Hub : Genes

DHX40

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.1400	0.0540	9.5e-06	0.103	NA	0.064	NA	0.067	2.4e-07	NA	4.4e-05	NA	3.1e-05
2	GTEx	Lung	0.1096	0.0442	8.9e-05	0.042	NA	0.085	NA	0.086	3.8e-04	NA	4.7e-07	NA	4.1e-07
3	GTEx	Skin Not Sun Exposed Suprapubic	0.1590	0.0740	5.7e-04	0.050	NA	0.068	NA	0.077	9.5e-04	NA	1.4e-04	NA	4.9e-05
4	GTEx	Skin Sun Exposed Lower leg	0.0700	0.0370	2.6e-03	0.000	NA	0.001	NA	-0.002	3.3e-01	NA	2.3e-01	NA	5.5e-01
5	GTEx	Testis	0.2450	0.0650	2.7e-10	0.127	NA	0.162	NA	0.177	2.8e-06	NA	1.1e-07	NA	2.6e-08
6	GTEx	Thyroid	0.0660	0.0300	1.3e-03	0.041	NA	0.015	NA	0.032	3.9e-04	NA	2.2e-02	NA	1.7e-03
7	YFS	Blood	0.0111	0.0061	3.3e-03	0.006	0.005	0.005	0.005	0.007	2.8e-03	0.005	5.1e-03	0.005	1.6e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.1	0.1	0.4	0.1	-0.2	-0.5	-0.5	0.1	0.0	-0.6
Bipolar Disorder or Schizophrenia	0.1	0.3	1.6	-0.3	-1.3	-0.2	-0.3	0.1	0.1	-0.7
Depressed Affect (Nagel 2018)	0.9	1.9	4.5	0.2	1.9	0.9	2.1	-0.1	0.5	-2.0
Depression (Nagel 2018)	0.7	1.0	4.3	-0.3	1.1	0.2	2.1	-0.8	-0.3	-1.0
Intelligence (Savage-Jansen 2018)	0.9	2.9	7.0	-1.0	-0.6	0.1	2.5	-1.6	-1.6	2.6
Neuroticism (Nagel 2018)	1.7	3.9	10.1	1.0	2.5	1.6	3.2	0.8	1.5	-2.2
Schizophrenia (2018)	0.2	0.4	2.1	-0.5	-1.5	0.1	-0.0	0.0	0.2	-0.4
Schizophrenia vs Biploar Disorder	0.7	0.9	3.1	-1.1	-0.4	0.1	1.8	-0.7	-0.6	1.0
Worry (Nagel 2018)	2.2	4.5	7.4	1.5	2.5	1.7	2.7	1.8	2.3	-2.2
Alzheimer’s Disease (in mother)	0.2	0.3	0.5	0.7	0.5	0.0	0.1	0.6	0.7	0.6
Alzheimer’s Disease (in father)	1.7	1.9	3.8	-1.7	-0.8	-0.9	-0.5	-1.9	-1.6	1.4
Alzheimer’s Disease (including proxy)	0.8	1.1	1.9	-1.1	-0.6	-1.4	-0.9	-1.0	-0.9	1.4
Crohns Disease (2017)	3.3	7.2	15.2	2.0	1.5	3.0	3.1	2.3	2.3	-3.9
Irritable Bowel Disease (IBD)	1.7	4.1	11.8	1.3	1.1	2.2	2.0	1.6	1.7	-3.4
Ulcerative Colitis (UC)	0.2	0.3	2.2	-0.1	0.1	0.3	-0.0	0.0	0.1	-1.5
Major Depression (MDD)	0.6	0.7	1.1	-0.8	-1.0	-0.3	-0.5	-1.0	-0.9	0.9
Reaction Time	0.4	0.7	2.0	-0.9	1.2	-0.6	-0.1	-0.3	-0.4	-1.4
Verbal and Numeric Reasoning (VNR)	0.4	0.9	4.8	0.1	-0.0	0.7	2.2	-0.2	-0.2	0.8
Breast Cancer	0.4	1.0	3.7	-0.9	0.0	0.2	-0.4	-1.9	-1.2	-1.1
Ovarian Cancer	0.3	0.4	1.1	-0.2	-0.6	-0.9	0.6	-0.0	-0.4	1.0
Prostate Cancer	3.9	5.5	10.8	3.3	1.0	3.0	0.5	2.7	2.9	-1.4
Age at First Birth	0.8	1.2	1.8	-1.2	0.7	-1.3	-0.5	-1.3	-1.2	1.2
Bipolar Disorder (2011)	1.5	1.5	2.4	-1.3	-1.5	-0.8	-1.6	-1.3	-1.1	0.7
Body Mass Index (BMI) (2010)	0.4	0.6	2.7	0.1	0.6	0.9	1.7	0.4	0.2	-0.2
Coronary Artery Disease (CAD)	1.0	1.2	4.8	-0.5	-0.4	-1.3	-2.2	-1.0	-0.7	-0.2
Crohns Disease (2012)	3.3	5.3	13.8	1.5	1.3	2.1	3.7	1.9	1.6	-3.0
Mean Putamen Volume	1.2	1.4	1.8	1.2	1.2	1.1	1.2	1.4	1.2	-1.0
Fasting Glucose	0.2	0.3	0.7	-0.3	-0.2	0.7	0.8	-0.5	-0.6	0.1
HbA1C	0.5	0.6	2.5	-0.4	-0.5	-0.1	1.6	-0.2	-0.1	-1.1
HDL Cholesterol	0.5	0.8	1.3	1.0	1.0	1.2	0.8	0.9	0.9	-0.6
LDL Cholesterol	1.8	2.9	5.3	-2.3	-0.3	-1.6	-0.4	-2.2	-2.3	1.4
Lupus	0.2	0.3	1.8	0.2	0.5	-0.0	-0.3	0.2	0.1	-1.3
Neuroticism (2016)	0.6	0.8	2.1	0.1	1.4	0.9	1.0	0.3	0.5	-1.2
Primary Biliary Cirrhosis	0.5	0.7	3.1	0.5	0.3	0.1	-0.6	0.6	0.6	-1.8
Rheumatoid Arthritis	0.2	0.2	0.7	0.6	-0.9	0.4	0.4	0.4	0.2	0.2
Schizophrenia (2014)	0.2	0.4	0.9	-0.9	-1.0	0.2	-0.6	-0.4	-0.2	-0.7
Triglycerides	0.1	0.1	0.3	-0.2	0.5	0.3	0.1	-0.3	-0.1	-0.4
