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chr17:55,704,465-58,853,216

Best TWAS P=5.93e-53 · Best GWAS P=6.86e-57 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
37	GTEx	Nerve Tibial	RPS6KB1	0.05	0.01	lasso	4	0.00	1.6e-01	-15.8	15.3	5.9e-53	-0.89	0.03	0.64	TRUE
20	GTEx	Cells Transformed fibroblasts	RPS6KB1	0.11	0.07	lasso	5	0.06	2.0e-05	-13.1	13.2	9.4e-40	-0.73	0.12	0.80	TRUE
4	GTEx	Adipose Visceral Omentum	RP11-567L7.5	0.14	0.00	enet	37	0.01	1.1e-01	-6.2	-8.6	6.7e-18	0.25	0.06	0.14	TRUE
32	GTEx	Heart Atrial Appendage	AC005702.4	0.14	0.11	enet	9	0.12	7.2e-06	-6.1	-8.0	1.3e-15	0.31	0.78	0.03	TRUE
21	GTEx	Cells Transformed fibroblasts	RNFT1	0.07	0.03	enet	11	0.05	9.1e-05	-7.8	6.5	8.3e-11	-0.43	0.22	0.10	TRUE
27	GTEx	Esophagus Gastroesophageal Junction	AC005702.4	0.16	0.10	lasso	3	0.08	1.1e-03	-6.1	-6.2	4.0e-10	0.12	0.14	0.05	TRUE
73	The Cancer Genome Atlas	Lung Adenocarcinoma	BZRAP1	0.12	0.05	blup	60	0.08	3.4e-09	2.8	-5.5	4.6e-08	0.05	0.80	0.05	TRUE
6	GTEx	Artery Aorta	BZRAP1-AS1	0.19	0.01	lasso	11	0.03	6.6e-03	2.9	5.3	1.1e-07	-0.06	0.11	0.18	TRUE
24	GTEx	Colon Sigmoid	RP11-567L7.5	0.14	0.06	lasso	4	0.10	1.6e-04	-15.3	-15.2	4.0e-52	0.77	0.03	0.83	FALSE
62	NTR	Blood	MIR21	0.01	0.02	lasso	2	0.02	9.0e-06	-15.4	-15.0	7.8e-51	0.87	0.02	0.98	FALSE
63	YFS	Blood	DHX40	0.01	0.01	lasso	8	0.01	1.6e-03	-15.9	14.5	2.4e-47	-0.87	0.02	0.96	FALSE
79	The Cancer Genome Atlas	Thyroid Carcinoma	TUBD1	0.03	0.01	blup	38	0.02	3.0e-03	-15.7	12.8	1.7e-37	-0.77	0.01	0.82	FALSE
67	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RNFT1	0.02	0.02	lasso	4	0.02	2.2e-03	-7.8	11.8	2.8e-32	-0.68	0.01	0.66	FALSE
60	METSIM	Adipose	RNFT1	0.08	0.05	enet	18	0.07	4.1e-11	-14.3	11.7	1.2e-31	-0.68	0.71	0.29	FALSE
42	GTEx	Skin Not Sun Exposed Suprapubic	DHX40	0.16	0.05	lasso	4	0.08	4.9e-05	-9.5	-11.6	6.3e-31	0.64	0.28	0.22	FALSE
72	The Cancer Genome Atlas	Brain Lower Grade Glioma	TUBD1	0.03	0.01	blup	38	0.02	3.5e-03	-5.1	11.0	4.3e-28	-0.69	0.02	0.59	FALSE
11	GTEx	Artery Tibial	RP11-567L7.5	0.19	0.14	lasso	5	0.14	9.6e-11	8.6	-10.4	2.9e-25	0.40	1.00	0.00	FALSE
78	The Cancer Genome Atlas	Soft Tissue Sarcoma	CLTC	0.07	0.03	lasso	3	0.02	1.5e-02	-9.8	-10.3	5.9e-25	0.63	0.05	0.18	FALSE
