Hub : Genes

ACAP1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 METSIM Adipose 0.0650 0.0221 0.00044 0.028 0.030 0.013 0.025 0.010 4.6e-05 2.5e-05 3.7e-03 1.1e-04 9.4e-03
2 NTR Blood 0.0207 0.0089 0.00340 0.000 0.005 -0.001 0.005 0.000 2.8e-01 6.9e-03 8.2e-01 7.1e-03 3.5e-01
3 YFS Blood 0.3346 0.0318 0.00000 0.208 0.267 0.292 0.290 0.288 3.2e-66 2.0e-87 1.0e-96 4.2e-96 3.5e-95
4 TCGA Breast Invasive Carcinoma 0.0339 0.0166 0.00990 0.021 0.012 0.009 NA 0.010 2.9e-05 1.5e-03 4.1e-03 NA 2.9e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 1.4 2.1 4.1 0.1 1.8 2.0 1.1
Bipolar Disorder or Schizophrenia 1.4 3.5 5.8 1.2 2.1 2.4 1.5
Depressed Affect (Nagel 2018) 0.5 1.1 1.7 -1.1 -1.3 -1.1 -0.3
Depression (Nagel 2018) 0.3 0.4 0.9 0.5 0.9 -0.6 -0.5
Intelligence (Savage-Jansen 2018) 0.6 2.0 3.7 -1.7 -1.9 0.9 0.7
Neuroticism (Nagel 2018) 0.6 1.4 2.0 -1.3 -1.1 -1.4 -0.6
Schizophrenia (2018) 0.9 2.0 2.8 1.4 1.3 1.7 1.2
Schizophrenia vs Biploar Disorder 0.2 0.3 1.2 1.1 -0.1 0.0 0.0
Worry (Nagel 2018) 0.3 0.7 2.0 -0.8 1.4 -0.1 -0.0
Alzheimer’s Disease (in mother) 0.2 0.2 0.5 -0.3 0.7 0.5 -0.1
Alzheimer’s Disease (in father) 0.8 0.9 2.1 -0.6 0.6 0.9 -1.5
Alzheimer’s Disease (including proxy) 0.5 0.8 1.5 -0.9 0.1 0.9 -1.2
Crohns Disease (2017) 0.2 0.5 0.7 0.7 -0.8 0.6 0.7
Irritable Bowel Disease (IBD) 0.2 0.4 0.8 -0.5 -0.9 -0.6 -0.5
Ulcerative Colitis (UC) 0.4 0.7 1.4 -1.2 -0.3 -0.8 -0.9
Major Depression (MDD) 0.1 0.1 0.5 -0.7 0.1 0.0 0.0
Reaction Time 1.2 2.3 6.3 0.3 1.6 2.5 -0.6
Verbal and Numeric Reasoning (VNR) 0.3 0.8 2.4 -1.6 -0.8 0.0 0.4
Breast Cancer 1.5 3.5 12.0 1.4 -3.5 -0.5 -0.3
Ovarian Cancer 0.7 1.0 1.3 -1.0 -1.1 -0.9 -0.9
Prostate Cancer 0.1 0.1 0.3 0.0 0.3 0.1 -0.5
Age at First Birth 1.0 1.5 3.7 0.1 1.4 0.6 1.9
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.5 0.7 2.0 -0.9 -0.1 -1.4 0.0
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.3 0.5 1.6 -0.5 -1.3 0.1 0.6
Mean Putamen Volume 0.6 0.7 1.6 0.2 0.9 1.3 0.3
Fasting Glucose 2.4 2.9 5.1 1.4 2.3 0.5 -2.1
HbA1C 0.1 0.1 0.3 0.4 0.2 0.6 -0.2
HDL Cholesterol 2.6 4.3 7.8 -2.3 -1.3 -2.8 -1.5
LDL Cholesterol 1.0 1.6 3.3 1.8 -1.3 1.0 0.0
Lupus 6.9 10.4 17.9 -2.9 -1.9 -3.4 -4.2
Neuroticism (2016) 0.9 1.3 2.9 -1.7 -0.3 -1.2 -0.8
Primary Biliary Cirrhosis 2.8 4.0 7.7 -1.9 -1.2 -1.8 -2.8
Rheumatoid Arthritis 3.4 4.7 11.8 -0.6 -2.0 -3.4 -1.6
Schizophrenia (2014) 1.4 3.1 6.9 1.1 1.2 2.6 1.8
Triglycerides 0.9 1.5 3.5 0.8 1.3 1.9 0.0
Type 2 Diabetes (T2D) (2012) 0.6 0.7 2.8 0.0 0.0 1.7 0.0
Ulcerative Colitis 0.5 0.7 1.5 -0.9 -0.3 0.5 -1.2
Blood Eosinophil Count 2.2 16.6 36.5 2.6 6.0 4.6 1.5
