TWAS hub - ADCY7

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1010	0.0300	2.1e-05	0.025	0.042	0.051	0.043	0.034	4.4e-04	6.3e-06	7.8e-07	5.7e-06	4.3e-05
2	GTEx	Cells Transformed fibroblasts	0.1130	0.0440	1.8e-03	0.145	NA	0.104	NA	0.141	5.1e-11	NA	3.2e-08	NA	1.1e-10
3	GTEx	Esophagus Mucosa	0.1750	0.0610	2.4e-03	0.019	NA	0.011	NA	0.057	1.8e-02	NA	6.1e-02	NA	1.1e-04
4	METSIM	Adipose	0.0355	0.0169	1.1e-02	0.000	0.007	0.008	0.008	0.004	2.8e-01	2.4e-02	1.6e-02	1.8e-02	8.0e-02
5	NTR	Blood	0.0746	0.0157	8.1e-14	0.059	0.051	0.066	0.061	0.066	2.7e-18	5.5e-16	2.0e-20	5.8e-19	2.5e-20
6	TCGA	Liver Hepatocellular Carcinoma	0.1000	0.0460	5.9e-04	0.062	0.050	0.015	NA	0.022	7.4e-04	2.1e-03	6.5e-02	NA	3.0e-02
7	TCGA	Prostate Adenocarcinoma	0.0326	0.0183	9.5e-03	0.005	0.017	-0.002	NA	0.002	8.5e-02	6.6e-03	5.7e-01	NA	2.1e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Crohns Disease (2017)	13.7	30.1	67.7	6.0	-5.2	-2.3	-8.2	-5.7	3.5	-5.5
Crohns Disease (2012)	12.6	20.3	35.2	5.9	-4.6	-1.3	-5.3	-4.3	4.7	-4.0
Irritable Bowel Disease (IBD)	8.2	19.5	47.9	2.3	-3.2	-3.4	-6.9	-6.1	1.8	-4.6
Ulcerative Colitis	5.7	8.2	17.1	-2.5	-1.1	-4.0	-3.5	-4.1	-0.8	-2.1
Ulcerative Colitis (UC)	3.8	7.1	14.6	-2.5	-0.1	-3.5	-3.2	-3.8	-1.4	-2.2
Hypothyroidism (self reported)	3.7	8.5	32.8	0.2	-0.2	-2.9	-2.8	-5.7	1.2	-3.0
Mouth/teeth dental problems: Mouth ulcers	3.6	5.7	16.4	-1.4	-0.8	-3.3	-1.7	-4.1	0.3	-2.5
Depression (Nagel 2018)	3.1	4.7	11.2	-0.2	1.5	3.3	2.6	3.1	0.4	1.6
Exposure to tobacco smoke outside home	3.0	4.1	7.8	-0.6	-0.4	-2.0	-2.6	-2.1	-2.8	-2.3
Type 2 Diabetes (T2D) (2012)	2.9	3.3	12.9	0.6	-0.9	-0.0	-1.1	-1.4	-3.6	-2.5
Hypothyroidism/myxoedema (self-reported)	2.9	5.6	20.3	-0.4	-0.0	-2.6	-2.4	-4.5	1.7	-1.8
Illnesses of father: High blood pressure	2.8	3.4	11.6	-1.0	1.7	-1.3	-0.8	-0.7	3.4	2.4
Medication: Levothyroxine sodium	2.7	4.5	15.5	-1.2	0.7	-2.7	-2.0	-3.9	1.3	-1.2
Mean Putamen Volume	2.6	3.0	6.8	-0.2	0.1	-2.1	-1.6	-2.0	-2.6	-1.6
Tinnitus: Yes, but not now, but have in the past	2.6	2.8	8.1	-0.1	-1.1	-2.4	-1.1	-2.8	-0.4	-1.7
Medication: Co-codamol	2.5	2.9	9.2	-1.1	-0.0	-1.7	-2.2	-3.0	0.2	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	2.5	3.3	6.6	-0.4	2.0	2.1	1.8	2.6	0.7	2.0
Frequency of depressed mood in last 2 weeks	2.4	3.3	9.4	0.0	0.6	2.5	2.0	3.1	-0.0	1.7
Smoking Status	2.3	5.4	13.8	-3.7	2.2	-2.9	-1.9	-2.4	-1.1	-0.1
Other serious medical condition/disability diagnosed by doctor	2.2	2.8	7.1	-1.1	1.2	-2.2	-1.9	-2.7	1.2	-0.2
Neuroticism score	2.1	4.3	7.4	1.2	1.9	2.7	1.1	2.5	2.7	1.9
Eye problems/disorders: None of the above	2.1	2.5	8.1	0.1	-0.5	-0.1	-0.9	-1.5	-2.8	-2.4
Happiness	2.0	2.5	7.3	-1.0	1.0	0.9	0.9	1.7	1.8	2.7
Illness, injury, bereavement, stress in last 2 years	2.0	2.5	9.7	2.0	-3.1	1.1	-0.0	1.6	0.1	0.1
Back pain experienced in last month	2.0	2.9	6.1	-1.2	-1.7	-1.1	-1.6	-2.5	1.0	-2.4
Supplements: Zinc	1.9	2.1	5.5	0.1	0.8	0.7	0.4	1.9	2.0	2.3
Financial difficulties in last 2 years	1.9	2.5	11.4	-3.4	2.1	-0.2	0.8	-1.0	0.0	0.4
Shortness of breath walking on level ground	1.9	2.3	6.6	-0.3	-0.8	-1.2	-1.7	-2.6	0.5	-1.9
Alzheimer’s Disease (in father)	1.8	1.9	3.8	1.7	-1.8	-1.4	-2.0	-1.0	-0.5	-0.6
Exposure to tobacco smoke at home	1.8	2.0	5.2	0.4	-0.4	-0.6	-1.2	-1.6	-2.3	-2.0
