TWAS hub - CD300LF

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0326	0.0130	0.00130	0.016	0.012	0.020	0.016	0.019	5.1e-06	8.1e-05	2.8e-07	4.4e-06	5.1e-07
2	YFS	Blood	0.1528	0.0238	0.00000	0.085	0.110	0.114	0.124	0.120	2.0e-26	4.2e-34	4.0e-35	2.3e-38	4.1e-37
3	TCGA	Breast Invasive Carcinoma	0.0295	0.0149	0.00150	0.005	0.010	0.003	NA	0.004	3.0e-02	2.8e-03	5.7e-02	NA	4.4e-02
4	TCGA	Brain Lower Grade Glioma	0.0546	0.0254	0.00021	0.023	0.027	0.025	NA	0.024	1.0e-03	4.2e-04	7.5e-04	NA	7.9e-04
5	TCGA	Pheochromocytoma and Paraganglioma	0.2020	0.0860	0.00360	0.012	0.036	0.003	NA	0.036	1.0e-01	1.4e-02	2.4e-01	NA	1.5e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Hayfever, allergic rhinitis or eczema	5.0	10.8	18.5	-3.5	-4.3	-2.3	-3.7	-2.1
Blood White Count	4.6	34.1	66.1	6.4	8.1	2.1	5.7	5.2
Allergy or Eczema	3.9	10.3	20.8	-3.9	-4.6	-1.6	-3.2	-1.5
Illnesses of siblings: Diabetes	3.8	4.6	7.9	0.3	2.0	2.6	2.8	2.1
Triglycerides	3.7	6.0	7.5	-2.5	-2.7	-2.1	-2.6	-2.2
Pulse rate	3.3	5.6	10.1	3.0	3.2	1.6	2.5	0.3
Hearing aid user	3.2	3.6	6.3	-1.3	-2.5	-1.6	-2.0	-1.9
Age when periods started (menarche)	3.1	7.4	13.4	0.0	2.7	3.7	2.9	2.8
Major Depression (MDD)	2.8	3.3	5.5	-0.7	-2.3	-1.6	-1.9	-2.1
Reason for reducing amount of alcohol drunk: Health precaution	2.5	2.9	5.0	-1.5	-2.2	-1.4	-2.0	-1.2
LDL Cholesterol	2.4	3.8	5.4	-2.3	-2.3	-1.6	-1.9	-1.4
Chronic bronchitis/emphysema (father)	2.4	2.8	4.6	-1.4	-2.1	-0.9	-2.0	-1.6
Allergy	2.4	5.5	9.1	2.6	3.0	1.4	2.7	1.4
Mother’s age at death	2.4	3.0	4.1	2.0	1.9	1.2	1.8	1.6
Medication: Aspirin	2.2	2.8	5.9	-0.1	-2.4	-1.9	-2.2	-0.4
Prostate Cancer	2.1	2.9	5.6	1.5	2.3	0.8	2.4	1.0
Diverticular disease/diverticulitis (self-reported)	2.0	2.4	4.5	-2.1	-1.9	-0.6	-1.4	-1.2
Medication: Seretide 50 evohaler	2.0	2.3	3.3	-0.4	-1.8	-1.7	-1.5	-1.7
Ever had bowel cancer screening	2.0	2.3	3.8	-2.0	-1.8	-0.4	-0.9	-1.8
Average weekly beer plus cider intake	2.0	2.9	6.4	-2.0	-2.5	-0.4	-1.0	-1.7
Mean Putamen Volume	1.9	2.1	4.1	2.0	1.4	1.2	1.2	1.4
Blood Platelet Count	1.9	21.8	44.2	3.0	6.7	3.7	5.1	4.0
Stomach or abdominal pain in last month	1.9	2.3	6.2	-1.0	-1.5	-1.4	-2.5	-0.3
Hayfever/allergic rhinitis (self-reported)	1.9	2.5	4.9	-2.2	-2.2	-0.3	-1.7	-0.0
Heart disease (mother)	1.9	2.3	5.1	0.7	-1.2	-2.3	-1.9	-0.7
Financial situation satisfaction	1.8	2.2	4.5	1.6	1.7	0.5	1.1	2.1
Ulcerative Colitis	1.6	2.3	7.2	2.7	0.4	-1.7	-0.4	-1.1
Pain all over the body in last month	1.6	1.7	3.6	1.6	1.3	0.7	1.9	0.6
Ever taken oral contraceptive pill	1.6	1.8	4.0	-1.2	-1.4	-0.6	-1.0	-2.0
Fractured/broken bones in last 5 years	1.6	2.1	5.0	0.1	-1.6	-1.1	-1.3	-2.2
Heart attack	1.5	2.0	3.1	-0.7	-1.8	-1.8	-1.4	-1.0
Ever highly irritable/argumentative for 2 days	1.5	1.8	5.9	2.4	0.9	-1.4	-0.2	-0.4
Medication: Ventolin 100micrograms inhaler	1.5	1.9	5.3	0.2	1.1	2.3	1.4	1.0
