Hub : Genes

VAMP2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.2022	0.0343	0.0e+00	0.172	0.194	0.196	0.203	0.192	1.3e-21	2.6e-24	1.3e-24	1.7e-25	4.5e-24
2	TCGA	Breast Invasive Carcinoma	0.0357	0.0163	2.7e-05	0.014	0.022	0.016	NA	0.014	5.5e-04	2.0e-05	2.1e-04	NA	6.6e-04
3	TCGA	Colon Adenocarcinoma	0.0570	0.0350	3.3e-03	-0.003	0.021	-0.004	NA	-0.002	5.9e-01	2.1e-02	6.1e-01	NA	4.7e-01
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0329	0.0192	4.8e-03	0.023	0.011	0.024	NA	0.020	1.2e-03	1.7e-02	8.0e-04	NA	2.5e-03
5	TCGA	Brain Lower Grade Glioma	0.0292	0.0163	3.1e-03	0.017	0.009	0.003	NA	0.005	3.9e-03	2.9e-02	1.5e-01	NA	8.9e-02
6	TCGA	Pheochromocytoma and Paraganglioma	0.1630	0.0910	2.6e-03	0.015	0.016	0.028	NA	0.006	8.0e-02	7.3e-02	2.8e-02	NA	1.8e-01
7	TCGA	Prostate Adenocarcinoma	0.0626	0.0328	2.5e-04	0.048	0.039	0.021	NA	0.042	9.0e-06	5.1e-05	2.6e-03	NA	3.1e-05
8	TCGA	Rectum Adenocarcinoma	0.2470	0.1050	4.1e-03	-0.011	0.025	0.004	NA	-0.012	7.3e-01	8.7e-02	2.6e-01	NA	8.3e-01
9	TCGA	Thyroid Carcinoma	0.0710	0.0300	1.9e-05	0.051	0.050	0.049	NA	0.049	1.0e-05	1.1e-05	1.3e-05	NA	1.5e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Bipolar Disorder (2018)	1.2	1.8	2.5	1.3	1.6	-1.5	1.2	1.4	1.2	1.5	0.7	1.6
Bipolar Disorder or Schizophrenia	0.3	0.8	2.2	1.1	1.0	0.7	1.5	0.5	-0.5	0.4	1.5	0.4
Depressed Affect (Nagel 2018)	1.5	3.1	6.5	1.7	2.5	-1.4	1.9	1.7	2.0	2.2	-0.7	0.7
Depression (Nagel 2018)	0.9	1.4	5.4	1.3	2.3	0.8	1.7	0.2	0.2	0.6	-0.9	-0.5
Intelligence (Savage-Jansen 2018)	3.9	12.0	26.5	-4.2	-5.1	1.7	-4.0	-3.5	-2.4	-3.4	-1.1	-3.7
Neuroticism (Nagel 2018)	2.5	6.0	12.6	2.7	3.4	-1.6	3.5	2.5	2.2	2.8	0.5	1.0
Schizophrenia (2018)	0.5	1.0	3.6	0.4	0.1	1.9	0.9	-0.4	-1.3	-0.7	1.3	-0.9
Schizophrenia vs Biploar Disorder	0.6	0.8	1.6	0.0	1.2	1.2	-0.1	-0.6	0.3	-0.7	-1.3	-1.1
Worry (Nagel 2018)	4.7	9.9	22.1	3.4	3.6	-2.1	4.7	3.5	2.1	3.6	2.0	2.1
Alzheimer’s Disease (in mother)	0.2	0.3	1.0	0.6	0.6	1.0	-0.4	-0.1	-0.1	-0.3	0.3	0.6
Alzheimer’s Disease (in father)	0.2	0.2	0.9	0.1	0.2	0.1	0.9	0.1	0.5	-0.2	0.8	-0.6
Alzheimer’s Disease (including proxy)	0.4	0.5	1.3	1.0	0.7	0.5	0.7	0.5	0.7	0.4	1.1	0.3
Crohns Disease (2017)	0.0	0.1	0.3	0.3	0.6	-0.1	-0.0	0.2	-0.0	-0.1	-0.4	0.3
Irritable Bowel Disease (IBD)	0.1	0.2	0.5	0.7	0.7	-0.2	0.5	0.5	0.3	0.2	-0.0	0.3
Ulcerative Colitis (UC)	0.4	0.7	1.2	1.1	0.8	-0.5	1.1	0.9	0.9	0.9	0.6	0.5
Major Depression (MDD)	3.2	3.9	6.9	1.9	1.8	-1.9	2.0	2.2	2.2	2.6	0.8	1.6
Reaction Time	0.5	1.0	2.9	0.7	1.4	0.0	0.5	0.2	1.7	1.2	-1.4	-0.5
Verbal and Numeric Reasoning (VNR)	5.2	12.4	29.1	-4.6	-5.4	1.2	-4.1	-3.3	-3.5	-3.5	-1.0	-2.7
Breast Cancer	2.8	6.6	10.6	-2.5	-2.1	2.7	-1.6	-3.1	-2.6	-2.8	-2.0	-3.2
Ovarian Cancer	0.7	0.9	2.6	-1.6	-1.5	0.5	-0.7	-0.9	-0.8	-0.9	-0.1	-0.9
Prostate Cancer	2.5	3.5	5.4	-1.6	-0.5	1.9	-1.7	-2.2	-2.3	-2.2	-2.0	-1.9
Age at First Birth	0.3	0.5	1.5	-0.3	-0.7	1.2	-0.9	-0.7	-0.3	-0.5	0.7	-0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.2	0.3	0.7	0.3	0.6	-0.3	0.8	0.7	-0.0	0.7	0.3	0.2
Coronary Artery Disease (CAD)	0.1	0.2	0.5	-0.1	0.7	-0.2	0.4	-0.0	-0.7	-0.3	-0.4	0.2
Crohns Disease (2012)	0.2	0.3	0.6	-0.6	-0.3	0.2	-0.4	-0.5	-0.8	-0.6	-0.6	-0.3
Mean Putamen Volume	0.5	0.6	2.4	0.7	0.6	-0.6	0.7	0.5	1.5	0.7	-0.2	-0.4
Fasting Glucose	2.1	2.5	4.8	0.8	0.7	-2.2	1.5	2.0	1.9	2.2	0.8	1.2
HbA1C	0.2	0.2	0.5	-0.7	-0.2	0.2	-0.5	-0.5	-0.5	-0.7	-0.4	-0.2
HDL Cholesterol	4.2	7.0	9.5	-2.7	-2.5	2.2	-2.7	-3.0	-3.0	-3.1	-1.9	-2.4
LDL Cholesterol	5.8	9.2	13.8	-3.2	-2.6	2.4	-3.6	-3.5	-3.6	-3.7	-2.0	-2.0
Lupus	0.2	0.3	0.9	0.6	0.9	0.8	-0.2	-0.3	0.0	-0.1	-0.5	0.0
Neuroticism (2016)	1.3	1.8	3.3	1.8	1.6	-1.0	1.2	1.4	1.7	1.4	0.7	0.8
