TWAS hub - MARCH7

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Thyroid	0.061	0.027	2.2e-03	0.012	NA	0.003	NA	0.008	0.039	NA	1.8e-01	NA	0.07800
2	YFS	Blood	0.110	0.029	3.1e-08	0.000	0.033	0.032	0.042	0.011	0.420	4e-11	1.2e-10	1.5e-13	0.00013

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Migraine (self-reported)	4.1	5.1	10.2	0.2	-3.2
Blood White Count	4.0	29.5	59.0	-7.7	0.2
Alcohol drinker status: Previous	3.9	4.5	8.3	-2.9	0.8
Lung FEV1/FVC ratio	3.8	19.3	37.3	6.1	-1.1
Schizophrenia (2018)	3.7	7.8	10.9	-2.1	-3.3
Schizophrenia (2014)	3.6	8.0	9.4	-3.1	-2.5
Ulcerative Colitis	3.6	5.2	6.7	-2.6	1.9
Medication: Levothyroxine sodium	3.6	6.1	12.2	-3.5	0.1
Ever had stillbirth, spontaneous miscarriage or termination	3.6	3.8	3.9	-1.9	-2.0
Frequency of tiredness / lethargy in last 2 weeks	3.5	5.8	9.3	-1.5	-3.0
Alcohol drinker status: Never	3.3	3.9	7.7	-2.8	0.3
Had menopause	3.2	4.0	7.5	2.7	-0.8
Smoking Status	3.1	7.3	9.6	2.2	-3.1
Alcohol intake versus 10 years previously	3.1	4.6	8.8	-3.0	0.7
Comparative body size at age 10	3.1	8.4	13.8	3.7	-1.8
Bipolar Disorder or Schizophrenia	3.0	7.3	7.8	-2.6	-2.8
Other serious medical condition/disability diagnosed by doctor	3.0	3.9	7.3	-2.7	0.7
Qualifications: O levels/GCSEs or equivalent	3.0	4.7	9.1	0.6	3.0
Risk taking	3.0	4.4	8.1	-2.8	-0.8
Taking other prescription medications	2.9	4.5	6.9	-2.6	-1.4
Tense / ‘highly strung’	2.9	4.8	5.2	-2.1	-2.3
Blood Platelet Count	2.8	32.4	63.5	-8.0	-1.2
Hearing difficulty/problems with background noise	2.8	4.5	9.0	-3.0	-0.0
Hypothyroidism/myxoedema (self-reported)	2.7	5.3	10.6	-3.2	-0.3
Rheumatoid Arthritis	2.6	3.6	6.9	0.5	-2.6
Past tobacco smoking	2.6	4.8	9.5	0.3	3.1
Hair/balding pattern: Pattern 3	2.6	3.8	3.8	2.0	1.9
Chronic bronchitis/emphysema (father)	2.5	2.9	5.6	-2.4	-0.4
Eye problems/disorders: None of the above	2.5	2.9	5.6	0.4	2.4
Mouth/teeth dental problems: Loose teeth	2.5	2.9	3.2	1.8	1.6
Osteoporosis (self-reported)	2.5	3.0	4.8	-1.1	2.2
Medication: Lisinopril	2.5	3.2	5.2	-1.1	-2.3
Unable to work because of sickness or disability	2.5	3.2	4.3	-2.1	-1.5
Type 2 Diabetes (T2D) (2012)	2.4	2.7	3.2	-1.5	1.8
Diabetes (father)	2.4	2.9	5.1	2.3	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	2.4	3.1	5.7	-2.4	0.7
Ever had bowel cancer screening	2.4	2.8	3.3	-1.8	-1.5
Prostate Cancer	2.3	3.3	5.3	1.1	2.3
Depression (self-reported)	2.3	2.8	4.5	-1.0	-2.1
Worry too long after embarrassment	2.3	3.9	7.8	-0.0	-2.8
Long-standing illness, disability or infirmity	2.3	3.4	6.7	-2.6	-0.5
Ever taken oral contraceptive pill	2.3	2.6	4.8	-2.2	0.6
Financial situation satisfaction	2.2	2.7	3.3	-1.5	-1.8
Heart attack/myocardial infarction (self-reported)	2.2	2.9	4.8	-1.0	-2.2
Alzheimer’s Disease (in father)	2.1	2.3	3.6	-1.0	-1.9
HbA1C	2.1	2.3	4.4	-0.5	2.1
Heart attack	2.1	2.7	4.7	-0.9	-2.2
Ever smoked	2.1	3.6	7.0	0.6	-2.6
Coronary Artery Disease (CAD)	2.0	2.4	3.6	-1.9	1.0
Number of treatments/medications taken	2.0	3.5	6.2	-2.5	-0.9