33	GTEx	Lung	DHX40	0.11	0.04	lasso	8	0.09	4.1e-07	-9.6	-10.3	7.4e-25	0.55	0.48	0.30	FALSE
50	GTEx	Testis	DHX40	0.24	0.13	lasso	10	0.18	2.6e-08	-9.1	-9.7	2.5e-22	0.51	1.00	0.00	FALSE
43	GTEx	Skin Not Sun Exposed Suprapubic	RP11-567L7.5	0.22	0.14	lasso	6	0.11	1.2e-06	8.6	-9.7	3.1e-22	0.40	0.86	0.11	FALSE
76	The Cancer Genome Atlas	Prostate Adenocarcinoma	RNFT1	0.03	0.03	enet	12	0.02	3.0e-03	-7.7	9.7	4.0e-22	-0.56	0.04	0.50	FALSE
64	YFS	Blood	RNFT1	0.04	0.04	lasso	3	0.04	9.3e-14	-7.8	9.6	6.5e-22	-0.56	1.00	0.00	FALSE
31	GTEx	Heart Atrial Appendage	RP11-567L7.5	0.20	0.13	lasso	4	0.09	9.5e-05	8.6	-9.5	1.8e-21	0.38	0.29	0.36	FALSE
18	GTEx	Breast Mammary Tissue (Male)	AC005702.4	0.48	0.22	enet	19	0.24	2.2e-06	-6.1	-9.3	9.9e-21	0.31	0.12	0.11	FALSE
65	YFS	Blood	RPS6KB1	0.01	0.01	blup	272	0.01	1.1e-03	-12.9	9.2	2.4e-20	-0.51	0.17	0.36	FALSE
75	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RNFT1	0.23	0.07	enet	18	0.13	6.3e-06	-7.7	9.1	6.1e-20	-0.56	0.01	0.94	FALSE
28	GTEx	Esophagus Mucosa	DHX40	0.14	0.10	lasso	7	0.07	3.1e-05	-9.1	-9.1	9.8e-20	0.48	0.99	0.00	FALSE
54	GTEx	Thyroid	DHX40	0.07	0.04	lasso	7	0.03	1.7e-03	-9.1	-9.0	2.5e-19	0.50	0.22	0.34	FALSE
35	GTEx	Muscle Skeletal	RP11-567L7.5	0.16	0.06	enet	12	0.06	1.8e-06	-5.3	-8.9	4.3e-19	0.27	0.97	0.00	FALSE
61	METSIM	Adipose	RPS6KB1	0.03	0.02	lasso	6	0.02	2.4e-04	-7.8	-8.9	4.3e-19	0.52	0.74	0.16	FALSE
71	The Cancer Genome Atlas	Brain Lower Grade Glioma	RPS6KB1	0.03	0.02	enet	7	0.02	8.0e-04	-5.1	8.8	1.1e-18	-0.52	0.08	0.19	FALSE
46	GTEx	Skin Sun Exposed Lower leg	RP11-567L7.5	0.12	0.11	lasso	2	0.11	4.3e-09	8.6	-8.8	1.6e-18	0.33	1.00	0.00	FALSE
7	GTEx	Artery Aorta	RP11-567L7.5	0.13	0.09	lasso	3	0.09	1.5e-05	8.6	-8.6	5.8e-18	0.34	0.77	0.02	FALSE
53	GTEx	Testis	CTD-2319I12.4	0.24	0.15	enet	23	0.19	6.3e-09	-5.1	8.6	8.7e-18	-0.41	0.76	0.20	FALSE
1	CommonMind	Brain Pre-frontal Cortex	RNFT1	0.10	0.02	bslmm	248	0.04	1.2e-05	-15.4	8.6	9.7e-18	-0.57	0.19	0.66	FALSE
45	GTEx	Skin Sun Exposed Lower leg	DHX40	0.07	0.00	enet	38	0.00	2.3e-01	-10.4	-8.5	2.6e-17	0.34	0.09	0.09	FALSE
25	GTEx	Colon Sigmoid	AC005702.4	0.21	0.22	enet	18	0.20	1.6e-07	-5.6	-8.4	3.0e-17	0.39	0.70	0.08	FALSE
2	GTEx	Adipose Subcutaneous	RP11-567L7.5	0.16	0.07	lasso	9	0.06	1.5e-05	8.6	-8.4	3.6e-17	0.33	0.93	0.00	FALSE
