Hub : Genes

SMOX

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0568	0.0154	1.5e-05	0.031	0.013	0.028	0.025	0.033	3.0e-10	2.7e-05	2.2e-09	1.5e-08	6.5e-11
2	YFS	Blood	0.4412	0.0306	0.0e+00	0.367	0.346	0.425	0.322	0.416	2.0e-127	1.4e-118	4.0e-154	6.1e-109	8.9e-150
3	TCGA	Colon Adenocarcinoma	0.1650	0.0500	3.8e-06	0.049	0.116	0.052	NA	0.081	7.9e-04	3.3e-07	5.8e-04	NA	2.0e-05
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.0394	0.0194	8.2e-03	-0.001	0.011	0.019	NA	0.002	3.8e-01	1.8e-02	3.0e-03	NA	1.7e-01
5	TCGA	Testicular Germ Cell Tumors	0.3090	0.0880	2.8e-04	0.054	0.053	0.038	NA	0.074	5.5e-03	5.9e-03	1.7e-02	NA	1.3e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.5	0.7	1.3	1.1	1.0	1.1	-0.0	0.1
Bipolar Disorder or Schizophrenia	0.2	0.5	1.1	-0.2	-0.4	1.1	1.0	0.5
Depressed Affect (Nagel 2018)	0.8	1.7	5.4	-1.2	-1.2	-2.3	0.2	-0.3
Depression (Nagel 2018)	0.8	1.2	2.9	-1.7	-1.5	-0.0	-0.0	0.9
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.3	-0.3	-0.2	-0.2	-0.6	-0.6
Neuroticism (Nagel 2018)	0.5	1.3	3.2	-1.3	-1.2	-1.8	0.1	0.3
Schizophrenia (2018)	0.5	1.0	1.7	-1.1	-1.3	0.5	1.2	0.6
Schizophrenia vs Biploar Disorder	0.9	1.2	2.4	-1.5	-1.5	0.3	-0.1	-1.2
Worry (Nagel 2018)	0.3	0.7	1.5	-1.2	-1.0	-0.6	-0.4	0.6
Alzheimer’s Disease (in mother)	0.4	0.5	1.3	0.7	0.6	1.1	-0.2	0.5
Alzheimer’s Disease (in father)	1.1	1.2	5.8	0.1	0.0	-0.5	-0.3	-2.4
Alzheimer’s Disease (including proxy)	0.9	1.3	3.1	1.2	1.3	0.1	0.3	-1.8
Crohns Disease (2017)	0.9	1.9	4.5	0.7	0.8	-1.9	2.1	0.3
Irritable Bowel Disease (IBD)	0.2	0.4	0.7	0.7	0.5	-0.3	0.8	0.6
Ulcerative Colitis (UC)	0.1	0.1	0.3	0.4	0.0	0.5	-0.4	0.4
Major Depression (MDD)	2.0	2.4	5.2	-0.2	-0.6	2.3	-1.8	1.8
Reaction Time	0.3	0.6	2.6	-0.0	-0.3	1.6	0.2	-0.6
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.7	-0.7	-0.4	0.8	0.0	-0.4
Breast Cancer	0.2	0.5	1.4	-0.3	0.0	-0.2	0.9	1.2
Ovarian Cancer	0.2	0.2	0.5	0.7	0.6	-0.0	0.5	0.2
Prostate Cancer	2.7	3.8	7.2	-2.6	-2.7	1.4	-1.7	0.0
Age at First Birth	0.9	1.3	2.1	-1.4	-1.4	1.0	-0.8	0.9
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.2	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.2	0.3	1.0	0.1	0.2	-0.5	-0.0	-1.0
Coronary Artery Disease (CAD)	0.9	1.1	1.8	-1.4	-1.1	0.7	-0.5	1.2
Crohns Disease (2012)	0.5	0.8	1.5	0.7	0.7	-0.3	1.2	1.2
Mean Putamen Volume	1.7	2.0	3.4	1.4	1.6	-0.7	1.2	1.8
Fasting Glucose	0.1	0.1	0.6	-0.0	0.1	-0.8	0.3	-0.2
HbA1C	1.0	1.1	2.1	1.1	1.4	-0.8	1.2	-0.2
HDL Cholesterol	0.8	1.4	2.5	1.2	1.1	-1.6	1.0	-0.7
LDL Cholesterol	1.1	1.7	2.7	-1.6	-1.4	0.8	-1.6	0.6
Lupus	0.1	0.1	0.3	-0.3	-0.6	0.2	0.3	0.2
Neuroticism (2016)	0.4	0.5	1.5	0.3	0.3	-1.2	0.2	-0.9
Primary Biliary Cirrhosis	1.1	1.6	2.7	-1.7	-1.4	1.3	-0.9	0.9
Rheumatoid Arthritis	0.6	0.8	3.7	-0.2	-0.4	0.5	-0.1	1.9
Schizophrenia (2014)	0.6	1.3	2.7	-1.3	-1.3	1.7	0.0	0.4
Triglycerides	1.1	1.8	4.2	-1.1	-1.2	0.2	-1.4	-2.1
