Hub : Genes

TUBD1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 NTR Blood 0.0317 0.0159 2.5e-06 0.022 0.016 0.020 0.017 0.019 6.4e-08 3.3e-06 3.4e-07 2.3e-06 6.3e-07
2 TCGA Brain Lower Grade Glioma 0.0308 0.0220 3.8e-03 0.009 0.018 0.017 NA 0.013 2.9e-02 3.5e-03 4.6e-03 NA 1.1e-02
3 TCGA Thyroid Carcinoma 0.0350 0.0240 2.4e-03 0.012 0.022 0.002 NA 0.018 2.2e-02 3.0e-03 1.7e-01 NA 6.1e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.1 0.2 0.4 0.7 0.3 0.1
Bipolar Disorder or Schizophrenia 0.0 0.1 0.2 -0.5 -0.1 -0.3
Depressed Affect (Nagel 2018) 1.7 3.6 5.3 2.3 -1.7 -1.6
Depression (Nagel 2018) 1.4 2.0 3.0 0.5 -1.7 -1.7
Intelligence (Savage-Jansen 2018) 0.1 0.2 0.6 0.2 0.1 0.8
Neuroticism (Nagel 2018) 1.1 2.5 2.6 1.6 -1.6 -1.6
Schizophrenia (2018) 0.2 0.5 1.2 -1.1 -0.4 -0.4
Schizophrenia vs Biploar Disorder 0.6 0.8 1.1 -0.8 -1.0 -0.7
Worry (Nagel 2018) 0.3 0.7 1.1 0.3 -0.9 -1.1
Alzheimer’s Disease (in mother) 1.5 1.7 2.2 -1.1 1.3 1.5
Alzheimer’s Disease (in father) 2.1 2.3 6.3 2.5 0.2 0.6
Alzheimer’s Disease (including proxy) 0.8 1.1 1.9 0.5 1.2 1.4
Crohns Disease (2017) 4.4 9.6 16.3 -0.5 -3.5 -4.0
Irritable Bowel Disease (IBD) 2.6 6.2 11.0 -0.1 -2.8 -3.3
Ulcerative Colitis (UC) 0.4 0.8 1.2 0.8 -0.8 -1.1
Major Depression (MDD) 0.4 0.5 1.2 1.1 0.1 0.3
Reaction Time 0.7 1.4 2.0 1.0 -1.1 -1.4
Verbal and Numeric Reasoning (VNR) 0.0 0.1 0.2 -0.4 -0.1 0.3
Breast Cancer 3.0 7.2 14.8 3.9 -1.9 -1.8
Ovarian Cancer 1.7 2.2 3.1 -0.9 1.6 1.8
Prostate Cancer 0.8 1.2 1.9 -1.4 -0.9 -0.8
Age at First Birth 0.8 1.1 1.8 1.4 0.7 1.0
Bipolar Disorder (2011) 0.3 0.3 0.4 0.7 0.4 0.5
Body Mass Index (BMI) (2010) 1.1 1.5 2.4 -1.5 -1.0 -1.0
Coronary Artery Disease (CAD) 1.3 1.5 4.0 2.0 0.6 0.5
Crohns Disease (2012) 3.3 5.3 9.7 -0.5 -2.5 -3.1
Mean Putamen Volume 0.2 0.2 0.4 0.6 -0.4 -0.4
Fasting Glucose 1.4 1.7 2.7 0.1 -1.6 -1.6
HbA1C 1.6 1.8 2.7 1.1 -1.2 -1.6
HDL Cholesterol 0.5 0.8 0.9 -1.0 -0.9 -0.9
LDL Cholesterol 1.4 2.2 6.5 2.5 -0.2 0.0
Lupus 0.5 0.7 1.5 1.2 -0.4 -0.6
Neuroticism (2016) 0.9 1.3 2.0 0.2 -1.4 -1.4
Primary Biliary Cirrhosis 0.6 0.8 1.4 0.6 -0.9 -1.2
Rheumatoid Arthritis 0.4 0.6 1.6 -1.3 -0.1 -0.2
Schizophrenia (2014) 0.2 0.5 0.7 -0.4 -0.8 -0.8
Triglycerides 0.4 0.6 1.7 1.3 -0.2 -0.3
Type 2 Diabetes (T2D) (2012) 1.3 1.4 2.3 0.4 1.4 1.5
Ulcerative Colitis 0.1 0.2 0.4 0.4 -0.2 -0.6
Blood Eosinophil Count 2.6 20.3 22.3 4.1 4.7 4.7
Blood Platelet Count 0.9 10.3 18.8 0.9 3.4 4.3