Medication: Aspirin	1.5	2.0	4.7	-0.7	-2.2	-1.4	-1.7	-0.0
Deep venous thrombosis (DVT) (self-reported)	1.5	1.9	3.4	1.1	0.6	1.8	1.8	1.1
Neuroticism (2016)	1.4	2.0	3.2	1.2	1.5	1.0	1.4	1.8
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	5.2	2.3	0.5	0.3	0.9	1.1
Basal cell carcinoma (self-reported)	1.4	1.7	4.6	2.1	1.8	0.2	0.6	-0.4
Rheumatoid Arthritis	1.3	1.8	3.6	0.6	1.7	1.4	1.9	0.5
Cardiovascular Disease	1.3	4.4	7.3	0.4	-2.2	-2.7	-2.5	-1.9
High blood pressure (mother)	1.3	1.8	2.5	0.4	-1.6	-1.4	-1.4	-1.5
Blood clot in the leg (DVT)	1.3	1.7	3.3	0.9	0.6	1.8	1.7	1.1
Pulse rate, automated reading	1.3	4.3	7.6	1.9	2.8	1.1	2.7	1.3
Commuting to job workplace: Walk	1.3	1.4	2.3	-0.3	1.0	1.4	1.5	1.4
Heart attack/myocardial infarction (self-reported)	1.3	1.7	2.9	-0.6	-1.7	-1.7	-1.3	-1.0
Fed-up feelings	1.2	2.2	4.1	0.2	2.0	1.2	1.8	1.5
Number of incorrect matches in round	1.2	2.0	2.7	-1.5	-1.6	-0.7	-1.4	-1.6
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	3.6	1.4	-0.9	-1.9	-1.2	-0.5
Ever depressed for a whole week	1.2	1.5	4.2	0.7	-0.1	-1.4	-0.9	-2.0
Hearing difficulty/problems: Yes	1.1	1.7	5.6	-1.6	-0.3	-0.0	0.2	-2.4
Taking other prescription medications	1.1	1.8	3.5	-1.6	-1.9	-0.0	-1.1	-1.2
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.8	2.3	1.4	1.5	1.4	1.5	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	3.0	0.2	-1.4	-1.1	-1.7	-1.4
Wheeze or whistling in the chest in last year	1.1	1.9	4.0	-1.0	-1.5	-1.3	-2.0	-0.9
Medication: Bendroflumethiazide	1.1	1.7	5.0	-0.0	0.6	1.4	1.1	2.2
Intelligence (Savage-Jansen 2018)	1.0	3.0	5.7	0.7	1.5	2.1	2.4	1.4
Crohns Disease (2012)	1.0	1.6	4.2	-0.9	-2.0	-1.3	-1.0	-0.4
Severe depression (siblings)	1.0	1.1	2.9	1.1	1.7	0.8	0.6	0.4
Loud music exposure frequency	1.0	1.1	3.5	0.7	0.1	1.0	0.7	1.9
High blood pressure (siblings)	1.0	1.4	1.8	0.6	-1.3	-1.4	-1.2	-1.3
Health satisfaction	1.0	1.3	2.0	0.9	1.4	1.1	1.4	0.7
Number of full sisters	1.0	1.2	1.9	1.0	0.1	-1.3	-1.4	-1.1
Chest pain or discomfort	1.0	1.4	4.8	-0.1	-1.0	-1.1	-2.2	-0.2
Handedness (chirality/laterality): Left-handed	1.0	1.2	2.4	-1.2	0.2	1.2	0.7	1.5
Loneliness, isolation	1.0	1.3	2.9	-1.2	-0.6	-1.1	-0.8	-1.7
Ever had prostate specific antigen (PSA) test	1.0	1.2	3.7	-1.9	-0.6	0.1	-0.2	-1.4
Cholesterol lowering medication	1.0	1.4	2.8	0.5	-0.8	-1.3	-1.7	-1.3
Nervous feelings	0.9	1.6	4.6	-0.7	0.1	2.2	1.0	1.3
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	2.3	1.5	1.2	0.1	0.6	-1.1
Lung cancer (father)	0.9	1.1	4.0	2.0	1.1	-0.1	0.4	0.0
Headache pain in last month	0.9	1.6	2.3	-1.0	-1.3	-1.1	-1.5	-1.3
Number of children fathered	0.9	1.0	3.5	-0.0	-0.9	-1.9	-0.1	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	2.3	1.5	0.4	-1.0	0.0	-1.4
Smoking status: Current	0.9	1.5	2.8	-0.1	-1.1	-1.7	-1.6	-0.9
Guilty feelings	0.9	1.4	4.3	2.1	0.4	-1.3	-0.3	-0.9
Wears glasses or contact lenses	0.9	1.0	2.5	-0.5	-0.5	0.9	1.1	-1.6