Type 2 Diabetes (T2D) (2012)	1.0	1.1	2.7	0.2	0.3	-1.7	1.3	-1.1
Ulcerative Colitis	0.6	0.9	2.6	-0.3	-0.6	1.0	-1.6	0.7
Blood Eosinophil Count	0.1	0.9	2.6	0.1	0.2	0.0	-1.3	-1.6
Blood Platelet Count	0.1	1.3	2.0	-1.2	-0.9	1.4	-0.1	1.4
Blood Red Count	0.6	5.4	10.7	2.6	2.6	-0.6	3.3	1.6
Blood White Count	3.7	27.4	40.4	-6.3	-6.4	4.6	-3.2	5.0
Heel T-Score	0.1	0.6	1.4	-1.2	-0.6	0.5	1.0	0.4
BMI	0.4	2.6	9.9	-1.0	-0.9	3.2	-1.1	0.3
Height	0.8	14.5	30.9	3.8	3.5	-3.1	-2.3	-5.6
Waist Hip Ratio (WHR)	0.2	1.1	2.5	-1.4	-1.6	0.4	-0.0	1.0
Systolic Blood Pressure	1.3	6.4	15.3	2.0	2.1	-2.3	3.9	1.7
Smoking Status	0.7	1.6	5.8	-0.9	-0.9	0.9	0.2	2.4
Allergy or Eczema	1.3	3.4	6.0	1.9	1.9	-2.5	0.2	-1.9
Cardiovascular Disease	0.4	1.3	4.7	-0.2	-0.4	-0.9	2.2	1.0
Hypothyroidism (self reported)	1.7	3.8	7.6	-2.2	-2.5	0.3	0.5	2.8
Respiratory disease	1.6	3.6	5.3	1.7	1.8	-1.4	2.1	-2.3
Type 2 Diabetes (T2D) (2018)	1.0	1.9	3.3	-1.8	-1.5	1.4	-1.3	-0.0
Lung FEV1/FVC ratio	1.0	5.0	12.1	3.0	3.5	-0.8	0.9	-1.6
Lung FVC	0.3	1.4	4.0	-0.9	-1.1	0.6	0.6	2.0
Neuroticism	0.8	1.9	3.2	-1.8	-1.8	-1.7	-0.4	-0.1
Chronotype (morning person)	0.2	0.5	1.9	0.2	0.4	-0.5	0.1	-1.4
Hair Pigment	0.2	4.6	8.1	-2.1	-2.2	2.8	-2.2	0.9
Tanning	0.1	1.4	4.5	-0.6	-0.2	1.5	-2.1	0.3
Hand grip strength (left)	0.9	2.3	5.8	2.2	2.4	-0.9	0.1	-0.2
Number of treatments/medications taken	1.0	1.7	5.8	0.9	0.7	-1.0	2.4	-0.7
Average weekly spirits intake	0.2	0.3	0.5	0.5	0.7	-0.7	-0.5	-0.0
Sensitivity / hurt feelings	0.7	1.2	3.0	-0.5	-0.9	-1.2	0.7	1.7
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.9	-0.8	-1.0	-0.5	0.4	0.2
Hearing difficulty/problems: Yes	0.8	1.2	2.8	1.7	1.7	-0.3	0.5	-0.2
Relative age of first facial hair	0.4	0.9	1.4	-1.1	-1.2	-1.1	-0.1	-0.9
Other serious medical condition/disability diagnosed by doctor	1.1	1.5	2.4	1.5	1.5	1.1	1.2	0.1
Ever used hormone-replacement therapy (HRT)	1.7	2.1	4.7	1.3	1.2	-1.6	2.2	-0.0
Ever had hysterectomy (womb removed)	0.6	0.7	1.8	0.5	0.2	-1.3	1.2	-0.2
Systolic blood pressure, automated reading	1.1	3.2	7.5	1.0	1.1	-0.2	2.7	2.5
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	2.2	-1.4	-1.5	0.2	-1.3	1.1
Angina	0.5	0.7	1.4	-1.1	-1.2	0.5	0.8	-0.2
Medication for hormone replacement therapy	0.4	0.4	1.7	0.4	0.2	-1.3	-0.4	0.1
Vitamin and mineral supplements	1.6	2.2	6.9	-0.7	-0.6	2.6	0.4	1.7
Supplements: Zinc	1.8	1.9	4.7	2.2	1.8	-1.2	0.6	0.2
Medication: Co-codamol	0.3	0.4	0.9	-0.7	-0.9	0.5	-0.5	0.1
Medication: Metformin	1.2	1.8	3.5	-1.5	-1.2	1.9	-0.8	0.9
Diabetes (father)	1.2	1.4	3.0	-1.7	-1.7	0.7	-0.6	-0.6
Diabetes (mother)	1.2	1.5	2.7	-1.1	-1.2	1.6	-0.7	1.3
Severe depression (siblings)	1.2	1.4	2.9	1.5	1.7	-0.1	0.8	1.0
Pack years adult smoking proportion	0.4	0.6	2.3	0.0	-0.4	-0.3	0.7	1.5
Impedance of leg (right)	0.2	1.0	2.4	-1.4	-1.5	-0.6	0.1	0.6
Leg fat-free mass (left)	1.0	5.2	8.8	3.0	2.7	-0.4	-1.5	-2.7
