Hub : Genes

RAB37

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.212 0.044 1.1e-08 0.213 0.118 0.214 0.215 0.218 2.0e-25 3.5e-14 1.3e-25 9.6e-26 4.2e-26
2 GTEx Brain Cerebellar Hemisphere 0.364 0.111 1.4e-03 0.170 NA 0.028 NA 0.126 4.0e-05 NA 6.3e-02 NA 4.0e-04
3 GTEx Brain Cerebellum 0.319 0.104 2.2e-03 0.357 NA 0.318 NA 0.366 2.1e-11 NA 4.0e-10 NA 9.6e-12
4 GTEx Testis 0.266 0.085 1.0e-03 0.199 NA 0.152 NA 0.164 3.2e-09 NA 2.9e-07 NA 9.5e-08

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.2 0.3 0.9 -0.2 -0.3 -1.0 0.0
Bipolar Disorder or Schizophrenia 0.0 0.1 0.2 -0.4 0.4 -0.1 -0.1
Depressed Affect (Nagel 2018) 0.7 1.5 2.9 -1.2 1.1 0.7 -1.7
Depression (Nagel 2018) 0.4 0.6 1.1 1.0 1.0 0.5 -0.4
Intelligence (Savage-Jansen 2018) 0.2 0.7 1.8 1.3 -0.7 -0.4 0.7
Neuroticism (Nagel 2018) 0.3 0.8 1.4 -0.4 1.1 0.7 -1.2
Schizophrenia (2018) 0.1 0.3 0.6 -0.3 0.8 0.7 -0.2
Schizophrenia vs Biploar Disorder 0.9 1.2 3.4 0.3 -0.5 -1.0 -1.9
Worry (Nagel 2018) 0.1 0.2 0.4 0.6 -0.2 -0.4 -0.2
Alzheimer’s Disease (in mother) 0.5 0.6 1.3 -0.6 0.6 0.7 -1.1
Alzheimer’s Disease (in father) 0.9 1.0 2.6 1.6 -0.8 -0.6 0.3
Alzheimer’s Disease (including proxy) 0.8 1.2 3.3 1.0 -0.7 -0.3 -1.8
Crohns Disease (2017) 0.1 0.2 0.6 0.8 -0.2 0.1 0.1
Irritable Bowel Disease (IBD) 0.1 0.3 0.7 0.6 -0.2 -0.0 0.8
Ulcerative Colitis (UC) 0.4 0.7 2.2 0.7 -0.2 -0.1 1.5
Major Depression (MDD) 0.7 0.8 2.3 -0.2 1.0 1.5 0.0
Reaction Time 0.2 0.3 0.7 0.4 -0.6 -0.3 -0.8
Verbal and Numeric Reasoning (VNR) 0.5 1.3 3.1 0.8 -0.9 -0.8 1.8
Breast Cancer 1.3 3.1 10.4 0.9 -0.9 -0.7 -3.2
Ovarian Cancer 1.7 2.3 8.4 2.9 -0.6 -0.5 -0.4
Prostate Cancer 1.4 1.9 3.5 -0.4 -1.4 -1.9 -1.4
Age at First Birth 0.6 0.9 1.5 -0.5 1.2 1.1 0.6
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.0 0.0 0.1 -0.1 0.0 -0.4 0.1
Coronary Artery Disease (CAD) 0.6 0.7 1.5 -0.3 -0.5 -0.9 -1.2
Crohns Disease (2012) 0.0 0.0 0.1 -0.3 0.3 0.0 0.0
Mean Putamen Volume 1.3 1.5 3.0 1.7 0.3 0.8 -1.4
Fasting Glucose 0.5 0.5 1.1 -0.1 -1.1 -0.5 0.9
HbA1C 0.6 0.7 1.3 -0.1 0.5 1.1 1.2
HDL Cholesterol 0.4 0.7 2.2 1.5 -0.5 -0.1 -0.6
LDL Cholesterol 1.0 1.6 3.2 -0.0 -1.8 -1.6 0.8
Lupus 0.2 0.3 0.6 0.2 0.8 0.7 0.5
Neuroticism (2016) 0.7 1.1 1.9 -1.4 0.9 1.2 0.4
Primary Biliary Cirrhosis 0.7 1.0 2.8 0.7 0.0 0.8 1.7
Rheumatoid Arthritis 0.8 1.1 2.1 -1.5 -1.2 -0.9 -0.3
Schizophrenia (2014) 0.1 0.2 0.6 -0.4 -0.1 -0.2 -0.8
Triglycerides 0.6 1.0 2.1 -0.5 -1.3 -1.4 0.4
Type 2 Diabetes (T2D) (2012) 1.2 1.4 4.7 -0.5 -0.5 -0.6 -2.2
Ulcerative Colitis 0.2 0.4 1.0 0.0 -0.6 -1.0 -0.3
Blood Eosinophil Count 0.4 2.7 3.6 -1.9 -1.6 -1.6 1.5
