Hub : Genes

SMOX

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 NTR Blood 0.0568 0.0154 1.5e-05 0.031 0.013 0.028 0.025 0.033 3.0e-10 2.7e-05 2.2e-09 1.5e-08 6.5e-11
2 YFS Blood 0.4412 0.0306 0.0e+00 0.367 0.346 0.425 0.322 0.416 2.0e-127 1.4e-118 4.0e-154 6.1e-109 8.9e-150
3 TCGA Colon Adenocarcinoma 0.1650 0.0500 3.8e-06 0.049 0.116 0.052 NA 0.081 7.9e-04 3.3e-07 5.8e-04 NA 2.0e-05
4 TCGA Head and Neck Squamous Cell Carcinoma 0.0394 0.0194 8.2e-03 -0.001 0.011 0.019 NA 0.002 3.8e-01 1.8e-02 3.0e-03 NA 1.7e-01
5 TCGA Testicular Germ Cell Tumors 0.3090 0.0880 2.8e-04 0.054 0.053 0.038 NA 0.074 5.5e-03 5.9e-03 1.7e-02 NA 1.3e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.5 0.7 1.3 1.1 1.0 1.1 -0.0 0.1
Bipolar Disorder or Schizophrenia 0.2 0.5 1.1 -0.2 -0.4 1.1 1.0 0.5
Depressed Affect (Nagel 2018) 0.8 1.7 5.4 -1.2 -1.2 -2.3 0.2 -0.3
Depression (Nagel 2018) 0.8 1.2 2.9 -1.7 -1.5 -0.0 -0.0 0.9
Intelligence (Savage-Jansen 2018) 0.1 0.2 0.3 -0.3 -0.2 -0.2 -0.6 -0.6
Neuroticism (Nagel 2018) 0.5 1.3 3.2 -1.3 -1.2 -1.8 0.1 0.3
Schizophrenia (2018) 0.5 1.0 1.7 -1.1 -1.3 0.5 1.2 0.6
Schizophrenia vs Biploar Disorder 0.9 1.2 2.4 -1.5 -1.5 0.3 -0.1 -1.2
Worry (Nagel 2018) 0.3 0.7 1.5 -1.2 -1.0 -0.6 -0.4 0.6
Alzheimer’s Disease (in mother) 0.4 0.5 1.3 0.7 0.6 1.1 -0.2 0.5
Alzheimer’s Disease (in father) 1.1 1.2 5.8 0.1 0.0 -0.5 -0.3 -2.4
Alzheimer’s Disease (including proxy) 0.9 1.3 3.1 1.2 1.3 0.1 0.3 -1.8
Crohns Disease (2017) 0.9 1.9 4.5 0.7 0.8 -1.9 2.1 0.3
Irritable Bowel Disease (IBD) 0.2 0.4 0.7 0.7 0.5 -0.3 0.8 0.6
Ulcerative Colitis (UC) 0.1 0.1 0.3 0.4 0.0 0.5 -0.4 0.4
Major Depression (MDD) 2.0 2.4 5.2 -0.2 -0.6 2.3 -1.8 1.8
Reaction Time 0.3 0.6 2.6 -0.0 -0.3 1.6 0.2 -0.6
Verbal and Numeric Reasoning (VNR) 0.1 0.3 0.7 -0.7 -0.4 0.8 0.0 -0.4
Breast Cancer 0.2 0.5 1.4 -0.3 0.0 -0.2 0.9 1.2
Ovarian Cancer 0.2 0.2 0.5 0.7 0.6 -0.0 0.5 0.2
Prostate Cancer 2.7 3.8 7.2 -2.6 -2.7 1.4 -1.7 0.0
Age at First Birth 0.9 1.3 2.1 -1.4 -1.4 1.0 -0.8 0.9
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.2 0.3 1.0 0.1 0.2 -0.5 -0.0 -1.0
Coronary Artery Disease (CAD) 0.9 1.1 1.8 -1.4 -1.1 0.7 -0.5 1.2
Crohns Disease (2012) 0.5 0.8 1.5 0.7 0.7 -0.3 1.2 1.2
Mean Putamen Volume 1.7 2.0 3.4 1.4 1.6 -0.7 1.2 1.8
Fasting Glucose 0.1 0.1 0.6 -0.0 0.1 -0.8 0.3 -0.2
HbA1C 1.0 1.1 2.1 1.1 1.4 -0.8 1.2 -0.2
HDL Cholesterol 0.8 1.4 2.5 1.2 1.1 -1.6 1.0 -0.7
LDL Cholesterol 1.1 1.7 2.7 -1.6 -1.4 0.8 -1.6 0.6
Lupus 0.1 0.1 0.3 -0.3 -0.6 0.2 0.3 0.2
Neuroticism (2016) 0.4 0.5 1.5 0.3 0.3 -1.2 0.2 -0.9
Primary Biliary Cirrhosis 1.1 1.6 2.7 -1.7 -1.4 1.3 -0.9 0.9
Rheumatoid Arthritis 0.6 0.8 3.7 -0.2 -0.4 0.5 -0.1 1.9
Schizophrenia (2014) 0.6 1.3 2.7 -1.3 -1.3 1.7 0.0 0.4
Triglycerides 1.1 1.8 4.2 -1.1 -1.2 0.2 -1.4 -2.1
Type 2 Diabetes (T2D) (2012) 1.0 1.1 2.7 0.2 0.3 -1.7 1.3 -1.1