Trunk fat percentage	0.4	1.7	5.6	-0.6	-0.8	2.4	-1.2	0.4
Hand grip strength (right)	0.7	1.9	4.0	2.0	2.0	-1.2	0.5	0.2
Townsend deprivation index at recruitment	2.1	3.0	4.2	-1.8	-2.0	1.8	-2.1	-0.7
Current tobacco smoking	1.0	1.6	2.7	-1.4	-1.6	1.5	-0.8	0.9
Average weekly fortified wine intake	1.5	1.8	3.2	-1.6	-1.1	-1.8	1.2	-0.7
Maternal smoking around birth	0.4	0.5	1.7	-0.1	-0.3	-1.3	0.9	0.2
Fed-up feelings	0.6	1.1	5.4	0.1	-0.1	-2.3	-0.0	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	3.2	-1.8	-1.7	0.2	0.4	0.9
Relative age voice broke	0.3	0.4	1.7	-0.1	-0.3	0.4	-1.3	-0.4
Taking other prescription medications	1.3	2.0	9.0	0.2	-0.0	-0.7	3.0	-0.9
Age when periods started (menarche)	0.3	0.7	1.4	0.3	0.5	-1.0	0.9	-1.2
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.4	0.5	0.4	-1.3	1.5	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.6	-0.3	0.0	0.3	0.9	1.3
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	7.4	0.6	0.7	1.0	0.3	2.7
Qualifications: CSEs or equivalent	1.1	1.5	3.2	1.8	1.5	0.6	-0.4	-1.1
Serious illness, injury or assault to yourself	4.6	5.5	7.9	2.8	2.4	-1.9	2.8	-1.7
High blood pressure	0.8	2.3	6.8	0.8	0.8	-1.2	2.6	1.4
Hayfever, allergic rhinitis or eczema	0.8	1.8	3.2	1.6	1.3	-1.8	-0.6	-1.0
Multivitamins +/- minerals	1.5	1.9	4.3	-0.8	-0.9	-1.0	-1.6	-2.1
Stomach or abdominal pain in last month	0.6	0.7	1.8	-0.3	-0.3	-0.5	-1.3	-1.2
Supplements: Glucosamine	0.5	0.6	1.0	-1.0	-0.8	0.6	-0.8	0.7
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	-0.0	0.5	0.3	-0.2	0.2
Medication: Atenolol	1.3	1.6	3.2	-1.8	-1.6	1.1	0.3	0.9
Medication: Levothyroxine sodium	0.6	1.0	2.2	-0.5	-0.9	-0.0	1.3	1.5
Sitting height	0.9	6.3	13.8	2.2	2.2	-1.9	-2.1	-3.7
Chronic bronchitis/emphysema (father)	0.9	1.1	5.4	0.1	0.1	0.0	2.3	0.3
High blood pressure (mother)	0.3	0.4	0.7	0.3	0.5	-0.9	0.8	-0.7
Body mass index (BMI)	0.2	1.0	4.4	-0.3	-0.2	2.1	-0.3	0.8
Impedance of leg (left)	0.2	0.8	1.7	-1.2	-1.3	-0.7	0.6	0.1
Leg predicted mass (left)	1.0	5.1	8.7	3.0	2.7	-0.4	-1.5	-2.6
Trunk fat mass	0.3	1.2	3.6	0.3	0.2	1.9	-1.4	-0.4
Waist circumference	0.3	1.2	4.3	-0.5	-0.5	2.1	-1.0	-0.2
Number of incorrect matches in round	0.9	1.5	2.7	0.9	1.0	-1.5	1.6	0.9
Past tobacco smoking	1.7	3.2	10.3	1.2	1.3	-0.7	-1.4	-3.2
Alcohol usually taken with meals	1.2	2.0	3.0	-1.7	-1.7	1.5	-1.1	0.9
Nervous feelings	0.5	0.9	1.9	-1.3	-1.4	0.6	-0.7	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	3.4	-1.7	-1.8	0.8	0.1	0.5
Hearing difficulty/problems with background noise	0.3	0.4	1.1	-0.3	-0.2	1.0	0.4	0.9
Hair/balding pattern: Pattern 2	1.0	1.2	2.8	-1.6	-1.7	-0.2	0.3	0.8
Had menopause	1.8	2.2	4.8	-1.8	-1.4	0.7	0.7	2.2
Had other major operations	0.2	0.2	0.4	0.3	0.0	-0.7	-0.6	-0.5
Forced vital capacity (FVC)	1.2	4.8	9.3	2.2	1.8	-3.1	0.7	-2.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.1	0.3	-0.3	-0.1	-0.3	0.6	0.1
