Best TWAS P=2.09e-10 · Best GWAS P=5.38e-11 conditioned to 0.000564
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | ADAM33 | 0.32 | 0.10 | lasso | 8 | 0.11 | 4.8e-09 | 5.9 | 5.9 | 4.0e-09 | -0.07 | 0.09 | 0.91 | FALSE |
| 2 | GTEx | Artery Tibial | UBOX5 | 0.18 | 0.07 | lasso | 4 | 0.05 | 5.4e-05 | 5.0 | -5.3 | 1.3e-07 | 0.03 | 0.01 | 0.98 | FALSE |
| 3 | GTEx | Cells EBV-transformed lymphocytes | UBOX5 | 0.35 | 0.22 | lasso | 4 | 0.23 | 5.7e-08 | -5.0 | -5.5 | 5.0e-08 | 0.02 | 0.01 | 0.98 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | UBOX5 | 0.13 | 0.12 | lasso | 5 | 0.12 | 3.7e-09 | -5.0 | -5.1 | 3.0e-07 | 0.04 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Colon Transverse | UBOX5 | 0.18 | 0.01 | lasso | 5 | 0.03 | 1.6e-02 | 4.1 | -6.3 | 2.9e-10 | 0.02 | 0.04 | 0.68 | TRUE |
| 6 | GTEx | Colon Transverse | FASTKD5 | 0.17 | 0.04 | enet | 31 | 0.10 | 1.8e-05 | -5.0 | 5.6 | 2.2e-08 | -0.03 | 0.01 | 0.90 | FALSE |
| 7 | GTEx | Heart Atrial Appendage | UBOX5 | 0.32 | 0.07 | enet | 14 | 0.13 | 1.5e-06 | -5.0 | -6.1 | 1.2e-09 | 0.03 | 0.01 | 0.98 | FALSE |
| 8 | GTEx | Heart Left Ventricle | UBOX5 | 0.20 | 0.09 | enet | 15 | 0.13 | 1.9e-07 | -4.2 | -5.5 | 4.8e-08 | 0.03 | 0.02 | 0.96 | FALSE |
| 9 | GTEx | Nerve Tibial | UBOX5 | 0.14 | 0.05 | lasso | 5 | 0.08 | 4.2e-06 | 5.0 | -5.2 | 2.0e-07 | 0.03 | 0.02 | 0.98 | FALSE |
| 10 | GTEx | Thyroid | UBOX5 | 0.15 | 0.07 | lasso | 2 | 0.12 | 1.2e-09 | -5.1 | -5.3 | 1.4e-07 | 0.03 | 0.01 | 0.99 | FALSE |
| 11 | NTR | Blood | SMOX | 0.06 | 0.03 | lasso | 4 | 0.03 | 6.5e-11 | 6.6 | -6.3 | 2.4e-10 | -0.95 | 0.00 | 1.00 | FALSE |
| 12 | ROSMAP | Brain Pre-frontal Cortex | UBOX5 | 0.26 | 0.17 | lasso | 8 | 0.16 | 4.1e-20 | -5.0 | -5.2 | 2.0e-07 | 0.04 | 0.01 | 0.99 | FALSE |
| 13 | YFS | Blood | FASTKD5 | 0.02 | 0.01 | lasso | 6 | 0.01 | 2.2e-05 | -5.1 | 5.6 | 1.9e-08 | -0.04 | 0.01 | 0.99 | FALSE |
| 14 | YFS | Blood | SMOX | 0.44 | 0.37 | enet | 54 | 0.42 | 4.0e-154 | 6.6 | -6.4 | 2.1e-10 | -0.92 | 0.00 | 1.00 | TRUE |
| 15 | The Cancer Genome Atlas | Colon Adenocarcinoma | SIGLEC1 | 0.12 | 0.06 | blup | 86 | 0.06 | 1.8e-04 | 4.3 | -5.6 | 2.4e-08 | 0.01 | 0.82 | 0.05 | FALSE |
| 16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ADAM33 | 0.07 | 0.03 | enet | 9 | 0.04 | 1.9e-05 | 5.9 | 6.1 | 9.3e-10 | -0.03 | 0.02 | 0.98 | TRUE |
| 17 | The Cancer Genome Atlas | Lung Adenocarcinoma | ADAM33 | 0.05 | 0.02 | blup | 78 | 0.04 | 2.9e-05 | -2.0 | 6.2 | 6.1e-10 | -0.08 | 0.20 | 0.29 | TRUE |
| 18 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | ADRA1D | 0.13 | 0.01 | blup | 76 | 0.02 | 3.7e-02 | -3.0 | 5.5 | 4.6e-08 | 0.49 | 0.01 | 0.17 | FALSE |