Birth weight	2.0	4.4	7.8	2.8	1.0
Number of children fathered	2.0	2.3	3.3	-1.1	-1.8
Alcohol intake frequency.	2.0	4.6	8.2	-2.9	1.0
Depression (Nagel 2018)	1.9	2.8	5.1	-0.7	-2.3
Hypothyroidism (self reported)	1.9	4.3	8.4	-2.9	-0.4
Neck or shoulder pain in last month	1.9	2.7	4.5	-1.0	-2.1
Systolic blood pressure, automated reading	1.8	5.3	8.4	1.5	-2.9
Severe depression (siblings)	1.8	2.0	3.4	-1.9	0.8
Chronic bronchitis/emphysema (mother)	1.8	2.1	4.2	-2.1	-0.2
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	4.3	-0.3	2.1
Smoking status: Current	1.8	2.9	3.0	1.7	-1.6
Ulcerative Colitis (UC)	1.7	3.2	6.3	-2.5	0.1
Smoking status: Previous	1.7	2.5	4.5	-0.7	-2.1
Eye problems/disorders: Glaucoma	1.7	2.0	2.0	1.4	-1.4
Medication: Atorvastatin	1.7	2.2	4.2	-0.3	-2.1
Bipolar Disorder (2011)	1.6	1.6	3.0	0.4	-1.7
Waist Hip Ratio (WHR)	1.6	7.4	10.2	-3.2	2.1
Neuroticism	1.6	4.0	8.0	0.1	-2.8
Medication: Atenolol	1.6	2.0	2.1	-1.4	-1.4
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.9	1.9	-1.4	-1.3
Lung cancer (father)	1.6	1.8	2.6	-1.1	-1.6
High blood pressure (siblings)	1.6	2.3	4.6	-0.2	-2.1
Current tobacco smoking	1.5	2.5	2.7	1.6	-1.5
Medication: Lansoprazole	1.5	1.7	3.3	-1.8	-0.3
Medication: Ventolin 100micrograms inhaler	1.5	1.9	2.6	-1.6	-1.0
Frequency of depressed mood in last 2 weeks	1.4	1.9	3.2	-0.8	-1.8
Loud music exposure frequency	1.4	1.5	2.1	-1.4	-1.0
Handedness (chirality/laterality): Left-handed	1.4	1.6	3.3	-0.0	-1.8
Mood swings	1.4	2.5	4.1	0.9	-2.0
Number of self-reported non-cancer illnesses	1.4	2.4	3.2	-1.8	-1.3
Miserableness	1.4	2.5	4.0	1.0	-2.0
Hearing aid user	1.4	1.6	3.1	0.1	-1.8
Alzheimer’s Disease (including proxy)	1.3	1.8	2.2	-1.5	-1.2
Mean Putamen Volume	1.3	1.5	3.0	1.7	0.2
Hand grip strength (left)	1.3	3.4	4.7	1.5	-2.2
Medication: Co-codamol	1.3	1.5	1.6	1.3	-1.2
High blood pressure (mother)	1.3	1.9	2.2	1.3	-1.5
Pain all over the body in last month	1.3	1.4	2.1	-1.5	-0.8
Prospective memory result	1.3	1.6	3.2	-0.1	-1.8
Had major operations	1.3	1.5	1.8	-1.3	1.1
Family relationship satisfaction	1.3	1.6	2.7	-1.6	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	2.2	1.5	-1.0
Pain type(s) experienced in last month: Hip pain	1.3	1.7	3.1	-1.8	0.5
Father’s age at death	1.2	1.6	3.0	0.4	-1.7
Diastolic blood pressure, automated reading	1.2	3.8	4.0	1.9	-2.0
Cholesterol lowering medication	1.2	1.8	3.4	-0.3	-1.9
Ovarian Cancer	1.1	1.4	1.9	-1.4	1.0
Neuroticism (2016)	1.1	1.6	2.0	1.4	-1.1
Blood Red Count	1.1	10.6	19.0	-4.4	-1.5
Overall health rating	1.1	2.3	3.7	-1.9	-0.9
Friendships satisfaction	1.1	1.4	1.6	-1.3	-1.1
Worry (Nagel 2018)	1.0	2.1	2.7	-1.2	-1.6
Lupus	1.0	1.6	1.8	-1.2	1.3
Relative age voice broke	1.0	1.5	2.8	-0.6	1.7
High blood pressure	1.0	2.8	4.4	-1.1	-2.1
Falls in the last year	1.0	1.3	2.4	-1.5	-0.5
Number of live births	1.0	1.4	2.3	1.5	-0.7
Illnesses of mother	1.0	1.3	2.2	-1.5	0.6
Age at last live birth	1.0	1.5	2.4	1.5	-0.7