Ever unenthusiastic/disinterested for a whole week	3.0	3.7	7.2	-1.3	-1.5	2.1	-2.7	1.6
Qualifications: None of the above	0.3	0.6	0.9	-1.0	-1.0	-0.7	0.7	0.1
Financial difficulties in last 2 years	0.3	0.5	1.5	0.1	-0.4	0.8	-1.2	-0.2
Mouth/teeth dental problems	1.2	1.9	4.5	2.1	1.6	1.0	-1.3	0.3
Heart attack	0.5	0.6	1.3	-1.1	-1.1	0.0	0.6	0.0
Allergy	1.3	2.9	4.6	-2.1	-1.8	2.1	-0.8	1.4
Pain all over the body in last month	1.7	1.9	2.1	1.5	1.4	-1.4	1.1	-1.4
Diabetes (self-reported)	1.4	2.2	3.2	-1.6	-1.5	1.8	-1.6	0.6
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	3.6	1.9	1.7	-0.4	0.4	-0.7
Medication: Ramipril	0.6	0.7	2.0	-0.7	-0.2	0.9	1.4	0.6
Medication: Simvastatin	0.2	0.3	0.6	-0.8	-0.8	0.3	0.5	-0.2
Fluid intelligence score	0.2	0.3	0.6	-0.7	-0.6	0.8	-0.5	-0.1
Illnesses of siblings	0.4	0.6	0.9	0.9	0.9	-0.5	-0.4	-0.9
Neuroticism score	0.5	1.1	2.3	-1.0	-1.4	-1.5	-0.4	-0.2
Weight	0.4	2.0	3.0	1.6	1.5	0.8	-1.2	-1.7
Impedance of arm (right)	0.3	1.4	3.0	-1.1	-1.1	1.0	-1.7	-0.7
Arm fat percentage (right)	0.9	3.5	11.0	-1.3	-1.3	3.3	-1.4	1.0
Trunk fat-free mass	1.1	6.5	10.4	3.2	3.2	-1.4	-0.8	-3.1
Hip circumference	0.5	2.1	3.9	1.0	1.0	2.0	-1.6	-1.5
Time employed in main current job	0.7	0.8	1.5	0.5	0.9	1.0	0.5	1.2
Alcohol intake versus 10 years previously	0.3	0.5	1.0	-0.4	-0.3	-0.7	0.7	-1.0
Father’s age at death	1.1	1.5	4.1	0.7	0.8	2.0	-1.2	1.1
Worrier / anxious feelings	0.3	0.6	1.7	-0.5	-0.4	-0.9	-0.1	-1.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	0.9	-0.7	-0.9	-0.6	0.7	0.4
Falls in the last year	0.1	0.2	0.7	0.3	-0.0	-0.0	0.8	-0.3
Hair/balding pattern: Pattern 3	1.4	2.1	3.6	1.9	1.5	-0.7	1.5	1.5
Number of live births	1.3	1.8	3.0	1.1	1.3	-0.5	1.7	-1.7
Forced expiratory volume in 1-second (FEV1)	2.2	7.3	10.8	3.3	3.1	-3.1	1.1	-2.4
Pulse rate	0.2	0.3	1.1	0.2	0.1	-0.6	-0.1	-1.1
Happiness	0.7	0.9	2.6	-0.5	-0.7	0.6	-0.9	1.6
Noisy workplace	0.3	0.4	1.5	0.4	0.5	-0.0	-0.0	-1.2
Qualifications: A levels/AS levels or equivalent	0.4	0.8	1.3	1.0	1.1	-1.0	0.5	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	1.0	-0.4	-0.1	1.0	-0.4	0.3
Mouth/teeth dental problems: Dentures	0.8	1.3	5.0	-1.0	-0.8	-0.0	2.2	-0.1
Asthma	1.1	2.2	5.7	1.1	0.9	-1.5	2.4	-1.0
Medication: Ibuprofen (e.g. Nurofen)	3.9	4.9	10.0	2.0	2.0	-2.6	0.1	-3.2
Medication: Cholesterol lowering	0.8	1.3	4.0	-1.1	-1.1	2.0	0.1	0.4
Depression (self-reported)	0.4	0.4	1.2	-0.3	-0.4	1.1	-0.7	0.4
Medication: Lansoprazole	0.4	0.4	1.4	-0.3	-0.2	-0.3	0.8	-1.2
Prospective memory result	1.1	1.3	3.5	0.8	0.6	-1.9	1.4	-0.2
Lung cancer (father)	0.2	0.3	0.5	-0.4	-0.4	0.7	-0.6	-0.4
Illnesses of mother	0.1	0.1	0.3	-0.4	-0.2	0.3	-0.2	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.8	6.7	2.6	2.4	-1.6	-0.0	-2.0
Pulse wave Arterial Stiffness index	0.4	0.5	2.0	0.4	0.0	-0.2	1.4	-0.5
