TWAS hub - SLC9A3R1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.2520	0.0960	8.8e-03	0.248	NA	0.196	NA	0.228	6.1e-08	NA	1.9e-06	NA	2.3e-07
2	GTEx	Pancreas	0.2650	0.0880	1.7e-03	-0.006	NA	0.000	NA	-0.002	8.1e-01	NA	3.0e-01	NA	4.0e-01
3	METSIM	Adipose	0.0814	0.0348	1.8e-02	0.076	-0.002	0.068	0.072	0.074	2.0e-11	9.5e-01	2.3e-10	5.7e-11	3.3e-11
4	NTR	Blood	0.0216	0.0091	5.0e-03	0.017	0.006	0.007	0.008	0.015	1.8e-06	3.9e-03	2.4e-03	9.6e-04	1.2e-05
5	YFS	Blood	0.1444	0.0266	5.6e-17	0.036	0.068	0.072	0.072	0.058	8.5e-12	1.9e-21	1.8e-22	2.1e-22	1.9e-18
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0553	0.0279	1.9e-03	0.008	0.005	0.017	NA	0.022	3.6e-02	8.5e-02	4.6e-03	NA	1.4e-03
7	TCGA	Pheochromocytoma and Paraganglioma	0.1720	0.0890	2.5e-03	0.050	0.027	0.020	NA	0.039	4.9e-03	3.0e-02	5.1e-02	NA	1.1e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Handedness (chirality/laterality): Left-handed	2.9	3.5	8.3	0.2	-0.7	-0.9	2.4	2.6	-1.5	-2.9
Tinnitus: Yes, but not now, but have in the past	2.6	2.8	6.4	1.1	-0.1	2.2	2.5	1.8	0.4	-1.9
Prostate Cancer	2.2	3.1	8.1	-1.5	-0.7	2.0	-1.3	0.6	2.9	2.3
Ever highly irritable/argumentative for 2 days	2.2	2.6	8.1	-1.2	0.0	-0.8	-1.7	-2.8	1.6	1.6
Blood White Count	2.1	15.4	60.2	0.5	-2.2	-3.2	-7.8	-0.3	1.2	5.5
Hayfever, allergic rhinitis or eczema	2.1	4.6	15.8	0.3	0.5	0.8	4.0	1.6	-1.4	-3.3
Primary Biliary Cirrhosis	2.0	2.9	7.2	0.4	-0.6	-0.9	1.5	2.2	-2.7	-2.2
Average weekly spirits intake	2.0	2.4	7.3	-1.3	2.7	-2.0	0.1	-1.7	-1.0	-0.2
Illnesses of father: None of the above (group 1)	2.0	2.5	7.8	0.7	-2.7	-0.8	-0.5	2.8	-1.0	-0.7
Breast Cancer	1.9	4.5	9.1	-0.7	1.9	0.2	-3.0	-2.1	2.2	3.0
Length of working week for main job	1.9	2.1	4.8	1.7	1.3	-2.2	0.3	1.0	-1.8	-1.1
Severe depression (siblings)	1.7	1.9	5.9	0.8	-0.7	1.1	2.4	1.0	-0.5	-2.1
Bilateral oophorectomy (both ovaries removed)	1.7	2.0	7.5	-0.5	-2.7	1.5	-0.4	-1.4	1.1	0.8
Lung cancer (father)	1.7	2.0	6.6	-1.5	-0.6	-1.1	-2.6	-1.4	0.8	1.2
Pulse wave peak to peak time	1.7	2.0	6.6	0.7	-0.4	1.6	2.6	0.1	0.3	-2.1
Medication: Allopurinol	1.7	2.3	4.3	-1.8	-1.2	0.3	-2.1	0.8	1.5	2.1
Commuting to job workplace: Public transport	1.7	2.0	4.5	-0.3	-2.1	-0.7	1.5	1.3	-1.1	-2.0
Mean Putamen Volume	1.6	1.8	3.7	0.5	1.8	0.9	-1.5	-0.6	1.9	1.6
Allergy or Eczema	1.6	4.1	13.2	0.1	0.7	0.5	3.6	2.1	-1.3	-3.0
Migraine (self-reported)	1.6	2.0	3.6	1.5	-0.1	-1.9	0.8	1.8	-1.7	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.2	8.9	3.0	0.4	-1.4	1.7	0.8	-1.8	-2.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	4.2	-0.8	0.7	1.3	-0.7	-2.0	1.8	1.6
Schizophrenia vs Biploar Disorder	1.5	2.0	4.8	-0.9	-0.8	0.0	-2.2	-1.6	0.7	2.1
Average weekly fortified wine intake	1.5	1.8	5.5	1.1	0.6	2.3	0.4	1.8	1.0	1.0
Mouth/teeth dental problems: Loose teeth	1.5	1.7	4.0	-0.1	0.9	0.5	-2.0	-1.4	1.5	1.7
Noisy workplace	1.4	1.7	6.7	2.6	1.6	0.3	-0.7	-1.0	-0.1	0.9
Pain type(s) experienced in last month: Hip pain	1.4	1.8	4.6	-1.5	-0.6	0.5	-1.7	-0.6	1.3	2.1
Average weekly beer plus cider intake	1.4	2.1	4.7	-1.6	1.2	-1.9	0.2	1.5	-2.2	-0.2
Alcohol drinker status: Previous	1.4	1.6	5.2	0.5	-0.6	1.3	-1.0	-2.3	0.8	1.5
Coronary Artery Disease (CAD)	1.3	1.5	5.9	-0.5	2.4	0.0	-1.2	-1.4	-0.7	0.6
Allergy	1.3	2.9	10.4	-0.2	-0.0	-1.6	-3.2	-1.3	0.8	2.3
