Hub : Genes

ADRA1D

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1800	0.0370	1.4e-09	0.108	0.072	0.151	0.126	0.127	4.9e-13	4.2e-09	5.4e-18	4.9e-15	3.4e-15
2	ROSMAP	Brain Pre-frontal Cortex	0.2169	0.0381	1.5e-10	0.128	0.094	0.114	0.125	0.146	3.6e-16	3.8e-12	1.8e-14	8.7e-16	2.5e-18
3	TCGA	Breast Invasive Carcinoma	0.0373	0.0178	2.0e-03	0.000	0.011	0.007	NA	0.003	3.9e-01	1.9e-03	1.0e-02	NA	8.1e-02
4	TCGA	Pancreatic Adenocarcinoma	0.1330	0.0670	9.4e-03	0.007	0.023	0.005	NA	0.008	1.6e-01	3.7e-02	2.0e-01	NA	1.4e-01
5	TCGA	Stomach Adenocarcinoma	0.1180	0.0510	1.2e-03	-0.001	0.035	0.020	NA	0.015	3.6e-01	1.3e-03	1.3e-02	NA	2.8e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.2	0.3	0.9	0.7	1.0	0.1	-0.2	0.4
Bipolar Disorder or Schizophrenia	0.5	1.2	3.5	1.1	1.9	0.6	1.0	-0.2
Depressed Affect (Nagel 2018)	0.2	0.4	1.5	0.5	1.2	-0.1	-0.2	-0.7
Depression (Nagel 2018)	1.0	1.6	3.3	0.8	1.8	0.8	1.8	-0.4
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.1	0.5	-0.1	-1.0	-0.3	0.6
Neuroticism (Nagel 2018)	0.2	0.4	1.0	0.1	0.7	0.6	0.3	-1.0
Schizophrenia (2018)	0.6	1.2	2.4	0.8	1.5	0.7	1.4	-0.5
Schizophrenia vs Biploar Disorder	0.9	1.2	4.9	0.2	0.2	-0.7	-0.5	-2.2
Worry (Nagel 2018)	0.2	0.5	1.0	-0.9	-0.5	0.3	0.5	-1.0
Alzheimer’s Disease (in mother)	0.3	0.4	1.0	-0.3	0.4	0.7	0.4	1.0
Alzheimer’s Disease (in father)	1.0	1.1	3.4	-1.1	-0.1	-0.7	-0.4	-1.9
Alzheimer’s Disease (including proxy)	0.3	0.4	0.9	-0.7	0.8	-0.2	-0.3	-0.9
Crohns Disease (2017)	1.0	2.2	5.7	-0.1	-0.8	-2.4	-1.9	1.1
Irritable Bowel Disease (IBD)	0.2	0.5	1.5	0.1	-0.6	-0.8	-0.5	1.2
Ulcerative Colitis (UC)	0.1	0.2	0.4	0.2	0.1	0.7	0.6	0.4
Major Depression (MDD)	1.2	1.4	2.2	1.1	1.0	1.3	1.5	-1.0
Reaction Time	0.7	1.4	2.8	1.7	1.1	0.5	1.1	1.1
Verbal and Numeric Reasoning (VNR)	0.5	1.3	2.7	1.6	0.6	-1.6	-0.9	-0.2
Breast Cancer	0.2	0.6	1.5	0.5	0.0	-0.7	-0.7	1.2
Ovarian Cancer	0.9	1.2	4.8	-0.1	0.6	-0.7	-0.5	-2.2
Prostate Cancer	1.2	1.7	7.1	0.6	0.6	0.4	0.6	-2.7
Age at First Birth	0.8	1.1	2.6	1.6	1.2	0.4	0.8	-0.8
Bipolar Disorder (2011)	0.9	0.9	1.8	0.6	1.3	0.9	1.0	0.6
Body Mass Index (BMI) (2010)	0.4	0.5	1.0	-1.0	0.2	0.9	0.4	0.8
Coronary Artery Disease (CAD)	1.4	1.6	4.5	0.6	0.7	1.6	2.1	-0.4
Crohns Disease (2012)	1.1	1.8	5.1	0.9	1.1	-2.3	-1.1	0.9
Mean Putamen Volume	1.0	1.2	3.2	-1.2	-1.8	0.6	-0.4	0.9
Fasting Glucose	0.3	0.3	1.1	-0.1	-0.2	1.1	0.6	0.1
HbA1C	0.6	0.7	1.5	-0.6	-1.2	-0.4	-0.1	1.2
HDL Cholesterol	1.9	3.1	7.1	-0.4	-0.1	-2.7	-1.6	-2.4
LDL Cholesterol	0.5	0.8	1.6	-0.3	-0.8	1.3	1.1	0.6
Lupus	0.2	0.4	0.7	0.9	0.1	-0.6	-0.4	0.7
Neuroticism (2016)	0.8	1.2	3.4	0.6	1.0	1.8	1.2	0.1
Primary Biliary Cirrhosis	0.9	1.3	2.1	1.4	1.2	0.6	1.0	-1.4
Rheumatoid Arthritis	0.3	0.5	0.9	-0.6	-0.7	0.5	0.6	0.9
Schizophrenia (2014)	0.8	1.7	3.9	0.9	2.0	0.2	1.2	-1.5
Triglycerides	0.3	0.6	1.4	0.3	0.4	1.2	0.7	0.8
