Hub : Genes

CYB5D1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.3720	0.0940	0.00015	0.120	NA	0.117	NA	0.123	5.8e-06	NA	7.3e-06	NA	4.2e-06
2	YFS	Blood	0.2802	0.0305	0.00000	0.186	0.224	0.238	0.244	0.231	1.2e-58	1.5e-71	9.3e-77	5.9e-79	3.5e-74
3	TCGA	Bladder Urothelial Carcinoma	0.0410	0.0220	0.00820	0.034	0.016	0.007	NA	0.012	6.3e-04	1.6e-02	7.8e-02	NA	3.1e-02
4	TCGA	Colon Adenocarcinoma	0.1380	0.0520	0.00019	0.116	0.039	0.057	NA	0.102	3.1e-07	2.7e-03	3.3e-04	NA	1.7e-06
5	TCGA	Lung Adenocarcinoma	0.0501	0.0241	0.00130	0.027	0.030	0.019	NA	0.013	3.5e-04	1.9e-04	2.4e-03	NA	8.9e-03
6	TCGA	Prostate Adenocarcinoma	0.0667	0.0340	0.00720	0.019	0.002	0.017	NA	0.005	3.6e-03	1.9e-01	5.5e-03	NA	9.8e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.1	1.7	3.9	1.0	-1.3	-0.8	-1.3	-2.0	-1.2
Bipolar Disorder or Schizophrenia	0.1	0.3	0.6	-0.7	-0.2	0.8	-0.7	-0.2	-0.6
Depressed Affect (Nagel 2018)	0.6	1.2	3.1	-0.4	-0.6	-1.2	-1.8	-1.2	-1.0
Depression (Nagel 2018)	2.3	3.4	9.1	0.4	-1.6	-1.7	-3.0	-1.7	-1.6
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.9	0.3	-0.4	-1.4	-0.0	-0.1	0.6
Neuroticism (Nagel 2018)	0.4	0.9	2.4	-0.9	-0.3	-1.1	-1.5	-1.0	-0.4
Schizophrenia (2018)	0.7	1.4	3.1	-1.7	0.8	1.7	0.1	1.3	0.3
Schizophrenia vs Biploar Disorder	0.9	1.1	2.5	-1.1	0.5	1.6	1.0	1.0	0.8
Worry (Nagel 2018)	0.2	0.5	1.5	-1.2	0.4	-0.6	-0.8	0.1	-0.7
Alzheimer’s Disease (in mother)	0.9	1.0	2.5	0.3	0.6	1.5	0.7	0.7	1.6
Alzheimer’s Disease (in father)	0.6	0.6	1.4	-0.9	0.6	0.0	1.0	-0.5	1.2
Alzheimer’s Disease (including proxy)	0.6	0.9	3.6	0.0	0.4	0.3	0.7	-0.8	1.9
Crohns Disease (2017)	0.3	0.7	1.5	1.2	-0.9	-0.4	-0.5	-1.2	0.4
Irritable Bowel Disease (IBD)	0.2	0.4	1.0	-0.1	-0.3	-0.9	-0.5	-1.0	0.4
Ulcerative Colitis (UC)	0.3	0.6	1.2	-1.1	0.1	-1.1	-0.7	-0.8	-0.2
Major Depression (MDD)	1.6	2.0	4.9	0.5	-1.1	-1.2	-1.3	-2.2	-1.5
Reaction Time	0.8	1.5	2.8	-0.5	1.1	1.4	1.3	1.0	1.7
Verbal and Numeric Reasoning (VNR)	0.2	0.5	2.0	0.6	-0.5	-1.4	-0.3	0.1	-0.5
Breast Cancer	1.0	2.3	4.2	-2.0	1.4	1.7	1.7	1.3	0.7
Ovarian Cancer	0.3	0.4	1.3	0.5	0.5	0.5	1.1	0.1	0.4
Prostate Cancer	1.2	1.7	6.9	0.1	-0.7	-1.5	-0.5	-0.3	-2.6
Age at First Birth	1.7	2.5	3.9	-1.2	2.0	1.8	1.3	1.7	1.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	3.0	4.1	8.0	1.8	-2.8	-2.2	-1.9	-1.8	-1.2
Coronary Artery Disease (CAD)	0.1	0.2	0.8	0.1	0.5	0.0	-0.1	0.0	-0.9
Crohns Disease (2012)	0.6	0.9	1.8	0.8	-0.7	-1.4	-1.3	-1.0	-0.0
Mean Putamen Volume	0.5	0.6	0.8	-0.3	0.8	0.7	0.9	0.9	0.8
Fasting Glucose	0.2	0.2	1.1	-0.0	-1.1	-0.2	0.3	-0.4	-0.3
HbA1C	0.6	0.6	1.6	1.3	-0.7	-0.8	-0.1	-0.9	-0.5
HDL Cholesterol	0.2	0.4	1.2	-0.3	-0.3	-0.6	-0.7	-0.3	-1.1
LDL Cholesterol	0.9	1.5	2.9	1.7	-1.7	-0.6	-0.3	-1.4	-0.8
Lupus	0.5	0.8	2.4	1.5	-1.4	-0.2	-0.1	-0.6	-0.2
Neuroticism (2016)	0.3	0.5	1.4	0.4	-0.5	-0.7	-0.6	-1.2	0.2
Primary Biliary Cirrhosis	2.5	3.6	7.6	0.0	-1.7	-1.9	-2.8	-0.9	-2.5
Rheumatoid Arthritis	1.1	1.5	3.8	1.9	-1.6	-0.3	-0.7	-1.3	-0.7
Schizophrenia (2014)	0.4	0.9	3.5	-1.4	0.3	1.9	0.0	0.5	-0.1
Triglycerides	1.0	1.6	2.5	1.4	-1.5	-0.9	-1.3	-1.6	-0.8
