Hub : Genes

CD302

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Putamen basal ganglia 0.2060 0.0870 7.2e-03 0.132 NA 0.076 NA 0.091 5.1e-04 NA 7.4e-03 NA 3.6e-03
2 GTEx Breast Mammary Tissue 0.1410 0.0630 5.6e-03 -0.005 NA -0.005 NA -0.005 8.4e-01 NA 6.8e-01 NA 7.3e-01
3 NTR Blood 0.0224 0.0093 2.4e-03 0.018 0.005 0.011 0.013 0.014 1.0e-06 5.3e-03 1.0e-04 2.5e-05 1.2e-05
4 ROSMAP Brain Pre-frontal Cortex 0.1334 0.0441 7.0e-06 0.058 0.055 0.098 0.073 0.055 5.9e-08 1.2e-07 1.4e-12 1.1e-09 1.1e-07
5 YFS Blood 0.0857 0.0196 5.6e-17 0.029 0.063 0.064 0.062 0.067 8.6e-10 9.3e-20 3.3e-20 1.5e-19 6.7e-21
6 TCGA Bladder Urothelial Carcinoma 0.1830 0.0750 2.3e-03 0.003 -0.003 0.017 NA 0.002 1.7e-01 9.1e-01 1.2e-02 NA 2.0e-01
7 TCGA Thyroid Carcinoma 0.0820 0.0410 3.1e-06 0.077 0.055 0.061 NA 0.072 5.6e-08 4.5e-06 1.4e-06 NA 1.7e-07

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.3 0.5 1.5 0.7 0.0 -0.7 -1.2 -0.4 -0.2 -0.8
Bipolar Disorder or Schizophrenia 0.8 1.8 5.8 2.2 0.0 0.1 -0.6 -1.0 -0.9 -2.4
Depressed Affect (Nagel 2018) 0.3 0.6 1.4 -0.8 0.0 -0.8 -0.2 -0.3 -1.2 1.2
Depression (Nagel 2018) 0.5 0.7 3.9 0.3 0.0 -0.0 -0.6 -0.6 -2.0 -0.2
Intelligence (Savage-Jansen 2018) 0.3 0.9 2.4 0.6 0.0 -1.4 -0.8 -0.3 1.5 -0.9
Neuroticism (Nagel 2018) 0.2 0.4 1.6 -0.0 0.0 -0.5 0.1 -0.8 -1.3 0.1
Schizophrenia (2018) 0.9 2.0 5.9 2.2 0.0 0.8 0.5 -1.0 -1.0 -2.4
Schizophrenia vs Biploar Disorder 0.3 0.4 1.1 0.8 0.0 1.1 0.1 -0.0 0.1 -0.9
Worry (Nagel 2018) 0.3 0.6 1.6 1.1 0.0 0.5 0.7 -0.5 -0.3 -1.3
Alzheimer’s Disease (in mother) 0.1 0.1 0.3 -0.6 0.0 0.2 0.5 0.3 -0.1 0.0
Alzheimer’s Disease (in father) 2.3 2.5 4.9 1.8 0.0 -1.1 -2.0 -2.2 -0.2 -1.9
Alzheimer’s Disease (including proxy) 1.0 1.5 5.1 1.7 0.0 -0.2 -0.8 -1.3 0.0 -2.3
Crohns Disease (2017) 0.2 0.4 2.1 0.2 0.0 -0.7 -0.3 -0.6 1.4 -0.0
Irritable Bowel Disease (IBD) 0.5 1.2 3.2 1.8 0.0 -0.1 -0.6 -0.8 1.1 -1.6
Ulcerative Colitis (UC) 0.9 1.6 4.9 2.2 0.0 0.0 -1.1 -0.9 0.0 -2.1
Major Depression (MDD) 0.3 0.4 1.0 -0.6 0.0 -1.0 -0.9 -0.5 -0.1 0.4
Reaction Time 0.8 1.4 4.1 1.4 0.0 2.0 0.3 1.1 -0.4 -1.5
Verbal and Numeric Reasoning (VNR) 0.6 1.5 4.8 1.1 0.0 -1.0 -0.2 -1.3 2.2 -1.4
Breast Cancer 0.2 0.4 1.4 -0.4 0.0 -1.2 -0.3 -0.7 0.4 0.6
Ovarian Cancer 0.7 0.9 2.9 1.7 0.0 -0.5 -0.6 -0.2 -0.6 -1.5
Prostate Cancer 0.8 1.2 4.0 -1.5 0.0 -0.4 0.4 2.0 0.6 1.1
Age at First Birth 0.4 0.5 0.9 0.6 0.0 0.8 0.9 0.9 0.8 -0.7
Bipolar Disorder (2011) 2.4 2.3 7.3 -1.3 0.0 -2.7 -1.3 -1.5 -1.4 1.3
Body Mass Index (BMI) (2010) 1.0 1.4 4.1 -1.6 0.0 0.1 1.3 1.0 -0.5 2.0
Coronary Artery Disease (CAD) 1.2 1.4 3.9 1.5 0.0 0.4 0.7 -0.3 2.0 -1.8
Crohns Disease (2012) 0.9 1.5 3.7 -1.1 0.0 -1.9 -1.4 -1.0 1.5 0.7
Mean Putamen Volume 1.1 1.3 2.7 -1.6 0.0 0.4 1.2 1.4 -0.6 1.5
Fasting Glucose 0.0 0.0 0.1 -0.1 0.0 0.1 -0.3 0.1 -0.2 0.2
HbA1C 0.7 0.7 1.8 0.8 0.0 1.2 0.3 0.3 1.1 -1.3
HDL Cholesterol 0.1 0.1 0.4 -0.2 0.0 -0.2 -0.4 -0.6 -0.0 -0.4
LDL Cholesterol 0.2 0.3 1.0 -0.6 0.0 -0.6 -1.0 -0.1 -0.6 0.5
Lupus 0.8 1.2 3.1 1.0 0.0 1.8 1.1 0.6 -0.9 -1.3
Neuroticism (2016) 1.1 1.5 5.1 -0.4 0.0 -1.1 -0.8 -1.8 -2.3 0.7
Primary Biliary Cirrhosis 0.1 0.2 0.6 0.3 0.0 -0.3 -0.7 0.4 0.5 -0.4
Rheumatoid Arthritis 0.5 0.7 2.3 -0.0 0.0 1.1 1.0 1.5 0.8 -0.1
