Best TWAS P=6.43e-13 · Best GWAS P=6.43e-17 conditioned to 1.81e-07
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | CTC1 | 0.26 | 0.07 | enet | 22 | 0.08 | 6.9e-07 | -6.3 | 5.4 | 7.7e-08 | -0.03 | 0.81 | 0.19 | FALSE |
2 | GTEx | Adipose Subcutaneous | RP11-849F2.8 | 0.16 | 0.08 | lasso | 9 | 0.07 | 3.5e-06 | -6.3 | 6.7 | 2.7e-11 | -0.07 | 0.55 | 0.42 | FALSE |
3 | GTEx | Adipose Visceral Omentum | RP11-849F2.8 | 0.16 | 0.00 | lasso | 9 | 0.01 | 1.4e-01 | -4.8 | 6.8 | 9.4e-12 | -0.06 | 0.04 | 0.76 | FALSE |
4 | GTEx | Artery Tibial | RP11-849F2.8 | 0.09 | 0.04 | lasso | 5 | 0.05 | 1.2e-04 | -4.8 | 5.9 | 4.1e-09 | -0.06 | 0.84 | 0.10 | FALSE |
5 | GTEx | Brain Caudate basal ganglia | RP11-199F11.2 | 0.41 | 0.05 | lasso | 6 | 0.13 | 1.3e-04 | -2.2 | 5.8 | 7.4e-09 | -0.39 | 0.05 | 0.28 | FALSE |
6 | GTEx | Colon Transverse | LSMD1 | 0.28 | 0.12 | lasso | 5 | 0.19 | 3.3e-09 | 4.5 | 5.7 | 1.4e-08 | 0.12 | 0.98 | 0.00 | FALSE |
7 | GTEx | Colon Transverse | RP11-849F2.8 | 0.18 | 0.12 | enet | 25 | 0.10 | 2.5e-05 | -6.4 | 5.2 | 1.9e-07 | -0.09 | 0.58 | 0.37 | FALSE |
8 | GTEx | Lung | CTC1 | 0.16 | 0.09 | lasso | 7 | 0.12 | 9.9e-10 | -5.6 | 5.5 | 3.2e-08 | -0.04 | 0.98 | 0.02 | FALSE |
9 | GTEx | Lung | RP11-849F2.8 | 0.12 | 0.08 | lasso | 5 | 0.09 | 1.2e-07 | -4.1 | 5.3 | 1.4e-07 | -0.06 | 0.94 | 0.06 | FALSE |
10 | GTEx | Nerve Tibial | RP11-849F2.8 | 0.22 | 0.09 | enet | 30 | 0.13 | 3.3e-09 | -4.1 | 7.1 | 1.7e-12 | -0.03 | 0.88 | 0.10 | FALSE |
11 | GTEx | Stomach | RP11-849F2.8 | 0.16 | 0.01 | enet | 19 | 0.04 | 7.9e-03 | -7.3 | 6.4 | 1.2e-10 | -0.04 | 0.04 | 0.72 | FALSE |
12 | GTEx | Testis | CYB5D1 | 0.37 | 0.12 | lasso | 4 | 0.12 | 4.2e-06 | 5.6 | 5.1 | 3.0e-07 | 0.09 | 0.98 | 0.00 | FALSE |
13 | GTEx | Whole Blood | CTC1 | 0.13 | 0.09 | lasso | 8 | 0.09 | 8.6e-09 | -6.3 | 6.8 | 8.5e-12 | -0.08 | 0.95 | 0.05 | FALSE |
14 | GTEx | Whole Blood | RP11-849F2.8 | 0.10 | 0.06 | lasso | 8 | 0.05 | 1.6e-05 | -5.5 | 5.9 | 2.9e-09 | -0.06 | 0.94 | 0.05 | FALSE |
15 | METSIM | Adipose | CTC1 | 0.13 | 0.07 | enet | 25 | 0.08 | 5.8e-12 | -6.3 | 5.4 | 6.1e-08 | -0.05 | 0.96 | 0.04 | FALSE |
16 | METSIM | Adipose | RP11-849F2.8 | 0.13 | 0.11 | lasso | 3 | 0.11 | 3.2e-16 | -5.5 | 5.7 | 1.4e-08 | -0.05 | 0.99 | 0.01 | FALSE |
17 | NTR | Blood | C17orf68 | 0.03 | 0.03 | lasso | 3 | 0.03 | 3.9e-11 | -5.6 | 5.4 | 5.6e-08 | -0.04 | 1.00 | 0.00 | FALSE |
18 | ROSMAP | Brain Pre-frontal Cortex | VAMP2 | 0.20 | 0.17 | bslmm | 412 | 0.20 | 1.7e-25 | -4.1 | 5.6 | 2.2e-08 | -0.08 | 1.00 | 0.00 | FALSE |
19 | YFS | Blood | ACAP1 | 0.33 | 0.21 | enet | 34 | 0.29 | 1.1e-96 | -8.4 | 6.9 | 5.0e-12 | -0.85 | 0.00 | 1.00 | TRUE |
20 | YFS | Blood | CYB5D1 | 0.28 | 0.19 | bslmm | 488 | 0.24 | 5.9e-79 | 5.6 | -6.6 | 4.0e-11 | -0.10 | 1.00 | 0.00 | TRUE |
21 | YFS | Blood | PFAS | 0.27 | 0.06 | enet | 88 | 0.16 | 2.1e-50 | -6.8 | -5.3 | 1.4e-07 | 0.01 | 0.62 | 0.38 | FALSE |
22 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | CYB5D1 | 0.04 | 0.03 | blup | 40 | 0.02 | 1.6e-02 | 4.6 | -5.6 | 1.9e-08 | -0.11 | 0.03 | 0.05 | FALSE |
23 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ACAP1 | 0.03 | 0.02 | blup | 60 | 0.01 | 1.5e-03 | 3.3 | 6.0 | 2.2e-09 | -0.45 | 0.12 | 0.15 | FALSE |
24 | The Cancer Genome Atlas | Lung Adenocarcinoma | CYB5D1 | 0.05 | 0.03 | blup | 40 | 0.03 | 1.9e-04 | 4.6 | -5.8 | 8.8e-09 | -0.10 | 0.06 | 0.03 | FALSE |
25 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | RANGRF | 0.05 | 0.01 | blup | 46 | 0.02 | 4.0e-03 | -3.4 | -7.0 | 3.3e-12 | 0.03 | 0.01 | 0.88 | FALSE |
26 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PFAS | 0.05 | 0.06 | enet | 6 | 0.03 | 1.5e-04 | -7.3 | -7.2 | 6.4e-13 | 0.07 | 0.01 | 0.99 | TRUE |
27 | The Cancer Genome Atlas | Thyroid Carcinoma | C17orf44 | 0.04 | 0.01 | enet | 9 | 0.01 | 4.0e-02 | -6.3 | 6.2 | 4.5e-10 | -0.05 | 0.02 | 0.55 | FALSE |