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chr17:44,788,310-48,347,817

Best TWAS P=2.39e-14 · Best GWAS P=5.85e-13 conditioned to 0.0251

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
42	The Cancer Genome Atlas	Soft Tissue Sarcoma	CDK5RAP3	0.13	0.02	blup	61	0.04	1.2e-03	-6.6	-7.6	2.4e-14	0.78	0.00	0.98	TRUE
23	GTEx	Pancreas	RP5-1029K10.2	0.20	0.00	enet	49	0.06	2.3e-03	4.1	6.0	2.2e-09	-0.01	0.06	0.29	TRUE
9	GTEx	Brain Cerebellar Hemisphere	WNT3	0.24	0.02	enet	12	0.05	2.0e-02	-4.0	5.5	2.8e-08	0.04	0.02	0.37	TRUE
36	The Cancer Genome Atlas	Brain Lower Grade Glioma	PRR15L	0.08	0.01	blup	60	0.03	1.9e-04	-6.1	-7.6	4.1e-14	0.68	0.01	0.99	FALSE
1	CommonMind	Brain Pre-frontal Cortex	PNPO	0.15	0.06	bslmm	383	0.09	3.3e-11	5.8	7.4	1.2e-13	-0.44	0.95	0.05	FALSE
11	GTEx	Brain Frontal Cortex BA9	PNPO	0.20	0.08	enet	19	0.13	2.5e-04	5.4	7.1	1.3e-12	-0.46	0.22	0.22	FALSE
43	The Cancer Genome Atlas	Thyroid Carcinoma	NFE2L1	0.04	0.05	lasso	3	0.04	1.9e-04	-6.3	-7.0	1.8e-12	0.88	0.01	0.96	FALSE
16	GTEx	Esophagus Mucosa	NFE2L1	0.07	0.02	lasso	4	0.01	8.6e-02	-7.2	-7.0	2.2e-12	0.98	0.01	0.98	FALSE
39	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SNX11	0.06	0.06	lasso	3	0.05	2.8e-06	-7.2	7.0	2.2e-12	-0.99	0.00	1.00	FALSE
14	GTEx	Cells Transformed fibroblasts	RP11-6N17.6	0.07	0.05	lasso	10	0.07	9.3e-06	5.8	7.0	2.7e-12	-0.40	0.71	0.18	FALSE
13	GTEx	Breast Mammary Tissue (Male)	PNPO	0.15	-0.01	enet	11	0.01	2.4e-01	6.0	7.0	3.7e-12	-0.29	0.06	0.09	FALSE
40	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PNPO	0.09	0.01	blup	57	0.04	9.5e-03	5.4	6.8	1.1e-11	-0.48	0.02	0.35	FALSE
25	GTEx	Skin Not Sun Exposed Suprapubic	RP11-6N17.6	0.09	0.02	enet	6	0.03	5.6e-03	-4.3	6.8	1.2e-11	-0.65	0.07	0.60	FALSE
4	GTEx	Artery Aorta	PNPO	0.11	0.08	lasso	6	0.08	2.9e-05	6.0	6.7	1.6e-11	-0.31	0.75	0.16	FALSE
35	The Cancer Genome Atlas	Brain Lower Grade Glioma	PNPO	0.22	0.07	blup	57	0.08	6.0e-09	-6.4	6.7	1.8e-11	-0.66	0.00	1.00	FALSE
3	GTEx	Adipose Subcutaneous	RP11-6N17.6	0.07	0.02	enet	16	0.03	2.0e-03	5.8	6.6	4.2e-11	-0.28	0.49	0.05	FALSE
30	The Cancer Genome Atlas	Colon Adenocarcinoma	PRR15L	0.14	0.05	lasso	4	0.10	2.0e-06	-6.1	6.6	4.6e-11	-0.79	0.00	0.99	FALSE
26	GTEx	Skin Sun Exposed Lower leg	RP11-6N17.6	0.07	0.02	enet	12	0.04	1.6e-04	-4.3	6.5	7.9e-11	-0.65	0.22	0.33	FALSE
44	The Cancer Genome Atlas	Thyroid Carcinoma	PNPO	0.07	0.03	blup	57	0.06	2.1e-06	-3.8	6.5	9.4e-11	-0.53	0.73	0.26	FALSE
18	GTEx	Esophagus Muscularis	PNPO	0.14	0.10	lasso	4	0.16	8.1e-10	6.0	6.5	1.1e-10	-0.21	0.80	0.20	FALSE
20	GTEx	Esophagus Muscularis	RP11-6N17.6	0.10	0.11	enet	12	0.08	2.4e-05	6.0	6.4	2.0e-10	-0.17	0.62	0.16	FALSE