Schizophrenia (2014) 1.6 3.5 10.8 2.9 0.0 0.3 -0.9 -1.5 -1.3 -3.3
Triglycerides 0.5 0.9 4.6 -0.2 0.0 -0.5 -0.7 -0.6 -2.1 0.7
Type 2 Diabetes (T2D) (2012) 0.4 0.4 1.4 0.8 0.0 0.5 0.9 -0.2 0.3 -1.2
Ulcerative Colitis 1.2 1.8 6.4 2.0 0.0 -0.1 -1.4 -0.6 -0.0 -2.5
Blood Eosinophil Count 0.5 3.8 12.2 -0.6 0.0 2.5 3.5 2.2 -1.3 1.1
Blood Platelet Count 0.7 8.2 17.5 3.8 0.0 -4.2 -3.0 -3.4 -0.1 -2.3
Blood Red Count 0.2 2.0 7.2 2.7 0.0 1.5 -0.3 0.7 -0.7 -1.8
Blood White Count 2.7 19.9 56.2 3.9 0.0 -5.0 -2.3 -7.5 -5.4 -2.9
Heel T-Score 0.2 1.5 5.2 -0.6 0.0 1.6 -0.1 2.3 1.5 0.5
BMI 0.5 3.2 9.7 -2.4 0.0 -0.4 2.1 1.3 -0.8 3.1
Height 0.3 6.4 19.1 1.8 0.0 4.4 2.9 2.7 1.4 -2.4
Waist Hip Ratio (WHR) 1.2 5.5 11.9 3.5 0.0 -2.1 -1.7 -3.3 -1.0 -2.7
Systolic Blood Pressure 0.6 3.2 11.8 1.3 0.0 -1.2 -2.0 -1.6 -3.4 -0.7
Smoking Status 2.5 6.0 14.9 -2.3 0.0 -3.9 -1.8 -2.1 -2.6 2.7
Allergy or Eczema 0.6 1.6 4.7 0.2 0.0 -1.2 -1.6 -2.2 -1.4 -0.1
Cardiovascular Disease 0.3 1.1 6.1 1.2 0.0 0.3 0.1 0.1 -2.5 -0.5
Hypothyroidism (self reported) 1.2 2.7 8.0 2.8 0.0 0.2 -0.0 -1.7 -0.6 -2.8
Respiratory disease 0.7 1.5 5.0 0.6 0.0 -1.7 -1.0 -1.2 -2.2 -0.3
Type 2 Diabetes (T2D) (2018) 0.2 0.3 1.0 0.2 0.0 -1.0 -0.4 -0.8 -0.4 0.3
Lung FEV1/FVC ratio 1.3 6.8 21.9 -4.4 0.0 -2.0 -0.4 1.4 0.7 4.7
Lung FVC 0.7 3.6 14.4 2.9 0.0 0.1 -0.9 -1.2 0.7 -3.8
Neuroticism 0.1 0.3 0.9 -0.1 0.0 -0.2 0.8 -0.6 -0.9 0.5
Chronotype (morning person) 0.3 0.8 1.8 0.6 0.0 -1.1 -0.9 -1.4 -1.1 -0.2
Hair Pigment 0.0 0.4 1.2 0.7 0.0 0.6 -0.1 -0.1 0.6 -1.1
Tanning 0.0 0.3 1.1 -1.1 0.0 -0.3 0.5 -0.2 0.1 0.7
Hand grip strength (left) 0.6 1.6 5.6 -2.4 0.0 -0.6 0.6 0.5 -0.8 2.0
Number of treatments/medications taken 0.4 0.7 2.5 1.4 0.0 0.4 0.4 0.1 -0.5 -1.6
Average weekly spirits intake 2.0 2.5 5.9 -2.4 0.0 0.3 1.7 1.5 -0.5 2.4
Sensitivity / hurt feelings 0.3 0.5 2.2 -0.1 0.0 -0.6 -0.3 -1.5 -0.9 -0.4
Frequency of depressed mood in last 2 weeks 0.9 1.2 6.6 0.5 0.0 -0.5 -0.6 -1.0 -2.6 0.0
Hearing difficulty/problems: Yes 0.3 0.4 1.7 0.1 0.0 0.7 1.3 -0.5 0.1 -0.5
Relative age of first facial hair 0.6 1.2 5.7 -1.2 0.0 -0.5 0.4 -0.5 2.4 0.9
Other serious medical condition/disability diagnosed by doctor 0.9 1.1 3.8 1.6 0.0 0.0 -0.7 -1.1 0.2 -2.0
Ever used hormone-replacement therapy (HRT) 0.9 1.2 3.7 0.5 0.0 1.2 1.9 0.3 1.7 -0.1
Ever had hysterectomy (womb removed) 1.0 1.1 3.0 0.5 0.0 1.7 1.6 0.7 -1.3 -0.2
Systolic blood pressure, automated reading 1.0 3.0 8.6 -0.9 0.0 -2.5 -0.9 -1.8 -2.9 1.3
Eye problems/disorders: Diabetes related eye disease 0.4 0.5 1.3 0.1 0.0 -0.8 0.1 -1.2 -1.1 -0.4
Angina 0.3 0.4 1.9 0.0 0.0 0.4 0.9 0.3 -1.4 -0.0
Medication for hormone replacement therapy 3.0 3.4 8.6 0.9 0.0 2.1 2.7 1.1 2.9 -1.2
Vitamin and mineral supplements 0.0 0.1 0.2 -0.4 0.0 0.3 0.1 0.3 0.3 0.1
Supplements: Zinc 0.9 1.0 3.2 -0.9 0.0 1.1 0.5 0.9 1.8 0.6
Medication: Co-codamol 0.6 0.7 2.4 -1.1 0.0 -0.5 0.1 0.1 -0.8 1.5
Medication: Metformin 0.4 0.6 2.7 0.2 0.0 0.3 1.0 0.1 -1.6 0.3
Diabetes (father) 1.9 2.3 6.7 -2.6 0.0 -1.6 0.1 -0.1 -0.9 2.4
Diabetes (mother) 0.1 0.1 0.2 0.2 0.0 0.3 0.3 -0.0 -0.5 -0.1
Severe depression (siblings) 1.7 1.9 4.8 1.8 0.0 1.7 0.8 -0.2 1.4 -2.2
Pack years adult smoking proportion 1.8 2.8 8.2 -0.9 0.0 -2.9 -2.0 -1.3 -2.0 0.9
