Hub : Genes

MARCH7

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Thyroid 0.061 0.027 2.2e-03 0.012 NA 0.003 NA 0.008 0.039 NA 1.8e-01 NA 0.07800
2 YFS Blood 0.110 0.029 3.1e-08 0.000 0.033 0.032 0.042 0.011 0.420 4e-11 1.2e-10 1.5e-13 0.00013

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.6 1.0 1.8 -1.4 -0.4
Bipolar Disorder or Schizophrenia 3.0 7.3 7.8 -2.6 -2.8
Depressed Affect (Nagel 2018) 0.8 1.6 3.0 0.5 -1.7
Depression (Nagel 2018) 1.9 2.8 5.1 -0.7 -2.3
Intelligence (Savage-Jansen 2018) 0.3 0.9 1.6 -1.3 0.4
Neuroticism (Nagel 2018) 0.9 2.1 4.1 -0.2 -2.0
Schizophrenia (2018) 3.7 7.8 10.9 -2.1 -3.3
Schizophrenia vs Biploar Disorder 0.7 0.9 1.5 -0.6 -1.2
Worry (Nagel 2018) 1.0 2.1 2.7 -1.2 -1.6
Alzheimer’s Disease (in mother) 0.2 0.3 0.4 0.6 -0.4
Alzheimer’s Disease (in father) 2.1 2.3 3.6 -1.0 -1.9
Alzheimer’s Disease (including proxy) 1.3 1.8 2.2 -1.5 -1.2
Crohns Disease (2017) 0.0 0.0 0.0 0.2 0.1
Irritable Bowel Disease (IBD) 0.7 1.6 3.2 -1.8 0.1
Ulcerative Colitis (UC) 1.7 3.2 6.3 -2.5 0.1
Major Depression (MDD) 0.2 0.2 0.2 -0.4 0.5
Reaction Time 0.7 1.3 2.2 -1.5 -0.7
Verbal and Numeric Reasoning (VNR) 0.5 1.2 2.3 -1.5 0.2
Breast Cancer 0.1 0.1 0.2 0.2 -0.5
Ovarian Cancer 1.1 1.4 1.9 -1.4 1.0
Prostate Cancer 2.3 3.3 5.3 1.1 2.3
Age at First Birth 0.2 0.2 0.4 0.2 0.6
Bipolar Disorder (2011) 1.6 1.6 3.0 0.4 -1.7
Body Mass Index (BMI) (2010) 0.4 0.6 1.2 1.1 0.1
Coronary Artery Disease (CAD) 2.0 2.4 3.6 -1.9 1.0
Crohns Disease (2012) 0.3 0.4 0.6 0.8 0.5
Mean Putamen Volume 1.3 1.5 3.0 1.7 0.2
Fasting Glucose 0.3 0.4 0.5 0.5 0.7
HbA1C 2.1 2.3 4.4 -0.5 2.1
HDL Cholesterol 0.1 0.2 0.3 0.5 -0.5
LDL Cholesterol 0.5 0.8 0.9 0.8 1.0
Lupus 1.0 1.6 1.8 -1.2 1.3
Neuroticism (2016) 1.1 1.6 2.0 1.4 -1.1
Primary Biliary Cirrhosis 0.0 0.1 0.1 -0.3 -0.2
Rheumatoid Arthritis 2.6 3.6 6.9 0.5 -2.6
Schizophrenia (2014) 3.6 8.0 9.4 -3.1 -2.5
Triglycerides 0.0 0.0 0.0 0.0 -0.2
Type 2 Diabetes (T2D) (2012) 2.4 2.7 3.2 -1.5 1.8
Ulcerative Colitis 3.6 5.2 6.7 -2.6 1.9
Blood Eosinophil Count 0.6 4.4 6.5 -1.5 -2.5
Blood Platelet Count 2.8 32.4 63.5 -8.0 -1.2
Blood Red Count 1.1 10.6 19.0 -4.4 -1.5
Blood White Count 4.0 29.5 59.0 -7.7 0.2
Heel T-Score 0.2 1.6 1.7 1.2 1.3
BMI 0.3 1.6 1.7 1.3 -1.2
Height 0.1 2.1 4.1 -2.0 -0.4
Waist Hip Ratio (WHR) 1.6 7.4 10.2 -3.2 2.1
Systolic Blood Pressure 0.0 0.1 0.2 -0.1 -0.5
Smoking Status 3.1 7.3 9.6 2.2 -3.1
Allergy or Eczema 0.1 0.3 0.5 -0.0 -0.7
Cardiovascular Disease 0.3 1.0 2.1 -1.4 -0.0
Hypothyroidism (self reported) 1.9 4.3 8.4 -2.9 -0.4