Mother’s age at death	1.0	1.2	2.4	1.6	0.1
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	1.4	1.1	-1.2
Neuroticism (Nagel 2018)	0.9	2.1	4.1	-0.2	-2.0
Serious illness, injury or assault to yourself	0.9	1.1	1.8	-0.6	-1.3
Number of incorrect matches in round	0.9	1.5	2.9	1.7	-0.2
Forced vital capacity (FVC)	0.9	3.4	6.6	-2.6	0.6
Age at first live birth	0.9	1.6	2.8	1.7	-0.5
Emphysema/chronic bronchitis	0.9	1.0	1.2	-1.1	0.9
Chest pain or discomfort	0.9	1.4	2.2	-1.5	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	1.6	0.8	1.3
Hypertension (Self-reported)	0.9	2.5	2.9	-1.5	-1.7
Eye problems/disorders: Cataract	0.9	1.0	1.9	0.3	-1.4
Medication for cholesterol	0.9	1.3	1.6	1.3	1.0
Leg fat percentage (left)	0.9	3.1	3.2	1.7	-1.8
Average weekly beer plus cider intake	0.9	1.3	1.4	-1.1	-1.2
Vascular/heart problems diagnosed by doctor	0.9	2.5	3.3	1.3	1.8
Depressed Affect (Nagel 2018)	0.8	1.6	3.0	0.5	-1.7
Lung FVC	0.8	4.1	8.2	-2.9	0.1
Average weekly spirits intake	0.8	1.0	1.6	1.3	-0.7
Pack years adult smoking proportion	0.8	1.3	1.6	1.0	1.3
Had other major operations	0.8	1.0	2.0	-1.4	-0.2
Neuroticism score	0.8	1.7	3.3	-0.3	-1.8
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	2.0	0.2	-1.4
Glaucoma (self-reported)	0.8	1.0	1.7	1.3	-0.5
Forced vital capacity (FVC), Best measure	0.8	2.9	4.9	-2.2	1.0
Leg fat percentage (right)	0.8	2.8	2.9	1.6	-1.7
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	0.9	-1.0	-0.9
Medication for pain relief, constipation, heartburn	0.8	1.3	2.4	0.5	1.5
Illnesses of siblings: Diabetes	0.8	1.0	1.9	0.0	-1.4
Loneliness, isolation	0.8	1.2	1.8	-1.3	-0.7
Schizophrenia vs Biploar Disorder	0.7	0.9	1.5	-0.6	-1.2
Irritable Bowel Disease (IBD)	0.7	1.6	3.2	-1.8	0.1
Reaction Time	0.7	1.3	2.2	-1.5	-0.7
Hearing difficulty/problems: Yes	0.7	1.1	1.4	-0.8	-1.2
Hand grip strength (right)	0.7	1.9	2.7	1.6	-1.1
Body mass index (BMI)	0.7	3.0	4.0	2.0	-1.4
Mouth/teeth dental problems	0.7	1.0	1.5	1.2	0.7
Hip circumference	0.7	2.9	3.6	1.9	-1.5
Mouth/teeth dental problems: Dentures	0.7	1.2	1.9	-1.4	-0.7
Pulse wave reflection index	0.7	0.9	1.8	-0.2	1.3
Medication: Paracetamol	0.7	1.1	1.5	1.2	-0.9
Mean time to correctly identify matches	0.7	1.4	1.9	-1.4	-1.0
Leg pain on walking	0.7	0.8	1.5	-1.2	0.5
Guilty feelings	0.7	1.1	2.0	0.4	-1.4
Wears glasses or contact lenses	0.7	0.8	1.5	0.3	-1.2
Medication: Blood pressure	0.7	1.3	2.0	-0.8	-1.4
Age started oral contraceptive pill	0.7	0.9	1.1	-0.8	1.1
Bipolar Disorder (2018)	0.6	1.0	1.8	-1.4	-0.4
Blood Eosinophil Count	0.6	4.4	6.5	-1.5	-2.5
Respiratory disease	0.6	1.3	2.7	-1.6	-0.0
Type 2 Diabetes (T2D) (2018)	0.6	1.2	1.4	-1.0	1.2
Diabetes (mother)	0.6	0.8	1.6	-0.1	1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.6	0.2	-1.3
Multivitamins +/- minerals	0.6	0.8	1.6	0.3	-1.2
Hair/balding pattern: Pattern 2	0.6	0.8	1.3	0.5	-1.2
Hayfever/allergic rhinitis (self-reported)	0.6	0.7	1.0	1.0	0.7
Impedance of arm (right)	0.6	2.6	3.5	-1.4	1.9