High cholesterol (Self-reported)	0.9	1.5	3.3	0.5	-0.5	-1.7	-1.8	-0.9
Heart disease (siblings)	0.9	1.1	2.0	0.2	1.2	0.5	1.4	1.4
Schizophrenia (2014)	0.8	1.8	2.2	1.2	1.5	1.3	1.5	1.1
Lung FEV1/FVC ratio	0.8	4.0	9.4	1.2	3.1	1.1	2.5	1.3
Medication: Atenolol	0.8	0.9	2.2	1.2	-0.5	-1.5	-0.9	-0.4
Number of live births	0.8	1.2	2.2	-0.8	-1.0	-0.1	-1.5	-1.4
Length of working week for main job	0.8	0.9	1.8	-0.4	-0.4	-0.9	-1.3	-1.3
Overall health rating	0.8	1.8	3.1	1.8	0.9	0.8	1.4	1.6
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.8	0.0	-0.7	-0.7	-0.8	-1.7
Qualifications: nursing, teaching	0.8	1.2	2.5	-1.6	-1.2	-0.8	-0.4	-1.1
Illnesses of father: None of the above (group 1)	0.8	1.0	2.6	0.5	1.6	0.6	0.8	1.1
Risk taking	0.8	1.2	2.0	-1.2	-1.2	-0.7	-0.9	-1.4
Worry (Nagel 2018)	0.7	1.4	4.0	0.0	0.5	2.0	1.5	0.7
Alzheimer’s Disease (in father)	0.7	0.8	2.1	0.6	-0.7	-1.0	-1.4	-0.2
Crohns Disease (2017)	0.7	1.4	3.2	-1.8	-1.7	0.4	-0.6	0.8
Lupus	0.7	1.1	2.0	1.4	1.2	0.1	0.7	1.3
Smoking Status	0.7	1.7	2.7	-0.2	-1.5	-1.3	-1.6	-1.3
Hypothyroidism (self reported)	0.7	1.6	2.8	1.7	-0.4	-1.6	-1.4	-0.7
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.9	0.5	-0.9	-0.8	-1.4	-0.9
Serious illness, injury or assault to yourself	0.7	0.8	1.5	-1.2	-1.2	0.3	-0.6	-0.6
Alcohol usually taken with meals	0.7	1.2	3.4	0.0	0.2	-1.5	-0.6	-1.9
Noisy workplace	0.7	0.9	1.7	-0.4	0.8	1.1	1.3	0.7
Pulse wave reflection index	0.7	0.9	1.7	-0.9	-1.2	-0.5	-1.3	-0.5
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.1	-0.7	1.2	1.4	1.1	0.8
Pulse wave peak to peak time	0.7	0.8	1.6	-0.8	-1.3	-0.9	-0.9	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.8	1.3	1.0	0.3	1.0	-0.3
Friendships satisfaction	0.7	0.9	1.6	0.4	0.8	0.9	1.0	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	3.0	0.9	1.3	1.7	1.4	0.2
Schizophrenia (2018)	0.6	1.3	2.0	0.6	1.0	1.4	1.2	1.2
Coronary Artery Disease (CAD)	0.6	0.7	3.2	1.8	0.5	0.0	0.0	0.0
HDL Cholesterol	0.6	1.0	2.6	0.4	0.4	1.3	0.6	1.6
BMI	0.6	3.8	8.0	0.1	-1.2	-2.6	-1.6	-2.8
Type 2 Diabetes (T2D) (2018)	0.6	1.2	1.7	1.1	1.3	0.9	1.2	1.0
Lung FVC	0.6	3.0	5.2	1.9	1.6	1.5	2.3	1.0
Hearing difficulty/problems with background noise	0.6	0.9	3.0	-1.3	-0.3	0.1	-0.2	-1.7
Had menopause	0.6	0.7	1.4	0.5	0.4	1.2	1.1	0.7
Time employed in main current job	0.6	0.7	2.4	1.6	0.2	-0.7	-0.5	0.2
Worrier / anxious feelings	0.6	1.1	2.5	1.6	1.0	0.4	1.1	0.9
Prospective memory result	0.6	0.8	2.5	-1.6	-0.6	0.1	-0.5	0.8
Pulse wave Arterial Stiffness index	0.6	0.7	1.2	1.0	1.1	0.8	0.8	0.2
Exposure to tobacco smoke at home	0.6	0.6	1.7	0.5	0.3	1.3	0.9	0.5
Breastfed as a baby	0.6	0.7	2.1	-0.0	-1.1	-0.0	-0.3	1.5
Suffer from ‘nerves’	0.6	1.0	1.8	-1.3	-1.0	0.8	-0.1	-1.1
Average weekly red wine intake	0.6	0.9	1.5	-0.9	-0.9	-1.2	-1.0	-0.5
Long-standing illness, disability or infirmity	0.6	0.9	2.7	-0.2	-1.6	-0.3	-0.6	-1.1
