Hub : Genes

ADRA1D

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1800 0.0370 1.4e-09 0.108 0.072 0.151 0.126 0.127 4.9e-13 4.2e-09 5.4e-18 4.9e-15 3.4e-15
2 ROSMAP Brain Pre-frontal Cortex 0.2169 0.0381 1.5e-10 0.128 0.094 0.114 0.125 0.146 3.6e-16 3.8e-12 1.8e-14 8.7e-16 2.5e-18
3 TCGA Breast Invasive Carcinoma 0.0373 0.0178 2.0e-03 0.000 0.011 0.007 NA 0.003 3.9e-01 1.9e-03 1.0e-02 NA 8.1e-02
4 TCGA Pancreatic Adenocarcinoma 0.1330 0.0670 9.4e-03 0.007 0.023 0.005 NA 0.008 1.6e-01 3.7e-02 2.0e-01 NA 1.4e-01
5 TCGA Stomach Adenocarcinoma 0.1180 0.0510 1.2e-03 -0.001 0.035 0.020 NA 0.015 3.6e-01 1.3e-03 1.3e-02 NA 2.8e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.2 0.3 0.9 0.7 1.0 0.1 -0.2 0.4
Bipolar Disorder or Schizophrenia 0.5 1.2 3.5 1.1 1.9 0.6 1.0 -0.2
Depressed Affect (Nagel 2018) 0.2 0.4 1.5 0.5 1.2 -0.1 -0.2 -0.7
Depression (Nagel 2018) 1.0 1.6 3.3 0.8 1.8 0.8 1.8 -0.4
Intelligence (Savage-Jansen 2018) 0.1 0.4 1.1 0.5 -0.1 -1.0 -0.3 0.6
Neuroticism (Nagel 2018) 0.2 0.4 1.0 0.1 0.7 0.6 0.3 -1.0
Schizophrenia (2018) 0.6 1.2 2.4 0.8 1.5 0.7 1.4 -0.5
Schizophrenia vs Biploar Disorder 0.9 1.2 4.9 0.2 0.2 -0.7 -0.5 -2.2
Worry (Nagel 2018) 0.2 0.5 1.0 -0.9 -0.5 0.3 0.5 -1.0
Alzheimer’s Disease (in mother) 0.3 0.4 1.0 -0.3 0.4 0.7 0.4 1.0
Alzheimer’s Disease (in father) 1.0 1.1 3.4 -1.1 -0.1 -0.7 -0.4 -1.9
Alzheimer’s Disease (including proxy) 0.3 0.4 0.9 -0.7 0.8 -0.2 -0.3 -0.9
Crohns Disease (2017) 1.0 2.2 5.7 -0.1 -0.8 -2.4 -1.9 1.1
Irritable Bowel Disease (IBD) 0.2 0.5 1.5 0.1 -0.6 -0.8 -0.5 1.2
Ulcerative Colitis (UC) 0.1 0.2 0.4 0.2 0.1 0.7 0.6 0.4
Major Depression (MDD) 1.2 1.4 2.2 1.1 1.0 1.3 1.5 -1.0
Reaction Time 0.7 1.4 2.8 1.7 1.1 0.5 1.1 1.1
Verbal and Numeric Reasoning (VNR) 0.5 1.3 2.7 1.6 0.6 -1.6 -0.9 -0.2
Breast Cancer 0.2 0.6 1.5 0.5 0.0 -0.7 -0.7 1.2
Ovarian Cancer 0.9 1.2 4.8 -0.1 0.6 -0.7 -0.5 -2.2
Prostate Cancer 1.2 1.7 7.1 0.6 0.6 0.4 0.6 -2.7
Age at First Birth 0.8 1.1 2.6 1.6 1.2 0.4 0.8 -0.8
Bipolar Disorder (2011) 0.9 0.9 1.8 0.6 1.3 0.9 1.0 0.6
Body Mass Index (BMI) (2010) 0.4 0.5 1.0 -1.0 0.2 0.9 0.4 0.8
Coronary Artery Disease (CAD) 1.4 1.6 4.5 0.6 0.7 1.6 2.1 -0.4
Crohns Disease (2012) 1.1 1.8 5.1 0.9 1.1 -2.3 -1.1 0.9
Mean Putamen Volume 1.0 1.2 3.2 -1.2 -1.8 0.6 -0.4 0.9
Fasting Glucose 0.3 0.3 1.1 -0.1 -0.2 1.1 0.6 0.1
HbA1C 0.6 0.7 1.5 -0.6 -1.2 -0.4 -0.1 1.2
HDL Cholesterol 1.9 3.1 7.1 -0.4 -0.1 -2.7 -1.6 -2.4
LDL Cholesterol 0.5 0.8 1.6 -0.3 -0.8 1.3 1.1 0.6
Lupus 0.2 0.4 0.7 0.9 0.1 -0.6 -0.4 0.7
Neuroticism (2016) 0.8 1.2 3.4 0.6 1.0 1.8 1.2 0.1
Primary Biliary Cirrhosis 0.9 1.3 2.1 1.4 1.2 0.6 1.0 -1.4
Rheumatoid Arthritis 0.3 0.5 0.9 -0.6 -0.7 0.5 0.6 0.9
Schizophrenia (2014) 0.8 1.7 3.9 0.9 2.0 0.2 1.2 -1.5
Triglycerides 0.3 0.6 1.4 0.3 0.4 1.2 0.7 0.8
Type 2 Diabetes (T2D) (2012) 2.1 2.4 9.3 0.3 -1.3 0.1 1.0 3.0
