Hub : Genes

TUBD1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0317	0.0159	2.5e-06	0.022	0.016	0.020	0.017	0.019	6.4e-08	3.3e-06	3.4e-07	2.3e-06	6.3e-07
2	TCGA	Brain Lower Grade Glioma	0.0308	0.0220	3.8e-03	0.009	0.018	0.017	NA	0.013	2.9e-02	3.5e-03	4.6e-03	NA	1.1e-02
3	TCGA	Thyroid Carcinoma	0.0350	0.0240	2.4e-03	0.012	0.022	0.002	NA	0.018	2.2e-02	3.0e-03	1.7e-01	NA	6.1e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.1	0.2	0.4	0.7	0.3	0.1
Bipolar Disorder or Schizophrenia	0.0	0.1	0.2	-0.5	-0.1	-0.3
Depressed Affect (Nagel 2018)	1.7	3.6	5.3	2.3	-1.7	-1.6
Depression (Nagel 2018)	1.4	2.0	3.0	0.5	-1.7	-1.7
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.6	0.2	0.1	0.8
Neuroticism (Nagel 2018)	1.1	2.5	2.6	1.6	-1.6	-1.6
Schizophrenia (2018)	0.2	0.5	1.2	-1.1	-0.4	-0.4
Schizophrenia vs Biploar Disorder	0.6	0.8	1.1	-0.8	-1.0	-0.7
Worry (Nagel 2018)	0.3	0.7	1.1	0.3	-0.9	-1.1
Alzheimer’s Disease (in mother)	1.5	1.7	2.2	-1.1	1.3	1.5
Alzheimer’s Disease (in father)	2.1	2.3	6.3	2.5	0.2	0.6
Alzheimer’s Disease (including proxy)	0.8	1.1	1.9	0.5	1.2	1.4
Crohns Disease (2017)	4.4	9.6	16.3	-0.5	-3.5	-4.0
Irritable Bowel Disease (IBD)	2.6	6.2	11.0	-0.1	-2.8	-3.3
Ulcerative Colitis (UC)	0.4	0.8	1.2	0.8	-0.8	-1.1
Major Depression (MDD)	0.4	0.5	1.2	1.1	0.1	0.3
Reaction Time	0.7	1.4	2.0	1.0	-1.1	-1.4
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.2	-0.4	-0.1	0.3
Breast Cancer	3.0	7.2	14.8	3.9	-1.9	-1.8
Ovarian Cancer	1.7	2.2	3.1	-0.9	1.6	1.8
Prostate Cancer	0.8	1.2	1.9	-1.4	-0.9	-0.8
Age at First Birth	0.8	1.1	1.8	1.4	0.7	1.0
Bipolar Disorder (2011)	0.3	0.3	0.4	0.7	0.4	0.5
Body Mass Index (BMI) (2010)	1.1	1.5	2.4	-1.5	-1.0	-1.0
Coronary Artery Disease (CAD)	1.3	1.5	4.0	2.0	0.6	0.5
Crohns Disease (2012)	3.3	5.3	9.7	-0.5	-2.5	-3.1
Mean Putamen Volume	0.2	0.2	0.4	0.6	-0.4	-0.4
Fasting Glucose	1.4	1.7	2.7	0.1	-1.6	-1.6
HbA1C	1.6	1.8	2.7	1.1	-1.2	-1.6
HDL Cholesterol	0.5	0.8	0.9	-1.0	-0.9	-0.9
LDL Cholesterol	1.4	2.2	6.5	2.5	-0.2	0.0
Lupus	0.5	0.7	1.5	1.2	-0.4	-0.6
Neuroticism (2016)	0.9	1.3	2.0	0.2	-1.4	-1.4
Primary Biliary Cirrhosis	0.6	0.8	1.4	0.6	-0.9	-1.2
Rheumatoid Arthritis	0.4	0.6	1.6	-1.3	-0.1	-0.2
Schizophrenia (2014)	0.2	0.5	0.7	-0.4	-0.8	-0.8
Triglycerides	0.4	0.6	1.7	1.3	-0.2	-0.3
Type 2 Diabetes (T2D) (2012)	1.3	1.4	2.3	0.4	1.4	1.5
Ulcerative Colitis	0.1	0.2	0.4	0.4	-0.2	-0.6
Blood Eosinophil Count	2.6	20.3	22.3	4.1	4.7	4.7
Blood Platelet Count	0.9	10.3	18.8	0.9	3.4	4.3
Blood Red Count	1.7	16.7	29.4	-1.1	4.4	5.4
Blood White Count	12.9	95.9	163.8	1.7	11.0	12.8
Heel T-Score	0.3	2.4	5.4	2.3	1.0	0.9
BMI	0.4	2.6	4.8	-0.5	-1.6	-2.2
Height	0.6	11.5	16.1	-2.0	4.0	3.8
Waist Hip Ratio (WHR)	0.4	1.9	2.9	0.7	1.5	1.7
Systolic Blood Pressure	0.7	3.7	7.5	0.5	-1.8	-2.7