Blood Platelet Count 2.3 26.7 61.9 7.9 2.2 6.2 1.5
Blood Red Count 0.3 2.8 6.1 -2.2 2.5 -0.1 0.2
Blood White Count 3.3 24.4 47.6 3.6 1.2 6.9 6.0
Heel T-Score 0.7 5.4 11.6 3.4 2.6 1.6 -0.8
BMI 0.6 3.3 10.2 0.6 3.2 -1.0 -1.3
Height 0.9 18.3 32.6 -5.7 -4.8 1.5 3.9
Waist Hip Ratio (WHR) 3.3 15.1 32.5 5.7 0.8 4.2 3.0
Systolic Blood Pressure 1.8 9.0 35.3 -0.8 5.9 0.1 0.3
Smoking Status 0.3 0.7 1.9 -1.4 -0.0 -0.6 0.6
Allergy or Eczema 0.4 1.1 1.7 1.3 -0.6 0.8 1.3
Cardiovascular Disease 1.5 5.0 14.6 0.0 3.8 1.4 1.8
Hypothyroidism (self reported) 6.3 14.5 31.2 -1.1 -2.8 -5.6 -4.2
Respiratory disease 2.3 5.2 11.9 3.5 -0.3 2.8 1.0
Type 2 Diabetes (T2D) (2018) 0.6 1.0 1.2 1.1 1.1 1.0 1.0
Lung FEV1/FVC ratio 1.2 6.1 8.2 1.6 2.9 2.8 2.4
Lung FVC 0.1 0.6 1.3 0.1 0.7 -1.1 0.9
Neuroticism 0.3 0.8 0.9 -0.9 0.9 -0.9 0.8
Chronotype (morning person) 0.5 1.2 2.8 -0.9 -0.7 -0.9 -1.7
Hair Pigment 0.1 2.3 3.4 -1.8 -1.8 -1.1 -1.2
Tanning 0.1 1.1 2.2 -1.5 0.1 -0.6 1.4
Hand grip strength (left) 1.0 2.7 7.6 0.1 -1.8 0.2 2.8
Number of treatments/medications taken 0.7 1.3 3.7 -0.6 1.9 -1.0 0.2
Average weekly spirits intake 1.0 1.2 1.9 0.4 1.2 1.1 -1.4
Sensitivity / hurt feelings 1.2 2.0 3.0 -1.0 1.3 -1.7 -1.5
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.4 -0.2 1.2 -0.6 -0.9
Hearing difficulty/problems: Yes 0.9 1.4 3.0 -0.2 -1.7 -1.1 1.1
Relative age of first facial hair 2.2 4.6 8.8 -1.5 0.6 -2.6 -3.0
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 2.0 0.5 -0.5 1.4 -0.1
Ever used hormone-replacement therapy (HRT) 3.3 4.1 6.8 -2.5 -1.4 -2.6 -1.4
Ever had hysterectomy (womb removed) 0.2 0.2 0.5 -0.1 0.7 0.2 -0.4
Systolic blood pressure, automated reading 1.6 4.6 12.3 -1.8 3.5 -1.2 -1.3
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.2 0.0 -0.5 0.2 0.0
Angina 0.1 0.1 0.3 0.4 0.2 0.5 -0.0
Medication for hormone replacement therapy 0.2 0.2 0.5 -0.2 -0.7 -0.5 -0.0
Vitamin and mineral supplements 1.0 1.3 2.4 -1.3 1.1 -0.1 -1.6
Supplements: Zinc 0.3 0.3 0.5 0.6 0.2 -0.7 0.6
Medication: Co-codamol 0.6 0.7 1.4 -1.2 -0.4 -0.5 0.9
Medication: Metformin 0.9 1.3 1.9 1.2 0.4 1.3 1.4
Diabetes (father) 2.0 2.5 5.0 1.5 1.6 2.2 0.3
Diabetes (mother) 0.8 1.0 2.0 1.4 -0.3 -1.4 -0.3
Severe depression (siblings) 0.9 1.0 2.0 0.9 1.4 -0.2 -1.0
Pack years adult smoking proportion 2.1 3.1 8.6 2.9 0.4 1.8 0.8
Impedance of leg (right) 0.2 1.1 2.5 -0.5 -1.1 -1.6 -0.4
Leg fat-free mass (left) 0.2 0.8 1.6 -0.8 1.3 0.8 0.7
Trunk fat percentage 1.2 5.0 9.3 -1.9 3.0 -2.1 -1.6
Hand grip strength (right) 1.4 3.7 10.3 0.7 -1.0 1.8 3.2
Townsend deprivation index at recruitment 1.8 2.6 6.2 -0.3 -1.2 -1.6 -2.5