21	GTEx	Muscle Skeletal	RP11-6N17.6	0.06	0.06	lasso	3	0.04	3.3e-05	5.5	6.3	2.1e-10	-0.21	0.61	0.03	FALSE
38	The Cancer Genome Atlas	Lung Adenocarcinoma	SNX11	0.05	0.03	blup	53	0.05	1.1e-06	-5.3	6.1	9.0e-10	-0.69	0.27	0.68	FALSE
34	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PRR15L	0.04	0.02	enet	6	0.04	3.9e-03	6.0	6.0	1.4e-09	-0.27	0.03	0.54	FALSE
27	GTEx	Thyroid	RP5-890E16.2	0.09	0.02	lasso	14	0.01	4.0e-02	-5.4	6.0	1.7e-09	-0.73	0.31	0.54	FALSE
5	GTEx	Artery Aorta	RP11-6N17.6	0.08	0.04	lasso	4	0.03	1.0e-02	5.4	6.0	2.0e-09	-0.21	0.34	0.07	FALSE
31	The Cancer Genome Atlas	Colon Adenocarcinoma	ZNF652	0.09	0.01	enet	12	0.05	5.5e-04	5.6	-6.0	2.7e-09	0.06	0.01	0.73	FALSE
12	GTEx	Brain Frontal Cortex BA9	RP11-6N17.6	0.19	0.02	enet	17	0.09	2.6e-03	-4.2	5.9	3.9e-09	-0.45	0.13	0.19	FALSE
19	GTEx	Esophagus Muscularis	RP5-890E16.2	0.07	0.01	lasso	8	0.01	5.1e-02	-5.3	5.7	1.6e-08	-0.87	0.04	0.80	FALSE
32	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PNPO	0.02	0.00	blup	57	0.01	1.0e-02	5.4	5.6	1.9e-08	-0.37	0.02	0.22	FALSE
6	GTEx	Artery Coronary	RP11-6N17.6	0.13	0.01	lasso	18	0.00	3.1e-01	-3.1	5.6	2.5e-08	-0.82	0.08	0.29	FALSE
10	GTEx	Brain Cerebellum	PNPO	0.17	0.15	lasso	4	0.10	6.3e-04	5.4	5.6	2.8e-08	-0.24	0.29	0.05	FALSE
33	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SNX11	0.05	0.00	blup	53	0.02	4.2e-03	-3.0	5.4	5.6e-08	-0.57	0.02	0.30	FALSE
41	The Cancer Genome Atlas	Prostate Adenocarcinoma	PRR15L	0.03	0.02	blup	62	0.03	2.0e-04	-3.2	5.4	5.7e-08	-0.39	0.13	0.68	FALSE
17	GTEx	Esophagus Mucosa	PNPO	0.12	0.13	enet	17	0.11	1.3e-07	5.4	5.4	5.8e-08	-0.22	0.96	0.03	FALSE
2	GTEx	Adipose Subcutaneous	PNPO	0.16	0.08	lasso	4	0.15	3.7e-12	3.5	5.4	6.5e-08	-0.27	0.93	0.07	FALSE
29	YFS	Blood	SKAP1	0.13	0.07	bslmm	549	0.15	2.1e-45	3.2	-5.4	7.1e-08	0.45	1.00	0.00	FALSE
37	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	MRPL10	0.12	0.04	blup	59	0.06	1.1e-03	2.5	5.2	1.7e-07	-0.18	0.02	0.12	FALSE
7	GTEx	Artery Tibial	NFE2L1	0.13	0.00	enet	9	0.00	4.9e-01	-5.3	-5.2	1.8e-07	0.67	0.07	0.29	FALSE
15	GTEx	Colon Transverse	RP5-890E16.2	0.14	0.03	lasso	7	0.02	5.9e-02	-2.6	5.2	1.9e-07	-0.70	0.08	0.66	FALSE
24	GTEx	Skin Not Sun Exposed Suprapubic	PNPO	0.14	0.10	enet	5	0.12	2.6e-07	-4.3	5.2	2.3e-07	-0.36	0.96	0.02	FALSE
22	GTEx	Nerve Tibial	PNPO	0.12	0.07	enet	16	0.09	3.9e-07	-4.3	5.2	2.6e-07	-0.36	0.98	0.01	FALSE
8	GTEx	Artery Tibial	PNPO	0.09	0.05	enet	10	0.09	1.1e-07	-3.7	5.1	2.7e-07	-0.28	0.97	0.01	FALSE
28	GTEx	Uterus	RP11-6N17.10	0.43	0.26	lasso	6	0.24	1.3e-05	-3.8	-5.1	2.8e-07	0.54	0.07	0.27	FALSE