEATR3	0.36	0.27	enet	14	0.28	1.6e-13	-4.9	5.7	1.2e-08	-0.81	0.14	0.86	FALSE
26	GTEx	Testis	HEATR3	0.47	0.37	enet	33	0.38	4.5e-18	-5.4	6.0	2.0e-09	-0.76	0.13	0.87	FALSE
27	GTEx	Testis	RP11-429P3.3	0.21	0.03	lasso	5	0.03	1.6e-02	-5.4	5.3	1.1e-07	-0.73	0.07	0.52	FALSE
28	GTEx	Thyroid	HEATR3	0.34	0.37	enet	19	0.37	6.6e-30	-5.2	5.7	9.8e-09	-0.74	0.17	0.83	FALSE
29	GTEx	Whole Blood	RP11-429P3.3	0.08	0.01	enet	12	0.01	2.6e-02	4.2	5.2	2.3e-07	-0.53	0.06	0.75	FALSE
30	METSIM	Adipose	HEATR3	0.18	0.23	lasso	7	0.23	1.9e-33	-5.4	5.5	3.5e-08	-0.74	0.13	0.87	FALSE
31	The Cancer Genome Atlas	Glioblastoma Multiforme	HEATR3	0.13	0.07	blup	39	0.10	5.1e-04	-5.7	5.6	1.7e-08	-0.81	0.02	0.84	FALSE
32	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	HEATR3	0.14	0.04	blup	39	0.08	3.2e-04	-4.9	6.1	1.3e-09	-0.69	0.03	0.51	TRUE
33	The Cancer Genome Atlas	Thyroid Carcinoma	HEATR3	0.16	0.20	blup	39	0.21	6.4e-20	-5.3	5.7	9.3e-09	-0.76	0.10	0.90	TRUE
34	The Cancer Genome Atlas	Thyroid Carcinoma	PAPD5	0.02	0.03	lasso	1	0.02	1.8e-03	-5.6	5.6	1.7e-08	-0.62	0.03	0.72	FALSE