Primary Biliary Cirrhosis	0.3	0.5	1.6	0.7	0.9	-0.8	0.4	0.6	0.2	0.4	0.0	1.3
Rheumatoid Arthritis	0.7	1.0	1.7	-0.9	-0.6	1.3	-0.8	-1.3	-1.0	-1.0	-0.7	-1.0
Schizophrenia (2014)	0.4	1.0	3.1	1.0	0.9	0.8	1.8	0.6	-0.5	0.3	1.6	0.0
Triglycerides	1.4	2.2	3.2	1.5	1.1	-1.2	1.7	1.8	1.1	1.8	1.5	1.6
Type 2 Diabetes (T2D) (2012)	1.4	1.6	5.8	1.6	2.4	-0.5	0.5	0.6	1.5	0.8	-1.1	0.9
Ulcerative Colitis	1.0	1.4	2.1	1.3	1.0	-1.2	1.1	1.3	1.2	1.2	0.8	1.5
Blood Eosinophil Count	0.1	1.1	5.2	-0.3	-2.3	-1.8	-0.7	0.5	0.3	0.8	0.5	-0.1
Blood Platelet Count	0.4	4.1	9.2	3.0	2.4	-0.7	2.4	1.8	1.2	1.9	1.6	2.1
Blood Red Count	2.3	22.1	52.9	-2.1	0.7	7.3	-3.1	-5.8	-5.6	-5.5	-4.1	-4.4
Blood White Count	1.6	11.8	31.2	5.6	4.9	-1.3	2.9	2.8	4.7	3.1	-0.5	1.1
Heel T-Score	0.3	2.7	7.9	-2.8	-1.2	1.9	-1.4	-2.0	-1.6	-0.7	-1.5	-0.7
BMI	0.6	3.8	13.4	3.1	3.7	0.5	1.1	0.8	2.5	1.2	-1.0	-0.5
Height	1.3	24.7	98.0	-7.1	-9.9	-6.6	-4.5	0.6	-1.6	-0.9	2.1	1.2
Waist Hip Ratio (WHR)	0.7	3.1	5.2	-2.3	-1.4	1.0	-1.6	-2.2	-1.6	-2.0	-1.5	-1.9
Systolic Blood Pressure	3.0	15.2	37.7	6.1	4.9	-0.5	4.4	3.8	2.6	3.1	3.9	2.9
Smoking Status	2.4	5.8	16.6	2.8	4.1	-0.4	2.9	1.9	2.9	2.6	0.2	0.9
Allergy or Eczema	0.4	0.9	4.0	0.8	1.0	2.0	-0.4	-0.9	-0.2	-0.7	-0.8	-0.8
Cardiovascular Disease	1.9	6.4	14.5	3.8	3.6	-0.5	3.1	2.3	0.9	1.9	2.3	2.2
Hypothyroidism (self reported)	1.9	4.4	9.0	2.8	2.7	-1.6	1.8	1.8	3.0	2.3	-0.9	0.5
Respiratory disease	0.3	0.7	2.3	-0.4	0.7	1.0	-0.1	-0.9	-0.3	-0.6	-1.5	-1.1
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.1	0.5	0.8	-1.5	-0.0	0.9	1.4	0.8	-0.1	0.7
Lung FEV1/FVC ratio	0.1	0.4	1.1	0.5	-0.1	-0.1	0.5	0.5	1.0	0.8	0.3	-0.9
Lung FVC	0.3	1.5	4.2	0.8	1.2	2.0	1.2	-0.4	-1.8	0.2	0.6	1.3
Neuroticism	5.4	13.0	23.4	3.5	4.1	-3.3	4.8	4.1	2.9	4.6	1.3	2.5
Chronotype (morning person)	3.2	7.3	22.8	1.3	-0.4	4.8	-0.7	-3.0	0.2	-2.9	-0.7	-4.8
Hair Pigment	0.1	1.5	4.2	0.2	0.7	2.0	-0.3	-1.3	-1.6	-1.5	-0.8	-1.3
Tanning	0.1	1.5	4.1	1.9	0.1	0.5	0.8	0.5	2.0	0.6	1.9	-1.0
Hand grip strength (left)	0.7	1.8	4.3	-1.9	-2.1	0.5	-1.2	-1.1	-0.5	-1.5	0.1	-1.6
Number of treatments/medications taken	2.9	5.3	17.6	3.5	4.2	-0.1	2.7	1.9	1.6	1.3	0.7	1.2
Average weekly spirits intake	0.2	0.2	0.9	0.7	0.2	0.1	0.5	0.1	0.2	0.2	1.0	0.0
Sensitivity / hurt feelings	1.6	2.8	6.5	2.3	2.6	-0.5	2.5	1.3	1.6	1.6	0.6	0.4
Frequency of depressed mood in last 2 weeks	1.4	1.9	7.5	1.9	2.7	0.4	1.9	0.5	0.9	0.8	-0.8	-0.3
Hearing difficulty/problems: Yes	1.1	1.6	4.0	2.0	1.8	-1.2	1.0	1.2	0.9	0.9	-0.6	1.2
Relative age of first facial hair	1.6	3.3	8.3	-2.3	-1.5	0.2	-2.9	-1.6	-1.2	-1.5	-2.6	-0.6
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	4.3	1.3	2.1	-0.5	0.6	0.5	1.0	1.0	-1.6	0.3
Ever used hormone-replacement therapy (HRT)	0.8	1.1	3.2	1.8	1.2	0.2	1.3	1.0	0.8	0.3	1.2	0.3
Ever had hysterectomy (womb removed)	0.5	0.6	3.3	0.5	-1.0	0.0	0.2	0.3	-0.3	-0.4	1.8	0.2
Systolic blood pressure, automated reading	1.4	4.0	8.5	2.9	2.1	-0.7	2.0	2.3	1.1	2.0	2.1	1.9
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	2.3	0.3	0.5	-1.5	0.5	0.9	0.6	0.4	0.3	1.0
Angina	0.1	0.1	0.5	0.7	0.1	0.5	-0.2	-0.1	0.1	-0.3	0.2	-0.4
Medication for hormone replacement therapy	0.1	0.1	0.3	0.5	0.2	0.5	0.3	0.0	-0.1	-0.2	0.5	-0.5
Vitamin and mineral supplements	0.4	0.6	2.0	0.1	1.1	0.2	-0.6	-0.5	0.1	0.3	-1.4	1.1
Supplements: Zinc	1.0	1.1	2.1	1.4	1.3	-0.1	0.9	1.0	1.1	0.8	1.1	1.0
Medication: Co-codamol	0.7	0.8	3.6	-0.6	0.1	0.6	-0.6	-0.9	-0.3	-0.6	-1.9	-1.1
Medication: Metformin	1.6	2.3	3.3	1.4	1.1	-1.6	1.5	1.8	1.6	1.3	1.8	1.3
Diabetes (father)	1.1	1.4	4.1	2.0	2.0	0.1	1.1	0.9	1.1	0.6	0.3	0.9
Diabetes (mother)	0.9	1.2	4.3	1.2	2.1	-0.8	1.0	1.1	0.5	0.8	0.0	1.1
Severe depression (siblings)	0.9	1.0	2.8	1.0	0.9	-0.8	0.9	1.1	0.1	0.9	0.8	1.7