Ulcerative Colitis 0.4 0.6 1.9 -0.5 0.4 0.7 1.4 0.4
Blood Eosinophil Count 0.2 1.7 7.2 0.5 -0.3 -0.9 -0.7 2.7
Blood Platelet Count 0.9 10.7 19.0 1.7 2.3 4.4 4.4 2.7
Blood Red Count 0.0 0.2 0.4 -0.2 -0.5 -0.2 -0.5 -0.7
Blood White Count 1.8 13.1 29.9 3.5 3.1 3.6 5.5 -0.7
Heel T-Score 0.4 3.5 6.2 -2.3 -2.5 1.2 -2.0 0.6
BMI 1.2 7.1 11.7 3.1 2.9 2.2 3.4 -0.9
Height 0.4 8.1 25.3 -1.9 -1.5 -5.0 -3.1 -0.1
Waist Hip Ratio (WHR) 0.4 1.7 3.7 -1.0 -0.7 -1.9 -0.8 -1.6
Systolic Blood Pressure 0.4 2.2 7.7 -1.8 0.1 -0.0 -0.5 -2.8
Smoking Status 0.7 1.6 5.6 -0.9 -0.2 0.6 1.2 -2.4
Allergy or Eczema 1.1 2.9 4.9 -0.9 -1.5 -2.2 -2.1 -1.4
Cardiovascular Disease 0.3 1.1 2.1 -1.5 -1.3 0.8 -0.4 -0.9
Hypothyroidism (self reported) 1.3 2.9 4.9 2.2 1.9 1.2 2.2 -0.0
Respiratory disease 0.4 0.8 2.9 -0.1 0.0 0.2 -1.0 1.7
Type 2 Diabetes (T2D) (2018) 0.9 1.7 2.7 1.6 1.1 -0.3 1.3 -1.6
Lung FEV1/FVC ratio 0.1 0.5 0.9 0.1 0.9 -0.7 -0.4 0.9
Lung FVC 0.1 0.7 1.5 1.1 0.0 -0.8 -1.2 0.0
Neuroticism 0.3 0.7 1.2 -0.2 0.6 1.1 0.8 -1.1
Chronotype (morning person) 1.9 4.5 12.2 -2.3 -3.5 -0.5 -2.0 1.1
Hair Pigment 0.0 0.6 0.9 1.0 0.9 0.3 0.7 -0.8
Tanning 0.2 2.4 6.7 -2.2 -2.6 0.4 0.4 0.6
Hand grip strength (left) 0.5 1.2 3.3 1.1 1.1 -1.8 -0.6 -0.3
Number of treatments/medications taken 1.0 1.8 5.6 0.3 -0.4 1.4 1.2 2.4
Average weekly spirits intake 0.5 0.6 1.4 -0.0 -0.1 -1.0 -0.8 -1.2
Sensitivity / hurt feelings 0.2 0.3 0.7 -0.4 -0.8 0.5 -0.4 -0.4
Frequency of depressed mood in last 2 weeks 0.7 1.0 3.1 -0.1 0.4 1.4 1.8 -0.0
Hearing difficulty/problems: Yes 0.7 1.1 2.8 1.0 0.7 -1.7 -0.6 0.9
Relative age of first facial hair 0.2 0.5 1.1 0.8 0.4 -1.1 -0.4 -0.4
Other serious medical condition/disability diagnosed by doctor 0.8 1.0 4.6 -0.4 -0.2 -0.5 -0.1 2.1
Ever used hormone-replacement therapy (HRT) 0.6 0.7 1.9 -0.3 -0.7 1.1 -0.2 1.4
Ever had hysterectomy (womb removed) 1.5 1.6 3.0 -1.7 -1.2 -0.9 -1.7 -0.3
Systolic blood pressure, automated reading 0.5 1.5 2.2 0.8 1.5 1.2 1.1 -1.4
Eye problems/disorders: Diabetes related eye disease 1.7 1.9 6.3 -0.6 -0.5 2.5 1.3 -0.9
Angina 0.9 1.2 2.1 -1.3 -1.5 -0.8 -0.9 -0.8
Medication for hormone replacement therapy 0.6 0.7 1.2 -1.0 -0.3 1.1 0.2 1.0
Vitamin and mineral supplements 0.3 0.4 1.2 0.6 0.4 1.1 0.4 0.1
Supplements: Zinc 1.1 1.2 2.0 -1.1 -1.2 1.3 0.2 1.4
Medication: Co-codamol 0.5 0.6 0.9 -0.2 -0.9 0.9 0.9 -0.7
Medication: Metformin 1.4 2.0 3.6 1.4 1.5 1.4 1.9 -0.4
Diabetes (father) 0.4 0.5 1.3 0.5 1.1 0.8 0.6 -0.3
Diabetes (mother) 0.8 1.1 2.2 1.5 0.9 0.6 0.7 -1.1
Severe depression (siblings) 1.6 1.8 4.0 1.5 2.0 -0.0 0.9 1.4
Pack years adult smoking proportion 1.0 1.5 3.5 1.2 0.2 0.9 1.9 -1.3
Impedance of leg (right) 0.5 2.2 5.8 -2.4 -2.1 -0.0 -0.8 0.1
Leg fat-free mass (left) 0.2 1.0 2.3 1.5 0.5 -1.5 -0.2 -0.2