Current tobacco smoking 0.3 0.5 0.7 0.4 -0.7 0.8 0.8
Average weekly fortified wine intake 0.4 0.4 0.9 0.6 0.5 1.0 -0.3
Maternal smoking around birth 0.2 0.3 1.0 -0.1 0.1 1.0 0.5
Fed-up feelings 2.2 4.1 8.2 -1.6 -2.0 -2.9 -1.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 1.0 0.1 0.1 -1.0 -1.0
Relative age voice broke 0.9 1.4 3.5 0.5 0.9 -1.1 -1.9
Taking other prescription medications 0.4 0.6 1.9 0.1 0.7 -1.4 -0.2
Age when periods started (menarche) 0.5 1.2 2.2 1.5 1.2 0.7 -0.8
Bilateral oophorectomy (both ovaries removed) 0.8 1.0 3.7 0.0 -1.9 0.0 0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.4 3.0 1.7 -0.2 0.9 -1.3
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 1.4 -0.4 -0.7 -1.2 -0.9
Qualifications: CSEs or equivalent 0.7 0.9 2.5 -0.1 0.0 1.1 1.6
Serious illness, injury or assault to yourself 1.8 2.2 8.1 2.8 0.1 0.6 0.4
High blood pressure 1.5 4.0 11.0 -2.1 3.3 -0.4 0.9
Hayfever, allergic rhinitis or eczema 0.3 0.7 1.3 1.1 -0.7 0.2 1.0
Multivitamins +/- minerals 1.6 2.0 5.4 2.3 0.5 0.3 1.5
Stomach or abdominal pain in last month 0.6 0.7 1.8 -1.3 0.8 -0.2 -0.6
Supplements: Glucosamine 0.7 0.9 1.5 0.9 0.4 -1.2 -1.1
Diverticular disease/diverticulitis (self-reported) 1.7 2.0 7.5 -0.5 0.2 -2.7 -0.4
Medication: Atenolol 1.9 2.3 8.4 -0.6 2.9 -0.7 -0.2
Medication: Levothyroxine sodium 4.8 8.1 17.0 -0.4 -2.8 -4.1 -2.7
Sitting height 0.7 5.1 12.9 -3.6 -1.5 -0.5 2.2
Chronic bronchitis/emphysema (father) 0.3 0.4 1.2 0.5 0.1 0.0 -1.1
High blood pressure (mother) 3.1 4.3 16.3 -0.6 4.0 0.5 -0.6
Body mass index (BMI) 0.8 3.5 12.0 0.2 3.5 -0.4 -1.3
Impedance of leg (left) 0.2 0.9 2.0 -0.5 -1.1 -1.4 0.4
Leg predicted mass (left) 0.2 0.8 1.6 -0.8 1.3 0.7 0.6
Trunk fat mass 0.8 3.3 7.1 -1.6 2.7 -1.6 -0.9
Waist circumference 0.8 3.0 10.6 0.8 3.3 0.6 -0.4
Number of incorrect matches in round 1.1 1.8 3.8 -1.9 -1.2 -1.4 0.1
Past tobacco smoking 0.9 1.7 2.7 1.7 1.1 0.8 -1.4
Alcohol usually taken with meals 0.4 0.7 1.7 0.5 -1.3 0.7 0.6
Nervous feelings 0.1 0.1 0.3 0.1 0.1 -0.5 -0.5
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.7 1.0 0.5 1.0 -0.8 -1.0
Hearing difficulty/problems with background noise 0.2 0.4 1.2 0.1 -1.1 0.0 0.5
Hair/balding pattern: Pattern 2 1.8 2.3 5.0 2.2 1.0 0.9 1.6
Had menopause 5.5 6.8 14.6 -3.4 -3.8 -1.0 -0.2
Had other major operations 2.4 2.9 8.8 -3.0 -0.0 -1.5 0.9
Forced vital capacity (FVC) 1.2 4.5 7.6 -1.4 -2.8 -1.2 2.6
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.8 5.2 2.3 1.0 1.0 -0.2
Ever unenthusiastic/disinterested for a whole week 1.4 1.7 5.0 -2.2 -0.3 -1.2 -0.4
Qualifications: None of the above 0.5 1.0 2.4 0.1 0.2 -1.5 -1.2