Blood Red Count 1.7 16.7 29.4 -1.1 4.4 5.4
Blood White Count 12.9 95.9 163.8 1.7 11.0 12.8
Heel T-Score 0.3 2.4 5.4 2.3 1.0 0.9
BMI 0.4 2.6 4.8 -0.5 -1.6 -2.2
Height 0.6 11.5 16.1 -2.0 4.0 3.8
Waist Hip Ratio (WHR) 0.4 1.9 2.9 0.7 1.5 1.7
Systolic Blood Pressure 0.7 3.7 7.5 0.5 -1.8 -2.7
Smoking Status 0.6 1.4 3.3 -1.8 -0.8 -0.5
Allergy or Eczema 1.7 4.5 6.5 0.9 2.5 2.5
Cardiovascular Disease 0.4 1.5 1.9 0.8 -1.4 -1.4
Hypothyroidism (self reported) 0.2 0.4 0.5 -0.7 -0.5 -0.7
Respiratory disease 0.0 0.1 0.1 0.0 -0.1 -0.4
Type 2 Diabetes (T2D) (2018) 1.0 1.8 4.2 2.1 0.6 0.9
Lung FEV1/FVC ratio 0.3 1.4 2.9 0.3 -1.0 -1.7
Lung FVC 0.6 2.8 4.2 -1.2 1.7 2.0
Neuroticism 2.0 4.8 6.8 1.4 -2.4 -2.6
Chronotype (morning person) 1.0 2.4 4.2 0.9 2.1 1.5
Hair Pigment 0.1 3.9 6.4 -2.5 1.6 1.6
Tanning 0.0 0.2 0.4 0.2 -0.2 -0.6
Hand grip strength (left) 0.6 1.5 4.6 -2.1 -0.1 0.2
Number of treatments/medications taken 1.6 2.8 8.4 2.9 0.4 0.1
Average weekly spirits intake 0.1 0.1 0.1 0.2 0.4 0.4
Sensitivity / hurt feelings 5.0 8.5 13.1 -0.7 -3.4 -3.6
Frequency of depressed mood in last 2 weeks 4.1 5.8 9.2 -0.1 -3.0 -2.9
Hearing difficulty/problems: Yes 1.0 1.5 2.3 0.5 1.5 1.4
Relative age of first facial hair 0.8 1.7 2.2 1.3 1.0 1.5
Other serious medical condition/disability diagnosed by doctor 0.6 0.7 1.1 0.8 -0.7 -1.0
Ever used hormone-replacement therapy (HRT) 0.0 0.0 0.1 0.3 0.1 -0.2
Ever had hysterectomy (womb removed) 0.5 0.6 1.2 -0.1 -0.7 -1.1
Systolic blood pressure, automated reading 1.4 4.0 7.7 0.0 -2.1 -2.8
Eye problems/disorders: Diabetes related eye disease 1.4 1.5 2.2 1.0 1.1 1.5
Angina 1.4 1.9 1.9 1.4 1.4 1.3
Medication for hormone replacement therapy 0.1 0.2 0.2 -0.1 -0.5 -0.5
Vitamin and mineral supplements 0.7 0.9 1.6 -1.3 0.8 0.7
Supplements: Zinc 1.6 1.8 5.3 2.3 0.1 0.1
Medication: Co-codamol 0.3 0.3 0.5 0.2 -0.6 -0.7
Medication: Metformin 1.7 2.4 3.1 1.8 1.4 1.5
Diabetes (father) 3.1 3.8 4.6 2.2 1.7 2.0
Diabetes (mother) 0.0 0.0 0.1 0.1 0.2 0.2
Severe depression (siblings) 2.1 2.3 4.0 0.3 -2.0 -1.7
Pack years adult smoking proportion 1.9 2.9 7.6 -2.8 -0.6 -0.9
Impedance of leg (right) 0.8 3.9 7.3 1.1 1.8 2.7
Leg fat-free mass (left) 0.0 0.1 0.3 -0.6 0.2 -0.2
Trunk fat percentage 0.0 0.0 0.0 -0.1 0.2 0.2
Hand grip strength (right) 0.2 0.6 1.2 -1.1 0.4 0.7
Townsend deprivation index at recruitment 0.4 0.6 1.6 -1.2 -0.1 -0.5