Trunk fat percentage 0.6 2.4 6.2 1.8 0.9 1.3 2.5 -0.4
Hand grip strength (right) 0.6 1.6 5.2 0.8 -0.1 -2.3 -1.3 0.6
Townsend deprivation index at recruitment 0.7 1.0 2.4 1.5 0.5 1.0 0.8 -0.8
Current tobacco smoking 0.8 1.4 2.7 1.3 1.3 -0.1 0.9 -1.7
Average weekly fortified wine intake 0.2 0.2 0.6 -0.3 -0.2 -0.8 -0.5 -0.0
Maternal smoking around birth 0.3 0.4 0.8 -0.1 -0.7 -0.9 -0.3 0.8
Fed-up feelings 0.6 1.0 4.1 0.9 2.0 0.2 0.1 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 2.0 2.7 5.2 1.1 1.7 2.0 2.3 0.6
Relative age voice broke 0.2 0.3 0.9 -0.4 -0.1 0.3 1.0 -0.4
Taking other prescription medications 0.3 0.4 0.9 0.9 0.3 0.4 0.7 0.8
Age when periods started (menarche) 0.5 1.3 2.7 1.2 1.6 -0.0 0.1 1.5
Bilateral oophorectomy (both ovaries removed) 0.9 1.0 2.9 -1.0 -0.2 1.7 1.0 0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 2.5 -1.6 -1.1 0.6 -1.1 -1.2
Tinnitus: Yes, but not now, but have in the past 2.0 2.1 5.2 0.0 0.2 1.9 1.4 2.3
Qualifications: CSEs or equivalent 0.5 0.7 1.3 -0.6 -0.4 -0.7 -1.1 1.1
Serious illness, injury or assault to yourself 1.1 1.3 5.6 0.4 -0.4 -0.8 -0.3 2.4
High blood pressure 0.1 0.3 0.6 -0.4 -0.8 0.7 0.3 -0.1
Hayfever, allergic rhinitis or eczema 2.0 4.4 6.1 -1.7 -1.5 -2.3 -2.3 -2.5
Multivitamins +/- minerals 0.1 0.1 0.3 0.1 0.3 0.0 0.6 -0.5
Stomach or abdominal pain in last month 0.1 0.1 0.4 -0.4 -0.3 0.0 -0.0 0.7
Supplements: Glucosamine 0.7 1.0 2.0 1.3 0.1 1.4 1.1 -0.1
Diverticular disease/diverticulitis (self-reported) 0.9 1.1 2.1 0.8 0.7 -1.4 -1.5 -0.4
Medication: Atenolol 1.6 2.0 7.0 1.1 1.1 -0.6 -0.5 -2.6
Medication: Levothyroxine sodium 0.2 0.3 0.9 1.0 -0.1 0.6 0.5 0.4
Sitting height 0.7 4.9 8.5 -1.6 -2.3 -2.9 -2.9 -0.0
Chronic bronchitis/emphysema (father) 0.2 0.2 0.6 0.0 0.6 0.8 -0.1 0.2
High blood pressure (mother) 1.0 1.4 2.5 -0.2 -1.2 -0.9 -1.5 -1.6
Body mass index (BMI) 0.9 3.9 6.4 2.5 1.9 1.8 2.5 -0.6
Impedance of leg (left) 0.6 3.0 7.6 -2.8 -2.3 -0.5 -1.4 0.3
Leg predicted mass (left) 0.2 1.0 2.3 1.5 0.4 -1.5 -0.2 -0.2
Trunk fat mass 0.4 1.7 3.9 1.9 0.8 0.5 2.0 -0.3
Waist circumference 0.9 3.2 5.6 2.4 2.1 0.7 2.1 -1.0
Number of incorrect matches in round 0.9 1.5 3.2 -1.4 -0.9 1.8 0.8 1.0
Past tobacco smoking 0.7 1.2 4.3 -0.5 -0.5 -0.6 -1.0 2.1
Alcohol usually taken with meals 0.8 1.3 5.6 -0.2 -0.5 -0.7 -0.6 2.4
Nervous feelings 0.6 1.0 1.6 -1.1 -1.1 1.3 0.5 -0.9
Frequency of tenseness / restlessness in last 2 weeks 1.9 2.9 5.9 1.3 2.4 1.4 1.9 -1.1
Hearing difficulty/problems with background noise 0.7 1.1 2.5 1.3 1.1 -0.6 0.1 -1.6
Hair/balding pattern: Pattern 2 0.1 0.2 0.7 -0.1 -0.8 -0.2 0.1 0.1
Had menopause 1.2 1.6 2.3 1.5 1.2 1.4 1.4 -0.0
Had other major operations 0.8 1.0 3.5 -1.9 -0.9 -0.2 -0.6 -0.7
Forced vital capacity (FVC) 0.7 2.6 7.0 -0.9 -0.9 -1.9 -2.6 0.9
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.3 2.4 -1.6 -1.3 0.2 -1.3 -0.8