Respiratory disease 0.6 1.3 2.7 -1.6 -0.0
Type 2 Diabetes (T2D) (2018) 0.6 1.2 1.4 -1.0 1.2
Lung FEV1/FVC ratio 3.8 19.3 37.3 6.1 -1.1
Lung FVC 0.8 4.1 8.2 -2.9 0.1
Neuroticism 1.6 4.0 8.0 0.1 -2.8
Chronotype (morning person) 0.4 0.9 1.6 -0.5 -1.3
Hair Pigment 0.1 3.0 5.4 -0.8 2.3
Tanning 0.1 0.8 1.1 1.1 -0.7
Hand grip strength (left) 1.3 3.4 4.7 1.5 -2.2
Number of treatments/medications taken 2.0 3.5 6.2 -2.5 -0.9
Average weekly spirits intake 0.8 1.0 1.6 1.3 -0.7
Sensitivity / hurt feelings 0.4 0.6 1.1 -0.4 -1.1
Frequency of depressed mood in last 2 weeks 1.4 1.9 3.2 -0.8 -1.8
Hearing difficulty/problems: Yes 0.7 1.1 1.4 -0.8 -1.2
Relative age of first facial hair 0.3 0.5 0.7 0.6 0.8
Other serious medical condition/disability diagnosed by doctor 3.0 3.9 7.3 -2.7 0.7
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.2 -0.0 -0.5
Ever had hysterectomy (womb removed) 0.4 0.4 0.7 -0.4 -0.8
Systolic blood pressure, automated reading 1.8 5.3 8.4 1.5 -2.9
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 0.7 -0.3 -0.8
Angina 0.0 0.1 0.1 -0.3 0.2
Medication for hormone replacement therapy 0.5 0.5 1.0 -1.0 -0.1
Vitamin and mineral supplements 0.2 0.2 0.4 -0.2 0.7
Supplements: Zinc 0.1 0.1 0.2 0.2 -0.4
Medication: Co-codamol 1.3 1.5 1.6 1.3 -1.2
Medication: Metformin 0.4 0.6 0.9 -0.6 -0.9
Diabetes (father) 2.4 2.9 5.1 2.3 -0.9
Diabetes (mother) 0.6 0.8 1.6 -0.1 1.3
Severe depression (siblings) 1.8 2.0 3.4 -1.9 0.8
Pack years adult smoking proportion 0.8 1.3 1.6 1.0 1.3
Impedance of leg (right) 0.3 1.4 2.0 -1.4 0.9
Leg fat-free mass (left) 0.3 1.7 2.2 1.5 -1.1
Trunk fat percentage 0.4 1.8 2.6 1.0 -1.6
Hand grip strength (right) 0.7 1.9 2.7 1.6 -1.1
Townsend deprivation index at recruitment 0.1 0.2 0.3 -0.5 0.3
Current tobacco smoking 1.5 2.5 2.7 1.6 -1.5
Average weekly fortified wine intake 0.0 0.0 0.0 0.0 0.2
Maternal smoking around birth 0.4 0.6 1.2 -1.1 0.2
Fed-up feelings 0.4 0.7 1.3 0.2 -1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 1.6 0.2 -1.3
Relative age voice broke 1.0 1.5 2.8 -0.6 1.7
Taking other prescription medications 2.9 4.5 6.9 -2.6 -1.4
Age when periods started (menarche) 0.3 0.8 1.4 -0.5 1.2
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 0.5 -0.3 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.4 -0.3 0.6
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 0.8 -0.1 -0.9
Qualifications: CSEs or equivalent 0.3 0.5 0.8 -0.4 0.9
Serious illness, injury or assault to yourself 0.9 1.1 1.8 -0.6 -1.3
High blood pressure 1.0 2.8 4.4 -1.1 -2.1