Current tobacco smoking 2.3 3.8 5.4 -1.0 -2.3 -2.2
Average weekly fortified wine intake 1.0 1.2 1.8 -1.3 0.9 1.0
Maternal smoking around birth 0.4 0.6 0.9 -0.5 -0.8 -1.0
Fed-up feelings 0.3 0.6 0.9 0.7 -0.9 -0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 3.1 4.1 6.6 -0.2 -2.4 -2.6
Relative age voice broke 0.7 1.1 2.2 1.5 0.5 0.9
Taking other prescription medications 1.3 2.0 5.5 2.4 -0.2 -0.6
Age when periods started (menarche) 0.3 0.8 1.0 -1.0 0.8 0.9
Bilateral oophorectomy (both ovaries removed) 1.4 1.6 2.2 1.5 -1.2 -1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.6 1.0 1.0 -0.8 -0.6
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 1.1 -1.1 0.2 0.1
Qualifications: CSEs or equivalent 0.2 0.2 0.4 -0.7 -0.4 -0.3
Serious illness, injury or assault to yourself 1.1 1.3 2.2 -1.5 0.9 0.9
High blood pressure 0.4 1.3 2.8 1.7 -0.6 -0.8
Hayfever, allergic rhinitis or eczema 1.2 2.7 3.9 0.9 1.9 2.0
Multivitamins +/- minerals 0.5 0.6 0.8 0.9 -0.8 -0.6
Stomach or abdominal pain in last month 0.1 0.1 0.2 0.4 -0.0 -0.2
Supplements: Glucosamine 0.5 0.6 0.8 0.8 0.6 0.9
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 0.4 0.7 0.4 0.6
Medication: Atenolol 1.1 1.3 2.8 -0.1 1.7 1.1
Medication: Levothyroxine sodium 0.2 0.3 0.5 -0.5 0.7 0.3
Sitting height 0.4 3.1 8.6 -2.9 -0.4 -0.8
Chronic bronchitis/emphysema (father) 5.8 6.8 10.3 0.3 -3.2 -3.2
High blood pressure (mother) 4.1 5.8 7.9 1.4 -2.8 -2.8
Body mass index (BMI) 0.3 1.1 2.1 -0.2 -1.1 -1.4
Impedance of leg (left) 0.6 3.0 6.1 0.5 1.6 2.5
Leg predicted mass (left) 0.0 0.1 0.3 -0.5 0.2 -0.2
Trunk fat mass 0.0 0.1 0.2 -0.1 0.5 0.4
Waist circumference 0.0 0.1 0.2 0.5 0.1 0.0
Number of incorrect matches in round 0.8 1.4 4.0 2.0 0.3 0.3
Past tobacco smoking 0.3 0.5 0.8 0.7 -0.3 -0.9
Alcohol usually taken with meals 0.4 0.7 2.0 1.4 -0.3 0.1
Nervous feelings 0.9 1.6 3.0 0.1 -1.3 -1.7
Frequency of tenseness / restlessness in last 2 weeks 1.4 2.1 3.5 -0.2 -1.7 -1.9
Hearing difficulty/problems with background noise 2.7 4.4 4.9 1.9 2.1 2.2
Hair/balding pattern: Pattern 2 0.6 0.7 1.3 -0.5 0.8 1.1
Had menopause 0.3 0.3 0.5 0.4 0.7 0.5
Had other major operations 0.9 1.1 1.7 0.3 1.2 1.3
Forced vital capacity (FVC) 1.6 6.3 8.8 -1.7 2.7 3.0
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 0.6 -0.0 -0.8 -0.7
Ever unenthusiastic/disinterested for a whole week 2.0 2.5 3.9 -0.0 -2.0 -1.9
Qualifications: None of the above 0.0 0.1 0.1 -0.3 0.4 -0.2