Breast cancer (self-reported)	0.6	0.7	1.5	-1.1	-1.2	0.0	-0.8	-0.0
Arm fat-free mass (left)	0.6	2.8	10.2	0.5	-0.8	-1.3	-1.2	-3.2
Pain experienced in last month	0.6	0.9	1.3	0.8	0.9	0.8	1.1	1.2
Schizophrenia vs Biploar Disorder	0.5	0.6	1.5	0.4	0.8	0.8	1.2	0.5
Alzheimer’s Disease (in mother)	0.5	0.6	1.2	0.7	1.0	-1.1	-0.1	-0.5
Alzheimer’s Disease (including proxy)	0.5	0.7	1.5	1.2	0.7	-1.1	-0.6	0.2
Respiratory disease	0.5	1.0	2.6	-1.4	-1.6	-0.2	-0.8	-0.2
Neuroticism	0.5	1.1	1.7	0.7	1.0	1.2	1.3	0.9
Pack years adult smoking proportion	0.5	0.7	1.6	0.8	-0.8	-1.3	-0.5	-0.7
Current tobacco smoking	0.5	0.9	1.9	0.1	-0.7	-1.4	-1.1	-0.8
Supplements: Glucosamine	0.5	0.6	0.9	-0.7	-0.8	-0.9	-0.6	-0.9
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.4	1.2	0.5	-1.1	-0.0	-0.4
Qualifications: None of the above	0.5	1.1	3.8	0.8	1.9	0.4	0.9	0.4
Impedance of arm (right)	0.5	2.3	6.6	-1.8	-0.4	1.2	0.3	2.6
Trunk fat-free mass	0.5	3.0	10.4	0.1	-1.2	-1.2	-1.3	-3.2
Medication: Cholesterol lowering	0.5	0.9	2.1	-0.5	-1.5	-0.7	-1.1	-0.3
Depression (self-reported)	0.5	0.6	1.6	0.5	-0.1	-1.1	-0.1	-1.3
Trunk predicted mass	0.5	2.9	10.1	0.2	-1.2	-1.1	-1.3	-3.2
Hair/balding pattern: Pattern 4	0.5	1.3	4.0	2.0	1.0	-0.6	0.7	0.8
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	3.2	1.8	-0.1	-0.6	-0.8	0.4
Arm fat-free mass (right)	0.5	2.6	8.9	1.0	-0.4	-1.4	-1.0	-3.0
Comparative body size at age 10	0.5	1.4	3.6	-0.2	0.8	1.5	1.9	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	2.6	1.6	0.7	-0.3	0.2	0.0
Mouth/teeth dental problems: Loose teeth	0.5	0.7	1.1	-0.1	-1.0	-1.0	-1.0	-0.5
Medication: Omeprazole	0.5	0.5	2.3	0.2	-0.6	-0.3	-0.1	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.5	0.9	-0.9	-0.8	-0.5	-1.0	-0.3
Arm predicted mass (right)	0.5	2.5	8.6	1.1	-0.3	-1.3	-0.9	-2.9
Leg pain on walking	0.5	0.7	1.8	-0.3	0.1	1.2	0.2	1.4
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.7	-1.3	-1.1	-0.0	-0.4	-0.2
Knee pain experienced in last month	0.5	0.8	1.6	-0.1	-0.7	-1.1	-1.0	-1.3
Whole body fat-free mass	0.5	2.9	10.2	0.1	-0.9	-1.3	-1.3	-3.2
Eye problems/disorders: Cataract	0.5	0.5	1.6	-1.3	-0.9	-0.4	-0.4	-0.1
Medication for cholesterol	0.5	0.7	1.3	-0.9	0.5	1.1	1.0	0.3
Whole body water mass	0.5	2.6	9.2	0.1	-0.9	-1.3	-1.2	-3.0
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.1	-0.7	0.0	0.8	0.8	1.0
Medication: Lisinopril	0.5	0.6	2.4	1.5	0.4	-0.5	-0.2	-0.3
Basal metabolic rate	0.5	2.6	9.2	-0.1	-0.9	-1.3	-1.2	-3.0
Age started oral contraceptive pill	0.5	0.6	1.4	-0.3	-1.0	-0.3	-0.8	-1.2
Unable to work because of sickness or disability	0.5	0.6	1.6	1.3	0.3	0.5	0.9	0.5
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	2.4	0.3	-0.5	-0.4	-0.1	-1.6
Pack years of smoking	0.5	0.8	1.4	0.5	-1.2	-1.2	-0.6	-0.7
Arm predicted mass (left)	0.5	2.5	8.6	0.4	-0.8	-1.3	-1.2	-2.9
Ulcerative Colitis (UC)	0.4	0.7	1.8	1.3	0.9	0.2	0.3	0.9