Impedance of leg (right) 0.4 1.8 3.2 1.8 0.0 -0.5 -1.6 -1.5 1.1 -1.7
Leg fat-free mass (left) 0.7 3.5 7.2 -2.5 0.0 1.1 2.7 2.1 -0.8 2.3
Trunk fat percentage 0.5 1.9 5.4 -1.7 0.0 -0.5 2.1 0.6 -0.3 2.3
Hand grip strength (right) 0.6 1.6 5.2 -2.3 0.0 -0.1 0.5 1.1 -0.9 1.9
Townsend deprivation index at recruitment 0.7 0.9 5.1 -0.2 0.0 -0.4 -0.7 -0.4 -2.3 0.7
Current tobacco smoking 2.7 4.4 11.7 -2.0 0.0 -3.4 -1.3 -1.9 -2.1 2.2
Average weekly fortified wine intake 1.0 1.2 3.4 -0.7 0.0 1.1 1.9 1.1 1.2 0.9
Maternal smoking around birth 0.5 0.8 2.2 1.1 0.0 -1.2 -0.3 -1.5 0.2 -0.6
Fed-up feelings 0.3 0.6 2.8 -0.2 0.0 -0.4 -0.5 -0.6 -1.7 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 3.7 -0.4 0.0 -0.4 -1.1 -0.8 -1.9 0.4
Relative age voice broke 0.8 1.2 5.3 -0.0 0.0 -1.0 -0.9 -1.1 2.3 -0.2
Taking other prescription medications 0.7 1.0 4.0 1.2 0.0 0.6 0.6 0.7 -2.0 -0.8
Age when periods started (menarche) 1.1 2.7 8.1 0.8 0.0 -2.8 -1.3 -2.7 0.8 -0.8
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 1.5 0.6 0.0 0.9 1.2 1.1 -1.2 -0.9
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 2.5 1.2 0.0 1.0 -0.5 0.4 1.6 -1.1
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.8 0.1 0.0 0.9 0.4 0.5 -0.1 -0.2
Qualifications: CSEs or equivalent 0.1 0.1 0.5 -0.2 0.0 -0.1 0.6 0.2 0.7 0.3
Serious illness, injury or assault to yourself 0.1 0.1 0.4 -0.1 0.0 0.7 0.3 0.1 -0.1 0.1
High blood pressure 0.5 1.4 7.7 1.1 0.0 0.2 0.1 -0.4 -2.8 -0.7
Hayfever, allergic rhinitis or eczema 1.0 2.1 5.6 -0.1 0.0 -1.7 -2.1 -2.4 -1.4 0.3
Multivitamins +/- minerals 0.1 0.1 0.5 0.5 0.0 -0.1 -0.0 -0.7 -0.1 0.2
Stomach or abdominal pain in last month 0.8 1.0 3.4 0.8 0.0 -1.1 -1.8 -0.9 -0.4 -0.9
Supplements: Glucosamine 0.6 0.8 4.1 -0.8 0.0 -0.3 0.7 0.3 2.0 0.5
Diverticular disease/diverticulitis (self-reported) 0.4 0.4 1.7 0.5 0.0 -0.8 -1.3 -0.1 -0.1 -0.8
Medication: Atenolol 1.2 1.5 2.9 1.6 0.0 -0.9 -1.4 -1.7 -1.0 -1.0
Medication: Levothyroxine sodium 2.4 4.1 13.4 3.3 0.0 0.2 -1.0 -1.6 -0.8 -3.7
Sitting height 0.4 3.1 8.4 0.0 0.0 2.9 1.8 2.5 1.9 -0.5
Chronic bronchitis/emphysema (father) 1.9 2.2 5.5 2.3 0.0 -0.2 -0.6 -1.9 -0.7 -2.3
High blood pressure (mother) 1.3 1.8 4.2 -1.8 0.0 -1.0 -0.3 0.6 -2.1 2.0
Body mass index (BMI) 1.0 4.1 12.3 -2.9 0.0 -1.0 2.1 0.9 -1.5 3.5
Impedance of leg (left) 0.5 2.2 4.6 2.1 0.0 -0.5 -1.3 -1.6 1.6 -1.9
Leg predicted mass (left) 0.7 3.5 7.1 -2.5 0.0 1.0 2.7 2.0 -0.9 2.3
Trunk fat mass 0.6 2.5 6.7 -1.9 0.0 0.0 2.6 1.1 -0.2 2.5
Waist circumference 0.3 1.2 5.4 -0.6 0.0 -0.2 2.3 0.3 -0.8 1.2
Number of incorrect matches in round 0.8 1.3 4.1 -0.4 0.0 2.0 1.3 1.4 0.6 0.9
Past tobacco smoking 0.3 0.6 1.5 0.6 0.0 1.2 0.6 1.2 0.7 -0.5
Alcohol usually taken with meals 0.2 0.4 1.1 0.7 0.0 0.7 0.6 -0.0 -1.0 -0.5
Nervous feelings 0.1 0.2 0.9 -0.1 0.0 0.2 0.1 -0.1 -1.0 -0.2
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.3 -0.6 0.0 0.4 0.2 0.5 -0.6 0.4
Hearing difficulty/problems with background noise 1.4 2.2 6.4 2.4 0.0 0.9 0.7 -0.8 1.2 -2.5
Hair/balding pattern: Pattern 2 0.5 0.6 2.0 -0.2 0.0 1.0 1.4 0.4 0.2 1.0
Had menopause 1.9 2.4 4.5 -1.6 0.0 1.5 1.6 1.8 2.1 1.3
Had other major operations 0.5 0.6 2.4 0.4 0.0 -0.6 -1.1 -0.5 -1.5 -0.3