Type 2 Diabetes (T2D) (2012)	1.4	1.7	4.5	-0.4	-2.1	-0.8	-1.5	-1.1	-0.9	1.4
Ulcerative Colitis	0.5	0.7	2.6	0.3	1.1	0.1	0.3	0.7	0.7	-1.6
Blood Eosinophil Count	1.4	10.6	25.4	-2.8	-2.7	-5.0	-2.1	-3.7	-3.0	2.7
Blood Platelet Count	5.3	61.3	93.3	-8.8	-7.2	-7.7	-0.6	-8.6	-8.6	9.7
Blood Red Count	0.3	2.7	15.8	0.2	-0.7	-1.1	-1.3	-0.2	-0.0	4.0
Blood White Count	15.0	111.5	210.2	-9.1	-10.3	-11.6	-8.5	-9.7	-9.0	14.5
Heel T-Score	0.2	1.7	4.8	-0.9	-0.9	-1.4	-2.2	-1.2	-1.3	0.6
BMI	0.4	2.3	4.5	1.9	0.3	1.3	1.3	1.6	1.4	-2.1
Height	0.4	8.2	13.9	3.2	3.4	0.8	2.3	3.6	3.7	-1.5
Waist Hip Ratio (WHR)	0.5	2.1	4.5	-1.4	-2.1	-1.6	-0.4	-1.3	-1.1	1.7
Systolic Blood Pressure	0.5	2.3	7.9	1.8	0.1	0.6	-1.7	1.1	0.8	-2.8
Smoking Status	0.3	0.8	2.2	-0.6	-0.3	0.3	1.4	-0.7	-0.6	1.5
Allergy or Eczema	1.0	2.6	7.3	-1.1	-1.5	-2.7	-1.4	-1.4	-1.3	1.3
Cardiovascular Disease	0.2	0.6	1.5	1.0	0.1	1.2	-0.4	0.0	0.1	-1.1
Hypothyroidism (self reported)	1.3	3.0	4.6	2.0	2.1	1.2	-0.8	2.0	1.8	-1.8
Respiratory disease	0.7	1.5	2.9	1.7	0.9	0.6	1.0	1.2	1.3	-1.4
Type 2 Diabetes (T2D) (2018)	4.2	7.8	12.1	-2.3	-3.5	-2.7	-2.3	-3.0	-3.0	2.7
Lung FEV1/FVC ratio	0.6	3.0	10.0	0.8	2.0	1.0	1.2	1.4	1.5	-3.2
Lung FVC	0.2	0.8	1.8	0.9	0.7	0.5	0.1	1.0	1.0	1.3
Neuroticism	2.9	7.0	17.1	1.3	3.2	2.4	4.1	1.4	1.9	-2.9
Chronotype (morning person)	0.9	2.0	6.6	-1.3	-0.3	-2.3	-2.6	-0.5	-0.5	0.3
Hair Pigment	0.0	0.4	0.8	-0.5	-0.8	-0.9	-0.7	0.2	-0.1	0.9
Tanning	0.1	0.9	4.1	0.2	1.2	0.0	0.2	0.5	0.7	-2.0
Hand grip strength (left)	0.6	1.7	5.9	1.0	0.2	1.3	2.4	1.2	1.2	0.5
Number of treatments/medications taken	0.8	1.5	2.9	-0.9	-0.0	-1.7	-1.5	-1.6	-1.3	-0.1
Average weekly spirits intake	1.8	2.3	3.3	-1.5	-1.2	-1.8	0.9	-1.4	-1.6	1.8
Sensitivity / hurt feelings	5.0	8.6	16.8	1.7	2.2	3.1	4.1	2.3	2.6	-3.7
Frequency of depressed mood in last 2 weeks	2.3	3.3	11.0	0.7	1.8	2.3	3.3	0.1	0.5	-1.7
Hearing difficulty/problems: Yes	0.6	0.9	2.9	0.7	0.5	-0.5	-1.7	0.4	0.8	-1.1
Relative age of first facial hair	2.3	4.7	7.1	-2.4	-1.5	-2.1	1.3	-2.7	-2.5	2.4
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	1.3	-0.1	0.1	-0.1	-0.2	-0.1	0.0	-1.1
Ever used hormone-replacement therapy (HRT)	1.5	1.9	3.8	1.2	1.9	0.5	-0.7	1.3	1.4	-1.9
Ever had hysterectomy (womb removed)	3.3	3.7	8.0	2.0	1.4	1.4	0.6	2.1	2.2	-2.8
Systolic blood pressure, automated reading	1.1	3.3	10.8	1.9	0.2	1.1	-1.8	1.6	1.3	-3.3
Eye problems/disorders: Diabetes related eye disease	2.3	2.5	4.1	-1.2	-2.0	-1.6	-1.3	-1.6	-1.6	1.6
Angina	2.6	3.4	6.2	-2.1	-0.8	-2.5	-1.1	-2.1	-1.9	1.9
Medication for hormone replacement therapy	0.0	0.0	0.1	-0.3	0.3	0.1	0.0	0.1	-0.1	0.1
Vitamin and mineral supplements	1.2	1.6	3.7	1.9	-0.2	0.7	-0.8	1.7	1.7	-0.8
Supplements: Zinc	0.3	0.3	0.6	-0.4	0.8	-0.5	0.7	-0.5	-0.4	-0.3
Medication: Co-codamol	0.6	0.7	2.2	0.3	0.9	0.0	-1.0	0.5	0.6	-1.5
Medication: Metformin	2.8	4.0	6.8	-1.8	-1.9	-2.6	-1.0	-2.2	-2.2	1.9
Diabetes (father)	10.2	12.6	16.0	-3.5	-4.0	-4.0	-2.8	-3.6	-3.5	3.4
Diabetes (mother)	0.2	0.2	0.7	-0.0	0.1	-0.5	-0.8	-0.4	-0.5	0.3
Severe depression (siblings)	1.6	1.8	5.5	0.8	0.4	2.4	2.3	0.3	0.7	-0.6
Pack years adult smoking proportion	6.4	9.8	12.0	3.4	3.0	2.8	3.1	3.5	3.4	-2.6
Impedance of leg (right)	1.9	9.2	17.2	-3.4	-2.4	-2.5	-1.1	-3.4	-3.2	4.1