Financial difficulties in last 2 years 0.6 0.7 1.2 -0.4 -1.1 -0.9
Mouth/teeth dental problems 2.7 4.2 5.5 2.3 1.5 2.2
Heart attack 1.9 2.4 4.3 2.1 1.3 1.1
Allergy 0.9 2.1 2.5 -1.2 -1.6 -1.6
Pain all over the body in last month 0.0 0.0 0.0 0.2 0.0 0.1
Diabetes (self-reported) 1.1 1.7 3.2 1.8 1.0 0.9
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.6 0.3 0.5 0.8
Medication: Ramipril 1.0 1.2 1.5 1.2 1.1 1.0
Medication: Simvastatin 1.4 2.1 4.8 2.2 0.8 0.9
Fluid intelligence score 0.2 0.5 1.0 -0.2 -1.0 -0.5
Illnesses of siblings 0.1 0.2 0.3 -0.5 0.2 0.4
Neuroticism score 2.8 5.9 8.2 1.4 -2.7 -2.9
Weight 0.0 0.1 0.4 -0.6 0.1 -0.2
Impedance of arm (right) 0.6 2.6 5.0 0.9 1.4 2.2
Arm fat percentage (right) 0.0 0.0 0.1 0.3 -0.1 -0.1
Trunk fat-free mass 0.0 0.1 0.3 -0.3 0.5 0.2
Hip circumference 0.1 0.2 0.3 -0.5 0.4 0.5
Time employed in main current job 1.0 1.1 2.0 -0.6 -1.0 -1.4
Alcohol intake versus 10 years previously 0.1 0.2 0.3 0.2 -0.5 -0.5
Father’s age at death 0.3 0.4 0.7 0.5 0.6 0.8
Worrier / anxious feelings 1.2 2.2 3.3 0.1 -1.8 -1.8
Frequency of tiredness / lethargy in last 2 weeks 1.1 1.7 2.4 1.2 -1.6 -1.2
Falls in the last year 1.2 1.6 4.6 2.1 -0.3 -0.2
Hair/balding pattern: Pattern 3 0.0 0.1 0.1 0.3 0.2 -0.2
Number of live births 0.1 0.2 0.3 0.5 0.6 0.3
Forced expiratory volume in 1-second (FEV1) 1.0 3.2 4.7 -1.0 2.0 2.2
Pulse rate 0.3 0.5 0.7 -0.8 0.4 0.8
Happiness 1.6 2.0 2.2 -1.2 -1.4 -1.5
Noisy workplace 0.1 0.2 0.3 0.1 -0.5 -0.4
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.5 0.1 -0.7 -0.3
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.3 -0.6 -0.2 -0.2
Mouth/teeth dental problems: Dentures 1.5 2.6 5.6 -2.4 -0.6 -1.4
Asthma 0.3 0.5 0.9 0.9 0.7 0.4
Medication: Ibuprofen (e.g. Nurofen) 1.3 1.6 4.7 2.2 0.1 0.4
Medication: Cholesterol lowering 1.9 3.0 5.0 2.2 1.4 1.4
Depression (self-reported) 3.6 4.3 6.2 -1.1 -2.4 -2.5
Medication: Lansoprazole 0.3 0.4 0.4 -0.6 0.6 0.6
Prospective memory result 0.7 0.9 1.5 0.1 1.2 1.1
Lung cancer (father) 0.6 0.7 1.1 -0.6 -0.9 -1.0
Illnesses of mother 1.8 2.2 6.3 -2.5 0.6 0.2
Forced expiratory volume in 1-second (FEV1), Best measure 1.7 5.5 8.6 -0.7 2.7 2.9
Pulse wave Arterial Stiffness index 0.9 1.0 1.1 1.0 1.1 1.0
Impedance of arm (left) 0.4 1.8 3.7 0.7 1.1 1.9
Arm fat mass (right) 0.0 0.1 0.1 -0.1 -0.2 -0.4
Trunk predicted mass 0.0 0.2 0.4 -0.3 0.6 0.3