Forced vital capacity (FVC) 0.8 2.9 10.0 2.6 0.0 0.2 -0.5 -1.2 1.3 -3.2
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.4 5.9 1.3 0.0 0.7 -0.3 0.1 2.4 -1.2
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.4 -0.8 0.0 -1.0 -0.8 -1.2 0.1 0.8
Qualifications: None of the above 0.6 1.2 7.7 0.3 0.0 -0.5 0.1 0.0 -2.8 0.5
Financial difficulties in last 2 years 0.4 0.6 1.7 -0.1 0.0 -1.3 -0.7 -1.0 -0.8 -0.0
Mouth/teeth dental problems 0.7 1.0 2.9 -1.7 0.0 -0.4 -0.5 1.1 0.1 1.7
Heart attack 0.2 0.2 0.5 0.7 0.0 0.3 0.0 0.6 -0.7 0.4
Allergy 0.6 1.4 3.3 -0.1 0.0 1.3 1.8 1.3 1.8 -0.2
Pain all over the body in last month 0.6 0.7 1.9 1.4 0.0 0.9 0.4 -0.3 -0.3 -1.2
Diabetes (self-reported) 0.0 0.0 0.1 0.3 0.0 -0.3 -0.0 0.2 -0.3 0.1
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 2.1 -1.2 0.0 0.4 -0.5 1.0 0.6 1.4
Medication: Ramipril 0.2 0.2 1.1 0.3 0.0 0.1 -0.0 0.5 -1.1 -0.1
Medication: Simvastatin 0.7 1.1 4.5 1.4 0.0 0.2 -0.5 -0.3 -2.1 -0.8
Fluid intelligence score 0.5 1.1 5.6 0.5 0.0 0.6 0.8 0.9 2.4 -0.3
Illnesses of siblings 0.2 0.4 1.8 0.2 0.0 0.6 -0.2 0.4 1.3 0.1
Neuroticism score 0.2 0.4 1.5 0.2 0.0 -0.5 0.0 -1.2 -1.0 -0.0
Weight 0.7 3.6 9.0 -2.3 0.0 0.8 3.0 1.8 -0.6 2.6
Impedance of arm (right) 0.3 1.4 3.2 1.5 0.0 -0.6 -1.8 -1.1 0.6 -1.6
Arm fat percentage (right) 0.7 2.8 9.7 -2.3 0.0 -1.6 1.0 0.5 -0.9 3.1
Trunk fat-free mass 0.6 3.4 7.4 -2.0 0.0 1.9 2.7 2.4 -0.5 1.6
Hip circumference 1.0 4.5 11.2 -2.8 0.0 0.8 3.4 1.7 -0.5 2.9
Time employed in main current job 0.4 0.5 1.1 0.7 0.0 0.8 -0.6 0.1 0.8 -1.0
Alcohol intake versus 10 years previously 2.0 3.0 9.9 3.1 0.0 0.1 0.1 -1.3 0.8 -2.9
Father’s age at death 0.2 0.2 0.4 -0.5 0.0 -0.5 0.6 -0.6 -0.6 0.3
Worrier / anxious feelings 0.0 0.1 0.3 0.5 0.0 0.2 -0.2 -0.3 0.2 -0.4
Frequency of tiredness / lethargy in last 2 weeks 1.7 2.8 10.8 1.5 0.0 -0.7 -1.1 -2.0 -3.3 -0.8
Falls in the last year 0.9 1.2 3.6 1.9 0.0 -0.2 -0.5 -1.6 -0.8 -1.0
Hair/balding pattern: Pattern 3 0.5 0.8 2.5 -1.6 0.0 -0.9 -0.4 0.0 -0.4 1.3
Number of live births 1.8 2.5 7.6 -1.5 0.0 -2.8 -0.6 -1.6 -1.0 1.9
Forced expiratory volume in 1-second (FEV1) 0.3 1.1 2.6 1.2 0.0 -0.6 -0.7 -1.3 1.1 -1.6
Pulse rate 1.1 1.8 6.1 -0.0 0.0 -2.5 -1.7 -1.7 -0.8 0.2
Happiness 1.1 1.3 2.7 1.4 0.0 -0.4 -1.1 -1.4 -1.6 -1.2
Noisy workplace 0.4 0.5 0.9 -0.6 0.0 0.9 0.8 1.0 -0.5 0.6
Qualifications: A levels/AS levels or equivalent 0.2 0.4 1.4 -0.2 0.0 -0.2 -1.2 0.3 0.9 -0.1
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 3.0 1.0 0.0 -0.8 -1.1 -1.7 0.3 -0.8
Mouth/teeth dental problems: Dentures 0.7 1.2 3.1 1.6 0.0 -0.3 0.0 -1.6 -0.4 -1.8
Asthma 0.5 1.0 2.8 -0.8 0.0 -1.5 -0.2 -0.2 -1.7 1.2
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.4 3.7 -1.4 0.0 -1.9 -0.5 -1.5 -0.0 1.2
Medication: Cholesterol lowering 0.4 0.6 2.4 1.0 0.0 -0.1 -0.8 -0.4 -1.6 -0.4
Depression (self-reported) 0.8 1.0 3.1 1.3 0.0 1.3 -0.3 -0.2 0.5 -1.8
Medication: Lansoprazole 1.4 1.6 4.4 1.4 0.0 2.1 0.8 1.2 1.0 -1.3
Prospective memory result 0.2 0.2 0.7 0.4 0.0 -0.1 0.5 -0.4 -0.9 0.4
Lung cancer (father) 0.4 0.5 1.2 0.6 0.0 1.1 1.1 0.6 -0.5 -0.4
Illnesses of mother 1.3 1.6 4.6 1.6 0.0 0.1 -0.1 -1.1 1.8 -2.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.3 4.0 1.3 0.0 -0.1 -0.8 -0.6 2.0 -1.6