Pack years adult smoking proportion	2.2	3.4	9.4	2.3	3.1	-1.4	1.3	1.2	2.8	1.1	-1.1	0.4
Impedance of leg (right)	0.5	2.5	6.0	-2.5	-1.9	0.2	-1.5	-1.4	-2.1	-1.6	-1.2	-0.4
Leg fat-free mass (left)	0.3	1.8	6.9	-0.0	-1.4	-2.6	-0.1	1.5	1.2	0.9	1.5	0.7
Trunk fat percentage	0.4	1.5	3.1	-0.6	-0.1	1.4	-1.4	-1.5	-0.2	-1.2	-1.7	-1.8
Hand grip strength (right)	0.8	2.0	6.2	-2.5	-2.2	-0.1	-1.0	-1.2	-0.5	-1.3	-0.3	-1.7
Townsend deprivation index at recruitment	1.3	1.8	6.2	2.1	2.5	-0.6	0.8	1.0	1.3	0.7	-0.2	1.1
Current tobacco smoking	0.6	1.0	2.9	0.8	1.7	0.0	0.3	0.1	1.3	0.3	-1.7	-0.6
Average weekly fortified wine intake	0.1	0.1	0.7	0.1	-0.3	-0.4	0.3	0.4	0.2	0.0	0.9	-0.1
Maternal smoking around birth	0.8	1.2	5.1	0.5	2.3	0.1	0.7	0.4	0.6	1.2	-1.2	1.0
Fed-up feelings	1.9	3.5	7.4	1.2	2.7	-2.0	1.3	1.6	2.4	2.4	-1.6	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.7	5.8	1.2	2.4	0.9	1.2	-0.5	-0.5	-0.0	-2.1	-0.8
Relative age voice broke	0.4	0.6	1.3	-1.0	-0.6	-0.3	-1.0	-0.5	-1.0	-0.7	-1.1	0.2
Taking other prescription medications	2.8	4.4	15.8	3.3	4.0	-0.5	1.9	1.5	1.7	1.4	-0.9	1.0
Age when periods started (menarche)	0.5	1.2	2.2	-0.9	-0.8	0.5	-1.1	-1.3	-1.2	-1.5	-1.3	-0.9
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.4	0.8	-0.8	0.3	-0.4	0.2	0.4	-0.4	1.2	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.8	-0.8	-0.1	0.9	-0.7	-0.8	-0.5	-0.1	-0.7	-0.2
Tinnitus: Yes, but not now, but have in the past	2.4	2.6	8.0	2.0	2.8	-0.0	2.2	1.4	1.4	1.2	1.1	0.7
Qualifications: CSEs or equivalent	1.3	1.8	7.2	2.1	2.7	0.8	1.3	0.4	0.6	0.2	0.3	1.1
Serious illness, injury or assault to yourself	0.8	1.0	2.1	0.9	1.4	-1.4	0.7	1.3	1.0	0.7	-0.6	0.6
High blood pressure	2.8	7.9	15.8	4.0	2.5	-1.4	2.9	3.1	1.6	2.6	3.4	2.8
Hayfever, allergic rhinitis or eczema	0.4	0.8	3.2	0.7	0.4	1.8	-0.6	-1.0	-0.1	-0.8	-0.8	-1.1
Multivitamins +/- minerals	0.7	0.9	4.4	0.6	-0.8	-0.6	0.9	0.9	0.5	0.4	2.1	-0.2
Stomach or abdominal pain in last month	0.4	0.5	2.3	0.3	0.6	-0.3	-0.8	0.0	1.5	0.2	-1.1	-0.1
Supplements: Glucosamine	1.5	1.9	5.0	1.2	0.7	-1.2	1.8	1.9	0.9	1.0	2.2	0.6
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.6	-0.1	-0.5	-0.8	-0.3	0.3	-0.3	0.1	-0.0	0.6
Medication: Atenolol	2.1	2.6	5.0	1.6	1.0	-0.9	2.2	1.8	0.7	1.6	2.2	1.8
Medication: Levothyroxine sodium	0.8	1.4	3.2	1.6	1.8	-0.9	0.7	1.0	1.5	1.1	-0.8	0.5
Sitting height	1.0	7.0	23.7	-1.8	-4.1	-4.9	-1.2	2.0	0.9	1.2	2.1	2.7
Chronic bronchitis/emphysema (father)	0.2	0.2	0.5	-0.5	0.0	0.6	-0.7	-0.4	-0.2	-0.3	-0.3	-0.3
High blood pressure (mother)	2.2	3.1	4.7	1.9	0.9	-1.6	1.8	2.1	1.0	2.2	2.0	1.8
Body mass index (BMI)	0.4	1.5	5.4	2.0	2.3	0.2	0.8	0.5	1.4	0.9	-0.5	-0.1
Impedance of leg (left)	0.5	2.4	5.4	-2.3	-1.8	0.4	-1.3	-1.5	-2.3	-1.6	-1.1	-0.4
Leg predicted mass (left)	0.4	1.9	7.6	-0.0	-1.4	-2.8	-0.1	1.5	1.3	0.9	1.5	0.7
Trunk fat mass	0.1	0.5	1.3	-0.5	-0.7	0.0	-1.2	-0.7	0.2	-0.7	-0.7	-1.2
Waist circumference	0.2	0.8	2.2	1.2	1.5	-0.8	0.3	0.7	1.4	0.7	-0.2	0.2
Number of incorrect matches in round	7.5	12.4	19.3	3.3	4.1	-2.6	4.4	3.9	3.0	4.2	2.2	3.4
Past tobacco smoking	7.0	12.8	22.6	-4.3	-4.7	1.2	-4.2	-3.5	-3.5	-4.2	-2.5	-2.6
Alcohol usually taken with meals	1.4	2.2	9.4	0.8	0.2	-0.7	1.8	1.6	0.7	1.1	3.1	1.3
Nervous feelings	3.8	7.1	12.4	3.0	3.4	-1.9	3.5	3.0	1.9	3.2	0.8	2.1
Frequency of tenseness / restlessness in last 2 weeks	3.3	5.1	12.6	2.9	3.5	-1.2	2.9	2.2	2.1	2.2	0.5	1.0
Hearing difficulty/problems with background noise	0.6	1.0	3.4	1.9	1.1	-0.0	1.1	0.8	0.2	0.0	1.2	0.7
Hair/balding pattern: Pattern 2	1.8	2.2	5.0	2.2	1.4	-0.6	1.4	1.5	1.2	1.7	1.1	1.8
Had menopause	0.9	1.1	2.7	-0.1	-0.4	-1.4	0.6	1.2	0.1	1.0	1.5	1.6