Financial difficulties in last 2 years 0.3 0.4 1.2 0.6 0.2 1.1 -0.0
Mouth/teeth dental problems 0.4 0.5 1.0 0.8 -0.1 -0.7 -1.0
Heart attack 1.7 2.2 6.2 2.5 -0.5 1.1 -0.9
Allergy 0.7 1.6 3.6 -1.9 0.7 -0.8 -1.3
Pain all over the body in last month 1.8 1.9 2.6 -1.1 -1.2 -1.6 -1.5
Diabetes (self-reported) 0.2 0.4 1.1 0.3 0.5 -0.1 1.0
Hayfever/allergic rhinitis (self-reported) 2.1 2.8 5.8 1.9 0.8 1.0 2.4
Medication: Ramipril 1.2 1.5 5.5 -0.0 2.3 0.1 0.7
Medication: Simvastatin 2.0 2.9 5.2 1.0 2.3 0.8 2.2
Fluid intelligence score 0.1 0.1 0.3 -0.0 -0.5 0.4 -0.1
Illnesses of siblings 0.4 0.5 1.3 0.3 0.3 1.1 -0.7
Neuroticism score 0.2 0.5 0.8 -0.2 0.9 -0.8 -0.6
Weight 0.3 1.6 4.1 -1.5 2.0 -0.2 0.3
Impedance of arm (right) 0.6 2.8 5.5 -2.3 -0.4 -2.1 -1.0
Arm fat percentage (right) 1.3 5.3 13.9 -0.8 3.7 -1.6 -2.0
Trunk fat-free mass 0.3 1.7 4.3 -0.3 0.0 1.5 2.1
Hip circumference 1.4 5.9 8.8 -3.0 2.6 -1.8 -2.2
Time employed in main current job 1.7 2.0 3.7 1.3 -1.5 1.9 0.7
Alcohol intake versus 10 years previously 1.2 1.8 6.6 0.8 -2.6 0.2 0.2
Father’s age at death 0.5 0.6 1.0 1.0 -1.0 -0.2 0.8
Worrier / anxious feelings 0.6 1.1 3.2 0.1 1.0 0.3 -1.8
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.4 4.1 -0.5 1.0 -0.3 -2.0
Falls in the last year 1.5 2.1 6.5 -0.6 1.0 2.6 0.5
Hair/balding pattern: Pattern 3 0.2 0.4 1.1 0.1 -0.5 -0.4 -1.1
Number of live births 0.1 0.1 0.3 -0.1 -0.3 0.5 -0.4
Forced expiratory volume in 1-second (FEV1) 1.1 3.7 8.2 -1.2 -2.1 -1.0 2.9
Pulse rate 0.3 0.5 1.1 0.6 -0.6 1.0 0.2
Happiness 1.2 1.4 2.5 -1.6 -0.6 -1.6 -0.5
Noisy workplace 0.7 0.9 2.1 0.1 -0.7 0.9 1.5
Qualifications: A levels/AS levels or equivalent 0.4 0.9 1.4 0.9 -1.2 1.1 -0.1
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.2 4.0 -0.5 0.7 -2.0 -0.5
Mouth/teeth dental problems: Dentures 0.6 1.0 3.6 -0.5 -1.9 0.2 0.1
Asthma 2.3 4.6 8.4 2.9 0.3 2.9 1.2
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.6 1.4 -0.9 1.2 0.1 0.3
Medication: Cholesterol lowering 1.9 2.9 3.6 1.7 1.9 1.8 1.3
Depression (self-reported) 0.3 0.4 1.3 -0.3 1.1 0.0 0.1
Medication: Lansoprazole 0.8 0.9 3.6 0.2 1.9 0.3 -0.2
Prospective memory result 0.4 0.5 1.2 -1.1 -0.2 -0.9 0.0
Lung cancer (father) 0.9 1.0 2.9 -0.3 0.1 -1.7 -1.0
Illnesses of mother 1.6 2.0 6.0 -1.3 -2.5 -0.6 0.0
Forced expiratory volume in 1-second (FEV1), Best measure 1.2 3.8 9.9 -1.4 -1.8 -0.5 3.1
Pulse wave Arterial Stiffness index 0.3 0.4 1.2 1.1 0.2 0.6 0.0
Impedance of arm (left) 0.7 3.2 7.9 -2.8 -0.8 -1.7 -1.1
Arm fat mass (right) 0.9 3.7 9.8 -1.2 3.1 -1.2 -1.4
Trunk predicted mass 0.3 1.7 4.5 -0.3 -0.0 1.5 2.1