Primary Biliary Cirrhosis	0.4	0.5	1.1	-0.5	0.7	0.7	0.3	1.1
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.9	-0.6	0.1	0.0	0.0	1.4
Blood Red Count	0.4	3.9	8.0	0.6	-1.9	-2.5	-2.8	-1.2
Chronotype (morning person)	0.4	1.0	4.2	2.0	0.8	-0.1	0.2	-0.3
Medication for hormone replacement therapy	0.4	0.4	0.7	0.8	-0.2	0.3	-0.8	0.8
Diabetes (father)	0.4	0.5	1.0	-1.0	-0.4	0.6	0.5	0.8
Relative age voice broke	0.4	0.6	1.0	-0.8	-0.6	0.8	0.2	1.0
Body mass index (BMI)	0.4	1.5	5.8	-0.4	-0.3	-1.2	-0.4	-2.4
Impedance of leg (left)	0.4	1.8	6.8	1.0	0.3	0.8	0.7	2.6
Leg predicted mass (left)	0.4	2.0	6.8	-0.5	-0.7	-1.2	-1.0	-2.6
Medication: Ramipril	0.4	0.6	1.3	-0.3	-1.1	-0.8	-0.7	-0.6
Medication: Simvastatin	0.4	0.6	1.6	0.3	-0.7	-0.8	-1.3	-0.0
Illnesses of siblings	0.4	0.6	1.9	-1.4	-0.5	0.5	-0.8	-0.1
Hip circumference	0.4	1.8	3.9	-1.2	-1.3	-0.9	-1.2	-2.0
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	3.0	1.7	1.0	0.9	1.4	-0.2
Mouth/teeth dental problems: Dentures	0.4	0.7	1.3	0.7	0.4	0.9	0.8	1.1
Impedance of arm (left)	0.4	2.1	7.4	-1.3	-0.0	1.0	0.4	2.7
Tense / ‘highly strung’	0.4	0.6	2.1	-1.4	-0.9	0.5	-0.2	-0.1
Medication: Amlodipine	0.4	0.6	1.3	1.1	0.8	-0.1	0.0	1.0
Eye problems/disorders: None of the above	0.4	0.5	1.4	0.5	0.3	0.7	0.4	-1.2
Emphysema/chronic bronchitis	0.4	0.4	1.0	-0.7	-1.0	-0.4	-0.6	0.0
Neck or shoulder pain in last month	0.4	0.6	1.1	-0.3	-0.4	-0.7	-1.0	-1.0
Medication: Ibuprofen	0.4	0.5	0.8	-0.7	0.8	0.9	0.4	0.5
Alcohol intake frequency.	0.4	0.9	3.4	1.8	1.0	-0.1	0.5	-0.3
Leg fat-free mass (right)	0.4	2.0	6.8	-0.6	-0.6	-1.1	-1.0	-2.6
Eye problems/disorders: Glaucoma	0.4	0.5	1.6	-1.3	-0.3	-0.3	-0.3	0.6
Supplements: Fish oil (including cod liver oil)	0.4	0.6	2.1	1.5	0.7	-0.1	0.2	-0.4
Medication: Paracetamol	0.4	0.6	1.6	0.1	1.3	0.9	0.9	-0.1
Medication: Atorvastatin	0.4	0.5	0.8	0.1	-0.9	-0.8	-0.8	-0.4
Alcohol drinker status: Never	0.4	0.5	1.0	-0.5	-1.0	-0.3	-0.7	-0.7
Supplements: Calcium	0.4	0.4	1.5	0.3	-0.5	0.5	-0.0	1.2
Impedance of whole body	0.4	2.0	8.3	-0.3	0.3	1.0	0.6	2.9
Reaction Time	0.3	0.7	1.3	0.2	-0.7	-0.8	-1.1	-0.9
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.2	0.7	0.6	1.1	0.9	0.7
Breast Cancer	0.3	0.7	2.6	1.6	0.4	-0.1	0.2	-0.9
Ovarian Cancer	0.3	0.4	0.8	-0.2	0.9	0.9	-0.3	0.6
Number of treatments/medications taken	0.3	0.6	1.5	-0.5	-1.2	0.3	-0.9	-0.3
Sensitivity / hurt feelings	0.3	0.5	1.2	1.1	0.9	-0.0	0.1	0.4
Ever had hysterectomy (womb removed)	0.3	0.3	0.8	0.3	0.6	0.3	0.4	0.9
Medication: Co-codamol	0.3	0.3	0.7	0.7	0.2	-0.6	0.0	0.8
Diabetes (mother)	0.3	0.3	0.7	0.2	0.9	0.3	0.8	-0.6
Impedance of leg (right)	0.3	1.6	6.0	1.1	0.1	0.8	0.6	2.4
Leg fat-free mass (left)	0.3	1.8	6.5	-0.4	-0.6	-1.1	-0.9	-2.5
Townsend deprivation index at recruitment	0.3	0.4	1.1	-0.4	-0.1	1.0	-0.2	0.7
Average weekly fortified wine intake	0.3	0.4	0.8	-0.2	0.7	0.8	0.9	0.2