Type 2 Diabetes (T2D) (2012)	2.1	2.4	9.3	0.3	-1.3	0.1	1.0	3.0
Ulcerative Colitis	0.4	0.6	1.9	-0.5	0.4	0.7	1.4	0.4
Blood Eosinophil Count	0.2	1.7	7.2	0.5	-0.3	-0.9	-0.7	2.7
Blood Platelet Count	0.9	10.7	19.0	1.7	2.3	4.4	4.4	2.7
Blood Red Count	0.0	0.2	0.4	-0.2	-0.5	-0.2	-0.5	-0.7
Blood White Count	1.8	13.1	29.9	3.5	3.1	3.6	5.5	-0.7
Heel T-Score	0.4	3.5	6.2	-2.3	-2.5	1.2	-2.0	0.6
BMI	1.2	7.1	11.7	3.1	2.9	2.2	3.4	-0.9
Height	0.4	8.1	25.3	-1.9	-1.5	-5.0	-3.1	-0.1
Waist Hip Ratio (WHR)	0.4	1.7	3.7	-1.0	-0.7	-1.9	-0.8	-1.6
Systolic Blood Pressure	0.4	2.2	7.7	-1.8	0.1	-0.0	-0.5	-2.8
Smoking Status	0.7	1.6	5.6	-0.9	-0.2	0.6	1.2	-2.4
Allergy or Eczema	1.1	2.9	4.9	-0.9	-1.5	-2.2	-2.1	-1.4
Cardiovascular Disease	0.3	1.1	2.1	-1.5	-1.3	0.8	-0.4	-0.9
Hypothyroidism (self reported)	1.3	2.9	4.9	2.2	1.9	1.2	2.2	-0.0
Respiratory disease	0.4	0.8	2.9	-0.1	0.0	0.2	-1.0	1.7
Type 2 Diabetes (T2D) (2018)	0.9	1.7	2.7	1.6	1.1	-0.3	1.3	-1.6
Lung FEV1/FVC ratio	0.1	0.5	0.9	0.1	0.9	-0.7	-0.4	0.9
Lung FVC	0.1	0.7	1.5	1.1	0.0	-0.8	-1.2	0.0
Neuroticism	0.3	0.7	1.2	-0.2	0.6	1.1	0.8	-1.1
Chronotype (morning person)	1.9	4.5	12.2	-2.3	-3.5	-0.5	-2.0	1.1
Hair Pigment	0.0	0.6	0.9	1.0	0.9	0.3	0.7	-0.8
Tanning	0.2	2.4	6.7	-2.2	-2.6	0.4	0.4	0.6
Hand grip strength (left)	0.5	1.2	3.3	1.1	1.1	-1.8	-0.6	-0.3
Number of treatments/medications taken	1.0	1.8	5.6	0.3	-0.4	1.4	1.2	2.4
Average weekly spirits intake	0.5	0.6	1.4	-0.0	-0.1	-1.0	-0.8	-1.2
Sensitivity / hurt feelings	0.2	0.3	0.7	-0.4	-0.8	0.5	-0.4	-0.4
Frequency of depressed mood in last 2 weeks	0.7	1.0	3.1	-0.1	0.4	1.4	1.8	-0.0
Hearing difficulty/problems: Yes	0.7	1.1	2.8	1.0	0.7	-1.7	-0.6	0.9
Relative age of first facial hair	0.2	0.5	1.1	0.8	0.4	-1.1	-0.4	-0.4
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	4.6	-0.4	-0.2	-0.5	-0.1	2.1
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.9	-0.3	-0.7	1.1	-0.2	1.4
Ever had hysterectomy (womb removed)	1.5	1.6	3.0	-1.7	-1.2	-0.9	-1.7	-0.3
Systolic blood pressure, automated reading	0.5	1.5	2.2	0.8	1.5	1.2	1.1	-1.4
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	6.3	-0.6	-0.5	2.5	1.3	-0.9
Angina	0.9	1.2	2.1	-1.3	-1.5	-0.8	-0.9	-0.8
Medication for hormone replacement therapy	0.6	0.7	1.2	-1.0	-0.3	1.1	0.2	1.0
Vitamin and mineral supplements	0.3	0.4	1.2	0.6	0.4	1.1	0.4	0.1
Supplements: Zinc	1.1	1.2	2.0	-1.1	-1.2	1.3	0.2	1.4
Medication: Co-codamol	0.5	0.6	0.9	-0.2	-0.9	0.9	0.9	-0.7
Medication: Metformin	1.4	2.0	3.6	1.4	1.5	1.4	1.9	-0.4
Diabetes (father)	0.4	0.5	1.3	0.5	1.1	0.8	0.6	-0.3
Diabetes (mother)	0.8	1.1	2.2	1.5	0.9	0.6	0.7	-1.1
Severe depression (siblings)	1.6	1.8	4.0	1.5	2.0	-0.0	0.9	1.4
Pack years adult smoking proportion	1.0	1.5	3.5	1.2	0.2	0.9	1.9	-1.3
Impedance of leg (right)	0.5	2.2	5.8	-2.4	-2.1	-0.0	-0.8	0.1
Leg fat-free mass (left)	0.2	1.0	2.3	1.5	0.5	-1.5	-0.2	-0.2