Pulse wave Arterial Stiffness index 0.3 0.4 1.0 -0.6 0.0 0.5 0.5 0.1 1.0 0.9
Impedance of arm (left) 0.3 1.5 2.6 1.6 0.0 -0.4 -1.6 -1.4 0.8 -1.6
Arm fat mass (right) 0.7 2.9 8.6 -2.3 0.0 -0.5 2.1 1.1 -0.7 2.9
Trunk predicted mass 0.6 3.2 7.0 -1.8 0.0 1.9 2.6 2.4 -0.6 1.6
Standing height 0.5 4.6 15.5 1.0 0.0 3.9 2.7 2.1 1.3 -1.6
Length of working week for main job 1.1 1.2 3.9 -0.4 0.0 1.3 2.0 1.7 0.4 0.3
Exposure to tobacco smoke at home 0.4 0.4 2.2 0.0 0.0 0.8 -0.3 0.3 -1.5 -0.4
Breastfed as a baby 0.7 0.9 2.9 0.4 0.0 1.7 0.8 0.6 1.1 -1.0
Tense / ‘highly strung’ 1.3 2.2 5.4 2.2 0.0 0.3 0.4 -2.1 -0.7 -2.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.7 3.0 0.0 0.0 1.0 1.0 0.5 -1.7 0.1
Hair/balding pattern: Pattern 4 0.3 0.7 2.8 0.3 0.0 0.6 -0.3 0.7 -1.7 -0.8
Birth weight of first child 1.9 3.5 8.5 -0.7 0.0 2.3 1.7 2.9 2.7 0.0
Peak expiratory flow (PEF) 0.6 1.5 5.1 0.0 0.0 -2.1 -1.0 -2.3 -0.0 0.0
Pulse wave reflection index 1.0 1.2 3.3 -0.6 0.0 1.2 1.5 0.9 1.8 0.5
Ever highly irritable/argumentative for 2 days 0.6 0.7 4.5 -0.0 0.0 -0.0 -0.1 -0.7 -2.1 -0.2
Loud music exposure frequency 0.4 0.5 1.2 1.1 0.0 0.9 0.4 -0.5 0.2 -0.9
Qualifications: O levels/GCSEs or equivalent 0.8 1.3 3.4 -0.2 0.0 -1.4 -1.8 -0.5 1.9 -0.2
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.3 0.0 0.0 -0.0 0.4 -0.5 0.6 -0.0
Blood clot in the leg (DVT) 0.4 0.5 1.4 -0.3 0.0 0.3 -0.4 1.2 -1.0 0.7
Medication: Paracetamol 0.6 1.1 1.9 -1.4 0.0 -1.1 -0.7 -0.7 -1.2 1.4
Headache pain in last month 0.6 1.1 2.8 -0.9 0.0 -1.5 -1.1 -1.7 -0.1 0.7
Medication for cholesterol, blood pressure or diabetes 0.9 1.5 6.8 -1.1 0.0 0.5 1.2 0.6 2.6 0.5
Glaucoma (self-reported) 0.2 0.3 0.6 -0.6 0.0 -0.1 -0.3 0.8 -0.4 0.8
Gout (self-reported) 0.7 0.9 2.3 -1.4 0.0 0.4 0.5 0.4 1.2 1.5
Hypothyroidism/myxoedema (self-reported) 1.7 3.4 10.5 3.1 0.0 1.6 0.5 -0.7 -0.1 -3.2
Medication: Amlodipine 0.1 0.1 0.3 -0.2 0.0 0.4 0.5 0.0 0.1 0.2
Medication: Ventolin 100micrograms inhaler 0.5 0.6 1.7 0.6 0.0 0.0 0.2 -0.7 -1.2 -1.3
Birth weight 1.2 2.6 6.3 -2.5 0.0 0.1 -0.6 2.5 1.4 1.8
Chronic bronchitis/emphysema (mother) 1.5 1.7 4.5 1.3 0.0 -0.8 -0.6 -1.9 -2.1 -1.2
High blood pressure (siblings) 2.0 2.9 16.6 -0.8 0.0 -0.9 -0.4 -1.2 -4.1 0.7
Forced vital capacity (FVC), Best measure 0.6 2.1 6.8 2.0 0.0 0.5 -0.6 -0.6 1.9 -2.6
Body fat percentage 0.6 2.2 7.2 -2.0 0.0 -1.1 1.7 0.3 -0.3 2.7
Leg fat percentage (right) 0.8 2.8 9.1 -2.3 0.0 -1.8 1.0 -0.2 -0.8 3.0
Arm fat-free mass (right) 0.9 4.5 10.2 -2.5 0.0 1.7 3.2 2.5 0.0 2.4
Exposure to tobacco smoke outside home 0.3 0.4 1.2 -0.1 0.0 -0.9 -0.2 -1.1 -0.8 0.0
Comparative body size at age 10 0.9 2.6 5.5 -2.3 0.0 0.9 1.4 2.0 1.1 2.1
Number of full brothers 0.6 0.7 1.6 1.0 0.0 -0.7 -0.5 -1.3 -1.1 -0.6
Worry too long after embarrassment 0.5 0.8 3.6 -0.2 0.0 1.2 1.9 0.5 -0.2 0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.1 1.4 4.7 1.9 0.0 0.3 -0.3 -0.6 -1.1 -2.2
Wheeze or whistling in the chest in last year 1.4 2.4 6.2 -0.9 0.0 -2.5 -0.7 -1.4 -2.5 1.2
Number of children fathered 0.4 0.4 2.3 -0.2 0.0 0.6 1.5 0.1 -0.3 -0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.9 1.4 0.0 0.4 0.1 -0.7 0.9 -1.1
Age at first live birth 0.4 0.6 1.9 -1.4 0.0 0.1 -1.0 0.8 -0.1 0.9