Emphysema/chronic bronchitis	1.3	1.4	3.8	-1.2	-0.2	0.3	1.9	0.9	-1.1	-1.6
Medication: Gliclazide	1.3	1.4	6.6	-0.6	-0.2	-0.2	-0.7	-2.6	0.4	1.5
Guilty feelings	1.3	2.0	8.7	0.7	1.6	-0.7	-0.8	-2.9	-0.6	0.8
Financial difficulties in last 2 years	1.2	1.6	2.9	1.1	1.5	0.5	-0.9	-1.4	1.7	1.4
Prospective memory result	1.2	1.4	2.8	-0.1	-1.4	0.5	-1.7	-1.4	0.2	1.7
Pulse wave Arterial Stiffness index	1.2	1.4	4.2	-0.5	0.3	-1.6	-2.0	0.3	-0.6	1.6
Pulse wave reflection index	1.2	1.5	5.0	-0.7	0.6	-1.2	-2.2	-0.3	-0.1	1.9
Gout (self-reported)	1.2	1.6	4.1	-0.6	-1.1	0.6	-1.8	0.8	1.2	2.0
Commuting to job workplace: Cycle	1.2	1.4	3.9	0.3	-0.8	0.2	-1.8	-0.3	1.4	2.0
Cholesterol lowering medication	1.2	1.7	10.8	0.2	0.1	-0.9	-0.3	-3.3	0.1	-0.4
Alzheimer’s Disease (in mother)	1.1	1.3	3.9	0.8	2.0	-1.4	-1.3	-0.4	-0.2	0.7
Alzheimer’s Disease (including proxy)	1.1	1.6	3.4	-0.4	1.8	-1.2	-1.8	-0.7	-0.0	1.4
Blood Eosinophil Count	1.1	8.2	28.5	-1.4	0.6	-4.0	1.4	1.2	-5.3	-2.8
Impedance of leg (left)	1.1	5.3	12.5	0.9	-0.8	-2.1	2.5	1.8	-3.1	-3.5
Medication: Simvastatin	1.1	1.6	8.4	0.4	0.5	-0.2	-0.6	-2.9	1.5	0.2
Depression (self-reported)	1.1	1.4	3.4	0.2	1.2	-1.9	0.4	-1.4	-1.3	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	4.6	-0.3	2.1	0.7	1.6	-0.9	0.1	-0.6
Neck or shoulder pain in last month	1.1	1.5	3.9	-0.4	-1.4	-0.6	-2.0	-0.8	0.5	1.8
Miserableness	1.1	1.9	4.5	1.0	1.5	-0.1	-1.6	-2.1	0.6	1.5
Wears glasses or contact lenses	1.1	1.3	6.8	-2.6	-0.0	0.1	-0.4	-0.0	0.7	1.2
Ever taken oral contraceptive pill	1.1	1.2	5.1	0.9	2.2	-1.2	0.2	-0.2	-0.9	-0.6
Alcohol drinker status: Never	1.1	1.3	2.4	-1.6	-1.4	1.2	-0.7	0.3	1.1	1.3
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	3.5	0.7	-0.0	-0.7	1.4	-0.2	-1.9	-1.7
Depressed Affect (Nagel 2018)	1.0	2.0	5.1	1.1	1.0	-0.1	-1.8	-1.6	1.1	2.3
Type 2 Diabetes (T2D) (2012)	1.0	1.2	5.0	-0.7	-1.1	0.0	-2.2	0.3	0.5	1.2
Hand grip strength (left)	1.0	2.7	9.4	0.9	-0.2	-0.3	2.7	-0.0	-1.4	-3.1
Impedance of leg (right)	1.0	4.7	11.9	0.9	-0.7	-1.5	2.5	1.7	-2.9	-3.4
Qualifications: None of the above	1.0	2.1	4.7	0.9	0.1	-2.2	-2.0	-1.9	-0.7	0.8
Pain all over the body in last month	1.0	1.1	3.0	1.7	0.6	0.2	-1.4	0.6	0.9	1.1
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.8	1.4	-0.5	0.7	1.6	0.8	-0.2	-1.7
Mouth/teeth dental problems: Dentures	1.0	1.7	5.3	0.4	-0.0	0.0	-2.0	-0.3	2.3	1.6
Medication: Paracetamol	1.0	1.7	3.6	0.9	1.9	1.0	-1.1	-1.0	1.2	1.7
Family relationship satisfaction	1.0	1.2	2.4	-0.1	-1.1	-1.2	1.6	1.3	-0.9	-0.9
Eye problems/disorders: Cataract	1.0	1.2	3.0	1.7	0.3	0.4	-1.3	0.3	1.5	1.1
Financial situation satisfaction	1.0	1.2	2.5	-0.0	0.4	0.8	-0.9	-1.6	1.6	1.4
Diastolic blood pressure, automated reading	1.0	3.0	5.4	-2.3	-2.1	-1.9	-1.0	-1.4	-1.9	1.2
Reaction Time	0.9	1.7	5.8	-0.3	2.4	0.0	-1.1	-1.6	1.0	1.0
Schizophrenia (2014)	0.9	2.0	4.4	-0.4	-0.6	2.1	-1.0	-1.9	1.6	1.4
Hypothyroidism (self reported)	0.9	2.0	3.5	0.9	-0.2	1.5	-1.6	-1.2	1.9	1.8
Medication for hormone replacement therapy	0.9	1.0	2.7	-0.2	-0.5	0.9	1.7	0.8	-0.2	-1.6
Qualifications: CSEs or equivalent	0.9	1.2	3.5	0.6	0.9	-0.9	-1.1	-1.9	0.2	1.3
Medication: Atenolol	0.9	1.2	2.7	-0.4	-1.6	-1.6	0.6	-1.1	0.4	-1.1
Mouth/teeth dental problems	0.9	1.3	3.1	-0.0	-0.9	0.3	1.7	0.5	-1.8	-1.5