Ulcerative Colitis 0.6 0.9 2.6 -0.3 -0.6 1.0 -1.6 0.7
Blood Eosinophil Count 0.1 0.9 2.6 0.1 0.2 0.0 -1.3 -1.6
Blood Platelet Count 0.1 1.3 2.0 -1.2 -0.9 1.4 -0.1 1.4
Blood Red Count 0.6 5.4 10.7 2.6 2.6 -0.6 3.3 1.6
Blood White Count 3.7 27.4 40.4 -6.3 -6.4 4.6 -3.2 5.0
Heel T-Score 0.1 0.6 1.4 -1.2 -0.6 0.5 1.0 0.4
BMI 0.4 2.6 9.9 -1.0 -0.9 3.2 -1.1 0.3
Height 0.8 14.5 30.9 3.8 3.5 -3.1 -2.3 -5.6
Waist Hip Ratio (WHR) 0.2 1.1 2.5 -1.4 -1.6 0.4 -0.0 1.0
Systolic Blood Pressure 1.3 6.4 15.3 2.0 2.1 -2.3 3.9 1.7
Smoking Status 0.7 1.6 5.8 -0.9 -0.9 0.9 0.2 2.4
Allergy or Eczema 1.3 3.4 6.0 1.9 1.9 -2.5 0.2 -1.9
Cardiovascular Disease 0.4 1.3 4.7 -0.2 -0.4 -0.9 2.2 1.0
Hypothyroidism (self reported) 1.7 3.8 7.6 -2.2 -2.5 0.3 0.5 2.8
Respiratory disease 1.6 3.6 5.3 1.7 1.8 -1.4 2.1 -2.3
Type 2 Diabetes (T2D) (2018) 1.0 1.9 3.3 -1.8 -1.5 1.4 -1.3 -0.0
Lung FEV1/FVC ratio 1.0 5.0 12.1 3.0 3.5 -0.8 0.9 -1.6
Lung FVC 0.3 1.4 4.0 -0.9 -1.1 0.6 0.6 2.0
Neuroticism 0.8 1.9 3.2 -1.8 -1.8 -1.7 -0.4 -0.1
Chronotype (morning person) 0.2 0.5 1.9 0.2 0.4 -0.5 0.1 -1.4
Hair Pigment 0.2 4.6 8.1 -2.1 -2.2 2.8 -2.2 0.9
Tanning 0.1 1.4 4.5 -0.6 -0.2 1.5 -2.1 0.3
Hand grip strength (left) 0.9 2.3 5.8 2.2 2.4 -0.9 0.1 -0.2
Number of treatments/medications taken 1.0 1.7 5.8 0.9 0.7 -1.0 2.4 -0.7
Average weekly spirits intake 0.2 0.3 0.5 0.5 0.7 -0.7 -0.5 -0.0
Sensitivity / hurt feelings 0.7 1.2 3.0 -0.5 -0.9 -1.2 0.7 1.7
Frequency of depressed mood in last 2 weeks 0.3 0.4 0.9 -0.8 -1.0 -0.5 0.4 0.2
Hearing difficulty/problems: Yes 0.8 1.2 2.8 1.7 1.7 -0.3 0.5 -0.2
Relative age of first facial hair 0.4 0.9 1.4 -1.1 -1.2 -1.1 -0.1 -0.9
Other serious medical condition/disability diagnosed by doctor 1.1 1.5 2.4 1.5 1.5 1.1 1.2 0.1
Ever used hormone-replacement therapy (HRT) 1.7 2.1 4.7 1.3 1.2 -1.6 2.2 -0.0
Ever had hysterectomy (womb removed) 0.6 0.7 1.8 0.5 0.2 -1.3 1.2 -0.2
Systolic blood pressure, automated reading 1.1 3.2 7.5 1.0 1.1 -0.2 2.7 2.5
Eye problems/disorders: Diabetes related eye disease 1.3 1.4 2.2 -1.4 -1.5 0.2 -1.3 1.1
Angina 0.5 0.7 1.4 -1.1 -1.2 0.5 0.8 -0.2
Medication for hormone replacement therapy 0.4 0.4 1.7 0.4 0.2 -1.3 -0.4 0.1
Vitamin and mineral supplements 1.6 2.2 6.9 -0.7 -0.6 2.6 0.4 1.7
Supplements: Zinc 1.8 1.9 4.7 2.2 1.8 -1.2 0.6 0.2
Medication: Co-codamol 0.3 0.4 0.9 -0.7 -0.9 0.5 -0.5 0.1
Medication: Metformin 1.2 1.8 3.5 -1.5 -1.2 1.9 -0.8 0.9
Diabetes (father) 1.2 1.4 3.0 -1.7 -1.7 0.7 -0.6 -0.6
Diabetes (mother) 1.2 1.5 2.7 -1.1 -1.2 1.6 -0.7 1.3
Severe depression (siblings) 1.2 1.4 2.9 1.5 1.7 -0.1 0.8 1.0
Pack years adult smoking proportion 0.4 0.6 2.3 0.0 -0.4 -0.3 0.7 1.5
Impedance of leg (right) 0.2 1.0 2.4 -1.4 -1.5 -0.6 0.1 0.6
Leg fat-free mass (left) 1.0 5.2 8.8 3.0 2.7 -0.4 -1.5 -2.7
Trunk fat percentage 0.4 1.7 5.6 -0.6 -0.8 2.4 -1.2 0.4