Pulse wave peak to peak time 0.3 0.3 1.0 0.8 0.0 -0.1 -0.2 0.1 -0.9 -1.0
Health satisfaction 1.2 1.5 4.2 -0.4 0.0 -1.6 -2.1 -1.3 -0.9 1.0
Shortness of breath walking on level ground 1.1 1.4 3.5 -0.2 0.0 -1.8 -1.1 -1.9 -0.8 0.8
Qualifications: College or University degree 0.7 2.3 7.1 1.0 0.0 2.7 1.6 1.3 1.4 -1.4
Eye problems/disorders: None of the above 1.0 1.2 4.8 0.4 0.0 1.3 1.0 2.2 0.5 0.2
Mouth/teeth dental problems: Loose teeth 0.8 0.9 2.8 -1.7 0.0 -1.3 -0.5 0.2 -0.1 1.3
Emphysema/chronic bronchitis 0.3 0.3 1.0 1.0 0.0 -0.1 0.0 -0.2 -0.5 -0.8
Medication for pain relief, constipation, heartburn 0.4 0.7 1.4 -0.2 0.0 1.2 0.9 1.2 1.1 -0.2
Neck or shoulder pain in last month 0.9 1.2 4.5 0.3 0.0 -1.5 -1.2 -2.1 -0.6 -0.1
Medication: Blood pressure 0.6 1.1 4.7 0.5 0.0 -1.0 -1.1 -0.7 -2.2 0.0
Angina (self-reported) 0.3 0.5 1.5 0.1 0.0 0.7 1.0 0.5 -1.2 -0.1
Migraine (self-reported) 0.8 0.9 1.8 -1.2 0.0 -1.0 0.2 -1.4 -1.3 0.8
Medication: Ibuprofen 0.6 0.7 1.6 -1.2 0.0 -1.1 0.4 -0.9 0.1 1.1
Medication: Allopurinol 1.3 1.8 6.0 -2.2 0.0 -0.7 -0.2 0.3 1.0 2.4
Medication: Omeprazole 0.6 0.7 3.3 -0.5 0.0 -1.8 -0.6 -0.6 -0.4 0.6
Medication: Seretide 50 evohaler 0.4 0.5 1.1 0.0 0.0 0.8 -1.0 0.9 1.0 -0.2
Mean time to correctly identify matches 1.1 2.1 5.9 1.5 0.0 2.4 1.0 1.6 0.4 -1.6
Heart disease (mother) 0.6 0.7 2.0 -0.7 0.0 -0.4 -0.6 0.7 -1.2 1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.5 -0.8 0.0 -1.2 -0.9 -0.5 -0.6 0.5
Whole body fat mass 0.6 2.6 6.9 -2.2 0.0 -0.3 2.2 1.0 -0.5 2.6
Leg fat mass (right) 0.7 2.6 8.0 -2.3 0.0 -0.7 2.0 0.6 -0.4 2.8
Arm predicted mass (right) 0.7 3.8 10.6 -2.0 0.0 1.8 3.3 2.2 -0.1 1.9
Pulse rate, automated reading 1.3 4.3 8.1 1.9 0.0 -2.9 -2.0 -2.8 -2.1 -1.5
Alcohol intake frequency. 1.3 3.0 8.5 2.9 0.0 -0.7 -0.9 -1.9 -0.1 -2.7
Comparative height size at age 10 0.8 4.7 13.6 -0.3 0.0 3.7 3.2 2.9 -0.5 0.2
Number of full sisters 1.9 2.3 9.7 -0.6 0.0 -1.7 -0.8 -1.6 -3.1 0.4
Suffer from ‘nerves’ 0.1 0.1 0.2 -0.4 0.0 0.2 0.4 -0.3 0.3 -0.2
Overall health rating 1.6 3.4 8.3 1.6 0.0 -2.0 -1.9 -2.2 -2.9 -1.0
Chest pain or discomfort 1.0 1.4 7.2 0.9 0.0 -0.2 -0.8 -1.1 -2.7 -0.5
Had major operations 0.8 1.0 2.8 1.4 0.0 -0.8 -0.8 -0.9 0.0 -1.7
Age at last live birth 0.4 0.5 1.6 -1.0 0.0 -0.4 -0.9 -0.3 -0.1 1.2
Family relationship satisfaction 3.9 4.8 11.1 2.6 0.0 -1.8 -2.3 -3.3 -1.9 -1.9
Leg pain on walking 0.6 0.7 2.1 0.4 0.0 -0.6 -1.4 -1.4 -0.0 -0.8
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 2.8 -0.7 0.0 -0.0 0.3 1.1 1.7 0.7
Commuting to job workplace: Car/motor vehicle 0.3 0.3 1.1 0.7 0.0 0.8 0.4 0.3 -0.2 -1.1
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 3.2 0.7 0.0 1.7 0.8 1.8 0.7 -0.9
Medication: Aspirin 0.4 0.5 2.0 0.8 0.0 0.7 -0.4 0.6 -1.4 -0.3
Supplements: Vitamin C 0.2 0.3 0.9 -0.9 0.0 -0.6 -0.7 0.4 0.1 0.2
Knee pain experienced in last month 0.8 1.2 2.9 -1.7 0.0 -1.4 -0.6 -0.9 -0.6 1.5
Hypertension (Self-reported) 0.5 1.5 6.7 1.4 0.0 1.0 0.4 0.3 -2.6 -0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.2 3.9 -2.0 0.0 -0.8 -0.2 1.0 -0.5 1.7
Illnesses of father: Heart disease 1.5 2.0 5.4 0.3 0.0 2.3 2.2 1.3 -1.3 -0.6
Illnesses of siblings: Diabetes 0.5 0.7 1.5 -1.0 0.0 0.0 1.2 0.5 0.7 1.2