Standing height 0.8 8.4 14.5 -3.8 -2.7 0.6 3.3
Length of working week for main job 1.8 2.0 7.0 -0.2 -2.6 0.9 0.3
Exposure to tobacco smoke at home 1.6 1.8 3.0 1.6 1.0 0.9 -1.7
Breastfed as a baby 0.5 0.6 1.8 -0.5 0.5 0.0 1.3
Tense / ‘highly strung’ 0.3 0.5 1.2 0.4 1.1 -0.2 -0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 1.1 -0.3 0.3 -0.8 1.0
Hair/balding pattern: Pattern 4 1.0 2.4 3.9 0.9 -2.0 -1.4 1.7
Birth weight of first child 0.2 0.3 0.9 0.0 0.6 1.0 -0.4
Peak expiratory flow (PEF) 1.1 2.4 4.7 -0.9 -2.2 -1.4 1.6
Pulse wave reflection index 0.3 0.3 0.5 0.5 0.7 -0.7 0.1
Ever highly irritable/argumentative for 2 days 0.8 0.9 1.9 0.2 1.2 0.5 1.4
Loud music exposure frequency 0.5 0.5 1.5 1.2 0.2 -0.7 0.3
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 2.5 0.0 -0.2 1.6 -0.2
Mouth/teeth dental problems: Bleeding gums 2.9 3.8 5.6 0.6 2.4 2.0 2.2
Blood clot in the leg (DVT) 1.2 1.6 4.1 -2.0 0.2 -1.4 0.2
Medication: Paracetamol 0.6 0.9 1.5 0.6 1.2 1.0 1.0
Headache pain in last month 2.0 3.5 6.7 1.6 2.0 2.6 0.7
Medication for cholesterol, blood pressure or diabetes 2.3 3.9 10.2 -1.1 -3.2 -1.2 -1.6
Glaucoma (self-reported) 1.8 2.1 7.5 0.0 -0.7 0.7 2.7
Gout (self-reported) 1.1 1.5 4.6 0.2 2.1 -1.2 -0.2
Hypothyroidism/myxoedema (self-reported) 6.5 12.7 26.4 -1.4 -2.3 -5.1 -4.2
Medication: Amlodipine 1.8 2.5 9.9 -0.4 3.1 0.1 0.2
Medication: Ventolin 100micrograms inhaler 2.2 2.8 5.9 1.4 -0.1 1.8 2.4
Birth weight 11.9 25.8 54.9 3.0 7.4 5.4 3.2
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.5 0.1 0.7 -0.5 -0.1
High blood pressure (siblings) 1.1 1.6 5.9 -2.4 0.5 -0.5 0.4
Forced vital capacity (FVC), Best measure 1.1 4.1 8.6 -1.6 -2.3 -0.3 2.9
Body fat percentage 1.3 5.1 10.0 -1.3 3.2 -2.2 -2.0
Leg fat percentage (right) 1.2 4.3 8.9 0.1 3.0 -2.0 -2.1
Arm fat-free mass (right) 0.2 0.9 2.4 -0.4 0.2 1.0 1.6
Exposure to tobacco smoke outside home 1.2 1.6 4.0 1.0 1.2 0.3 -2.0
Comparative body size at age 10 2.0 5.6 13.8 -1.6 -0.2 -2.4 -3.7
Number of full brothers 0.2 0.2 0.4 0.6 0.2 -0.5 -0.3
Worry too long after embarrassment 0.2 0.4 0.8 -0.8 -0.9 0.1 0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 1.0 -0.9 -0.4 -1.0 -0.8
Wheeze or whistling in the chest in last year 1.2 2.1 3.9 2.0 -1.5 1.4 0.6
Number of children fathered 2.0 2.2 8.5 -0.1 -0.3 0.6 2.9
Reason for reducing amount of alcohol drunk: Health precaution 1.5 1.7 4.5 -0.7 -1.4 -0.3 -2.1
Age at first live birth 0.4 0.7 1.4 -0.2 0.7 -1.2 0.8
Pulse wave peak to peak time 0.6 0.7 2.0 -1.4 -0.5 -0.7 -0.0
Health satisfaction 0.2 0.2 0.7 -0.8 -0.5 -0.0 -0.1