Hand grip strength (right) 0.7 1.9 4.0 2.0 2.0 -1.2 0.5 0.2
Townsend deprivation index at recruitment 2.1 3.0 4.2 -1.8 -2.0 1.8 -2.1 -0.7
Current tobacco smoking 1.0 1.6 2.7 -1.4 -1.6 1.5 -0.8 0.9
Average weekly fortified wine intake 1.5 1.8 3.2 -1.6 -1.1 -1.8 1.2 -0.7
Maternal smoking around birth 0.4 0.5 1.7 -0.1 -0.3 -1.3 0.9 0.2
Fed-up feelings 0.6 1.1 5.4 0.1 -0.1 -2.3 -0.0 -0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.4 3.2 -1.8 -1.7 0.2 0.4 0.9
Relative age voice broke 0.3 0.4 1.7 -0.1 -0.3 0.4 -1.3 -0.4
Taking other prescription medications 1.3 2.0 9.0 0.2 -0.0 -0.7 3.0 -0.9
Age when periods started (menarche) 0.3 0.7 1.4 0.3 0.5 -1.0 0.9 -1.2
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 2.4 0.5 0.4 -1.3 1.5 0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 1.6 -0.3 0.0 0.3 0.9 1.3
Tinnitus: Yes, but not now, but have in the past 1.8 1.9 7.4 0.6 0.7 1.0 0.3 2.7
Qualifications: CSEs or equivalent 1.1 1.5 3.2 1.8 1.5 0.6 -0.4 -1.1
Serious illness, injury or assault to yourself 4.6 5.5 7.9 2.8 2.4 -1.9 2.8 -1.7
High blood pressure 0.8 2.3 6.8 0.8 0.8 -1.2 2.6 1.4
Hayfever, allergic rhinitis or eczema 0.8 1.8 3.2 1.6 1.3 -1.8 -0.6 -1.0
Multivitamins +/- minerals 1.5 1.9 4.3 -0.8 -0.9 -1.0 -1.6 -2.1
Stomach or abdominal pain in last month 0.6 0.7 1.8 -0.3 -0.3 -0.5 -1.3 -1.2
Supplements: Glucosamine 0.5 0.6 1.0 -1.0 -0.8 0.6 -0.8 0.7
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.2 -0.0 0.5 0.3 -0.2 0.2
Medication: Atenolol 1.3 1.6 3.2 -1.8 -1.6 1.1 0.3 0.9
Medication: Levothyroxine sodium 0.6 1.0 2.2 -0.5 -0.9 -0.0 1.3 1.5
Sitting height 0.9 6.3 13.8 2.2 2.2 -1.9 -2.1 -3.7
Chronic bronchitis/emphysema (father) 0.9 1.1 5.4 0.1 0.1 0.0 2.3 0.3
High blood pressure (mother) 0.3 0.4 0.7 0.3 0.5 -0.9 0.8 -0.7
Body mass index (BMI) 0.2 1.0 4.4 -0.3 -0.2 2.1 -0.3 0.8
Impedance of leg (left) 0.2 0.8 1.7 -1.2 -1.3 -0.7 0.6 0.1
Leg predicted mass (left) 1.0 5.1 8.7 3.0 2.7 -0.4 -1.5 -2.6
Trunk fat mass 0.3 1.2 3.6 0.3 0.2 1.9 -1.4 -0.4
Waist circumference 0.3 1.2 4.3 -0.5 -0.5 2.1 -1.0 -0.2
Number of incorrect matches in round 0.9 1.5 2.7 0.9 1.0 -1.5 1.6 0.9
Past tobacco smoking 1.7 3.2 10.3 1.2 1.3 -0.7 -1.4 -3.2
Alcohol usually taken with meals 1.2 2.0 3.0 -1.7 -1.7 1.5 -1.1 0.9
Nervous feelings 0.5 0.9 1.9 -1.3 -1.4 0.6 -0.7 0.4
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 3.4 -1.7 -1.8 0.8 0.1 0.5
Hearing difficulty/problems with background noise 0.3 0.4 1.1 -0.3 -0.2 1.0 0.4 0.9
Hair/balding pattern: Pattern 2 1.0 1.2 2.8 -1.6 -1.7 -0.2 0.3 0.8
Had menopause 1.8 2.2 4.8 -1.8 -1.4 0.7 0.7 2.2
Had other major operations 0.2 0.2 0.4 0.3 0.0 -0.7 -0.6 -0.5
Forced vital capacity (FVC) 1.2 4.8 9.3 2.2 1.8 -3.1 0.7 -2.4
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.1 0.3 -0.3 -0.1 -0.3 0.6 0.1
