TWAS hub - LSMD1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.2060	0.0540	5.6e-05	0.104	NA	0.132	NA	0.126	8.3e-09	NA	6.5e-11	NA	1.8e-10
2	GTEx	Colon Transverse	0.2790	0.0750	9.3e-04	0.120	NA	0.167	NA	0.186	2.5e-06	NA	2.4e-08	NA	3.3e-09
3	YFS	Blood	0.0846	0.0189	2.8e-11	0.016	0.031	0.036	0.035	0.032	4.7e-06	2e-10	5.8e-12	1.4e-11	1.1e-10

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Heel T-Score	15.2	120.8	146.4	-11.0	-12.1	-9.8
Heel bone mineral density (BMD) T-score, automated (left)	7.6	17.3	32.3	-3.8	-5.7	-2.3
Diastolic blood pressure, automated reading	7.1	21.9	31.9	4.6	5.6	3.5
Hypertension (Self-reported)	6.8	18.9	45.3	3.1	6.7	1.3
Heel bone mineral density (BMD) T-score, automated (right)	6.7	15.4	25.2	-3.7	-5.0	-2.8
High blood pressure	6.3	17.6	42.6	3.0	6.5	1.1
Medication: Blood pressure	5.6	10.7	29.4	1.2	5.4	1.1
Number of self-reported non-cancer illnesses	5.0	8.7	22.0	1.9	4.7	0.5
Medication: Allopurinol	4.9	6.6	16.6	1.6	4.1	0.5
Vascular/heart problems diagnosed by doctor	4.7	12.8	30.1	-2.7	-5.5	-1.1
Deep venous thrombosis (DVT) (self-reported)	4.5	5.8	14.4	1.8	3.8	0.0
Primary Biliary Cirrhosis	4.3	6.1	11.4	3.4	2.0	1.7
Blood clot in the leg (DVT)	4.2	5.4	13.5	1.7	3.7	0.1
Medication: Amlodipine	4.1	5.7	14.4	1.3	3.8	-1.0
Cardiovascular Disease	4.0	13.1	34.1	1.8	5.8	1.4
Number of live births	3.7	5.3	11.0	1.9	3.3	1.1
Mother’s age at death	3.7	4.6	8.6	-2.3	-2.9	0.0
Medication: Blood pressure	3.6	6.3	14.3	2.0	3.8	0.8
Medication: Aspirin	3.6	4.6	8.0	2.3	2.8	0.8
Blood Red Count	3.4	32.8	66.3	5.7	8.1	-0.6
Systolic Blood Pressure	3.4	17.1	37.0	3.7	6.1	0.7
Length of working week for main job	3.3	3.7	7.8	1.8	0.0	2.8
Medication: Lisinopril	3.2	4.1	4.7	2.2	2.0	1.8
Basal cell carcinoma (self-reported)	3.1	3.7	6.1	-2.5	-0.5	-2.2
Lung FEV1/FVC ratio	2.8	14.4	31.0	-5.6	-2.8	-2.0
Medication: Co-codamol	2.8	3.2	4.9	1.6	2.2	1.5
Medication: Bendroflumethiazide	2.8	4.3	11.6	1.0	3.4	0.6
Eye problems/disorders: Diabetes related eye disease	2.7	2.9	4.3	-2.0	-2.1	0.6
Breastfed as a baby	2.6	3.2	6.7	-1.0	-1.4	-2.6
Financial situation satisfaction	2.6	3.2	4.5	1.6	2.1	1.6
Blood White Count	2.5	18.2	32.3	2.0	5.7	4.3
Bilateral oophorectomy (both ovaries removed)	2.5	2.9	5.2	1.8	0.5	2.3
Mouth/teeth dental problems	2.5	3.8	7.0	2.6	2.1	0.3
Hair/balding pattern: Pattern 3	2.5	3.7	7.6	0.6	2.8	1.8
Medication: Aspirin	2.5	3.3	6.2	1.8	2.5	0.9
Neck or shoulder pain in last month	2.4	3.4	4.0	1.5	2.0	2.0
Heart disease (mother)	2.4	2.9	5.2	2.3	1.8	0.3
Mouth/teeth dental problems: Mouth ulcers	2.4	3.8	6.1	-2.5	-1.9	-1.2
High blood pressure (mother)	2.3	3.2	7.6	1.4	2.8	0.2
Qualifications: None of the above	2.2	4.6	9.0	1.9	3.0	1.1
Reason for reducing amount of alcohol drunk: Health precaution	2.2	2.6	5.0	1.6	2.2	0.3