Leg fat-free mass (left)	0.3	1.4	2.7	1.6	0.0	0.4	1.4	1.4	1.3	-1.2
Trunk fat percentage	0.0	0.2	0.5	0.4	-0.7	-0.1	0.6	0.2	0.0	-0.4
Hand grip strength (right)	0.5	1.3	5.6	0.6	-0.3	0.6	2.4	0.4	0.5	1.4
Townsend deprivation index at recruitment	3.1	4.4	7.1	2.7	1.1	1.6	0.1	2.5	2.7	-2.6
Current tobacco smoking	0.4	0.6	2.7	-0.4	-0.3	0.9	1.6	-0.4	-0.4	-0.5
Average weekly fortified wine intake	0.9	1.1	2.4	-0.9	-1.2	-1.3	0.1	-0.6	-0.9	1.5
Maternal smoking around birth	0.3	0.4	1.2	0.3	0.5	0.2	1.1	0.4	0.3	-0.9
Fed-up feelings	0.3	0.5	2.0	-0.5	0.7	0.0	1.4	-0.8	-0.4	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	5.4	0.1	1.0	1.0	2.3	0.1	0.4	-1.9
Relative age voice broke	4.9	7.5	10.4	-3.1	-3.1	-2.4	0.9	-3.2	-3.0	2.7
Taking other prescription medications	0.7	1.0	3.8	0.5	1.5	-0.3	-0.7	0.0	0.6	-1.9
Age when periods started (menarche)	0.1	0.2	1.0	-0.1	-0.3	-0.5	-0.1	-0.0	-0.0	1.0
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.9	0.4	0.7	0.7	-0.1	-0.1	0.3	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.8	-0.9	0.6	-0.3	-0.7	-0.7	-0.9	0.1
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.1	0.8	0.5	0.4	-0.8	1.0	1.1	-1.0
Qualifications: CSEs or equivalent	0.1	0.1	0.3	-0.1	-0.2	0.6	-0.2	0.0	-0.0	0.2
Serious illness, injury or assault to yourself	1.0	1.2	2.5	1.6	0.5	0.5	1.3	1.4	1.4	-0.4
High blood pressure	0.3	0.9	2.1	1.1	0.4	0.6	-1.3	0.3	0.5	-1.4
Hayfever, allergic rhinitis or eczema	0.8	1.7	3.7	-1.1	-1.3	-1.9	-0.4	-1.4	-1.2	1.4
Multivitamins +/- minerals	0.5	0.7	1.8	-0.9	0.6	0.4	1.3	-0.8	-0.8	0.3
Stomach or abdominal pain in last month	0.3	0.4	0.9	-0.8	-0.7	-0.9	0.3	-0.7	-0.4	-0.1
Supplements: Glucosamine	1.8	2.4	3.2	-1.8	-1.4	-1.3	1.0	-1.8	-1.8	1.5
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.5	-0.1	-0.7	0.1	-0.6	-0.7	-0.3	0.1
Medication: Atenolol	0.5	0.7	1.4	0.6	1.1	-1.2	-0.2	0.8	0.5	-0.8
Medication: Levothyroxine sodium	0.5	0.8	1.4	1.0	1.0	-0.4	-1.2	0.8	0.8	-0.9
Sitting height	1.6	11.7	17.9	4.2	1.9	3.2	3.4	4.0	3.8	-2.9
Chronic bronchitis/emphysema (father)	2.2	2.6	4.9	1.2	0.9	2.2	2.2	0.9	0.9	-2.0
High blood pressure (mother)	0.7	1.0	3.7	0.3	0.8	1.5	0.6	-0.0	0.3	-1.9
Body mass index (BMI)	0.1	0.4	1.4	0.8	-0.8	0.2	0.1	0.5	0.3	-1.2
Impedance of leg (left)	1.0	5.1	11.4	-2.6	-1.8	-1.8	-0.3	-2.4	-2.3	3.4
Leg predicted mass (left)	0.3	1.3	2.6	1.6	0.0	0.4	1.4	1.3	1.2	-1.2
Trunk fat mass	0.1	0.2	0.8	0.3	-0.9	-0.5	0.6	0.1	-0.1	-0.1
Waist circumference	0.2	0.7	2.9	-0.3	-1.7	-0.7	0.0	-0.8	-0.8	0.4
Number of incorrect matches in round	1.8	3.0	3.8	-2.0	-1.9	-1.9	-1.7	-1.8	-1.8	0.5
Past tobacco smoking	1.3	2.5	7.1	1.5	0.2	0.9	0.4	1.9	1.8	-2.7
Alcohol usually taken with meals	2.3	3.7	6.6	-1.7	-2.6	-1.1	-0.7	-2.3	-2.1	2.1
Nervous feelings	2.8	5.2	7.5	1.9	2.7	1.7	2.7	2.1	2.2	-2.4
Frequency of tenseness / restlessness in last 2 weeks	2.2	3.4	6.9	1.7	1.3	1.9	2.6	1.3	1.7	-2.0
Hearing difficulty/problems with background noise	1.5	2.4	6.1	-1.4	-1.3	-2.5	-1.5	-1.8	-1.1	0.5
Hair/balding pattern: Pattern 2	0.3	0.3	1.2	-0.4	0.7	0.0	0.1	-0.4	-0.4	1.1
Had menopause	1.9	2.4	3.8	1.9	2.0	1.0	-0.9	1.7	1.7	-1.4
Had other major operations	0.3	0.4	1.0	0.9	0.6	0.4	-1.0	0.3	0.4	0.4
Forced vital capacity (FVC)	0.3	1.1	5.8	0.1	-0.9	-0.7	0.9	0.3	0.1	2.4
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.2	-0.4	0.4	0.3	0.4	-0.1	-0.3	-0.1