Hair/balding pattern: Pattern 4	1.8	4.3	12.7	3.6	-1.7	-0.5	-0.9	-1.4	-1.7	-3.0
Illnesses of father: None of the above (group 1)	1.8	2.2	6.2	1.8	-1.2	1.0	0.3	0.1	-2.5	-1.8
Diabetes (father)	1.7	2.1	4.3	1.5	0.5	2.1	1.4	2.0	0.8	1.2
Medication: Omeprazole	1.7	2.1	6.4	-2.5	1.9	-1.6	-0.7	-0.1	0.1	1.3
Number of full sisters	1.7	2.0	7.4	1.8	2.7	-1.5	-0.7	-0.2	-0.3	0.7
Blood White Count	1.6	12.1	33.6	-5.8	4.6	0.7	2.6	2.9	-1.0	3.6
Eye problems/disorders: Diabetes related eye disease	1.6	1.7	7.7	-2.8	0.6	0.1	0.9	1.3	-0.2	1.3
Hair/balding pattern: Pattern 2	1.6	2.0	3.7	1.9	1.4	1.8	0.7	1.5	1.0	1.2
Fluid intelligence score	1.6	3.4	8.5	-2.7	2.1	0.3	1.1	1.0	-2.9	0.9
Impedance of arm (left)	1.6	7.5	18.0	4.0	-4.2	-0.0	-1.3	-1.6	-1.3	-3.5
Illnesses of father: Heart disease	1.6	2.2	5.4	-2.3	1.4	-1.2	0.2	-0.1	2.1	1.5
Lupus	1.5	2.2	5.9	-1.2	0.6	-2.4	-1.5	-1.9	0.9	1.0
Hand grip strength (left)	1.5	3.9	9.5	-2.1	-1.3	-3.1	-1.4	-2.4	-1.5	-1.2
Family relationship satisfaction	1.5	1.8	4.6	-1.9	1.4	-0.5	0.1	0.7	1.3	2.2
Mood swings	1.5	2.8	6.5	-0.1	2.3	-0.2	-0.6	1.4	2.3	2.6
Medication: Gliclazide	1.5	1.7	5.5	-0.6	2.3	0.8	0.3	1.6	-1.3	1.0
Medication: Omeprazole (e.g. Zanprol)	1.5	1.8	6.7	-2.6	1.3	-1.6	-0.6	-0.5	-1.1	0.4
Alzheimer’s Disease (including proxy)	1.4	2.1	5.7	0.9	-0.9	-2.4	-2.1	-1.7	0.1	-0.2
Lung FVC	1.4	7.0	22.6	-4.8	2.0	0.8	2.5	1.1	-3.8	0.5
Depression (self-reported)	1.4	1.7	6.6	1.0	-1.0	1.7	0.6	0.3	2.6	-0.2
Mouth/teeth dental problems: Bleeding gums	1.4	1.9	4.6	0.6	-1.0	2.2	1.9	1.7	0.1	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	3.5	-1.9	0.8	-1.7	-0.7	-1.8	0.5	-0.3
Friendships satisfaction	1.4	1.7	3.8	-1.0	2.0	0.5	0.8	1.2	1.0	1.9
Smoking status: Current	1.4	2.2	5.6	-1.7	0.3	-2.4	-1.7	-1.9	0.0	-0.4
Hearing aid user	1.4	1.5	4.6	0.2	1.5	-0.5	-0.0	0.7	2.1	1.8
Commuting to job workplace: Public transport	1.4	1.6	6.9	-2.6	1.1	0.7	1.6	0.3	-0.2	-0.1
Depressed Affect (Nagel 2018)	1.3	2.8	5.8	0.3	2.0	1.4	1.0	1.7	2.4	1.9
Neuroticism	1.3	3.1	7.4	0.9	2.7	2.2	0.5	1.6	2.0	1.3
Average weekly spirits intake	1.3	1.6	4.2	-2.1	1.1	0.8	2.0	1.1	0.3	0.5
Fed-up feelings	1.3	2.3	5.0	-0.5	1.7	0.9	0.6	1.7	2.2	2.0
Taking other prescription medications	1.3	2.0	7.4	-2.7	1.1	-0.7	-0.6	-0.8	1.9	0.5
Asthma	1.3	2.5	8.0	0.1	-2.1	-0.8	-0.7	-1.4	2.8	-1.4
Breastfed as a baby	1.3	1.6	4.4	1.0	0.7	0.4	1.3	1.8	0.2	2.1
Medication: Ventolin 100micrograms inhaler	1.3	1.7	5.2	1.3	-2.3	-0.1	-1.0	-0.8	1.4	-1.2
Health satisfaction	1.3	1.6	4.0	-0.9	0.7	-2.0	-1.5	-1.7	1.1	0.4
Mouth/teeth dental problems: Loose teeth	1.3	1.5	5.3	-2.3	1.8	0.2	0.6	0.7	-1.0	0.5
Handedness (chirality/laterality): Left-handed	1.3	1.5	4.3	-2.1	1.4	-0.3	-0.3	-0.2	1.5	1.4
Asthma (self-reported)	1.3	2.6	8.9	0.3	-2.0	-1.1	-1.0	-1.4	3.0	-1.1
Ever smoked	1.3	2.2	9.8	-3.1	1.7	-0.7	0.2	0.4	0.1	1.5
Prostate Cancer	1.2	1.6	3.2	0.1	1.8	1.2	1.0	1.4	1.3	1.5
Past tobacco smoking	1.2	2.2	8.7	2.9	-2.1	0.8	0.2	0.1	0.8	-0.9
Nervous feelings	1.2	2.3	5.1	0.5	1.9	1.5	0.6	1.4	2.3	1.5
Hearing difficulty/problems with background noise	1.2	2.0	4.7	-2.2	1.1	-0.5	0.2	0.8	1.6	2.1
Impedance of arm (right)	1.2	5.8	14.1	3.6	-3.8	-0.1	-1.4	-1.3	-0.8	-2.9
Suffer from ‘nerves’	1.2	1.9	4.5	0.3	0.8	2.1	0.3	1.8	1.8	1.1
Leg pain on walking	1.2	1.5	3.1	-1.7	-0.9	-0.4	0.2	-1.8	0.5	-1.7