Miserableness	2.2	3.9	8.0	0.2	2.8	1.9
Pack years adult smoking proportion	2.1	3.3	6.6	1.2	2.6	1.4
Frequency of tiredness / lethargy in last 2 weeks	2.1	3.4	7.6	1.4	2.8	0.7
Illness, injury, bereavement, stress in last 2 years	2.1	2.6	7.5	0.5	-0.1	-2.7
Systolic blood pressure, automated reading	2.0	5.8	12.6	2.1	3.5	-0.5
Medication: Ibuprofen	2.0	2.4	4.2	-1.7	-2.0	0.3
Pulse rate, automated reading	2.0	6.4	10.8	1.8	2.2	3.3
Leg pain on walking	2.0	2.4	6.0	0.6	1.0	2.4
Heart disease (siblings)	2.0	2.5	4.2	2.0	1.6	0.8
Medication: Metformin	1.9	2.7	6.1	-0.5	1.3	2.5
Medication: Ramipril	1.9	2.4	5.1	1.4	2.3	0.5
Medication for cholesterol	1.9	2.9	7.4	-0.2	-2.7	-1.1
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.3	4.4	-1.6	-2.1	0.4
Gout (self-reported)	1.8	2.5	6.4	0.9	2.5	-0.4
Illnesses of father: High blood pressure	1.8	2.2	5.6	0.8	2.4	0.5
Medication: Omeprazole (e.g. Zanprol)	1.8	2.2	2.5	1.6	1.4	1.4
Age when periods started (menarche)	1.7	4.1	6.2	2.0	2.5	1.5
Medication for cholesterol, blood pressure or diabetes	1.7	2.7	6.7	-0.8	-2.6	-0.9
Number of children fathered	1.7	1.9	3.7	-0.2	-1.4	-1.9
Mean time to correctly identify matches	1.7	3.2	5.5	-2.3	-1.6	1.2
Osteoporosis (self-reported)	1.7	2.1	4.9	2.2	1.1	0.0
Type 2 Diabetes (T2D) (2018)	1.6	3.1	5.9	-2.4	1.1	1.5
Taking other prescription medications	1.6	2.5	7.1	0.2	2.7	0.5
Alcohol usually taken with meals	1.6	2.6	6.2	-0.0	-2.5	1.3
Number of full sisters	1.6	2.0	2.8	1.7	1.0	1.5
Osteoarthritis (self-reported)	1.6	2.0	5.1	0.7	2.2	0.7
Ever depressed for a whole week	1.6	2.0	2.7	-1.4	-1.1	-1.6
Sensitivity / hurt feelings	1.5	2.6	5.1	1.5	2.3	0.7
Pain all over the body in last month	1.5	1.6	4.2	0.5	2.0	0.7
Impedance of arm (right)	1.5	7.2	13.1	0.4	-2.9	-3.6
Impedance of arm (left)	1.5	6.8	14.9	1.2	-2.0	-3.9
Birth weight of first child	1.5	2.8	6.1	1.3	0.8	2.5
Emphysema/chronic bronchitis	1.5	1.7	4.4	2.1	0.2	0.8
Commuting to job workplace: Cycle	1.5	1.8	4.0	-2.0	-0.9	-0.9
Pack years of smoking	1.5	2.2	4.2	0.9	2.0	1.3
Bipolar Disorder (2018)	1.4	2.3	4.0	2.0	1.4	0.9
Reaction Time	1.4	2.6	6.4	-2.5	-1.1	0.6
Average weekly fortified wine intake	1.4	1.6	4.4	0.1	-2.1	0.6
Financial difficulties in last 2 years	1.4	1.9	2.3	1.5	1.4	1.2
Diabetes (self-reported)	1.4	2.1	2.6	-1.6	1.2	1.5
Noisy workplace	1.4	1.7	3.7	0.4	1.1	1.9
Alcohol intake frequency.	1.4	3.2	6.7	-2.6	1.6	-0.6
Overall health rating	1.4	3.0	4.4	0.5	2.1	2.1
Average weekly champagne plus white wine intake	1.4	1.9	4.9	-0.7	-2.2	0.6
Alcohol drinker status: Never	1.4	1.7	2.3	-1.5	1.3	-1.1
Unable to work because of sickness or disability	1.4	1.8	2.0	1.4	1.1	1.4
Depression (Nagel 2018)	1.3	1.9	5.3	0.7	2.3	0.0
Ovarian Cancer	1.3	1.7	3.6	-1.1	-0.5	-1.9
Mean Putamen Volume	1.3	1.5	3.3	-0.8	-0.8	-1.8
