Hub : Genes

RAB37

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.212	0.044	1.1e-08	0.213	0.118	0.214	0.215	0.218	2.0e-25	3.5e-14	1.3e-25	9.6e-26	4.2e-26
2	GTEx	Brain Cerebellar Hemisphere	0.364	0.111	1.4e-03	0.170	NA	0.028	NA	0.126	4.0e-05	NA	6.3e-02	NA	4.0e-04
3	GTEx	Brain Cerebellum	0.319	0.104	2.2e-03	0.357	NA	0.318	NA	0.366	2.1e-11	NA	4.0e-10	NA	9.6e-12
4	GTEx	Testis	0.266	0.085	1.0e-03	0.199	NA	0.152	NA	0.164	3.2e-09	NA	2.9e-07	NA	9.5e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.2	0.3	0.9	-0.2	-0.3	-1.0	0.0
Bipolar Disorder or Schizophrenia	0.0	0.1	0.2	-0.4	0.4	-0.1	-0.1
Depressed Affect (Nagel 2018)	0.7	1.5	2.9	-1.2	1.1	0.7	-1.7
Depression (Nagel 2018)	0.4	0.6	1.1	1.0	1.0	0.5	-0.4
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.8	1.3	-0.7	-0.4	0.7
Neuroticism (Nagel 2018)	0.3	0.8	1.4	-0.4	1.1	0.7	-1.2
Schizophrenia (2018)	0.1	0.3	0.6	-0.3	0.8	0.7	-0.2
Schizophrenia vs Biploar Disorder	0.9	1.2	3.4	0.3	-0.5	-1.0	-1.9
Worry (Nagel 2018)	0.1	0.2	0.4	0.6	-0.2	-0.4	-0.2
Alzheimer’s Disease (in mother)	0.5	0.6	1.3	-0.6	0.6	0.7	-1.1
Alzheimer’s Disease (in father)	0.9	1.0	2.6	1.6	-0.8	-0.6	0.3
Alzheimer’s Disease (including proxy)	0.8	1.2	3.3	1.0	-0.7	-0.3	-1.8
Crohns Disease (2017)	0.1	0.2	0.6	0.8	-0.2	0.1	0.1
Irritable Bowel Disease (IBD)	0.1	0.3	0.7	0.6	-0.2	-0.0	0.8
Ulcerative Colitis (UC)	0.4	0.7	2.2	0.7	-0.2	-0.1	1.5
Major Depression (MDD)	0.7	0.8	2.3	-0.2	1.0	1.5	0.0
Reaction Time	0.2	0.3	0.7	0.4	-0.6	-0.3	-0.8
Verbal and Numeric Reasoning (VNR)	0.5	1.3	3.1	0.8	-0.9	-0.8	1.8
Breast Cancer	1.3	3.1	10.4	0.9	-0.9	-0.7	-3.2
Ovarian Cancer	1.7	2.3	8.4	2.9	-0.6	-0.5	-0.4
Prostate Cancer	1.4	1.9	3.5	-0.4	-1.4	-1.9	-1.4
Age at First Birth	0.6	0.9	1.5	-0.5	1.2	1.1	0.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.1	-0.1	0.0	-0.4	0.1
Coronary Artery Disease (CAD)	0.6	0.7	1.5	-0.3	-0.5	-0.9	-1.2
Crohns Disease (2012)	0.0	0.0	0.1	-0.3	0.3	0.0	0.0
Mean Putamen Volume	1.3	1.5	3.0	1.7	0.3	0.8	-1.4
Fasting Glucose	0.5	0.5	1.1	-0.1	-1.1	-0.5	0.9
HbA1C	0.6	0.7	1.3	-0.1	0.5	1.1	1.2
HDL Cholesterol	0.4	0.7	2.2	1.5	-0.5	-0.1	-0.6
LDL Cholesterol	1.0	1.6	3.2	-0.0	-1.8	-1.6	0.8
Lupus	0.2	0.3	0.6	0.2	0.8	0.7	0.5
Neuroticism (2016)	0.7	1.1	1.9	-1.4	0.9	1.2	0.4
Primary Biliary Cirrhosis	0.7	1.0	2.8	0.7	0.0	0.8	1.7
Rheumatoid Arthritis	0.8	1.1	2.1	-1.5	-1.2	-0.9	-0.3
Schizophrenia (2014)	0.1	0.2	0.6	-0.4	-0.1	-0.2	-0.8
Triglycerides	0.6	1.0	2.1	-0.5	-1.3	-1.4	0.4
Type 2 Diabetes (T2D) (2012)	1.2	1.4	4.7	-0.5	-0.5	-0.6	-2.2
Ulcerative Colitis	0.2	0.4	1.0	0.0	-0.6	-1.0	-0.3
Blood Eosinophil Count	0.4	2.7	3.6	-1.9	-1.6	-1.6	1.5