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	9.2	-3.0	-0.6	-0.2	-0.4	0.1	0.3	0.5
Commuting to job workplace: Car/motor vehicle	1.2	1.4	4.4	2.1	-1.5	0.4	-0.1	0.5	1.6	0.2
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	2.6	-0.5	1.1	-1.1	-1.6	-0.8	1.4	1.2
Impedance of whole body	1.2	5.9	16.3	3.7	-4.0	0.2	-0.7	-1.4	0.0	-3.0
Alzheimer’s Disease (in mother)	1.1	1.3	3.9	0.3	0.0	-2.0	-1.2	-1.4	1.2	0.1
Ovarian Cancer	1.1	1.4	3.3	-1.8	1.3	1.3	0.7	1.3	-0.4	0.9
Primary Biliary Cirrhosis	1.1	1.5	3.8	1.4	0.3	-1.3	-0.7	-1.9	-0.9	-1.4
Triglycerides	1.1	1.7	5.6	-1.0	-1.3	-0.2	0.8	-1.2	-1.4	-2.4
Respiratory disease	1.1	2.4	9.5	0.5	-0.2	-1.4	-1.9	-0.9	3.1	0.6
Hearing difficulty/problems: Yes	1.1	1.7	3.4	-1.5	0.9	0.3	1.1	1.2	1.6	1.8
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.6	5.8	-0.5	-0.9	1.3	1.0	1.9	2.4	2.2
Pain all over the body in last month	1.1	1.2	4.3	-0.6	2.1	-0.3	-0.2	-0.6	1.6	0.7
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	4.4	0.6	0.7	0.7	0.1	1.8	1.2	2.1
High blood pressure (siblings)	1.1	1.5	4.0	-1.6	2.0	-1.1	-0.2	-0.3	0.6	1.5
Long-standing illness, disability or infirmity	1.1	1.6	6.1	-0.6	-0.1	-1.1	-0.5	-1.7	2.5	-0.7
Wears glasses or contact lenses	1.1	1.2	3.8	-0.2	2.0	1.4	1.0	0.8	0.7	0.9
Mother’s age at death	1.1	1.4	4.5	2.1	-1.0	1.1	0.4	0.8	-1.4	-0.6
Supplements: Fish oil (including cod liver oil)	1.1	1.4	4.2	-0.5	-0.5	-1.9	-2.1	-1.4	-0.3	-0.1
Schizophrenia (2018)	1.0	2.0	4.7	-2.2	0.8	-2.1	-1.8	-0.7	-1.1	-0.1
Worry (Nagel 2018)	1.0	2.0	6.2	0.4	1.2	2.5	0.7	1.6	1.6	0.9
Body Mass Index (BMI) (2010)	1.0	1.3	2.9	-0.9	-0.2	-1.2	-0.9	-1.7	-1.3	-1.3
Ever used hormone-replacement therapy (HRT)	1.0	1.2	2.8	-0.5	-0.1	-0.7	-1.5	-1.7	0.5	-1.6
Trunk fat percentage	1.0	4.2	8.2	2.5	-2.2	-0.1	-1.0	-1.2	-2.8	-2.9
Multivitamins +/- minerals	1.0	1.3	3.8	1.9	-0.0	1.6	-0.8	1.2	0.7	0.3
Alcohol usually taken with meals	1.0	1.6	3.5	1.3	-0.1	1.9	1.6	1.5	0.9	0.7
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	3.9	-0.5	1.2	0.1	-1.1	0.9	2.0	1.7
Father’s age at death	1.0	1.4	2.6	1.6	-1.4	1.5	1.0	1.2	0.5	0.2
Medication: Lansoprazole	1.0	1.1	4.2	0.0	-0.0	2.1	1.5	0.6	-0.3	-1.0
Illnesses of mother	1.0	1.2	1.7	-1.0	-0.8	-0.6	-1.3	-1.3	-1.3	-1.1
Pulse wave Arterial Stiffness index	1.0	1.1	2.2	-0.9	1.1	-1.4	-1.0	-1.5	-0.5	-0.8
Birth weight	1.0	2.1	4.5	0.7	-0.8	1.1	2.1	2.1	-1.8	-0.5
Emphysema/chronic bronchitis	1.0	1.1	1.7	0.9	1.3	0.8	-0.1	1.2	1.3	1.2
Smoking status: Previous	1.0	1.4	4.9	-2.2	2.0	-0.3	-0.0	-0.1	-0.8	0.7
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	9.0	-0.1	-3.0	-0.7	-0.8	-1.5	0.1	-1.6
Average weekly red wine intake	1.0	1.5	3.6	-0.6	0.2	0.5	1.3	1.3	1.8	1.9
Loneliness, isolation	1.0	1.4	3.0	0.4	1.4	1.0	0.9	1.0	1.7	1.2
Number of self-reported non-cancer illnesses	1.0	1.8	7.5	-0.7	-0.6	-0.4	-0.9	-1.6	2.7	-0.6
Miserableness	1.0	1.7	5.4	0.8	0.1	1.3	1.3	1.4	2.3	0.9
Medication: Paracetamol	1.0	1.6	7.3	2.7	-1.1	0.9	0.7	0.5	0.4	-1.0
Ever had prostate specific antigen (PSA) test	1.0	1.2	3.4	0.0	-0.9	-0.9	-1.3	-1.9	-0.2	-1.2
Bipolar Disorder (2018)	0.9	1.5	4.2	1.0	-2.0	0.7	1.1	-0.1	0.1	-1.9
Sensitivity / hurt feelings	0.9	1.5	5.2	2.3	0.8	1.9	0.5	0.5	0.5	-0.3
Medication: Metformin	0.9	1.3	4.6	-1.6	2.1	-0.0	0.3	0.4	0.7	1.0
Hand grip strength (right)	0.9	2.5	5.5	-1.6	-0.7	-2.4	-0.7	-2.1	-1.5	-1.2