Shortness of breath walking on level ground 1.2 1.4 4.0 -0.3 -1.1 -0.4 -2.0
Qualifications: College or University degree 1.1 3.4 6.0 -1.6 -2.5 -1.6 -1.5
Eye problems/disorders: None of the above 1.1 1.2 2.8 1.2 0.1 -0.8 -1.7
Mouth/teeth dental problems: Loose teeth 1.2 1.4 3.5 0.4 1.9 0.6 1.2
Emphysema/chronic bronchitis 1.5 1.7 2.5 1.6 1.5 0.9 1.1
Medication for pain relief, constipation, heartburn 0.8 1.4 4.7 0.7 -2.2 0.6 0.2
Neck or shoulder pain in last month 0.3 0.4 0.8 -0.6 -0.9 -0.6 0.1
Medication: Blood pressure 2.5 4.4 17.1 -0.4 4.1 -0.3 0.3
Angina (self-reported) 0.1 0.1 0.2 0.0 -0.3 0.3 -0.4
Migraine (self-reported) 1.8 2.3 5.5 0.9 2.4 1.6 0.4
Medication: Ibuprofen 0.4 0.4 1.0 -0.7 1.0 -0.0 0.4
Medication: Allopurinol 0.7 0.9 2.3 0.3 1.5 -0.9 0.7
Medication: Omeprazole 0.2 0.3 0.8 0.5 -0.9 0.0 0.3
Medication: Seretide 50 evohaler 1.5 1.7 4.4 0.6 1.2 -0.9 -2.1
Mean time to correctly identify matches 0.8 1.4 4.8 0.1 0.9 2.2 -0.4
Heart disease (mother) 0.5 0.5 2.0 -0.0 0.2 -0.4 1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 2.0 0.3 -0.9 -1.4 -1.2
Whole body fat mass 0.8 3.4 7.3 -1.3 2.7 -1.5 -1.4
Leg fat mass (right) 0.7 2.9 6.9 -0.3 2.6 -1.5 -1.6
Arm predicted mass (right) 0.2 0.8 2.0 -0.2 0.1 1.1 1.4
Pulse rate, automated reading 1.2 3.9 9.2 3.0 -1.9 1.1 1.4
Alcohol intake frequency. 0.1 0.1 0.3 0.4 0.2 0.2 -0.5
Comparative height size at age 10 0.7 3.9 9.4 -3.1 -0.9 -0.9 2.1
Number of full sisters 0.3 0.3 0.8 0.1 0.2 0.7 0.9
Suffer from ‘nerves’ 1.1 1.8 4.5 0.7 2.1 1.4 -0.6
Overall health rating 0.4 0.8 2.4 1.6 0.4 0.5 -0.5
Chest pain or discomfort 2.4 3.5 7.7 2.8 0.3 2.4 0.4
Had major operations 0.4 0.4 1.3 1.1 0.5 -0.5 0.1
Age at last live birth 0.4 0.6 1.7 -0.1 -0.7 -1.3 0.3
Family relationship satisfaction 0.6 0.8 1.7 -1.3 -0.6 -1.0 0.3
Leg pain on walking 0.5 0.6 1.5 0.3 -1.2 1.0 0.1
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.4 1.5 1.2 0.1 0.5 0.3
Commuting to job workplace: Car/motor vehicle 0.8 0.9 2.5 0.1 0.3 1.0 -1.6
Illness, injury, bereavement, stress in last 2 years 1.9 2.3 5.8 -2.4 0.5 -1.4 -1.0
Medication: Aspirin 1.3 1.7 3.4 -0.3 1.9 -1.1 -1.4
Supplements: Vitamin C 0.3 0.4 0.8 -0.2 -0.8 0.9 0.2
Knee pain experienced in last month 0.3 0.4 1.1 -0.2 0.6 -0.3 -1.0
Hypertension (Self-reported) 1.4 3.9 9.5 -2.3 3.1 -0.5 0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.5 1.7 3.0 0.4 1.1 1.7 1.6
Illnesses of father: Heart disease 1.0 1.4 2.5 1.1 1.6 -1.1 0.9
Illnesses of siblings: Diabetes 1.9 2.3 7.0 2.6 1.0 -0.7 -0.8
Smoking status: Previous 0.8 1.2 2.2 -1.5 -0.9 -0.9 0.9
Forced expiratory volume in 1-second (FEV1), predicted 1.3 2.8 5.5 -0.3 -0.5 2.3 2.3