Had other major operations	0.3	0.3	1.1	-0.1	0.6	-0.8	-0.0	0.1	0.6	-0.3	-1.1	-0.5
Forced vital capacity (FVC)	0.2	0.9	3.3	-1.5	-1.8	-0.6	-0.4	-0.1	-0.9	-0.2	0.9	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.1	0.5	-0.4	-0.2	0.7	-0.5	-0.4	-0.2	-0.1	0.1	0.1
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	3.1	0.6	1.0	-0.3	1.7	0.9	-0.9	0.9	0.7	1.8
Qualifications: None of the above	0.8	1.8	7.0	2.2	2.6	0.5	1.4	0.8	0.3	0.8	0.3	0.9
Financial difficulties in last 2 years	2.2	3.0	8.8	2.8	3.0	-0.0	1.9	1.0	2.0	0.9	0.1	0.3
Mouth/teeth dental problems	1.2	1.8	5.5	-1.8	-2.3	-0.2	-1.5	-0.8	-0.2	-1.6	-0.1	-1.3
Heart attack	0.7	0.9	2.2	-0.4	0.1	1.5	-0.8	-1.1	-0.9	-1.0	-0.9	-0.9
Allergy	0.4	1.0	2.4	-0.3	-0.3	-1.5	0.8	1.1	0.3	1.0	1.3	1.4
Pain all over the body in last month	1.7	1.8	5.9	1.4	2.4	-0.8	1.1	1.3	0.3	1.0	-0.2	2.0
Diabetes (self-reported)	0.9	1.4	2.9	1.1	1.7	-1.4	0.6	1.3	1.5	1.2	0.2	1.2
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	2.5	-0.2	-1.0	1.6	-0.8	-1.2	-0.2	-1.4	0.2	-1.2
Medication: Ramipril	0.3	0.4	1.1	1.0	0.6	1.0	0.2	0.2	0.4	0.0	1.0	0.0
Medication: Simvastatin	0.4	0.6	1.4	0.4	0.7	1.2	0.4	-0.1	-0.9	-1.1	0.9	-0.1
Fluid intelligence score	4.5	9.4	17.5	-3.3	-4.2	1.5	-3.9	-3.2	-2.4	-3.4	-1.5	-3.1
Illnesses of siblings	1.0	1.4	5.1	-2.3	-1.6	-0.3	-0.7	-0.9	-0.7	-0.5	-1.2	-1.1
Neuroticism score	3.2	6.6	11.9	2.5	2.9	-2.7	3.5	2.9	2.1	3.3	0.3	1.6
Weight	0.2	0.8	3.7	-0.1	-1.0	-1.9	-0.5	0.8	0.8	0.4	0.7	0.4
Impedance of arm (right)	1.7	7.9	13.0	-3.6	-3.5	2.1	-2.9	-3.0	-1.8	-2.8	-1.7	-3.2
Arm fat percentage (right)	0.2	0.9	3.1	0.2	0.5	1.1	-0.6	-0.9	0.7	-0.4	-1.4	-1.8
Trunk fat-free mass	1.2	7.1	25.6	0.3	-1.6	-5.1	0.8	3.3	1.5	2.2	3.1	2.8
Hip circumference	0.5	2.0	4.2	1.7	1.4	-1.5	1.0	1.7	2.0	1.4	0.7	0.7
Time employed in main current job	0.7	0.8	2.6	-0.8	-1.1	0.6	-1.0	-0.6	-1.6	-1.0	0.5	0.2
Alcohol intake versus 10 years previously	0.5	0.8	1.9	1.1	1.4	-0.8	0.6	0.7	1.0	0.9	-0.5	0.9
Father’s age at death	0.4	0.5	1.4	-1.2	-1.1	-0.9	-0.3	-0.0	0.5	0.2	-0.6	-0.8
Worrier / anxious feelings	2.6	4.9	9.8	2.4	2.1	-1.7	3.1	2.6	1.9	2.8	1.2	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	5.0	1.4	2.2	0.7	1.0	0.0	0.3	0.1	-1.1	-0.6
Falls in the last year	4.7	6.3	10.1	2.8	2.5	-1.7	3.2	2.8	0.9	2.5	2.8	2.7
Hair/balding pattern: Pattern 3	0.1	0.2	0.7	0.3	0.8	-0.1	0.1	0.0	0.1	0.1	-0.8	-0.1
Number of live births	9.6	13.6	21.8	4.5	4.7	-2.5	4.3	3.8	3.0	4.2	1.7	3.5
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	1.9	-0.9	-1.4	-0.9	-0.0	0.3	-0.0	0.5	0.8	0.6
Pulse rate	0.6	1.1	3.1	-0.2	-1.1	-1.5	0.6	0.9	-0.4	0.8	1.8	1.0
Happiness	0.5	0.6	1.2	0.2	-0.1	-1.1	0.9	1.0	0.8	1.0	1.0	0.5
Noisy workplace	3.5	4.3	12.5	3.2	3.5	-0.4	2.0	1.7	1.4	2.1	0.3	1.7
Qualifications: A levels/AS levels or equivalent	2.5	5.6	16.8	-3.4	-4.1	-0.1	-2.6	-2.0	-1.5	-2.1	-1.0	-1.7
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	1.0	-0.1	-1.0	-0.9	-0.3	0.3	0.1	-0.1	0.3	0.0
Mouth/teeth dental problems: Dentures	1.4	2.4	9.3	2.2	3.0	0.1	1.3	0.8	1.5	1.5	-0.8	0.5
Asthma	0.4	0.7	1.3	-0.7	-0.4	1.1	-0.7	-1.1	-0.7	-0.9	-0.8	-0.9
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.6	2.5	1.6	1.5	-0.5	1.3	1.3	1.2	1.2	0.9	1.3
Medication: Cholesterol lowering	0.4	0.7	2.3	-0.3	0.0	1.2	0.0	-0.3	-1.5	-0.9	1.1	-0.2
Depression (self-reported)	3.0	3.6	10.9	0.8	2.2	2.4	-0.8	-1.6	1.1	-0.8	-3.3	-2.2
Medication: Lansoprazole	1.5	1.7	9.1	0.9	3.0	0.1	1.1	0.5	-0.4	0.6	-1.1	1.5
Prospective memory result	2.5	3.1	6.8	1.8	2.6	-1.1	2.3	1.7	0.5	1.8	0.2	2.3
Lung cancer (father)	0.7	0.8	3.2	-0.1	0.3	-0.3	-0.8	-0.3	1.6	-0.0	-1.8	-0.8
Illnesses of mother	1.4	1.7	5.5	-1.8	-2.3	-0.1	-1.2	-0.9	-0.6	-1.1	-0.2	-1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	2.8	-0.1	-0.8	-1.5	0.3	1.0	0.5	1.3	1.1	1.7