Ever unenthusiastic/disinterested for a whole week 3.0 3.7 7.2 -1.3 -1.5 2.1 -2.7 1.6
Qualifications: None of the above 0.3 0.6 0.9 -1.0 -1.0 -0.7 0.7 0.1
Financial difficulties in last 2 years 0.3 0.5 1.5 0.1 -0.4 0.8 -1.2 -0.2
Mouth/teeth dental problems 1.2 1.9 4.5 2.1 1.6 1.0 -1.3 0.3
Heart attack 0.5 0.6 1.3 -1.1 -1.1 0.0 0.6 0.0
Allergy 1.3 2.9 4.6 -2.1 -1.8 2.1 -0.8 1.4
Pain all over the body in last month 1.7 1.9 2.1 1.5 1.4 -1.4 1.1 -1.4
Diabetes (self-reported) 1.4 2.2 3.2 -1.6 -1.5 1.8 -1.6 0.6
Hayfever/allergic rhinitis (self-reported) 1.1 1.5 3.6 1.9 1.7 -0.4 0.4 -0.7
Medication: Ramipril 0.6 0.7 2.0 -0.7 -0.2 0.9 1.4 0.6
Medication: Simvastatin 0.2 0.3 0.6 -0.8 -0.8 0.3 0.5 -0.2
Fluid intelligence score 0.2 0.3 0.6 -0.7 -0.6 0.8 -0.5 -0.1
Illnesses of siblings 0.4 0.6 0.9 0.9 0.9 -0.5 -0.4 -0.9
Neuroticism score 0.5 1.1 2.3 -1.0 -1.4 -1.5 -0.4 -0.2
Weight 0.4 2.0 3.0 1.6 1.5 0.8 -1.2 -1.7
Impedance of arm (right) 0.3 1.4 3.0 -1.1 -1.1 1.0 -1.7 -0.7
Arm fat percentage (right) 0.9 3.5 11.0 -1.3 -1.3 3.3 -1.4 1.0
Trunk fat-free mass 1.1 6.5 10.4 3.2 3.2 -1.4 -0.8 -3.1
Hip circumference 0.5 2.1 3.9 1.0 1.0 2.0 -1.6 -1.5
Time employed in main current job 0.7 0.8 1.5 0.5 0.9 1.0 0.5 1.2
Alcohol intake versus 10 years previously 0.3 0.5 1.0 -0.4 -0.3 -0.7 0.7 -1.0
Father’s age at death 1.1 1.5 4.1 0.7 0.8 2.0 -1.2 1.1
Worrier / anxious feelings 0.3 0.6 1.7 -0.5 -0.4 -0.9 -0.1 -1.3
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 0.9 -0.7 -0.9 -0.6 0.7 0.4
Falls in the last year 0.1 0.2 0.7 0.3 -0.0 -0.0 0.8 -0.3
Hair/balding pattern: Pattern 3 1.4 2.1 3.6 1.9 1.5 -0.7 1.5 1.5
Number of live births 1.3 1.8 3.0 1.1 1.3 -0.5 1.7 -1.7
Forced expiratory volume in 1-second (FEV1) 2.2 7.3 10.8 3.3 3.1 -3.1 1.1 -2.4
Pulse rate 0.2 0.3 1.1 0.2 0.1 -0.6 -0.1 -1.1
Happiness 0.7 0.9 2.6 -0.5 -0.7 0.6 -0.9 1.6
Noisy workplace 0.3 0.4 1.5 0.4 0.5 -0.0 -0.0 -1.2
Qualifications: A levels/AS levels or equivalent 0.4 0.8 1.3 1.0 1.1 -1.0 0.5 -0.8
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.3 1.0 -0.4 -0.1 1.0 -0.4 0.3
Mouth/teeth dental problems: Dentures 0.8 1.3 5.0 -1.0 -0.8 -0.0 2.2 -0.1
Asthma 1.1 2.2 5.7 1.1 0.9 -1.5 2.4 -1.0
Medication: Ibuprofen (e.g. Nurofen) 3.9 4.9 10.0 2.0 2.0 -2.6 0.1 -3.2
Medication: Cholesterol lowering 0.8 1.3 4.0 -1.1 -1.1 2.0 0.1 0.4
Depression (self-reported) 0.4 0.4 1.2 -0.3 -0.4 1.1 -0.7 0.4
Medication: Lansoprazole 0.4 0.4 1.4 -0.3 -0.2 -0.3 0.8 -1.2
Prospective memory result 1.1 1.3 3.5 0.8 0.6 -1.9 1.4 -0.2
Lung cancer (father) 0.2 0.3 0.5 -0.4 -0.4 0.7 -0.6 -0.4
Illnesses of mother 0.1 0.1 0.3 -0.4 -0.2 0.3 -0.2 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 1.2 3.8 6.7 2.6 2.4 -1.6 -0.0 -2.0
Pulse wave Arterial Stiffness index 0.4 0.5 2.0 0.4 0.0 -0.2 1.4 -0.5
Impedance of arm (left) 0.1 0.7 1.5 -0.7 -1.0 -0.0 -1.2 -0.6