Type 2 Diabetes (T2D) (2012)	1.1	1.3	4.9	-1.3	0.4	0.1	-0.4	0.8	-2.2
Ulcerative Colitis	0.5	0.7	2.1	-0.7	1.1	0.1	0.8	0.4	1.4
Blood Eosinophil Count	0.6	5.0	11.6	3.4	-3.4	0.3	1.6	0.9	-1.8
Blood Platelet Count	0.6	7.5	22.4	0.5	-0.1	-4.7	1.0	-4.6	0.6
Blood Red Count	6.1	59.3	81.7	5.6	-8.7	-9.0	-7.4	-7.9	-7.0
Blood White Count	4.0	29.9	43.7	5.1	-6.6	-5.6	-4.5	-5.8	-5.0
Heel T-Score	13.8	109.7	161.3	-6.8	10.9	12.7	12.7	10.8	7.4
BMI	2.1	12.1	20.1	2.1	-4.1	-4.5	-3.6	-3.7	-2.1
Height	0.3	4.9	9.5	-3.1	2.6	2.4	1.3	2.3	-0.7
Waist Hip Ratio (WHR)	0.7	2.9	5.5	-0.2	2.2	1.5	2.3	0.2	2.3
Systolic Blood Pressure	4.4	21.9	40.3	2.7	-4.8	-4.9	-6.3	-3.7	-4.8
Smoking Status	1.9	4.6	12.2	-2.4	2.0	3.5	0.2	2.2	-0.8
Allergy or Eczema	0.8	2.0	3.8	0.1	0.5	1.4	2.0	1.9	1.7
Cardiovascular Disease	5.5	18.0	34.8	3.1	-4.0	-3.6	-5.9	-3.9	-4.4
Hypothyroidism (self reported)	2.0	4.6	13.0	1.9	-3.6	-1.1	-1.1	-0.6	-2.9
Respiratory disease	0.3	0.6	1.9	-0.1	0.5	1.4	1.0	0.7	0.2
Type 2 Diabetes (T2D) (2018)	1.3	2.3	5.2	2.1	-2.3	-0.4	0.2	-1.9	-0.8
Lung FEV1/FVC ratio	1.4	7.3	20.5	1.2	0.7	2.5	4.5	2.6	2.8
Lung FVC	1.9	9.7	16.6	0.3	-2.4	-3.7	-4.1	-3.5	-3.2
Neuroticism	0.2	0.6	1.5	-0.5	-0.4	-0.3	-1.2	-0.0	-1.2
Chronotype (morning person)	0.7	1.6	5.3	0.7	-0.3	-2.3	-0.3	-1.4	1.3
Hair Pigment	0.1	1.6	2.7	0.1	-0.8	-1.6	-1.6	-1.3	-1.4
Tanning	0.6	7.3	12.2	-3.4	3.5	2.1	2.2	2.7	1.9
Hand grip strength (left)	0.5	1.2	4.4	-2.1	1.1	0.6	0.9	0.7	-0.3
Number of treatments/medications taken	1.3	2.3	4.2	0.9	-1.7	-1.0	-2.0	-1.4	-1.8
Average weekly spirits intake	1.8	2.2	4.6	-2.2	1.9	1.0	0.1	1.5	-1.2
Sensitivity / hurt feelings	2.1	3.6	5.9	1.0	-2.0	-1.6	-2.4	-2.2	-1.8
Frequency of depressed mood in last 2 weeks	2.1	2.9	6.9	0.0	-1.1	-2.1	-2.6	-2.2	-0.1
Hearing difficulty/problems: Yes	0.3	0.5	1.5	-0.6	-0.3	-0.6	-1.2	-0.7	-0.4
Relative age of first facial hair	1.0	2.1	6.7	1.0	-1.0	-1.0	-1.6	-0.4	-2.6
Other serious medical condition/disability diagnosed by doctor	3.6	4.6	10.0	2.8	-3.2	-1.8	-1.1	-1.9	-1.3
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.3	-0.6	-1.0	-1.1	-0.7	-1.5	-0.4
Ever had hysterectomy (womb removed)	0.9	1.0	2.3	0.8	-1.2	-0.4	-1.2	-1.5	-0.5
Systolic blood pressure, automated reading	2.3	6.7	14.0	1.5	-2.8	-2.5	-3.7	-2.2	-2.3
Eye problems/disorders: Diabetes related eye disease	3.2	3.5	5.2	-1.5	2.3	2.2	2.1	1.6	1.1
Angina	0.0	0.0	0.2	-0.0	-0.4	0.2	-0.0	0.3	-0.1
Medication for hormone replacement therapy	1.1	1.2	4.4	-2.1	1.0	0.7	-0.2	1.0	0.4
Vitamin and mineral supplements	0.6	0.8	3.3	0.4	0.6	0.5	0.7	0.2	1.8
Supplements: Zinc	0.8	0.9	1.9	-0.5	1.1	1.4	0.6	1.1	-0.5
Medication: Co-codamol	4.2	4.9	7.8	2.0	-2.7	-2.3	-1.8	-2.8	-1.3
Medication: Metformin	2.2	3.0	6.2	1.4	-2.5	-1.3	-0.9	-2.0	-1.8
Diabetes (father)	0.7	0.9	1.8	1.3	-1.2	0.3	0.3	-1.0	-0.9
Diabetes (mother)	0.9	1.1	2.9	0.1	-1.4	-1.7	-0.9	-0.9	-0.2
Severe depression (siblings)	0.4	0.5	1.7	-1.3	1.0	0.0	0.5	0.3	0.1
Pack years adult smoking proportion	1.8	2.8	5.2	1.5	-1.6	-1.7	-2.3	-1.7	-0.8
Impedance of leg (right)	0.0	0.1	0.3	0.6	0.3	0.4	0.0	0.2	0.3
Leg fat-free mass (left)	0.2	0.9	1.8	-1.4	-0.2	-0.8	-1.0	-0.4	-1.3