Pulse wave Arterial Stiffness index	1.1	1.3	2.8	1.5	1.7	-1.0	0.9	1.0	1.0	1.1	0.1	1.4
Impedance of arm (left)	2.6	12.2	16.0	-4.0	-3.8	3.2	-3.4	-4.0	-2.7	-3.8	-2.2	-3.9
Arm fat mass (right)	0.1	0.3	0.8	0.1	0.0	-0.2	-0.6	-0.2	0.9	-0.0	-0.6	-0.8
Trunk predicted mass	1.2	6.7	24.9	0.1	-1.7	-5.0	0.7	3.1	1.4	2.0	2.9	2.6
Standing height	1.2	11.5	46.5	-4.1	-6.8	-4.8	-2.5	0.9	-1.2	-0.8	2.7	1.1
Length of working week for main job	0.1	0.1	0.4	-0.2	-0.2	-0.0	0.2	-0.3	-0.1	-0.6	-0.1	-0.4
Exposure to tobacco smoke at home	0.3	0.4	1.7	0.8	1.3	0.2	0.0	-0.1	0.9	0.1	-0.4	-0.2
Breastfed as a baby	0.2	0.3	0.8	0.9	-0.6	0.2	-0.5	-0.1	0.0	-0.8	0.5	0.2
Tense / ‘highly strung’	7.8	12.9	20.3	4.4	4.1	-2.8	4.5	3.9	3.2	4.1	1.7	2.8
Seen doctor (GP) for nerves, anxiety, tension or depression	2.2	3.4	6.5	1.3	2.5	-1.9	2.4	2.1	1.0	2.0	0.3	1.9
Hair/balding pattern: Pattern 4	0.3	0.7	3.5	1.0	-0.8	0.5	-0.2	0.2	0.8	-0.1	1.9	-0.3
Birth weight of first child	1.4	2.5	6.0	0.8	-0.1	-2.4	0.9	1.9	0.9	1.6	1.8	2.3
Peak expiratory flow (PEF)	0.1	0.3	0.9	-0.4	-0.7	1.0	-0.4	-0.5	0.4	-0.3	0.2	-0.7
Pulse wave reflection index	0.3	0.3	1.1	0.2	0.6	0.5	-0.7	-0.6	-0.2	-0.4	-1.1	0.5
Ever highly irritable/argumentative for 2 days	3.2	3.8	8.7	2.1	2.9	-0.3	2.8	1.7	0.4	1.9	1.3	2.2
Loud music exposure frequency	0.5	0.5	2.7	0.5	-0.7	-0.3	0.4	0.4	-0.6	-0.5	1.6	0.5
Qualifications: O levels/GCSEs or equivalent	2.4	3.7	10.5	-2.8	-3.2	0.5	-2.2	-1.6	-1.3	-2.0	-0.3	-1.4
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	2.8	1.4	-0.0	1.7	-0.3	-0.5	-0.0	-0.2	0.6	-0.2
Blood clot in the leg (DVT)	1.7	2.2	4.2	2.0	1.1	-1.3	1.5	1.8	1.7	1.2	1.5	0.6
Medication: Paracetamol	5.0	8.3	12.3	3.4	3.2	-1.3	3.5	2.9	2.9	3.2	2.6	2.0
Headache pain in last month	0.6	1.0	2.5	0.6	1.2	-0.7	1.0	0.8	1.5	1.6	0.1	0.8
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	3.0	-0.2	-0.1	-0.9	-0.5	0.1	1.7	0.6	-1.3	-0.2
Glaucoma (self-reported)	0.9	1.0	2.0	1.2	0.4	-1.4	0.7	1.4	0.7	0.9	1.1	0.8
Gout (self-reported)	0.0	0.0	0.1	0.2	0.1	-0.1	-0.1	-0.0	-0.2	0.0	-0.2	0.4
Hypothyroidism/myxoedema (self-reported)	1.5	3.0	6.7	2.3	2.6	-1.1	1.5	1.5	2.1	1.8	-0.6	0.8
Medication: Amlodipine	0.3	0.5	1.5	1.2	1.1	0.6	0.6	0.3	0.6	0.2	0.4	0.1
Medication: Ventolin 100micrograms inhaler	1.0	1.3	3.0	-0.6	-0.7	1.5	-0.7	-1.3	-1.0	-1.3	-0.7	-1.7
Birth weight	1.3	2.8	4.7	1.4	0.7	-2.2	1.5	2.0	1.7	2.2	1.2	1.6
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.7	0.7	1.3	0.9	-0.1	-0.2	0.5	-0.2	-0.6	0.1
High blood pressure (siblings)	1.3	1.9	4.4	2.1	1.8	0.1	1.4	1.2	0.1	1.1	1.7	1.5
Forced vital capacity (FVC), Best measure	0.2	0.9	2.6	-0.9	-1.6	-0.9	-0.2	0.2	-0.7	0.2	1.1	1.3
Body fat percentage	0.3	1.0	2.4	-0.1	0.4	1.2	-0.9	-1.1	0.1	-0.8	-1.5	-1.5
Leg fat percentage (right)	0.1	0.3	1.3	0.7	1.1	0.1	0.0	-0.1	0.3	0.1	-1.0	-0.3
Arm fat-free mass (right)	0.7	3.5	13.2	0.5	-0.9	-3.6	0.5	2.3	1.0	1.4	2.1	2.1
Exposure to tobacco smoke outside home	5.8	7.7	13.5	-1.8	-0.8	3.5	-3.7	-3.6	-1.7	-3.1	-3.0	-2.2
Comparative body size at age 10	0.5	1.3	4.2	-1.4	-1.5	0.6	-0.9	-0.9	-0.2	-1.0	0.2	-2.1
Number of full brothers	1.7	2.1	4.8	2.2	1.9	-0.2	1.9	1.6	0.0	0.6	1.6	1.4
Worry too long after embarrassment	3.0	5.0	9.3	1.6	1.6	-3.0	3.1	2.8	1.6	2.8	1.1	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	3.6	0.0	1.9	-0.9	0.7	0.8	0.2	1.1	-1.4	1.3
Wheeze or whistling in the chest in last year	1.1	2.0	4.5	-1.1	-0.9	1.0	-1.7	-1.6	-0.3	-1.3	-2.1	-1.8
Number of children fathered	0.2	0.2	0.6	0.2	0.5	0.0	0.1	0.0	0.6	0.8	-0.4	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.7	0.2	0.2	-0.6	0.5	0.6	-0.2	0.7	0.6	0.8