Trunk fat percentage	0.6	2.4	6.2	1.8	0.9	1.3	2.5	-0.4
Hand grip strength (right)	0.6	1.6	5.2	0.8	-0.1	-2.3	-1.3	0.6
Townsend deprivation index at recruitment	0.7	1.0	2.4	1.5	0.5	1.0	0.8	-0.8
Current tobacco smoking	0.8	1.4	2.7	1.3	1.3	-0.1	0.9	-1.7
Average weekly fortified wine intake	0.2	0.2	0.6	-0.3	-0.2	-0.8	-0.5	-0.0
Maternal smoking around birth	0.3	0.4	0.8	-0.1	-0.7	-0.9	-0.3	0.8
Fed-up feelings	0.6	1.0	4.1	0.9	2.0	0.2	0.1	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.7	5.2	1.1	1.7	2.0	2.3	0.6
Relative age voice broke	0.2	0.3	0.9	-0.4	-0.1	0.3	1.0	-0.4
Taking other prescription medications	0.3	0.4	0.9	0.9	0.3	0.4	0.7	0.8
Age when periods started (menarche)	0.5	1.3	2.7	1.2	1.6	-0.0	0.1	1.5
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	2.9	-1.0	-0.2	1.7	1.0	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.5	-1.6	-1.1	0.6	-1.1	-1.2
Tinnitus: Yes, but not now, but have in the past	2.0	2.1	5.2	0.0	0.2	1.9	1.4	2.3
Qualifications: CSEs or equivalent	0.5	0.7	1.3	-0.6	-0.4	-0.7	-1.1	1.1
Serious illness, injury or assault to yourself	1.1	1.3	5.6	0.4	-0.4	-0.8	-0.3	2.4
High blood pressure	0.1	0.3	0.6	-0.4	-0.8	0.7	0.3	-0.1
Hayfever, allergic rhinitis or eczema	2.0	4.4	6.1	-1.7	-1.5	-2.3	-2.3	-2.5
Multivitamins +/- minerals	0.1	0.1	0.3	0.1	0.3	0.0	0.6	-0.5
Stomach or abdominal pain in last month	0.1	0.1	0.4	-0.4	-0.3	0.0	-0.0	0.7
Supplements: Glucosamine	0.7	1.0	2.0	1.3	0.1	1.4	1.1	-0.1
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	2.1	0.8	0.7	-1.4	-1.5	-0.4
Medication: Atenolol	1.6	2.0	7.0	1.1	1.1	-0.6	-0.5	-2.6
Medication: Levothyroxine sodium	0.2	0.3	0.9	1.0	-0.1	0.6	0.5	0.4
Sitting height	0.7	4.9	8.5	-1.6	-2.3	-2.9	-2.9	-0.0
Chronic bronchitis/emphysema (father)	0.2	0.2	0.6	0.0	0.6	0.8	-0.1	0.2
High blood pressure (mother)	1.0	1.4	2.5	-0.2	-1.2	-0.9	-1.5	-1.6
Body mass index (BMI)	0.9	3.9	6.4	2.5	1.9	1.8	2.5	-0.6
Impedance of leg (left)	0.6	3.0	7.6	-2.8	-2.3	-0.5	-1.4	0.3
Leg predicted mass (left)	0.2	1.0	2.3	1.5	0.4	-1.5	-0.2	-0.2
Trunk fat mass	0.4	1.7	3.9	1.9	0.8	0.5	2.0	-0.3
Waist circumference	0.9	3.2	5.6	2.4	2.1	0.7	2.1	-1.0
Number of incorrect matches in round	0.9	1.5	3.2	-1.4	-0.9	1.8	0.8	1.0
Past tobacco smoking	0.7	1.2	4.3	-0.5	-0.5	-0.6	-1.0	2.1
Alcohol usually taken with meals	0.8	1.3	5.6	-0.2	-0.5	-0.7	-0.6	2.4
Nervous feelings	0.6	1.0	1.6	-1.1	-1.1	1.3	0.5	-0.9
Frequency of tenseness / restlessness in last 2 weeks	1.9	2.9	5.9	1.3	2.4	1.4	1.9	-1.1
Hearing difficulty/problems with background noise	0.7	1.1	2.5	1.3	1.1	-0.6	0.1	-1.6
Hair/balding pattern: Pattern 2	0.1	0.2	0.7	-0.1	-0.8	-0.2	0.1	0.1
Had menopause	1.2	1.6	2.3	1.5	1.2	1.4	1.4	-0.0
Had other major operations	0.8	1.0	3.5	-1.9	-0.9	-0.2	-0.6	-0.7
Forced vital capacity (FVC)	0.7	2.6	7.0	-0.9	-0.9	-1.9	-2.6	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	2.4	-1.6	-1.3	0.2	-1.3	-0.8
