Best TWAS P=5.95e-38 · Best GWAS P=1.76e-30 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | PLA2R1 | 0.09 | 0.03 | enet | 24 | 0.03 | 1.0e-03 | -4.3 | 10.0 | 9.2e-24 | 0.20 | 0.68 | 0.09 | FALSE |
2 | GTEx | Adipose Subcutaneous | AC009506.1 | 0.07 | 0.05 | lasso | 3 | 0.03 | 1.8e-03 | 7.7 | -7.4 | 1.6e-13 | -0.42 | 0.60 | 0.02 | TRUE |
3 | GTEx | Artery Tibial | PLA2R1 | 0.15 | 0.02 | lasso | 4 | 0.03 | 2.0e-03 | 5.8 | 5.5 | 4.2e-08 | -0.07 | 0.78 | 0.02 | FALSE |
4 | GTEx | Artery Tibial | AC009506.1 | 0.11 | 0.11 | lasso | 4 | 0.10 | 5.5e-08 | 6.2 | -6.2 | 5.4e-10 | -0.40 | 1.00 | 0.00 | TRUE |
5 | GTEx | Brain Hippocampus | LY75 | 0.23 | 0.10 | enet | 13 | 0.06 | 1.8e-02 | -5.7 | 6.0 | 1.5e-09 | -0.11 | 0.10 | 0.05 | TRUE |
6 | GTEx | Cells Transformed fibroblasts | PLA2R1 | 0.26 | 0.16 | enet | 24 | 0.17 | 1.4e-12 | 7.7 | 9.1 | 1.1e-19 | -0.01 | 1.00 | 0.00 | FALSE |
7 | GTEx | Colon Sigmoid | PLA2R1 | 0.19 | 0.15 | lasso | 2 | 0.14 | 1.2e-05 | 7.6 | 7.1 | 1.1e-12 | 0.08 | 0.58 | 0.02 | FALSE |
8 | GTEx | Colon Transverse | PLA2R1 | 0.12 | 0.10 | lasso | 2 | 0.07 | 2.9e-04 | -7.0 | 7.0 | 2.2e-12 | 0.06 | 0.34 | 0.03 | FALSE |
9 | GTEx | Esophagus Mucosa | PLA2R1 | 0.25 | 0.18 | lasso | 5 | 0.27 | 2.0e-18 | 7.7 | 8.0 | 1.3e-15 | 0.05 | 1.00 | 0.00 | FALSE |
10 | GTEx | Esophagus Muscularis | BAZ2B | 0.12 | 0.00 | enet | 61 | 0.01 | 6.3e-02 | -1.7 | 5.7 | 1.1e-08 | 0.06 | 0.12 | 0.06 | TRUE |
11 | GTEx | Esophagus Muscularis | PLA2R1 | 0.07 | 0.07 | enet | 19 | 0.07 | 6.8e-05 | 7.6 | 9.1 | 1.1e-19 | 0.14 | 0.67 | 0.04 | TRUE |
12 | GTEx | Muscle Skeletal | PLA2R1 | 0.04 | 0.03 | enet | 6 | 0.03 | 7.8e-04 | 7.6 | 8.6 | 5.4e-18 | 0.07 | 0.82 | 0.01 | FALSE |
13 | GTEx | Nerve Tibial | PLA2R1 | 0.11 | 0.08 | lasso | 3 | 0.08 | 3.7e-06 | 5.8 | 7.0 | 2.5e-12 | -0.02 | 0.95 | 0.01 | FALSE |
14 | GTEx | Nerve Tibial | AC009506.1 | 0.06 | 0.04 | lasso | 4 | 0.04 | 1.2e-03 | 6.5 | -6.2 | 4.4e-10 | -0.59 | 0.05 | 0.86 | FALSE |
15 | GTEx | Thyroid | MARCH7 | 0.06 | 0.01 | lasso | 15 | 0.01 | 7.8e-02 | -3.0 | -7.7 | 1.6e-14 | -0.48 | 0.29 | 0.38 | FALSE |
16 | GTEx | Vagina | PLA2R1 | 0.20 | -0.01 | enet | 15 | 0.03 | 8.2e-02 | -4.3 | 11.9 | 1.1e-32 | 0.21 | 0.06 | 0.40 | TRUE |
17 | GTEx | Whole Blood | AC009506.1 | 0.13 | 0.02 | enet | 37 | 0.05 | 4.3e-05 | -8.2 | 11.0 | 2.7e-28 | 0.36 | 0.57 | 0.24 | FALSE |
18 | NTR | Blood | BAZ2B | 0.05 | 0.05 | lasso | 6 | 0.05 | 5.1e-16 | 9.9 | 10.7 | 1.5e-26 | 0.56 | 0.79 | 0.21 | TRUE |
19 | YFS | Blood | BAZ2B | 0.23 | 0.26 | enet | 36 | 0.34 | 3.0e-118 | 10.9 | 12.9 | 5.9e-38 | 0.43 | 0.41 | 0.59 | TRUE |
20 | YFS | Blood | CD302 | 0.09 | 0.03 | lasso | 7 | 0.07 | 6.7e-21 | -4.4 | -7.5 | 6.3e-14 | -0.38 | 1.00 | 0.00 | FALSE |
21 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | CD302 | 0.18 | 0.00 | enet | 11 | 0.02 | 1.2e-02 | -7.3 | -5.4 | 6.1e-08 | 0.25 | 0.02 | 0.10 | FALSE |
22 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PLA2R1 | 0.05 | 0.03 | blup | 127 | 0.04 | 5.3e-09 | -4.3 | 6.7 | 1.7e-11 | 0.08 | 0.02 | 0.98 | FALSE |
23 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PLA2R1 | 0.06 | 0.01 | blup | 124 | 0.00 | 8.4e-02 | 7.6 | 6.6 | 4.8e-11 | -0.10 | 0.01 | 0.95 | FALSE |
24 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PLA2R1 | 0.06 | 0.01 | blup | 121 | 0.01 | 1.5e-02 | 7.6 | 6.5 | 1.2e-10 | 0.05 | 0.01 | 0.94 | FALSE |
25 | The Cancer Genome Atlas | Lung Adenocarcinoma | PLA2R1 | 0.06 | 0.03 | blup | 128 | 0.02 | 5.0e-03 | -4.3 | 7.2 | 6.4e-13 | 0.14 | 0.02 | 0.84 | FALSE |
26 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PLA2R1 | 0.05 | 0.04 | lasso | 5 | 0.03 | 1.0e-04 | 7.6 | 7.6 | 2.5e-14 | 0.05 | 0.01 | 0.99 | FALSE |
27 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | LY75 | 0.14 | 0.13 | blup | 114 | 0.11 | 3.5e-05 | -3.7 | 5.2 | 2.1e-07 | -0.14 | 0.62 | 0.03 | FALSE |
28 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PLA2R1 | 0.24 | 0.07 | enet | 15 | 0.13 | 1.4e-13 | 7.6 | 10.8 | 5.8e-27 | 0.12 | 0.01 | 0.99 | TRUE |
29 | The Cancer Genome Atlas | Thyroid Carcinoma | PLA2R1 | 0.03 | 0.01 | lasso | 2 | 0.01 | 1.5e-02 | -5.2 | 5.8 | 8.4e-09 | -0.05 | 0.06 | 0.35 | FALSE |