Smoking Status	0.6	1.4	3.3	-1.8	-0.8	-0.5
Allergy or Eczema	1.7	4.5	6.5	0.9	2.5	2.5
Cardiovascular Disease	0.4	1.5	1.9	0.8	-1.4	-1.4
Hypothyroidism (self reported)	0.2	0.4	0.5	-0.7	-0.5	-0.7
Respiratory disease	0.0	0.1	0.1	0.0	-0.1	-0.4
Type 2 Diabetes (T2D) (2018)	1.0	1.8	4.2	2.1	0.6	0.9
Lung FEV1/FVC ratio	0.3	1.4	2.9	0.3	-1.0	-1.7
Lung FVC	0.6	2.8	4.2	-1.2	1.7	2.0
Neuroticism	2.0	4.8	6.8	1.4	-2.4	-2.6
Chronotype (morning person)	1.0	2.4	4.2	0.9	2.1	1.5
Hair Pigment	0.1	3.9	6.4	-2.5	1.6	1.6
Tanning	0.0	0.2	0.4	0.2	-0.2	-0.6
Hand grip strength (left)	0.6	1.5	4.6	-2.1	-0.1	0.2
Number of treatments/medications taken	1.6	2.8	8.4	2.9	0.4	0.1
Average weekly spirits intake	0.1	0.1	0.1	0.2	0.4	0.4
Sensitivity / hurt feelings	5.0	8.5	13.1	-0.7	-3.4	-3.6
Frequency of depressed mood in last 2 weeks	4.1	5.8	9.2	-0.1	-3.0	-2.9
Hearing difficulty/problems: Yes	1.0	1.5	2.3	0.5	1.5	1.4
Relative age of first facial hair	0.8	1.7	2.2	1.3	1.0	1.5
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	1.1	0.8	-0.7	-1.0
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.1	0.3	0.1	-0.2
Ever had hysterectomy (womb removed)	0.5	0.6	1.2	-0.1	-0.7	-1.1
Systolic blood pressure, automated reading	1.4	4.0	7.7	0.0	-2.1	-2.8
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	2.2	1.0	1.1	1.5
Angina	1.4	1.9	1.9	1.4	1.4	1.3
Medication for hormone replacement therapy	0.1	0.2	0.2	-0.1	-0.5	-0.5
Vitamin and mineral supplements	0.7	0.9	1.6	-1.3	0.8	0.7
Supplements: Zinc	1.6	1.8	5.3	2.3	0.1	0.1
Medication: Co-codamol	0.3	0.3	0.5	0.2	-0.6	-0.7
Medication: Metformin	1.7	2.4	3.1	1.8	1.4	1.5
Diabetes (father)	3.1	3.8	4.6	2.2	1.7	2.0
Diabetes (mother)	0.0	0.0	0.1	0.1	0.2	0.2
Severe depression (siblings)	2.1	2.3	4.0	0.3	-2.0	-1.7
Pack years adult smoking proportion	1.9	2.9	7.6	-2.8	-0.6	-0.9
Impedance of leg (right)	0.8	3.9	7.3	1.1	1.8	2.7
Leg fat-free mass (left)	0.0	0.1	0.3	-0.6	0.2	-0.2
Trunk fat percentage	0.0	0.0	0.0	-0.1	0.2	0.2
Hand grip strength (right)	0.2	0.6	1.2	-1.1	0.4	0.7
Townsend deprivation index at recruitment	0.4	0.6	1.6	-1.2	-0.1	-0.5
Current tobacco smoking	2.3	3.8	5.4	-1.0	-2.3	-2.2
Average weekly fortified wine intake	1.0	1.2	1.8	-1.3	0.9	1.0
Maternal smoking around birth	0.4	0.6	0.9	-0.5	-0.8	-1.0
Fed-up feelings	0.3	0.6	0.9	0.7	-0.9	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	3.1	4.1	6.6	-0.2	-2.4	-2.6
Relative age voice broke	0.7	1.1	2.2	1.5	0.5	0.9
Taking other prescription medications	1.3	2.0	5.5	2.4	-0.2	-0.6
Age when periods started (menarche)	0.3	0.8	1.0	-1.0	0.8	0.9
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	2.2	1.5	-1.2	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.0	1.0	-0.8	-0.6
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.1	-1.1	0.2	0.1