Arm fat mass (right) 0.3 1.1 4.4 0.0 0.1 2.1 -1.0 -0.2
Trunk predicted mass 1.2 6.9 10.8 3.2 3.3 -1.5 -0.8 -3.2
Standing height 1.6 15.8 31.8 4.4 4.1 -2.6 -2.3 -5.6
Length of working week for main job 2.8 3.1 5.1 2.0 2.3 -0.9 -1.4 -2.0
Exposure to tobacco smoke at home 0.4 0.5 1.0 0.1 0.2 -0.9 1.0 0.6
Breastfed as a baby 0.7 0.9 4.1 -0.2 -0.0 -0.3 0.4 -2.0
Tense / ‘highly strung’ 0.1 0.2 0.5 0.3 0.3 -0.7 -0.2 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.4 0.4 0.3 -0.2 0.5 0.6
Hair/balding pattern: Pattern 4 4.2 10.2 16.7 3.1 3.6 -2.3 4.1 -2.4
Birth weight of first child 0.3 0.5 1.2 -0.2 -0.4 0.9 -1.1 -0.6
Peak expiratory flow (PEF) 2.8 6.5 11.4 2.9 2.9 -3.4 0.9 -1.7
Pulse wave reflection index 0.6 0.7 2.8 0.5 0.4 -0.1 1.7 0.5
Ever highly irritable/argumentative for 2 days 1.8 2.2 5.4 -1.3 -1.4 1.2 -0.2 2.3
Loud music exposure frequency 1.9 2.0 5.4 -1.3 -1.2 2.3 -1.2 0.3
Qualifications: O levels/GCSEs or equivalent 0.1 0.1 0.4 -0.4 0.0 0.6 -0.3 -0.2
Mouth/teeth dental problems: Bleeding gums 0.6 0.7 2.2 -1.5 -0.9 -0.4 -0.2 0.7
Blood clot in the leg (DVT) 0.3 0.4 1.2 -0.2 -0.2 1.1 -0.1 0.9
Medication: Paracetamol 0.2 0.3 0.7 -0.2 -0.7 -0.4 -0.8 -0.2
Headache pain in last month 2.3 3.9 6.4 1.6 1.5 -2.5 2.3 -1.8
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 2.2 0.5 0.5 -1.5 -0.6 -0.8
Glaucoma (self-reported) 0.3 0.3 0.7 0.9 0.8 0.1 0.2 0.2
Gout (self-reported) 0.4 0.6 1.1 0.4 0.4 0.8 1.0 -1.0
Hypothyroidism/myxoedema (self-reported) 0.9 1.8 6.1 -0.8 -1.0 -0.2 1.0 2.5
Medication: Amlodipine 0.3 0.4 1.7 -0.1 -0.3 0.0 0.2 1.3
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.5 -0.1 0.4 -0.0 1.2 -1.0
Birth weight 0.4 0.9 2.9 0.3 0.2 1.7 -1.1 -0.7
Chronic bronchitis/emphysema (mother) 1.6 1.8 3.0 1.2 1.1 -1.7 1.3 -1.4
High blood pressure (siblings) 0.8 1.1 3.7 -0.5 -0.3 -1.0 1.9 0.6
Forced vital capacity (FVC), Best measure 0.8 2.9 5.7 1.7 1.2 -2.0 -0.1 -2.4
Body fat percentage 0.6 2.5 7.3 -1.2 -1.3 2.7 -1.1 1.0
Leg fat percentage (right) 0.8 2.9 6.6 -1.4 -1.5 2.6 0.0 1.9
Arm fat-free mass (right) 1.1 5.8 10.8 3.3 3.2 -1.4 -0.5 -2.4
Exposure to tobacco smoke outside home 1.7 2.3 5.6 -2.4 -2.3 -0.6 0.6 0.2
Comparative body size at age 10 0.6 1.6 5.1 -0.8 -0.7 2.3 0.0 1.4
Number of full brothers 1.2 1.5 3.6 -1.6 -1.9 -0.9 0.5 -0.7
Worry too long after embarrassment 0.5 0.8 1.5 -0.7 -0.9 -0.6 -1.2 -0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 1.3 -0.8 -1.0 0.6 -1.1 0.1
Wheeze or whistling in the chest in last year 0.3 0.5 0.6 -0.8 -0.8 0.4 0.7 -0.7
Number of children fathered 1.7 2.0 6.3 0.3 0.6 -1.3 2.5 1.2
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.2 0.4 0.1 0.3 -0.6 0.6 -0.1
Age at first live birth 0.6 1.1 3.6 0.9 0.6 1.9 -0.6 0.4
Pulse wave peak to peak time 0.5 0.5 2.6 -0.0 0.3 0.1 -1.6 0.1
Health satisfaction 0.1 0.1 0.3 0.1 -0.1 -0.6 0.1 0.4