Blood Platelet Count 0.5 5.6 16.2 1.9 1.0 1.1 4.0
Blood Red Count 0.1 1.3 5.1 0.3 -0.1 -0.2 2.3
Blood White Count 1.9 13.9 54.3 1.0 -0.0 0.6 -7.4
Heel T-Score 0.4 3.2 12.4 -0.4 -0.2 -0.3 -3.5
BMI 0.5 2.9 6.8 -2.6 -1.7 -1.4 0.1
Height 0.1 2.4 5.3 -2.3 0.7 0.5 1.8
Waist Hip Ratio (WHR) 0.1 0.3 0.9 0.9 0.3 -0.1 0.2
Systolic Blood Pressure 0.2 0.8 2.7 1.6 0.4 0.1 -0.7
Smoking Status 0.7 1.8 2.6 -1.1 1.4 1.1 -1.6
Allergy or Eczema 1.3 3.5 11.6 -1.5 -0.1 0.3 3.4
Cardiovascular Disease 0.2 0.7 1.4 1.1 0.4 0.4 -1.2
Hypothyroidism (self reported) 0.4 1.0 2.2 0.1 0.8 1.0 -1.5
Respiratory disease 0.8 1.7 4.9 -0.8 -0.8 -0.9 2.2
Type 2 Diabetes (T2D) (2018) 0.3 0.6 2.2 0.1 -0.5 -0.1 -1.5
Lung FEV1/FVC ratio 0.5 2.3 4.0 0.2 1.2 2.0 -2.0
Lung FVC 0.1 0.3 0.5 0.7 -0.4 -0.6 -0.1
Neuroticism 0.4 1.0 1.2 -1.0 1.1 0.7 -1.1
Chronotype (morning person) 0.4 0.8 1.9 1.4 0.5 0.9 0.5
Hair Pigment 0.0 1.0 1.8 -0.5 1.1 1.3 0.9
Tanning 0.0 0.2 0.3 -0.4 -0.2 0.3 0.5
Hand grip strength (left) 1.0 2.6 6.0 -1.5 1.3 0.7 2.4
Number of treatments/medications taken 1.4 2.6 8.5 2.9 0.0 -0.2 -1.4
Average weekly spirits intake 0.6 0.7 1.4 0.6 -1.2 -1.1 -0.2
Sensitivity / hurt feelings 0.9 1.5 2.5 -0.6 1.6 1.5 -1.0
Frequency of depressed mood in last 2 weeks 1.6 2.2 3.3 1.8 1.8 1.6 0.0
Hearing difficulty/problems: Yes 0.6 1.0 1.6 -1.1 -1.2 -1.1 0.0
Relative age of first facial hair 0.1 0.3 0.9 -1.0 0.1 0.3 -0.1
Other serious medical condition/disability diagnosed by doctor 0.0 0.0 0.1 0.2 0.2 0.2 0.0
Ever used hormone-replacement therapy (HRT) 0.4 0.6 1.1 1.0 0.8 0.6 -0.4
Ever had hysterectomy (womb removed) 0.0 0.0 0.1 -0.2 -0.2 0.1 0.2
Systolic blood pressure, automated reading 0.7 2.2 4.5 -0.8 -1.9 -2.1 -0.4
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.2 -0.5 -0.2 -0.2 -0.0
Angina 1.0 1.3 1.9 -0.7 1.4 1.1 1.2
Medication for hormone replacement therapy 1.8 2.0 6.0 2.5 -0.4 0.2 1.4
Vitamin and mineral supplements 0.5 0.7 1.7 -1.3 -0.5 -0.4 -0.9
Supplements: Zinc 0.4 0.4 0.9 0.4 0.5 0.5 0.9
Medication: Co-codamol 0.1 0.1 0.3 -0.4 -0.6 -0.2 -0.2
Medication: Metformin 0.0 0.0 0.1 -0.2 0.0 0.0 0.2
Diabetes (father) 0.0 0.1 0.1 0.1 0.2 0.3 -0.3
Diabetes (mother) 0.7 1.0 1.6 -0.3 -0.9 -1.1 -1.2
Severe depression (siblings) 1.5 1.7 6.0 0.2 0.7 0.5 2.5
Pack years adult smoking proportion 0.3 0.4 0.8 -0.9 0.0 -0.4 0.9
Impedance of leg (right) 0.8 4.1 8.4 2.9 1.3 1.1 2.3
Leg fat-free mass (left) 0.3 1.7 5.3 -2.3 -0.6 -1.1 0.1
Trunk fat percentage 0.4 1.7 3.1 -1.8 -1.5 -1.3 -0.1
Hand grip strength (right) 0.5 1.3 3.3 -0.6 1.2 0.4 1.8
Townsend deprivation index at recruitment 1.1 1.6 4.2 2.0 -0.4 0.2 -1.4