Hayfever, allergic rhinitis or eczema 0.1 0.3 0.6 -0.0 -0.8
Multivitamins +/- minerals 0.6 0.8 1.6 0.3 -1.2
Stomach or abdominal pain in last month 0.5 0.6 1.3 -1.1 0.1
Supplements: Glucosamine 0.5 0.6 1.0 1.0 0.4
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 0.6 -0.1 0.8
Medication: Atenolol 1.6 2.0 2.1 -1.4 -1.4
Medication: Levothyroxine sodium 3.6 6.1 12.2 -3.5 0.1
Sitting height 0.0 0.2 0.2 -0.3 0.5
Chronic bronchitis/emphysema (father) 2.5 2.9 5.6 -2.4 -0.4
High blood pressure (mother) 1.3 1.9 2.2 1.3 -1.5
Body mass index (BMI) 0.7 3.0 4.0 2.0 -1.4
Impedance of leg (left) 0.2 1.2 1.9 -1.4 0.7
Leg predicted mass (left) 0.3 1.8 2.2 1.5 -1.2
Trunk fat mass 0.5 2.3 3.3 1.1 -1.8
Waist circumference 0.0 0.2 0.3 -0.1 -0.5
Number of incorrect matches in round 0.9 1.5 2.9 1.7 -0.2
Past tobacco smoking 2.6 4.8 9.5 0.3 3.1
Alcohol usually taken with meals 0.2 0.4 0.5 -0.7 -0.6
Nervous feelings 0.1 0.3 0.5 -0.3 -0.7
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.3 0.2 -1.1
Hearing difficulty/problems with background noise 2.8 4.5 9.0 -3.0 -0.0
Hair/balding pattern: Pattern 2 0.6 0.8 1.3 0.5 -1.2
Had menopause 3.2 4.0 7.5 2.7 -0.8
Had other major operations 0.8 1.0 2.0 -1.4 -0.2
Forced vital capacity (FVC) 0.9 3.4 6.6 -2.6 0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 0.6 -0.4 0.8
Ever unenthusiastic/disinterested for a whole week 0.1 0.2 0.2 -0.3 0.5
Qualifications: None of the above 0.1 0.2 0.2 0.5 -0.3
Financial difficulties in last 2 years 0.0 0.0 0.0 0.1 0.1
Mouth/teeth dental problems 0.7 1.0 1.5 1.2 0.7
Heart attack 2.1 2.7 4.7 -0.9 -2.2
Allergy 0.2 0.4 0.5 0.4 0.7
Pain all over the body in last month 1.3 1.4 2.1 -1.5 -0.8
Diabetes (self-reported) 0.3 0.5 0.6 -0.7 0.8
Hayfever/allergic rhinitis (self-reported) 0.6 0.7 1.0 1.0 0.7
Medication: Ramipril 0.1 0.2 0.3 -0.2 0.5
Medication: Simvastatin 0.3 0.4 0.7 -0.9 -0.4
Fluid intelligence score 0.1 0.2 0.3 -0.5 0.5
Illnesses of siblings 0.3 0.4 0.6 0.8 0.4
Neuroticism score 0.8 1.7 3.3 -0.3 -1.8
Weight 0.4 2.1 2.3 1.4 -1.5
Impedance of arm (right) 0.6 2.6 3.5 -1.4 1.9
Arm fat percentage (right) 0.4 1.4 2.3 1.5 -0.7
Trunk fat-free mass 0.2 1.4 1.6 1.3 -1.1
Hip circumference 0.7 2.9 3.6 1.9 -1.5
Time employed in main current job 0.1 0.1 0.1 -0.4 0.3
Alcohol intake versus 10 years previously 3.1 4.6 8.8 -3.0 0.7
Father’s age at death 1.2 1.6 3.0 0.4 -1.7
Worrier / anxious feelings 0.2 0.4 0.7 -0.1 -0.8
Frequency of tiredness / lethargy in last 2 weeks 3.5 5.8 9.3 -1.5 -3.0
