Best TWAS P=4.33e-16 · Best GWAS P=1.06e-27 conditioned to 8.59e-10
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Cerebellar Hemisphere | CDR2L | 0.31 | 0.00 | enet | 14 | 0.03 | 5.3e-02 | 0.072 | 6.6 | 4.0e-11 | -0.51 | 0.04 | 0.14 | FALSE |
2 | GTEx | Testis | RAB37 | 0.27 | 0.20 | lasso | 4 | 0.16 | 9.5e-08 | 7.715 | -7.4 | 1.7e-13 | 0.06 | 0.97 | 0.00 | FALSE |
3 | METSIM | Adipose | FBF1 | 0.20 | 0.09 | enet | 41 | 0.12 | 2.5e-17 | -3.594 | -6.1 | 9.3e-10 | -0.02 | 0.99 | 0.01 | TRUE |
4 | NTR | Blood | CD300LF | 0.03 | 0.02 | enet | 21 | 0.02 | 2.9e-07 | -5.784 | 6.4 | 1.9e-10 | -0.40 | 0.92 | 0.06 | FALSE |
5 | NTR | Blood | SLC9A3R1 | 0.02 | 0.02 | lasso | 2 | 0.01 | 1.2e-05 | 7.765 | -7.8 | 8.2e-15 | 0.07 | 0.70 | 0.02 | TRUE |
6 | YFS | Blood | CD300LF | 0.15 | 0.09 | bslmm | 440 | 0.12 | 2.3e-38 | -5.784 | 8.1 | 4.3e-16 | -0.67 | 1.00 | 0.00 | TRUE |
7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | JMJD6 | 0.08 | 0.09 | blup | 37 | 0.09 | 1.5e-10 | -5.600 | 5.6 | 2.7e-08 | -0.04 | 0.00 | 1.00 | TRUE |
8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MXRA7 | 0.45 | 0.51 | lasso | 5 | 0.54 | 3.5e-71 | -5.109 | 5.2 | 2.0e-07 | -0.04 | 0.05 | 0.95 | FALSE |
9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CD300LF | 0.05 | 0.02 | blup | 49 | 0.03 | 4.2e-04 | -6.820 | 5.7 | 1.1e-08 | -0.56 | 0.35 | 0.29 | FALSE |
10 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CD300LF | 0.20 | 0.01 | blup | 47 | 0.04 | 1.4e-02 | -2.030 | 5.2 | 2.6e-07 | -0.47 | 0.01 | 0.07 | FALSE |
11 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | SLC9A3R1 | 0.17 | 0.05 | lasso | 4 | 0.04 | 1.1e-02 | -5.496 | 5.5 | 2.9e-08 | -0.02 | 0.08 | 0.04 | FALSE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | FAM100B | 0.25 | 0.11 | enet | 21 | 0.17 | 5.1e-16 | 3.918 | -5.1 | 2.9e-07 | 0.07 | 0.03 | 0.74 | TRUE |