Ever unenthusiastic/disinterested for a whole week	2.5	3.0	6.8	1.7	2.1	0.3	2.6	-1.0
Qualifications: None of the above	0.9	2.0	9.0	0.2	0.4	0.7	0.5	-3.0
Financial difficulties in last 2 years	0.7	1.0	2.2	0.1	1.1	1.1	1.5	0.5
Mouth/teeth dental problems	0.1	0.1	0.5	0.0	-0.1	-0.1	-0.3	0.7
Heart attack	0.4	0.5	1.9	-0.1	-0.7	0.3	0.3	1.4
Allergy	1.5	3.3	4.1	2.0	1.6	1.4	2.0	2.0
Pain all over the body in last month	2.4	2.6	4.6	-1.4	-2.1	1.5	-0.3	2.0
Diabetes (self-reported)	1.2	1.9	3.0	1.5	1.5	0.4	1.7	-1.3
Hayfever/allergic rhinitis (self-reported)	3.0	3.9	7.8	0.6	1.8	-2.8	-1.2	-2.6
Medication: Ramipril	0.2	0.3	0.9	0.4	-0.1	-0.1	-0.9	0.4
Medication: Simvastatin	0.2	0.4	1.0	0.4	-1.0	-0.5	-0.2	0.5
Fluid intelligence score	0.7	1.5	2.8	1.2	1.6	-1.7	-0.0	-0.7
Illnesses of siblings	1.8	2.6	6.9	0.2	1.7	-1.4	-1.0	-2.6
Neuroticism score	0.2	0.3	0.8	-0.6	0.4	0.6	0.1	-0.9
Weight	0.3	1.2	4.2	2.0	1.0	-0.5	0.9	-0.3
Impedance of arm (right)	0.1	0.3	1.3	0.2	0.4	-0.4	-0.0	-1.1
Arm fat percentage (right)	1.6	6.2	11.7	3.0	2.3	1.9	3.4	-1.3
Trunk fat-free mass	0.3	1.5	5.3	0.8	-0.2	-2.3	-1.1	0.5
Hip circumference	0.6	2.8	7.2	2.7	1.8	0.3	1.8	-0.2
Time employed in main current job	2.0	2.3	5.8	-1.2	-2.0	-0.0	0.1	2.4
Alcohol intake versus 10 years previously	0.6	0.9	3.0	1.7	0.7	-0.1	-0.6	-0.6
Father’s age at death	0.6	0.8	2.5	1.6	0.7	-0.9	0.1	0.5
Worrier / anxious feelings	0.2	0.3	1.0	-1.0	-0.5	0.4	-0.2	-0.0
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	4.3	0.6	1.3	2.0	2.1	0.0
Falls in the last year	0.3	0.4	1.1	-0.3	0.7	-1.1	0.2	-0.2
Hair/balding pattern: Pattern 3	0.2	0.2	0.7	-0.8	-0.4	0.5	-0.2	-0.1
Number of live births	1.3	1.9	4.5	0.4	0.5	-1.6	-2.1	-1.3
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	6.2	-0.9	-0.7	-1.8	-2.5	1.0
Pulse rate	0.7	1.1	4.0	-2.0	-1.0	0.8	0.0	-0.1
Happiness	1.6	2.0	4.7	0.6	1.6	0.9	2.2	-1.2
Noisy workplace	0.8	0.9	2.5	-0.3	-1.4	0.2	-0.2	1.6
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.8	-0.1	-0.6	-1.2	-0.8	1.3
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	3.4	1.1	0.7	-1.8	-0.8	-0.9
Mouth/teeth dental problems: Dentures	0.4	0.6	1.7	0.5	1.3	0.3	0.7	-0.7
Asthma	0.1	0.2	0.4	-0.6	0.1	0.6	-0.6	0.2
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.2	5.9	-1.4	-1.1	-1.3	-2.4	0.1
Medication: Cholesterol lowering	0.7	1.1	3.5	-0.0	-0.8	1.1	0.4	1.9
Depression (self-reported)	0.1	0.2	0.4	-0.3	-0.1	0.7	0.3	-0.5
Medication: Lansoprazole	2.4	2.7	9.0	2.0	3.0	-0.2	0.3	-0.5
Prospective memory result	0.6	0.7	1.5	-1.2	-0.4	0.7	1.2	-0.0
Lung cancer (father)	0.1	0.1	0.3	0.5	0.3	0.3	-0.0	-0.5
Illnesses of mother	0.2	0.3	0.6	-0.5	-0.2	0.7	0.3	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	4.4	-0.5	-0.6	-1.6	-2.1	1.0
Pulse wave Arterial Stiffness index	1.2	1.4	5.7	0.4	0.2	-0.2	-1.0	-2.4
Impedance of arm (left)	0.1	0.4	1.0	-0.4	-0.2	-0.8	-0.5	-1.0