Current tobacco smoking 0.8 1.2 4.4 -0.3 0.6 0.3 -2.1
Average weekly fortified wine intake 0.7 0.8 1.5 -0.5 1.0 1.2 0.7
Maternal smoking around birth 0.3 0.4 0.9 -1.0 0.2 0.5 0.8
Fed-up feelings 0.9 1.5 2.1 0.8 1.4 1.3 -1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.4 3.0 1.7 1.1 1.1 -0.5
Relative age voice broke 0.3 0.5 1.6 1.3 0.1 0.4 0.3
Taking other prescription medications 0.3 0.5 1.0 0.2 -1.0 -0.7 -0.7
Age when periods started (menarche) 0.7 1.6 6.2 2.5 -0.2 0.1 -0.5
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.3 -0.3 -0.4 -0.6 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.4 1.0 1.5 -0.2 -1.2 -1.0 -1.1
Tinnitus: Yes, but not now, but have in the past 2.0 2.1 6.2 -0.0 0.6 1.4 2.5
Qualifications: CSEs or equivalent 0.3 0.4 1.4 0.2 0.3 0.5 -1.2
Serious illness, injury or assault to yourself 0.5 0.6 1.7 -0.0 1.3 1.0 0.1
High blood pressure 0.3 0.8 1.4 1.2 -0.4 -0.5 -1.2
Hayfever, allergic rhinitis or eczema 2.1 4.5 14.1 -1.9 0.0 0.4 3.8
Multivitamins +/- minerals 0.2 0.3 0.7 0.7 0.1 0.1 0.8
Stomach or abdominal pain in last month 1.2 1.5 2.6 0.9 1.6 1.3 1.0
Supplements: Glucosamine 0.4 0.5 1.2 -0.7 -0.6 -0.2 1.1
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 0.7 0.6 -0.5 -0.8 -0.1
Medication: Atenolol 0.7 0.9 1.7 -1.3 -0.4 -0.8 1.0
Medication: Levothyroxine sodium 1.5 2.5 7.3 2.7 0.5 0.9 -1.3
Sitting height 0.1 0.5 1.5 -0.5 -0.1 -0.5 1.2
Chronic bronchitis/emphysema (father) 1.1 1.3 2.5 -0.0 1.0 1.3 1.6
High blood pressure (mother) 1.2 1.7 3.8 1.0 -1.4 -1.9 -0.1
Body mass index (BMI) 0.4 1.8 5.7 -2.4 -0.8 -0.7 -0.5
Impedance of leg (left) 0.9 4.3 9.7 3.1 1.2 1.1 2.2
Leg predicted mass (left) 0.3 1.7 5.4 -2.3 -0.6 -1.1 0.1
Trunk fat mass 0.5 2.0 5.0 -2.2 -1.2 -1.2 0.2
Waist circumference 0.3 1.0 2.4 -1.5 -0.8 -1.0 0.1
Number of incorrect matches in round 0.3 0.5 1.2 -0.5 -0.8 -1.1 0.3
Past tobacco smoking 0.7 1.3 2.5 -0.5 -1.6 -1.6 -0.2
Alcohol usually taken with meals 0.4 0.6 1.5 -0.1 -1.2 -1.0 -0.4
Nervous feelings 1.1 2.1 3.9 2.0 1.5 1.5 -0.3
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.3 2.4 -0.3 1.3 1.5 0.9
Hearing difficulty/problems with background noise 0.6 0.9 3.5 -1.9 0.2 -0.1 -0.2
Hair/balding pattern: Pattern 2 1.0 1.2 3.0 -0.2 1.7 1.2 0.7
Had menopause 0.2 0.3 0.7 -0.4 0.3 0.8 -0.6
Had other major operations 0.1 0.1 0.3 -0.1 0.6 0.3 0.3
Forced vital capacity (FVC) 0.2 0.6 1.4 0.7 1.2 0.6 0.5
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.9 2.0 -0.7 -0.9 -0.7 -1.4
Ever unenthusiastic/disinterested for a whole week 0.3 0.3 0.6 0.4 -0.8 -0.7 0.2
Qualifications: None of the above 0.6 1.3 3.8 -0.4 0.6 0.9 -1.9