Impedance of arm (left)	0.1	0.7	1.5	-0.7	-1.0	-0.0	-1.2	-0.6
Arm fat mass (right)	0.3	1.1	4.4	0.0	0.1	2.1	-1.0	-0.2
Trunk predicted mass	1.2	6.9	10.8	3.2	3.3	-1.5	-0.8	-3.2
Standing height	1.6	15.8	31.8	4.4	4.1	-2.6	-2.3	-5.6
Length of working week for main job	2.8	3.1	5.1	2.0	2.3	-0.9	-1.4	-2.0
Exposure to tobacco smoke at home	0.4	0.5	1.0	0.1	0.2	-0.9	1.0	0.6
Breastfed as a baby	0.7	0.9	4.1	-0.2	-0.0	-0.3	0.4	-2.0
Tense / ‘highly strung’	0.1	0.2	0.5	0.3	0.3	-0.7	-0.2	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.4	0.4	0.3	-0.2	0.5	0.6
Hair/balding pattern: Pattern 4	4.2	10.2	16.7	3.1	3.6	-2.3	4.1	-2.4
Birth weight of first child	0.3	0.5	1.2	-0.2	-0.4	0.9	-1.1	-0.6
Peak expiratory flow (PEF)	2.8	6.5	11.4	2.9	2.9	-3.4	0.9	-1.7
Pulse wave reflection index	0.6	0.7	2.8	0.5	0.4	-0.1	1.7	0.5
Ever highly irritable/argumentative for 2 days	1.8	2.2	5.4	-1.3	-1.4	1.2	-0.2	2.3
Loud music exposure frequency	1.9	2.0	5.4	-1.3	-1.2	2.3	-1.2	0.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.4	-0.4	0.0	0.6	-0.3	-0.2
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	2.2	-1.5	-0.9	-0.4	-0.2	0.7
Blood clot in the leg (DVT)	0.3	0.4	1.2	-0.2	-0.2	1.1	-0.1	0.9
Medication: Paracetamol	0.2	0.3	0.7	-0.2	-0.7	-0.4	-0.8	-0.2
Headache pain in last month	2.3	3.9	6.4	1.6	1.5	-2.5	2.3	-1.8
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.2	0.5	0.5	-1.5	-0.6	-0.8
Glaucoma (self-reported)	0.3	0.3	0.7	0.9	0.8	0.1	0.2	0.2
Gout (self-reported)	0.4	0.6	1.1	0.4	0.4	0.8	1.0	-1.0
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	6.1	-0.8	-1.0	-0.2	1.0	2.5
Medication: Amlodipine	0.3	0.4	1.7	-0.1	-0.3	0.0	0.2	1.3
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.5	-0.1	0.4	-0.0	1.2	-1.0
Birth weight	0.4	0.9	2.9	0.3	0.2	1.7	-1.1	-0.7
Chronic bronchitis/emphysema (mother)	1.6	1.8	3.0	1.2	1.1	-1.7	1.3	-1.4
High blood pressure (siblings)	0.8	1.1	3.7	-0.5	-0.3	-1.0	1.9	0.6
Forced vital capacity (FVC), Best measure	0.8	2.9	5.7	1.7	1.2	-2.0	-0.1	-2.4
Body fat percentage	0.6	2.5	7.3	-1.2	-1.3	2.7	-1.1	1.0
Leg fat percentage (right)	0.8	2.9	6.6	-1.4	-1.5	2.6	0.0	1.9
Arm fat-free mass (right)	1.1	5.8	10.8	3.3	3.2	-1.4	-0.5	-2.4
Exposure to tobacco smoke outside home	1.7	2.3	5.6	-2.4	-2.3	-0.6	0.6	0.2
Comparative body size at age 10	0.6	1.6	5.1	-0.8	-0.7	2.3	0.0	1.4
Number of full brothers	1.2	1.5	3.6	-1.6	-1.9	-0.9	0.5	-0.7
Worry too long after embarrassment	0.5	0.8	1.5	-0.7	-0.9	-0.6	-1.2	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.3	-0.8	-1.0	0.6	-1.1	0.1
Wheeze or whistling in the chest in last year	0.3	0.5	0.6	-0.8	-0.8	0.4	0.7	-0.7
Number of children fathered	1.7	2.0	6.3	0.3	0.6	-1.3	2.5	1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.4	0.1	0.3	-0.6	0.6	-0.1
Age at first live birth	0.6	1.1	3.6	0.9	0.6	1.9	-0.6	0.4
Pulse wave peak to peak time	0.5	0.5	2.6	-0.0	0.3	0.1	-1.6	0.1