Blood Platelet Count	0.5	5.6	16.2	1.9	1.0	1.1	4.0
Blood Red Count	0.1	1.3	5.1	0.3	-0.1	-0.2	2.3
Blood White Count	1.9	13.9	54.3	1.0	-0.0	0.6	-7.4
Heel T-Score	0.4	3.2	12.4	-0.4	-0.2	-0.3	-3.5
BMI	0.5	2.9	6.8	-2.6	-1.7	-1.4	0.1
Height	0.1	2.4	5.3	-2.3	0.7	0.5	1.8
Waist Hip Ratio (WHR)	0.1	0.3	0.9	0.9	0.3	-0.1	0.2
Systolic Blood Pressure	0.2	0.8	2.7	1.6	0.4	0.1	-0.7
Smoking Status	0.7	1.8	2.6	-1.1	1.4	1.1	-1.6
Allergy or Eczema	1.3	3.5	11.6	-1.5	-0.1	0.3	3.4
Cardiovascular Disease	0.2	0.7	1.4	1.1	0.4	0.4	-1.2
Hypothyroidism (self reported)	0.4	1.0	2.2	0.1	0.8	1.0	-1.5
Respiratory disease	0.8	1.7	4.9	-0.8	-0.8	-0.9	2.2
Type 2 Diabetes (T2D) (2018)	0.3	0.6	2.2	0.1	-0.5	-0.1	-1.5
Lung FEV1/FVC ratio	0.5	2.3	4.0	0.2	1.2	2.0	-2.0
Lung FVC	0.1	0.3	0.5	0.7	-0.4	-0.6	-0.1
Neuroticism	0.4	1.0	1.2	-1.0	1.1	0.7	-1.1
Chronotype (morning person)	0.4	0.8	1.9	1.4	0.5	0.9	0.5
Hair Pigment	0.0	1.0	1.8	-0.5	1.1	1.3	0.9
Tanning	0.0	0.2	0.3	-0.4	-0.2	0.3	0.5
Hand grip strength (left)	1.0	2.6	6.0	-1.5	1.3	0.7	2.4
Number of treatments/medications taken	1.4	2.6	8.5	2.9	0.0	-0.2	-1.4
Average weekly spirits intake	0.6	0.7	1.4	0.6	-1.2	-1.1	-0.2
Sensitivity / hurt feelings	0.9	1.5	2.5	-0.6	1.6	1.5	-1.0
Frequency of depressed mood in last 2 weeks	1.6	2.2	3.3	1.8	1.8	1.6	0.0
Hearing difficulty/problems: Yes	0.6	1.0	1.6	-1.1	-1.2	-1.1	0.0
Relative age of first facial hair	0.1	0.3	0.9	-1.0	0.1	0.3	-0.1
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.1	0.2	0.2	0.2	0.0
Ever used hormone-replacement therapy (HRT)	0.4	0.6	1.1	1.0	0.8	0.6	-0.4
Ever had hysterectomy (womb removed)	0.0	0.0	0.1	-0.2	-0.2	0.1	0.2
Systolic blood pressure, automated reading	0.7	2.2	4.5	-0.8	-1.9	-2.1	-0.4
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	-0.5	-0.2	-0.2	-0.0
Angina	1.0	1.3	1.9	-0.7	1.4	1.1	1.2
Medication for hormone replacement therapy	1.8	2.0	6.0	2.5	-0.4	0.2	1.4
Vitamin and mineral supplements	0.5	0.7	1.7	-1.3	-0.5	-0.4	-0.9
Supplements: Zinc	0.4	0.4	0.9	0.4	0.5	0.5	0.9
Medication: Co-codamol	0.1	0.1	0.3	-0.4	-0.6	-0.2	-0.2
Medication: Metformin	0.0	0.0	0.1	-0.2	0.0	0.0	0.2
Diabetes (father)	0.0	0.1	0.1	0.1	0.2	0.3	-0.3
Diabetes (mother)	0.7	1.0	1.6	-0.3	-0.9	-1.1	-1.2
Severe depression (siblings)	1.5	1.7	6.0	0.2	0.7	0.5	2.5
Pack years adult smoking proportion	0.3	0.4	0.8	-0.9	0.0	-0.4	0.9
Impedance of leg (right)	0.8	4.1	8.4	2.9	1.3	1.1	2.3
Leg fat-free mass (left)	0.3	1.7	5.3	-2.3	-0.6	-1.1	0.1
Trunk fat percentage	0.4	1.7	3.1	-1.8	-1.5	-1.3	-0.1
Hand grip strength (right)	0.5	1.3	3.3	-0.6	1.2	0.4	1.8
Townsend deprivation index at recruitment	1.1	1.6	4.2	2.0	-0.4	0.2	-1.4