Qualifications: CSEs or equivalent	0.3	0.4	1.3	-0.2	0.4	-1.1	-0.5	-0.5
High blood pressure	0.3	0.8	3.1	1.8	0.5	-0.0	0.3	0.7
Medication: Levothyroxine sodium	0.3	0.5	1.1	1.0	-0.5	-0.2	-0.7	0.6
Waist circumference	0.3	0.9	3.4	-0.2	-0.4	-0.8	-0.6	-1.8
Forced vital capacity (FVC)	0.3	1.0	2.8	1.7	0.5	0.8	1.1	-0.3
Fluid intelligence score	0.3	0.7	1.2	0.7	0.6	1.0	1.1	0.7
Weight	0.3	1.7	6.5	-0.5	-0.6	-1.0	-0.6	-2.5
Arm fat percentage (right)	0.3	1.2	2.9	-1.2	-0.6	-1.0	-0.5	-1.7
Father’s age at death	0.3	0.3	0.9	0.2	0.2	1.0	0.7	0.5
Hair/balding pattern: Pattern 3	0.3	0.5	0.9	0.2	0.7	0.9	0.9	-0.2
Arm fat mass (right)	0.3	1.4	4.5	-0.8	-0.5	-1.1	-0.6	-2.1
Birth weight of first child	0.3	0.5	1.2	-1.1	-0.8	0.0	-0.3	-0.8
Birth weight	0.3	0.6	2.6	0.4	-0.2	-0.4	-0.3	-1.6
Exposure to tobacco smoke outside home	0.3	0.4	1.1	1.0	0.9	-0.1	-0.4	0.1
Number of full brothers	0.3	0.4	1.1	0.0	-0.1	0.2	-0.9	1.0
Shortness of breath walking on level ground	0.3	0.4	1.5	1.2	0.3	-0.1	-0.4	-0.3
Medication: Blood pressure	0.3	0.5	2.1	1.4	-0.0	-0.6	-0.1	0.3
Supplements: Vitamin C	0.3	0.3	1.1	0.1	0.2	0.4	0.5	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.7	-0.6	-0.0	0.8	-0.3	0.6
Asthma (self-reported)	0.3	0.6	1.1	-0.5	-0.9	-0.7	-1.0	-0.4
Medication: Gliclazide	0.3	0.4	0.9	-0.0	-0.2	0.4	1.0	-0.8
Leg predicted mass (right)	0.3	1.8	6.6	-0.5	-0.5	-1.1	-1.0	-2.6
Arm fat mass (left)	0.3	1.2	4.2	-0.6	-0.3	-1.1	-0.5	-2.0
Medication: Blood pressure	0.3	0.6	1.7	1.3	0.6	-0.8	-0.1	0.3
Number of operations (self-reported)	0.3	0.4	1.0	1.0	0.8	0.4	0.5	-0.3
Diastolic blood pressure, automated reading	0.3	0.9	1.9	0.8	1.0	-0.6	0.6	-1.4
Commuting to job workplace: Cycle	0.3	0.4	0.8	0.6	0.8	0.9	0.5	0.3
Vascular/heart problems diagnosed by doctor	0.3	0.7	2.6	-1.6	0.2	0.7	0.5	-0.3
Alcohol drinker status: Previous	0.3	0.4	1.8	1.3	0.1	-0.0	-0.1	0.2
Bipolar Disorder (2018)	0.2	0.4	0.9	-0.1	-0.5	-1.0	-0.8	0.0
Depression (Nagel 2018)	0.2	0.3	0.8	-0.6	-0.4	0.9	0.5	0.3
Neuroticism (Nagel 2018)	0.2	0.4	0.9	0.1	0.3	1.0	0.9	0.5
Fasting Glucose	0.2	0.2	0.5	-0.5	-0.7	-0.4	-0.0	-0.3
Heel T-Score	0.2	1.6	3.5	1.9	1.3	-0.2	0.9	1.4
Average weekly spirits intake	0.2	0.3	0.8	-0.3	0.3	0.6	0.1	-0.9
Systolic blood pressure, automated reading	0.2	0.5	1.3	-0.8	-0.4	-0.7	-0.4	-1.2
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.4	0.4	-0.4	0.6	0.4	0.7
Angina	0.2	0.2	0.6	-0.0	-0.8	-0.0	-0.0	0.7
Medication: Metformin	0.2	0.3	0.7	0.4	0.7	0.4	0.8	-0.1
Multivitamins +/- minerals	0.2	0.3	0.8	0.3	-0.9	-0.5	-0.2	-0.3
Trunk fat mass	0.2	0.8	2.1	-0.6	-0.3	-1.1	-0.4	-1.5
Had other major operations	0.2	0.3	1.0	1.0	0.3	-0.3	-0.5	-0.4
Mouth/teeth dental problems	0.2	0.3	1.1	0.1	1.0	0.4	0.7	0.0
Diabetes (self-reported)	0.2	0.3	1.1	-0.3	-0.2	1.1	0.1	0.6
Neuroticism score	0.2	0.4	0.7	0.7	0.6	0.7	0.8	0.1
Falls in the last year	0.2	0.3	0.8	0.2	-0.6	-0.2	-0.4	-0.9