Qualifications: CSEs or equivalent	0.2	0.2	0.4	-0.7	-0.4	-0.3
Serious illness, injury or assault to yourself	1.1	1.3	2.2	-1.5	0.9	0.9
High blood pressure	0.4	1.3	2.8	1.7	-0.6	-0.8
Hayfever, allergic rhinitis or eczema	1.2	2.7	3.9	0.9	1.9	2.0
Multivitamins +/- minerals	0.5	0.6	0.8	0.9	-0.8	-0.6
Stomach or abdominal pain in last month	0.1	0.1	0.2	0.4	-0.0	-0.2
Supplements: Glucosamine	0.5	0.6	0.8	0.8	0.6	0.9
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.4	0.7	0.4	0.6
Medication: Atenolol	1.1	1.3	2.8	-0.1	1.7	1.1
Medication: Levothyroxine sodium	0.2	0.3	0.5	-0.5	0.7	0.3
Sitting height	0.4	3.1	8.6	-2.9	-0.4	-0.8
Chronic bronchitis/emphysema (father)	5.8	6.8	10.3	0.3	-3.2	-3.2
High blood pressure (mother)	4.1	5.8	7.9	1.4	-2.8	-2.8
Body mass index (BMI)	0.3	1.1	2.1	-0.2	-1.1	-1.4
Impedance of leg (left)	0.6	3.0	6.1	0.5	1.6	2.5
Leg predicted mass (left)	0.0	0.1	0.3	-0.5	0.2	-0.2
Trunk fat mass	0.0	0.1	0.2	-0.1	0.5	0.4
Waist circumference	0.0	0.1	0.2	0.5	0.1	0.0
Number of incorrect matches in round	0.8	1.4	4.0	2.0	0.3	0.3
Past tobacco smoking	0.3	0.5	0.8	0.7	-0.3	-0.9
Alcohol usually taken with meals	0.4	0.7	2.0	1.4	-0.3	0.1
Nervous feelings	0.9	1.6	3.0	0.1	-1.3	-1.7
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.1	3.5	-0.2	-1.7	-1.9
Hearing difficulty/problems with background noise	2.7	4.4	4.9	1.9	2.1	2.2
Hair/balding pattern: Pattern 2	0.6	0.7	1.3	-0.5	0.8	1.1
Had menopause	0.3	0.3	0.5	0.4	0.7	0.5
Had other major operations	0.9	1.1	1.7	0.3	1.2	1.3
Forced vital capacity (FVC)	1.6	6.3	8.8	-1.7	2.7	3.0
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.6	-0.0	-0.8	-0.7
Ever unenthusiastic/disinterested for a whole week	2.0	2.5	3.9	-0.0	-2.0	-1.9
Qualifications: None of the above	0.0	0.1	0.1	-0.3	0.4	-0.2
Financial difficulties in last 2 years	0.6	0.7	1.2	-0.4	-1.1	-0.9
Mouth/teeth dental problems	2.7	4.2	5.5	2.3	1.5	2.2
Heart attack	1.9	2.4	4.3	2.1	1.3	1.1
Allergy	0.9	2.1	2.5	-1.2	-1.6	-1.6
Pain all over the body in last month	0.0	0.0	0.0	0.2	0.0	0.1
Diabetes (self-reported)	1.1	1.7	3.2	1.8	1.0	0.9
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.6	0.3	0.5	0.8
Medication: Ramipril	1.0	1.2	1.5	1.2	1.1	1.0
Medication: Simvastatin	1.4	2.1	4.8	2.2	0.8	0.9
Fluid intelligence score	0.2	0.5	1.0	-0.2	-1.0	-0.5
Illnesses of siblings	0.1	0.2	0.3	-0.5	0.2	0.4
Neuroticism score	2.8	5.9	8.2	1.4	-2.7	-2.9
Weight	0.0	0.1	0.4	-0.6	0.1	-0.2
Impedance of arm (right)	0.6	2.6	5.0	0.9	1.4	2.2
Arm fat percentage (right)	0.0	0.0	0.1	0.3	-0.1	-0.1
Trunk fat-free mass	0.0	0.1	0.3	-0.3	0.5	0.2
Hip circumference	0.1	0.2	0.3	-0.5	0.4	0.5
Time employed in main current job	1.0	1.1	2.0	-0.6	-1.0	-1.4
Alcohol intake versus 10 years previously	0.1	0.2	0.3	0.2	-0.5	-0.5
Father’s age at death	0.3	0.4	0.7	0.5	0.6	0.8