Arm fat mass (right)	0.8	3.4	7.5	2.7	1.7	0.9	2.2	-0.8
Trunk predicted mass	0.3	1.5	5.5	0.8	-0.3	-2.4	-1.1	0.5
Standing height	0.8	7.5	22.6	-0.8	-1.7	-4.8	-3.3	0.5
Length of working week for main job	1.2	1.3	5.7	-0.9	-0.5	0.1	-0.0	2.4
Exposure to tobacco smoke at home	0.3	0.3	1.0	-1.0	0.1	-0.1	-0.1	-0.8
Breastfed as a baby	0.2	0.2	0.5	0.2	0.7	-0.7	-0.3	0.1
Tense / ‘highly strung’	1.1	1.8	2.4	-1.3	-1.0	1.5	1.2	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.0	-0.9	-0.2	0.4	0.3	-1.0
Hair/balding pattern: Pattern 4	1.7	4.1	12.9	-1.4	-0.6	-1.1	-2.1	3.6
Birth weight of first child	0.2	0.4	1.4	-0.0	-0.0	-0.8	-1.2	0.0
Peak expiratory flow (PEF)	0.4	0.9	1.5	-1.2	-1.1	-0.0	-0.6	1.2
Pulse wave reflection index	1.2	1.5	4.5	-0.3	-1.0	-0.1	-1.4	-2.1
Ever highly irritable/argumentative for 2 days	2.1	2.5	4.3	1.6	1.4	0.7	2.1	-1.8
Loud music exposure frequency	0.4	0.4	0.7	0.8	0.5	0.5	0.9	0.3
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.3	0.4	0.2	-1.2	-0.9	0.7
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.7	0.1	0.1	0.7	0.9	-0.2
Blood clot in the leg (DVT)	0.7	0.9	3.7	-0.5	-0.5	0.2	0.5	-1.9
Medication: Paracetamol	0.8	1.4	4.0	0.8	0.8	0.7	2.0	1.1
Headache pain in last month	1.3	2.3	6.4	0.5	-0.4	-2.0	-2.5	0.8
Medication for cholesterol, blood pressure or diabetes	1.5	2.5	4.3	1.5	2.0	-1.2	-0.8	-2.1
Glaucoma (self-reported)	0.1	0.1	0.4	0.2	0.6	0.1	-0.1	0.4
Gout (self-reported)	0.9	1.2	2.6	1.1	1.4	1.6	0.4	0.5
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	1.8	1.3	0.6	0.8	1.3	1.1
Medication: Amlodipine	1.9	2.7	5.5	-1.3	-0.3	2.4	1.8	-1.7
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.9	0.8	0.9	0.1	0.2	0.7
Birth weight	0.3	0.8	1.8	1.0	0.7	-0.6	-0.2	1.4
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.7	-1.3	-0.6	-0.9	-1.0	0.2
High blood pressure (siblings)	0.7	0.9	2.7	-0.2	-1.2	0.7	0.1	1.6
Forced vital capacity (FVC), Best measure	0.8	2.8	6.9	-0.8	-1.1	-2.1	-2.6	0.9
Body fat percentage	0.9	3.5	8.6	2.0	1.3	1.7	2.9	-0.7
Leg fat percentage (right)	1.0	3.5	7.6	2.2	1.2	1.8	2.8	-0.5
Arm fat-free mass (right)	0.3	1.5	5.2	0.5	-0.5	-2.3	-1.2	0.5
Exposure to tobacco smoke outside home	1.0	1.3	6.1	-0.1	0.0	-0.4	-0.6	-2.5
Comparative body size at age 10	0.4	1.2	2.8	1.7	0.2	-1.5	-0.8	0.3
Number of full brothers	0.7	0.8	2.6	-0.9	-1.6	0.4	0.0	-0.7
Worry too long after embarrassment	0.8	1.3	4.4	-0.4	-0.3	-0.9	-1.1	-2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.7	-0.3	0.7	0.8	1.6	-0.5
Wheeze or whistling in the chest in last year	1.9	3.4	7.6	2.7	2.8	-1.2	0.3	-0.7
Number of children fathered	1.5	1.7	4.9	0.6	-0.4	1.3	1.0	2.2
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.7	-0.4	0.0	0.8	0.8	0.2
Age at first live birth	0.3	0.6	1.3	1.0	1.2	-0.2	0.7	-0.2
Pulse wave peak to peak time	1.2	1.4	6.2	-0.4	-0.2	-0.1	0.9	2.5