Current tobacco smoking	0.9	1.5	3.8	-1.7	0.4	-2.0	-1.3	-1.5	0.1	-0.2
Chronic bronchitis/emphysema (father)	0.9	1.1	2.1	-0.9	1.4	-1.1	-0.9	0.1	0.9	1.5
Had menopause	0.9	1.2	2.8	-1.1	0.1	-1.1	-1.4	-1.7	-0.3	-0.9
Had other major operations	0.9	1.1	3.9	-1.1	0.7	-0.5	0.2	0.3	2.0	1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	5.5	-0.6	-0.1	1.0	0.3	1.4	2.4	2.2
Mouth/teeth dental problems: Dentures	0.9	1.5	3.5	-1.6	1.9	0.3	0.4	-0.3	-1.7	-1.0
Length of working week for main job	0.9	1.0	3.4	-0.2	0.2	-1.8	-1.2	-0.1	-0.5	1.4
Qualifications: College or University degree	0.9	3.0	8.9	1.0	-1.0	1.9	1.9	3.0	-0.7	1.6
Medication: Aspirin	0.9	1.2	2.1	-0.1	1.2	1.3	1.4	1.4	0.5	0.9
Average weekly beer plus cider intake	0.9	1.3	5.4	0.5	-2.3	0.1	-0.3	-0.8	1.1	-1.3
Irritability	0.9	1.5	3.2	0.5	1.4	1.7	0.5	1.8	1.0	0.7
Pack years of smoking	0.9	1.4	4.6	0.3	-0.2	-0.6	-2.1	-1.8	-0.1	-1.1
Neuroticism (Nagel 2018)	0.8	1.9	4.3	0.4	1.8	2.1	0.3	1.5	1.6	0.9
Schizophrenia vs Biploar Disorder	0.8	1.0	5.0	-0.0	2.2	-0.2	-0.7	-0.2	-0.8	0.9
Breast Cancer	0.8	2.0	4.2	1.0	-1.7	2.1	1.4	0.7	0.3	-1.7
Coronary Artery Disease (CAD)	0.8	1.0	3.0	-1.7	-0.4	-0.8	0.1	-1.7	0.0	0.0
Angina	0.8	1.1	3.0	-0.0	-0.9	1.7	1.7	0.8	0.2	-0.3
Vitamin and mineral supplements	0.8	1.1	4.8	-2.2	0.7	0.0	1.4	0.2	-0.7	-0.0
Pack years adult smoking proportion	0.8	1.3	3.7	0.3	-0.4	-0.7	-1.9	-1.8	0.3	-1.0
Qualifications: CSEs or equivalent	0.8	1.0	3.0	1.7	-1.5	-0.3	-1.0	-0.3	0.9	-0.3
Serious illness, injury or assault to yourself	0.8	0.9	2.5	-0.6	1.0	-0.9	-0.3	-1.6	-1.0	-0.8
Forced vital capacity (FVC)	0.8	3.0	12.8	-2.8	-0.2	-0.3	0.5	-0.0	-3.6	-0.2
Heart attack	0.8	1.0	2.2	0.8	-1.1	-0.3	-0.4	-0.9	-1.5	-1.5
Alcohol intake versus 10 years previously	0.8	1.2	4.2	0.6	-0.5	-0.9	-2.0	-1.4	-0.1	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.1	3.3	1.8	-0.7	-0.7	-1.8	0.1	-0.1	0.1
Glaucoma (self-reported)	0.8	0.9	2.1	0.9	0.3	0.4	-0.5	1.3	1.1	1.4
Age at first live birth	0.8	1.4	4.5	2.1	-1.7	1.1	0.2	0.6	-0.3	-0.6
Medication: Seretide 50 evohaler	0.8	1.0	1.6	1.3	-1.2	0.9	0.9	0.1	1.2	-0.8
Diabetes diagnosed by doctor	0.8	1.3	5.2	-2.3	1.6	-0.1	-0.7	-0.8	0.4	-0.6
Guilty feelings	0.8	1.2	3.4	0.0	1.6	1.8	-0.0	1.0	1.1	0.7
Eye problems/disorders: Glaucoma	0.8	1.0	2.5	-0.5	0.5	0.0	-0.2	1.5	1.3	1.6
Medication: Bendroflumethiazide	0.8	1.2	3.2	0.8	0.3	-1.0	-1.7	-1.8	-0.7	-0.6
Supplements: Calcium	0.8	0.9	3.1	-0.5	-0.2	0.8	0.3	0.9	1.8	1.1
Verbal and Numeric Reasoning (VNR)	0.7	1.7	5.6	-1.4	1.7	0.4	0.7	0.9	-2.4	0.2
Blood Platelet Count	0.7	8.1	23.4	-3.2	4.8	0.2	2.6	2.2	-0.9	3.2
Medication for hormone replacement therapy	0.7	0.7	1.7	0.5	-1.2	0.8	0.7	1.3	0.8	0.4
Diabetes (mother)	0.7	0.8	3.5	1.9	-0.5	-1.2	0.2	-0.7	0.3	-0.2
Impedance of leg (left)	0.7	3.5	9.5	3.0	-3.1	0.6	0.0	-1.0	1.0	-1.9
Trunk fat mass	0.7	3.0	7.2	1.4	-1.7	-0.6	-1.3	-1.3	-2.7	-2.3
Number of live births	0.7	1.0	2.2	-0.4	-0.3	-1.5	-1.1	-1.3	1.3	0.2
Prospective memory result	0.7	0.9	2.0	-0.7	0.6	-1.3	-1.4	-1.2	0.8	0.2
Standing height	0.7	7.3	14.5	-0.4	-3.8	-3.6	-3.1	-3.4	-0.2	-1.7
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	3.3	-0.2	-1.8	0.3	0.1	-0.5	-1.6	-1.3
Body fat percentage	0.7	2.9	7.4	2.0	-1.5	0.1	-0.6	-0.7	-2.7	-2.4
Migraine (self-reported)	0.7	0.9	3.0	1.7	1.0	0.7	-1.1	0.8	-0.3	0.0