Whole body fat-free mass 0.2 1.0 2.2 -0.5 0.5 1.2 1.5
Leg fat-free mass (right) 0.2 1.1 1.3 -0.8 1.1 1.1 1.1
Arm fat percentage (left) 1.3 5.2 13.2 -1.0 3.6 -1.6 -2.0
Average weekly red wine intake 0.6 0.9 3.1 0.2 -1.8 0.6 0.5
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.3 0.9 1.1 0.3 0.5
Mood swings 0.1 0.2 0.3 -0.5 0.4 -0.5 -0.5
Loneliness, isolation 0.5 0.7 2.4 0.3 1.6 0.5 -0.1
Long-standing illness, disability or infirmity 0.5 0.8 1.8 0.3 1.2 0.0 -1.3
Ever had bowel cancer screening 1.6 1.8 3.9 -2.0 -1.7 -0.5 0.4
Diabetes diagnosed by doctor 0.3 0.5 1.2 0.6 0.6 0.3 1.1
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.9 2.1 -1.4 0.6 -1.1 0.2
Friendships satisfaction 0.5 0.7 1.8 0.6 -1.4 0.4 0.6
Qualifications: nursing, teaching 0.3 0.5 0.8 0.9 -0.7 0.9 -0.0
Commuting to job workplace: Walk 2.9 3.1 6.2 -1.3 -2.5 -1.9 0.9
Eye problems/disorders: Cataract 0.8 0.9 2.4 -1.6 -0.9 0.7 0.1
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.5 -0.6 -0.4 -0.4 0.7
Medication for cholesterol 0.6 0.9 1.4 1.2 -1.1 -0.2 -0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.3 1.5 2.2 1.4 1.3 1.5 -0.3
Back pain experienced in last month 0.3 0.4 0.7 -0.4 -0.8 0.1 0.9
Mineral and other dietary supplements 0.3 0.4 1.3 -1.1 0.2 0.4 0.0
Breast cancer (self-reported) 1.8 2.1 4.9 0.3 1.0 1.6 2.2
Asthma (self-reported) 2.8 5.6 10.1 3.2 0.1 3.1 1.7
Osteoporosis (self-reported) 0.6 0.8 2.0 1.0 -0.2 -0.1 1.4
Osteoarthritis (self-reported) 2.3 2.9 5.5 -1.6 -1.8 -2.3 0.4
Medication: Aspirin 1.1 1.5 2.8 -0.5 1.7 -1.1 -1.3
Medication: Gliclazide 0.5 0.6 1.2 -0.5 0.8 0.5 1.1
Illnesses of father: None of the above (group 1) 1.7 2.1 7.5 -0.1 -2.7 -0.1 0.9
Smoking status: Current 0.1 0.1 0.3 0.2 -0.4 0.2 0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 1.3 -1.1 -0.9 -0.5 -0.1
Whole body water mass 0.2 1.1 2.3 -0.7 0.5 1.2 1.5
Leg predicted mass (right) 0.2 1.1 1.3 -0.8 1.1 1.1 1.1
Arm fat mass (left) 0.8 3.4 9.4 -1.3 3.1 -0.9 -1.3
Number of self-reported non-cancer illnesses 0.7 1.2 2.0 -1.3 1.4 -0.9 0.3
Average weekly champagne plus white wine intake 0.6 0.8 1.3 -1.1 -0.0 -1.0 1.0
Miserableness 0.7 1.1 2.3 -1.5 -0.6 -0.9 -1.0
Guilty feelings 0.8 1.2 1.9 -1.4 -0.4 -1.1 -1.3
Wears glasses or contact lenses 2.4 2.7 9.0 -0.9 -3.0 0.7 0.7
Ever taken oral contraceptive pill 1.0 1.1 4.0 0.5 0.2 2.0 0.6
Hearing aid user 1.1 1.2 2.9 1.7 0.8 1.2 0.2
Mother’s age at death 1.7 2.1 3.0 1.1 -1.4 -1.7 -1.5
Financial situation satisfaction 0.2 0.3 0.8 -0.9 -0.3 0.3 0.5
Tinnitus: Yes, now most or all of the time 1.6 1.8 6.5 -0.0 -2.5 -0.9 0.4