Other serious medical condition/disability diagnosed by doctor	1.3	1.6	4.7	-0.5	2.2	0.1
Townsend deprivation index at recruitment	1.3	1.9	3.4	0.8	1.9	1.2
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	2.9	-1.1	-1.7	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	3.0	0.2	1.7	1.7
Loud music exposure frequency	1.3	1.5	4.1	2.0	0.4	-0.3
Diabetes diagnosed by doctor	1.3	2.2	4.5	-2.1	1.0	1.1
Qualifications: nursing, teaching	1.3	2.0	4.6	0.6	-2.1	1.0
Medication: Gliclazide	1.3	1.4	2.9	0.4	1.7	1.1
Body Mass Index (BMI) (2010)	1.2	1.7	4.7	0.5	2.2	0.3
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	2.5	-1.6	-1.4	-0.5
Headache pain in last month	1.2	2.0	3.6	-1.9	-1.4	-0.6
Back pain experienced in last month	1.2	1.8	4.4	-0.9	0.3	2.1
Medication: Paracetamol	1.2	1.8	2.2	1.1	1.4	1.5
Leg fat percentage (left)	1.2	4.5	10.5	1.5	3.2	0.7
Leg fat mass (left)	1.2	4.6	8.7	1.6	2.9	1.6
Age at First Birth	1.1	1.5	2.4	-0.2	-1.5	-1.5
HDL Cholesterol	1.1	1.8	5.1	2.3	0.4	-0.4
Blood Platelet Count	1.1	12.2	21.3	-4.6	0.1	3.9
BMI	1.1	6.5	14.1	1.2	3.8	1.9
Illnesses of siblings	1.1	1.5	3.6	-0.6	-1.9	-0.7
Ever highly irritable/argumentative for 2 days	1.1	1.4	2.5	-1.6	-1.2	0.4
Arm predicted mass (right)	1.1	5.5	13.0	0.8	1.7	3.6
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.4	2.2	1.2	0.6	1.5
Mood swings	1.1	2.0	6.0	-2.4	-0.1	-0.1
Average weekly beer plus cider intake	1.1	1.6	2.1	0.9	1.4	1.4
HbA1C	1.0	1.2	2.9	-0.4	0.6	1.7
Frequency of depressed mood in last 2 weeks	1.0	1.4	3.6	0.4	1.9	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	3.8	0.5	1.9	-0.3
Medication: Atenolol	1.0	1.2	3.2	-0.6	1.8	-0.4
Exposure to tobacco smoke at home	1.0	1.1	2.8	-0.3	0.7	1.7
High blood pressure (siblings)	1.0	1.4	3.3	0.7	1.8	-0.7
Leg fat percentage (right)	1.0	3.7	9.0	1.3	3.0	0.6
Arm fat-free mass (right)	1.0	5.0	11.6	0.7	1.7	3.4
Medication: Omeprazole	1.0	1.3	2.2	1.0	0.8	1.5
Had major operations	1.0	1.1	2.2	0.9	1.5	0.6
Age at last live birth	1.0	1.5	4.1	2.0	-0.5	0.5
Average weekly red wine intake	1.0	1.5	2.3	1.4	-1.5	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	3.2	-0.6	-0.1	1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	5.3	1.0	2.3	-0.4
Arm predicted mass (left)	1.0	4.9	13.4	0.1	1.1	3.7
Medication for hormone replacement therapy	0.9	1.0	1.2	0.9	-0.9	1.1
Chronic bronchitis/emphysema (father)	0.9	1.0	3.0	0.2	-0.2	1.7
Qualifications: A levels/AS levels or equivalent	0.9	2.0	5.4	-0.8	-2.3	0.1
Leg fat mass (right)	0.9	3.7	7.1	1.3	2.7	1.5
Chest pain or discomfort	0.9	1.2	3.3	0.5	0.4	1.8
Smoking status: Previous	0.9	1.4	2.2	1.5	-0.6	1.3
Long-standing illness, disability or infirmity	0.9	1.4	2.6	-0.6	1.6	1.1
Ever had bowel cancer screening	0.9	1.1	2.0	1.4	0.2	1.0