Health satisfaction	0.1	0.1	0.2	-0.3	-0.3	0.3	0.4	-0.1
Shortness of breath walking on level ground	1.6	2.0	5.5	-0.6	0.0	1.7	1.1	2.3
Qualifications: College or University degree	0.2	0.7	2.6	-0.3	-0.6	-0.2	0.8	1.6
Eye problems/disorders: None of the above	0.5	0.6	1.3	-0.3	0.4	-1.1	-0.9	-0.9
Mouth/teeth dental problems: Loose teeth	1.3	1.5	4.3	-0.6	-0.7	1.4	0.7	2.1
Emphysema/chronic bronchitis	0.0	0.0	0.1	0.0	0.1	0.1	0.2	-0.1
Medication for pain relief, constipation, heartburn	1.0	1.7	4.0	0.8	1.9	-0.6	-0.4	-2.0
Neck or shoulder pain in last month	0.7	1.0	1.8	-1.2	-0.6	1.0	0.5	1.3
Medication: Blood pressure	1.6	2.8	4.8	-2.2	-2.1	1.6	0.7	1.3
Angina (self-reported)	0.9	1.2	2.5	-1.4	-1.6	-0.7	-0.8	-0.6
Migraine (self-reported)	1.4	1.7	3.7	0.9	0.2	1.8	0.9	1.9
Medication: Ibuprofen	1.5	1.8	3.8	-1.7	-1.1	-0.5	-2.0	1.1
Medication: Allopurinol	0.4	0.6	1.1	0.8	1.0	1.1	0.3	0.3
Medication: Omeprazole	0.9	1.1	2.6	-0.7	-1.6	1.4	0.5	0.4
Medication: Seretide 50 evohaler	0.4	0.5	0.8	0.1	0.9	0.4	-0.8	-0.8
Mean time to correctly identify matches	0.7	1.4	4.5	2.1	1.2	0.4	0.9	0.4
Heart disease (mother)	0.1	0.1	0.3	-0.2	-0.1	0.4	0.5	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.7	-0.8	-0.5	-0.1	-0.2	-0.1
Whole body fat mass	0.5	2.0	4.9	1.9	0.9	1.0	2.2	-0.2
Leg fat mass (right)	0.5	2.0	4.2	1.9	0.9	1.0	2.1	-0.5
Arm predicted mass (right)	0.3	1.3	4.1	0.4	-0.7	-2.0	-1.1	0.7
Pulse rate, automated reading	0.3	1.0	1.8	-1.1	0.4	1.2	1.3	-0.3
Alcohol intake frequency.	0.8	1.8	3.7	1.9	1.5	0.7	1.4	0.5
Comparative height size at age 10	0.7	3.7	11.7	0.4	-0.7	-3.4	-2.3	-0.9
Number of full sisters	0.2	0.3	0.7	-0.4	-0.6	-0.4	-0.8	0.3
Suffer from ‘nerves’	0.3	0.4	1.4	-0.4	0.7	0.0	-0.2	-1.2
Overall health rating	0.2	0.4	0.8	-0.9	-0.6	0.9	0.3	0.2
Chest pain or discomfort	1.0	1.4	3.3	0.2	0.4	1.0	1.6	1.8
Had major operations	2.4	2.8	6.3	-2.0	-2.5	0.5	-1.0	1.6
Age at last live birth	1.1	1.6	4.3	2.1	1.6	-0.9	0.4	-0.4
Family relationship satisfaction	1.0	1.3	2.3	-0.7	1.1	0.8	1.5	-1.3
Leg pain on walking	0.5	0.7	2.2	0.2	-0.4	0.3	1.5	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.7	-1.3	-1.1	1.0	0.3	0.4
Commuting to job workplace: Car/motor vehicle	1.8	2.1	3.8	-1.9	-1.8	-0.7	-1.6	0.5
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	1.1	-0.1	-0.4	-0.4	-1.1	0.1
Medication: Aspirin	2.2	2.9	7.4	-1.4	-2.7	0.4	1.0	2.0
Supplements: Vitamin C	0.3	0.4	0.7	-0.5	-0.8	-0.6	-0.1	0.8
Knee pain experienced in last month	0.7	1.1	2.7	0.3	1.6	1.5	0.6	-0.0
Hypertension (Self-reported)	0.1	0.3	0.7	-0.5	-0.8	0.4	-0.1	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.7	3.2	7.1	-1.2	-2.3	1.4	-0.2	2.7
Illnesses of father: Heart disease	0.1	0.1	0.2	0.0	-0.4	0.4	0.3	-0.1
Illnesses of siblings: Diabetes	0.2	0.2	0.4	-0.3	-0.3	0.7	0.6	0.6