Falls in the last year 1.0 1.3 2.4 -1.5 -0.5
Hair/balding pattern: Pattern 3 2.6 3.8 3.8 2.0 1.9
Number of live births 1.0 1.4 2.3 1.5 -0.7
Forced expiratory volume in 1-second (FEV1) 0.1 0.5 1.0 -1.0 0.1
Pulse rate 0.1 0.1 0.2 0.4 -0.3
Happiness 0.4 0.5 1.0 -0.2 -1.0
Noisy workplace 0.3 0.3 0.5 0.4 0.7
Qualifications: A levels/AS levels or equivalent 0.2 0.4 0.6 -0.8 0.5
Serious illness, injury or assault of a close relative in last 2 years 1.6 1.9 1.9 -1.4 -1.3
Mouth/teeth dental problems: Dentures 0.7 1.2 1.9 -1.4 -0.7
Asthma 0.2 0.4 0.5 -0.7 0.5
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.2 0.3 0.3 -0.6
Medication: Cholesterol lowering 0.3 0.5 0.6 -0.8 0.6
Depression (self-reported) 2.3 2.8 4.5 -1.0 -2.1
Medication: Lansoprazole 1.5 1.7 3.3 -1.8 -0.3
Prospective memory result 1.3 1.6 3.2 -0.1 -1.8
Lung cancer (father) 1.6 1.8 2.6 -1.1 -1.6
Illnesses of mother 1.0 1.3 2.2 -1.5 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 1.3 -1.2 0.7
Pulse wave Arterial Stiffness index 0.2 0.3 0.5 -0.7 0.2
Impedance of arm (left) 0.4 2.0 2.2 -1.5 1.3
Arm fat mass (right) 0.3 1.4 1.9 1.4 -1.0
Trunk predicted mass 0.2 1.2 1.3 1.1 -1.0
Standing height 0.1 0.7 1.2 -1.1 -0.5
Length of working week for main job 0.6 0.6 1.3 -0.0 -1.1
Exposure to tobacco smoke at home 0.5 0.6 0.9 -0.5 -1.0
Breastfed as a baby 0.4 0.4 0.7 -0.8 0.4
Tense / ‘highly strung’ 2.9 4.8 5.2 -2.1 -2.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 1.0 -1.0 0.4
Hair/balding pattern: Pattern 4 0.5 1.2 1.6 -0.9 -1.3
Birth weight of first child 0.2 0.4 0.8 0.2 0.9
Peak expiratory flow (PEF) 0.1 0.2 0.3 -0.2 -0.5
Pulse wave reflection index 0.7 0.9 1.8 -0.2 1.3
Ever highly irritable/argumentative for 2 days 0.5 0.6 0.8 -0.9 0.6
Loud music exposure frequency 1.4 1.5 2.1 -1.4 -1.0
Qualifications: O levels/GCSEs or equivalent 3.0 4.7 9.1 0.6 3.0
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 2.0 0.2 -1.4
Blood clot in the leg (DVT) 0.5 0.7 0.7 0.8 -0.8
Medication: Paracetamol 0.7 1.1 1.5 1.2 -0.9
Headache pain in last month 0.2 0.3 0.6 0.8 -0.0
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 1.4 1.2 0.2
Glaucoma (self-reported) 0.8 1.0 1.7 1.3 -0.5
Gout (self-reported) 0.6 0.8 1.6 -0.1 -1.2
Hypothyroidism/myxoedema (self-reported) 2.7 5.3 10.6 -3.2 -0.3
Medication: Amlodipine 0.6 0.8 1.3 -0.6 -1.1
Medication: Ventolin 100micrograms inhaler 1.5 1.9 2.6 -1.6 -1.0
Birth weight 2.0 4.4 7.8 2.8 1.0
Chronic bronchitis/emphysema (mother) 1.8 2.1 4.2 -2.1 -0.2
High blood pressure (siblings) 1.6 2.3 4.6 -0.2 -2.1