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.2	0.2	-0.2	1.0	1.0	-0.2	0.2	-1.1
Qualifications: None of the above	2.7	5.7	9.3	2.8	2.0	0.8	-1.7	2.5	3.1	-3.0
Financial difficulties in last 2 years	0.6	0.9	4.7	-0.5	0.2	0.5	2.2	-0.5	-0.6	0.2
Mouth/teeth dental problems	6.4	9.7	15.9	-3.0	-2.6	-2.5	-2.8	-3.4	-3.4	4.0
Heart attack	1.1	1.4	3.7	-1.1	0.3	-1.9	-1.5	-1.1	-1.0	0.6
Allergy	0.5	1.3	3.1	0.6	1.1	1.8	0.9	1.1	1.0	-1.1
Pain all over the body in last month	1.3	1.4	2.5	1.3	0.7	0.8	-1.6	1.1	1.2	-1.3
Diabetes (self-reported)	3.4	5.2	8.1	-1.9	-2.8	-2.7	-1.4	-2.4	-2.5	1.9
Hayfever/allergic rhinitis (self-reported)	4.7	6.3	11.6	-2.5	-3.4	-2.3	-1.9	-2.5	-2.6	1.9
Medication: Ramipril	0.9	1.1	3.3	1.3	1.8	0.3	-0.7	0.6	1.0	-0.8
Medication: Simvastatin	0.6	0.8	1.8	-0.6	-0.9	-0.8	-1.3	-0.9	-0.9	0.9
Fluid intelligence score	0.7	1.4	4.7	-0.7	-0.9	0.8	2.2	-0.9	-1.1	1.2
Illnesses of siblings	0.3	0.4	1.2	-0.6	-0.7	0.2	0.6	-0.1	-0.5	1.1
Neuroticism score	3.5	7.4	20.3	1.1	3.3	2.6	4.5	1.2	1.6	-2.8
Weight	0.1	0.5	1.2	1.0	-0.7	0.1	1.1	0.7	0.5	-0.5
Impedance of arm (right)	0.4	2.0	5.4	-1.9	-0.6	-0.5	-0.1	-1.6	-1.5	2.3
Arm fat percentage (right)	0.1	0.5	1.9	-0.4	-1.4	-0.6	-0.3	-0.5	-0.6	0.1
Trunk fat-free mass	0.0	0.3	0.6	0.3	-0.8	-0.7	0.7	-0.0	-0.0	0.4
Hip circumference	0.1	0.2	0.7	0.3	-0.9	-0.2	0.7	-0.1	-0.3	0.4
Time employed in main current job	3.6	4.2	7.3	2.0	2.7	1.8	0.9	2.2	2.1	-2.1
Alcohol intake versus 10 years previously	0.2	0.3	1.0	0.6	-0.1	0.3	-0.3	0.4	0.7	-1.0
Father’s age at death	0.1	0.1	0.5	-0.1	0.2	-0.3	-0.0	-0.2	-0.1	0.7
Worrier / anxious feelings	2.4	4.6	11.6	0.8	2.8	2.2	3.4	1.2	1.3	-1.9
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.6	-0.6	-0.4	0.2	1.2	-1.3	-0.9	0.2
Falls in the last year	0.2	0.3	0.9	-0.1	-0.1	-0.0	-0.9	-0.8	-0.5	0.1
Hair/balding pattern: Pattern 3	0.0	0.1	0.2	-0.3	-0.0	-0.4	-0.0	0.0	-0.2	-0.4
Number of live births	0.9	1.3	2.9	1.3	0.4	0.4	-1.7	1.0	1.0	-1.5
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	2.4	0.1	-0.3	-0.4	1.3	0.3	0.3	1.5
Pulse rate	0.1	0.1	0.4	0.2	0.0	0.2	0.3	0.3	0.6	0.5
Happiness	0.4	0.4	1.8	0.1	-0.8	0.5	1.3	0.0	0.2	-0.6
Noisy workplace	0.5	0.6	2.2	0.3	1.5	0.8	0.3	0.3	0.7	-0.9
Qualifications: A levels/AS levels or equivalent	0.6	1.3	3.6	-1.0	-1.2	0.3	1.9	-1.0	-1.0	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	1.3	0.4	0.7	0.6	1.2	0.2	0.2	0.0
Mouth/teeth dental problems: Dentures	7.1	12.0	20.5	3.6	3.3	2.2	1.1	4.1	4.1	-4.5
Asthma	0.1	0.3	0.9	0.4	-0.2	-0.9	-0.8	0.2	0.1	-0.4
Medication: Ibuprofen (e.g. Nurofen)	11.5	14.6	20.7	-4.5	-3.8	-3.8	-1.8	-4.5	-4.5	3.0
Medication: Cholesterol lowering	4.5	7.0	10.5	-2.6	-1.9	-2.9	-3.2	-2.7	-2.7	2.0
Depression (self-reported)	2.9	3.5	8.7	1.0	1.2	2.2	2.9	1.2	1.5	-2.2
Medication: Lansoprazole	1.2	1.4	2.0	1.4	1.2	1.0	-1.1	1.1	1.3	-0.8
Prospective memory result	2.0	2.4	5.2	-1.2	-1.8	-2.1	-2.3	-0.9	-1.0	0.7
Lung cancer (father)	2.7	3.1	4.9	2.2	1.6	1.9	0.8	1.9	1.9	-1.8
Illnesses of mother	1.5	1.8	4.2	1.3	0.5	0.8	1.7	2.0	1.6	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	3.6	-0.1	-0.5	-0.7	0.8	-0.2	-0.0	1.9
Pulse wave Arterial Stiffness index	0.7	0.8	2.7	-0.5	0.4	-1.6	-1.0	-0.6	-0.4	1.0
Impedance of arm (left)	0.2	1.1	3.1	-1.3	0.3	0.1	0.1	-1.1	-1.1	1.8