77	The Cancer Genome Atlas	Prostate Adenocarcinoma	RPS6KB1	0.03	0.03	enet	15	0.03	5.2e-04	-7.8	-8.2	1.9e-16	0.49	0.23	0.09	FALSE
13	GTEx	Brain Caudate basal ganglia	CLTC	0.22	0.02	lasso	4	0.01	1.8e-01	-4.7	-8.2	2.6e-16	0.60	0.05	0.46	FALSE
19	GTEx	Cells EBV-transformed lymphocytes	RNFT1	0.18	0.10	lasso	4	0.09	7.3e-04	-7.8	8.2	2.7e-16	-0.48	0.30	0.07	FALSE
68	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RPS6KB1	0.02	0.02	blup	43	0.02	6.3e-03	-7.7	-8.2	3.2e-16	0.47	0.07	0.14	FALSE
41	GTEx	Pituitary	AC005702.4	0.31	0.26	enet	9	0.23	1.9e-06	-5.6	-8.2	3.7e-16	0.31	0.47	0.12	FALSE
34	GTEx	Lung	RP11-567L7.5	0.10	0.07	lasso	5	0.05	1.6e-04	7.2	-8.1	5.4e-16	0.30	0.89	0.00	FALSE
57	GTEx	Vagina	HEATR6	0.28	0.02	lasso	10	0.01	1.8e-01	-10.4	-8.1	5.6e-16	0.51	0.04	0.33	FALSE
36	GTEx	Muscle Skeletal	AC005702.4	0.18	0.08	lasso	6	0.13	5.8e-13	-7.8	-8.0	1.2e-15	0.37	1.00	0.00	FALSE
58	GTEx	Vagina	AC005702.4	0.19	0.10	enet	18	0.09	3.8e-03	-7.8	-8.0	1.2e-15	0.46	0.23	0.13	FALSE
23	GTEx	Cells Transformed fibroblasts	AC005702.4	0.16	0.12	lasso	4	0.11	1.6e-08	-7.9	-8.0	1.5e-15	0.44	1.00	0.00	FALSE
66	The Cancer Genome Atlas	Breast Invasive Carcinoma	RPS6KB1	0.02	0.02	lasso	1	0.01	1.2e-03	-7.8	-7.8	4.4e-15	0.46	0.45	0.16	FALSE
14	GTEx	Brain Cerebellar Hemisphere	RP11-567L7.5	0.27	0.13	lasso	6	0.19	1.1e-05	-6.2	-7.8	5.2e-15	0.25	0.22	0.04	FALSE
55	GTEx	Thyroid	RP11-567L7.5	0.14	0.12	lasso	4	0.12	2.9e-09	7.2	-7.7	1.4e-14	0.25	1.00	0.00	FALSE
9	GTEx	Artery Coronary	RP11-567L7.5	0.24	0.03	lasso	5	0.02	6.1e-02	7.2	-7.6	2.4e-14	0.29	0.14	0.05	FALSE
59	GTEx	Whole Blood	AC005702.4	0.07	0.03	lasso	4	0.02	2.1e-03	-7.7	-7.6	2.8e-14	0.39	0.22	0.08	FALSE
8	GTEx	Artery Aorta	AC005702.4	0.26	0.15	lasso	6	0.17	7.2e-10	-5.6	-7.6	3.2e-14	0.26	1.00	0.00	FALSE
12	GTEx	Artery Tibial	AC005702.4	0.21	0.10	lasso	11	0.18	2.7e-14	-5.6	-7.5	8.4e-14	0.35	1.00	0.00	FALSE
49	GTEx	Stomach	AC005702.4	0.15	0.12	enet	23	0.09	3.9e-05	-5.6	-7.4	9.8e-14	0.39	0.34	0.07	FALSE
22	GTEx	Cells Transformed fibroblasts	RP11-567L7.5	0.19	0.08	enet	16	0.07	1.2e-05	8.6	-7.3	3.5e-13	0.28	0.99	0.00	FALSE
40	GTEx	Ovary	AC005702.4	0.39	0.10	enet	28	0.24	1.1e-06	-7.7	-7.2	4.9e-13	0.41	0.12	0.19	FALSE