Ever unenthusiastic/disinterested for a whole week 2.5 3.0 6.8 1.7 2.1 0.3 2.6 -1.0
Qualifications: None of the above 0.9 2.0 9.0 0.2 0.4 0.7 0.5 -3.0
Financial difficulties in last 2 years 0.7 1.0 2.2 0.1 1.1 1.1 1.5 0.5
Mouth/teeth dental problems 0.1 0.1 0.5 0.0 -0.1 -0.1 -0.3 0.7
Heart attack 0.4 0.5 1.9 -0.1 -0.7 0.3 0.3 1.4
Allergy 1.5 3.3 4.1 2.0 1.6 1.4 2.0 2.0
Pain all over the body in last month 2.4 2.6 4.6 -1.4 -2.1 1.5 -0.3 2.0
Diabetes (self-reported) 1.2 1.9 3.0 1.5 1.5 0.4 1.7 -1.3
Hayfever/allergic rhinitis (self-reported) 3.0 3.9 7.8 0.6 1.8 -2.8 -1.2 -2.6
Medication: Ramipril 0.2 0.3 0.9 0.4 -0.1 -0.1 -0.9 0.4
Medication: Simvastatin 0.2 0.4 1.0 0.4 -1.0 -0.5 -0.2 0.5
Fluid intelligence score 0.7 1.5 2.8 1.2 1.6 -1.7 -0.0 -0.7
Illnesses of siblings 1.8 2.6 6.9 0.2 1.7 -1.4 -1.0 -2.6
Neuroticism score 0.2 0.3 0.8 -0.6 0.4 0.6 0.1 -0.9
Weight 0.3 1.2 4.2 2.0 1.0 -0.5 0.9 -0.3
Impedance of arm (right) 0.1 0.3 1.3 0.2 0.4 -0.4 -0.0 -1.1
Arm fat percentage (right) 1.6 6.2 11.7 3.0 2.3 1.9 3.4 -1.3
Trunk fat-free mass 0.3 1.5 5.3 0.8 -0.2 -2.3 -1.1 0.5
Hip circumference 0.6 2.8 7.2 2.7 1.8 0.3 1.8 -0.2
Time employed in main current job 2.0 2.3 5.8 -1.2 -2.0 -0.0 0.1 2.4
Alcohol intake versus 10 years previously 0.6 0.9 3.0 1.7 0.7 -0.1 -0.6 -0.6
Father’s age at death 0.6 0.8 2.5 1.6 0.7 -0.9 0.1 0.5
Worrier / anxious feelings 0.2 0.3 1.0 -1.0 -0.5 0.4 -0.2 -0.0
Frequency of tiredness / lethargy in last 2 weeks 1.3 2.1 4.3 0.6 1.3 2.0 2.1 0.0
Falls in the last year 0.3 0.4 1.1 -0.3 0.7 -1.1 0.2 -0.2
Hair/balding pattern: Pattern 3 0.2 0.2 0.7 -0.8 -0.4 0.5 -0.2 -0.1
Number of live births 1.3 1.9 4.5 0.4 0.5 -1.6 -2.1 -1.3
Forced expiratory volume in 1-second (FEV1) 0.7 2.4 6.2 -0.9 -0.7 -1.8 -2.5 1.0
Pulse rate 0.7 1.1 4.0 -2.0 -1.0 0.8 0.0 -0.1
Happiness 1.6 2.0 4.7 0.6 1.6 0.9 2.2 -1.2
Noisy workplace 0.8 0.9 2.5 -0.3 -1.4 0.2 -0.2 1.6
Qualifications: A levels/AS levels or equivalent 0.4 0.9 1.8 -0.1 -0.6 -1.2 -0.8 1.3
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.3 3.4 1.1 0.7 -1.8 -0.8 -0.9
Mouth/teeth dental problems: Dentures 0.4 0.6 1.7 0.5 1.3 0.3 0.7 -0.7
Asthma 0.1 0.2 0.4 -0.6 0.1 0.6 -0.6 0.2
Medication: Ibuprofen (e.g. Nurofen) 1.7 2.2 5.9 -1.4 -1.1 -1.3 -2.4 0.1
Medication: Cholesterol lowering 0.7 1.1 3.5 -0.0 -0.8 1.1 0.4 1.9
Depression (self-reported) 0.1 0.2 0.4 -0.3 -0.1 0.7 0.3 -0.5
Medication: Lansoprazole 2.4 2.7 9.0 2.0 3.0 -0.2 0.3 -0.5
Prospective memory result 0.6 0.7 1.5 -1.2 -0.4 0.7 1.2 -0.0
Lung cancer (father) 0.1 0.1 0.3 0.5 0.3 0.3 -0.0 -0.5
Illnesses of mother 0.2 0.3 0.6 -0.5 -0.2 0.7 0.3 0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.7 4.4 -0.5 -0.6 -1.6 -2.1 1.0
Pulse wave Arterial Stiffness index 1.2 1.4 5.7 0.4 0.2 -0.2 -1.0 -2.4
Impedance of arm (left) 0.1 0.4 1.0 -0.4 -0.2 -0.8 -0.5 -1.0