Smoking status: Previous	0.6	0.9	1.8	-1.1	-0.6	0.7	0.6	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	1.4	3.0	5.8	-0.9	-1.4	-2.4	-2.4	-0.8
Whole body fat-free mass	0.2	1.3	4.7	1.1	0.0	-2.2	-0.8	0.4
Leg fat-free mass (right)	0.2	1.2	3.6	1.3	0.5	-1.9	-0.6	-0.2
Arm fat percentage (left)	1.3	5.2	9.8	2.8	2.1	1.6	3.1	-1.3
Average weekly red wine intake	2.4	3.6	6.8	1.2	1.1	2.6	2.4	1.7
Handedness (chirality/laterality): Left-handed	2.3	2.7	6.5	1.7	1.5	-1.3	0.4	-2.5
Mood swings	0.3	0.5	1.2	0.6	0.2	1.0	1.1	0.2
Loneliness, isolation	0.3	0.5	1.2	-0.2	1.1	0.2	0.2	-1.0
Long-standing illness, disability or infirmity	1.3	2.0	3.2	-0.7	0.2	1.8	1.7	1.8
Ever had bowel cancer screening	0.5	0.6	2.3	-0.2	-1.5	-0.2	-0.7	0.1
Diabetes diagnosed by doctor	1.8	2.9	4.4	2.0	2.1	-0.2	1.6	-1.9
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	4.0	-0.1	-0.1	-1.3	-1.5	-2.0
Friendships satisfaction	0.9	1.1	1.8	0.1	0.6	1.3	1.2	-1.3
Qualifications: nursing, teaching	0.4	0.5	1.1	1.0	-0.2	-1.1	-0.7	0.2
Commuting to job workplace: Walk	1.0	1.1	2.7	0.2	0.2	1.6	1.5	0.7
Eye problems/disorders: Cataract	1.0	1.1	2.1	0.2	-0.7	1.4	1.1	1.4
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	2.5	-1.2	-1.6	-1.2	-1.5	-1.1
Medication for cholesterol	0.1	0.2	0.4	-0.0	0.5	0.6	0.6	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	3.5	-1.9	-1.3	0.9	-0.3	1.4
Back pain experienced in last month	0.7	1.0	4.0	-0.9	0.1	-0.5	-0.1	2.0
Mineral and other dietary supplements	1.3	1.7	3.3	1.2	1.8	-0.8	-0.5	-1.7
Breast cancer (self-reported)	0.6	0.7	1.2	0.9	1.1	0.3	0.8	0.8
Asthma (self-reported)	0.1	0.3	0.8	-0.3	0.2	0.3	-0.9	0.6
Osteoporosis (self-reported)	0.1	0.1	0.3	0.6	0.4	0.3	0.0	0.2
Osteoarthritis (self-reported)	0.6	0.8	2.6	-0.7	0.3	1.6	0.7	0.7
Medication: Aspirin	1.8	2.3	6.7	-1.3	-2.6	0.2	0.8	1.6
Medication: Gliclazide	0.5	0.5	1.1	-1.0	-0.8	-0.5	-0.3	-0.9
Illnesses of father: None of the above (group 1)	0.7	0.9	1.6	1.0	1.2	-0.6	1.0	-0.6
Smoking status: Current	0.7	1.1	2.1	1.2	1.1	-0.1	0.7	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.6	-1.1	-1.3	0.6	-0.4	0.8
Whole body water mass	0.2	1.3	4.5	1.0	-0.0	-2.1	-0.8	0.3
Leg predicted mass (right)	0.2	1.2	3.7	1.3	0.4	-1.9	-0.6	-0.1
Arm fat mass (left)	0.7	2.8	5.6	2.4	1.4	0.9	2.2	-0.9
Number of self-reported non-cancer illnesses	0.4	0.8	1.3	-0.5	-1.2	-0.2	-1.0	1.1
Average weekly champagne plus white wine intake	0.3	0.5	1.2	0.6	1.1	0.2	0.9	-0.0
Miserableness	0.6	1.0	3.0	1.2	1.7	-0.5	-0.1	-0.6
Guilty feelings	1.3	1.9	4.0	-2.0	-1.9	0.5	-0.9	1.0
Wears glasses or contact lenses	0.5	0.5	1.7	1.3	0.6	0.4	0.6	0.1
Ever taken oral contraceptive pill	1.3	1.4	3.9	-1.2	-0.1	0.8	1.1	-2.0
Hearing aid user	1.0	1.2	2.0	1.1	1.3	0.9	1.4	-0.1
Mother’s age at death	0.5	0.6	1.4	0.5	0.8	0.5	1.2	-0.7
Financial situation satisfaction	0.5	0.6	1.1	-1.1	-0.2	0.8	0.8	-0.6
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.6	0.1	0.3	-0.8	-0.1	-0.1