Worrier / anxious feelings	1.2	2.2	3.3	0.1	-1.8	-1.8
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	2.4	1.2	-1.6	-1.2
Falls in the last year	1.2	1.6	4.6	2.1	-0.3	-0.2
Hair/balding pattern: Pattern 3	0.0	0.1	0.1	0.3	0.2	-0.2
Number of live births	0.1	0.2	0.3	0.5	0.6	0.3
Forced expiratory volume in 1-second (FEV1)	1.0	3.2	4.7	-1.0	2.0	2.2
Pulse rate	0.3	0.5	0.7	-0.8	0.4	0.8
Happiness	1.6	2.0	2.2	-1.2	-1.4	-1.5
Noisy workplace	0.1	0.2	0.3	0.1	-0.5	-0.4
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.5	0.1	-0.7	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.3	-0.6	-0.2	-0.2
Mouth/teeth dental problems: Dentures	1.5	2.6	5.6	-2.4	-0.6	-1.4
Asthma	0.3	0.5	0.9	0.9	0.7	0.4
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.6	4.7	2.2	0.1	0.4
Medication: Cholesterol lowering	1.9	3.0	5.0	2.2	1.4	1.4
Depression (self-reported)	3.6	4.3	6.2	-1.1	-2.4	-2.5
Medication: Lansoprazole	0.3	0.4	0.4	-0.6	0.6	0.6
Prospective memory result	0.7	0.9	1.5	0.1	1.2	1.1
Lung cancer (father)	0.6	0.7	1.1	-0.6	-0.9	-1.0
Illnesses of mother	1.8	2.2	6.3	-2.5	0.6	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.5	8.6	-0.7	2.7	2.9
Pulse wave Arterial Stiffness index	0.9	1.0	1.1	1.0	1.1	1.0
Impedance of arm (left)	0.4	1.8	3.7	0.7	1.1	1.9
Arm fat mass (right)	0.0	0.1	0.1	-0.1	-0.2	-0.4
Trunk predicted mass	0.0	0.2	0.4	-0.3	0.6	0.3
Standing height	0.5	4.6	6.9	-0.9	2.5	2.6
Length of working week for main job	0.1	0.1	0.1	0.2	0.1	0.4
Exposure to tobacco smoke at home	1.2	1.3	4.0	-2.0	-0.1	-0.2
Breastfed as a baby	1.0	1.3	2.1	0.2	-1.4	-1.3
Tense / ‘highly strung’	0.6	1.0	1.7	0.2	-1.1	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	2.2	3.4	5.3	0.9	-2.1	-2.3
Hair/balding pattern: Pattern 4	0.2	0.4	0.6	-0.7	0.8	0.4
Birth weight of first child	0.8	1.5	2.7	-0.1	-1.3	-1.7
Peak expiratory flow (PEF)	2.5	5.8	9.4	0.4	2.8	3.1
Pulse wave reflection index	1.6	2.0	3.6	1.9	1.1	1.2
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.5	0.7	0.4	0.2
Loud music exposure frequency	1.0	1.1	1.5	1.0	-0.9	-1.2
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	3.7	0.5	1.1	1.9
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.2	-0.4	0.4	0.4
Blood clot in the leg (DVT)	1.1	1.5	2.2	-0.1	1.5	1.5
Medication: Paracetamol	1.5	2.5	2.9	1.7	-1.4	-1.6
Headache pain in last month	2.1	3.5	7.9	2.8	-1.1	-1.2
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	3.2	-1.8	-1.1	-1.0
Glaucoma (self-reported)	1.9	2.2	4.0	2.0	1.2	1.1
Gout (self-reported)	1.6	2.2	4.3	-2.1	-1.0	-1.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.3	0.5	0.3	0.1
Medication: Amlodipine	0.3	0.4	0.6	0.8	-0.4	-0.6
Medication: Ventolin 100micrograms inhaler	0.6	0.8	0.9	0.9	-0.9	-0.9
Birth weight	0.0	0.1	0.1	-0.2	0.3	0.3