Arm fat mass (right)	0.1	0.2	1.3	0.4	-1.1	-0.3	0.1	0.2	0.0	-0.4
Trunk predicted mass	0.1	0.3	0.8	0.1	-0.9	-0.8	0.5	-0.1	-0.1	0.5
Standing height	0.1	1.1	4.9	0.7	0.3	-0.3	2.2	0.6	0.7	1.2
Length of working week for main job	1.2	1.3	3.3	-1.0	-1.8	-0.7	-0.2	-1.1	-1.1	1.3
Exposure to tobacco smoke at home	0.1	0.1	0.3	0.4	-0.4	0.3	0.1	0.5	0.1	0.2
Breastfed as a baby	0.2	0.3	0.9	-0.0	-0.5	1.0	0.6	-0.2	-0.2	0.4
Tense / ‘highly strung’	0.7	1.2	3.1	0.5	1.0	1.2	0.9	0.8	1.1	-1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.6	11.6	0.3	1.2	0.9	3.4	0.3	0.5	-2.0
Hair/balding pattern: Pattern 4	0.9	2.3	4.4	2.0	0.1	0.5	-0.3	1.9	2.1	-1.9
Birth weight of first child	0.7	1.3	6.5	-0.3	0.6	0.8	2.6	0.4	0.0	-1.1
Peak expiratory flow (PEF)	1.1	2.6	7.4	-1.2	-1.3	-2.0	0.6	-1.4	-1.1	2.7
Pulse wave reflection index	2.1	2.6	4.8	-1.7	-1.1	-2.2	-0.9	-1.8	-1.6	1.6
Ever highly irritable/argumentative for 2 days	0.3	0.3	1.3	-0.4	-0.8	-1.2	-0.3	-0.3	-0.3	0.1
Loud music exposure frequency	0.2	0.3	0.5	-0.6	-0.2	-0.4	0.5	-0.7	-0.5	-0.6
Qualifications: O levels/GCSEs or equivalent	3.9	6.2	12.1	-2.5	-2.9	-1.3	1.0	-2.7	-2.7	3.5
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.7	0.6	0.1	-0.1	0.8	0.3	0.4	0.3
Blood clot in the leg (DVT)	0.6	0.8	1.6	-0.4	-1.2	-1.2	-0.3	-0.5	-0.8	1.3
Medication: Paracetamol	0.3	0.5	1.6	-0.4	0.3	-0.5	1.0	-0.5	-0.5	-1.3
Headache pain in last month	1.5	2.6	5.3	-2.3	-1.1	-1.7	-0.3	-2.2	-1.9	0.3
Medication for cholesterol, blood pressure or diabetes	2.0	3.3	9.0	1.3	1.3	2.0	3.0	1.7	1.6	-1.0
Glaucoma (self-reported)	2.6	3.0	5.5	-2.0	-1.3	-2.3	-0.7	-1.8	-1.8	1.8
Gout (self-reported)	2.0	2.8	3.9	1.9	0.9	1.8	1.3	2.0	1.9	-1.6
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	2.2	1.4	1.5	0.1	-0.8	1.1	1.2	-1.3
Medication: Amlodipine	0.1	0.1	0.4	0.7	0.5	-0.2	-0.1	-0.2	-0.4	-0.3
Medication: Ventolin 100micrograms inhaler	0.8	1.0	1.7	0.9	1.3	1.2	0.6	1.0	0.7	-1.1
Birth weight	0.3	0.7	1.8	-1.2	-0.7	-0.2	1.4	-0.5	-0.7	0.6
Chronic bronchitis/emphysema (mother)	2.5	2.9	7.2	1.1	1.7	2.0	1.1	1.4	1.5	-2.7
High blood pressure (siblings)	0.1	0.1	0.4	0.2	0.6	-0.5	-0.1	-0.2	0.2	-0.1
Forced vital capacity (FVC), Best measure	0.3	1.2	6.7	-0.1	-0.9	-0.7	0.7	-0.3	-0.2	2.6
Body fat percentage	0.1	0.5	2.1	-0.2	-1.5	-0.7	0.1	-0.4	-0.6	0.2
Leg fat percentage (right)	0.8	3.0	6.8	-1.4	-2.6	-1.9	-1.1	-1.6	-1.7	1.5
Arm fat-free mass (right)	0.1	0.6	1.2	1.0	-0.6	-0.4	1.1	0.7	0.6	-0.6
Exposure to tobacco smoke outside home	3.3	4.5	8.0	1.6	2.8	2.7	2.0	1.5	1.4	-2.2
Comparative body size at age 10	0.2	0.5	1.4	-0.8	-0.7	-0.5	-1.2	-0.7	-0.6	-0.2
Number of full brothers	0.2	0.3	0.6	0.7	0.4	0.7	-0.3	0.4	0.5	-0.7
Worry too long after embarrassment	0.7	1.2	5.8	-0.4	0.5	1.2	2.4	-0.6	-0.4	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	3.5	-0.7	0.0	0.8	1.9	-0.6	-0.4	-1.2
Wheeze or whistling in the chest in last year	0.2	0.4	1.3	1.1	0.4	-0.2	-0.2	0.6	0.5	-0.9
Number of children fathered	0.7	0.8	2.6	-0.5	-0.0	-0.9	1.6	-0.4	-0.4	1.1
Reason for reducing amount of alcohol drunk: Health precaution	2.9	3.4	5.6	-1.8	-1.1	-1.7	-2.4	-1.8	-1.7	2.2
Age at first live birth	1.3	2.3	5.7	-1.7	-0.3	-2.4	0.4	-1.5	-1.8	1.4
Pulse wave peak to peak time	0.6	0.7	2.1	0.5	-0.5	1.5	1.2	0.6	0.3	-0.9