Medication: Ibuprofen	0.7	0.9	2.7	1.4	-0.6	-1.0	-1.6	-0.2	0.1	-0.2
Mineral and other dietary supplements	0.7	0.9	2.3	0.5	0.1	1.5	1.2	1.3	-0.6	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	2.7	-1.6	-1.0	1.1	1.3	1.4	-1.2	0.3
Average weekly champagne plus white wine intake	0.7	1.0	3.1	0.1	-0.9	0.8	1.8	0.1	-1.2	-1.0
Ever taken oral contraceptive pill	0.7	0.8	2.3	0.4	-1.0	0.4	-0.7	-0.9	-0.8	-1.5
Commuting to job workplace: Cycle	0.7	0.8	4.0	-2.0	0.7	-1.0	0.0	-0.5	-0.2	0.2
Heart disease (siblings)	0.7	0.8	4.7	-0.4	2.2	0.4	0.0	0.4	0.2	0.6
Major Depression (MDD)	0.6	0.7	3.1	-1.1	-0.3	-0.5	-0.4	-0.1	1.8	0.6
Impedance of leg (right)	0.6	2.7	7.2	2.7	-2.6	0.9	0.5	-0.4	1.5	-1.2
Age when periods started (menarche)	0.6	1.4	8.6	2.9	-0.9	0.2	-0.2	0.3	0.4	-0.5
Supplements: Glucosamine	0.6	0.8	1.9	-0.6	-0.1	-1.1	-1.4	-1.2	0.5	-0.5
Medication: Atenolol	0.6	0.7	1.7	-0.4	-0.1	1.3	1.2	0.1	-1.2	-0.5
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	2.3	0.5	0.0	1.2	1.5	1.0	0.4	-0.1
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	7.7	-2.1	-0.7	-0.1	1.0	0.4	-2.8	0.1
Pulse rate	0.6	1.0	2.8	0.3	1.5	-1.1	-0.5	0.4	0.4	1.7
Medication: Cholesterol lowering	0.6	0.9	3.7	-0.0	-0.2	1.9	1.2	1.1	-0.3	0.2
Birth weight of first child	0.6	1.0	3.3	-0.3	1.1	0.9	0.6	1.1	-1.8	0.3
Blood clot in the leg (DVT)	0.6	0.7	2.3	0.3	0.0	-0.8	-0.4	-1.3	1.5	-0.5
Medication: Paracetamol	0.6	1.0	5.9	2.4	-0.2	-0.1	-0.1	0.4	0.9	-0.0
Forced vital capacity (FVC), Best measure	0.6	2.1	7.6	-2.8	-0.4	-0.1	0.6	0.0	-2.5	0.3
Pulse wave peak to peak time	0.6	0.7	1.5	0.7	-1.2	0.8	0.6	1.1	0.5	0.7
Neck or shoulder pain in last month	0.6	0.9	3.5	-0.7	-0.7	1.2	0.2	-0.4	-0.2	-1.9
Angina (self-reported)	0.6	0.8	2.2	0.0	-1.1	1.3	1.5	0.7	0.5	-0.2
Mean time to correctly identify matches	0.6	1.2	5.1	-2.2	1.4	0.5	0.6	0.5	-0.7	0.5
Heart disease (mother)	0.6	0.7	2.4	0.3	0.2	1.3	0.8	1.6	0.2	0.1
Had major operations	0.6	0.7	2.9	1.7	0.2	-0.4	-1.1	-0.7	-0.4	-0.3
Supplements: Vitamin C	0.6	0.7	2.0	1.0	-1.4	0.1	-0.4	0.3	1.3	0.3
Knee pain experienced in last month	0.6	1.0	3.0	-0.5	-1.7	-0.6	-0.8	-0.4	1.6	-0.0
Arm fat percentage (left)	0.6	2.4	9.7	1.6	-0.5	0.2	-0.7	-0.3	-3.1	-1.9
Financial situation satisfaction	0.6	0.8	2.9	-1.7	0.7	-1.0	-0.6	-0.5	0.3	0.4
Number of operations (self-reported)	0.6	1.0	4.6	-0.8	-0.5	-0.6	0.1	-0.5	2.2	0.8
Myopia	0.6	0.9	2.6	0.9	-0.5	1.6	1.1	1.1	0.3	0.1
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.0	0.7	-1.0	-0.2	-0.2	-0.8	-1.3	-1.4
Alcohol drinker status: Previous	0.6	0.6	1.3	0.3	0.8	1.0	0.7	1.1	-1.0	0.3
Intelligence (Savage-Jansen 2018)	0.5	1.6	5.2	-1.7	1.7	-0.4	-0.5	0.1	-2.3	0.1
Age at First Birth	0.5	0.7	1.8	0.8	0.6	-0.2	-1.3	-1.2	0.0	-0.8
HbA1C	0.5	0.5	1.2	-0.5	-0.1	1.0	0.4	1.1	0.8	0.7
Neuroticism (2016)	0.5	0.7	2.5	-0.1	1.0	0.8	0.2	1.6	-0.2	0.8
Rheumatoid Arthritis	0.5	0.7	2.5	-0.8	-0.2	0.1	0.3	-0.8	-1.6	-1.2
Height	0.5	9.1	17.6	-0.2	-3.7	-3.9	-3.5	-4.2	0.3	-2.0
Relative age voice broke	0.5	0.8	2.7	0.1	-0.4	0.8	0.0	0.8	1.7	1.0
High blood pressure	0.5	1.5	4.5	-2.0	0.9	-0.5	-0.6	-2.1	-0.0	-0.7
Stomach or abdominal pain in last month	0.5	0.7	1.7	0.1	-1.3	1.3	-0.5	0.2	0.8	-0.6
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.4	-1.0	-1.0	-0.1	1.2	0.3	0.6	0.2