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.0	-0.5	-0.2	1.0	0.8	0.4
Medication: Lansoprazole	0.2	0.2	0.7	0.6	-0.1	-0.1	-0.0	-0.8
Glaucoma (self-reported)	0.2	0.2	0.4	-0.5	-0.2	-0.6	-0.2	-0.5
Gout (self-reported)	0.2	0.3	0.7	-0.3	0.0	-0.7	0.0	-0.9
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.9	0.9	-0.1	-0.2	-0.1	-0.3
Angina (self-reported)	0.2	0.2	0.8	-0.1	-0.9	-0.3	-0.2	0.3
Migraine (self-reported)	0.2	0.2	0.9	-0.3	0.2	0.3	0.2	0.9
Medication: Allopurinol	0.2	0.3	0.5	-0.6	0.5	0.7	0.7	0.2
Whole body fat mass	0.2	0.7	2.3	-0.3	-0.2	-1.0	-0.3	-1.5
Had major operations	0.2	0.2	0.5	-0.0	-0.2	0.7	0.7	-0.0
Age at last live birth	0.2	0.3	0.7	-0.4	-0.8	-0.3	-0.7	-0.3
Hypertension (Self-reported)	0.2	0.6	2.3	1.5	0.5	-0.1	0.3	0.3
Illnesses of father: Heart disease	0.2	0.2	0.9	-0.3	-1.0	-0.3	-0.3	-0.3
Smoking status: Previous	0.2	0.4	1.1	0.3	0.6	1.1	0.5	0.1
Arm fat percentage (left)	0.2	0.9	2.1	-1.1	-0.4	-1.0	-0.3	-1.4
Mood swings	0.2	0.4	1.1	0.7	-0.2	-1.0	-0.3	-0.7
Diabetes diagnosed by doctor	0.2	0.3	0.9	-0.5	-0.2	0.9	0.6	0.4
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.8	-0.9	-0.4	-0.4	-0.4	-0.0
Back pain experienced in last month	0.2	0.3	0.5	-0.7	-0.5	-0.2	-0.4	-0.7
Mineral and other dietary supplements	0.2	0.2	0.7	-0.8	-0.5	-0.0	-0.2	0.4
Osteoarthritis (self-reported)	0.2	0.2	0.4	0.3	0.4	0.5	0.5	-0.6
Miserableness	0.2	0.3	0.6	0.7	0.1	-0.8	-0.3	-0.6
Commuting to job workplace: Public transport	0.2	0.3	1.0	-0.5	-0.2	-1.0	0.0	0.3
Ever smoked	0.2	0.3	0.8	0.9	-0.2	-0.7	-0.2	0.3
Leg fat mass (left)	0.2	0.6	2.1	0.1	-0.2	-0.9	-0.2	-1.5
Bipolar Disorder or Schizophrenia	0.1	0.3	0.8	0.5	0.4	0.5	0.4	0.9
Depressed Affect (Nagel 2018)	0.1	0.2	0.7	-0.2	0.4	0.5	0.8	0.2
Irritable Bowel Disease (IBD)	0.1	0.2	0.5	-0.2	-0.5	0.2	-0.2	0.7
Body Mass Index (BMI) (2010)	0.1	0.2	0.4	-0.1	0.6	0.2	0.6	-0.1
HbA1C	0.1	0.1	0.2	-0.0	0.2	0.4	0.5	0.2
Blood Eosinophil Count	0.1	0.5	1.6	-1.3	-0.2	0.0	0.1	-0.9
Systolic Blood Pressure	0.1	0.4	0.9	0.3	-0.6	-0.9	-0.8	0.2
Tanning	0.1	1.4	3.7	-1.9	-1.5	0.3	-0.7	0.5
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.4	-0.5	-0.6	0.6	-0.2	-0.2
Vitamin and mineral supplements	0.1	0.1	0.6	0.0	0.8	-0.1	-0.1	-0.3
Supplements: Zinc	0.1	0.1	0.2	-0.1	-0.3	0.5	0.4	0.3
Trunk fat percentage	0.1	0.4	0.9	-0.6	-0.1	-1.0	-0.2	-0.8
Maternal smoking around birth	0.1	0.2	0.3	0.3	0.5	0.3	0.5	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.3	-0.2	-0.3	-0.3	-0.5	-0.1
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	0.5	0.3	0.0	0.2	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	1.2	1.1	0.2	-0.1	0.1	0.0
Past tobacco smoking	0.1	0.2	0.5	-0.7	-0.0	-0.4	0.1	-0.5
Hair/balding pattern: Pattern 2	0.1	0.2	0.4	-0.5	-0.6	-0.3	-0.4	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.9	0.9	-0.0	-0.2	-0.1	0.4
Financial difficulties in last 2 years	0.1	0.2	0.3	-0.4	0.4	-0.6	0.0	-0.4