Wears glasses or contact lenses	0.9	1.0	2.7	-0.6	-1.6	-0.0
Tinnitus: Yes, now most or all of the time	0.9	1.0	2.0	-1.1	-1.4	-0.1
Eye problems/disorders: Glaucoma	0.9	1.0	2.4	0.7	1.5	0.4
Arm fat-free mass (left)	0.9	4.6	12.5	0.1	1.1	3.5
Pain experienced in last month	0.9	1.5	4.4	-0.3	0.2	-2.1
Impedance of whole body	0.9	4.4	10.9	1.2	-0.9	-3.3
Breast Cancer	0.8	1.9	4.5	0.9	-2.1	-0.6
Lung FVC	0.8	4.2	8.9	1.7	3.0	-0.8
Number of treatments/medications taken	0.8	1.4	3.8	0.6	1.9	0.1
Relative age of first facial hair	0.8	1.7	2.4	1.5	1.5	-0.6
Trunk fat percentage	0.8	3.0	4.7	2.2	2.0	-0.5
Hayfever, allergic rhinitis or eczema	0.8	1.7	3.3	-1.8	-1.0	-0.8
Trunk fat-free mass	0.8	4.7	14.1	0.0	-0.1	3.8
Hip circumference	0.8	3.5	4.5	1.9	2.1	1.5
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.5	-0.0	-0.4	1.6
Trunk predicted mass	0.8	4.6	13.8	-0.1	-0.2	3.7
Body fat percentage	0.8	3.2	5.4	2.0	2.3	-0.3
Worry too long after embarrassment	0.8	1.3	2.7	-0.9	-0.5	1.6
Age at first live birth	0.8	1.5	3.1	1.8	-0.7	-0.9
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.2	1.5	0.4	0.5
Illnesses of father: Heart disease	0.8	1.1	1.8	-0.9	-0.8	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	2.4	1.6	0.7	1.5
Ever taken oral contraceptive pill	0.8	0.9	2.2	-0.6	-1.5	-0.1
Schizophrenia vs Biploar Disorder	0.7	1.0	2.1	-0.2	-1.5	-0.9
LDL Cholesterol	0.7	1.1	2.1	0.0	1.0	-1.5
Hearing difficulty/problems: Yes	0.7	1.0	2.1	1.5	0.7	0.7
Ever used hormone-replacement therapy (HRT)	0.7	1.0	2.4	1.6	0.3	0.6
Serious illness, injury or assault to yourself	0.7	0.8	2.3	-0.4	0.2	1.5
Supplements: Glucosamine	0.7	0.9	1.4	1.2	-0.2	1.1
Body mass index (BMI)	0.7	2.9	6.9	0.8	2.6	1.0
Hair/balding pattern: Pattern 2	0.7	0.8	1.1	-0.8	-0.9	-1.1
Time employed in main current job	0.7	0.8	1.0	-0.7	-0.9	1.0
Alcohol intake versus 10 years previously	0.7	1.1	1.4	-1.2	0.9	1.0
Glaucoma (self-reported)	0.7	0.8	2.1	0.1	1.4	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.0	-0.7	1.4	0.4
Migraine (self-reported)	0.7	0.9	1.0	-0.9	-0.8	-1.0
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.3	1.0	1.2	-0.2
Cholesterol lowering medication	0.7	1.1	2.8	0.3	1.7	0.5
Major Depression (MDD)	0.6	0.7	2.0	-0.2	1.4	-0.4
Triglycerides	0.6	1.0	2.8	-0.2	1.7	0.4
Blood Eosinophil Count	0.6	4.3	8.2	-2.9	0.5	-2.1
Chronotype (morning person)	0.6	1.3	1.8	1.4	0.7	1.3
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.3	0.8	-0.1	1.1
Stomach or abdominal pain in last month	0.6	0.7	1.7	1.3	0.7	0.2
Trunk fat mass	0.6	2.6	4.3	2.1	1.8	0.6
Past tobacco smoking	0.6	1.1	1.7	-1.1	0.6	-1.3
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	2.3	0.4	1.5	0.5
Had other major operations	0.6	0.8	1.2	1.0	1.1	-0.4
Forced vital capacity (FVC)	0.6	2.2	4.2	2.1	1.0	1.1
Weight	0.6	2.9	4.4	1.2	1.6	2.1