Trunk fat percentage	0.6	2.5	6.1	0.3	-1.8	-1.4	-2.5	-1.6	-1.1
Hand grip strength (right)	0.6	1.5	4.5	-2.1	1.5	0.9	1.2	0.2	0.4
Townsend deprivation index at recruitment	2.0	2.7	3.6	1.6	-1.9	-1.6	-1.8	-1.7	-1.4
Current tobacco smoking	0.7	1.2	4.2	-0.5	0.9	2.0	0.1	1.1	-0.7
Average weekly fortified wine intake	2.2	2.6	4.0	-2.0	2.0	1.6	1.5	1.6	-0.2
Maternal smoking around birth	1.2	1.8	6.7	-0.4	0.8	2.6	0.8	1.5	-0.5
Fed-up feelings	0.5	0.9	2.1	-0.3	-0.6	-1.4	-1.4	-0.4	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	2.9	1.4	-1.7	-1.7	-1.7	-1.2	0.3
Relative age voice broke	1.2	1.8	6.5	1.0	-0.8	0.8	-0.4	1.5	-2.5
Taking other prescription medications	4.4	6.8	13.0	2.5	-3.6	-2.9	-2.1	-2.6	-1.5
Age when periods started (menarche)	2.6	6.2	8.8	1.5	-2.7	-3.0	-2.7	-2.4	-2.4
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.3	-0.4	-0.3	-0.2	-0.9	-1.2	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	9.9	22.4	29.0	-4.4	5.4	4.4	5.1	4.8	4.3
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.0	-0.2	0.2	0.0	-0.0	-0.2	0.0
Qualifications: CSEs or equivalent	0.5	0.7	3.2	0.2	-0.2	-0.5	-0.8	0.3	-1.8
Serious illness, injury or assault to yourself	0.5	0.6	2.0	-0.4	-0.2	-1.4	-0.5	-0.7	-0.8
High blood pressure	8.9	24.9	47.1	3.7	-5.3	-4.1	-6.9	-5.0	-4.4
Hayfever, allergic rhinitis or eczema	0.9	2.0	4.4	1.1	-0.3	0.9	2.1	1.2	2.0
Multivitamins +/- minerals	0.2	0.2	1.0	-0.2	-0.3	-0.2	-0.5	0.1	-1.0
Stomach or abdominal pain in last month	0.1	0.1	0.5	0.2	0.0	0.3	-0.7	-0.3	-0.4
Supplements: Glucosamine	0.7	0.9	2.9	-1.7	1.1	-0.6	-0.7	-0.7	0.1
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	2.4	1.2	-1.6	0.6	-0.4	-0.2	-1.2
Medication: Atenolol	1.4	1.8	3.3	1.1	-1.5	-1.0	-1.8	-1.2	-1.1
Medication: Levothyroxine sodium	1.9	3.1	6.8	1.1	-2.6	-1.7	-1.0	-1.7	-2.0
Sitting height	0.1	0.9	2.6	-1.6	0.8	0.5	-0.2	1.0	-0.9
Chronic bronchitis/emphysema (father)	0.6	0.7	3.0	-0.6	0.6	0.7	-0.2	1.7	0.4
High blood pressure (mother)	3.5	4.9	6.2	2.0	-2.3	-2.5	-2.4	-1.9	-2.0
Body mass index (BMI)	1.4	5.9	9.5	1.2	-3.1	-2.7	-2.6	-2.8	-1.5
Impedance of leg (left)	0.1	0.4	1.4	1.2	-0.5	-0.1	-0.6	-0.2	-0.5
Leg predicted mass (left)	0.2	0.8	1.8	-1.4	-0.2	-0.7	-1.0	-0.3	-1.2
Trunk fat mass	0.5	2.4	5.3	-0.0	-1.6	-1.5	-2.3	-1.6	-1.2
Waist circumference	0.6	2.1	4.6	0.5	-1.7	-1.5	-1.5	-2.2	-0.8
Number of incorrect matches in round	0.3	0.5	1.2	0.6	-0.7	0.3	-0.8	-1.1	-0.4
Past tobacco smoking	0.5	0.8	3.0	1.7	-0.6	-0.9	0.6	-0.8	0.0
Alcohol usually taken with meals	2.4	3.9	5.3	-2.2	2.3	2.2	2.1	1.9	0.8
Nervous feelings	0.7	1.4	3.1	-0.0	-1.3	-1.8	-1.1	-1.5	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	2.2	0.9	-1.2	-1.2	-1.5	-1.2	-0.3
Hearing difficulty/problems with background noise	0.4	0.7	2.8	-0.0	0.5	1.0	0.2	0.3	1.7
Hair/balding pattern: Pattern 2	0.9	1.1	2.6	-0.5	1.0	0.8	0.8	1.6	-1.2
Had menopause	0.4	0.4	1.0	-0.9	0.3	0.0	0.5	-0.7	1.0
Had other major operations	1.1	1.4	3.8	-0.0	-1.9	-0.6	-1.5	-0.9	-1.0
Forced vital capacity (FVC)	0.5	2.0	4.3	-1.1	0.0	-1.5	-1.8	-1.0	-2.1