Shortness of breath walking on level ground 0.2 0.2 0.4 0.6 0.5 -0.3 0.7 -0.4
Qualifications: College or University degree 0.4 1.1 3.1 -0.6 -0.7 1.2 -1.8 0.7
Eye problems/disorders: None of the above 0.3 0.4 0.7 0.8 0.8 -0.1 0.7 0.4
Mouth/teeth dental problems: Loose teeth 1.2 1.4 2.9 -1.0 -0.9 -1.2 1.1 1.7
Emphysema/chronic bronchitis 1.5 1.7 3.7 0.6 0.5 -1.8 0.9 -1.9
Medication for pain relief, constipation, heartburn 0.4 0.7 1.3 0.1 0.3 1.1 0.8 1.1
Neck or shoulder pain in last month 0.5 0.7 1.8 0.3 0.4 -1.3 1.2 0.3
Medication: Blood pressure 0.2 0.3 0.9 -0.3 -0.2 0.1 0.9 0.7
Angina (self-reported) 0.6 0.8 1.8 -1.3 -1.3 0.4 0.6 -0.2
Migraine (self-reported) 1.1 1.3 4.9 0.7 0.9 0.6 0.5 2.2
Medication: Ibuprofen 3.8 4.6 10.7 1.8 1.7 -2.5 0.1 -3.3
Medication: Allopurinol 0.3 0.3 0.9 0.3 0.1 0.8 1.0 -0.1
Medication: Omeprazole 0.5 0.5 1.8 -0.5 -0.6 -1.4 -0.2 -0.5
Medication: Seretide 50 evohaler 0.5 0.6 2.2 -0.5 -0.5 -0.2 1.5 0.5
Mean time to correctly identify matches 0.8 1.5 3.1 -0.8 -0.8 1.8 1.3 1.1
Heart disease (mother) 0.2 0.2 0.4 0.1 -0.0 0.5 -0.6 0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.7 0.6 0.8 -0.2 0.1 0.1
Whole body fat mass 0.2 1.0 3.6 0.0 -0.1 1.9 -1.2 -0.4
Leg fat mass (right) 0.2 0.9 3.8 -0.2 -0.3 2.0 -0.7 0.3
Arm predicted mass (right) 1.0 5.2 10.4 3.2 3.1 -1.3 -0.3 -2.1
Pulse rate, automated reading 0.1 0.4 0.8 -0.7 -0.9 0.7 -0.5 -0.3
Alcohol intake frequency. 0.6 1.3 6.1 0.0 -0.1 -0.4 -0.7 -2.5
Comparative height size at age 10 0.9 4.9 8.2 2.5 2.3 -1.6 -1.4 -2.9
Number of full sisters 0.4 0.5 1.3 0.5 0.6 -0.8 1.1 0.2
Suffer from ‘nerves’ 0.3 0.5 1.0 -0.8 -1.0 -0.1 -0.1 0.8
Overall health rating 0.2 0.5 1.7 -0.0 -0.0 -0.8 1.3 -0.1
Chest pain or discomfort 0.3 0.4 1.0 -0.5 -0.6 0.4 1.0 0.6
Had major operations 2.4 2.8 5.3 0.5 0.6 -2.2 1.8 -2.3
Age at last live birth 0.4 0.6 2.5 0.2 0.2 1.6 -0.3 0.5
Family relationship satisfaction 0.5 0.6 2.0 -0.3 -0.5 -0.3 -1.4 -0.9
Leg pain on walking 0.6 0.8 1.8 -0.6 -0.5 0.9 -0.9 1.3
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.3 0.7 0.2 -0.2 -0.8 -0.5 0.5
Commuting to job workplace: Car/motor vehicle 4.0 4.6 8.8 2.0 2.5 -3.0 1.9 -0.8
Illness, injury, bereavement, stress in last 2 years 0.6 0.8 2.9 -0.7 -0.5 0.2 0.2 1.7
Medication: Aspirin 0.4 0.5 2.0 -0.4 -0.3 -0.4 0.4 1.4
Supplements: Vitamin C 1.7 2.0 3.4 1.8 1.3 -1.9 -0.3 -1.3
Knee pain experienced in last month 1.7 2.6 5.3 1.5 1.3 -1.7 2.3 -0.8
Hypertension (Self-reported) 0.8 2.2 7.3 0.5 0.4 -1.0 2.7 1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 0.6 -0.8 -0.4 -0.7 0.0 -0.4
Illnesses of father: Heart disease 0.3 0.4 0.7 -0.8 -0.8 0.1 0.7 0.7
Illnesses of siblings: Diabetes 0.4 0.4 1.2 -0.8 -0.6 -0.2 -0.1 -1.1
Smoking status: Previous 1.3 1.9 6.2 -0.7 -0.8 -0.2 1.5 2.5