High blood pressure (mother)	0.5	0.8	1.5	-0.2	0.9	0.9	1.2	1.0	0.4	1.0
Mouth/teeth dental problems	0.5	0.8	2.2	1.5	-0.2	0.1	-0.8	0.4	0.8	1.5
Allergy	0.5	1.1	4.2	-0.2	0.2	0.5	1.6	0.7	-2.0	0.4
Medication: Simvastatin	0.5	0.7	1.3	-1.0	-0.6	1.1	0.3	0.4	-0.6	-1.1
Illnesses of siblings	0.5	0.7	2.3	1.5	-1.0	0.0	-0.9	-0.4	-0.1	-0.9
Arm fat percentage (right)	0.5	2.0	8.3	1.6	-0.4	0.2	-0.6	-0.1	-2.9	-1.7
Time employed in main current job	0.5	0.6	1.0	1.0	-0.3	-0.7	-1.0	-0.9	-0.9	-0.5
Falls in the last year	0.5	0.7	4.1	-0.7	-0.1	0.2	0.0	0.1	2.0	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	6.2	-2.0	-1.1	-0.3	0.7	-0.1	-2.5	-0.3
Tense / ‘highly strung’	0.5	0.8	3.1	1.8	1.0	0.8	-0.7	0.2	0.1	0.2
Peak expiratory flow (PEF)	0.5	1.1	2.9	-1.7	0.2	-0.0	0.7	0.9	-1.6	1.1
Chronic bronchitis/emphysema (mother)	0.5	0.5	2.3	-1.5	0.8	-0.3	0.3	-0.7	0.4	-0.2
Number of children fathered	0.5	0.6	2.0	0.1	1.4	0.3	0.8	0.7	-0.6	0.7
Medication for pain relief, constipation, heartburn	0.5	0.8	2.0	-1.4	-1.0	0.8	0.9	-0.8	0.0	-0.9
Whole body fat mass	0.5	2.1	7.1	1.1	-1.0	-0.5	-1.0	-0.9	-2.7	-1.7
Pulse rate, automated reading	0.5	1.7	3.5	-1.7	1.9	-1.6	-0.4	0.1	-0.4	1.5
Comparative height size at age 10	0.5	2.8	8.6	-1.3	-1.4	-2.9	-1.9	-1.9	-0.3	0.1
Age at last live birth	0.5	0.7	3.2	0.9	-1.8	-0.2	0.4	-0.3	0.7	-0.2
Medication: Aspirin	0.5	0.6	1.2	-0.5	1.1	0.4	0.7	0.9	0.6	1.0
Hypertension (Self-reported)	0.5	1.4	4.0	-2.0	1.4	-0.3	-0.5	-1.8	-0.5	-0.4
Qualifications: nursing, teaching	0.5	0.8	3.2	-0.7	0.2	-0.7	-1.2	-1.8	0.5	-0.3
Commuting to job workplace: Walk	0.5	0.5	2.0	-1.4	0.3	0.5	0.8	0.6	-0.7	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.7	-1.3	0.2	-0.7	-0.6	-0.9	0.6	-0.4
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.1	0.1	-1.4	-0.1	-0.4	-0.6	0.9	-1.0
Medication: Blood pressure	0.5	1.0	2.3	-0.9	0.6	-0.8	-0.7	-1.5	-1.2	-1.1
Medication: Lisinopril	0.5	0.7	2.0	-0.3	0.8	0.4	0.9	-0.4	-1.4	-1.0
Age started oral contraceptive pill	0.5	0.7	2.6	-0.7	-0.6	0.5	-0.7	-0.3	-0.6	-1.6
Ever depressed for a whole week	0.5	0.6	1.8	0.2	0.3	1.1	0.4	1.4	-0.6	0.6
Pain experienced in last month	0.5	0.8	2.6	0.9	-0.1	-0.1	1.5	0.2	-1.6	0.0
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	2.0	0.3	0.2	-0.5	-0.2	-1.2	1.4	-0.5
Reaction Time	0.4	0.8	4.2	-2.1	0.5	0.1	0.2	0.2	-0.8	0.4
Fasting Glucose	0.4	0.5	2.8	1.7	0.4	-0.5	0.1	0.1	-0.4	-0.4
HDL Cholesterol	0.4	0.7	2.3	1.5	0.4	0.4	-0.5	0.7	0.6	1.2
BMI	0.4	2.2	6.8	-0.3	2.6	-0.6	-1.3	-0.1	-2.5	0.3
Waist Hip Ratio (WHR)	0.4	1.7	8.6	-2.9	-0.1	-0.0	1.1	-0.6	1.2	0.6
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.6	-1.0	0.1	-0.3	-1.3	-1.0	0.8	-0.6
Number of treatments/medications taken	0.4	0.8	1.4	-0.5	-0.5	-0.8	-1.2	-1.1	1.1	-0.5
Systolic blood pressure, automated reading	0.4	1.0	5.2	-2.3	0.9	0.2	0.5	0.2	-0.3	0.9
Severe depression (siblings)	0.4	0.4	1.3	0.5	-0.4	0.7	-0.3	0.0	-1.1	-0.8
Townsend deprivation index at recruitment	0.4	0.5	1.1	-0.6	0.2	0.9	0.4	1.0	-1.0	-0.4
Maternal smoking around birth	0.4	0.6	1.4	-0.6	1.2	-0.6	-1.1	-0.6	0.0	0.6
Sitting height	0.4	3.0	6.7	-2.6	-2.1	-2.2	-0.4	-2.0	0.5	-0.6
Number of incorrect matches in round	0.4	0.6	1.9	-0.6	-0.6	-1.4	-0.9	-0.4	0.7	-0.0
Diabetes (self-reported)	0.4	0.6	1.8	-1.3	1.3	0.8	0.2	0.3	0.2	-0.2
Trunk fat-free mass	0.4	2.1	5.8	-2.4	0.8	-2.0	-1.3	-0.8	-0.5	1.2