Heart attack	0.9	1.1	2.7	0.9	0.5	-1.6	0.8	-0.5	-1.1	-1.3
Impedance of arm (right)	0.9	4.1	12.5	0.7	-1.4	-1.8	0.4	3.5	-2.3	-2.3
Father’s age at death	0.9	1.1	4.0	-1.3	-0.3	2.0	1.1	-0.2	-0.0	-0.9
Number of live births	0.9	1.3	2.7	0.0	-1.6	1.0	-1.1	0.3	1.5	1.3
Pulse rate	0.9	1.5	5.3	-1.3	0.6	0.7	-1.5	-0.5	0.2	2.3
Wheeze or whistling in the chest in last year	0.9	1.7	4.2	-0.4	-0.9	1.8	-0.9	-1.3	2.0	0.9
Medication: Blood pressure	0.9	1.5	3.3	-1.1	-1.4	-1.1	-1.5	-1.8	-0.2	0.9
Osteoporosis (self-reported)	0.9	1.1	4.1	0.7	-1.1	-0.4	1.1	0.0	-2.0	-0.5
Medication: Aspirin	0.9	1.2	2.0	0.1	-1.2	-1.4	1.0	-1.2	-0.9	-1.4
Ever had prostate specific antigen (PSA) test	0.9	1.1	2.0	-1.4	0.2	-0.8	0.9	1.2	-1.4	-0.8
Bipolar Disorder (2018)	0.8	1.2	2.8	-0.9	-1.7	0.0	0.3	1.0	-1.3	-1.4
Neuroticism (Nagel 2018)	0.8	1.9	4.1	0.9	0.6	0.2	-1.3	-2.0	1.4	2.0
Verbal and Numeric Reasoning (VNR)	0.8	2.0	5.2	-0.8	0.5	0.7	1.7	2.3	-1.2	-1.6
Number of treatments/medications taken	0.8	1.5	5.4	-0.2	-0.3	-0.8	-1.5	-2.3	0.5	1.3
Sensitivity / hurt feelings	0.8	1.4	3.7	1.6	0.6	-1.3	-1.1	-1.9	0.5	0.5
Frequency of depressed mood in last 2 weeks	0.8	1.1	3.3	1.7	1.0	1.8	-0.0	-0.2	0.5	-0.0
Diabetes (mother)	0.8	1.0	1.9	-1.0	-1.4	0.2	-1.2	-0.9	0.9	0.9
Current tobacco smoking	0.8	1.4	3.8	0.5	0.9	-1.0	-1.9	-0.6	0.6	1.8
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	3.8	1.4	0.5	1.9	0.5	-1.0	1.2	0.6
Had menopause	0.8	1.0	3.1	0.7	-1.2	1.8	-0.6	0.1	1.2	0.4
Impedance of arm (left)	0.8	3.7	9.0	0.5	-2.0	-1.6	0.5	3.0	-2.1	-2.2
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	3.0	1.3	-0.5	0.5	-1.7	-0.7	1.6	1.4
Number of full brothers	0.8	1.0	2.1	-0.7	-1.3	0.9	1.2	-0.4	-0.4	-1.4
Age at first live birth	0.8	1.4	2.9	-0.7	1.4	-1.5	0.4	0.2	-1.7	-1.2
Alcohol intake frequency.	0.8	2.0	4.5	-1.5	-1.5	0.1	-2.1	-1.1	0.3	1.9
Mood swings	0.8	1.4	2.1	1.4	1.5	-1.4	-0.5	-0.9	-1.5	0.6
Friendships satisfaction	0.8	0.9	2.2	-0.5	-1.1	-1.1	1.1	1.5	-0.4	-0.3
Commuting to job workplace: Walk	0.8	0.9	2.6	-0.9	-1.0	-1.6	-0.5	0.6	-1.1	-0.3
Osteoarthritis (self-reported)	0.8	1.0	2.9	0.8	0.4	-1.1	-1.7	-0.9	-0.5	1.1
Medication: Blood pressure	0.8	1.5	5.0	0.6	-0.9	-1.4	-1.4	-2.2	0.3	-0.1
Medication: Paracetamol	0.8	1.2	3.4	0.3	1.5	0.4	-1.4	-0.5	0.8	1.8
Fractured/broken bones in last 5 years	0.8	1.1	2.6	0.3	-1.6	1.1	1.6	-0.7	-0.6	-0.7
Age started oral contraceptive pill	0.8	1.0	4.0	-2.0	0.4	0.6	-0.8	-0.4	0.8	1.0
Ever depressed for a whole week	0.8	1.0	3.6	-1.9	-0.4	-1.4	-0.5	-1.0	-0.5	0.5
Impedance of whole body	0.8	4.3	7.8	0.4	-1.7	-1.9	1.2	2.6	-2.7	-2.8
Ulcerative Colitis (UC)	0.7	1.2	3.3	-0.2	-1.5	1.8	1.3	-0.3	-0.0	-1.0
Neuroticism (2016)	0.7	1.0	2.7	1.1	-0.4	-1.6	0.5	0.2	-1.0	-1.3
Triglycerides	0.7	1.2	3.2	-1.4	-0.2	-1.4	0.4	-0.5	-1.8	-0.8
Systolic blood pressure, automated reading	0.7	2.2	4.6	-2.0	-2.1	-1.5	-0.6	-1.5	-0.8	0.9
Relative age voice broke	0.7	1.0	2.9	0.3	-0.6	-1.7	0.5	1.1	-1.1	-1.1
Chronic bronchitis/emphysema (father)	0.7	0.8	2.0	1.1	0.0	0.5	1.4	-0.9	-0.7	-1.0
Past tobacco smoking	0.7	1.2	2.1	-1.5	-0.9	0.2	-0.6	1.3	1.3	1.2
Hair/balding pattern: Pattern 2	0.7	0.9	2.8	1.3	-0.6	1.7	0.7	-0.9	0.6	0.0
Medication: Amlodipine	0.7	0.9	4.0	0.6	-2.0	0.2	-1.1	0.5	0.8	0.2
Exposure to tobacco smoke outside home	0.7	0.9	2.2	0.5	1.5	0.8	-0.2	-0.4	0.9	1.4