Financial difficulties in last 2 years 0.9 1.2 2.5 1.6 1.1 0.6 -0.8
Mouth/teeth dental problems 0.5 0.7 2.7 0.2 -0.2 -0.2 1.6
Heart attack 0.8 1.0 2.0 -1.4 0.8 0.9 0.8
Allergy 1.4 3.1 10.2 1.4 -0.0 -0.4 -3.2
Pain all over the body in last month 1.9 2.0 2.9 0.3 1.4 1.7 -1.7
Diabetes (self-reported) 0.1 0.2 0.3 -0.1 -0.5 -0.5 -0.4
Hayfever/allergic rhinitis (self-reported) 1.2 1.5 2.5 0.4 1.3 1.6 1.4
Medication: Ramipril 0.4 0.5 0.8 0.8 -0.6 -0.9 -0.5
Medication: Simvastatin 0.3 0.5 1.1 1.1 0.6 0.4 -0.5
Fluid intelligence score 0.2 0.4 0.5 0.7 -0.7 -0.5 0.6
Illnesses of siblings 1.3 1.9 5.6 2.4 -0.2 -0.5 1.3
Neuroticism score 0.5 1.0 2.2 -0.2 1.5 1.3 -0.3
Weight 0.3 1.6 5.7 -2.4 -0.3 -0.6 0.6
Impedance of arm (right) 0.2 1.0 2.6 1.6 0.8 0.9 0.3
Arm fat percentage (right) 0.4 1.6 5.8 -2.4 -0.7 -0.4 -0.3
Trunk fat-free mass 0.2 1.3 3.3 -1.8 0.6 0.2 1.2
Hip circumference 0.3 1.2 3.0 -1.7 -0.9 -0.9 0.4
Time employed in main current job 0.4 0.4 0.6 0.8 -0.8 -0.6 -0.1
Alcohol intake versus 10 years previously 0.5 0.7 1.2 -0.3 -1.1 -1.1 0.6
Father’s age at death 1.0 1.4 1.8 1.2 -1.1 -1.3 1.0
Worrier / anxious feelings 0.2 0.4 0.8 -0.9 0.3 0.4 -0.9
Frequency of tiredness / lethargy in last 2 weeks 1.1 1.8 2.7 1.6 1.4 1.6 0.0
Falls in the last year 1.1 1.5 2.5 1.6 1.0 1.5 0.3
Hair/balding pattern: Pattern 3 0.8 1.1 2.1 0.1 -1.4 -1.0 -1.2
Number of live births 0.2 0.2 0.9 -0.1 -0.0 0.1 -1.0
Forced expiratory volume in 1-second (FEV1) 0.1 0.2 0.5 0.3 0.7 0.3 0.1
Pulse rate 1.1 1.9 3.6 0.3 -1.9 -1.2 -1.5
Happiness 0.2 0.3 0.8 0.1 -0.3 -0.4 0.9
Noisy workplace 2.6 3.3 7.4 -0.1 2.2 2.7 -0.9
Qualifications: A levels/AS levels or equivalent 0.7 1.5 4.7 1.0 0.6 -0.3 2.2
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 1.1 0.5 -0.5 -1.1 0.9
Mouth/teeth dental problems: Dentures 0.7 1.1 3.9 0.5 0.2 0.6 -2.0
Asthma 0.4 0.7 2.3 -0.8 -0.1 0.0 1.5
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.8 1.4 0.5 0.1 0.0
Medication: Cholesterol lowering 0.1 0.1 0.3 0.6 -0.2 -0.1 0.1
Depression (self-reported) 0.1 0.1 0.4 -0.0 0.7 0.1 0.2
Medication: Lansoprazole 0.3 0.3 0.6 0.1 0.6 0.8 -0.5
Prospective memory result 0.6 0.8 2.1 1.0 0.2 -0.1 -1.4
Lung cancer (father) 2.4 2.8 6.3 0.1 -1.6 -1.5 -2.5
Illnesses of mother 1.0 1.2 2.6 -0.8 1.6 1.3 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.0 0.1 0.2 0.4 0.5 0.1 0.5
Pulse wave Arterial Stiffness index 1.3 1.5 4.1 1.1 -0.6 -0.6 -2.0
Impedance of arm (left) 0.2 0.7 2.0 1.4 0.5 0.7 0.4
Arm fat mass (right) 0.4 1.5 4.8 -2.2 -0.7 -0.7 -0.3
Trunk predicted mass 0.2 1.2 3.1 -1.8 0.7 0.3 1.1