Standing height 0.5 4.6 6.9 -0.9 2.5 2.6
Length of working week for main job 0.1 0.1 0.1 0.2 0.1 0.4
Exposure to tobacco smoke at home 1.2 1.3 4.0 -2.0 -0.1 -0.2
Breastfed as a baby 1.0 1.3 2.1 0.2 -1.4 -1.3
Tense / ‘highly strung’ 0.6 1.0 1.7 0.2 -1.1 -1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 2.2 3.4 5.3 0.9 -2.1 -2.3
Hair/balding pattern: Pattern 4 0.2 0.4 0.6 -0.7 0.8 0.4
Birth weight of first child 0.8 1.5 2.7 -0.1 -1.3 -1.7
Peak expiratory flow (PEF) 2.5 5.8 9.4 0.4 2.8 3.1
Pulse wave reflection index 1.6 2.0 3.6 1.9 1.1 1.2
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.5 0.7 0.4 0.2
Loud music exposure frequency 1.0 1.1 1.5 1.0 -0.9 -1.2
Qualifications: O levels/GCSEs or equivalent 1.1 1.7 3.7 0.5 1.1 1.9
Mouth/teeth dental problems: Bleeding gums 0.1 0.2 0.2 -0.4 0.4 0.4
Blood clot in the leg (DVT) 1.1 1.5 2.2 -0.1 1.5 1.5
Medication: Paracetamol 1.5 2.5 2.9 1.7 -1.4 -1.6
Headache pain in last month 2.1 3.5 7.9 2.8 -1.1 -1.2
Medication for cholesterol, blood pressure or diabetes 1.1 1.8 3.2 -1.8 -1.1 -1.0
Glaucoma (self-reported) 1.9 2.2 4.0 2.0 1.2 1.1
Gout (self-reported) 1.6 2.2 4.3 -2.1 -1.0 -1.2
Hypothyroidism/myxoedema (self-reported) 0.1 0.1 0.3 0.5 0.3 0.1
Medication: Amlodipine 0.3 0.4 0.6 0.8 -0.4 -0.6
Medication: Ventolin 100micrograms inhaler 0.6 0.8 0.9 0.9 -0.9 -0.9
Birth weight 0.0 0.1 0.1 -0.2 0.3 0.3
Chronic bronchitis/emphysema (mother) 5.2 6.0 9.5 -0.5 -2.9 -3.1
High blood pressure (siblings) 0.0 0.0 0.1 0.3 0.1 0.1
Forced vital capacity (FVC), Best measure 2.0 7.2 11.4 -1.1 3.0 3.4
Body fat percentage 0.0 0.0 0.1 0.1 0.2 0.2
Leg fat percentage (right) 0.1 0.3 0.5 0.3 0.6 0.7
Arm fat-free mass (right) 0.0 0.2 0.3 -0.6 0.3 -0.2
Exposure to tobacco smoke outside home 4.2 5.6 7.4 -1.6 -2.6 -2.7
Comparative body size at age 10 0.1 0.4 1.0 1.0 -0.3 -0.4
Number of full brothers 0.0 0.1 0.1 0.3 -0.2 -0.1
Worry too long after embarrassment 0.6 1.1 1.7 0.8 -1.3 -0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 3.3 4.3 5.3 1.6 -2.3 -2.3
Wheeze or whistling in the chest in last year 0.2 0.3 0.9 -1.0 0.1 -0.1
Number of children fathered 0.5 0.6 1.0 -0.1 0.9 1.0
Reason for reducing amount of alcohol drunk: Health precaution 3.6 4.2 5.1 2.0 1.9 2.3
Age at first live birth 1.0 1.7 1.9 1.2 1.4 1.3
Pulse wave peak to peak time 0.6 0.7 0.9 -1.0 -0.8 -0.7
Health satisfaction 0.1 0.2 0.3 -0.0 -0.5 -0.5
Shortness of breath walking on level ground 0.4 0.5 0.9 -0.0 1.0 0.7