Chronic bronchitis/emphysema (mother)	5.2	6.0	9.5	-0.5	-2.9	-3.1
High blood pressure (siblings)	0.0	0.0	0.1	0.3	0.1	0.1
Forced vital capacity (FVC), Best measure	2.0	7.2	11.4	-1.1	3.0	3.4
Body fat percentage	0.0	0.0	0.1	0.1	0.2	0.2
Leg fat percentage (right)	0.1	0.3	0.5	0.3	0.6	0.7
Arm fat-free mass (right)	0.0	0.2	0.3	-0.6	0.3	-0.2
Exposure to tobacco smoke outside home	4.2	5.6	7.4	-1.6	-2.6	-2.7
Comparative body size at age 10	0.1	0.4	1.0	1.0	-0.3	-0.4
Number of full brothers	0.0	0.1	0.1	0.3	-0.2	-0.1
Worry too long after embarrassment	0.6	1.1	1.7	0.8	-1.3	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	3.3	4.3	5.3	1.6	-2.3	-2.3
Wheeze or whistling in the chest in last year	0.2	0.3	0.9	-1.0	0.1	-0.1
Number of children fathered	0.5	0.6	1.0	-0.1	0.9	1.0
Reason for reducing amount of alcohol drunk: Health precaution	3.6	4.2	5.1	2.0	1.9	2.3
Age at first live birth	1.0	1.7	1.9	1.2	1.4	1.3
Pulse wave peak to peak time	0.6	0.7	0.9	-1.0	-0.8	-0.7
Health satisfaction	0.1	0.2	0.3	-0.0	-0.5	-0.5
Shortness of breath walking on level ground	0.4	0.5	0.9	-0.0	1.0	0.7
Qualifications: College or University degree	0.1	0.3	0.9	0.9	-0.3	0.1
Eye problems/disorders: None of the above	0.6	0.7	1.2	0.1	-1.1	-0.9
Mouth/teeth dental problems: Loose teeth	0.4	0.4	0.7	-0.4	-0.7	-0.8
Emphysema/chronic bronchitis	1.0	1.2	3.3	-1.8	0.5	0.0
Medication for pain relief, constipation, heartburn	0.9	1.6	4.7	-2.2	-0.3	-0.2
Neck or shoulder pain in last month	0.9	1.3	2.4	1.5	0.7	1.0
Medication: Blood pressure	0.4	0.6	0.9	0.8	0.9	0.6
Angina (self-reported)	1.3	1.7	3.2	1.8	1.0	1.0
Migraine (self-reported)	2.2	2.7	4.5	0.1	-2.1	-1.9
Medication: Ibuprofen	1.1	1.3	3.4	1.8	0.4	0.7
Medication: Allopurinol	0.2	0.2	0.7	-0.8	0.0	-0.1
Medication: Omeprazole	0.5	0.6	1.0	0.0	1.0	0.9
Medication: Seretide 50 evohaler	2.3	2.7	3.5	-1.4	-1.6	-1.9
Mean time to correctly identify matches	0.5	0.9	1.6	0.7	-0.7	-1.2
Heart disease (mother)	2.5	3.0	5.1	2.3	1.3	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.0	-0.1	-0.2	-0.1
Whole body fat mass	0.0	0.0	0.1	-0.1	0.3	0.2
Leg fat mass (right)	0.0	0.1	0.2	0.2	0.4	0.3
Arm predicted mass (right)	0.0	0.2	0.4	-0.5	-0.2	-0.6
Pulse rate, automated reading	0.4	1.2	2.4	-1.6	-0.9	-0.6
Alcohol intake frequency.	3.6	8.3	9.9	-2.9	-2.5	-3.1
Comparative height size at age 10	1.3	7.0	11.5	1.0	3.4	3.0
Number of full sisters	0.5	0.6	1.1	0.1	-1.1	-0.9
Suffer from ‘nerves’	0.6	0.9	1.2	1.1	-0.8	-0.9
Overall health rating	0.1	0.3	0.8	-0.1	-0.3	-0.9
Chest pain or discomfort	0.5	0.7	0.9	0.9	-0.9	-0.6
Had major operations	0.0	0.0	0.1	0.2	-0.1	0.0
Age at last live birth	0.7	1.0	1.8	0.4	1.3	1.1
Family relationship satisfaction	0.2	0.2	0.5	-0.7	0.1	0.1
Leg pain on walking	0.4	0.5	1.3	1.2	-0.1	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.6	-1.2	0.2	0.1