Arm fat mass (right) 0.8 3.4 7.5 2.7 1.7 0.9 2.2 -0.8
Trunk predicted mass 0.3 1.5 5.5 0.8 -0.3 -2.4 -1.1 0.5
Standing height 0.8 7.5 22.6 -0.8 -1.7 -4.8 -3.3 0.5
Length of working week for main job 1.2 1.3 5.7 -0.9 -0.5 0.1 -0.0 2.4
Exposure to tobacco smoke at home 0.3 0.3 1.0 -1.0 0.1 -0.1 -0.1 -0.8
Breastfed as a baby 0.2 0.2 0.5 0.2 0.7 -0.7 -0.3 0.1
Tense / ‘highly strung’ 1.1 1.8 2.4 -1.3 -1.0 1.5 1.2 1.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.4 1.0 -0.9 -0.2 0.4 0.3 -1.0
Hair/balding pattern: Pattern 4 1.7 4.1 12.9 -1.4 -0.6 -1.1 -2.1 3.6
Birth weight of first child 0.2 0.4 1.4 -0.0 -0.0 -0.8 -1.2 0.0
Peak expiratory flow (PEF) 0.4 0.9 1.5 -1.2 -1.1 -0.0 -0.6 1.2
Pulse wave reflection index 1.2 1.5 4.5 -0.3 -1.0 -0.1 -1.4 -2.1
Ever highly irritable/argumentative for 2 days 2.1 2.5 4.3 1.6 1.4 0.7 2.1 -1.8
Loud music exposure frequency 0.4 0.4 0.7 0.8 0.5 0.5 0.9 0.3
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 1.3 0.4 0.2 -1.2 -0.9 0.7
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 0.7 0.1 0.1 0.7 0.9 -0.2
Blood clot in the leg (DVT) 0.7 0.9 3.7 -0.5 -0.5 0.2 0.5 -1.9
Medication: Paracetamol 0.8 1.4 4.0 0.8 0.8 0.7 2.0 1.1
Headache pain in last month 1.3 2.3 6.4 0.5 -0.4 -2.0 -2.5 0.8
Medication for cholesterol, blood pressure or diabetes 1.5 2.5 4.3 1.5 2.0 -1.2 -0.8 -2.1
Glaucoma (self-reported) 0.1 0.1 0.4 0.2 0.6 0.1 -0.1 0.4
Gout (self-reported) 0.9 1.2 2.6 1.1 1.4 1.6 0.4 0.5
Hypothyroidism/myxoedema (self-reported) 0.6 1.1 1.8 1.3 0.6 0.8 1.3 1.1
Medication: Amlodipine 1.9 2.7 5.5 -1.3 -0.3 2.4 1.8 -1.7
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.9 0.8 0.9 0.1 0.2 0.7
Birth weight 0.3 0.8 1.8 1.0 0.7 -0.6 -0.2 1.4
Chronic bronchitis/emphysema (mother) 0.7 0.8 1.7 -1.3 -0.6 -0.9 -1.0 0.2
High blood pressure (siblings) 0.7 0.9 2.7 -0.2 -1.2 0.7 0.1 1.6
Forced vital capacity (FVC), Best measure 0.8 2.8 6.9 -0.8 -1.1 -2.1 -2.6 0.9
Body fat percentage 0.9 3.5 8.6 2.0 1.3 1.7 2.9 -0.7
Leg fat percentage (right) 1.0 3.5 7.6 2.2 1.2 1.8 2.8 -0.5
Arm fat-free mass (right) 0.3 1.5 5.2 0.5 -0.5 -2.3 -1.2 0.5
Exposure to tobacco smoke outside home 1.0 1.3 6.1 -0.1 0.0 -0.4 -0.6 -2.5
Comparative body size at age 10 0.4 1.2 2.8 1.7 0.2 -1.5 -0.8 0.3
Number of full brothers 0.7 0.8 2.6 -0.9 -1.6 0.4 0.0 -0.7
Worry too long after embarrassment 0.8 1.3 4.4 -0.4 -0.3 -0.9 -1.1 -2.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 2.7 -0.3 0.7 0.8 1.6 -0.5
Wheeze or whistling in the chest in last year 1.9 3.4 7.6 2.7 2.8 -1.2 0.3 -0.7
Number of children fathered 1.5 1.7 4.9 0.6 -0.4 1.3 1.0 2.2
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 0.7 -0.4 0.0 0.8 0.8 0.2
Age at first live birth 0.3 0.6 1.3 1.0 1.2 -0.2 0.7 -0.2
Pulse wave peak to peak time 1.2 1.4 6.2 -0.4 -0.2 -0.1 0.9 2.5