Forced expiratory volume in 1-second (FEV1), predicted 1.9 3.9 9.5 2.0 1.7 -1.7 -0.3 -3.1
Whole body fat-free mass 1.1 6.5 10.6 3.3 3.2 -1.0 -1.1 -3.1
Leg fat-free mass (right) 1.3 6.7 11.2 3.3 3.1 -0.7 -1.4 -3.2
Arm fat percentage (left) 0.6 2.6 7.6 -1.2 -1.2 2.8 -1.2 1.0
Average weekly red wine intake 1.4 2.0 3.7 -1.7 -1.7 0.8 -1.9 -0.1
Handedness (chirality/laterality): Left-handed 0.3 0.3 0.7 -0.6 -0.8 -0.0 0.7 0.2
Mood swings 0.8 1.4 5.6 -0.6 -0.7 -2.4 0.4 -0.6
Loneliness, isolation 0.6 0.8 2.1 -0.3 -0.7 -1.0 1.5 0.3
Long-standing illness, disability or infirmity 0.1 0.2 0.8 -0.3 -0.4 0.2 0.9 0.1
Ever had bowel cancer screening 0.5 0.6 1.7 0.0 0.2 0.8 0.7 1.3
Diabetes diagnosed by doctor 1.4 2.3 3.8 -1.8 -1.6 1.9 -1.4 -0.0
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.1 0.3 0.2 0.3 0.0 -0.3
Friendships satisfaction 0.1 0.2 0.8 0.2 0.0 -0.9 0.1 -0.2
Qualifications: nursing, teaching 0.4 0.6 1.1 0.9 1.0 1.0 -0.4 -0.1
Commuting to job workplace: Walk 2.6 2.8 10.2 -0.1 -0.3 2.0 -3.2 -0.1
Eye problems/disorders: Cataract 0.8 1.0 2.2 -1.4 -1.5 0.3 -0.1 0.8
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 1.2 -0.3 -0.6 -0.7 -0.6 -1.1
Medication for cholesterol 0.7 1.1 2.7 -0.3 -0.0 1.5 -1.6 -0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 0.9 -0.6 -1.0 -0.9 0.2 -0.3
Back pain experienced in last month 2.2 3.1 5.1 2.0 1.8 -1.6 0.9 -2.3
Mineral and other dietary supplements 1.2 1.6 4.2 -0.8 -1.0 2.0 -1.3 0.4
Breast cancer (self-reported) 0.7 0.9 1.9 0.7 0.6 -1.2 0.4 -1.4
Asthma (self-reported) 1.4 2.9 6.7 1.4 1.2 -1.6 2.6 -1.2
Osteoporosis (self-reported) 0.2 0.2 0.4 -0.5 -0.5 0.1 0.7 0.1
Osteoarthritis (self-reported) 0.3 0.4 1.4 -0.4 -0.4 -0.2 0.5 -1.2
Medication: Aspirin 0.2 0.3 1.0 -0.2 0.0 -0.5 0.5 1.0
Medication: Gliclazide 1.0 1.1 2.5 -1.6 -1.0 -1.0 1.0 0.4
Illnesses of father: None of the above (group 1) 2.9 3.6 8.9 -1.8 -2.0 1.4 -3.0 0.1
Smoking status: Current 0.8 1.3 2.4 -1.2 -1.3 1.6 -0.7 0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 0.5 0.1 -0.1 -0.7 0.7 0.4
Whole body water mass 1.1 6.2 10.5 3.2 3.1 -1.1 -1.1 -2.8
Leg predicted mass (right) 1.2 6.6 11.2 3.3 3.1 -0.7 -1.3 -3.1
Arm fat mass (left) 0.2 0.8 2.8 0.0 -0.0 1.7 -1.0 -0.2
Number of self-reported non-cancer illnesses 2.2 3.9 12.5 1.2 1.3 -1.8 3.5 -0.3
Average weekly champagne plus white wine intake 1.2 1.6 2.4 -1.5 -1.3 1.0 -1.6 0.8
Miserableness 0.7 1.2 1.6 -1.3 -1.3 -1.0 -0.8 -1.2
Guilty feelings 1.6 2.4 6.2 1.1 0.7 -2.5 2.0 -0.4
Wears glasses or contact lenses 1.4 1.6 3.5 -1.5 -1.9 1.3 0.4 0.3
Ever taken oral contraceptive pill 0.3 0.4 0.7 -0.8 -0.8 0.3 -0.7 0.2
Hearing aid user 0.7 0.8 2.4 0.5 0.3 -1.1 0.1 -1.5
Mother’s age at death 0.4 0.5 1.3 -1.2 -0.9 -0.2 -0.5 0.5
Financial situation satisfaction 0.2 0.2 0.5 0.3 0.1 0.2 -0.6 -0.7
Tinnitus: Yes, now most or all of the time 0.5 0.5 2.2 -0.3 -0.3 -0.5 1.5 0.3