Father’s age at death	0.6	0.8	1.0	-0.9	-1.0	0.8
Falls in the last year	0.6	0.8	1.9	-0.2	-0.8	-1.4
Asthma	0.6	1.2	3.0	-1.7	-0.7	0.3
Illnesses of mother	0.6	0.7	1.9	-0.5	-1.4	-0.3
Tense / ‘highly strung’	0.6	1.0	2.5	-0.5	1.6	0.4
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	1.5	-1.1	-1.2	-0.1
Medication for pain relief, constipation, heartburn	0.6	1.0	2.0	-0.5	-0.8	-1.4
Family relationship satisfaction	0.6	0.7	1.2	1.1	0.4	0.9
Whole body fat-free mass	0.6	3.6	10.6	-0.2	0.1	3.3
Asthma (self-reported)	0.6	1.1	2.9	-1.7	-0.6	0.4
Whole body water mass	0.6	3.6	10.6	-0.0	0.2	3.3
Basal metabolic rate	0.6	3.5	10.0	0.4	0.7	3.2
Alcohol drinker status: Previous	0.6	0.6	1.0	-1.0	0.5	0.8
Bipolar Disorder or Schizophrenia	0.5	1.2	3.3	1.8	0.1	0.4
Alzheimer’s Disease (in father)	0.5	0.6	1.2	0.3	-1.1	0.7
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.0	1.1	0.4	-1.4
Coronary Artery Disease (CAD)	0.5	0.6	1.4	1.2	0.2	0.5
Crohns Disease (2012)	0.5	0.8	1.7	0.7	1.3	0.5
Fasting Glucose	0.5	0.6	1.6	0.1	-0.0	1.3
Rheumatoid Arthritis	0.5	0.7	2.0	0.4	1.4	-0.4
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.3	1.2	-0.4	-0.4
Ever had hysterectomy (womb removed)	0.5	0.5	1.4	0.3	1.2	0.2
Hand grip strength (right)	0.5	1.3	2.6	-1.0	-1.6	0.4
Fed-up feelings	0.5	0.9	1.9	-1.4	0.9	0.3
Relative age voice broke	0.5	0.7	1.8	1.4	0.5	0.4
Qualifications: CSEs or equivalent	0.5	0.7	1.5	0.3	0.7	-1.2
Waist circumference	0.5	1.8	2.3	1.0	1.4	1.5
Heart attack	0.5	0.6	0.8	0.9	0.7	0.7
Depression (self-reported)	0.5	0.7	1.6	-0.6	1.3	-0.2
Medication: Lansoprazole	0.5	0.6	1.0	-0.8	-0.3	-1.0
Pulse wave reflection index	0.5	0.6	0.9	0.8	1.0	0.5
Number of full brothers	0.5	0.6	1.0	0.0	0.9	1.0
Wheeze or whistling in the chest in last year	0.5	0.9	2.2	0.0	0.8	1.5
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.4	-0.6	-1.2	0.3
Whole body fat mass	0.5	2.2	3.5	1.7	1.9	0.7
Comparative height size at age 10	0.5	2.7	6.5	-1.2	-2.5	-0.5
Arm fat percentage (left)	0.5	2.0	3.1	1.5	1.8	-0.9
Guilty feelings	0.5	0.7	1.4	0.7	1.2	0.5
Ever smoked	0.5	0.9	2.4	0.0	-1.5	0.7
Irritability	0.5	0.8	1.4	-1.2	-0.8	-0.5
Depressed Affect (Nagel 2018)	0.4	0.8	1.3	-0.9	1.1	0.6
Alzheimer’s Disease (in mother)	0.4	0.4	0.7	-0.7	-0.4	-0.8
Lupus	0.4	0.5	0.9	0.5	0.7	1.0
Allergy or Eczema	0.4	1.0	2.0	-1.0	-1.4	-0.2
Average weekly spirits intake	0.4	0.6	1.5	-0.3	-1.2	-0.3
Diabetes (mother)	0.4	0.6	1.1	-0.0	0.7	1.1
Severe depression (siblings)	0.4	0.5	0.7	-0.7	-0.8	0.5
Leg fat-free mass (left)	0.4	2.0	6.0	0.1	0.3	2.4
Leg predicted mass (left)	0.4	1.9	5.6	-0.0	0.3	2.4
Had menopause	0.4	0.5	0.6	0.7	-0.8	-0.6
Medication: Simvastatin	0.4	0.6	1.4	-0.6	1.2	-0.2
Fluid intelligence score	0.4	0.8	1.3	1.1	0.2	-1.0
Neuroticism score	0.4	0.8	1.3	-1.2	1.1	0.0