Current tobacco smoking	0.8	1.2	4.4	-0.3	0.6	0.3	-2.1
Average weekly fortified wine intake	0.7	0.8	1.5	-0.5	1.0	1.2	0.7
Maternal smoking around birth	0.3	0.4	0.9	-1.0	0.2	0.5	0.8
Fed-up feelings	0.9	1.5	2.1	0.8	1.4	1.3	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	3.0	1.7	1.1	1.1	-0.5
Relative age voice broke	0.3	0.5	1.6	1.3	0.1	0.4	0.3
Taking other prescription medications	0.3	0.5	1.0	0.2	-1.0	-0.7	-0.7
Age when periods started (menarche)	0.7	1.6	6.2	2.5	-0.2	0.1	-0.5
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	-0.3	-0.4	-0.6	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	1.5	-0.2	-1.2	-1.0	-1.1
Tinnitus: Yes, but not now, but have in the past	2.0	2.1	6.2	-0.0	0.6	1.4	2.5
Qualifications: CSEs or equivalent	0.3	0.4	1.4	0.2	0.3	0.5	-1.2
Serious illness, injury or assault to yourself	0.5	0.6	1.7	-0.0	1.3	1.0	0.1
High blood pressure	0.3	0.8	1.4	1.2	-0.4	-0.5	-1.2
Hayfever, allergic rhinitis or eczema	2.1	4.5	14.1	-1.9	0.0	0.4	3.8
Multivitamins +/- minerals	0.2	0.3	0.7	0.7	0.1	0.1	0.8
Stomach or abdominal pain in last month	1.2	1.5	2.6	0.9	1.6	1.3	1.0
Supplements: Glucosamine	0.4	0.5	1.2	-0.7	-0.6	-0.2	1.1
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.7	0.6	-0.5	-0.8	-0.1
Medication: Atenolol	0.7	0.9	1.7	-1.3	-0.4	-0.8	1.0
Medication: Levothyroxine sodium	1.5	2.5	7.3	2.7	0.5	0.9	-1.3
Sitting height	0.1	0.5	1.5	-0.5	-0.1	-0.5	1.2
Chronic bronchitis/emphysema (father)	1.1	1.3	2.5	-0.0	1.0	1.3	1.6
High blood pressure (mother)	1.2	1.7	3.8	1.0	-1.4	-1.9	-0.1
Body mass index (BMI)	0.4	1.8	5.7	-2.4	-0.8	-0.7	-0.5
Impedance of leg (left)	0.9	4.3	9.7	3.1	1.2	1.1	2.2
Leg predicted mass (left)	0.3	1.7	5.4	-2.3	-0.6	-1.1	0.1
Trunk fat mass	0.5	2.0	5.0	-2.2	-1.2	-1.2	0.2
Waist circumference	0.3	1.0	2.4	-1.5	-0.8	-1.0	0.1
Number of incorrect matches in round	0.3	0.5	1.2	-0.5	-0.8	-1.1	0.3
Past tobacco smoking	0.7	1.3	2.5	-0.5	-1.6	-1.6	-0.2
Alcohol usually taken with meals	0.4	0.6	1.5	-0.1	-1.2	-1.0	-0.4
Nervous feelings	1.1	2.1	3.9	2.0	1.5	1.5	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	2.4	-0.3	1.3	1.5	0.9
Hearing difficulty/problems with background noise	0.6	0.9	3.5	-1.9	0.2	-0.1	-0.2
Hair/balding pattern: Pattern 2	1.0	1.2	3.0	-0.2	1.7	1.2	0.7
Had menopause	0.2	0.3	0.7	-0.4	0.3	0.8	-0.6
Had other major operations	0.1	0.1	0.3	-0.1	0.6	0.3	0.3
Forced vital capacity (FVC)	0.2	0.6	1.4	0.7	1.2	0.6	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.0	-0.7	-0.9	-0.7	-1.4
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.6	0.4	-0.8	-0.7	0.2
Qualifications: None of the above	0.6	1.3	3.8	-0.4	0.6	0.9	-1.9