Qualifications: College or University degree 0.1 0.3 0.9 0.9 -0.3 0.1
Eye problems/disorders: None of the above 0.6 0.7 1.2 0.1 -1.1 -0.9
Mouth/teeth dental problems: Loose teeth 0.4 0.4 0.7 -0.4 -0.7 -0.8
Emphysema/chronic bronchitis 1.0 1.2 3.3 -1.8 0.5 0.0
Medication for pain relief, constipation, heartburn 0.9 1.6 4.7 -2.2 -0.3 -0.2
Neck or shoulder pain in last month 0.9 1.3 2.4 1.5 0.7 1.0
Medication: Blood pressure 0.4 0.6 0.9 0.8 0.9 0.6
Angina (self-reported) 1.3 1.7 3.2 1.8 1.0 1.0
Migraine (self-reported) 2.2 2.7 4.5 0.1 -2.1 -1.9
Medication: Ibuprofen 1.1 1.3 3.4 1.8 0.4 0.7
Medication: Allopurinol 0.2 0.2 0.7 -0.8 0.0 -0.1
Medication: Omeprazole 0.5 0.6 1.0 0.0 1.0 0.9
Medication: Seretide 50 evohaler 2.3 2.7 3.5 -1.4 -1.6 -1.9
Mean time to correctly identify matches 0.5 0.9 1.6 0.7 -0.7 -1.2
Heart disease (mother) 2.5 3.0 5.1 2.3 1.3 1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.0 0.0 0.0 -0.1 -0.2 -0.1
Whole body fat mass 0.0 0.0 0.1 -0.1 0.3 0.2
Leg fat mass (right) 0.0 0.1 0.2 0.2 0.4 0.3
Arm predicted mass (right) 0.0 0.2 0.4 -0.5 -0.2 -0.6
Pulse rate, automated reading 0.4 1.2 2.4 -1.6 -0.9 -0.6
Alcohol intake frequency. 3.6 8.3 9.9 -2.9 -2.5 -3.1
Comparative height size at age 10 1.3 7.0 11.5 1.0 3.4 3.0
Number of full sisters 0.5 0.6 1.1 0.1 -1.1 -0.9
Suffer from ‘nerves’ 0.6 0.9 1.2 1.1 -0.8 -0.9
Overall health rating 0.1 0.3 0.8 -0.1 -0.3 -0.9
Chest pain or discomfort 0.5 0.7 0.9 0.9 -0.9 -0.6
Had major operations 0.0 0.0 0.1 0.2 -0.1 0.0
Age at last live birth 0.7 1.0 1.8 0.4 1.3 1.1
Family relationship satisfaction 0.2 0.2 0.5 -0.7 0.1 0.1
Leg pain on walking 0.4 0.5 1.3 1.2 -0.1 0.1
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.6 -1.2 0.2 0.1
Commuting to job workplace: Car/motor vehicle 1.6 1.8 2.8 -0.1 1.7 1.6
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 0.6 0.7 0.8 0.6
Medication: Aspirin 3.4 4.4 4.8 2.1 2.2 2.0
Supplements: Vitamin C 1.1 1.3 3.8 1.9 -0.1 0.1
Knee pain experienced in last month 1.1 1.8 2.6 0.7 -1.6 -1.5
Hypertension (Self-reported) 0.4 1.0 2.8 1.7 -0.2 -0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.3 2.7 3.8 0.7 1.9 1.9
Illnesses of father: Heart disease 2.5 3.4 4.6 2.1 1.6 1.8
Illnesses of siblings: Diabetes 0.0 0.0 0.0 0.1 0.1 0.1
Smoking status: Previous 0.3 0.5 1.0 -0.2 0.7 1.0
Forced expiratory volume in 1-second (FEV1), predicted 1.8 3.7 4.2 -1.8 1.9 2.0