Heel bone mineral density (BMD) T-score, automated (right)	8.2	18.8	24.8	-3.6	5.0	4.3	4.7	4.4	3.9
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.7	0.0	0.8	-0.5	-0.3	-0.4	0.5
Qualifications: None of the above	2.8	6.0	8.9	2.6	-2.6	-2.1	-2.6	-3.0	-1.5
Financial difficulties in last 2 years	0.6	0.9	2.5	0.6	-0.8	-0.8	-1.6	-0.9	-0.5
Mouth/teeth dental problems	1.9	2.9	8.0	1.4	-1.8	-1.0	-1.8	-2.8	-0.3
Heart attack	0.2	0.3	1.4	0.2	-0.4	-0.2	-1.2	-0.1	-0.3
Allergy	0.8	1.8	5.4	-2.3	1.8	-0.1	-0.9	0.2	-1.2
Pain all over the body in last month	4.1	4.4	8.4	1.6	-2.5	-2.1	-1.6	-2.9	-1.3
Diabetes (self-reported)	1.5	2.4	5.6	1.9	-2.4	-0.5	-0.4	-1.7	-1.4
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	5.3	-0.0	0.9	1.0	2.3	1.0	0.7
Medication: Ramipril	2.6	3.3	4.9	1.4	-1.6	-1.6	-2.2	-2.2	-1.6
Medication: Simvastatin	0.5	0.7	2.4	1.5	-1.0	0.3	-0.5	0.1	-0.8
Fluid intelligence score	0.2	0.4	1.2	0.7	-0.6	-1.1	0.1	0.6	0.3
Illnesses of siblings	2.5	3.6	7.0	-2.3	2.6	1.8	1.1	2.2	0.1
Neuroticism score	0.5	1.1	2.5	-0.1	-1.1	-1.3	-1.6	-0.7	-0.9
Weight	0.6	2.8	4.9	-0.3	-1.7	-1.8	-2.2	-1.7	-1.7
Impedance of arm (right)	2.1	9.8	16.6	-2.3	3.8	4.1	2.4	3.2	2.7
Arm fat percentage (right)	0.2	0.9	2.0	0.0	-1.2	-0.7	-1.4	-1.1	-0.0
Trunk fat-free mass	0.1	0.6	1.8	-1.4	-0.1	-0.6	-0.5	-0.2	-1.1
Hip circumference	1.0	4.1	8.5	-0.2	-2.0	-2.1	-2.9	-1.6	-2.3
Time employed in main current job	0.7	0.8	2.6	-1.6	1.4	-0.4	0.0	0.3	-0.4
Alcohol intake versus 10 years previously	0.6	0.9	3.1	1.0	-0.1	-1.0	-0.5	-1.8	0.5
Father’s age at death	0.3	0.4	1.3	-0.4	0.2	0.5	0.7	1.2	-0.2
Worrier / anxious feelings	0.4	0.8	3.0	-1.7	1.3	-0.0	-0.2	0.2	0.3
Frequency of tiredness / lethargy in last 2 weeks	3.9	6.3	10.7	1.0	-2.4	-2.9	-3.3	-2.6	-2.2
Falls in the last year	0.7	1.0	2.4	-0.2	1.0	1.6	0.9	1.2	-0.2
Hair/balding pattern: Pattern 3	3.5	5.2	8.9	2.8	-3.0	-1.7	-2.0	-2.4	-1.5
Number of live births	5.5	7.8	14.2	3.6	-3.8	-2.5	-2.2	-2.8	-0.7
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	2.3	-0.2	-0.6	-1.5	-1.2	-1.1	-1.5
Pulse rate	0.5	0.9	3.3	-0.8	-0.0	0.0	-1.3	0.2	-1.8
Happiness	0.7	0.9	1.5	-0.2	-1.0	-1.1	-1.2	-0.7	-1.0
Noisy workplace	1.1	1.3	2.5	0.8	-1.1	-1.6	-1.0	-1.2	-0.9
Qualifications: A levels/AS levels or equivalent	1.8	4.0	7.7	-2.0	2.4	1.7	1.8	2.8	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	3.1	-1.3	0.0	-0.2	-0.2	1.1	-1.8
Mouth/teeth dental problems: Dentures	0.1	0.1	0.6	0.1	0.4	-0.3	-0.1	0.8	-0.0
Asthma	0.7	1.4	3.1	1.2	-0.3	1.3	1.8	0.5	1.3
Medication: Ibuprofen (e.g. Nurofen)	3.5	4.4	6.5	-2.0	2.3	2.4	1.7	2.5	1.4
Medication: Cholesterol lowering	0.3	0.4	1.4	1.2	0.1	1.0	0.2	0.4	-0.3
Depression (self-reported)	1.5	1.8	3.8	1.8	-1.6	-0.8	-0.6	-2.0	0.3
Medication: Lansoprazole	0.5	0.6	1.1	0.4	0.1	1.0	0.9	1.1	0.6
Prospective memory result	0.8	1.0	1.9	1.2	-1.4	-1.1	-0.7	-1.1	0.1
Lung cancer (father)	1.2	1.4	4.0	0.0	-0.7	-2.0	-1.1	-1.6	0.3
Illnesses of mother	0.5	0.6	1.5	-0.6	0.5	0.4	1.2	1.1	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	2.7	-0.5	-0.4	-0.9	-1.0	-0.2	-1.6
Pulse wave Arterial Stiffness index	0.3	0.3	0.9	0.7	-0.1	-0.2	1.0	0.5	0.6