Financial difficulties in last 2 years	0.9	1.2	2.5	1.6	1.1	0.6	-0.8
Mouth/teeth dental problems	0.5	0.7	2.7	0.2	-0.2	-0.2	1.6
Heart attack	0.8	1.0	2.0	-1.4	0.8	0.9	0.8
Allergy	1.4	3.1	10.2	1.4	-0.0	-0.4	-3.2
Pain all over the body in last month	1.9	2.0	2.9	0.3	1.4	1.7	-1.7
Diabetes (self-reported)	0.1	0.2	0.3	-0.1	-0.5	-0.5	-0.4
Hayfever/allergic rhinitis (self-reported)	1.2	1.5	2.5	0.4	1.3	1.6	1.4
Medication: Ramipril	0.4	0.5	0.8	0.8	-0.6	-0.9	-0.5
Medication: Simvastatin	0.3	0.5	1.1	1.1	0.6	0.4	-0.5
Fluid intelligence score	0.2	0.4	0.5	0.7	-0.7	-0.5	0.6
Illnesses of siblings	1.3	1.9	5.6	2.4	-0.2	-0.5	1.3
Neuroticism score	0.5	1.0	2.2	-0.2	1.5	1.3	-0.3
Weight	0.3	1.6	5.7	-2.4	-0.3	-0.6	0.6
Impedance of arm (right)	0.2	1.0	2.6	1.6	0.8	0.9	0.3
Arm fat percentage (right)	0.4	1.6	5.8	-2.4	-0.7	-0.4	-0.3
Trunk fat-free mass	0.2	1.3	3.3	-1.8	0.6	0.2	1.2
Hip circumference	0.3	1.2	3.0	-1.7	-0.9	-0.9	0.4
Time employed in main current job	0.4	0.4	0.6	0.8	-0.8	-0.6	-0.1
Alcohol intake versus 10 years previously	0.5	0.7	1.2	-0.3	-1.1	-1.1	0.6
Father’s age at death	1.0	1.4	1.8	1.2	-1.1	-1.3	1.0
Worrier / anxious feelings	0.2	0.4	0.8	-0.9	0.3	0.4	-0.9
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	2.7	1.6	1.4	1.6	0.0
Falls in the last year	1.1	1.5	2.5	1.6	1.0	1.5	0.3
Hair/balding pattern: Pattern 3	0.8	1.1	2.1	0.1	-1.4	-1.0	-1.2
Number of live births	0.2	0.2	0.9	-0.1	-0.0	0.1	-1.0
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.5	0.3	0.7	0.3	0.1
Pulse rate	1.1	1.9	3.6	0.3	-1.9	-1.2	-1.5
Happiness	0.2	0.3	0.8	0.1	-0.3	-0.4	0.9
Noisy workplace	2.6	3.3	7.4	-0.1	2.2	2.7	-0.9
Qualifications: A levels/AS levels or equivalent	0.7	1.5	4.7	1.0	0.6	-0.3	2.2
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.1	0.5	-0.5	-1.1	0.9
Mouth/teeth dental problems: Dentures	0.7	1.1	3.9	0.5	0.2	0.6	-2.0
Asthma	0.4	0.7	2.3	-0.8	-0.1	0.0	1.5
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.8	1.4	0.5	0.1	0.0
Medication: Cholesterol lowering	0.1	0.1	0.3	0.6	-0.2	-0.1	0.1
Depression (self-reported)	0.1	0.1	0.4	-0.0	0.7	0.1	0.2
Medication: Lansoprazole	0.3	0.3	0.6	0.1	0.6	0.8	-0.5
Prospective memory result	0.6	0.8	2.1	1.0	0.2	-0.1	-1.4
Lung cancer (father)	2.4	2.8	6.3	0.1	-1.6	-1.5	-2.5
Illnesses of mother	1.0	1.2	2.6	-0.8	1.6	1.3	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.2	0.4	0.5	0.1	0.5
Pulse wave Arterial Stiffness index	1.3	1.5	4.1	1.1	-0.6	-0.6	-2.0
Impedance of arm (left)	0.2	0.7	2.0	1.4	0.5	0.7	0.4
Arm fat mass (right)	0.4	1.5	4.8	-2.2	-0.7	-0.7	-0.3
Trunk predicted mass	0.2	1.2	3.1	-1.8	0.7	0.3	1.1