Age at first live birth	2.2	3.9	9.8	-3.1	-2.7	0.8	-2.2	-2.2	-1.5	-1.7	-0.9	-1.5
Pulse wave peak to peak time	1.1	1.3	4.2	-1.6	-2.0	0.5	-0.8	-0.8	-0.9	-1.0	0.3	-1.2
Health satisfaction	3.6	4.6	16.6	2.5	4.1	-0.5	2.4	1.7	2.1	1.9	-0.4	1.2
Shortness of breath walking on level ground	1.4	1.6	3.0	-0.8	-0.1	1.4	-1.3	-1.6	-1.0	-1.4	-1.7	-1.3
Qualifications: College or University degree	1.2	3.7	17.7	-2.1	-4.2	-0.9	-1.9	-0.8	-0.3	-1.5	0.8	-1.9
Eye problems/disorders: None of the above	0.2	0.3	0.7	-0.3	-0.5	0.9	-0.3	-0.7	-0.1	-0.3	-0.3	-0.7
Mouth/teeth dental problems: Loose teeth	0.9	1.1	6.7	-1.0	0.7	0.0	-1.0	-0.8	0.4	0.1	-2.6	-0.4
Emphysema/chronic bronchitis	0.7	0.8	1.7	-0.3	0.5	1.1	-0.2	-0.8	-0.4	-1.1	-1.3	-1.3
Medication for pain relief, constipation, heartburn	5.0	8.5	15.9	-3.8	-4.0	1.2	-3.2	-2.8	-3.3	-3.0	-1.7	-1.9
Neck or shoulder pain in last month	0.9	1.3	2.9	1.7	1.0	-0.4	1.4	1.1	0.4	0.6	1.4	1.4
Medication: Blood pressure	0.4	0.6	1.8	0.8	0.3	1.2	0.5	-0.2	-1.4	-0.8	0.9	-0.1
Angina (self-reported)	0.1	0.1	0.3	0.6	-0.0	0.5	-0.3	-0.2	-0.1	-0.5	0.1	-0.5
Migraine (self-reported)	1.1	1.3	3.4	0.3	1.5	-0.9	1.9	1.0	0.3	1.6	0.2	1.4
Medication: Ibuprofen	1.1	1.3	1.9	0.9	0.6	-1.1	1.2	1.4	1.1	1.3	1.3	1.3
Medication: Allopurinol	0.4	0.5	1.2	-0.4	-0.6	0.5	-0.8	-0.8	-1.1	-0.8	-0.8	-0.2
Medication: Omeprazole	2.4	2.9	7.1	2.7	2.3	-1.0	1.8	1.7	1.6	1.3	0.6	1.2
Medication: Seretide 50 evohaler	0.3	0.4	1.1	-0.4	0.4	0.7	-1.0	-0.6	-0.3	-0.3	-0.7	0.5
Mean time to correctly identify matches	0.6	1.1	3.4	0.8	1.0	-0.7	0.8	1.1	1.1	1.8	0.2	0.9
Heart disease (mother)	0.9	1.1	5.9	0.2	1.0	0.1	-0.8	-0.7	1.1	-0.4	-2.4	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.5	2.9	6.0	2.5	1.8	-1.1	1.9	1.7	2.2	1.7	0.7	1.0
Whole body fat mass	0.0	0.2	0.6	-0.1	-0.3	-0.3	-0.7	-0.2	0.5	-0.3	-0.4	-0.8
Leg fat mass (right)	0.1	0.4	0.9	0.8	0.5	-0.9	0.1	0.6	0.9	0.6	0.0	0.1
Arm predicted mass (right)	0.7	3.3	13.2	0.3	-1.1	-3.6	0.4	2.2	0.8	1.2	2.1	2.0
Pulse rate, automated reading	0.3	1.0	3.2	-1.4	-1.8	-0.6	-0.9	-0.8	-1.0	-0.6	0.3	-0.6
Alcohol intake frequency.	1.2	2.7	7.3	2.6	2.7	-0.6	0.6	1.2	2.0	1.6	-1.1	0.6
Comparative height size at age 10	1.0	5.8	15.8	-0.7	-4.0	-3.9	-0.5	2.1	1.0	0.9	3.5	1.4
Number of full sisters	7.9	9.6	17.5	4.2	3.7	-1.9	3.5	3.3	2.9	2.9	2.1	2.6
Suffer from ‘nerves’	1.5	2.3	5.9	1.1	1.8	-1.5	2.4	1.8	0.6	1.9	0.1	1.0
Overall health rating	3.4	7.3	21.0	3.8	4.6	-1.1	2.1	2.2	3.2	2.5	-0.7	1.7
Chest pain or discomfort	1.6	2.2	7.6	-1.1	-0.6	0.5	-1.6	-1.7	-0.7	-1.4	-2.8	-1.8
Had major operations	0.4	0.5	1.8	-0.4	-0.7	0.3	-1.3	-0.8	-0.4	-0.7	-0.7	-0.5
Age at last live birth	0.4	0.5	2.5	-1.6	-0.7	-0.5	-0.7	-0.6	-0.2	-0.1	-0.7	-0.3
Family relationship satisfaction	0.1	0.1	0.3	0.2	-0.1	-0.3	0.3	0.4	0.3	0.1	0.6	0.0
Leg pain on walking	1.1	1.4	5.2	1.9	2.3	0.5	0.9	0.5	1.4	0.6	-0.5	-0.1
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	4.5	1.7	2.1	-0.2	1.2	1.1	1.1	1.4	-0.0	1.0
Commuting to job workplace: Car/motor vehicle	1.5	1.7	2.8	1.6	1.7	-0.7	1.5	1.3	0.7	1.2	0.9	1.6
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	3.7	-1.7	-1.3	1.8	-1.8	-1.9	-1.6	-1.4	-0.7	-0.7
Medication: Aspirin	0.9	1.1	2.9	1.7	1.7	0.6	1.2	0.6	1.1	0.9	0.5	-0.2
Supplements: Vitamin C	0.3	0.3	1.1	-0.2	0.3	-0.4	1.0	0.6	0.4	0.7	0.6	-0.1
Knee pain experienced in last month	3.4	5.3	12.7	3.0	3.6	-1.4	1.8	2.1	2.5	2.2	-0.1	2.3
Hypertension (Self-reported)	2.7	7.4	14.9	3.9	2.7	-1.4	2.9	3.0	1.4	2.5	3.0	2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.3	5.0	9.3	2.6	1.8	-1.2	2.8	2.5	0.5	2.1	3.0	2.4
Illnesses of father: Heart disease	0.5	0.8	2.1	-1.4	-1.1	-0.1	-0.8	-0.5	-1.4	-0.3	0.5	0.7