3	GTEx	Adipose Subcutaneous	AC005702.4	0.19	0.08	lasso	7	0.12	4.0e-10	-5.6	-7.2	7.9e-13	0.34	1.00	0.00	FALSE
15	GTEx	Brain Cerebellar Hemisphere	AC005702.4	0.39	0.30	lasso	6	0.28	6.7e-08	-5.6	-7.1	1.4e-12	0.33	0.35	0.05	FALSE
70	The Cancer Genome Atlas	Brain Lower Grade Glioma	RNFT1	0.15	0.03	enet	13	0.05	8.2e-07	-5.1	7.0	3.7e-12	-0.47	0.02	0.65	FALSE
26	GTEx	Colon Transverse	AC005702.4	0.14	0.05	lasso	4	0.05	1.8e-03	-5.6	-6.9	5.5e-12	0.27	0.22	0.10	FALSE
16	GTEx	Brain Frontal Cortex BA9	AC005702.4	0.16	0.22	enet	10	0.14	1.4e-04	-5.6	-6.8	8.0e-12	0.29	0.16	0.08	FALSE
44	GTEx	Skin Not Sun Exposed Suprapubic	AC005702.4	0.11	0.14	lasso	4	0.14	6.0e-08	-5.6	-6.7	2.4e-11	0.28	0.83	0.01	FALSE
47	GTEx	Skin Sun Exposed Lower leg	AC005702.4	0.16	0.11	lasso	10	0.10	2.4e-08	-5.6	-6.6	3.3e-11	0.23	1.00	0.00	FALSE
30	GTEx	Esophagus Muscularis	AC005702.4	0.28	0.11	enet	17	0.11	3.6e-07	-6.1	-6.5	7.8e-11	0.18	0.98	0.00	FALSE
48	GTEx	Stomach	RNFT1	0.10	0.00	enet	10	0.01	1.6e-01	-5.5	6.1	9.2e-10	-0.31	0.07	0.07	FALSE
38	GTEx	Nerve Tibial	RP11-567L7.5	0.15	0.11	enet	15	0.11	6.3e-08	8.6	-6.1	1.0e-09	0.15	1.00	0.00	FALSE
52	GTEx	Testis	AC005702.4	0.32	0.27	enet	17	0.26	3.9e-12	-5.6	-6.1	1.0e-09	0.25	1.00	0.00	FALSE
56	GTEx	Thyroid	AC005702.4	0.28	0.24	lasso	5	0.22	3.7e-17	-5.6	-6.0	2.0e-09	0.23	1.00	0.00	FALSE
17	GTEx	Breast Mammary Tissue	AC005702.4	0.26	0.18	lasso	6	0.17	5.4e-09	-5.6	-6.0	2.4e-09	0.22	0.99	0.00	FALSE
74	The Cancer Genome Atlas	Lung Adenocarcinoma	RNFT1	0.04	0.02	blup	26	0.02	9.9e-04	-7.8	5.7	1.2e-08	-0.38	0.02	0.14	FALSE
5	GTEx	Adrenal Gland	AC005702.4	0.25	0.18	lasso	7	0.15	6.5e-06	-5.6	-5.7	1.5e-08	0.19	0.41	0.04	FALSE
39	GTEx	Nerve Tibial	AC005702.4	0.34	0.22	lasso	7	0.21	3.8e-15	-5.6	-5.5	3.2e-08	0.19	1.00	0.00	FALSE
10	GTEx	Artery Coronary	AC005702.4	0.21	0.02	lasso	5	0.03	2.9e-02	-7.8	-5.5	3.8e-08	0.38	0.27	0.07	FALSE
69	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MKS1	0.09	0.00	blup	50	0.03	1.3e-02	10.2	-5.4	7.0e-08	-0.06	0.00	0.50	FALSE
51	GTEx	Testis	BZRAP1-AS1	0.19	0.07	enet	10	0.10	4.8e-05	6.1	5.3	1.4e-07	0.06	0.00	0.98	FALSE
29	GTEx	Esophagus Mucosa	AC005702.4	0.34	0.19	lasso	4	0.18	7.1e-12	-6.1	-5.1	2.7e-07	0.04	1.00	0.00	FALSE