Length of working week for main job	0.6	0.6	1.3	-0.0	-1.1
Gout (self-reported)	0.6	0.8	1.6	-0.1	-1.2
Medication: Amlodipine	0.6	0.8	1.3	-0.6	-1.1
Medication: Ibuprofen	0.6	0.7	1.3	0.3	-1.1
Medication: Seretide 50 evohaler	0.6	0.7	1.4	-0.3	1.2
Leg fat mass (right)	0.6	2.3	2.5	1.4	-1.6
Knee pain experienced in last month	0.6	0.9	1.7	1.3	-0.2
Average weekly red wine intake	0.6	0.9	1.8	0.3	-1.3
Commuting to job workplace: Walk	0.6	0.7	1.3	-0.3	1.1
High cholesterol (Self-reported)	0.6	1.0	1.9	0.3	-1.4
Medication: Paracetamol	0.6	0.9	1.0	1.0	-0.9
Fractured/broken bones in last 5 years	0.6	0.7	1.4	-0.1	-1.2
Myopia	0.6	0.8	1.5	0.5	-1.2
Pack years of smoking	0.6	0.9	1.1	0.9	1.1
Leg fat mass (left)	0.6	2.1	2.3	1.4	-1.5
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.3	-1.5	0.2
LDL Cholesterol	0.5	0.8	0.9	0.8	1.0
Medication for hormone replacement therapy	0.5	0.5	1.0	-1.0	-0.1
Stomach or abdominal pain in last month	0.5	0.6	1.3	-1.1	0.1
Supplements: Glucosamine	0.5	0.6	1.0	1.0	0.4
Trunk fat mass	0.5	2.3	3.3	1.1	-1.8
Exposure to tobacco smoke at home	0.5	0.6	0.9	-0.5	-1.0
Hair/balding pattern: Pattern 4	0.5	1.2	1.6	-0.9	-1.3
Ever highly irritable/argumentative for 2 days	0.5	0.6	0.8	-0.9	0.6
Blood clot in the leg (DVT)	0.5	0.7	0.7	0.8	-0.8
Body fat percentage	0.5	2.1	2.7	1.3	-1.6
Arm fat-free mass (right)	0.5	2.5	3.2	1.8	-1.3
Number of full brothers	0.5	0.7	1.0	-1.0	0.6
Qualifications: College or University degree	0.5	1.5	2.7	-1.6	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.0	1.0	0.4
Whole body fat mass	0.5	2.1	2.7	1.2	-1.6
Pulse rate, automated reading	0.5	1.8	2.2	-1.5	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.3	1.1	-0.0
Diabetes diagnosed by doctor	0.5	0.7	0.8	-0.8	0.9
Average weekly champagne plus white wine intake	0.5	0.7	1.3	1.1	0.4
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.1	-1.0	-0.1
Supplements: Calcium	0.5	0.5	0.8	-0.5	-0.9
Heart disease (siblings)	0.5	0.7	1.2	0.3	1.1
Body Mass Index (BMI) (2010)	0.4	0.6	1.2	1.1	0.1
Chronotype (morning person)	0.4	0.9	1.6	-0.5	-1.3
Sensitivity / hurt feelings	0.4	0.6	1.1	-0.4	-1.1
Ever had hysterectomy (womb removed)	0.4	0.4	0.7	-0.4	-0.8
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.7	-0.3	-0.8
Medication: Metformin	0.4	0.6	0.9	-0.6	-0.9
Trunk fat percentage	0.4	1.8	2.6	1.0	-1.6
Maternal smoking around birth	0.4	0.6	1.2	-1.1	0.2
Fed-up feelings	0.4	0.7	1.3	0.2	-1.2
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.8	-0.1	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.3	0.2	-1.1
Weight	0.4	2.1	2.3	1.4	-1.5
Arm fat percentage (right)	0.4	1.4	2.3	1.5	-0.7
Happiness	0.4	0.5	1.0	-0.2	-1.0
Impedance of arm (left)	0.4	2.0	2.2	-1.5	1.3
Breastfed as a baby	0.4	0.4	0.7	-0.8	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.0	-1.0	0.4
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.4	1.2	0.2
Shortness of breath walking on level ground	0.4	0.5	0.7	0.4	-0.9
Medication: Omeprazole	0.4	0.5	0.8	-0.9	-0.4