Standing height 0.2 2.1 6.3 -0.5 1.2 0.4 2.5
Length of working week for main job 1.1 1.2 2.9 -0.6 1.1 1.7 0.4
Exposure to tobacco smoke at home 0.2 0.2 0.6 -0.8 -0.4 -0.2 0.2
Breastfed as a baby 0.6 0.7 1.5 1.2 -0.0 -0.0 1.2
Tense / ‘highly strung’ 0.6 1.0 2.1 1.2 -0.6 -0.6 1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.7 1.7 1.3 0.7 0.7 0.2
Hair/balding pattern: Pattern 4 0.2 0.5 0.7 -0.8 -0.9 -0.4 -0.6
Birth weight of first child 1.3 2.4 7.1 -2.7 -0.7 -1.2 -0.9
Peak expiratory flow (PEF) 0.2 0.4 0.8 -0.8 0.2 -0.1 0.9
Pulse wave reflection index 1.1 1.4 4.8 0.3 -0.6 -0.7 -2.2
Ever highly irritable/argumentative for 2 days 1.6 1.9 2.7 -1.0 -1.6 -1.3 -1.6
Loud music exposure frequency 0.4 0.4 0.7 0.4 -0.8 -0.5 -0.8
Qualifications: O levels/GCSEs or equivalent 0.3 0.6 1.1 1.1 -0.3 -0.6 0.7
Mouth/teeth dental problems: Bleeding gums 0.3 0.3 0.8 -0.9 -0.0 -0.5 -0.5
Blood clot in the leg (DVT) 0.7 0.9 2.4 0.6 0.6 1.5 -0.8
Medication: Paracetamol 1.0 1.6 3.7 1.9 1.1 0.5 -1.1
Headache pain in last month 0.2 0.4 1.3 -1.2 0.1 -0.2 -0.5
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 0.7 0.2 0.8 0.8 0.7
Glaucoma (self-reported) 0.8 1.0 2.3 -0.4 -0.9 -0.7 1.5
Gout (self-reported) 1.2 1.7 3.6 -1.3 -0.8 -0.9 -1.9
Hypothyroidism/myxoedema (self-reported) 1.1 2.2 3.2 1.8 1.1 1.5 -1.5
Medication: Amlodipine 0.4 0.6 1.4 0.5 0.5 0.6 -1.2
Medication: Ventolin 100micrograms inhaler 0.2 0.3 0.9 -0.0 -0.9 -0.5 0.3
Birth weight 0.4 0.8 2.0 -0.6 -0.6 -1.4 0.8
Chronic bronchitis/emphysema (mother) 1.4 1.6 4.3 -2.1 0.7 1.2 0.7
High blood pressure (siblings) 0.6 0.9 2.4 -1.6 0.3 0.5 0.8
Forced vital capacity (FVC), Best measure 0.2 0.7 1.1 0.6 1.1 0.6 0.9
Body fat percentage 0.4 1.5 3.8 -2.0 -1.1 -0.9 0.1
Leg fat percentage (right) 0.1 0.4 1.1 -1.0 -0.1 0.0 0.8
Arm fat-free mass (right) 0.2 1.1 3.2 -1.8 -0.3 -0.9 0.6
Exposure to tobacco smoke outside home 1.1 1.4 5.0 2.2 0.3 0.6 -0.5
Comparative body size at age 10 0.5 1.4 2.1 -1.5 1.1 1.4 -0.4
Number of full brothers 0.5 0.6 1.4 0.5 -0.9 -0.5 1.2
Worry too long after embarrassment 0.6 1.1 2.9 0.1 1.7 1.1 0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 1.4 1.9 3.5 -1.1 1.5 1.9 -0.7
Wheeze or whistling in the chest in last year 0.6 1.0 3.0 -1.7 -0.4 -0.4 -0.9
Number of children fathered 1.4 1.6 3.9 -2.0 1.1 0.8 0.9
Reason for reducing amount of alcohol drunk: Health precaution 1.7 2.0 4.1 -1.9 0.0 -0.4 2.0
Age at first live birth 0.6 1.1 3.4 1.8 -0.5 -0.8 0.4
Pulse wave peak to peak time 2.1 2.5 6.5 -1.3 0.9 0.8 2.5
Health satisfaction 0.5 0.6 1.6 0.4 0.8 1.3 -0.2
Shortness of breath walking on level ground 0.2 0.2 0.5 0.3 -0.7 -0.3 0.4