Smoking status: Previous 0.0 0.0 0.2 0.1 0.0 0.4 -0.2 -0.1 0.0 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.0 0.1 0.3 0.0 0.0 0.1 -0.2 0.3 -0.6 -0.2
Whole body fat-free mass 0.7 3.7 8.6 -2.2 0.0 1.6 2.9 2.4 -0.6 2.0
Leg fat-free mass (right) 0.7 3.5 8.1 -2.3 0.0 1.3 2.8 2.2 -0.6 2.1
Arm fat percentage (left) 0.7 2.9 10.2 -2.3 0.0 -1.7 1.0 0.2 -0.9 3.2
Average weekly red wine intake 0.4 0.6 2.2 -0.3 0.0 1.1 0.8 0.4 -1.5 0.1
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.6 0.1 0.0 -0.6 0.8 -0.7 0.1 0.0
Mood swings 0.6 1.1 2.6 -1.0 0.0 -1.5 -0.2 -0.7 -1.2 1.6
Loneliness, isolation 0.8 1.0 3.0 0.9 0.0 -0.4 -1.1 -1.7 -0.9 -1.1
Long-standing illness, disability or infirmity 1.0 1.5 3.5 1.9 0.0 -0.7 -0.2 -1.5 -1.2 -1.6
Ever had bowel cancer screening 3.0 3.5 8.2 2.0 0.0 -1.7 -2.1 -2.9 -1.7 -1.5
Diabetes diagnosed by doctor 0.1 0.1 0.4 0.6 0.0 -0.3 0.1 -0.2 -0.4 -0.3
Ever had stillbirth, spontaneous miscarriage or termination 1.4 1.5 5.1 1.6 0.0 -0.3 -0.3 -2.3 -0.6 -1.4
Friendships satisfaction 0.5 0.6 2.3 1.5 0.0 0.2 -0.1 -0.7 -0.3 -1.1
Qualifications: nursing, teaching 0.4 0.6 2.4 -1.6 0.0 0.2 0.3 0.4 0.6 1.1
Commuting to job workplace: Walk 0.6 0.7 2.1 0.7 0.0 -1.0 -0.9 -0.5 -1.5 -0.3
Eye problems/disorders: Cataract 0.5 0.6 1.3 -1.1 0.0 -1.0 0.6 -0.6 0.9 0.8
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 1.5 1.2 0.0 0.9 0.1 0.1 0.8 -0.7
Medication for cholesterol 1.3 2.0 5.1 -1.4 0.0 -2.1 -2.3 -0.9 -0.0 1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.0 2.3 5.1 -1.1 0.0 -2.2 -1.6 -1.7 -1.7 1.1
Back pain experienced in last month 0.3 0.4 1.6 -0.5 0.0 -0.6 -0.2 -0.3 -1.3 0.6
Mineral and other dietary supplements 0.3 0.4 1.3 -0.5 0.0 -0.4 -0.8 -0.1 -1.1 0.8
Breast cancer (self-reported) 0.7 0.8 2.5 0.7 0.0 1.6 0.3 1.5 0.3 -0.7
Asthma (self-reported) 0.6 1.2 2.7 -1.0 0.0 -1.6 -0.3 -0.1 -1.6 1.5
Osteoporosis (self-reported) 0.6 0.8 1.7 1.3 0.0 -1.1 -0.7 -0.6 -0.6 -1.2
Osteoarthritis (self-reported) 0.6 0.7 1.5 -1.2 0.0 -0.8 -0.1 -0.6 -1.2 1.2
Medication: Aspirin 0.4 0.5 1.8 0.6 0.0 0.4 -0.8 0.4 -1.3 -0.3
Medication: Gliclazide 0.1 0.1 0.3 -0.1 0.0 -0.5 -0.0 -0.2 0.1 0.4
Illnesses of father: None of the above (group 1) 1.0 1.3 6.0 -0.6 0.0 -0.8 -0.8 -0.2 2.5 1.1
Smoking status: Current 2.5 3.9 10.0 -2.1 0.0 -3.2 -1.0 -1.6 -2.0 2.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 3.2 1.4 0.0 0.3 -0.1 -0.2 1.4 -1.8
Whole body water mass 0.7 4.0 9.1 -2.3 0.0 1.8 3.0 2.5 -0.5 2.1
Leg predicted mass (right) 0.6 3.4 8.2 -2.2 0.0 1.4 2.9 2.2 -0.6 2.0
Arm fat mass (left) 0.7 3.0 9.3 -2.4 0.0 -0.6 2.0 1.0 -0.7 3.0
Number of self-reported non-cancer illnesses 0.2 0.4 2.3 0.5 0.0 -0.4 -0.2 -0.4 -1.5 -0.3
Average weekly champagne plus white wine intake 0.7 1.0 2.2 -1.5 0.0 -0.5 -0.3 0.9 -1.3 1.4
Miserableness 1.0 1.8 4.0 -1.3 0.0 0.8 2.0 0.3 -1.5 1.9
Guilty feelings 0.7 1.1 3.0 -0.8 0.0 -1.4 0.1 -1.7 -1.0 1.1
Wears glasses or contact lenses 0.1 0.1 0.3 -0.3 0.0 0.4 0.1 0.2 -0.5 0.2
Ever taken oral contraceptive pill 2.9 3.2 9.1 1.6 0.0 -2.3 -1.7 -3.0 -0.3 -1.6
Hearing aid user 1.0 1.1 4.8 -0.5 0.0 0.6 2.2 1.0 -1.0 0.4
Mother’s age at death 3.4 4.2 8.7 -0.9 0.0 2.4 2.8 2.9 2.0 1.4
Financial situation satisfaction 1.6 2.0 3.3 1.7 0.0 -0.4 -1.2 -1.8 -1.6 -1.8