Health satisfaction 0.1 0.1 0.2 -0.3 -0.3 0.3 0.4 -0.1
Shortness of breath walking on level ground 1.6 2.0 5.5 -0.6 0.0 1.7 1.1 2.3
Qualifications: College or University degree 0.2 0.7 2.6 -0.3 -0.6 -0.2 0.8 1.6
Eye problems/disorders: None of the above 0.5 0.6 1.3 -0.3 0.4 -1.1 -0.9 -0.9
Mouth/teeth dental problems: Loose teeth 1.3 1.5 4.3 -0.6 -0.7 1.4 0.7 2.1
Emphysema/chronic bronchitis 0.0 0.0 0.1 0.0 0.1 0.1 0.2 -0.1
Medication for pain relief, constipation, heartburn 1.0 1.7 4.0 0.8 1.9 -0.6 -0.4 -2.0
Neck or shoulder pain in last month 0.7 1.0 1.8 -1.2 -0.6 1.0 0.5 1.3
Medication: Blood pressure 1.6 2.8 4.8 -2.2 -2.1 1.6 0.7 1.3
Angina (self-reported) 0.9 1.2 2.5 -1.4 -1.6 -0.7 -0.8 -0.6
Migraine (self-reported) 1.4 1.7 3.7 0.9 0.2 1.8 0.9 1.9
Medication: Ibuprofen 1.5 1.8 3.8 -1.7 -1.1 -0.5 -2.0 1.1
Medication: Allopurinol 0.4 0.6 1.1 0.8 1.0 1.1 0.3 0.3
Medication: Omeprazole 0.9 1.1 2.6 -0.7 -1.6 1.4 0.5 0.4
Medication: Seretide 50 evohaler 0.4 0.5 0.8 0.1 0.9 0.4 -0.8 -0.8
Mean time to correctly identify matches 0.7 1.4 4.5 2.1 1.2 0.4 0.9 0.4
Heart disease (mother) 0.1 0.1 0.3 -0.2 -0.1 0.4 0.5 -0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.7 -0.8 -0.5 -0.1 -0.2 -0.1
Whole body fat mass 0.5 2.0 4.9 1.9 0.9 1.0 2.2 -0.2
Leg fat mass (right) 0.5 2.0 4.2 1.9 0.9 1.0 2.1 -0.5
Arm predicted mass (right) 0.3 1.3 4.1 0.4 -0.7 -2.0 -1.1 0.7
Pulse rate, automated reading 0.3 1.0 1.8 -1.1 0.4 1.2 1.3 -0.3
Alcohol intake frequency. 0.8 1.8 3.7 1.9 1.5 0.7 1.4 0.5
Comparative height size at age 10 0.7 3.7 11.7 0.4 -0.7 -3.4 -2.3 -0.9
Number of full sisters 0.2 0.3 0.7 -0.4 -0.6 -0.4 -0.8 0.3
Suffer from ‘nerves’ 0.3 0.4 1.4 -0.4 0.7 0.0 -0.2 -1.2
Overall health rating 0.2 0.4 0.8 -0.9 -0.6 0.9 0.3 0.2
Chest pain or discomfort 1.0 1.4 3.3 0.2 0.4 1.0 1.6 1.8
Had major operations 2.4 2.8 6.3 -2.0 -2.5 0.5 -1.0 1.6
Age at last live birth 1.1 1.6 4.3 2.1 1.6 -0.9 0.4 -0.4
Family relationship satisfaction 1.0 1.3 2.3 -0.7 1.1 0.8 1.5 -1.3
Leg pain on walking 0.5 0.7 2.2 0.2 -0.4 0.3 1.5 0.9
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.8 1.7 -1.3 -1.1 1.0 0.3 0.4
Commuting to job workplace: Car/motor vehicle 1.8 2.1 3.8 -1.9 -1.8 -0.7 -1.6 0.5
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 1.1 -0.1 -0.4 -0.4 -1.1 0.1
Medication: Aspirin 2.2 2.9 7.4 -1.4 -2.7 0.4 1.0 2.0
Supplements: Vitamin C 0.3 0.4 0.7 -0.5 -0.8 -0.6 -0.1 0.8
Knee pain experienced in last month 0.7 1.1 2.7 0.3 1.6 1.5 0.6 -0.0
Hypertension (Self-reported) 0.1 0.3 0.7 -0.5 -0.8 0.4 -0.1 -0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.7 3.2 7.1 -1.2 -2.3 1.4 -0.2 2.7
Illnesses of father: Heart disease 0.1 0.1 0.2 0.0 -0.4 0.4 0.3 -0.1
Illnesses of siblings: Diabetes 0.2 0.2 0.4 -0.3 -0.3 0.7 0.6 0.6
Smoking status: Previous 0.6 0.9 1.8 -1.1 -0.6 0.7 0.6 -1.3