Arm predicted mass (right)	0.4	1.8	2.1	1.2	-1.4
Comparative height size at age 10	0.4	2.1	3.8	0.7	-1.9
Commuting to job workplace: Car/motor vehicle	0.4	0.4	0.8	-0.9	-0.3
Arm fat percentage (left)	0.4	1.8	2.4	1.5	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	0.8	-0.9	-0.6
Breast cancer (self-reported)	0.4	0.5	0.9	-0.4	-1.0
Osteoarthritis (self-reported)	0.4	0.5	1.0	0.1	-1.0
Medication: Gliclazide	0.4	0.5	1.0	0.1	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	0.9	-0.9	1.0
Arm fat mass (left)	0.4	1.7	2.2	1.5	-1.1
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.5	0.7	0.7
Medication: Bendroflumethiazide	0.4	0.6	0.9	-0.5	-0.9
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.8	0.9	0.3
Pain experienced in last month	0.4	0.7	1.4	0.0	1.2
Impedance of whole body	0.4	1.8	2.2	-1.5	1.2
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.6	-1.3	0.4
Crohns Disease (2012)	0.3	0.4	0.6	0.8	0.5
Fasting Glucose	0.3	0.4	0.5	0.5	0.7
BMI	0.3	1.6	1.7	1.3	-1.2
Cardiovascular Disease	0.3	1.0	2.1	-1.4	-0.0
Relative age of first facial hair	0.3	0.5	0.7	0.6	0.8
Impedance of leg (right)	0.3	1.4	2.0	-1.4	0.9
Leg fat-free mass (left)	0.3	1.7	2.2	1.5	-1.1
Age when periods started (menarche)	0.3	0.8	1.4	-0.5	1.2
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.5	-0.3	-0.7
Qualifications: CSEs or equivalent	0.3	0.5	0.8	-0.4	0.9
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.6	-0.1	0.8
Leg predicted mass (left)	0.3	1.8	2.2	1.5	-1.2
Diabetes (self-reported)	0.3	0.5	0.6	-0.7	0.8
Medication: Simvastatin	0.3	0.4	0.7	-0.9	-0.4
Illnesses of siblings	0.3	0.4	0.6	0.8	0.4
Noisy workplace	0.3	0.3	0.5	0.4	0.7
Medication: Cholesterol lowering	0.3	0.5	0.6	-0.8	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.3	-1.2	0.7
Arm fat mass (right)	0.3	1.4	1.9	1.4	-1.0
Exposure to tobacco smoke outside home	0.3	0.4	0.7	-0.2	-0.8
Medication: Blood pressure	0.3	0.6	0.8	-0.9	-0.7
Supplements: Vitamin C	0.3	0.4	0.6	0.8	0.4
Whole body fat-free mass	0.3	2.0	2.1	1.5	-1.4
Leg fat-free mass (right)	0.3	1.7	2.1	1.5	-1.2
Whole body water mass	0.3	1.8	2.1	1.4	-1.2
Leg predicted mass (right)	0.3	1.7	1.9	1.4	-1.2
Commuting to job workplace: Public transport	0.3	0.3	0.7	-0.0	-0.8
Basal metabolic rate	0.3	1.8	2.0	1.4	-1.3
Irritability	0.3	0.4	0.7	-0.9	0.4
Commuting to job workplace: Cycle	0.3	0.3	0.4	-0.4	0.7
Arm predicted mass (left)	0.3	1.4	1.6	1.3	-1.1
Alzheimer’s Disease (in mother)	0.2	0.3	0.4	0.6	-0.4
Major Depression (MDD)	0.2	0.2	0.2	-0.4	0.5
Age at First Birth	0.2	0.2	0.4	0.2	0.6
Heel T-Score	0.2	1.6	1.7	1.2	1.3
Vitamin and mineral supplements	0.2	0.2	0.4	-0.2	0.7
Impedance of leg (left)	0.2	1.2	1.9	-1.4	0.7
Alcohol usually taken with meals	0.2	0.4	0.5	-0.7	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.6	-0.4	0.8
Allergy	0.2	0.4	0.5	0.4	0.7
Trunk fat-free mass	0.2	1.4	1.6	1.3	-1.1
Worrier / anxious feelings	0.2	0.4	0.7	-0.1	-0.8
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.6	-0.8	0.5