Trunk predicted mass	0.4	2.0	5.8	-2.4	0.8	-2.0	-1.2	-0.7	-0.4	1.3
Medication: Amlodipine	0.4	0.6	1.6	-0.5	1.2	1.0	0.1	0.1	-1.1	-0.6
Worry too long after embarrassment	0.4	0.7	2.5	0.3	1.1	1.6	0.5	1.0	-0.1	-0.0
Medication: Blood pressure	0.4	0.6	2.2	-1.5	-0.1	0.5	0.5	-1.0	-0.7	-0.5
Chest pain or discomfort	0.4	0.5	3.2	-0.0	-0.5	-0.0	0.1	-0.0	1.8	0.6
Eye problems/disorders: Cataract	0.4	0.5	1.0	0.2	-0.8	-0.1	0.3	0.7	1.0	1.0
Medication for cholesterol	0.4	0.6	1.1	0.1	-0.5	0.7	1.0	1.0	1.0	0.8
Osteoporosis (self-reported)	0.4	0.5	1.3	0.6	-0.4	0.9	-0.7	-0.0	0.6	-1.1
Risk taking	0.4	0.5	1.4	-0.5	0.9	-0.2	0.3	1.1	0.2	1.2
Vascular/heart problems diagnosed by doctor	0.4	1.1	3.7	1.6	-0.6	0.2	0.6	1.9	-0.1	0.8
Basal cell carcinoma (self-reported)	0.4	0.5	1.2	-1.1	0.3	0.7	1.0	0.3	0.6	0.4
Bipolar Disorder or Schizophrenia	0.3	0.8	1.6	-1.1	-0.7	-1.2	-0.4	-0.6	-0.8	-1.3
Heel T-Score	0.3	2.4	6.8	-1.6	-2.6	0.5	1.1	0.6	2.0	1.3
Allergy or Eczema	0.3	0.7	1.7	-0.1	0.8	0.5	-1.3	1.3	-0.5	0.8
Cardiovascular Disease	0.3	0.9	2.9	-1.4	0.7	-0.2	-0.8	-1.7	-0.2	-0.5
Lung FEV1/FVC ratio	0.3	1.7	4.5	2.1	-1.9	-0.8	-1.0	-0.2	-0.8	-1.1
Chronotype (morning person)	0.3	0.8	4.8	-2.2	-0.6	0.0	-0.2	-0.4	-0.1	-0.4
Relative age of first facial hair	0.3	0.5	2.5	0.0	-0.1	0.2	-0.3	0.6	1.6	1.0
Leg fat-free mass (left)	0.3	1.4	3.3	-0.7	-0.3	-1.8	-1.8	-1.0	-1.4	-0.2
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.3	-0.7	-0.2	-0.6	0.2	0.4	0.3	1.1
Leg predicted mass (left)	0.3	1.4	3.3	-0.6	-0.2	-1.8	-1.8	-0.9	-1.4	-0.1
Qualifications: None of the above	0.3	0.7	2.6	1.0	1.6	-0.9	-0.5	-0.2	0.3	0.1
Hip circumference	0.3	1.5	7.3	-0.4	-0.0	-1.1	-1.0	-0.4	-2.7	-0.7
Worrier / anxious feelings	0.3	0.6	1.3	-0.5	0.3	0.8	-0.5	0.8	1.2	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	3.0	0.4	0.2	0.2	-0.7	-0.1	1.7	-0.2
Noisy workplace	0.3	0.4	2.4	1.6	-0.2	-0.0	-0.5	0.2	0.5	-0.1
Arm fat mass (right)	0.3	1.1	5.0	0.5	-0.2	-0.5	-1.0	-0.4	-2.2	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.5	-1.2	0.5	0.7	-0.1	0.5	0.6	-0.2
Pulse wave reflection index	0.3	0.4	1.1	-0.1	0.4	0.9	0.6	-0.4	1.0	-0.4
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.3	-0.4	0.8	1.1	0.0	0.5	0.8	0.1
Headache pain in last month	0.3	0.6	1.8	1.3	0.4	-0.0	-0.9	0.6	0.5	0.8
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.8	0.4	-0.1	-1.3	-1.1	-0.4	0.2	-0.2
Arm fat-free mass (right)	0.3	1.7	5.2	-2.3	0.2	-2.0	-1.1	-1.1	-0.2	0.7
Comparative body size at age 10	0.3	0.9	1.8	0.2	1.2	-0.1	1.3	-0.6	-1.2	-1.1
Number of full brothers	0.3	0.3	1.5	0.3	0.2	0.3	0.6	-0.5	-0.3	-1.2
Wheeze or whistling in the chest in last year	0.3	0.5	2.4	-0.3	-0.6	0.7	-0.2	0.0	1.5	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.0	0.4	0.3	1.0	0.8	0.8	-0.4	-0.0
Arm predicted mass (right)	0.3	1.7	4.3	-2.0	0.4	-2.1	-1.2	-1.0	-0.2	0.9
Alcohol intake frequency.	0.3	0.8	2.2	1.3	0.5	-0.2	-0.7	0.9	-1.5	-0.1
Overall health rating	0.3	0.7	3.1	-1.8	0.7	-0.3	-0.2	-0.8	0.9	-0.0
Whole body fat-free mass	0.3	1.7	4.2	-1.7	0.3	-2.1	-1.5	-1.0	-0.8	0.6
Leg fat-free mass (right)	0.3	1.8	4.2	-0.8	-0.2	-2.1	-2.0	-1.1	-1.5	-0.1
Osteoarthritis (self-reported)	0.3	0.4	1.0	-1.0	0.9	0.3	-0.3	-0.7	-0.0	-0.8
Whole body water mass	0.3	1.8	4.7	-1.9	0.3	-2.2	-1.5	-1.1	-0.7	0.7