Commuting to job workplace: Public transport 0.5 0.7 1.2 -0.3 -0.9 -0.7 1.1
Eye problems/disorders: Glaucoma 2.5 2.9 7.9 1.2 -0.1 1.5 2.8
Medication: Blood pressure 1.8 3.5 7.2 -2.6 2.7 -0.1 -0.0
Pain type(s) experienced in last month: Hip pain 1.1 1.4 3.7 -0.1 -1.9 -1.1 -0.8
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.3 0.5 -1.1 0.3 -0.3
High cholesterol (Self-reported) 2.4 4.2 7.9 1.5 1.4 2.1 2.8
Medication: Bendroflumethiazide 2.7 4.1 11.3 -1.1 3.4 1.1 1.6
Medication: Paracetamol 0.5 0.8 1.1 0.6 1.0 1.1 0.7
Medication: Lisinopril 1.9 2.4 5.7 0.0 2.4 0.8 1.8
Medication: Atorvastatin 2.1 2.6 5.5 2.3 0.5 1.7 1.3
Illnesses of father: High blood pressure 1.7 2.1 3.6 -0.5 1.4 -1.9 -1.7
Alcohol drinker status: Never 1.4 1.7 3.9 0.2 1.1 1.3 -2.0
Ever smoked 2.0 3.6 12.5 -0.8 -1.0 0.1 3.5
Basal metabolic rate 0.2 0.9 1.3 -0.7 1.0 0.8 1.1
Leg fat percentage (left) 1.0 3.7 9.7 0.1 3.1 -1.8 -1.4
Arm fat-free mass (left) 0.1 0.6 1.3 -0.6 0.2 0.8 1.1
Number of operations (self-reported) 0.7 1.0 1.8 -1.3 1.0 -0.3 1.0
Average weekly beer plus cider intake 1.2 1.8 3.6 1.9 0.8 1.4 -1.0
Irritability 0.3 0.6 1.0 0.9 -0.1 -1.0 -0.7
Risk taking 1.0 1.5 2.2 1.4 0.4 1.5 1.3
Ever had prostate specific antigen (PSA) test 0.4 0.4 1.6 -1.3 -0.2 0.1 0.1
Fractured/broken bones in last 5 years 0.6 0.8 1.9 1.4 -0.2 1.1 0.4
Age started oral contraceptive pill 0.3 0.4 0.5 -0.6 -0.6 -0.7 -0.7
Diastolic blood pressure, automated reading 0.6 1.7 3.2 -1.1 1.8 -0.8 -1.4
Ever depressed for a whole week 1.6 2.0 5.1 -2.2 0.6 -0.2 1.6
Unable to work because of sickness or disability 0.5 0.7 2.3 1.5 -0.1 0.5 -0.4
Commuting to job workplace: Cycle 0.5 0.6 1.1 0.9 0.7 0.1 1.0
Myopia 2.2 3.3 5.0 -2.2 -1.9 -1.9 -0.8
Vascular/heart problems diagnosed by doctor 1.1 3.0 8.2 1.9 -2.9 -0.1 -0.6
Cholesterol lowering medication 1.2 1.8 4.6 1.4 0.1 0.7 2.1
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 0.5 0.5 -0.7 -0.5 -0.2
Pain experienced in last month 0.3 0.5 1.3 1.1 0.8 0.0 0.4
Supplements: Calcium 0.2 0.3 0.4 0.6 -0.6 -0.3 -0.3
Basal cell carcinoma (self-reported) 3.5 4.1 7.7 1.0 2.6 1.1 2.8
Heart attack/myocardial infarction (self-reported) 1.8 2.3 6.1 2.5 -0.3 1.6 -0.8
Deep venous thrombosis (DVT) (self-reported) 1.2 1.5 3.7 -1.9 0.8 -1.3 0.2
Heart disease (siblings) 0.2 0.3 0.9 -0.0 -1.0 0.1 -0.3
Alcohol drinker status: Previous 0.1 0.1 0.2 -0.4 -0.1 0.2 0.3
Pack years of smoking 2.3 3.3 9.1 3.0 0.5 1.8 0.8
Impedance of whole body 0.4 2.2 3.6 -1.9 -1.3 -1.9 -0.5
Leg fat mass (left) 0.7 2.9 7.3 -0.4 2.7 -1.5 -1.3
Arm predicted mass (left) 0.2 0.8 2.0 -0.5 0.3 0.9 1.4