Health satisfaction	0.4	0.6	1.4	-0.5	-1.2	-1.0	0.2	-0.6	-0.7	0.5
Shortness of breath walking on level ground	0.2	0.2	0.5	0.6	0.2	-0.5	-0.0	0.7	0.6	-0.4
Qualifications: College or University degree	1.2	3.7	6.2	-2.2	-1.9	-0.9	0.0	-2.3	-2.5	2.1
Eye problems/disorders: None of the above	0.1	0.1	0.4	-0.1	-0.7	0.2	-0.3	-0.3	-0.3	0.0
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.3	0.7	0.4	1.1	0.8	0.7	0.7	-0.9
Emphysema/chronic bronchitis	1.3	1.5	3.2	1.8	1.2	0.2	0.7	1.6	1.5	-0.8
Medication for pain relief, constipation, heartburn	3.5	5.9	10.1	2.9	1.4	3.0	0.9	3.2	3.1	-1.2
Neck or shoulder pain in last month	6.0	8.5	11.7	-3.3	-3.1	-2.9	-0.6	-3.4	-3.2	2.8
Medication: Blood pressure	0.5	0.9	4.7	-0.1	0.3	-1.1	-2.2	-0.5	-0.6	0.1
Angina (self-reported)	2.5	3.3	4.8	-2.2	-0.9	-2.2	-1.2	-2.2	-1.9	1.7
Migraine (self-reported)	0.5	0.6	2.4	0.3	0.4	1.6	0.5	0.1	0.1	-1.1
Medication: Ibuprofen	13.1	15.6	21.8	-4.7	-4.0	-4.0	-1.4	-4.5	-4.6	3.5
Medication: Allopurinol	0.7	0.9	1.6	1.2	0.4	0.6	0.5	1.2	1.3	-0.8
Medication: Omeprazole	0.1	0.1	0.4	0.1	-0.3	-0.6	-0.4	-0.0	0.2	0.1
Medication: Seretide 50 evohaler	3.3	3.8	6.6	2.1	1.4	1.7	1.8	2.1	1.8	-2.6
Mean time to correctly identify matches	0.4	0.7	2.7	-0.5	1.2	-0.5	-0.3	0.2	-0.1	-1.6
Heart disease (mother)	3.6	4.4	9.4	-1.5	-2.0	-2.2	-3.1	-2.3	-1.7	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.8	0.3	-0.9	0.4	0.8	0.0	0.1	0.2
Whole body fat mass	0.1	0.4	1.8	0.2	-1.3	-0.7	0.4	-0.0	-0.1	-0.1
Leg fat mass (right)	0.3	1.3	4.6	-0.6	-2.1	-1.5	-0.3	-0.8	-0.9	0.7
Arm predicted mass (right)	0.1	0.5	1.0	1.0	-0.4	-0.1	1.0	0.6	0.6	-0.7
Pulse rate, automated reading	0.1	0.2	0.5	0.3	-0.7	0.7	-0.5	0.3	0.4	-0.2
Alcohol intake frequency.	8.9	20.6	28.4	4.7	3.6	4.3	2.8	5.2	5.2	-5.3
Comparative height size at age 10	0.3	1.6	2.2	1.4	1.3	-1.4	-1.1	1.3	1.5	-0.7
Number of full sisters	0.1	0.2	0.5	-0.2	-0.3	-0.2	-0.7	-0.6	-0.5	0.1
Suffer from ‘nerves’	1.6	2.4	5.8	0.6	2.4	1.2	2.1	1.0	1.2	-1.6
Overall health rating	0.4	0.9	3.8	1.0	-0.6	-0.7	-0.3	0.6	0.7	-2.0
Chest pain or discomfort	1.3	1.9	4.7	-1.5	-1.5	-0.5	0.7	-2.2	-1.8	0.8
Had major operations	0.6	0.7	1.6	-1.3	-0.5	-0.8	-1.0	-0.7	-0.7	0.4
Age at last live birth	0.4	0.5	2.5	-0.3	0.9	-1.6	-0.1	-0.3	-0.5	-0.1
Family relationship satisfaction	0.9	1.2	2.1	-1.3	-1.5	-0.9	0.7	-0.9	-1.0	1.0
Leg pain on walking	0.6	0.7	1.3	-1.0	-0.7	-0.6	-0.7	-1.1	-1.1	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	1.0	0.2	-1.0	0.0	-0.3	0.3	0.4	-0.2
Commuting to job workplace: Car/motor vehicle	1.4	1.6	4.2	-1.0	-0.9	-2.1	-0.6	-1.0	-1.1	1.6
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.8	-0.8	-0.6	-1.0	-1.7	-0.4	-0.4	0.2
Medication: Aspirin	3.7	4.9	11.8	-1.9	-0.8	-3.4	-1.9	-2.3	-2.4	1.9
Supplements: Vitamin C	3.1	3.7	6.7	-2.4	-1.3	-1.8	-0.7	-2.4	-2.6	1.4
Knee pain experienced in last month	0.6	1.0	2.0	-0.9	-1.4	0.0	1.0	-1.4	-1.1	0.0
Hypertension (Self-reported)	0.2	0.4	1.5	0.7	0.4	0.2	-1.2	-0.1	0.1	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.5	3.0	5.6	-1.6	-0.8	-2.4	-2.2	-1.6	-1.7	1.4
Illnesses of father: Heart disease	2.2	3.1	6.5	-1.3	-1.7	-1.7	-2.5	-1.9	-1.4	1.5
Illnesses of siblings: Diabetes	0.6	0.8	1.7	0.8	1.3	0.3	-0.0	0.7	0.9	-1.3