Commuting to job workplace: Car/motor vehicle	1.6	1.8	2.8	-0.1	1.7	1.6
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.6	0.7	0.8	0.6
Medication: Aspirin	3.4	4.4	4.8	2.1	2.2	2.0
Supplements: Vitamin C	1.1	1.3	3.8	1.9	-0.1	0.1
Knee pain experienced in last month	1.1	1.8	2.6	0.7	-1.6	-1.5
Hypertension (Self-reported)	0.4	1.0	2.8	1.7	-0.2	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.3	2.7	3.8	0.7	1.9	1.9
Illnesses of father: Heart disease	2.5	3.4	4.6	2.1	1.6	1.8
Illnesses of siblings: Diabetes	0.0	0.0	0.0	0.1	0.1	0.1
Smoking status: Previous	0.3	0.5	1.0	-0.2	0.7	1.0
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.7	4.2	-1.8	1.9	2.0
Whole body fat-free mass	0.0	0.2	0.4	-0.6	0.3	-0.1
Leg fat-free mass (right)	0.1	0.4	1.2	-1.1	0.1	-0.4
Arm fat percentage (left)	0.0	0.1	0.1	0.2	-0.2	-0.3
Average weekly red wine intake	1.3	1.9	4.2	2.1	0.8	0.8
Handedness (chirality/laterality): Left-handed	1.2	1.5	2.8	-1.7	-1.1	-0.8
Mood swings	2.4	4.3	5.6	1.4	-2.4	-2.3
Loneliness, isolation	0.3	0.5	1.3	1.1	-0.2	-0.2
Long-standing illness, disability or infirmity	0.9	1.4	2.8	0.4	-1.1	-1.7
Ever had bowel cancer screening	0.2	0.2	0.4	0.6	-0.2	-0.6
Diabetes diagnosed by doctor	1.1	1.8	2.5	0.8	1.5	1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.1	1.5	0.4	0.6
Friendships satisfaction	0.5	0.6	0.7	0.7	-0.9	-0.7
Qualifications: nursing, teaching	0.1	0.2	0.4	0.7	-0.1	0.1
Commuting to job workplace: Walk	2.6	2.8	5.9	2.4	-1.2	-1.0
Eye problems/disorders: Cataract	1.7	2.0	5.3	-2.3	0.6	0.5
Mouth/teeth dental problems: Mouth ulcers	5.5	8.7	12.9	-1.1	-3.5	-3.6
Medication for cholesterol	0.5	0.7	1.5	-0.4	-1.2	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.7	3.2	5.2	0.4	2.3	2.0
Back pain experienced in last month	0.8	1.2	2.1	0.2	1.4	1.2
Mineral and other dietary supplements	0.2	0.3	0.5	-0.7	0.5	0.4
Breast cancer (self-reported)	0.0	0.0	0.1	0.3	0.1	0.2
Asthma (self-reported)	0.3	0.5	0.8	0.9	0.7	0.5
Osteoporosis (self-reported)	1.1	1.4	2.4	0.2	-1.3	-1.5
Osteoarthritis (self-reported)	0.7	0.9	1.9	1.4	-0.6	-0.7
Medication: Aspirin	4.0	5.2	6.3	1.9	2.5	2.4
Medication: Gliclazide	2.3	2.6	7.1	2.7	0.6	0.7
Illnesses of father: None of the above (group 1)	3.2	3.9	9.4	-3.1	-1.0	-1.2
Smoking status: Current	1.9	3.0	4.2	-1.1	-2.1	-1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.4	3.4	-1.1	1.6	1.8
Whole body water mass	0.0	0.1	0.3	-0.5	0.3	-0.1
Leg predicted mass (right)	0.1	0.5	1.4	-1.2	0.0	-0.5
Arm fat mass (left)	0.0	0.0	0.1	-0.1	-0.1	-0.3
Number of self-reported non-cancer illnesses	1.2	2.0	6.0	2.5	0.3	0.1
Average weekly champagne plus white wine intake	1.4	1.9	3.1	0.8	1.3	1.8
Miserableness	4.3	7.4	9.4	3.1	-2.5	-2.6
Guilty feelings	0.3	0.4	0.7	0.4	-0.8	-0.6