Medication: Omeprazole	0.7	0.8	2.5	0.2	-0.3	-0.3	1.2	-0.1	-1.6	-1.4
Medication for cholesterol	0.7	1.0	4.1	-1.3	0.6	0.3	0.2	2.0	-0.6	0.7
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.8	1.0	0.0	0.6	-1.1	-0.3	0.7	1.7
Blood Platelet Count	0.6	7.3	16.4	1.2	-1.9	2.0	3.8	4.0	-1.4	-3.1
Cardiovascular Disease	0.6	2.1	6.7	0.7	-0.1	-2.6	-1.5	-2.3	-0.4	-0.0
Respiratory disease	0.6	1.4	3.7	-1.1	0.2	1.5	1.9	1.3	-0.6	-0.9
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.6	0.0	0.0	-0.8	-1.6	-1.3	0.8	1.2
Ever had hysterectomy (womb removed)	0.6	0.7	2.7	0.1	-1.7	1.4	0.2	-0.5	0.1	-0.0
Pack years adult smoking proportion	0.6	0.9	3.8	-0.3	-1.1	1.9	1.1	-0.1	-0.0	0.0
Fed-up feelings	0.6	1.1	2.1	1.4	1.3	-0.1	-1.5	0.2	0.3	1.3
Serious illness, injury or assault to yourself	0.6	0.7	2.0	0.9	0.4	1.4	0.1	-1.2	-0.7	0.3
High blood pressure	0.6	1.6	4.4	-0.4	-1.2	-1.7	-1.3	-2.1	-0.6	0.0
Stomach or abdominal pain in last month	0.6	0.7	1.9	1.3	0.3	0.3	1.0	-0.1	-0.1	-1.4
Number of incorrect matches in round	0.6	1.0	2.8	-0.9	0.8	1.7	0.3	-1.4	-0.0	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	3.7	-0.9	-0.8	-0.1	-1.7	-1.0	0.9	1.9
Diabetes (self-reported)	0.6	0.9	4.2	-0.5	-0.3	-1.1	-0.1	-2.0	-0.5	-0.3
Fluid intelligence score	0.6	1.3	6.2	-0.7	0.6	-0.3	0.6	2.5	-0.9	-0.9
Hair/balding pattern: Pattern 3	0.6	0.9	2.0	-1.1	0.2	-0.7	-1.4	1.0	-0.1	1.4
Asthma	0.6	1.3	5.8	-0.2	-0.6	2.4	1.3	0.8	0.5	-0.3
Illnesses of mother	0.6	0.7	2.3	1.4	0.5	-1.5	0.0	-0.1	-0.7	-0.6
Breastfed as a baby	0.6	0.8	3.1	-0.0	-0.4	1.8	1.0	0.7	0.4	-0.6
Loud music exposure frequency	0.6	0.7	2.9	-0.8	-0.2	0.1	-0.8	-1.7	0.8	0.3
Blood clot in the leg (DVT)	0.6	0.7	2.1	1.1	0.2	0.6	-0.9	-0.2	0.6	1.4
Medication: Ventolin 100micrograms inhaler	0.6	0.8	3.6	-0.9	-1.9	0.4	-0.0	1.0	-0.2	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	2.8	1.7	0.6	0.8	-0.7	-0.5	0.4	0.7
Number of children fathered	0.6	0.7	1.7	1.0	0.1	-0.1	1.3	0.8	0.6	-1.1
Shortness of breath walking on level ground	0.6	0.7	1.4	-0.4	-1.2	-0.8	0.4	-0.4	-1.2	-1.1
Eye problems/disorders: None of the above	0.6	0.6	1.8	-1.3	1.2	0.1	-0.6	-0.5	0.3	0.8
Medication for pain relief, constipation, heartburn	0.6	1.0	2.0	-0.9	-0.2	-1.2	0.5	1.4	-1.3	-0.8
Heart disease (mother)	0.6	0.8	2.8	-1.1	-1.7	-0.3	0.2	-0.4	-1.1	0.2
Pulse rate, automated reading	0.6	1.8	5.7	-0.8	-1.8	0.6	-1.7	0.1	0.3	2.4
Medication: Aspirin	0.6	0.7	2.7	0.2	-1.6	-0.7	0.6	-1.0	0.1	-0.8
Illnesses of siblings: Diabetes	0.6	0.7	2.1	-0.3	-0.6	-1.1	-1.1	1.5	0.2	-0.0
Average weekly red wine intake	0.6	0.9	1.6	0.1	-1.3	1.0	1.2	-1.2	0.8	-0.6
Loneliness, isolation	0.6	0.8	4.6	2.1	0.6	0.1	0.1	0.4	-0.8	0.4
Breast cancer (self-reported)	0.6	0.8	1.5	-0.7	-1.2	-0.7	1.0	-0.0	-1.2	-0.7
Unable to work because of sickness or disability	0.6	0.7	1.8	1.0	-0.7	0.2	-0.8	1.1	-0.1	1.3
Vascular/heart problems diagnosed by doctor	0.6	1.7	5.7	-0.1	1.4	1.7	0.8	2.4	0.5	0.5
Pack years of smoking	0.6	0.9	4.5	-0.6	-1.0	2.1	0.7	-0.1	0.3	0.4
Intelligence (Savage-Jansen 2018)	0.5	1.6	6.9	-0.5	-0.1	1.8	0.7	2.6	-0.3	-0.4
Irritable Bowel Disease (IBD)	0.5	1.2	3.2	-0.3	-1.6	1.8	0.8	-0.9	0.7	-0.8
Fasting Glucose	0.5	0.6	1.6	-0.5	0.6	-0.4	1.1	0.3	-0.5	-1.3
HbA1C	0.5	0.6	1.1	0.9	0.4	0.5	0.9	1.1	0.4	-0.8