Impedance of arm (left)	1.2	5.7	10.5	-1.7	3.0	3.2	1.5	2.5	1.7
Arm fat mass (right)	0.4	1.7	3.1	-0.0	-1.6	-1.3	-1.8	-1.5	-0.7
Trunk predicted mass	0.1	0.6	1.8	-1.4	-0.1	-0.6	-0.4	-0.2	-1.0
Standing height	0.4	4.1	10.4	-3.2	2.8	1.5	0.6	2.0	-0.4
Length of working week for main job	0.6	0.7	2.4	-0.6	0.7	-0.5	-0.4	-0.5	1.6
Exposure to tobacco smoke at home	0.5	0.6	1.3	0.4	-0.7	-0.2	-0.9	-1.2	-0.9
Breastfed as a baby	1.3	1.6	3.0	-1.0	1.7	1.1	1.3	1.6	0.5
Tense / ‘highly strung’	1.4	2.4	3.6	1.8	-1.9	-1.9	-1.1	-1.6	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	2.3	3.5	6.5	-0.5	-1.9	-2.0	-2.5	-1.5	-2.0
Hair/balding pattern: Pattern 4	0.4	1.1	3.1	-1.1	0.9	-0.7	0.6	-0.5	1.8
Birth weight of first child	0.7	1.3	2.9	-0.3	-0.7	-1.7	-1.2	-1.3	-1.0
Peak expiratory flow (PEF)	0.0	0.0	0.1	0.3	-0.3	-0.3	-0.2	-0.1	0.1
Pulse wave reflection index	0.6	0.7	3.1	1.8	-0.9	-0.7	-0.1	0.2	0.2
Ever highly irritable/argumentative for 2 days	0.7	0.9	1.6	-0.8	0.7	0.8	1.3	1.2	0.8
Loud music exposure frequency	1.0	1.0	2.5	-1.2	0.2	-0.6	-1.3	0.6	-1.6
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	3.1	-0.8	1.3	0.7	1.3	1.7	-0.7
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	3.7	-0.3	1.1	-0.0	1.6	1.9	0.7
Blood clot in the leg (DVT)	9.2	11.9	20.1	3.1	-4.5	-3.4	-3.4	-3.7	-2.2
Medication: Paracetamol	0.4	0.7	1.4	-0.5	-0.4	-0.9	-1.2	-1.2	-0.4
Headache pain in last month	1.2	2.1	3.3	-1.0	1.8	1.6	1.4	1.5	1.2
Medication for cholesterol, blood pressure or diabetes	2.5	4.2	9.9	-1.0	1.5	1.3	3.1	1.8	2.6
Glaucoma (self-reported)	1.6	1.9	2.9	1.1	-1.7	-1.4	-1.2	-1.3	-1.5
Gout (self-reported)	4.3	5.9	15.1	1.0	-2.3	-2.0	-3.1	-0.6	-3.9
Hypothyroidism/myxoedema (self-reported)	1.6	3.1	8.3	1.8	-2.9	-1.0	-0.6	-0.3	-2.4
Medication: Amlodipine	6.5	9.1	14.2	2.7	-3.4	-2.6	-3.8	-2.2	-3.2
Medication: Ventolin 100micrograms inhaler	0.5	0.6	2.1	0.7	-0.0	0.5	1.4	1.0	0.2
Birth weight	0.5	1.0	4.7	-0.3	-0.0	0.2	-0.3	1.0	-2.2
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.5	-0.2	-0.1	0.7	-0.0	-0.3	0.5
High blood pressure (siblings)	2.0	2.9	4.8	2.1	-2.2	-2.1	-1.2	-1.5	0.2
Forced vital capacity (FVC), Best measure	0.4	1.4	3.3	-1.3	0.3	-1.0	-1.5	-0.5	-1.8
Body fat percentage	0.9	3.7	6.5	0.8	-2.3	-1.8	-2.5	-2.1	-1.3
Leg fat percentage (right)	1.9	6.9	10.7	1.7	-3.2	-2.9	-2.9	-3.3	-1.1
Arm fat-free mass (right)	0.8	4.2	7.5	0.0	-2.0	-2.5	-2.1	-1.8	-2.7
Exposure to tobacco smoke outside home	0.3	0.4	1.1	-0.5	1.0	0.7	0.6	0.2	0.5
Comparative body size at age 10	0.6	1.7	4.5	-1.6	1.1	0.7	1.2	2.1	-0.0
Number of full brothers	0.8	1.0	3.5	1.1	-1.9	-0.8	-0.5	0.0	-0.4
Worry too long after embarrassment	0.2	0.3	0.8	-0.9	0.3	-0.2	0.1	0.8	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.3	1.1	-1.1	-0.8	-1.1	-1.0	-0.3
Wheeze or whistling in the chest in last year	0.5	0.9	2.2	0.4	-1.3	0.0	-1.0	-0.8	-1.5
Number of children fathered	2.0	2.3	5.6	-0.4	1.2	2.4	1.9	1.6	0.6
Reason for reducing amount of alcohol drunk: Health precaution	2.6	3.0	6.5	2.5	-1.9	-1.0	-1.6	-2.0	0.8
Age at first live birth	0.7	1.3	3.5	-1.9	1.3	1.2	-0.6	0.9	0.3