Forced expiratory volume in 1-second (FEV1), predicted 1.4 3.0 5.8 -0.9 -1.4 -2.4 -2.4 -0.8
Whole body fat-free mass 0.2 1.3 4.7 1.1 0.0 -2.2 -0.8 0.4
Leg fat-free mass (right) 0.2 1.2 3.6 1.3 0.5 -1.9 -0.6 -0.2
Arm fat percentage (left) 1.3 5.2 9.8 2.8 2.1 1.6 3.1 -1.3
Average weekly red wine intake 2.4 3.6 6.8 1.2 1.1 2.6 2.4 1.7
Handedness (chirality/laterality): Left-handed 2.3 2.7 6.5 1.7 1.5 -1.3 0.4 -2.5
Mood swings 0.3 0.5 1.2 0.6 0.2 1.0 1.1 0.2
Loneliness, isolation 0.3 0.5 1.2 -0.2 1.1 0.2 0.2 -1.0
Long-standing illness, disability or infirmity 1.3 2.0 3.2 -0.7 0.2 1.8 1.7 1.8
Ever had bowel cancer screening 0.5 0.6 2.3 -0.2 -1.5 -0.2 -0.7 0.1
Diabetes diagnosed by doctor 1.8 2.9 4.4 2.0 2.1 -0.2 1.6 -1.9
Ever had stillbirth, spontaneous miscarriage or termination 1.5 1.6 4.0 -0.1 -0.1 -1.3 -1.5 -2.0
Friendships satisfaction 0.9 1.1 1.8 0.1 0.6 1.3 1.2 -1.3
Qualifications: nursing, teaching 0.4 0.5 1.1 1.0 -0.2 -1.1 -0.7 0.2
Commuting to job workplace: Walk 1.0 1.1 2.7 0.2 0.2 1.6 1.5 0.7
Eye problems/disorders: Cataract 1.0 1.1 2.1 0.2 -0.7 1.4 1.1 1.4
Mouth/teeth dental problems: Mouth ulcers 1.1 1.8 2.5 -1.2 -1.6 -1.2 -1.5 -1.1
Medication for cholesterol 0.1 0.2 0.4 -0.0 0.5 0.6 0.6 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.4 1.6 3.5 -1.9 -1.3 0.9 -0.3 1.4
Back pain experienced in last month 0.7 1.0 4.0 -0.9 0.1 -0.5 -0.1 2.0
Mineral and other dietary supplements 1.3 1.7 3.3 1.2 1.8 -0.8 -0.5 -1.7
Breast cancer (self-reported) 0.6 0.7 1.2 0.9 1.1 0.3 0.8 0.8
Asthma (self-reported) 0.1 0.3 0.8 -0.3 0.2 0.3 -0.9 0.6
Osteoporosis (self-reported) 0.1 0.1 0.3 0.6 0.4 0.3 0.0 0.2
Osteoarthritis (self-reported) 0.6 0.8 2.6 -0.7 0.3 1.6 0.7 0.7
Medication: Aspirin 1.8 2.3 6.7 -1.3 -2.6 0.2 0.8 1.6
Medication: Gliclazide 0.5 0.5 1.1 -1.0 -0.8 -0.5 -0.3 -0.9
Illnesses of father: None of the above (group 1) 0.7 0.9 1.6 1.0 1.2 -0.6 1.0 -0.6
Smoking status: Current 0.7 1.1 2.1 1.2 1.1 -0.1 0.7 -1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 1.6 -1.1 -1.3 0.6 -0.4 0.8
Whole body water mass 0.2 1.3 4.5 1.0 -0.0 -2.1 -0.8 0.3
Leg predicted mass (right) 0.2 1.2 3.7 1.3 0.4 -1.9 -0.6 -0.1
Arm fat mass (left) 0.7 2.8 5.6 2.4 1.4 0.9 2.2 -0.9
Number of self-reported non-cancer illnesses 0.4 0.8 1.3 -0.5 -1.2 -0.2 -1.0 1.1
Average weekly champagne plus white wine intake 0.3 0.5 1.2 0.6 1.1 0.2 0.9 -0.0
Miserableness 0.6 1.0 3.0 1.2 1.7 -0.5 -0.1 -0.6
Guilty feelings 1.3 1.9 4.0 -2.0 -1.9 0.5 -0.9 1.0
Wears glasses or contact lenses 0.5 0.5 1.7 1.3 0.6 0.4 0.6 0.1
Ever taken oral contraceptive pill 1.3 1.4 3.9 -1.2 -0.1 0.8 1.1 -2.0
Hearing aid user 1.0 1.2 2.0 1.1 1.3 0.9 1.4 -0.1
Mother’s age at death 0.5 0.6 1.4 0.5 0.8 0.5 1.2 -0.7
Financial situation satisfaction 0.5 0.6 1.1 -1.1 -0.2 0.8 0.8 -0.6
Tinnitus: Yes, now most or all of the time 0.1 0.2 0.6 0.1 0.3 -0.8 -0.1 -0.1