LDL Cholesterol	0.5	0.7	2.8	-1.7	-0.4	-0.3	0.9	0.2	-0.5	-0.9
Heel T-Score	0.5	3.7	11.3	-0.2	0.2	-0.3	-3.4	-2.8	1.6	2.1
Systolic Blood Pressure	0.5	2.4	6.7	0.1	-1.5	-2.6	-1.0	-2.3	-1.1	0.5
Smoking Status	0.5	1.2	2.3	1.2	1.1	-0.5	-1.5	-1.2	-0.2	1.3
Angina	0.5	0.7	2.0	1.4	0.0	-0.4	1.1	-1.0	0.2	-0.7
Supplements: Zinc	0.5	0.5	1.0	0.6	-1.0	0.4	0.6	1.0	-0.5	-0.7
Hand grip strength (right)	0.5	1.4	4.3	0.6	-0.6	0.6	2.0	-0.1	-0.7	-2.1
Maternal smoking around birth	0.5	0.7	1.6	0.2	-0.1	-0.1	0.9	1.2	-1.3	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	2.6	-1.3	-0.9	-0.4	-1.4	-0.8	0.6	1.6
High blood pressure (mother)	0.5	0.8	2.8	-1.7	-0.6	0.5	-0.2	-1.1	0.5	0.6
Body mass index (BMI)	0.5	2.0	5.7	-0.5	-0.1	1.2	-1.0	-2.1	1.0	2.4
Alcohol usually taken with meals	0.5	0.8	2.7	-0.8	-0.5	0.8	-0.5	0.4	1.6	1.1
Medication: Ramipril	0.5	0.6	1.9	-0.8	-0.6	-1.4	-0.8	-0.3	-0.8	0.3
Falls in the last year	0.5	0.6	2.2	1.5	-0.2	-0.3	0.4	1.2	-0.8	-0.1
Happiness	0.5	0.6	2.4	-0.2	-0.9	-0.5	0.5	1.6	-0.4	0.3
Qualifications: A levels/AS levels or equivalent	0.5	1.2	4.1	-0.2	0.6	0.9	2.0	0.4	0.1	-1.6
Tense / ‘highly strung’	0.5	0.8	1.5	-0.7	-1.2	-0.1	1.1	1.1	-0.9	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	3.3	0.6	0.3	-1.8	0.1	-0.6	-1.1	-0.3
Birth weight of first child	0.5	0.9	2.3	-1.0	-1.5	0.1	-0.8	0.7	1.0	0.7
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	1.7	-0.6	0.0	1.2	0.9	1.3	0.9	-0.4
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	2.5	-0.5	0.6	0.2	-0.4	-1.6	0.5	0.8
Glaucoma (self-reported)	0.5	0.6	2.1	-0.7	-0.7	0.1	1.4	0.1	-0.8	-0.6
Birth weight	0.5	1.0	3.1	-1.0	0.9	1.2	0.7	-1.8	0.4	0.1
High blood pressure (siblings)	0.5	0.7	1.2	0.7	0.1	-1.0	0.8	0.5	-1.0	-1.1
Health satisfaction	0.5	0.6	2.3	1.2	0.1	0.5	-0.5	-0.0	-0.0	1.5
Mean time to correctly identify matches	0.5	0.9	2.3	-1.0	1.5	-0.2	-0.8	-1.5	0.2	0.6
Number of full sisters	0.5	0.6	1.4	0.0	0.7	-0.9	-0.8	-1.2	-1.0	0.2
Had major operations	0.5	0.6	2.4	-0.1	0.5	-1.6	0.4	0.4	-0.6	-0.7
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.7	0.5	1.3	-0.3	0.1	-1.3	0.4	-0.0
Supplements: Vitamin C	0.5	0.6	1.6	1.3	-0.0	0.9	-0.5	-0.9	0.3	0.8
Knee pain experienced in last month	0.5	0.8	2.1	-0.1	0.5	-1.3	-1.4	-0.7	0.1	1.1
Hypertension (Self-reported)	0.5	1.4	3.2	-0.5	-1.1	-1.8	-1.3	-1.5	-0.9	0.0
Smoking status: Previous	0.5	0.8	1.9	0.6	1.4	-0.3	0.3	-1.1	-1.0	-0.8
Ever had bowel cancer screening	0.5	0.6	2.8	0.9	-0.2	1.7	0.3	-0.1	0.3	0.4
Mineral and other dietary supplements	0.5	0.7	3.4	1.8	1.1	-0.2	-0.5	0.3	-0.1	-0.0
Asthma (self-reported)	0.5	1.1	3.5	-0.1	-0.6	1.9	1.5	0.9	0.2	-0.8
Smoking status: Current	0.5	0.8	1.8	0.6	0.8	-0.8	-1.4	-0.6	0.2	1.2
Number of self-reported non-cancer illnesses	0.5	0.9	3.7	-0.1	-0.8	-1.9	-0.1	-0.6	-1.1	-0.4
Average weekly champagne plus white wine intake	0.5	0.7	2.2	-0.0	-0.5	1.1	1.5	-0.1	0.5	-1.1
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.3	0.4	0.1	-1.2	0.5	0.1	-1.1	-1.0
Eye problems/disorders: Glaucoma	0.5	0.6	1.4	0.6	-1.1	0.6	1.2	0.4	-0.4	-0.8
Ever smoked	0.5	1.0	2.5	1.5	0.8	-0.6	0.1	-1.6	-0.7	-0.7
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.9	0.7	0.3	-1.4	0.5	-0.6	-0.6	-1.0
Heart disease (siblings)	0.5	0.6	1.7	0.1	-0.5	-0.1	-1.2	-0.2	0.8	1.3