Forced vital capacity (FVC), Best measure 0.8 2.9 4.9 -2.2 1.0
Body fat percentage 0.5 2.1 2.7 1.3 -1.6
Leg fat percentage (right) 0.8 2.8 2.9 1.6 -1.7
Arm fat-free mass (right) 0.5 2.5 3.2 1.8 -1.3
Exposure to tobacco smoke outside home 0.3 0.4 0.7 -0.2 -0.8
Comparative body size at age 10 3.1 8.4 13.8 3.7 -1.8
Number of full brothers 0.5 0.7 1.0 -1.0 0.6
Worry too long after embarrassment 2.3 3.9 7.8 -0.0 -2.8
Seen a psychiatrist for nerves, anxiety, tension or depression 2.4 3.1 5.7 -2.4 0.7
Wheeze or whistling in the chest in last year 0.1 0.2 0.2 -0.4 0.5
Number of children fathered 2.0 2.3 3.3 -1.1 -1.8
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 0.9 -1.0 -0.9
Age at first live birth 0.9 1.6 2.8 1.7 -0.5
Pulse wave peak to peak time 0.2 0.2 0.4 0.7 -0.2
Health satisfaction 0.1 0.2 0.3 0.2 -0.5
Shortness of breath walking on level ground 0.4 0.5 0.7 0.4 -0.9
Qualifications: College or University degree 0.5 1.5 2.7 -1.6 0.5
Eye problems/disorders: None of the above 2.5 2.9 5.6 0.4 2.4
Mouth/teeth dental problems: Loose teeth 2.5 2.9 3.2 1.8 1.6
Emphysema/chronic bronchitis 0.9 1.0 1.2 -1.1 0.9
Medication for pain relief, constipation, heartburn 0.8 1.3 2.4 0.5 1.5
Neck or shoulder pain in last month 1.9 2.7 4.5 -1.0 -2.1
Medication: Blood pressure 0.3 0.6 0.8 -0.9 -0.7
Angina (self-reported) 0.1 0.1 0.1 -0.3 0.3
Migraine (self-reported) 4.1 5.1 10.2 0.2 -3.2
Medication: Ibuprofen 0.6 0.7 1.3 0.3 -1.1
Medication: Allopurinol 0.1 0.1 0.3 0.5 -0.1
Medication: Omeprazole 0.4 0.5 0.8 -0.9 -0.4
Medication: Seretide 50 evohaler 0.6 0.7 1.4 -0.3 1.2
Mean time to correctly identify matches 0.7 1.4 1.9 -1.4 -1.0
Heart disease (mother) 0.1 0.2 0.2 0.4 0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.0 1.0 0.4
Whole body fat mass 0.5 2.1 2.7 1.2 -1.6
Leg fat mass (right) 0.6 2.3 2.5 1.4 -1.6
Arm predicted mass (right) 0.4 1.8 2.1 1.2 -1.4
Pulse rate, automated reading 0.5 1.8 2.2 -1.5 -1.2
Alcohol intake frequency. 2.0 4.6 8.2 -2.9 1.0
Comparative height size at age 10 0.4 2.1 3.8 0.7 -1.9
Number of full sisters 0.2 0.2 0.4 -0.6 0.3
Suffer from ‘nerves’ 0.1 0.1 0.2 -0.2 -0.5
Overall health rating 1.1 2.3 3.7 -1.9 -0.9
Chest pain or discomfort 0.9 1.4 2.2 -1.5 -0.7
Had major operations 1.3 1.5 1.8 -1.3 1.1
Age at last live birth 1.0 1.5 2.4 1.5 -0.7
Family relationship satisfaction 1.3 1.6 2.7 -1.6 -0.8
Leg pain on walking 0.7 0.8 1.5 -1.2 0.5
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 1.6 0.8 1.3
Commuting to job workplace: Car/motor vehicle 0.4 0.4 0.8 -0.9 -0.3