Tinnitus: Yes, now most or all of the time 1.1 1.3 2.8 1.3 0.0 1.7 1.0 1.0 -1.1 -1.1
Commuting to job workplace: Public transport 0.6 0.7 1.6 -0.2 0.0 -1.3 -1.0 -0.8 -0.9 0.7
Eye problems/disorders: Glaucoma 0.3 0.3 0.8 -0.7 0.0 0.5 0.5 0.9 -0.3 0.7
Medication: Blood pressure 0.7 1.4 4.5 0.9 0.0 2.1 1.3 1.6 0.4 -0.5
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.1 1.0 0.0 0.2 0.9 -0.4 1.0 -0.5
Supplements: Fish oil (including cod liver oil) 0.2 0.3 1.3 -0.2 0.0 -1.1 0.4 -0.7 0.3 0.2
High cholesterol (Self-reported) 0.5 0.8 5.0 0.5 0.0 -0.3 0.2 -0.1 -2.2 0.4
Medication: Bendroflumethiazide 0.6 1.0 2.3 1.1 0.0 1.4 0.1 1.5 -0.9 -0.6
Medication: Paracetamol 0.4 0.6 1.5 -1.2 0.0 -0.9 -0.8 -0.3 -0.3 1.1
Medication: Lisinopril 0.3 0.4 1.0 0.8 0.0 0.8 -0.1 0.5 -1.0 -0.5
Medication: Atorvastatin 0.2 0.3 0.7 0.3 0.0 -0.6 0.1 -0.8 -0.7 0.6
Illnesses of father: High blood pressure 0.3 0.4 2.1 0.3 0.0 -0.2 -0.6 -0.0 -1.4 -0.3
Alcohol drinker status: Never 1.6 2.0 6.0 2.3 0.0 -0.2 -0.6 -1.0 -0.9 -2.5
Ever smoked 1.7 3.0 7.5 -1.6 0.0 -2.7 -1.7 -2.2 -1.0 1.5
Basal metabolic rate 0.7 3.8 9.1 -2.3 0.0 1.4 3.0 2.2 -0.6 2.2
Leg fat percentage (left) 0.7 2.6 8.8 -2.2 0.0 -1.7 1.3 -0.0 -0.4 3.0
Arm fat-free mass (left) 0.7 3.8 9.6 -2.1 0.0 1.6 3.1 2.4 -0.1 2.0
Number of operations (self-reported) 0.9 1.3 4.3 -0.6 0.0 -1.4 -1.4 -0.2 -2.1 0.8
Average weekly beer plus cider intake 0.1 0.1 0.3 -0.0 0.0 -0.1 0.5 -0.4 0.0 -0.3
Irritability 0.8 1.4 2.5 1.6 0.0 -1.3 -0.9 -1.6 0.3 -1.5
Risk taking 0.7 1.0 2.3 1.5 0.0 0.7 1.3 -0.6 -1.3 -0.8
Ever had prostate specific antigen (PSA) test 2.2 2.6 7.6 -0.6 0.0 2.0 2.8 1.8 1.6 0.6
Fractured/broken bones in last 5 years 0.6 0.7 2.1 0.4 0.0 -0.9 -0.6 -1.3 -1.4 0.0
Age started oral contraceptive pill 0.4 0.5 1.1 1.1 0.0 -0.1 -0.7 -0.6 0.8 -1.0
Diastolic blood pressure, automated reading 0.5 1.6 4.4 -1.7 0.0 -1.0 0.1 -0.4 -1.7 2.1
Ever depressed for a whole week 0.1 0.2 0.6 -0.7 0.0 0.2 0.2 -0.1 -0.3 0.8
Unable to work because of sickness or disability 3.6 4.6 9.9 2.1 0.0 -1.8 -2.5 -2.4 -3.1 -1.6
Commuting to job workplace: Cycle 1.1 1.3 7.5 -0.6 0.0 -0.2 0.2 -0.8 2.7 0.8
Myopia 0.1 0.1 0.6 0.3 0.0 -0.7 -0.2 -0.1 0.0 -0.2
Vascular/heart problems diagnosed by doctor 0.6 1.6 9.0 -1.2 0.0 0.2 0.3 0.5 3.0 0.7
Cholesterol lowering medication 0.6 0.9 2.3 1.1 0.0 1.1 1.5 0.1 -1.1 -0.4
Medication: Omeprazole (e.g. Zanprol) 0.4 0.4 2.1 -0.1 0.0 -1.5 -0.4 -0.3 -0.8 0.2
Pain experienced in last month 0.4 0.7 1.4 0.2 0.0 1.1 1.1 1.1 1.2 -0.2
Supplements: Calcium 1.1 1.2 2.1 1.1 0.0 -1.0 -1.1 -1.3 -1.4 -1.2
Basal cell carcinoma (self-reported) 0.3 0.3 0.9 0.3 0.0 1.0 0.9 0.4 0.2 -0.4
Heart attack/myocardial infarction (self-reported) 0.2 0.2 0.6 0.8 0.0 0.3 0.1 0.6 -0.6 0.2
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 3.1 -0.7 0.0 0.7 0.0 1.8 -1.0 1.1
Heart disease (siblings) 0.5 0.6 1.1 -1.0 0.0 -0.1 0.7 1.0 1.1 0.4
Alcohol drinker status: Previous 1.6 1.8 5.9 2.0 0.0 0.1 -0.3 -1.6 -0.2 -2.4
Pack years of smoking 1.9 2.8 7.4 -0.6 0.0 -2.7 -2.0 -1.5 -2.2 0.7
Impedance of whole body 0.4 1.9 4.2 2.0 0.0 -0.2 -1.4 -1.3 1.5 -1.9
Leg fat mass (left) 0.7 2.6 7.4 -2.1 0.0 -0.6 2.2 0.8 -0.1 2.7
Arm predicted mass (left) 0.7 3.6 10.0 -1.9 0.0 1.6 3.2 2.3 0.1 1.9