Pulse wave peak to peak time	0.3	0.4	0.9	-0.8	0.3	0.3	-0.9	-0.4	-0.7
Health satisfaction	0.5	0.7	2.0	-0.2	0.6	1.2	0.1	1.4	-0.4
Shortness of breath walking on level ground	0.2	0.3	0.6	0.2	0.1	0.7	-0.6	0.4	-0.7
Qualifications: College or University degree	0.5	1.5	3.7	-1.0	0.9	1.2	1.1	1.9	1.0
Eye problems/disorders: None of the above	0.2	0.2	0.8	0.9	-0.3	-0.3	0.3	0.3	-0.3
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.4	-1.6	1.2	1.1	0.5	1.3	-0.3
Emphysema/chronic bronchitis	1.4	1.6	3.3	-1.8	0.1	-0.2	-1.6	0.4	-1.8
Medication for pain relief, constipation, heartburn	0.4	0.7	2.4	0.6	0.1	-0.3	1.5	0.1	1.1
Neck or shoulder pain in last month	1.2	1.7	3.8	1.2	-1.5	-1.3	-1.9	-0.8	-0.6
Medication: Blood pressure	5.1	9.0	23.7	1.3	-2.3	-2.4	-4.9	-2.6	-3.3
Angina (self-reported)	0.1	0.1	0.3	0.1	-0.6	-0.1	-0.2	-0.1	0.0
Migraine (self-reported)	0.7	0.8	2.0	-0.9	1.4	0.8	0.7	0.5	1.0
Medication: Ibuprofen	3.6	4.3	6.8	-2.0	2.3	2.1	1.8	2.6	1.6
Medication: Allopurinol	10.1	13.5	19.5	2.3	-4.2	-3.8	-4.4	-2.4	-4.3
Medication: Omeprazole	0.7	0.8	2.2	1.1	-0.9	-0.5	-0.3	-1.5	0.4
Medication: Seretide 50 evohaler	0.1	0.1	0.4	-0.6	0.3	-0.1	0.1	-0.1	-0.4
Mean time to correctly identify matches	1.1	2.0	4.4	-0.8	1.4	1.4	1.6	0.8	2.1
Heart disease (mother)	1.5	1.8	4.3	0.4	-0.9	-1.5	-2.1	-1.8	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	1.4	-0.1	0.5	-0.0	0.8	0.4	1.2
Whole body fat mass	0.7	2.8	5.2	0.2	-1.9	-1.6	-2.3	-1.8	-1.5
Leg fat mass (right)	1.4	5.6	8.0	1.1	-2.8	-2.6	-2.8	-2.7	-1.7
Arm predicted mass (right)	0.8	4.1	6.4	-0.1	-1.9	-2.5	-2.1	-1.9	-2.5
Pulse rate, automated reading	1.2	3.9	5.4	1.3	-1.9	-2.0	-2.3	-1.9	-2.3
Alcohol intake frequency.	1.8	4.2	9.5	3.1	-2.2	-2.4	-0.3	-1.9	-1.2
Comparative height size at age 10	1.2	6.4	11.0	-3.3	2.9	2.6	1.6	2.9	1.2
Number of full sisters	0.6	0.7	1.9	0.1	-0.7	-0.5	-1.3	-1.4	-0.4
Suffer from ‘nerves’	0.8	1.3	2.9	0.3	-1.0	-1.7	-1.4	-1.2	-0.6
Overall health rating	1.7	3.7	5.1	1.3	-2.2	-2.0	-2.0	-2.3	-1.4
Chest pain or discomfort	0.9	1.2	3.2	-0.2	-1.1	-1.5	-0.7	-1.8	0.3
Had major operations	2.0	2.3	4.0	-0.0	-1.1	-1.7	-2.0	-1.7	-1.8
Age at last live birth	0.3	0.5	1.5	-1.2	0.4	0.9	-0.5	0.2	0.0
Family relationship satisfaction	0.3	0.3	1.3	-0.7	-0.1	-0.2	-1.1	-0.2	-0.1
Leg pain on walking	0.9	1.1	2.0	1.3	-1.1	-0.9	-0.5	-1.4	0.7
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	3.2	0.1	-1.0	-1.4	-0.8	-1.8	-0.9
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.7	-0.7	0.1	-0.4	-0.8	-0.2	-0.6
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.8	0.5	0.0	0.9	0.4	0.7	-0.3
Medication: Aspirin	3.1	4.1	8.6	1.1	-2.4	-1.4	-2.9	-1.7	-2.1
Supplements: Vitamin C	0.3	0.3	0.7	0.2	-0.2	-0.0	-0.6	-0.9	-0.8
Knee pain experienced in last month	0.1	0.1	0.4	-0.4	0.2	0.2	-0.3	0.2	0.6
Hypertension (Self-reported)	9.5	26.4	51.7	3.6	-5.4	-4.3	-7.2	-4.9	-4.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.4	0.8	-1.2	-0.2	-0.2	0.2	-1.6
Illnesses of father: Heart disease	0.8	1.1	2.5	-0.8	1.4	1.1	0.8	1.6	-0.0
Illnesses of siblings: Diabetes	0.5	0.6	2.3	0.2	-0.7	-0.6	-0.4	-0.6	-1.5