Illness, injury, bereavement, stress in last 2 years 1.8 2.2 4.3 -0.3 2.1
Medication: Aspirin 0.2 0.3 0.4 -0.4 -0.7
Supplements: Vitamin C 0.3 0.4 0.6 0.8 0.4
Knee pain experienced in last month 0.6 0.9 1.7 1.3 -0.2
Hypertension (Self-reported) 0.9 2.5 2.9 -1.5 -1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.3 1.1 -0.0
Illnesses of father: Heart disease 0.1 0.1 0.2 -0.4 -0.3
Illnesses of siblings: Diabetes 0.8 1.0 1.9 0.0 -1.4
Smoking status: Previous 1.7 2.5 4.5 -0.7 -2.1
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.3 0.6 -0.1
Whole body fat-free mass 0.3 2.0 2.1 1.5 -1.4
Leg fat-free mass (right) 0.3 1.7 2.1 1.5 -1.2
Arm fat percentage (left) 0.4 1.8 2.4 1.5 -1.1
Average weekly red wine intake 0.6 0.9 1.8 0.3 -1.3
Handedness (chirality/laterality): Left-handed 1.4 1.6 3.3 -0.0 -1.8
Mood swings 1.4 2.5 4.1 0.9 -2.0
Loneliness, isolation 0.8 1.2 1.8 -1.3 -0.7
Long-standing illness, disability or infirmity 2.3 3.4 6.7 -2.6 -0.5
Ever had bowel cancer screening 2.4 2.8 3.3 -1.8 -1.5
Diabetes diagnosed by doctor 0.5 0.7 0.8 -0.8 0.9
Ever had stillbirth, spontaneous miscarriage or termination 3.6 3.8 3.9 -1.9 -2.0
Friendships satisfaction 1.1 1.4 1.6 -1.3 -1.1
Qualifications: nursing, teaching 0.1 0.1 0.2 0.2 -0.4
Commuting to job workplace: Walk 0.6 0.7 1.3 -0.3 1.1
Eye problems/disorders: Cataract 0.9 1.0 1.9 0.3 -1.4
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 0.8 -0.9 -0.6
Medication for cholesterol 0.9 1.3 1.6 1.3 1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.3 1.5 2.2 1.5 -1.0
Back pain experienced in last month 0.0 0.0 0.0 0.1 0.0
Mineral and other dietary supplements 0.2 0.3 0.6 0.1 -0.8
Breast cancer (self-reported) 0.4 0.5 0.9 -0.4 -1.0
Asthma (self-reported) 0.2 0.4 0.5 -0.4 0.7
Osteoporosis (self-reported) 2.5 3.0 4.8 -1.1 2.2
Osteoarthritis (self-reported) 0.4 0.5 1.0 0.1 -1.0
Medication: Aspirin 0.1 0.1 0.2 -0.4 -0.2
Medication: Gliclazide 0.4 0.5 1.0 0.1 1.0
Illnesses of father: None of the above (group 1) 0.0 0.1 0.1 0.3 0.1
Smoking status: Current 1.8 2.9 3.0 1.7 -1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 0.9 -0.9 1.0
Whole body water mass 0.3 1.8 2.1 1.4 -1.2
Leg predicted mass (right) 0.3 1.7 1.9 1.4 -1.2
Arm fat mass (left) 0.4 1.7 2.2 1.5 -1.1
Number of self-reported non-cancer illnesses 1.4 2.4 3.2 -1.8 -1.3
Average weekly champagne plus white wine intake 0.5 0.7 1.3 1.1 0.4
Miserableness 1.4 2.5 4.0 1.0 -2.0
Guilty feelings 0.7 1.1 2.0 0.4 -1.4