Qualifications: College or University degree 0.2 0.6 1.9 -1.4 -0.3 -0.2 0.7
Eye problems/disorders: None of the above 0.8 0.9 1.7 0.5 -1.3 -1.3 -0.2
Mouth/teeth dental problems: Loose teeth 1.3 1.6 5.4 -1.0 0.3 -0.0 -2.3
Emphysema/chronic bronchitis 1.7 1.9 4.2 -1.0 -1.0 -1.1 2.1
Medication for pain relief, constipation, heartburn 0.5 0.8 1.7 -1.3 -1.0 -0.6 0.5
Neck or shoulder pain in last month 0.8 1.2 4.0 0.1 -0.7 -0.5 -2.0
Medication: Blood pressure 0.7 1.3 2.0 0.4 -1.1 -1.3 -1.4
Angina (self-reported) 0.7 0.9 1.5 -0.8 1.0 0.7 1.2
Migraine (self-reported) 1.3 1.6 3.0 0.7 1.7 1.6 0.8
Medication: Ibuprofen 0.6 0.8 2.6 1.6 0.1 -0.0 -0.6
Medication: Allopurinol 2.1 2.8 4.2 -0.4 -1.9 -1.8 -2.1
Medication: Omeprazole 0.3 0.3 0.9 -0.6 0.1 0.1 0.9
Medication: Seretide 50 evohaler 0.6 0.7 2.5 -1.6 0.1 -0.2 0.6
Mean time to correctly identify matches 0.6 1.1 1.7 1.3 -1.1 -1.0 -0.6
Heart disease (mother) 1.0 1.2 2.9 -0.6 -1.7 -1.1 0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 0.9 -0.3 0.8 0.9 -0.8
Whole body fat mass 0.4 1.5 4.4 -2.1 -1.0 -0.9 0.3
Leg fat mass (right) 0.2 0.9 3.0 -1.7 -0.5 -0.6 0.4
Arm predicted mass (right) 0.2 0.8 2.4 -1.6 -0.2 -0.7 0.6
Pulse rate, automated reading 0.3 1.0 2.0 0.0 -1.3 -0.6 -1.4
Alcohol intake frequency. 0.8 1.9 3.3 -0.3 -1.8 -1.6 -1.2
Comparative height size at age 10 0.2 0.9 2.3 -0.9 0.5 0.2 1.5
Number of full sisters 0.4 0.5 1.3 1.1 -0.2 0.0 -0.7
Suffer from ‘nerves’ 0.4 0.6 0.8 0.8 0.6 0.7 0.9
Overall health rating 0.9 2.0 3.4 1.4 1.5 1.9 0.4
Chest pain or discomfort 0.1 0.2 0.6 0.8 -0.2 -0.2 0.3
Had major operations 0.1 0.2 0.6 0.4 0.1 0.1 0.7
Age at last live birth 0.2 0.2 0.6 0.2 -0.4 -0.8 0.4
Family relationship satisfaction 0.7 0.9 3.4 -0.1 -0.0 -0.3 1.8
Leg pain on walking 1.0 1.3 3.0 0.9 1.0 1.7 0.6
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 0.9 1.0 -0.7 -0.4 0.0
Commuting to job workplace: Car/motor vehicle 0.1 0.2 0.3 0.0 0.5 0.5 0.3
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 3.9 -2.0 -1.0 -0.4 -1.1
Medication: Aspirin 0.2 0.3 0.8 -0.4 0.1 0.2 0.9
Supplements: Vitamin C 0.8 0.9 2.0 0.2 1.4 1.3 -0.0
Knee pain experienced in last month 0.8 1.2 2.5 -1.6 -0.5 -0.3 -1.4
Hypertension (Self-reported) 0.2 0.6 1.3 0.7 -0.6 -0.7 -1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 1.1 -1.0 0.3 0.4 -0.5
Illnesses of father: Heart disease 0.7 0.9 1.8 -0.9 0.8 0.7 -1.4
Illnesses of siblings: Diabetes 0.4 0.5 1.8 0.2 -0.3 -0.1 -1.3
Smoking status: Previous 0.2 0.3 0.6 0.6 0.7 0.8 0.1
Forced expiratory volume in 1-second (FEV1), predicted 2.4 5.0 8.6 -0.4 2.8 2.9 1.8