Illnesses of siblings: Diabetes	0.6	0.8	2.7	1.7	1.6	0.4	0.4	0.6	0.0	0.2	0.7	0.8
Smoking status: Previous	6.2	9.2	14.3	3.8	3.8	-0.9	3.6	3.0	2.3	3.4	2.7	2.7
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	3.6	-0.5	-1.6	-1.9	0.1	1.0	-0.1	0.3	1.7	1.0
Whole body fat-free mass	0.9	4.9	18.2	0.3	-1.4	-4.3	0.5	2.7	1.4	1.8	2.5	2.2
Leg fat-free mass (right)	0.4	1.9	7.1	-0.0	-1.4	-2.7	-0.1	1.5	1.2	0.9	1.6	0.8
Arm fat percentage (left)	0.4	1.8	5.1	0.0	0.5	1.8	-1.0	-1.5	0.3	-1.0	-1.8	-2.3
Average weekly red wine intake	1.3	2.0	5.6	1.4	1.0	-0.6	1.8	1.6	1.2	1.1	2.4	0.8
Handedness (chirality/laterality): Left-handed	1.2	1.5	7.3	1.7	1.0	0.3	0.3	0.4	2.7	0.4	1.1	-0.6
Mood swings	0.6	1.0	2.0	0.9	1.4	-0.7	1.2	0.9	1.2	1.4	-0.3	0.1
Loneliness, isolation	1.2	1.6	3.7	1.0	1.3	-1.9	1.0	1.3	1.0	1.4	-0.5	1.4
Long-standing illness, disability or infirmity	2.5	3.8	10.8	2.4	3.3	-1.4	1.1	1.7	2.2	1.5	-0.6	1.9
Ever had bowel cancer screening	0.6	0.7	1.7	1.3	0.5	-1.1	0.4	1.0	0.4	0.3	0.8	1.0
Diabetes diagnosed by doctor	0.4	0.7	1.5	0.5	1.0	-1.2	0.2	0.9	1.1	0.5	0.3	0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	2.4	1.0	0.6	-1.4	1.2	1.5	1.1	1.2	1.4	1.6
Friendships satisfaction	1.9	2.4	4.5	1.7	0.7	-1.1	1.7	1.8	1.3	1.6	2.1	1.4
Qualifications: nursing, teaching	0.9	1.4	7.8	-1.3	-2.8	-0.5	-0.5	-0.5	0.0	-0.5	1.2	-1.0
Commuting to job workplace: Walk	0.5	0.5	1.2	0.5	0.8	1.1	-0.4	-0.6	0.6	0.1	-1.0	-0.9
Eye problems/disorders: Cataract	0.3	0.4	0.9	-0.8	-0.1	-0.1	-1.0	-0.2	-0.9	-0.3	-0.5	0.8
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	2.9	0.3	0.7	0.3	0.9	0.2	-1.7	-0.1	0.3	1.0
Medication for cholesterol	1.5	2.3	6.8	-2.2	-2.6	0.6	-1.6	-1.5	-1.2	-1.1	-0.7	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.3	2.7	5.5	1.6	2.3	-1.6	1.1	1.5	1.3	2.0	-0.8	2.0
Back pain experienced in last month	0.4	0.7	2.1	0.5	-0.1	-1.3	-0.2	0.7	1.5	1.0	-0.2	0.5
Mineral and other dietary supplements	3.7	5.0	11.2	-1.8	-0.5	2.3	-2.2	-2.9	-1.2	-2.2	-3.4	-2.2
Breast cancer (self-reported)	0.7	0.9	2.1	0.9	1.1	-0.9	0.5	0.9	0.4	1.3	-0.2	1.4
Asthma (self-reported)	0.2	0.5	0.9	-0.5	-0.3	0.9	-0.6	-0.9	-0.6	-0.8	-0.8	-0.8
Osteoporosis (self-reported)	0.6	0.8	2.1	0.7	1.2	1.2	-0.5	-0.7	0.1	-0.6	-1.4	-0.7
Osteoarthritis (self-reported)	3.1	4.1	6.4	2.1	2.0	-2.3	1.9	2.5	1.5	2.0	1.2	2.3
Medication: Aspirin	0.5	0.7	1.9	1.4	1.4	0.9	0.8	0.2	0.5	0.3	0.3	-0.5
Medication: Gliclazide	0.7	0.8	2.0	0.1	1.2	1.4	-0.3	-0.9	-0.7	-0.8	-1.0	-0.7
Illnesses of father: None of the above (group 1)	0.7	0.9	6.1	-0.2	0.4	-0.5	-0.7	-0.3	0.5	-0.4	-2.5	-0.7
Smoking status: Current	0.6	1.0	3.8	0.3	1.5	0.6	0.1	-0.5	0.9	-0.1	-2.0	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.6	0.8	-0.0	0.2	0.3	0.4	0.2	0.6	1.1	1.3
Whole body water mass	0.9	5.1	18.2	0.4	-1.3	-4.3	0.7	2.8	1.5	1.8	2.6	2.2
Leg predicted mass (right)	0.3	1.8	6.8	0.1	-1.4	-2.6	-0.1	1.5	1.2	0.9	1.6	0.8
Arm fat mass (left)	0.1	0.3	1.0	0.1	-0.0	-0.0	-0.7	-0.4	0.7	-0.3	-0.8	-1.0
Number of self-reported non-cancer illnesses	1.8	3.1	8.0	2.8	2.7	-0.2	2.0	1.6	0.9	0.7	1.8	1.2
Average weekly champagne plus white wine intake	0.3	0.4	1.1	0.2	-0.5	0.5	0.7	-0.0	-0.4	-0.2	1.1	-1.0
Miserableness	0.8	1.3	3.0	1.7	1.7	-0.8	1.3	1.0	1.1	1.1	-0.6	-0.2
Guilty feelings	0.7	1.0	2.9	0.5	1.7	-0.8	0.8	0.5	0.9	1.0	-1.6	-0.1
Wears glasses or contact lenses	0.5	0.6	2.2	0.8	0.0	-0.3	0.3	0.8	-0.2	0.3	1.5	1.2
Ever taken oral contraceptive pill	0.7	0.8	2.2	1.5	1.5	-0.0	1.2	0.5	0.3	0.3	0.4	0.7
Hearing aid user	0.6	0.7	2.0	0.3	1.2	-0.5	0.0	0.4	-0.1	0.8	-1.4	1.2
Mother’s age at death	0.5	0.7	1.2	0.2	0.1	-1.1	1.0	1.0	1.1	1.1	0.4	0.3
Financial situation satisfaction	0.9	1.2	3.8	1.5	1.9	0.4	1.2	0.7	0.5	1.1	0.5	0.9