Standing height	0.2	2.1	6.3	-0.5	1.2	0.4	2.5
Length of working week for main job	1.1	1.2	2.9	-0.6	1.1	1.7	0.4
Exposure to tobacco smoke at home	0.2	0.2	0.6	-0.8	-0.4	-0.2	0.2
Breastfed as a baby	0.6	0.7	1.5	1.2	-0.0	-0.0	1.2
Tense / ‘highly strung’	0.6	1.0	2.1	1.2	-0.6	-0.6	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.7	1.3	0.7	0.7	0.2
Hair/balding pattern: Pattern 4	0.2	0.5	0.7	-0.8	-0.9	-0.4	-0.6
Birth weight of first child	1.3	2.4	7.1	-2.7	-0.7	-1.2	-0.9
Peak expiratory flow (PEF)	0.2	0.4	0.8	-0.8	0.2	-0.1	0.9
Pulse wave reflection index	1.1	1.4	4.8	0.3	-0.6	-0.7	-2.2
Ever highly irritable/argumentative for 2 days	1.6	1.9	2.7	-1.0	-1.6	-1.3	-1.6
Loud music exposure frequency	0.4	0.4	0.7	0.4	-0.8	-0.5	-0.8
Qualifications: O levels/GCSEs or equivalent	0.3	0.6	1.1	1.1	-0.3	-0.6	0.7
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	0.8	-0.9	-0.0	-0.5	-0.5
Blood clot in the leg (DVT)	0.7	0.9	2.4	0.6	0.6	1.5	-0.8
Medication: Paracetamol	1.0	1.6	3.7	1.9	1.1	0.5	-1.1
Headache pain in last month	0.2	0.4	1.3	-1.2	0.1	-0.2	-0.5
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	0.7	0.2	0.8	0.8	0.7
Glaucoma (self-reported)	0.8	1.0	2.3	-0.4	-0.9	-0.7	1.5
Gout (self-reported)	1.2	1.7	3.6	-1.3	-0.8	-0.9	-1.9
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	3.2	1.8	1.1	1.5	-1.5
Medication: Amlodipine	0.4	0.6	1.4	0.5	0.5	0.6	-1.2
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.9	-0.0	-0.9	-0.5	0.3
Birth weight	0.4	0.8	2.0	-0.6	-0.6	-1.4	0.8
Chronic bronchitis/emphysema (mother)	1.4	1.6	4.3	-2.1	0.7	1.2	0.7
High blood pressure (siblings)	0.6	0.9	2.4	-1.6	0.3	0.5	0.8
Forced vital capacity (FVC), Best measure	0.2	0.7	1.1	0.6	1.1	0.6	0.9
Body fat percentage	0.4	1.5	3.8	-2.0	-1.1	-0.9	0.1
Leg fat percentage (right)	0.1	0.4	1.1	-1.0	-0.1	0.0	0.8
Arm fat-free mass (right)	0.2	1.1	3.2	-1.8	-0.3	-0.9	0.6
Exposure to tobacco smoke outside home	1.1	1.4	5.0	2.2	0.3	0.6	-0.5
Comparative body size at age 10	0.5	1.4	2.1	-1.5	1.1	1.4	-0.4
Number of full brothers	0.5	0.6	1.4	0.5	-0.9	-0.5	1.2
Worry too long after embarrassment	0.6	1.1	2.9	0.1	1.7	1.1	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.9	3.5	-1.1	1.5	1.9	-0.7
Wheeze or whistling in the chest in last year	0.6	1.0	3.0	-1.7	-0.4	-0.4	-0.9
Number of children fathered	1.4	1.6	3.9	-2.0	1.1	0.8	0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	4.1	-1.9	0.0	-0.4	2.0
Age at first live birth	0.6	1.1	3.4	1.8	-0.5	-0.8	0.4
Pulse wave peak to peak time	2.1	2.5	6.5	-1.3	0.9	0.8	2.5
Health satisfaction	0.5	0.6	1.6	0.4	0.8	1.3	-0.2
Shortness of breath walking on level ground	0.2	0.2	0.5	0.3	-0.7	-0.3	0.4