Medication: Cholesterol lowering	0.4	0.6	1.5	-1.2	0.4	-0.3
Prospective memory result	0.4	0.5	0.9	0.3	1.0	0.7
Lung cancer (father)	0.4	0.5	0.9	0.8	0.9	0.3
Medication: Paracetamol	0.4	0.6	1.0	0.4	0.8	1.0
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.1	-0.8	1.1	-0.7
Medication: Ventolin 100micrograms inhaler	0.4	0.5	0.9	-0.5	-0.6	-0.9
Forced vital capacity (FVC), Best measure	0.4	1.6	3.3	1.8	0.6	1.1
Comparative body size at age 10	0.4	1.2	2.9	-0.8	-1.7	-0.0
Shortness of breath walking on level ground	0.4	0.5	1.1	1.1	0.4	0.3
Qualifications: College or University degree	0.4	1.2	2.5	0.8	-1.6	0.7
Suffer from ‘nerves’	0.4	0.6	1.6	-0.3	1.3	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	0.7	0.6	0.6	0.9
Leg fat-free mass (right)	0.4	2.1	6.4	-0.0	0.3	2.5
Loneliness, isolation	0.4	0.5	1.1	-1.0	0.4	0.6
Eye problems/disorders: Cataract	0.4	0.5	0.8	0.6	0.9	0.5
Leg predicted mass (right)	0.4	2.3	6.7	0.2	0.4	2.6
Arm fat mass (left)	0.4	1.5	2.7	1.2	1.7	0.4
High cholesterol (Self-reported)	0.4	0.7	1.4	-1.2	0.8	-0.5
Medication: Atorvastatin	0.4	0.5	0.8	-0.9	0.7	-0.3
Ever had prostate specific antigen (PSA) test	0.4	0.5	0.8	0.5	0.7	0.9
Myopia	0.4	0.6	1.0	0.8	-1.0	0.0
Schizophrenia (2018)	0.3	0.6	1.1	0.7	-1.0	-0.2
Prostate Cancer	0.3	0.4	1.3	0.0	0.3	-1.1
Ulcerative Colitis	0.3	0.4	0.8	-0.2	-0.9	0.5
Height	0.3	6.3	13.7	0.1	-2.3	3.7
Waist Hip Ratio (WHR)	0.3	1.4	2.6	-0.8	-1.6	1.0
Smoking Status	0.3	0.8	2.2	0.4	-1.5	0.0
Hypothyroidism (self reported)	0.3	0.8	2.0	0.1	1.4	0.5
Respiratory disease	0.3	0.6	1.2	-0.4	-0.7	1.1
Tanning	0.3	3.4	10.0	0.2	-3.2	-0.4
Hand grip strength (left)	0.3	0.8	2.1	-0.4	-1.4	0.2
Supplements: Zinc	0.3	0.4	0.6	-0.4	-0.8	-0.6
Impedance of leg (right)	0.3	1.6	3.8	1.0	0.2	-1.9
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.7	-0.8	0.6	-0.3
Medication: Levothyroxine sodium	0.3	0.4	1.2	-0.3	1.1	0.0
Sitting height	0.3	2.1	6.1	-0.3	-0.4	2.5
Impedance of leg (left)	0.3	1.7	2.3	1.5	0.9	-1.4
Allergy	0.3	0.6	1.7	1.3	-0.3	-0.1
Arm fat percentage (right)	0.3	1.0	1.3	1.1	1.1	-0.7
Worrier / anxious feelings	0.3	0.6	1.1	-1.0	-0.6	0.6
Pulse rate	0.3	0.5	1.3	0.1	0.4	1.1
Mouth/teeth dental problems: Dentures	0.3	0.5	1.5	-0.1	0.1	1.2
Pulse wave Arterial Stiffness index	0.3	0.3	0.8	-0.2	-0.3	0.9
Arm fat mass (right)	0.3	1.1	2.0	1.0	1.4	0.5
Standing height	0.3	3.4	5.5	1.3	-1.8	2.4
Medication: Seretide 50 evohaler	0.3	0.3	0.7	-0.3	-0.5	-0.8
Friendships satisfaction	0.3	0.3	0.5	0.6	-0.2	0.7
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.7	-0.8	0.1	0.7
Number of operations (self-reported)	0.3	0.5	1.0	-0.4	0.6	-1.0
Age started oral contraceptive pill	0.3	0.4	0.4	0.6	-0.6	-0.6
Supplements: Calcium	0.3	0.3	0.6	-0.2	-0.6	-0.8
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.7	0.8	0.6	0.4