Smoking status: Previous	0.5	0.8	2.6	-0.6	0.8	-0.6	-0.7	-0.7	-0.7	1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	3.2	0.9	-1.8	-0.3	0.8	0.7	0.7	0.9
Whole body fat-free mass	0.1	0.5	1.3	1.0	-0.4	-0.1	1.1	0.8	0.7	-0.5
Leg fat-free mass (right)	0.5	2.9	5.0	2.2	0.4	1.0	1.9	2.0	1.9	-1.7
Arm fat percentage (left)	0.1	0.2	1.1	-0.1	-1.0	-0.3	-0.2	-0.2	-0.4	-0.3
Average weekly red wine intake	5.3	7.8	10.8	-2.9	-3.0	-2.9	-2.0	-3.2	-3.3	2.0
Handedness (chirality/laterality): Left-handed	1.8	2.2	5.0	1.5	1.5	2.2	-0.2	1.6	1.4	-0.9
Mood swings	2.7	4.9	13.0	1.2	2.7	2.2	3.6	1.0	1.2	-2.2
Loneliness, isolation	0.8	1.1	2.5	-1.6	-0.3	-0.7	0.9	-1.4	-1.2	-0.2
Long-standing illness, disability or infirmity	2.6	4.0	10.0	2.3	1.2	1.3	0.2	2.0	2.4	-3.2
Ever had bowel cancer screening	2.2	2.6	6.1	1.4	2.1	0.8	0.0	1.6	1.6	-2.5
Diabetes diagnosed by doctor	3.4	5.5	11.9	-1.6	-3.5	-2.8	-1.8	-2.0	-2.1	2.2
Ever had stillbirth, spontaneous miscarriage or termination	2.6	2.8	4.2	-1.9	-1.3	-1.3	0.4	-2.0	-2.0	2.1
Friendships satisfaction	2.7	3.3	8.9	-2.3	-3.0	-1.4	-1.0	-1.8	-1.6	0.8
Qualifications: nursing, teaching	1.0	1.6	2.6	-1.3	-0.2	-0.4	1.6	-1.4	-1.5	1.6
Commuting to job workplace: Walk	0.5	0.5	1.7	-0.2	-0.2	0.8	-1.3	-0.9	-0.3	-0.5
Eye problems/disorders: Cataract	1.0	1.1	2.0	1.0	0.8	0.8	1.3	1.4	1.2	-0.5
Mouth/teeth dental problems: Mouth ulcers	2.6	4.1	8.4	1.0	1.3	2.7	2.9	1.5	1.4	-2.5
Medication for cholesterol	1.6	2.5	4.8	-2.2	-1.4	-0.1	0.3	-1.7	-1.9	2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	4.5	1.1	2.1	-0.7	-0.3	1.0	1.1	-0.6
Back pain experienced in last month	0.7	1.0	4.9	-0.3	-1.1	-2.2	-0.5	-0.4	-0.2	-0.1
Mineral and other dietary supplements	0.8	1.1	2.0	1.4	1.1	0.6	-0.8	1.3	1.3	-0.7
Breast cancer (self-reported)	0.2	0.2	0.9	-0.3	-0.1	-0.3	-0.3	-0.5	-0.4	1.0
Asthma (self-reported)	0.1	0.2	0.7	0.4	-0.1	-0.9	-0.7	0.1	-0.0	-0.3
Osteoporosis (self-reported)	1.6	1.9	6.4	0.6	1.4	1.3	2.5	0.8	0.8	-1.4
Osteoarthritis (self-reported)	0.1	0.2	0.5	-0.5	-0.2	-0.5	0.1	-0.5	-0.3	-0.7
Medication: Aspirin	4.2	5.5	13.7	-1.9	-1.2	-3.7	-2.0	-2.3	-2.4	2.2
Medication: Gliclazide	2.3	2.6	4.4	-1.4	-0.8	-1.8	-1.5	-2.1	-1.9	1.5
Illnesses of father: None of the above (group 1)	3.8	4.6	6.3	2.2	2.2	2.1	2.0	2.5	2.3	-1.8
Smoking status: Current	0.4	0.7	2.7	-0.7	-0.6	0.5	1.6	-0.7	-0.7	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.5	-0.6	-1.1	-0.4	-0.9	-0.6	-0.4	1.2
Whole body water mass	0.1	0.5	1.1	1.0	-0.5	-0.2	1.0	0.7	0.7	-0.5
Leg predicted mass (right)	0.6	3.2	5.3	2.3	0.5	1.1	2.0	2.1	2.0	-1.8
Arm fat mass (left)	0.1	0.2	0.9	0.4	-1.0	-0.3	0.0	0.2	0.1	-0.6
Number of self-reported non-cancer illnesses	0.8	1.4	3.2	-0.7	-0.8	-1.5	-1.8	-1.3	-1.1	-0.6
Average weekly champagne plus white wine intake	2.3	3.2	8.9	-1.3	-1.7	-1.3	0.2	-2.0	-1.6	3.0
Miserableness	1.6	2.8	6.4	0.5	2.1	1.6	2.5	-0.1	0.7	-2.4
Guilty feelings	0.9	1.4	6.7	-0.3	1.3	1.1	2.6	-0.2	-0.2	0.2
Wears glasses or contact lenses	1.3	1.5	3.0	-1.5	-0.7	-0.9	-0.3	-1.7	-1.5	1.2
Ever taken oral contraceptive pill	2.4	2.7	4.9	-1.3	-2.2	-1.0	-1.3	-1.6	-1.7	2.0
Hearing aid user	0.8	0.9	4.1	0.3	-0.9	-0.9	-2.0	0.3	0.4	-0.5
Mother’s age at death	1.7	2.2	3.9	-1.5	0.7	-1.0	-1.1	-1.9	-1.7	2.0
Financial situation satisfaction	2.4	2.9	5.1	-2.2	-2.1	-0.9	-0.5	-1.9	-1.9	1.7