Health satisfaction	0.1	0.1	0.3	0.1	-0.1	-0.6	0.1	0.4
Shortness of breath walking on level ground	0.2	0.2	0.4	0.6	0.5	-0.3	0.7	-0.4
Qualifications: College or University degree	0.4	1.1	3.1	-0.6	-0.7	1.2	-1.8	0.7
Eye problems/disorders: None of the above	0.3	0.4	0.7	0.8	0.8	-0.1	0.7	0.4
Mouth/teeth dental problems: Loose teeth	1.2	1.4	2.9	-1.0	-0.9	-1.2	1.1	1.7
Emphysema/chronic bronchitis	1.5	1.7	3.7	0.6	0.5	-1.8	0.9	-1.9
Medication for pain relief, constipation, heartburn	0.4	0.7	1.3	0.1	0.3	1.1	0.8	1.1
Neck or shoulder pain in last month	0.5	0.7	1.8	0.3	0.4	-1.3	1.2	0.3
Medication: Blood pressure	0.2	0.3	0.9	-0.3	-0.2	0.1	0.9	0.7
Angina (self-reported)	0.6	0.8	1.8	-1.3	-1.3	0.4	0.6	-0.2
Migraine (self-reported)	1.1	1.3	4.9	0.7	0.9	0.6	0.5	2.2
Medication: Ibuprofen	3.8	4.6	10.7	1.8	1.7	-2.5	0.1	-3.3
Medication: Allopurinol	0.3	0.3	0.9	0.3	0.1	0.8	1.0	-0.1
Medication: Omeprazole	0.5	0.5	1.8	-0.5	-0.6	-1.4	-0.2	-0.5
Medication: Seretide 50 evohaler	0.5	0.6	2.2	-0.5	-0.5	-0.2	1.5	0.5
Mean time to correctly identify matches	0.8	1.5	3.1	-0.8	-0.8	1.8	1.3	1.1
Heart disease (mother)	0.2	0.2	0.4	0.1	-0.0	0.5	-0.6	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.7	0.6	0.8	-0.2	0.1	0.1
Whole body fat mass	0.2	1.0	3.6	0.0	-0.1	1.9	-1.2	-0.4
Leg fat mass (right)	0.2	0.9	3.8	-0.2	-0.3	2.0	-0.7	0.3
Arm predicted mass (right)	1.0	5.2	10.4	3.2	3.1	-1.3	-0.3	-2.1
Pulse rate, automated reading	0.1	0.4	0.8	-0.7	-0.9	0.7	-0.5	-0.3
Alcohol intake frequency.	0.6	1.3	6.1	0.0	-0.1	-0.4	-0.7	-2.5
Comparative height size at age 10	0.9	4.9	8.2	2.5	2.3	-1.6	-1.4	-2.9
Number of full sisters	0.4	0.5	1.3	0.5	0.6	-0.8	1.1	0.2
Suffer from ‘nerves’	0.3	0.5	1.0	-0.8	-1.0	-0.1	-0.1	0.8
Overall health rating	0.2	0.5	1.7	-0.0	-0.0	-0.8	1.3	-0.1
Chest pain or discomfort	0.3	0.4	1.0	-0.5	-0.6	0.4	1.0	0.6
Had major operations	2.4	2.8	5.3	0.5	0.6	-2.2	1.8	-2.3
Age at last live birth	0.4	0.6	2.5	0.2	0.2	1.6	-0.3	0.5
Family relationship satisfaction	0.5	0.6	2.0	-0.3	-0.5	-0.3	-1.4	-0.9
Leg pain on walking	0.6	0.8	1.8	-0.6	-0.5	0.9	-0.9	1.3
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.7	0.2	-0.2	-0.8	-0.5	0.5
Commuting to job workplace: Car/motor vehicle	4.0	4.6	8.8	2.0	2.5	-3.0	1.9	-0.8
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	2.9	-0.7	-0.5	0.2	0.2	1.7
Medication: Aspirin	0.4	0.5	2.0	-0.4	-0.3	-0.4	0.4	1.4
Supplements: Vitamin C	1.7	2.0	3.4	1.8	1.3	-1.9	-0.3	-1.3
Knee pain experienced in last month	1.7	2.6	5.3	1.5	1.3	-1.7	2.3	-0.8
Hypertension (Self-reported)	0.8	2.2	7.3	0.5	0.4	-1.0	2.7	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.6	-0.8	-0.4	-0.7	0.0	-0.4
Illnesses of father: Heart disease	0.3	0.4	0.7	-0.8	-0.8	0.1	0.7	0.7
Illnesses of siblings: Diabetes	0.4	0.4	1.2	-0.8	-0.6	-0.2	-0.1	-1.1
Smoking status: Previous	1.3	1.9	6.2	-0.7	-0.8	-0.2	1.5	2.5