Crohns Disease (2017)	0.4	0.9	2.1	-0.3	-0.8	1.2	0.3	-1.5	1.0	-0.8
Body Mass Index (BMI) (2010)	0.4	0.6	2.6	0.0	-1.6	1.1	0.3	0.4	0.4	-0.1
Ulcerative Colitis	0.4	0.6	2.8	-0.7	-0.5	0.0	-0.2	-1.7	0.4	0.4
Lung FEV1/FVC ratio	0.4	1.9	4.8	2.0	0.3	-0.7	-2.2	0.1	0.8	1.8
Neuroticism	0.4	1.0	1.8	0.8	0.8	-0.3	-1.3	-1.1	0.7	1.3
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.7	0.1	-0.6	1.3	-0.1	-0.6	0.3	0.9
Taking other prescription medications	0.4	0.6	1.2	-0.8	-0.1	-1.0	-0.8	-0.9	0.3	1.1
Waist circumference	0.4	1.6	3.4	-0.8	-0.9	1.8	-0.5	-1.6	0.9	1.8
Hearing difficulty/problems with background noise	0.4	0.7	2.8	0.3	0.0	1.7	-0.0	-0.6	1.0	0.8
Had other major operations	0.4	0.5	2.2	0.3	0.0	0.8	-0.0	-1.5	0.7	0.1
Illnesses of siblings	0.4	0.6	3.1	-0.5	0.2	1.7	1.0	-0.3	0.0	0.0
Neuroticism score	0.4	0.9	1.9	1.3	1.4	-0.3	-0.5	-1.2	-0.5	0.9
Alcohol intake versus 10 years previously	0.4	0.7	1.5	-1.1	1.1	0.3	0.5	-0.6	-1.2	-0.2
Worrier / anxious feelings	0.4	0.8	2.7	0.3	-0.5	0.3	-0.9	-1.6	0.2	1.4
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.6	-0.6	-0.6	-0.2	0.8	0.2	-1.3	-0.6
Medication: Lansoprazole	0.4	0.5	1.1	0.9	0.4	-1.0	-0.9	0.1	-0.3	0.7
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.2	0.7	0.5	0.7	0.8	1.5	-0.5	-0.6
Arm fat-free mass (right)	0.4	1.8	5.9	-0.6	0.3	1.9	0.4	-2.4	1.2	1.1
Worry too long after embarrassment	0.4	0.7	1.5	1.1	1.2	0.4	0.6	-1.2	0.6	-0.4
Angina (self-reported)	0.4	0.6	1.4	1.0	0.0	-0.5	1.2	-0.8	-0.0	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.3	0.9	0.3	0.0	-0.9	-0.1	0.6	1.1
Arm predicted mass (right)	0.4	2.0	6.1	-0.4	0.5	2.0	0.4	-2.5	1.3	1.2
Overall health rating	0.4	0.9	3.2	1.8	0.6	1.3	0.1	-0.5	0.7	0.8
Chest pain or discomfort	0.4	0.6	2.5	-0.3	-0.6	0.9	0.3	-1.6	0.6	-0.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.2	-0.6	0.5	-0.9	-1.1	0.1	0.4	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.3	-0.5	-1.0	0.3	-0.1	-1.2	0.7	-0.2
Qualifications: nursing, teaching	0.4	0.6	3.7	-0.2	0.1	-0.2	0.5	1.9	-0.6	-0.3
Back pain experienced in last month	0.4	0.6	1.8	-1.3	-0.7	0.2	-0.7	-0.2	0.8	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.5	0.7	1.2	-1.6	-0.6	0.1	-0.8	0.1
Supplements: Fish oil (including cod liver oil)	0.4	0.6	2.4	-0.4	0.1	0.7	1.6	-0.4	0.4	-0.8
Medication: Atorvastatin	0.4	0.5	1.4	0.9	-1.2	-0.3	0.7	-0.1	-0.6	-0.8
Illnesses of father: High blood pressure	0.4	0.5	1.3	-0.6	0.6	1.1	0.6	-1.0	0.3	-0.5
Pain experienced in last month	0.4	0.6	1.2	-0.0	0.7	-0.1	1.1	-0.4	-1.1	-1.1
Supplements: Calcium	0.4	0.5	1.2	-0.6	-1.1	-1.0	-0.4	0.0	-0.2	-0.7
Basal cell carcinoma (self-reported)	0.4	0.5	1.7	0.1	0.4	-0.5	0.6	-0.8	-0.5	-1.3
Worry (Nagel 2018)	0.3	0.7	3.2	-0.4	-0.5	0.6	-0.4	-0.3	0.8	1.8
Alzheimer’s Disease (in father)	0.3	0.4	1.0	-0.8	1.0	-0.0	0.6	-0.5	-0.5	-0.5
Major Depression (MDD)	0.3	0.4	1.4	1.2	-0.8	0.0	0.1	0.5	0.4	0.0
Age at First Birth	0.3	0.4	1.4	1.2	-0.9	0.5	0.6	0.0	0.0	-0.4
HDL Cholesterol	0.3	0.4	1.4	-0.5	-0.4	-0.2	-0.8	0.3	0.7	1.2
Lupus	0.3	0.4	1.1	0.6	-0.8	-0.1	0.3	-1.1	-0.5	-0.4
Chronotype (morning person)	0.3	0.6	2.0	0.6	-0.1	0.5	0.4	-1.4	1.2	0.5
Hearing difficulty/problems: Yes	0.3	0.4	1.2	-0.9	-0.5	-1.1	-0.1	0.7	-0.5	0.1
Relative age of first facial hair	0.3	0.6	1.7	0.3	-0.4	-1.1	0.3	0.5	-1.3	-0.4