Whole body fat-free mass 0.0 0.2 0.4 -0.6 0.3 -0.1
Leg fat-free mass (right) 0.1 0.4 1.2 -1.1 0.1 -0.4
Arm fat percentage (left) 0.0 0.1 0.1 0.2 -0.2 -0.3
Average weekly red wine intake 1.3 1.9 4.2 2.1 0.8 0.8
Handedness (chirality/laterality): Left-handed 1.2 1.5 2.8 -1.7 -1.1 -0.8
Mood swings 2.4 4.3 5.6 1.4 -2.4 -2.3
Loneliness, isolation 0.3 0.5 1.3 1.1 -0.2 -0.2
Long-standing illness, disability or infirmity 0.9 1.4 2.8 0.4 -1.1 -1.7
Ever had bowel cancer screening 0.2 0.2 0.4 0.6 -0.2 -0.6
Diabetes diagnosed by doctor 1.1 1.8 2.5 0.8 1.5 1.6
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.9 2.1 1.5 0.4 0.6
Friendships satisfaction 0.5 0.6 0.7 0.7 -0.9 -0.7
Qualifications: nursing, teaching 0.1 0.2 0.4 0.7 -0.1 0.1
Commuting to job workplace: Walk 2.6 2.8 5.9 2.4 -1.2 -1.0
Eye problems/disorders: Cataract 1.7 2.0 5.3 -2.3 0.6 0.5
Mouth/teeth dental problems: Mouth ulcers 5.5 8.7 12.9 -1.1 -3.5 -3.6
Medication for cholesterol 0.5 0.7 1.5 -0.4 -1.2 -0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.7 3.2 5.2 0.4 2.3 2.0
Back pain experienced in last month 0.8 1.2 2.1 0.2 1.4 1.2
Mineral and other dietary supplements 0.2 0.3 0.5 -0.7 0.5 0.4
Breast cancer (self-reported) 0.0 0.0 0.1 0.3 0.1 0.2
Asthma (self-reported) 0.3 0.5 0.8 0.9 0.7 0.5
Osteoporosis (self-reported) 1.1 1.4 2.4 0.2 -1.3 -1.5
Osteoarthritis (self-reported) 0.7 0.9 1.9 1.4 -0.6 -0.7
Medication: Aspirin 4.0 5.2 6.3 1.9 2.5 2.4
Medication: Gliclazide 2.3 2.6 7.1 2.7 0.6 0.7
Illnesses of father: None of the above (group 1) 3.2 3.9 9.4 -3.1 -1.0 -1.2
Smoking status: Current 1.9 3.0 4.2 -1.1 -2.1 -1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.1 2.4 3.4 -1.1 1.6 1.8
Whole body water mass 0.0 0.1 0.3 -0.5 0.3 -0.1
Leg predicted mass (right) 0.1 0.5 1.4 -1.2 0.0 -0.5
Arm fat mass (left) 0.0 0.0 0.1 -0.1 -0.1 -0.3
Number of self-reported non-cancer illnesses 1.2 2.0 6.0 2.5 0.3 0.1
Average weekly champagne plus white wine intake 1.4 1.9 3.1 0.8 1.3 1.8
Miserableness 4.3 7.4 9.4 3.1 -2.5 -2.6
Guilty feelings 0.3 0.4 0.7 0.4 -0.8 -0.6
Wears glasses or contact lenses 0.3 0.3 0.7 0.8 0.3 0.4
Ever taken oral contraceptive pill 0.8 0.9 1.8 -1.3 0.5 0.8
Hearing aid user 1.2 1.3 2.3 -0.2 1.5 1.3
Mother’s age at death 2.3 2.9 4.8 2.2 1.1 1.6
Financial situation satisfaction 0.8 1.0 1.4 -1.2 -1.1 -0.7
Tinnitus: Yes, now most or all of the time 0.6 0.7 1.2 0.1 0.9 1.1