Forced expiratory volume in 1-second (FEV1), predicted	1.9	3.9	9.5	2.0	1.7	-1.7	-0.3	-3.1
Whole body fat-free mass	1.1	6.5	10.6	3.3	3.2	-1.0	-1.1	-3.1
Leg fat-free mass (right)	1.3	6.7	11.2	3.3	3.1	-0.7	-1.4	-3.2
Arm fat percentage (left)	0.6	2.6	7.6	-1.2	-1.2	2.8	-1.2	1.0
Average weekly red wine intake	1.4	2.0	3.7	-1.7	-1.7	0.8	-1.9	-0.1
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.7	-0.6	-0.8	-0.0	0.7	0.2
Mood swings	0.8	1.4	5.6	-0.6	-0.7	-2.4	0.4	-0.6
Loneliness, isolation	0.6	0.8	2.1	-0.3	-0.7	-1.0	1.5	0.3
Long-standing illness, disability or infirmity	0.1	0.2	0.8	-0.3	-0.4	0.2	0.9	0.1
Ever had bowel cancer screening	0.5	0.6	1.7	0.0	0.2	0.8	0.7	1.3
Diabetes diagnosed by doctor	1.4	2.3	3.8	-1.8	-1.6	1.9	-1.4	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.1	0.3	0.2	0.3	0.0	-0.3
Friendships satisfaction	0.1	0.2	0.8	0.2	0.0	-0.9	0.1	-0.2
Qualifications: nursing, teaching	0.4	0.6	1.1	0.9	1.0	1.0	-0.4	-0.1
Commuting to job workplace: Walk	2.6	2.8	10.2	-0.1	-0.3	2.0	-3.2	-0.1
Eye problems/disorders: Cataract	0.8	1.0	2.2	-1.4	-1.5	0.3	-0.1	0.8
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.2	-0.3	-0.6	-0.7	-0.6	-1.1
Medication for cholesterol	0.7	1.1	2.7	-0.3	-0.0	1.5	-1.6	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.9	-0.6	-1.0	-0.9	0.2	-0.3
Back pain experienced in last month	2.2	3.1	5.1	2.0	1.8	-1.6	0.9	-2.3
Mineral and other dietary supplements	1.2	1.6	4.2	-0.8	-1.0	2.0	-1.3	0.4
Breast cancer (self-reported)	0.7	0.9	1.9	0.7	0.6	-1.2	0.4	-1.4
Asthma (self-reported)	1.4	2.9	6.7	1.4	1.2	-1.6	2.6	-1.2
Osteoporosis (self-reported)	0.2	0.2	0.4	-0.5	-0.5	0.1	0.7	0.1
Osteoarthritis (self-reported)	0.3	0.4	1.4	-0.4	-0.4	-0.2	0.5	-1.2
Medication: Aspirin	0.2	0.3	1.0	-0.2	0.0	-0.5	0.5	1.0
Medication: Gliclazide	1.0	1.1	2.5	-1.6	-1.0	-1.0	1.0	0.4
Illnesses of father: None of the above (group 1)	2.9	3.6	8.9	-1.8	-2.0	1.4	-3.0	0.1
Smoking status: Current	0.8	1.3	2.4	-1.2	-1.3	1.6	-0.7	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.5	0.1	-0.1	-0.7	0.7	0.4
Whole body water mass	1.1	6.2	10.5	3.2	3.1	-1.1	-1.1	-2.8
Leg predicted mass (right)	1.2	6.6	11.2	3.3	3.1	-0.7	-1.3	-3.1
Arm fat mass (left)	0.2	0.8	2.8	0.0	-0.0	1.7	-1.0	-0.2
Number of self-reported non-cancer illnesses	2.2	3.9	12.5	1.2	1.3	-1.8	3.5	-0.3
Average weekly champagne plus white wine intake	1.2	1.6	2.4	-1.5	-1.3	1.0	-1.6	0.8
Miserableness	0.7	1.2	1.6	-1.3	-1.3	-1.0	-0.8	-1.2
Guilty feelings	1.6	2.4	6.2	1.1	0.7	-2.5	2.0	-0.4
Wears glasses or contact lenses	1.4	1.6	3.5	-1.5	-1.9	1.3	0.4	0.3
Ever taken oral contraceptive pill	0.3	0.4	0.7	-0.8	-0.8	0.3	-0.7	0.2
Hearing aid user	0.7	0.8	2.4	0.5	0.3	-1.1	0.1	-1.5
Mother’s age at death	0.4	0.5	1.3	-1.2	-0.9	-0.2	-0.5	0.5
Financial situation satisfaction	0.2	0.2	0.5	0.3	0.1	0.2	-0.6	-0.7
Tinnitus: Yes, now most or all of the time	0.5	0.5	2.2	-0.3	-0.3	-0.5	1.5	0.3