Smoking status: Previous	0.5	0.7	3.4	-1.8	0.7	0.2	-0.5	0.4	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.9	0.1	-0.3	-0.1	-0.7	0.6	-1.0
Whole body fat-free mass	0.1	0.7	1.6	-1.2	-0.2	-0.7	-0.6	-0.3	-1.2
Leg fat-free mass (right)	0.2	0.8	1.9	-1.2	-0.3	-0.7	-1.0	-0.2	-1.4
Arm fat percentage (left)	0.5	2.0	4.1	0.4	-1.8	-1.2	-2.0	-1.6	-0.7
Average weekly red wine intake	1.2	1.7	3.8	-1.9	1.1	2.0	0.7	1.0	-0.6
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.5	0.8	-0.7	-0.8	-1.0	-1.6	-0.8
Mood swings	0.2	0.3	0.8	-0.9	0.2	-0.0	-0.7	0.7	-0.3
Loneliness, isolation	0.1	0.1	0.3	-0.1	-0.4	-0.1	-0.6	-0.4	-0.4
Long-standing illness, disability or infirmity	2.3	3.6	5.2	0.2	-1.9	-2.2	-1.9	-2.3	-2.1
Ever had bowel cancer screening	0.7	0.8	1.6	-0.6	-0.7	-1.0	-0.6	-1.3	0.9
Diabetes diagnosed by doctor	1.1	1.8	4.3	1.8	-2.1	-0.3	-0.1	-1.5	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.8	0.1	0.2	0.9	-0.0	0.3	0.7
Friendships satisfaction	0.7	0.9	2.9	-1.7	0.8	-1.0	-0.9	-0.3	0.3
Qualifications: nursing, teaching	1.7	2.6	5.9	-2.4	1.9	0.7	1.3	2.0	-0.0
Commuting to job workplace: Walk	0.2	0.2	0.7	0.1	0.7	-0.8	0.2	-0.2	-0.4
Eye problems/disorders: Cataract	0.6	0.7	1.5	0.1	-0.9	-0.5	-1.0	-1.2	0.7
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	4.0	-1.8	2.0	1.0	1.4	1.6	0.6
Medication for cholesterol	3.2	4.9	8.9	-1.5	3.0	2.3	2.6	2.1	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	-0.1	0.5	0.2	-0.1	0.1	-0.4
Back pain experienced in last month	0.1	0.2	0.5	-0.1	-0.5	0.1	-0.3	0.4	0.7
Mineral and other dietary supplements	0.3	0.4	0.7	0.8	-0.6	0.5	0.6	0.0	0.8
Breast cancer (self-reported)	0.1	0.1	0.6	0.4	-0.2	0.0	0.0	0.2	-0.8
Asthma (self-reported)	0.7	1.4	3.3	1.5	-0.5	1.1	1.8	0.2	1.2
Osteoporosis (self-reported)	0.9	1.2	2.4	0.6	-1.5	-0.8	-1.2	-0.8	-1.3
Osteoarthritis (self-reported)	2.2	2.9	6.0	1.3	-1.6	-1.5	-2.5	-1.8	-1.2
Medication: Aspirin	4.0	5.2	11.1	1.2	-2.4	-1.5	-3.3	-2.3	-2.3
Medication: Gliclazide	2.2	2.4	4.4	0.8	-1.6	-0.8	-1.8	-1.8	-2.1
Illnesses of father: None of the above (group 1)	0.3	0.4	1.4	-0.4	-0.3	-1.2	-0.5	-0.7	-0.1
Smoking status: Current	0.6	1.0	3.6	-0.4	0.7	1.9	0.1	1.0	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.4	5.1	7.1	1.9	-2.6	-2.7	-2.1	-1.9	-2.4
Whole body water mass	0.1	0.8	1.7	-1.2	-0.3	-0.8	-0.8	-0.4	-1.3
Leg predicted mass (right)	0.2	0.9	2.0	-1.2	-0.3	-0.8	-1.1	-0.3	-1.4
Arm fat mass (left)	0.5	2.2	4.0	0.1	-1.8	-1.5	-2.0	-1.5	-1.2
Number of self-reported non-cancer illnesses	9.1	15.7	21.8	3.8	-4.7	-3.2	-4.2	-3.7	-4.0
Average weekly champagne plus white wine intake	2.6	3.6	5.5	-2.1	1.8	1.5	1.7	2.3	1.8
Miserableness	3.8	6.5	8.5	1.6	-2.9	-2.9	-2.9	-2.8	-2.0
Guilty feelings	0.9	1.4	3.5	-0.2	-1.3	-1.2	-1.9	-1.1	-0.7
Wears glasses or contact lenses	2.3	2.7	4.0	-1.1	1.8	1.0	1.8	1.9	2.0
Ever taken oral contraceptive pill	2.9	3.3	5.1	-0.9	2.1	1.7	1.6	2.0	2.3
Hearing aid user	0.4	0.5	1.2	-0.6	0.7	0.5	-0.4	0.6	-1.1
Mother’s age at death	4.6	5.7	7.9	-2.1	2.7	2.1	2.7	2.8	1.7
Financial situation satisfaction	3.2	4.0	6.0	1.0	-2.3	-1.9	-2.5	-1.5	-2.4
Tinnitus: Yes, now most or all of the time	1.4	1.6	3.5	-1.9	1.6	0.7	1.0	0.3	1.5