Qualifications: College or University degree	0.2	0.6	1.9	-1.4	-0.3	-0.2	0.7
Eye problems/disorders: None of the above	0.8	0.9	1.7	0.5	-1.3	-1.3	-0.2
Mouth/teeth dental problems: Loose teeth	1.3	1.6	5.4	-1.0	0.3	-0.0	-2.3
Emphysema/chronic bronchitis	1.7	1.9	4.2	-1.0	-1.0	-1.1	2.1
Medication for pain relief, constipation, heartburn	0.5	0.8	1.7	-1.3	-1.0	-0.6	0.5
Neck or shoulder pain in last month	0.8	1.2	4.0	0.1	-0.7	-0.5	-2.0
Medication: Blood pressure	0.7	1.3	2.0	0.4	-1.1	-1.3	-1.4
Angina (self-reported)	0.7	0.9	1.5	-0.8	1.0	0.7	1.2
Migraine (self-reported)	1.3	1.6	3.0	0.7	1.7	1.6	0.8
Medication: Ibuprofen	0.6	0.8	2.6	1.6	0.1	-0.0	-0.6
Medication: Allopurinol	2.1	2.8	4.2	-0.4	-1.9	-1.8	-2.1
Medication: Omeprazole	0.3	0.3	0.9	-0.6	0.1	0.1	0.9
Medication: Seretide 50 evohaler	0.6	0.7	2.5	-1.6	0.1	-0.2	0.6
Mean time to correctly identify matches	0.6	1.1	1.7	1.3	-1.1	-1.0	-0.6
Heart disease (mother)	1.0	1.2	2.9	-0.6	-1.7	-1.1	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	0.9	-0.3	0.8	0.9	-0.8
Whole body fat mass	0.4	1.5	4.4	-2.1	-1.0	-0.9	0.3
Leg fat mass (right)	0.2	0.9	3.0	-1.7	-0.5	-0.6	0.4
Arm predicted mass (right)	0.2	0.8	2.4	-1.6	-0.2	-0.7	0.6
Pulse rate, automated reading	0.3	1.0	2.0	0.0	-1.3	-0.6	-1.4
Alcohol intake frequency.	0.8	1.9	3.3	-0.3	-1.8	-1.6	-1.2
Comparative height size at age 10	0.2	0.9	2.3	-0.9	0.5	0.2	1.5
Number of full sisters	0.4	0.5	1.3	1.1	-0.2	0.0	-0.7
Suffer from ‘nerves’	0.4	0.6	0.8	0.8	0.6	0.7	0.9
Overall health rating	0.9	2.0	3.4	1.4	1.5	1.9	0.4
Chest pain or discomfort	0.1	0.2	0.6	0.8	-0.2	-0.2	0.3
Had major operations	0.1	0.2	0.6	0.4	0.1	0.1	0.7
Age at last live birth	0.2	0.2	0.6	0.2	-0.4	-0.8	0.4
Family relationship satisfaction	0.7	0.9	3.4	-0.1	-0.0	-0.3	1.8
Leg pain on walking	1.0	1.3	3.0	0.9	1.0	1.7	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.9	1.0	-0.7	-0.4	0.0
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.3	0.0	0.5	0.5	0.3
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.9	-2.0	-1.0	-0.4	-1.1
Medication: Aspirin	0.2	0.3	0.8	-0.4	0.1	0.2	0.9
Supplements: Vitamin C	0.8	0.9	2.0	0.2	1.4	1.3	-0.0
Knee pain experienced in last month	0.8	1.2	2.5	-1.6	-0.5	-0.3	-1.4
Hypertension (Self-reported)	0.2	0.6	1.3	0.7	-0.6	-0.7	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.1	-1.0	0.3	0.4	-0.5
Illnesses of father: Heart disease	0.7	0.9	1.8	-0.9	0.8	0.7	-1.4
Illnesses of siblings: Diabetes	0.4	0.5	1.8	0.2	-0.3	-0.1	-1.3
Smoking status: Previous	0.2	0.3	0.6	0.6	0.7	0.8	0.1
Forced expiratory volume in 1-second (FEV1), predicted	2.4	5.0	8.6	-0.4	2.8	2.9	1.8