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.2	-0.2	-0.2	-0.5	0.1	-0.8	-0.1	-1.1
Medication: Co-codamol	0.3	0.4	1.7	-0.3	-1.3	0.4	-0.3	-0.1	0.1	0.6
Diabetes (father)	0.3	0.4	1.0	0.3	0.4	0.1	-0.6	-0.4	0.9	1.0
Leg fat-free mass (left)	0.3	1.4	3.2	-0.8	-0.0	1.8	-0.2	-1.7	1.2	1.4
Trunk fat percentage	0.3	1.1	3.4	-1.3	-1.8	-0.1	-0.5	-1.2	-0.5	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.3	1.2	-0.2	0.4	-0.6	-0.4	-0.4	0.7
Multivitamins +/- minerals	0.3	0.4	0.9	0.0	-0.2	-0.6	0.9	0.3	-0.5	-1.0
Supplements: Glucosamine	0.3	0.4	1.2	-0.2	-0.4	-0.2	0.9	1.1	-0.7	-0.5
Medication: Levothyroxine sodium	0.3	0.5	1.9	0.7	-0.3	-0.1	-1.4	-0.7	0.5	0.5
Leg predicted mass (left)	0.3	1.4	3.2	-0.8	0.0	1.8	-0.2	-1.7	1.2	1.3
Nervous feelings	0.3	0.6	1.6	1.3	-0.4	-0.5	-0.6	0.7	-0.2	1.2
Hip circumference	0.3	1.1	4.1	-0.9	0.2	2.0	0.1	-1.0	0.8	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	2.4	1.5	0.3	0.7	0.1	-0.2	0.8	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	1.0	0.2	0.2	1.0	0.1	0.4	1.0	0.3
Arm fat mass (right)	0.3	1.1	2.9	-0.5	-0.6	1.1	-0.8	-1.5	0.6	1.7
Standing height	0.3	2.7	6.8	0.6	-0.4	0.1	2.6	1.4	-1.9	-2.5
Hair/balding pattern: Pattern 4	0.3	0.6	2.0	-0.5	-0.4	-0.5	-0.7	-1.4	1.1	0.3
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.9	0.9	-0.3	0.4	0.8	0.8	-0.1	-0.6
Comparative body size at age 10	0.3	1.0	3.2	1.4	1.8	0.6	-0.3	-0.2	-0.4	0.9
Medication: Ibuprofen	0.3	0.4	1.5	-0.0	-0.3	0.6	-0.6	0.3	1.2	0.7
Leg fat mass (right)	0.3	1.2	3.8	-0.5	-0.7	1.2	-0.2	-1.9	0.4	1.5
Age at last live birth	0.3	0.4	1.0	-0.8	0.4	-0.1	0.5	1.0	-0.2	-1.0
Leg pain on walking	0.3	0.4	2.3	1.5	0.1	0.4	0.6	-0.1	-0.1	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.0	0.4	-1.0	0.2	-0.9	-0.4	0.4	0.6
Illnesses of father: Heart disease	0.3	0.4	0.9	0.6	0.6	-0.2	-0.9	-0.9	0.6	0.5
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.9	-0.4	1.4	-0.9	-0.6	0.3	-0.5	0.2
Arm fat mass (left)	0.3	1.2	3.0	-0.2	-0.8	1.2	-0.6	-1.5	0.8	1.7
High cholesterol (Self-reported)	0.3	0.5	1.5	-0.2	-0.9	-1.0	-0.2	-1.2	0.1	-0.5
Medication: Bendroflumethiazide	0.3	0.5	1.7	0.5	-0.2	0.5	-1.0	0.2	1.3	0.1
Medication: Lisinopril	0.3	0.3	1.2	-0.3	-0.8	-0.4	-0.3	-1.1	-0.4	0.3
Arm fat-free mass (left)	0.3	1.7	4.9	-0.2	0.5	2.0	0.4	-2.2	1.1	1.1
Number of operations (self-reported)	0.3	0.5	2.4	1.5	-0.0	0.5	0.4	-0.5	0.3	0.2
Risk taking	0.3	0.4	0.9	-1.0	0.7	0.8	-0.3	-0.5	0.5	0.3
Leg fat mass (left)	0.3	1.2	3.4	-0.6	-0.6	1.0	-0.4	-1.8	0.4	1.6
Arm predicted mass (left)	0.3	1.6	4.9	0.2	0.7	1.9	0.3	-2.2	1.1	1.1
Depression (Nagel 2018)	0.2	0.3	0.7	0.8	0.2	0.8	-0.4	0.3	-0.0	0.4
Schizophrenia (2018)	0.2	0.4	1.6	0.5	0.0	0.8	-0.4	-1.3	0.3	0.5
Ovarian Cancer	0.2	0.2	0.6	-0.7	0.5	0.0	-0.4	-0.7	-0.3	-0.1
Crohns Disease (2012)	0.2	0.3	1.6	0.1	0.5	0.0	0.0	-1.3	0.0	-0.6
Rheumatoid Arthritis	0.2	0.2	0.7	-0.8	0.3	-0.3	-0.6	0.0	0.1	0.5
BMI	0.2	1.3	3.0	-1.2	-0.5	1.1	-0.5	-1.7	0.5	1.6
Waist Hip Ratio (WHR)	0.2	0.7	4.2	0.0	-2.0	-0.6	-0.1	-0.3	-0.7	0.3
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.8	0.5	0.1	0.9	-0.3	-0.9	0.3	-0.2
Medication: Metformin	0.2	0.3	1.0	0.3	0.5	-0.5	0.3	-1.0	-0.4	-0.4
Townsend deprivation index at recruitment	0.2	0.3	1.9	-0.1	-0.6	-0.2	-1.4	0.1	0.0	0.4
Age when periods started (menarche)	0.2	0.4	2.2	-0.2	-0.5	0.1	-0.4	1.5	0.2	-0.4