Commuting to job workplace: Public transport 2.1 2.5 3.6 0.7 -1.9 -1.9
Eye problems/disorders: Glaucoma 2.2 2.6 2.8 1.5 1.7 1.6
Medication: Blood pressure 0.4 0.8 2.2 1.5 -0.1 -0.4
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.4 1.2 -0.4 -0.3
Supplements: Fish oil (including cod liver oil) 0.7 0.9 2.1 1.4 -0.5 -0.5
High cholesterol (Self-reported) 0.1 0.1 0.4 0.6 -0.0 0.2
Medication: Bendroflumethiazide 0.1 0.1 0.3 -0.5 -0.2 -0.3
Medication: Paracetamol 1.7 2.7 3.1 1.7 -1.5 -1.8
Medication: Lisinopril 1.5 2.0 5.9 2.4 0.2 0.2
Medication: Atorvastatin 4.5 5.6 7.8 -1.4 2.8 2.7
Illnesses of father: High blood pressure 0.7 0.9 1.4 1.2 0.8 0.8
Alcohol drinker status: Never 2.3 2.7 4.6 0.1 -1.9 -2.1
Ever smoked 0.1 0.1 0.4 -0.3 -0.6 -0.0
Basal metabolic rate 0.0 0.1 0.3 -0.6 0.3 -0.1
Leg fat percentage (left) 0.1 0.2 0.3 -0.1 0.6 0.6
Arm fat-free mass (left) 0.0 0.1 0.2 -0.4 0.4 0.1
Number of operations (self-reported) 0.1 0.2 0.2 0.4 0.4 0.5
Average weekly beer plus cider intake 1.4 2.0 2.7 -1.7 1.4 1.2
Irritability 1.9 3.2 3.4 1.8 -1.7 -1.8
Risk taking 1.7 2.4 6.9 -2.6 -0.3 -0.6
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.6 0.8 0.0 0.1
Fractured/broken bones in last 5 years 0.2 0.2 0.5 -0.7 0.1 0.4
Age started oral contraceptive pill 1.7 2.2 3.3 0.8 1.8 1.6
Diastolic blood pressure, automated reading 0.5 1.6 3.1 -0.3 -1.3 -1.8
Ever depressed for a whole week 4.4 5.4 7.6 -1.0 -2.7 -2.8
Unable to work because of sickness or disability 1.5 2.0 3.1 -0.9 -1.4 -1.8
Commuting to job workplace: Cycle 2.0 2.4 3.1 1.1 -1.7 -1.8
Myopia 0.3 0.5 1.5 1.2 -0.1 0.1
Vascular/heart problems diagnosed by doctor 0.6 1.7 4.8 -2.2 0.2 0.4
Cholesterol lowering medication 1.4 2.0 3.2 -0.1 1.8 1.7
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.3 -0.1 0.5 0.6
Pain experienced in last month 1.8 3.1 7.7 -2.8 0.9 0.8
Supplements: Calcium 0.0 0.0 0.0 0.2 -0.1 -0.1
Basal cell carcinoma (self-reported) 0.7 0.8 1.0 0.8 0.8 1.0
Heart attack/myocardial infarction (self-reported) 1.8 2.3 4.4 2.1 1.2 1.0
Deep venous thrombosis (DVT) (self-reported) 1.3 1.7 2.6 -0.0 1.6 1.6
Heart disease (siblings) 0.5 0.7 2.0 1.4 0.2 0.0
Alcohol drinker status: Previous 0.2 0.2 0.3 -0.4 -0.4 -0.5
Pack years of smoking 1.5 2.2 6.1 -2.5 -0.3 -0.6
Impedance of whole body 0.5 2.4 5.0 0.5 1.4 2.2
Leg fat mass (left) 0.0 0.1 0.2 -0.1 0.4 0.3
Arm predicted mass (left) 0.0 0.2 0.4 -0.7 0.3 -0.1