Commuting to job workplace: Public transport 2.0 2.4 4.5 1.9 1.9 0.4 2.1 0.4
Eye problems/disorders: Glaucoma 0.8 1.0 1.5 -1.2 -1.1 -0.8 -1.1 -0.5
Medication: Blood pressure 0.1 0.1 0.5 0.2 -0.7 -0.1 -0.4 0.1
Pain type(s) experienced in last month: Hip pain 0.3 0.4 1.1 0.3 0.9 -0.1 0.1 -1.1
Supplements: Fish oil (including cod liver oil) 1.0 1.3 3.1 -1.1 -1.7 0.4 0.0 1.4
High cholesterol (Self-reported) 0.2 0.4 1.0 1.0 0.2 0.1 -0.3 0.9
Medication: Bendroflumethiazide 0.1 0.2 0.4 0.6 0.1 0.4 -0.3 -0.4
Medication: Paracetamol 1.4 2.1 3.4 1.3 1.9 1.0 1.8 1.1
Medication: Lisinopril 1.3 1.7 4.7 -0.9 -1.3 0.8 0.8 2.2
Medication: Atorvastatin 0.9 1.1 2.7 1.0 1.7 0.7 0.7 -0.8
Illnesses of father: High blood pressure 2.2 2.7 7.0 -1.4 -2.6 -0.2 -2.0 0.8
Alcohol drinker status: Never 3.3 3.9 7.3 0.2 1.5 2.6 2.7 1.8
Ever smoked 1.5 2.7 6.8 1.8 1.7 0.1 0.6 -2.6
Basal metabolic rate 0.2 0.9 2.9 1.1 0.1 -1.7 -0.5 0.1
Leg fat percentage (left) 0.8 2.8 6.2 1.9 1.0 1.7 2.5 -0.3
Arm fat-free mass (left) 0.2 0.8 2.4 0.9 -0.3 -1.6 -0.7 0.5
Number of operations (self-reported) 1.3 1.9 3.6 -1.9 -1.8 -0.4 -1.6 -0.3
Average weekly beer plus cider intake 1.6 2.4 6.5 1.9 2.6 -0.2 0.7 -1.0
Irritability 1.1 1.9 3.7 0.5 1.9 1.7 1.6 0.0
Risk taking 0.4 0.6 1.3 -0.2 -1.1 -1.1 -0.6 -0.3
Ever had prostate specific antigen (PSA) test 0.5 0.6 2.1 0.3 -0.0 -1.4 -0.7 0.5
Fractured/broken bones in last 5 years 1.1 1.4 3.0 0.9 1.0 -1.4 -0.0 -1.7
Age started oral contraceptive pill 1.1 1.4 5.8 2.4 0.8 -0.7 -0.2 0.1
Diastolic blood pressure, automated reading 0.2 0.6 1.8 -0.3 -0.2 1.3 0.6 -0.8
Ever depressed for a whole week 0.7 0.9 3.6 0.4 0.6 -0.1 1.9 -0.6
Unable to work because of sickness or disability 0.6 0.7 1.6 -1.3 -0.6 0.9 0.7 -0.8
Commuting to job workplace: Cycle 0.8 1.0 2.2 0.7 1.0 -1.5 -0.1 -1.1
Myopia 1.5 2.2 7.2 0.6 1.8 -0.0 -0.5 -2.7
Vascular/heart problems diagnosed by doctor 0.0 0.1 0.2 -0.4 0.3 -0.4 -0.5 0.0
Cholesterol lowering medication 1.1 1.6 4.4 2.1 0.5 -1.6 -0.4 -0.9
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 0.8 0.1 -0.9 0.6 0.2 -0.3
Pain experienced in last month 0.6 1.0 3.1 0.6 -0.1 0.5 1.2 -1.8
Supplements: Calcium 1.6 1.8 3.3 -1.8 -1.8 0.1 -1.5 0.7
Basal cell carcinoma (self-reported) 0.1 0.1 0.3 -0.1 -0.4 -0.4 -0.6 0.0
Heart attack/myocardial infarction (self-reported) 0.5 0.6 2.3 -0.3 -0.7 0.3 0.5 1.5
Deep venous thrombosis (DVT) (self-reported) 0.9 1.2 5.1 -0.5 -0.2 0.2 0.6 -2.3
Heart disease (siblings) 0.9 1.1 2.9 0.6 -0.4 1.1 0.9 1.7
Alcohol drinker status: Previous 1.7 1.9 4.1 1.3 0.7 2.0 1.7 -0.6
Pack years of smoking 1.5 2.2 5.0 1.6 0.6 1.3 2.2 -1.2
Impedance of whole body 0.2 1.2 2.6 -1.6 -1.2 -0.6 -1.1 -0.4
Leg fat mass (left) 0.4 1.7 3.8 1.8 0.8 0.9 2.0 -0.2
Arm predicted mass (left) 0.1 0.7 1.7 0.8 -0.3 -1.3 -0.6 0.7