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.7	-0.8	-0.4	0.0	-0.2	0.8	-0.6	0.5
Trunk fat mass	0.2	0.9	2.2	-1.1	-1.5	0.4	-0.2	-1.3	-0.3	0.9
Forced vital capacity (FVC)	0.2	0.8	4.2	0.7	2.0	0.0	0.6	0.2	-0.1	-0.8
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.7	-0.6	0.8	-0.8	-0.1	0.1	-0.0	0.3
Weight	0.2	0.8	1.9	-0.4	-0.3	1.4	0.2	-1.4	0.2	1.1
Arm fat percentage (right)	0.2	0.6	1.8	-0.3	-0.8	0.5	-0.8	-0.9	-0.0	1.4
Time employed in main current job	0.2	0.2	0.7	-0.4	0.9	-0.2	-0.1	-0.2	0.2	0.7
Exposure to tobacco smoke at home	0.2	0.3	0.6	-0.3	0.7	-0.4	0.3	-0.0	-0.7	-0.8
Forced vital capacity (FVC), Best measure	0.2	0.8	1.8	0.8	1.4	-0.1	0.9	0.4	-0.7	-1.2
Body fat percentage	0.2	0.7	1.8	-0.9	-1.3	0.2	-0.3	-1.2	-0.3	0.9
Leg fat percentage (right)	0.2	0.6	1.6	0.1	-0.8	0.9	0.2	-1.3	-0.2	0.9
Medication: Seretide 50 evohaler	0.2	0.2	0.8	0.1	-0.2	0.8	0.6	-0.9	-0.1	-0.1
Whole body fat mass	0.2	0.8	2.1	-0.8	-1.2	0.7	-0.2	-1.4	-0.0	1.0
Comparative height size at age 10	0.2	1.1	2.5	0.1	0.1	-0.2	1.5	1.4	-1.0	-1.6
Whole body fat-free mass	0.2	1.1	3.0	-0.1	0.6	1.7	0.5	-1.6	0.8	0.8
Leg fat-free mass (right)	0.2	1.1	2.4	-0.6	0.1	1.6	-0.3	-1.4	1.2	1.4
Arm fat percentage (left)	0.2	1.0	2.8	-0.4	-1.1	0.6	-1.0	-1.1	0.4	1.7
Diabetes diagnosed by doctor	0.2	0.4	0.8	-0.0	-0.3	-0.8	0.5	-0.9	-0.6	-0.7
Whole body water mass	0.2	1.1	2.8	-0.0	0.6	1.6	0.3	-1.7	0.9	0.9
Leg predicted mass (right)	0.2	1.2	2.5	-0.7	0.1	1.6	-0.3	-1.4	1.2	1.4
Hearing aid user	0.2	0.2	0.6	-0.0	0.4	-0.0	0.5	-0.7	-0.8	-0.2
Basal metabolic rate	0.2	1.0	2.9	-0.1	0.4	1.7	0.4	-1.7	0.7	0.9
Irritability	0.2	0.3	0.6	-0.2	0.8	-0.6	-0.7	-0.5	-0.0	0.6
Myopia	0.2	0.2	1.0	0.2	0.4	-0.1	-0.4	-0.1	0.6	1.0
Bipolar Disorder or Schizophrenia	0.1	0.2	0.9	-0.1	-0.9	0.3	-0.1	-0.4	-0.6	-0.5
Blood Red Count	0.1	1.2	3.8	-0.2	-0.9	1.0	1.9	-1.3	-0.2	-0.8
Height	0.1	1.7	3.6	0.6	0.2	0.5	1.9	1.7	-0.9	-1.9
Lung FVC	0.1	0.6	2.2	-0.5	1.5	0.5	-0.2	-0.1	1.1	0.2
Hair Pigment	0.1	1.7	5.4	0.9	1.5	-0.5	1.1	0.3	-2.3	-1.2
Tanning	0.1	0.7	4.3	-0.2	-0.3	2.1	0.4	-0.0	0.6	0.5
Vitamin and mineral supplements	0.1	0.2	0.5	-0.3	0.4	0.0	-0.7	-0.4	0.4	0.6
Sitting height	0.1	0.4	1.5	-0.5	-0.0	0.7	1.2	0.0	-0.3	-0.6
Trunk fat-free mass	0.1	0.8	2.4	0.5	0.8	1.6	1.0	-1.2	0.3	0.2
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.8	0.5	1.4	0.5	0.0	0.2	0.6	-0.1
Medication: Cholesterol lowering	0.1	0.1	0.3	-0.2	-0.4	-0.2	0.1	-0.6	0.5	-0.2
Trunk predicted mass	0.1	0.8	2.5	0.6	0.8	1.6	0.9	-1.2	0.4	0.4
Peak expiratory flow (PEF)	0.1	0.3	1.2	0.2	1.1	0.4	0.6	0.4	0.0	-0.2
Headache pain in last month	0.1	0.2	0.7	-0.1	-0.8	0.3	-0.6	0.2	0.2	0.2
Qualifications: College or University degree	0.1	0.5	1.5	-0.5	-0.4	0.0	0.8	0.6	-0.4	-1.2
Suffer from ‘nerves’	0.1	0.2	0.4	0.4	0.3	0.3	0.6	-0.3	-0.3	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.4	-0.5	-0.6	-0.4	-0.1	-0.3	-0.2	0.5
Long-standing illness, disability or infirmity	0.1	0.2	0.8	-0.1	-0.5	0.2	0.1	-0.5	-0.3	0.9
Mother’s age at death	0.1	0.2	0.5	-0.4	0.2	0.1	0.4	0.7	-0.2	-0.5
Leg fat percentage (left)	0.1	0.5	1.5	-0.1	-0.9	0.7	0.2	-1.2	-0.2	0.9
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.3	0.3	0.6	0.1	0.3	0.1	-0.2	-0.5

Hub : Genes

SLC9A3R1

Models

Trait associations