Wears glasses or contact lenses	0.3	0.3	0.7	0.8	0.3	0.4
Ever taken oral contraceptive pill	0.8	0.9	1.8	-1.3	0.5	0.8
Hearing aid user	1.2	1.3	2.3	-0.2	1.5	1.3
Mother’s age at death	2.3	2.9	4.8	2.2	1.1	1.6
Financial situation satisfaction	0.8	1.0	1.4	-1.2	-1.1	-0.7
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.2	0.1	0.9	1.1
Commuting to job workplace: Public transport	2.1	2.5	3.6	0.7	-1.9	-1.9
Eye problems/disorders: Glaucoma	2.2	2.6	2.8	1.5	1.7	1.6
Medication: Blood pressure	0.4	0.8	2.2	1.5	-0.1	-0.4
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.4	1.2	-0.4	-0.3
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.1	1.4	-0.5	-0.5
High cholesterol (Self-reported)	0.1	0.1	0.4	0.6	-0.0	0.2
Medication: Bendroflumethiazide	0.1	0.1	0.3	-0.5	-0.2	-0.3
Medication: Paracetamol	1.7	2.7	3.1	1.7	-1.5	-1.8
Medication: Lisinopril	1.5	2.0	5.9	2.4	0.2	0.2
Medication: Atorvastatin	4.5	5.6	7.8	-1.4	2.8	2.7
Illnesses of father: High blood pressure	0.7	0.9	1.4	1.2	0.8	0.8
Alcohol drinker status: Never	2.3	2.7	4.6	0.1	-1.9	-2.1
Ever smoked	0.1	0.1	0.4	-0.3	-0.6	-0.0
Basal metabolic rate	0.0	0.1	0.3	-0.6	0.3	-0.1
Leg fat percentage (left)	0.1	0.2	0.3	-0.1	0.6	0.6
Arm fat-free mass (left)	0.0	0.1	0.2	-0.4	0.4	0.1
Number of operations (self-reported)	0.1	0.2	0.2	0.4	0.4	0.5
Average weekly beer plus cider intake	1.4	2.0	2.7	-1.7	1.4	1.2
Irritability	1.9	3.2	3.4	1.8	-1.7	-1.8
Risk taking	1.7	2.4	6.9	-2.6	-0.3	-0.6
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.6	0.8	0.0	0.1
Fractured/broken bones in last 5 years	0.2	0.2	0.5	-0.7	0.1	0.4
Age started oral contraceptive pill	1.7	2.2	3.3	0.8	1.8	1.6
Diastolic blood pressure, automated reading	0.5	1.6	3.1	-0.3	-1.3	-1.8
Ever depressed for a whole week	4.4	5.4	7.6	-1.0	-2.7	-2.8
Unable to work because of sickness or disability	1.5	2.0	3.1	-0.9	-1.4	-1.8
Commuting to job workplace: Cycle	2.0	2.4	3.1	1.1	-1.7	-1.8
Myopia	0.3	0.5	1.5	1.2	-0.1	0.1
Vascular/heart problems diagnosed by doctor	0.6	1.7	4.8	-2.2	0.2	0.4
Cholesterol lowering medication	1.4	2.0	3.2	-0.1	1.8	1.7
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.3	-0.1	0.5	0.6
Pain experienced in last month	1.8	3.1	7.7	-2.8	0.9	0.8
Supplements: Calcium	0.0	0.0	0.0	0.2	-0.1	-0.1
Basal cell carcinoma (self-reported)	0.7	0.8	1.0	0.8	0.8	1.0
Heart attack/myocardial infarction (self-reported)	1.8	2.3	4.4	2.1	1.2	1.0
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	2.6	-0.0	1.6	1.6
Heart disease (siblings)	0.5	0.7	2.0	1.4	0.2	0.0
Alcohol drinker status: Previous	0.2	0.2	0.3	-0.4	-0.4	-0.5
Pack years of smoking	1.5	2.2	6.1	-2.5	-0.3	-0.6
Impedance of whole body	0.5	2.4	5.0	0.5	1.4	2.2
Leg fat mass (left)	0.0	0.1	0.2	-0.1	0.4	0.3
Arm predicted mass (left)	0.0	0.2	0.4	-0.7	0.3	-0.1