Commuting to job workplace: Public transport 2.8 3.3 6.0 -1.8 -2.2 1.6 -2.5 -0.2
Eye problems/disorders: Glaucoma 0.6 0.7 1.2 1.1 0.9 0.5 0.4 1.1
Medication: Blood pressure 1.6 3.1 9.5 0.6 0.5 -1.0 3.1 2.1
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.2 -0.7 -0.6 -0.3 0.7 -1.1
Supplements: Fish oil (including cod liver oil) 1.4 1.9 3.8 1.2 1.2 -2.0 1.3 -1.0
High cholesterol (Self-reported) 0.2 0.4 1.8 -0.4 -0.3 0.1 -0.2 -1.4
Medication: Bendroflumethiazide 1.0 1.5 4.5 0.9 1.1 -0.4 2.1 1.0
Medication: Paracetamol 0.2 0.3 0.8 0.1 -0.4 -0.7 -0.4 -0.9
Medication: Lisinopril 0.2 0.3 1.0 0.4 0.2 -0.6 1.0 0.1
Medication: Atorvastatin 0.5 0.6 1.5 -1.1 -1.2 0.5 -0.3 -0.4
Illnesses of father: High blood pressure 2.4 3.0 7.0 1.3 1.4 -0.7 2.6 1.9
Alcohol drinker status: Never 0.9 1.1 2.1 -0.9 -1.3 1.5 -0.2 0.9
Ever smoked 1.2 2.1 7.1 -0.3 -0.3 0.1 1.7 2.7
Basal metabolic rate 0.9 5.2 8.8 3.0 2.9 -0.7 -1.0 -2.8
Leg fat percentage (left) 0.7 2.4 6.7 -1.1 -1.2 2.6 0.2 1.6
Arm fat-free mass (left) 0.9 4.7 8.1 2.8 2.9 -0.9 -0.4 -2.5
Number of operations (self-reported) 1.2 1.9 3.8 0.4 0.5 -1.9 1.9 -1.3
Average weekly beer plus cider intake 1.3 1.9 5.2 1.2 1.4 -0.9 -0.2 -2.3
Irritability 0.3 0.4 0.9 -0.8 -0.9 -0.0 -0.8 0.0
Risk taking 0.5 0.7 2.7 0.2 0.1 0.6 -0.6 1.6
Ever had prostate specific antigen (PSA) test 1.1 1.2 2.9 -0.6 -0.1 1.7 -0.3 1.7
Fractured/broken bones in last 5 years 0.2 0.3 1.2 0.1 -0.2 0.3 1.1 -0.4
Age started oral contraceptive pill 0.7 0.9 2.0 -1.4 -1.3 -0.5 0.1 0.8
Diastolic blood pressure, automated reading 0.7 2.3 8.6 0.4 0.5 1.2 1.1 2.9
Ever depressed for a whole week 3.1 3.8 5.8 -2.4 -2.3 1.2 -2.1 1.5
Unable to work because of sickness or disability 0.3 0.3 0.8 0.1 -0.4 -0.2 0.8 -0.9
Commuting to job workplace: Cycle 0.7 0.9 2.6 0.7 0.3 -1.0 -0.5 -1.6
Myopia 2.7 3.9 5.7 -2.4 -2.1 2.0 -0.7 2.2
Vascular/heart problems diagnosed by doctor 0.6 1.6 4.1 -0.2 -0.2 0.1 -2.0 -2.0
Cholesterol lowering medication 0.2 0.3 0.5 -0.6 -0.7 -0.1 0.6 0.2
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 1.3 -1.0 -1.0 -1.1 -0.7 -1.1
Pain experienced in last month 3.2 5.3 8.0 -2.5 -2.2 2.8 -1.5 2.2
Supplements: Calcium 3.0 3.3 8.6 1.5 1.3 -2.9 1.6 -1.2
Basal cell carcinoma (self-reported) 2.5 3.0 6.0 2.3 2.4 -1.2 1.4 -0.5
Heart attack/myocardial infarction (self-reported) 0.3 0.4 0.8 -0.9 -0.9 -0.1 0.6 -0.3
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 1.6 -0.6 -0.6 1.3 -0.1 1.2
Heart disease (siblings) 1.5 1.8 3.8 -0.9 -0.4 1.9 -1.6 1.3
Alcohol drinker status: Previous 0.8 0.9 1.6 -1.3 -1.2 0.8 -0.8 0.5
Pack years of smoking 0.7 1.0 3.7 -0.4 -0.7 0.1 0.7 1.9
Impedance of whole body 0.1 0.4 1.0 -0.7 -1.0 -0.1 -0.4 -0.5
Leg fat mass (left) 0.2 0.7 3.3 0.1 -0.0 1.8 -0.4 0.2
Arm predicted mass (left) 0.9 4.5 8.1 2.9 2.8 -1.0 -0.4 -2.3