Whole body fat-free mass	0.2	1.4	4.8	-2.2	0.1	-0.4	0.7
Leg fat-free mass (right)	0.3	1.5	4.8	-2.2	-0.5	-0.9	0.0
Arm fat percentage (left)	0.4	1.7	5.5	-2.4	-0.8	-0.5	-0.5
Average weekly red wine intake	0.3	0.4	1.3	-0.6	0.3	0.1	1.1
Handedness (chirality/laterality): Left-handed	0.9	1.1	4.0	0.1	-0.1	0.6	2.0
Mood swings	0.5	0.8	1.6	0.3	1.2	1.2	-0.2
Loneliness, isolation	1.8	2.5	3.7	-1.7	1.9	1.8	0.2
Long-standing illness, disability or infirmity	0.1	0.1	0.3	-0.0	-0.4	-0.3	0.5
Ever had bowel cancer screening	0.7	0.8	1.8	-1.3	0.9	0.7	0.3
Diabetes diagnosed by doctor	0.1	0.1	0.2	-0.3	-0.0	-0.2	0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.1	4.5	2.1	-0.2	-0.1	-0.2
Friendships satisfaction	0.5	0.7	1.3	0.8	-0.7	-0.5	1.2
Qualifications: nursing, teaching	0.4	0.7	1.8	-1.3	0.2	-0.5	0.7
Commuting to job workplace: Walk	0.2	0.2	0.5	0.1	-0.7	-0.6	-0.1
Eye problems/disorders: Cataract	1.9	2.2	3.0	-0.7	1.5	1.7	-1.7
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.5	0.7	-0.6	-0.3	-0.4
Medication for cholesterol	0.6	1.0	1.6	-0.9	-1.2	-1.3	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.1	-0.3	-0.5	-1.0	-0.7
Back pain experienced in last month	0.8	1.2	2.5	0.8	-1.1	-1.6	-0.7
Mineral and other dietary supplements	1.3	1.7	3.3	-0.2	1.8	1.7	-0.8
Breast cancer (self-reported)	0.6	0.7	1.5	0.8	-0.6	-0.7	1.2
Asthma (self-reported)	0.4	0.8	2.9	-0.6	-0.1	0.1	1.7
Osteoporosis (self-reported)	0.7	0.9	1.4	1.0	0.7	0.8	1.2
Osteoarthritis (self-reported)	0.9	1.2	3.2	0.7	0.3	1.0	-1.8
Medication: Aspirin	0.3	0.4	1.6	-0.0	0.1	0.1	1.2
Medication: Gliclazide	0.4	0.4	1.0	0.5	-0.5	-1.0	-0.5
Illnesses of father: None of the above (group 1)	0.1	0.2	0.4	0.1	0.4	0.7	-0.1
Smoking status: Current	0.5	0.8	2.3	-0.4	0.7	0.4	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.5	1.0	1.0	0.5	0.9	-0.3
Whole body water mass	0.2	1.2	4.3	-2.1	0.1	-0.4	0.6
Leg predicted mass (right)	0.3	1.5	4.8	-2.2	-0.5	-0.9	-0.0
Arm fat mass (left)	0.3	1.2	4.6	-2.2	-0.4	-0.3	-0.1
Number of self-reported non-cancer illnesses	0.1	0.1	0.3	0.6	0.1	0.0	0.0
Average weekly champagne plus white wine intake	0.5	0.6	2.3	0.4	0.1	-0.3	1.5
Miserableness	1.1	2.0	3.3	-1.7	0.9	0.9	-1.8
Guilty feelings	0.3	0.5	0.9	0.2	0.8	0.6	-1.0
Wears glasses or contact lenses	2.6	3.0	6.7	-0.4	-2.3	-2.6	0.1
Ever taken oral contraceptive pill	0.5	0.6	1.3	0.2	0.9	1.2	-0.2
Hearing aid user	0.4	0.4	1.5	1.2	0.2	-0.2	0.4
Mother’s age at death	0.3	0.3	0.5	-0.4	-0.7	-0.3	0.7
Financial situation satisfaction	0.5	0.6	2.2	1.5	0.3	0.0	-0.5
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	-0.2	0.1	0.3	0.6