Tinnitus: Yes, now most or all of the time	2.5	3.0	5.5	1.1	1.1	-2.2	1.8	2.3	1.5	2.2	1.3	1.5
Commuting to job workplace: Public transport	0.3	0.3	1.5	-0.3	-1.2	-0.7	-0.6	0.2	0.5	0.3	0.3	0.1
Eye problems/disorders: Glaucoma	1.7	2.0	4.6	1.8	0.0	-1.7	1.1	1.7	1.1	1.0	2.1	0.9
Medication: Blood pressure	4.6	8.8	13.2	3.6	3.6	-2.0	3.1	3.4	2.4	2.9	2.2	3.0
Pain type(s) experienced in last month: Hip pain	2.1	2.7	7.0	2.7	2.1	-0.5	1.9	1.6	1.0	1.2	1.2	1.4
Supplements: Fish oil (including cod liver oil)	2.6	3.4	8.0	1.2	-0.1	-2.1	1.6	2.3	1.3	1.8	2.8	1.8
High cholesterol (Self-reported)	0.6	1.0	3.0	-0.7	0.8	1.5	-0.1	-0.9	-1.7	-1.1	-0.3	-0.6
Medication: Bendroflumethiazide	3.0	4.5	10.6	3.2	2.3	-0.7	2.2	2.3	1.5	1.5	2.5	1.7
Medication: Paracetamol	5.5	8.5	13.8	3.7	3.2	-1.4	3.7	3.0	2.5	2.8	3.0	2.1
Medication: Lisinopril	5.7	7.4	17.3	3.9	4.2	-0.7	3.0	2.4	2.7	2.5	1.2	2.0
Medication: Atorvastatin	0.2	0.3	1.6	-0.2	0.3	0.0	-0.3	-0.1	-1.3	-0.3	-0.5	0.5
Illnesses of father: High blood pressure	4.0	4.9	10.6	2.5	1.2	-1.0	2.5	2.4	1.6	2.4	3.3	2.1
Alcohol drinker status: Never	0.9	1.1	4.0	0.1	0.8	1.1	-1.5	-1.0	-0.1	-0.6	-2.0	-0.7
Ever smoked	8.1	14.2	21.8	4.3	4.7	-1.8	4.6	3.8	4.0	4.4	2.6	2.3
Basal metabolic rate	0.6	3.5	13.8	0.2	-1.3	-3.7	0.3	2.3	1.3	1.4	2.1	1.7
Leg fat percentage (left)	0.1	0.3	1.3	0.7	1.1	0.3	-0.0	-0.2	0.2	0.0	-1.0	-0.4
Arm fat-free mass (left)	0.8	4.2	16.9	0.2	-1.2	-4.1	0.4	2.5	1.0	1.6	2.1	2.2
Number of operations (self-reported)	0.2	0.3	0.9	0.2	0.4	-0.8	-0.2	0.4	1.0	0.4	-0.3	0.2
Average weekly beer plus cider intake	0.7	1.0	5.4	0.2	1.1	0.5	-1.0	-0.7	0.5	-0.4	-2.3	-0.1
Irritability	0.1	0.2	0.7	-0.1	-0.2	-0.8	0.5	0.3	0.3	0.4	-0.3	-0.2
Risk taking	0.9	1.4	2.9	-0.6	-0.1	1.0	-0.8	-1.6	-0.6	-1.7	-1.6	-1.5
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.4	-0.2	0.4	-0.4	0.2	0.6	1.1	1.2	-0.2	-0.1
Fractured/broken bones in last 5 years	0.1	0.1	0.5	0.0	-0.7	-0.5	-0.5	0.2	0.4	0.0	0.1	-0.1
Age started oral contraceptive pill	1.3	1.6	3.8	-1.1	-1.9	0.2	-1.8	-0.8	-1.8	-1.5	0.3	0.1
Diastolic blood pressure, automated reading	1.2	3.7	8.2	2.9	1.9	-0.5	2.2	2.1	0.9	1.7	2.5	1.6
Ever depressed for a whole week	0.7	0.9	2.8	-0.4	-0.6	-1.7	0.1	1.0	-0.5	0.8	0.1	1.6
Unable to work because of sickness or disability	6.7	8.7	23.3	4.8	4.7	-0.6	3.1	2.5	3.0	2.0	1.1	1.4
Commuting to job workplace: Cycle	2.1	2.5	4.5	-2.1	-1.8	1.3	-1.3	-1.7	-1.5	-1.7	-0.7	-1.8
Myopia	0.4	0.6	2.2	-0.8	-1.5	0.3	-0.5	-0.6	-1.1	-0.9	0.5	-0.3
Vascular/heart problems diagnosed by doctor	3.1	8.3	16.2	-4.0	-2.6	1.4	-3.1	-3.2	-1.5	-2.5	-3.6	-2.8
Cholesterol lowering medication	0.2	0.3	1.4	0.5	1.2	0.4	0.0	-0.1	-0.3	-0.8	-0.5	-0.0
Medication: Omeprazole (e.g. Zanprol)	1.8	2.1	6.5	2.5	2.2	-0.5	1.8	1.2	1.1	0.9	0.4	0.8
Pain experienced in last month	2.1	3.5	5.9	-2.3	-2.0	1.7	-1.1	-1.8	-2.4	-2.1	0.0	-2.1
Supplements: Calcium	2.9	3.2	9.6	-1.1	-0.4	1.6	-2.6	-1.9	-0.8	-1.5	-3.1	-1.4
Basal cell carcinoma (self-reported)	0.4	0.5	1.2	0.9	0.7	-0.5	0.2	0.7	1.1	0.8	0.0	0.4
Heart attack/myocardial infarction (self-reported)	0.8	1.0	2.9	-0.3	0.2	1.7	-0.7	-1.2	-1.1	-1.1	-1.0	-1.0
Deep venous thrombosis (DVT) (self-reported)	2.0	2.6	5.9	2.4	1.6	-1.1	1.7	1.8	2.1	1.3	1.4	0.4
Heart disease (siblings)	2.7	3.3	9.2	-0.3	-0.2	3.0	-2.1	-2.3	-1.1	-2.0	-1.6	-1.6
Alcohol drinker status: Previous	1.7	1.9	2.9	1.6	1.4	-1.0	1.7	1.7	1.2	1.2	1.6	0.7
Pack years of smoking	2.0	2.9	8.0	2.2	2.8	-1.4	1.3	1.2	2.5	1.1	-0.9	0.6
Impedance of whole body	1.5	7.8	12.1	-3.5	-3.0	2.2	-2.7	-3.1	-2.6	-3.0	-2.1	-2.5
Leg fat mass (left)	0.1	0.3	1.0	0.8	0.6	-0.8	0.1	0.5	1.0	0.5	-0.0	0.0
Arm predicted mass (left)	1.1	5.5	20.9	0.5	-1.0	-4.6	0.7	2.9	1.6	2.0	2.4	2.6