Whole body fat-free mass 0.2 1.4 4.8 -2.2 0.1 -0.4 0.7
Leg fat-free mass (right) 0.3 1.5 4.8 -2.2 -0.5 -0.9 0.0
Arm fat percentage (left) 0.4 1.7 5.5 -2.4 -0.8 -0.5 -0.5
Average weekly red wine intake 0.3 0.4 1.3 -0.6 0.3 0.1 1.1
Handedness (chirality/laterality): Left-handed 0.9 1.1 4.0 0.1 -0.1 0.6 2.0
Mood swings 0.5 0.8 1.6 0.3 1.2 1.2 -0.2
Loneliness, isolation 1.8 2.5 3.7 -1.7 1.9 1.8 0.2
Long-standing illness, disability or infirmity 0.1 0.1 0.3 -0.0 -0.4 -0.3 0.5
Ever had bowel cancer screening 0.7 0.8 1.8 -1.3 0.9 0.7 0.3
Diabetes diagnosed by doctor 0.1 0.1 0.2 -0.3 -0.0 -0.2 0.5
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.1 4.5 2.1 -0.2 -0.1 -0.2
Friendships satisfaction 0.5 0.7 1.3 0.8 -0.7 -0.5 1.2
Qualifications: nursing, teaching 0.4 0.7 1.8 -1.3 0.2 -0.5 0.7
Commuting to job workplace: Walk 0.2 0.2 0.5 0.1 -0.7 -0.6 -0.1
Eye problems/disorders: Cataract 1.9 2.2 3.0 -0.7 1.5 1.7 -1.7
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.5 0.7 -0.6 -0.3 -0.4
Medication for cholesterol 0.6 1.0 1.6 -0.9 -1.2 -1.3 0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 1.1 -0.3 -0.5 -1.0 -0.7
Back pain experienced in last month 0.8 1.2 2.5 0.8 -1.1 -1.6 -0.7
Mineral and other dietary supplements 1.3 1.7 3.3 -0.2 1.8 1.7 -0.8
Breast cancer (self-reported) 0.6 0.7 1.5 0.8 -0.6 -0.7 1.2
Asthma (self-reported) 0.4 0.8 2.9 -0.6 -0.1 0.1 1.7
Osteoporosis (self-reported) 0.7 0.9 1.4 1.0 0.7 0.8 1.2
Osteoarthritis (self-reported) 0.9 1.2 3.2 0.7 0.3 1.0 -1.8
Medication: Aspirin 0.3 0.4 1.6 -0.0 0.1 0.1 1.2
Medication: Gliclazide 0.4 0.4 1.0 0.5 -0.5 -1.0 -0.5
Illnesses of father: None of the above (group 1) 0.1 0.2 0.4 0.1 0.4 0.7 -0.1
Smoking status: Current 0.5 0.8 2.3 -0.4 0.7 0.4 -1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.5 1.0 1.0 0.5 0.9 -0.3
Whole body water mass 0.2 1.2 4.3 -2.1 0.1 -0.4 0.6
Leg predicted mass (right) 0.3 1.5 4.8 -2.2 -0.5 -0.9 -0.0
Arm fat mass (left) 0.3 1.2 4.6 -2.2 -0.4 -0.3 -0.1
Number of self-reported non-cancer illnesses 0.1 0.1 0.3 0.6 0.1 0.0 0.0
Average weekly champagne plus white wine intake 0.5 0.6 2.3 0.4 0.1 -0.3 1.5
Miserableness 1.1 2.0 3.3 -1.7 0.9 0.9 -1.8
Guilty feelings 0.3 0.5 0.9 0.2 0.8 0.6 -1.0
Wears glasses or contact lenses 2.6 3.0 6.7 -0.4 -2.3 -2.6 0.1
Ever taken oral contraceptive pill 0.5 0.6 1.3 0.2 0.9 1.2 -0.2
Hearing aid user 0.4 0.4 1.5 1.2 0.2 -0.2 0.4
Mother’s age at death 0.3 0.3 0.5 -0.4 -0.7 -0.3 0.7
Financial situation satisfaction 0.5 0.6 2.2 1.5 0.3 0.0 -0.5
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.3 -0.2 0.1 0.3 0.6