Leg predicted mass (right)	0.3	1.7	4.0	-0.8	-0.3	-2.0	-1.9	-1.1	-1.3	-0.1
Arm fat mass (left)	0.3	1.2	5.9	0.6	-0.0	-0.5	-0.9	-0.4	-2.4	-1.0
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.1	-0.7	-0.3	-0.5	-1.0	-0.4	0.6	-0.1
Leg fat percentage (left)	0.3	1.2	5.0	1.1	-0.3	0.0	-0.3	-0.3	-2.2	-1.4
Arm fat-free mass (left)	0.3	1.5	4.0	-1.9	0.5	-2.0	-1.0	-0.7	-0.1	1.2
Unable to work because of sickness or disability	0.3	0.4	1.9	-0.1	0.0	1.4	-0.4	-0.3	0.7	-0.3
Leg fat mass (left)	0.3	1.2	5.2	0.8	-0.3	-0.5	-0.9	-0.6	-2.3	-1.2
Arm predicted mass (left)	0.3	1.6	4.4	-2.0	0.4	-2.1	-1.0	-0.7	-0.2	1.1
Schizophrenia (2014)	0.2	0.4	1.6	-1.3	0.4	-0.4	-0.8	0.2	-0.2	-0.2
Blood Red Count	0.2	1.5	4.7	-0.0	1.1	-0.8	0.4	1.3	1.5	2.2
Systolic Blood Pressure	0.2	0.8	2.2	-1.5	-1.1	0.7	1.2	-0.1	0.4	-0.0
Ever had hysterectomy (womb removed)	0.2	0.2	1.0	-1.0	-0.1	0.1	0.2	-0.1	-0.3	0.6
Average weekly fortified wine intake	0.2	0.3	0.9	-0.9	-0.9	-0.1	0.4	0.1	-0.4	-0.2
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.1	-0.1	0.2	0.3	-1.1	0.9	0.4	0.5
Body mass index (BMI)	0.2	0.9	4.3	-0.1	1.2	0.4	0.2	0.8	-2.1	-0.0
Waist circumference	0.2	0.7	3.3	-0.7	-0.2	-0.4	-0.1	-0.4	-1.8	-1.0
Medication: Ramipril	0.2	0.3	1.0	-1.0	-0.8	-0.2	-0.0	-0.6	0.5	0.1
Weight	0.2	1.2	4.5	-0.3	-0.6	-1.1	-1.0	-0.7	-2.1	-0.8
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.5	-0.3	-0.5	0.4	0.5	0.5	0.5	1.2
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	1.2	-0.3	1.1	-0.5	0.2	-0.4	0.3	0.4
Gout (self-reported)	0.2	0.3	0.6	-0.2	-0.8	0.2	0.6	-0.3	-0.4	-0.8
Leg fat percentage (right)	0.2	0.8	3.4	1.2	-0.2	0.5	0.1	0.2	-1.9	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.3	-0.3	0.6	1.1	0.0	0.6	-0.1	-0.1
Leg fat mass (right)	0.2	0.9	4.2	0.8	-0.2	-0.3	-0.7	-0.2	-2.0	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.8	0.1	0.9	0.4	0.0	0.5	-0.6	-0.1
Breast cancer (self-reported)	0.2	0.2	0.6	-0.5	0.3	-0.8	-0.7	-0.2	-0.3	-0.0
High cholesterol (Self-reported)	0.2	0.4	1.6	-1.3	-0.5	-0.0	-0.4	-0.5	0.7	-0.2
Medication: Atorvastatin	0.2	0.2	0.5	-0.7	0.1	-0.3	-0.3	-0.4	0.7	0.3
Basal metabolic rate	0.2	1.4	3.6	-1.4	0.0	-1.9	-1.4	-0.9	-0.9	0.3
Fractured/broken bones in last 5 years	0.2	0.3	0.6	-0.7	-0.8	0.2	-0.2	0.4	0.3	-0.8
Cholesterol lowering medication	0.2	0.3	0.6	-0.6	-0.7	-0.6	-0.5	-0.5	-0.1	-0.7
Bipolar Disorder (2011)	0.1	0.1	0.3	0.4	0.0	0.1	0.0	-0.6	0.0	0.0
LDL Cholesterol	0.1	0.2	0.9	-0.1	0.1	0.2	1.0	0.7	-0.1	-0.3
Blood Eosinophil Count	0.1	0.8	2.9	-1.7	0.9	0.5	0.5	0.7	-0.8	0.5
Tanning	0.1	1.8	5.9	-1.4	1.4	-1.4	-0.0	-0.4	0.7	2.4
Hair/balding pattern: Pattern 3	0.1	0.2	0.6	-0.2	-0.8	0.1	-0.5	-0.4	-0.4	-0.5
Lung cancer (father)	0.1	0.1	0.4	0.3	-0.1	0.4	-0.5	-0.1	-0.6	-0.0
Loud music exposure frequency	0.1	0.1	0.3	-0.3	-0.5	0.2	-0.2	-0.2	0.3	-0.0
Medication: Allopurinol	0.1	0.2	0.5	-0.3	-0.1	0.4	0.7	0.2	-0.5	-0.1
Illnesses of siblings: Diabetes	0.1	0.1	0.3	-0.4	-0.4	-0.3	0.6	-0.2	-0.4	0.1
Ever had bowel cancer screening	0.1	0.2	0.5	0.3	0.5	-0.1	-0.2	-0.7	0.5	-0.1
Alcohol drinker status: Never	0.1	0.1	0.2	-0.1	0.2	-0.5	-0.5	0.1	0.3	-0.2
Diastolic blood pressure, automated reading	0.1	0.2	0.6	0.3	-0.2	-0.1	-0.5	0.0	-0.7	0.7
Hair Pigment	0.0	0.7	1.8	1.3	-0.9	-0.4	-0.5	0.1	1.3	-0.5

Hub : Genes

ADCY7

Models

Trait associations