Tinnitus: Yes, now most or all of the time	1.7	2.0	2.9	-1.5	-1.2	-1.6	-0.6	-1.6	-1.7	1.4
Commuting to job workplace: Public transport	2.0	2.3	6.9	1.2	1.5	2.6	0.7	0.8	1.0	-1.9
Eye problems/disorders: Glaucoma	4.4	5.2	8.6	-2.5	-2.0	-2.9	-1.6	-2.1	-2.2	2.4
Medication: Blood pressure	1.5	2.8	6.1	2.1	1.9	0.9	0.3	1.4	1.6	-2.5
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.1	-1.2	-0.8	-0.6	0.2	-1.4	-1.2	0.4
Supplements: Fish oil (including cod liver oil)	0.9	1.2	2.4	-1.6	-1.3	-0.7	-0.6	-1.4	-1.3	0.1
High cholesterol (Self-reported)	0.9	1.5	4.3	-0.8	-1.1	-0.3	-2.1	-1.4	-1.2	1.0
Medication: Bendroflumethiazide	1.2	1.8	3.5	1.9	0.9	1.2	0.9	1.4	1.7	-0.9
Medication: Paracetamol	0.5	0.7	2.7	-0.5	-0.2	-0.3	1.7	-0.6	-0.6	-1.2
Medication: Lisinopril	2.6	3.4	5.3	-2.1	-1.2	-2.1	-1.7	-2.3	-2.2	0.4
Medication: Atorvastatin	1.8	2.2	9.7	0.1	-1.0	-1.8	-3.1	-0.4	-0.3	1.1
Illnesses of father: High blood pressure	0.1	0.1	0.3	-0.3	-0.1	-0.5	-0.3	-0.5	-0.2	0.4
Alcohol drinker status: Never	4.4	5.2	8.1	2.1	2.1	2.6	1.8	2.1	2.3	-2.8
Ever smoked	2.3	4.0	7.5	-2.2	-0.8	-0.8	-0.2	-2.6	-2.6	2.7
Basal metabolic rate	0.1	0.6	1.5	1.0	-0.6	-0.1	1.2	0.7	0.6	-0.4
Leg fat percentage (left)	0.4	1.4	4.2	-0.7	-2.0	-1.5	-0.6	-0.9	-1.0	0.9
Arm fat-free mass (left)	0.1	0.4	1.3	0.6	-1.2	-0.7	0.6	0.3	0.3	-0.1
Number of operations (self-reported)	1.0	1.5	1.9	-1.4	-1.1	-1.3	-1.3	-1.2	-1.3	0.9
Average weekly beer plus cider intake	1.4	2.1	4.2	2.0	0.7	0.5	-1.7	1.8	1.7	-0.9
Irritability	1.1	1.8	4.6	0.6	1.8	1.2	2.1	0.4	0.7	-1.5
Risk taking	0.2	0.3	0.5	0.4	-0.3	-0.3	0.7	0.7	0.5	-0.4
Ever had prostate specific antigen (PSA) test	1.1	1.2	2.6	-1.5	-0.3	-0.7	-1.6	-1.2	-1.0	0.6
Fractured/broken bones in last 5 years	0.2	0.3	1.1	0.4	-0.2	0.2	1.0	0.3	0.3	0.7
Age started oral contraceptive pill	0.8	1.0	2.0	0.9	1.4	-0.7	-1.2	0.7	1.0	-1.0
Diastolic blood pressure, automated reading	0.4	1.3	3.0	1.3	-1.0	0.6	-1.3	0.8	0.5	-1.7
Ever depressed for a whole week	3.5	4.3	8.4	2.0	0.9	2.9	2.2	1.6	1.9	-2.4
Unable to work because of sickness or disability	4.0	5.2	8.6	2.6	1.9	2.2	1.1	2.3	2.6	-2.9
Commuting to job workplace: Cycle	0.4	0.5	1.3	-0.6	0.9	0.5	1.1	-0.3	-0.5	-0.5
Myopia	0.3	0.4	1.1	0.9	0.4	1.1	0.6	-0.1	0.1	0.5
Vascular/heart problems diagnosed by doctor	0.2	0.6	2.7	-0.5	-0.1	-0.0	1.6	0.3	0.0	0.9
Cholesterol lowering medication	0.4	0.7	1.9	1.4	0.1	-0.3	-0.8	0.9	1.1	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.4	-0.3	-0.6	-0.6	-0.0	-0.4	-0.2	0.4
Pain experienced in last month	1.6	2.6	5.2	1.9	1.9	1.6	-0.1	2.3	1.9	-0.1
Supplements: Calcium	0.7	0.8	3.1	-0.4	1.3	-0.3	1.8	-0.5	-0.3	0.2
Basal cell carcinoma (self-reported)	0.4	0.5	1.4	-0.3	1.0	-0.5	-0.7	-0.3	-0.4	1.2
Heart attack/myocardial infarction (self-reported)	1.1	1.4	3.8	-1.2	0.4	-2.0	-1.3	-1.1	-1.1	0.5
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.4	-0.3	-1.0	-1.1	-0.3	-0.3	-0.6	1.2
Heart disease (siblings)	0.6	0.8	2.7	-0.5	-0.3	-1.1	-1.6	-0.7	-0.4	-0.7
Alcohol drinker status: Previous	0.3	0.3	0.7	0.1	0.8	0.5	0.1	0.4	0.4	-0.8
Pack years of smoking	5.8	8.6	11.1	3.2	2.9	2.4	2.8	3.3	3.3	-2.5
Impedance of whole body	0.5	2.4	6.6	-1.9	-0.7	-0.7	-0.2	-1.7	-1.6	2.6
Leg fat mass (left)	0.2	0.7	3.1	-0.2	-1.8	-1.1	-0.0	-0.4	-0.5	0.4
Arm predicted mass (left)	0.1	0.5	1.4	0.8	-1.2	-0.6	0.9	0.5	0.4	-0.2