Asthma	0.2	0.4	0.5	-0.7	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.3	0.3	-0.6
Pulse wave Arterial Stiffness index	0.2	0.3	0.5	-0.7	0.2
Trunk predicted mass	0.2	1.2	1.3	1.1	-1.0
Birth weight of first child	0.2	0.4	0.8	0.2	0.9
Headache pain in last month	0.2	0.3	0.6	0.8	-0.0
Pulse wave peak to peak time	0.2	0.2	0.4	0.7	-0.2
Number of full sisters	0.2	0.2	0.4	-0.6	0.3
Medication: Aspirin	0.2	0.3	0.4	-0.4	-0.7
Mineral and other dietary supplements	0.2	0.3	0.6	0.1	-0.8
Asthma (self-reported)	0.2	0.4	0.5	-0.4	0.7
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.5	-0.7	0.1
Arm fat-free mass (left)	0.2	1.2	1.8	1.3	-0.8
Ever depressed for a whole week	0.2	0.2	0.5	0.1	-0.7
Breast Cancer	0.1	0.1	0.2	0.2	-0.5
HDL Cholesterol	0.1	0.2	0.3	0.5	-0.5
Height	0.1	2.1	4.1	-2.0	-0.4
Allergy or Eczema	0.1	0.3	0.5	-0.0	-0.7
Hair Pigment	0.1	3.0	5.4	-0.8	2.3
Tanning	0.1	0.8	1.1	1.1	-0.7
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.0	-0.5
Supplements: Zinc	0.1	0.1	0.2	0.2	-0.4
Townsend deprivation index at recruitment	0.1	0.2	0.3	-0.5	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.4	-0.3	0.6
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.6	-0.0	-0.8
Nervous feelings	0.1	0.3	0.5	-0.3	-0.7
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.2	-0.3	0.5
Qualifications: None of the above	0.1	0.2	0.2	0.5	-0.3
Medication: Ramipril	0.1	0.2	0.3	-0.2	0.5
Fluid intelligence score	0.1	0.2	0.3	-0.5	0.5
Time employed in main current job	0.1	0.1	0.1	-0.4	0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	1.0	-1.0	0.1
Pulse rate	0.1	0.1	0.2	0.4	-0.3
Standing height	0.1	0.7	1.2	-1.1	-0.5
Peak expiratory flow (PEF)	0.1	0.2	0.3	-0.2	-0.5
Wheeze or whistling in the chest in last year	0.1	0.2	0.2	-0.4	0.5
Health satisfaction	0.1	0.2	0.3	0.2	-0.5
Angina (self-reported)	0.1	0.1	0.1	-0.3	0.3
Medication: Allopurinol	0.1	0.1	0.3	0.5	-0.1
Heart disease (mother)	0.1	0.2	0.2	0.4	0.5
Suffer from ‘nerves’	0.1	0.1	0.2	-0.2	-0.5
Illnesses of father: Heart disease	0.1	0.1	0.2	-0.4	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.3	0.6	-0.1
Qualifications: nursing, teaching	0.1	0.1	0.2	0.2	-0.4
Medication: Aspirin	0.1	0.1	0.2	-0.4	-0.2
Illnesses of father: High blood pressure	0.1	0.2	0.3	0.3	0.5
Crohns Disease (2017)	0.0	0.0	0.0	0.2	0.1
Primary Biliary Cirrhosis	0.0	0.1	0.1	-0.3	-0.2
Triglycerides	0.0	0.0	0.0	0.0	-0.2
Systolic Blood Pressure	0.0	0.1	0.2	-0.1	-0.5
Angina	0.0	0.1	0.1	-0.3	0.2
Average weekly fortified wine intake	0.0	0.0	0.0	0.0	0.2
Sitting height	0.0	0.2	0.2	-0.3	0.5
Waist circumference	0.0	0.2	0.3	-0.1	-0.5
Financial difficulties in last 2 years	0.0	0.0	0.0	0.1	0.1
Back pain experienced in last month	0.0	0.0	0.0	0.1	0.0
Illnesses of father: None of the above (group 1)	0.0	0.1	0.1	0.3	0.1
Number of operations (self-reported)	0.0	0.0	0.0	0.1	-0.0
Basal cell carcinoma (self-reported)	0.0	0.0	0.0	0.0	-0.1

Hub : Genes

MARCH7

Models

Trait associations