Commuting to job workplace: Public transport	0.4	0.4	0.9	0.4	0.3	0.9	1.0	0.5	0.6
Eye problems/disorders: Glaucoma	1.7	2.1	3.2	1.4	-1.8	-1.4	-1.1	-1.3	-1.4
Medication: Blood pressure	9.4	18.0	29.5	4.3	-5.4	-3.7	-4.6	-3.9	-3.2
Pain type(s) experienced in last month: Hip pain	0.3	0.3	1.1	-0.1	0.4	0.2	0.1	-0.8	1.1
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.4	-0.6	0.5	-0.5	-0.5	-0.1	-0.1
High cholesterol (Self-reported)	0.4	0.7	2.5	1.6	-0.5	0.6	0.1	0.8	-0.8
Medication: Bendroflumethiazide	4.5	6.8	10.3	2.2	-2.6	-3.2	-3.2	-2.4	-1.7
Medication: Paracetamol	0.7	1.2	2.5	-0.0	-0.8	-1.4	-1.6	-1.2	-0.6
Medication: Lisinopril	2.8	3.6	8.4	0.7	-1.9	-0.8	-2.4	-1.7	-2.9
Medication: Atorvastatin	0.9	1.1	2.7	1.6	-1.3	-0.5	-0.1	-1.4	-0.6
Illnesses of father: High blood pressure	3.2	3.9	5.7	2.0	-2.4	-1.5	-2.0	-2.1	-1.8
Alcohol drinker status: Never	1.6	1.9	6.1	2.5	-1.5	-0.9	-0.1	-1.4	-0.3
Ever smoked	1.8	3.2	6.5	-2.6	1.9	2.2	0.3	2.1	0.0
Basal metabolic rate	0.2	1.2	2.3	-1.0	-0.7	-1.2	-1.3	-0.8	-1.5
Leg fat percentage (left)	2.2	7.9	11.8	1.8	-3.4	-3.1	-3.1	-3.4	-1.5
Arm fat-free mass (left)	0.4	2.2	3.3	-0.3	-1.5	-1.8	-1.5	-1.5	-1.7
Number of operations (self-reported)	0.5	0.8	2.3	-0.7	-0.4	-0.3	-1.1	-1.5	-0.8
Average weekly beer plus cider intake	1.1	1.6	2.4	1.2	-1.3	-1.4	-1.3	-1.6	-0.6
Irritability	0.7	1.1	2.9	0.3	0.3	1.7	1.0	1.5	0.7
Risk taking	0.2	0.4	0.9	0.7	-0.6	0.9	0.5	0.3	0.2
Ever had prostate specific antigen (PSA) test	1.2	1.4	5.6	-0.6	-0.1	0.2	-1.5	0.4	-2.4
Fractured/broken bones in last 5 years	0.4	0.6	1.9	-0.4	-0.8	-0.6	-0.5	-0.2	-1.4
Age started oral contraceptive pill	0.5	0.7	1.4	-0.6	-0.4	-1.2	0.6	-0.8	1.0
Diastolic blood pressure, automated reading	6.4	20.0	39.3	2.2	-4.0	-4.3	-6.3	-4.9	-4.2
Ever depressed for a whole week	1.1	1.4	3.1	-1.2	1.4	1.2	0.7	1.8	0.0
Unable to work because of sickness or disability	0.9	1.1	2.2	0.5	-1.3	-1.0	-1.5	-0.7	-1.1
Commuting to job workplace: Cycle	1.0	1.2	3.8	1.2	-0.1	1.2	2.0	0.4	0.5
Myopia	0.7	1.0	2.7	-0.9	0.2	-0.5	0.6	1.6	1.3
Vascular/heart problems diagnosed by doctor	6.2	16.8	34.9	-2.9	4.2	3.3	5.9	4.1	3.4
Cholesterol lowering medication	1.7	2.6	6.4	2.1	-2.5	-1.0	-0.8	-1.1	-1.3
Medication: Omeprazole (e.g. Zanprol)	1.5	1.8	4.4	1.9	-1.3	-0.9	-0.6	-2.1	0.1
Pain experienced in last month	0.2	0.3	1.3	1.1	-0.4	-0.4	0.4	-0.4	-0.2
Supplements: Calcium	0.4	0.5	1.3	-0.0	-0.1	0.8	1.2	1.0	-0.2
Basal cell carcinoma (self-reported)	0.7	0.9	1.5	-0.8	1.2	0.9	0.4	1.2	0.9
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.8	0.2	-0.3	0.1	-0.9	0.0	-0.1
Deep venous thrombosis (DVT) (self-reported)	9.6	12.3	20.6	3.1	-4.5	-3.3	-3.6	-3.6	-2.5
Heart disease (siblings)	1.5	1.9	5.6	2.0	-2.4	-0.2	-0.7	-1.1	-0.1
Alcohol drinker status: Previous	1.2	1.3	3.4	-0.1	-0.6	-1.9	-1.1	-1.5	-0.8
Pack years of smoking	1.1	1.6	3.7	1.0	-1.0	-1.4	-1.9	-1.3	-0.3
Impedance of whole body	0.4	2.0	4.2	-0.4	1.6	2.1	0.9	1.7	1.0
Leg fat mass (left)	1.7	6.6	9.6	1.3	-3.1	-2.7	-3.1	-2.9	-1.9
Arm predicted mass (left)	0.4	2.1	3.2	-0.3	-1.6	-1.8	-1.4	-1.4	-1.8