Commuting to job workplace: Public transport	0.6	0.7	2.1	-0.7	-0.3	-0.5	1.4
Eye problems/disorders: Glaucoma	0.4	0.5	1.1	-0.3	0.6	0.6	1.1
Medication: Blood pressure	0.4	0.7	1.9	-0.5	0.6	0.4	-1.4
Pain type(s) experienced in last month: Hip pain	1.9	2.4	3.5	-0.6	-1.9	-1.6	-1.8
Supplements: Fish oil (including cod liver oil)	0.7	0.9	3.4	-0.2	-0.2	-0.3	1.9
High cholesterol (Self-reported)	0.4	0.7	2.6	1.6	-0.4	-0.3	-0.3
Medication: Bendroflumethiazide	0.4	0.6	0.9	0.9	0.4	0.9	-0.8
Medication: Paracetamol	1.0	1.6	4.0	2.0	0.2	0.2	-1.5
Medication: Lisinopril	0.2	0.3	0.5	0.4	-0.7	-0.6	-0.2
Medication: Atorvastatin	0.7	0.9	1.2	-1.1	1.0	1.0	0.7
Illnesses of father: High blood pressure	0.2	0.3	0.5	0.5	-0.3	-0.7	0.5
Alcohol drinker status: Never	1.1	1.4	2.5	-0.7	-1.6	-1.5	-0.4
Ever smoked	0.8	1.5	3.0	0.6	1.7	1.5	-0.4
Basal metabolic rate	0.3	1.4	4.9	-2.2	0.0	-0.5	0.7
Leg fat percentage (left)	0.1	0.4	1.0	-1.0	-0.3	-0.1	0.7
Arm fat-free mass (left)	0.2	0.8	2.9	-1.7	0.1	-0.4	0.5
Number of operations (self-reported)	1.0	1.5	2.9	0.7	1.6	1.7	0.7
Average weekly beer plus cider intake	1.1	1.6	3.0	-1.0	-1.7	-1.5	-0.0
Irritability	0.1	0.1	0.3	-0.5	-0.1	0.1	-0.5
Risk taking	1.0	1.4	3.0	-1.7	-1.4	-0.7	-0.0
Ever had prostate specific antigen (PSA) test	1.2	1.3	2.5	-0.2	-1.4	-1.6	1.0
Fractured/broken bones in last 5 years	0.8	1.1	3.2	-1.1	0.3	0.1	1.8
Age started oral contraceptive pill	2.2	2.7	4.8	-0.6	-2.1	-2.2	-1.2
Diastolic blood pressure, automated reading	1.0	3.0	6.6	-0.6	-2.2	-2.6	-0.6
Ever depressed for a whole week	1.4	1.7	3.8	-0.0	-1.7	-1.9	-0.2
Unable to work because of sickness or disability	0.4	0.6	1.0	-1.0	0.5	0.8	-0.6
Commuting to job workplace: Cycle	1.0	1.2	4.1	0.5	0.6	0.3	-2.0
Myopia	0.1	0.2	0.5	-0.7	0.4	0.3	-0.2
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.8	-0.9	-0.2	0.1	0.6
Cholesterol lowering medication	0.1	0.1	0.3	0.6	0.4	0.1	0.1
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.5	-0.1	0.8	0.6	1.2
Pain experienced in last month	0.3	0.5	1.2	0.9	0.1	0.2	1.1
Supplements: Calcium	0.4	0.5	1.2	1.1	-0.7	-0.4	-0.0
Basal cell carcinoma (self-reported)	0.2	0.2	0.7	-0.8	0.2	0.2	0.4
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.7	-1.3	0.7	0.8	0.4
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.3	0.6	0.5	1.5	-1.1
Heart disease (siblings)	0.4	0.5	1.8	-0.5	0.2	0.2	-1.3
Alcohol drinker status: Previous	0.4	0.5	1.1	1.1	0.4	0.6	-0.5
Pack years of smoking	0.2	0.3	0.5	-0.7	-0.3	-0.7	0.5
Impedance of whole body	0.4	1.8	5.4	2.3	0.6	0.6	1.0
Leg fat mass (left)	0.2	0.9	2.9	-1.7	-0.7	-0.7	0.2
Arm predicted mass (left)	0.2	0.8	2.8	-1.7	0.4	-0.1	0.5