Alcohol intake versus 10 years previously	0.1	0.2	0.5	0.1	0.4	-0.0	0.7	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.4	0.6	0.1	0.1	-0.1	0.4
Happiness	0.1	0.2	0.6	0.4	0.2	0.2	0.3	0.8
Asthma	0.1	0.2	0.4	-0.3	-0.5	-0.6	-0.7	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.7	-0.8	0.4	0.3	-0.1	-0.1
Illnesses of mother	0.1	0.2	0.3	-0.6	-0.1	0.4	-0.2	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.7	0.8	0.0	0.1	0.2	-0.7
Peak expiratory flow (PEF)	0.1	0.3	1.4	0.5	0.0	-0.2	0.1	-1.2
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.7	0.3	-0.8	0.5	-0.0	-0.1
Medication: Paracetamol	0.1	0.2	0.5	0.1	0.7	0.3	0.3	-0.7
Forced vital capacity (FVC), Best measure	0.1	0.3	0.9	1.0	-0.4	0.2	0.0	-0.6
Body fat percentage	0.1	0.3	0.8	-0.3	-0.1	-0.8	-0.0	-0.9
Worry too long after embarrassment	0.1	0.2	0.5	0.5	0.2	0.7	0.3	-0.1
Qualifications: College or University degree	0.1	0.3	0.6	0.8	-0.2	-0.7	0.1	0.3
Medication for pain relief, constipation, heartburn	0.1	0.2	0.2	-0.4	-0.5	-0.4	-0.3	0.5
Mean time to correctly identify matches	0.1	0.2	0.9	-0.1	-0.9	-0.1	-0.4	-0.5
Leg fat mass (right)	0.1	0.5	2.0	0.1	-0.2	-0.7	-0.0	-1.4
Comparative height size at age 10	0.1	0.3	1.3	0.1	-1.1	0.3	0.0	-0.1
Family relationship satisfaction	0.1	0.2	0.3	-0.2	0.4	0.5	0.4	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.5	0.7	-0.5	-0.6	-0.0	-0.2
Osteoporosis (self-reported)	0.1	0.1	0.2	0.4	-0.1	-0.2	-0.2	0.4
Number of self-reported non-cancer illnesses	0.1	0.2	0.5	0.2	-0.5	-0.2	-0.7	-0.1
Average weekly champagne plus white wine intake	0.1	0.2	0.6	-0.0	0.8	-0.2	-0.4	0.1
Illnesses of father: High blood pressure	0.1	0.1	0.2	-0.5	-0.4	-0.1	-0.0	0.0
Leg fat percentage (left)	0.1	0.2	0.3	0.5	0.3	-0.5	0.4	-0.6
Irritability	0.1	0.2	0.5	-0.7	-0.4	0.4	0.4	-0.1
Myopia	0.1	0.1	0.2	-0.4	0.5	-0.1	0.5	-0.2
Age at First Birth	0.0	0.0	0.1	-0.2	-0.1	0.1	-0.0	0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Height	0.0	0.4	0.8	0.9	0.8	-0.4	-0.1	-0.5
Waist Hip Ratio (WHR)	0.0	0.2	0.5	0.6	-0.0	-0.7	-0.4	-0.0
Hair Pigment	0.0	0.6	1.5	0.7	0.5	0.6	1.2	0.8
Hand grip strength (left)	0.0	0.0	0.1	0.2	0.1	-0.2	-0.1	0.2
Relative age of first facial hair	0.0	0.1	0.1	0.1	-0.0	-0.4	0.3	-0.2
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.1	0.1	-0.1	0.2	-0.0	0.0
Hand grip strength (right)	0.0	0.0	0.1	0.0	-0.2	-0.1	-0.3	0.0
Sitting height	0.0	0.2	0.3	-0.2	-0.6	-0.4	-0.4	-0.5
Standing height	0.0	0.3	0.7	0.0	-0.8	-0.1	-0.5	-0.8
Leg fat percentage (right)	0.0	0.2	0.5	0.4	0.1	-0.3	0.4	-0.7
Age at first live birth	0.0	0.1	0.1	-0.2	-0.3	-0.3	-0.2	0.2
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.1	0.1	0.1	0.1	0.1	0.3
Pain type(s) experienced in last month: Hip pain	0.0	0.1	0.1	-0.1	0.3	-0.3	0.3	-0.0

Hub : Genes

CD300LF

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Trait associations