Worry (Nagel 2018)	0.2	0.4	0.6	-0.7	0.0	-0.8
Crohns Disease (2017)	0.2	0.4	1.2	-0.1	1.1	0.1
Schizophrenia (2014)	0.2	0.4	0.7	0.6	-0.8	-0.1
Neuroticism	0.2	0.6	1.4	-1.2	0.5	-0.1
Maternal smoking around birth	0.2	0.3	0.5	-0.6	-0.7	-0.3
Number of incorrect matches in round	0.2	0.4	0.6	0.1	0.8	0.7
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	0.9	1.0	0.9	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	0.9	0.8	0.6	1.0
Exposure to tobacco smoke outside home	0.2	0.2	0.5	-0.4	-0.7	0.2
Pulse wave peak to peak time	0.2	0.2	0.5	0.3	0.2	-0.7
Supplements: Vitamin C	0.2	0.3	0.6	-0.1	0.5	0.8
Mineral and other dietary supplements	0.2	0.3	0.8	-0.0	-0.1	-0.9
Illnesses of father: None of the above (group 1)	0.2	0.2	0.5	0.4	0.2	0.7
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.5	0.7	0.2	-0.2
Neuroticism (Nagel 2018)	0.1	0.2	0.5	-0.2	0.7	0.3
Alzheimer’s Disease (including proxy)	0.1	0.1	0.1	-0.2	-0.3	-0.3
Ulcerative Colitis (UC)	0.1	0.2	0.5	0.3	0.0	0.7
Neuroticism (2016)	0.1	0.2	0.6	-0.0	0.8	-0.0
Hair Pigment	0.1	3.4	6.9	2.6	1.0	1.5
Angina	0.1	0.1	0.3	0.1	0.0	-0.5
Vitamin and mineral supplements	0.1	0.1	0.1	0.1	-0.3	-0.3
Diabetes (father)	0.1	0.1	0.2	-0.4	0.4	-0.3
Current tobacco smoking	0.1	0.2	0.2	-0.4	-0.4	0.4
Nervous feelings	0.1	0.2	0.6	-0.2	0.8	0.2
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.1	0.1	0.4	-0.4
Happiness	0.1	0.2	0.5	-0.1	0.7	-0.0
Hair/balding pattern: Pattern 4	0.1	0.4	0.6	0.6	-0.7	-0.3
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.3	0.1	-0.0	-0.5
Health satisfaction	0.1	0.1	0.2	0.3	-0.3	0.4
Eye problems/disorders: None of the above	0.1	0.1	0.3	0.3	0.1	0.5
Angina (self-reported)	0.1	0.1	0.2	0.5	0.3	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.4	-0.2	-0.6	0.1
Knee pain experienced in last month	0.1	0.2	0.4	0.4	0.1	0.6
Commuting to job workplace: Walk	0.1	0.1	0.1	0.4	-0.2	0.0
Smoking status: Current	0.1	0.1	0.1	-0.3	-0.4	0.2
Commuting to job workplace: Public transport	0.1	0.1	0.3	-0.3	-0.5	0.3
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.3	0.5	-0.1	0.4
Fractured/broken bones in last 5 years	0.1	0.1	0.3	0.2	0.1	0.6
Irritable Bowel Disease (IBD)	0.0	0.1	0.2	0.0	0.4	0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Multivitamins +/- minerals	0.0	0.1	0.1	0.4	0.2	0.1
Hearing difficulty/problems with background noise	0.0	0.1	0.1	0.4	-0.1	0.2
Peak expiratory flow (PEF)	0.0	0.1	0.2	0.3	0.4	0.0
Birth weight	0.0	0.0	0.0	0.1	-0.0	0.1
Illnesses of siblings: Diabetes	0.0	0.0	0.1	-0.1	0.3	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.1	-0.2	0.1	-0.0
Breast cancer (self-reported)	0.0	0.1	0.1	-0.3	0.1	-0.2
Hearing aid user	0.0	0.0	0.1	0.3	0.0	-0.0
Risk taking	0.0	0.0	0.0	0.1	0.1	0.0

Hub : Genes

LSMD1

Models

Trait associations