Commuting to job workplace: Public transport	2.8	3.3	6.0	-1.8	-2.2	1.6	-2.5	-0.2
Eye problems/disorders: Glaucoma	0.6	0.7	1.2	1.1	0.9	0.5	0.4	1.1
Medication: Blood pressure	1.6	3.1	9.5	0.6	0.5	-1.0	3.1	2.1
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.2	-0.7	-0.6	-0.3	0.7	-1.1
Supplements: Fish oil (including cod liver oil)	1.4	1.9	3.8	1.2	1.2	-2.0	1.3	-1.0
High cholesterol (Self-reported)	0.2	0.4	1.8	-0.4	-0.3	0.1	-0.2	-1.4
Medication: Bendroflumethiazide	1.0	1.5	4.5	0.9	1.1	-0.4	2.1	1.0
Medication: Paracetamol	0.2	0.3	0.8	0.1	-0.4	-0.7	-0.4	-0.9
Medication: Lisinopril	0.2	0.3	1.0	0.4	0.2	-0.6	1.0	0.1
Medication: Atorvastatin	0.5	0.6	1.5	-1.1	-1.2	0.5	-0.3	-0.4
Illnesses of father: High blood pressure	2.4	3.0	7.0	1.3	1.4	-0.7	2.6	1.9
Alcohol drinker status: Never	0.9	1.1	2.1	-0.9	-1.3	1.5	-0.2	0.9
Ever smoked	1.2	2.1	7.1	-0.3	-0.3	0.1	1.7	2.7
Basal metabolic rate	0.9	5.2	8.8	3.0	2.9	-0.7	-1.0	-2.8
Leg fat percentage (left)	0.7	2.4	6.7	-1.1	-1.2	2.6	0.2	1.6
Arm fat-free mass (left)	0.9	4.7	8.1	2.8	2.9	-0.9	-0.4	-2.5
Number of operations (self-reported)	1.2	1.9	3.8	0.4	0.5	-1.9	1.9	-1.3
Average weekly beer plus cider intake	1.3	1.9	5.2	1.2	1.4	-0.9	-0.2	-2.3
Irritability	0.3	0.4	0.9	-0.8	-0.9	-0.0	-0.8	0.0
Risk taking	0.5	0.7	2.7	0.2	0.1	0.6	-0.6	1.6
Ever had prostate specific antigen (PSA) test	1.1	1.2	2.9	-0.6	-0.1	1.7	-0.3	1.7
Fractured/broken bones in last 5 years	0.2	0.3	1.2	0.1	-0.2	0.3	1.1	-0.4
Age started oral contraceptive pill	0.7	0.9	2.0	-1.4	-1.3	-0.5	0.1	0.8
Diastolic blood pressure, automated reading	0.7	2.3	8.6	0.4	0.5	1.2	1.1	2.9
Ever depressed for a whole week	3.1	3.8	5.8	-2.4	-2.3	1.2	-2.1	1.5
Unable to work because of sickness or disability	0.3	0.3	0.8	0.1	-0.4	-0.2	0.8	-0.9
Commuting to job workplace: Cycle	0.7	0.9	2.6	0.7	0.3	-1.0	-0.5	-1.6
Myopia	2.7	3.9	5.7	-2.4	-2.1	2.0	-0.7	2.2
Vascular/heart problems diagnosed by doctor	0.6	1.6	4.1	-0.2	-0.2	0.1	-2.0	-2.0
Cholesterol lowering medication	0.2	0.3	0.5	-0.6	-0.7	-0.1	0.6	0.2
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	1.3	-1.0	-1.0	-1.1	-0.7	-1.1
Pain experienced in last month	3.2	5.3	8.0	-2.5	-2.2	2.8	-1.5	2.2
Supplements: Calcium	3.0	3.3	8.6	1.5	1.3	-2.9	1.6	-1.2
Basal cell carcinoma (self-reported)	2.5	3.0	6.0	2.3	2.4	-1.2	1.4	-0.5
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.8	-0.9	-0.9	-0.1	0.6	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.6	-0.6	-0.6	1.3	-0.1	1.2
Heart disease (siblings)	1.5	1.8	3.8	-0.9	-0.4	1.9	-1.6	1.3
Alcohol drinker status: Previous	0.8	0.9	1.6	-1.3	-1.2	0.8	-0.8	0.5
Pack years of smoking	0.7	1.0	3.7	-0.4	-0.7	0.1	0.7	1.9
Impedance of whole body	0.1	0.4	1.0	-0.7	-1.0	-0.1	-0.4	-0.5
Leg fat mass (left)	0.2	0.7	3.3	0.1	-0.0	1.8	-0.4	0.2
Arm predicted mass (left)	0.9	4.5	8.1	2.9	2.8	-1.0	-0.4	-2.3