Commuting to job workplace: Public transport	2.0	2.4	4.5	1.9	1.9	0.4	2.1	0.4
Eye problems/disorders: Glaucoma	0.8	1.0	1.5	-1.2	-1.1	-0.8	-1.1	-0.5
Medication: Blood pressure	0.1	0.1	0.5	0.2	-0.7	-0.1	-0.4	0.1
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.1	0.3	0.9	-0.1	0.1	-1.1
Supplements: Fish oil (including cod liver oil)	1.0	1.3	3.1	-1.1	-1.7	0.4	0.0	1.4
High cholesterol (Self-reported)	0.2	0.4	1.0	1.0	0.2	0.1	-0.3	0.9
Medication: Bendroflumethiazide	0.1	0.2	0.4	0.6	0.1	0.4	-0.3	-0.4
Medication: Paracetamol	1.4	2.1	3.4	1.3	1.9	1.0	1.8	1.1
Medication: Lisinopril	1.3	1.7	4.7	-0.9	-1.3	0.8	0.8	2.2
Medication: Atorvastatin	0.9	1.1	2.7	1.0	1.7	0.7	0.7	-0.8
Illnesses of father: High blood pressure	2.2	2.7	7.0	-1.4	-2.6	-0.2	-2.0	0.8
Alcohol drinker status: Never	3.3	3.9	7.3	0.2	1.5	2.6	2.7	1.8
Ever smoked	1.5	2.7	6.8	1.8	1.7	0.1	0.6	-2.6
Basal metabolic rate	0.2	0.9	2.9	1.1	0.1	-1.7	-0.5	0.1
Leg fat percentage (left)	0.8	2.8	6.2	1.9	1.0	1.7	2.5	-0.3
Arm fat-free mass (left)	0.2	0.8	2.4	0.9	-0.3	-1.6	-0.7	0.5
Number of operations (self-reported)	1.3	1.9	3.6	-1.9	-1.8	-0.4	-1.6	-0.3
Average weekly beer plus cider intake	1.6	2.4	6.5	1.9	2.6	-0.2	0.7	-1.0
Irritability	1.1	1.9	3.7	0.5	1.9	1.7	1.6	0.0
Risk taking	0.4	0.6	1.3	-0.2	-1.1	-1.1	-0.6	-0.3
Ever had prostate specific antigen (PSA) test	0.5	0.6	2.1	0.3	-0.0	-1.4	-0.7	0.5
Fractured/broken bones in last 5 years	1.1	1.4	3.0	0.9	1.0	-1.4	-0.0	-1.7
Age started oral contraceptive pill	1.1	1.4	5.8	2.4	0.8	-0.7	-0.2	0.1
Diastolic blood pressure, automated reading	0.2	0.6	1.8	-0.3	-0.2	1.3	0.6	-0.8
Ever depressed for a whole week	0.7	0.9	3.6	0.4	0.6	-0.1	1.9	-0.6
Unable to work because of sickness or disability	0.6	0.7	1.6	-1.3	-0.6	0.9	0.7	-0.8
Commuting to job workplace: Cycle	0.8	1.0	2.2	0.7	1.0	-1.5	-0.1	-1.1
Myopia	1.5	2.2	7.2	0.6	1.8	-0.0	-0.5	-2.7
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.2	-0.4	0.3	-0.4	-0.5	0.0
Cholesterol lowering medication	1.1	1.6	4.4	2.1	0.5	-1.6	-0.4	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.8	0.1	-0.9	0.6	0.2	-0.3
Pain experienced in last month	0.6	1.0	3.1	0.6	-0.1	0.5	1.2	-1.8
Supplements: Calcium	1.6	1.8	3.3	-1.8	-1.8	0.1	-1.5	0.7
Basal cell carcinoma (self-reported)	0.1	0.1	0.3	-0.1	-0.4	-0.4	-0.6	0.0
Heart attack/myocardial infarction (self-reported)	0.5	0.6	2.3	-0.3	-0.7	0.3	0.5	1.5
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	5.1	-0.5	-0.2	0.2	0.6	-2.3
Heart disease (siblings)	0.9	1.1	2.9	0.6	-0.4	1.1	0.9	1.7
Alcohol drinker status: Previous	1.7	1.9	4.1	1.3	0.7	2.0	1.7	-0.6
Pack years of smoking	1.5	2.2	5.0	1.6	0.6	1.3	2.2	-1.2
Impedance of whole body	0.2	1.2	2.6	-1.6	-1.2	-0.6	-1.1	-0.4
Leg fat mass (left)	0.4	1.7	3.8	1.8	0.8	0.9	2.0	-0.2
Arm predicted mass (left)	0.1	0.7	1.7	0.8	-0.3	-1.3	-0.6	0.7