Commuting to job workplace: Public transport 0.6 0.7 2.1 -0.7 -0.3 -0.5 1.4
Eye problems/disorders: Glaucoma 0.4 0.5 1.1 -0.3 0.6 0.6 1.1
Medication: Blood pressure 0.4 0.7 1.9 -0.5 0.6 0.4 -1.4
Pain type(s) experienced in last month: Hip pain 1.9 2.4 3.5 -0.6 -1.9 -1.6 -1.8
Supplements: Fish oil (including cod liver oil) 0.7 0.9 3.4 -0.2 -0.2 -0.3 1.9
High cholesterol (Self-reported) 0.4 0.7 2.6 1.6 -0.4 -0.3 -0.3
Medication: Bendroflumethiazide 0.4 0.6 0.9 0.9 0.4 0.9 -0.8
Medication: Paracetamol 1.0 1.6 4.0 2.0 0.2 0.2 -1.5
Medication: Lisinopril 0.2 0.3 0.5 0.4 -0.7 -0.6 -0.2
Medication: Atorvastatin 0.7 0.9 1.2 -1.1 1.0 1.0 0.7
Illnesses of father: High blood pressure 0.2 0.3 0.5 0.5 -0.3 -0.7 0.5
Alcohol drinker status: Never 1.1 1.4 2.5 -0.7 -1.6 -1.5 -0.4
Ever smoked 0.8 1.5 3.0 0.6 1.7 1.5 -0.4
Basal metabolic rate 0.3 1.4 4.9 -2.2 0.0 -0.5 0.7
Leg fat percentage (left) 0.1 0.4 1.0 -1.0 -0.3 -0.1 0.7
Arm fat-free mass (left) 0.2 0.8 2.9 -1.7 0.1 -0.4 0.5
Number of operations (self-reported) 1.0 1.5 2.9 0.7 1.6 1.7 0.7
Average weekly beer plus cider intake 1.1 1.6 3.0 -1.0 -1.7 -1.5 -0.0
Irritability 0.1 0.1 0.3 -0.5 -0.1 0.1 -0.5
Risk taking 1.0 1.4 3.0 -1.7 -1.4 -0.7 -0.0
Ever had prostate specific antigen (PSA) test 1.2 1.3 2.5 -0.2 -1.4 -1.6 1.0
Fractured/broken bones in last 5 years 0.8 1.1 3.2 -1.1 0.3 0.1 1.8
Age started oral contraceptive pill 2.2 2.7 4.8 -0.6 -2.1 -2.2 -1.2
Diastolic blood pressure, automated reading 1.0 3.0 6.6 -0.6 -2.2 -2.6 -0.6
Ever depressed for a whole week 1.4 1.7 3.8 -0.0 -1.7 -1.9 -0.2
Unable to work because of sickness or disability 0.4 0.6 1.0 -1.0 0.5 0.8 -0.6
Commuting to job workplace: Cycle 1.0 1.2 4.1 0.5 0.6 0.3 -2.0
Myopia 0.1 0.2 0.5 -0.7 0.4 0.3 -0.2
Vascular/heart problems diagnosed by doctor 0.1 0.3 0.8 -0.9 -0.2 0.1 0.6
Cholesterol lowering medication 0.1 0.1 0.3 0.6 0.4 0.1 0.1
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.5 -0.1 0.8 0.6 1.2
Pain experienced in last month 0.3 0.5 1.2 0.9 0.1 0.2 1.1
Supplements: Calcium 0.4 0.5 1.2 1.1 -0.7 -0.4 -0.0
Basal cell carcinoma (self-reported) 0.2 0.2 0.7 -0.8 0.2 0.2 0.4
Heart attack/myocardial infarction (self-reported) 0.6 0.8 1.7 -1.3 0.7 0.8 0.4
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 2.3 0.6 0.5 1.5 -1.1
Heart disease (siblings) 0.4 0.5 1.8 -0.5 0.2 0.2 -1.3
Alcohol drinker status: Previous 0.4 0.5 1.1 1.1 0.4 0.6 -0.5
Pack years of smoking 0.2 0.3 0.5 -0.7 -0.3 -0.7 0.5
Impedance of whole body 0.4 1.8 5.4 2.3 0.6 0.6 1.0
Leg fat mass (left) 0.2 0.9 2.9 -1.7 -0.7 -0.7 0.2
Arm predicted mass (left) 0.2 0.8 2.8 -1.7 0.4 -0.1 0.5