Wears glasses or contact lenses 0.7 0.8 1.5 0.3 -1.2
Ever taken oral contraceptive pill 2.3 2.6 4.8 -2.2 0.6
Hearing aid user 1.4 1.6 3.1 0.1 -1.8
Mother’s age at death 1.0 1.2 2.4 1.6 0.1
Financial situation satisfaction 2.2 2.7 3.3 -1.5 -1.8
Tinnitus: Yes, now most or all of the time 0.2 0.3 0.5 -0.7 0.1
Commuting to job workplace: Public transport 0.3 0.3 0.7 -0.0 -0.8
Eye problems/disorders: Glaucoma 1.7 2.0 2.0 1.4 -1.4
Medication: Blood pressure 0.7 1.3 2.0 -0.8 -1.4
Pain type(s) experienced in last month: Hip pain 1.3 1.7 3.1 -1.8 0.5
Supplements: Fish oil (including cod liver oil) 0.4 0.5 0.5 0.7 0.7
High cholesterol (Self-reported) 0.6 1.0 1.9 0.3 -1.4
Medication: Bendroflumethiazide 0.4 0.6 0.9 -0.5 -0.9
Medication: Paracetamol 0.6 0.9 1.0 1.0 -0.9
Medication: Lisinopril 2.5 3.2 5.2 -1.1 -2.3
Medication: Atorvastatin 1.7 2.2 4.2 -0.3 -2.1
Illnesses of father: High blood pressure 0.1 0.2 0.3 0.3 0.5
Alcohol drinker status: Never 3.3 3.9 7.7 -2.8 0.3
Ever smoked 2.1 3.6 7.0 0.6 -2.6
Basal metabolic rate 0.3 1.8 2.0 1.4 -1.3
Leg fat percentage (left) 0.9 3.1 3.2 1.7 -1.8
Arm fat-free mass (left) 0.2 1.2 1.8 1.3 -0.8
Number of operations (self-reported) 0.0 0.0 0.0 0.1 -0.0
Average weekly beer plus cider intake 0.9 1.3 1.4 -1.1 -1.2
Irritability 0.3 0.4 0.7 -0.9 0.4
Risk taking 3.0 4.4 8.1 -2.8 -0.8
Ever had prostate specific antigen (PSA) test 0.4 0.4 0.8 0.9 0.3
Fractured/broken bones in last 5 years 0.6 0.7 1.4 -0.1 -1.2
Age started oral contraceptive pill 0.7 0.9 1.1 -0.8 1.1
Diastolic blood pressure, automated reading 1.2 3.8 4.0 1.9 -2.0
Ever depressed for a whole week 0.2 0.2 0.5 0.1 -0.7
Unable to work because of sickness or disability 2.5 3.2 4.3 -2.1 -1.5
Commuting to job workplace: Cycle 0.3 0.3 0.4 -0.4 0.7
Myopia 0.6 0.8 1.5 0.5 -1.2
Vascular/heart problems diagnosed by doctor 0.9 2.5 3.3 1.3 1.8
Cholesterol lowering medication 1.2 1.8 3.4 -0.3 -1.9
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.1 -1.0 -0.1
Pain experienced in last month 0.4 0.7 1.4 0.0 1.2
Supplements: Calcium 0.5 0.5 0.8 -0.5 -0.9
Basal cell carcinoma (self-reported) 0.0 0.0 0.0 0.0 -0.1
Heart attack/myocardial infarction (self-reported) 2.2 2.9 4.8 -1.0 -2.2
Deep venous thrombosis (DVT) (self-reported) 1.0 1.3 1.4 1.1 -1.2
Heart disease (siblings) 0.5 0.7 1.2 0.3 1.1
Alcohol drinker status: Previous 3.9 4.5 8.3 -2.9 0.8
Pack years of smoking 0.6 0.9 1.1 0.9 1.1
Impedance of whole body 0.4 1.8 2.2 -1.5 1.2
Leg fat mass (left) 0.6 2.1 2.3 1.4 -1.5
Arm predicted mass (left) 0.3 1.4 1.6 1.3 -1.1