TWAS hub - PLA2R1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0930	0.0430	2.7e-03	0.030	NA	0.033	NA	0.018	1.6e-03	NA	1.0e-03	NA	1.2e-02
2	GTEx	Artery Tibial	0.1511	0.0648	3.5e-04	0.020	NA	0.013	NA	0.030	9.9e-03	NA	2.9e-02	NA	2.0e-03
3	GTEx	Cells Transformed fibroblasts	0.2560	0.0650	7.8e-12	0.164	NA	0.167	NA	0.166	2.5e-12	NA	1.4e-12	NA	1.8e-12
4	GTEx	Colon Sigmoid	0.1860	0.0840	3.2e-03	0.154	NA	0.079	NA	0.140	4.2e-06	NA	9.6e-04	NA	1.2e-05
5	GTEx	Colon Transverse	0.1200	0.0530	6.0e-03	0.101	NA	0.018	NA	0.071	1.6e-05	NA	4.5e-02	NA	2.9e-04
6	GTEx	Esophagus Mucosa	0.2470	0.0590	1.1e-11	0.183	NA	0.235	NA	0.273	2.6e-12	NA	9.8e-16	NA	2.0e-18
7	GTEx	Esophagus Muscularis	0.0720	0.0340	2.8e-03	0.074	NA	0.067	NA	0.059	3.1e-05	NA	6.8e-05	NA	1.8e-04
8	GTEx	Lung	0.1157	0.0518	2.0e-03	0.014	NA	-0.001	NA	0.004	2.6e-02	NA	3.8e-01	NA	1.6e-01
9	GTEx	Muscle Skeletal	0.0380	0.0192	4.7e-03	0.030	NA	0.028	NA	0.026	5.4e-04	NA	7.8e-04	NA	1.3e-03
10	GTEx	Nerve Tibial	0.1089	0.0520	8.8e-04	0.079	NA	0.041	NA	0.078	3.2e-06	NA	7.1e-04	NA	3.7e-06
11	GTEx	Thyroid	0.1010	0.0340	2.5e-06	0.093	NA	0.100	NA	0.110	1.3e-07	NA	4.4e-08	NA	8.7e-09
12	GTEx	Vagina	0.1970	0.0860	6.4e-03	-0.009	NA	0.027	NA	-0.006	6.0e-01	NA	8.2e-02	NA	4.7e-01
13	ROSMAP	Brain Pre-frontal Cortex	0.0518	0.0234	2.1e-03	0.035	0.028	0.023	0.026	0.025	2.3e-05	1.5e-04	5.0e-04	0.00026	3.2e-04
14	TCGA	Breast Invasive Carcinoma	0.0532	0.0203	7.6e-06	0.029	0.042	0.025	NA	0.028	8.5e-07	5.3e-09	5.3e-06	NA	1.9e-06
15	TCGA	Head and Neck Squamous Cell Carcinoma	0.0600	0.0298	6.9e-04	0.009	0.005	0.002	NA	0.004	2.6e-02	8.4e-02	2.0e-01	NA	1.1e-01
16	TCGA	Kidney Renal Clear Cell Carcinoma	0.0567	0.0314	8.9e-03	0.013	0.012	0.009	NA	0.011	1.2e-02	1.5e-02	2.9e-02	NA	2.0e-02
17	TCGA	Lung Adenocarcinoma	0.0624	0.0343	3.8e-03	0.030	0.016	0.001	NA	0.015	1.7e-04	5.0e-03	2.0e-01	NA	6.4e-03
18	TCGA	Lung Squamous Cell Carcinoma	0.0542	0.0289	1.3e-03	0.044	0.023	0.024	NA	0.033	8.8e-06	1.1e-03	7.5e-04	NA	1.0e-04
19	TCGA	Prostate Adenocarcinoma	0.2416	0.0663	1.2e-08	0.074	0.100	0.131	NA	0.097	3.5e-08	1.5e-10	1.4e-13	NA	2.3e-10
20	TCGA	Thyroid Carcinoma	0.0350	0.0220	8.7e-03	0.009	0.011	-0.002	NA	0.014	4.3e-02	2.6e-02	6.0e-01	NA	1.5e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
Blood White Count	7.8	57.8	141.6	10.0	5.5	9.1	7.1	7.0	8.0	9.1	4.0	8.6	7.0	3.7	11.9	-3.4	6.7	6.6	6.5	7.2	7.6	10.8	5.8
Ever smoked	6.7	11.8	21.8	3.6	3.6	4.1	3.8	4.7	3.5	3.8	1.7	4.0	4.1	2.5	3.0	-1.0	2.1	2.9	3.3	3.9	4.1	3.4	3.3
Birth weight	6.5	14.1	26.8	-5.0	-3.1	-4.8	-3.8	-4.5	-3.5	-4.0	-2.8	-4.2	-3.9	-2.4	-5.2	2.4	-2.2	-3.7	-3.5	-2.8	-4.3	-4.0	-2.8
Comparative body size at age 10	4.7	12.9	31.6	-5.6	-2.7	-4.3	-3.8	-3.9	-3.9	-4.1	-3.1	-4.1	-3.4	-1.3	-5.3	-0.7	-2.8	-2.3	-3.5	-3.8	-3.8	-3.5	-2.1
Wheeze or whistling in the chest in last year	4.5	8.0	27.7	2.7	1.3	3.5	2.4	2.0	2.9	3.4	0.1	3.0	2.3	2.0	3.8	-2.5	2.6	3.0	2.6	2.3	3.1	5.3	2.3
Past tobacco smoking	4.3	7.9	15.5	-2.7	-3.0	-3.5	-2.9	-3.9	-2.6	-3.2	-1.8	-3.1	-3.4	-2.0	-2.3	1.0	-1.8	-2.7	-3.1	-2.8	-3.3	-2.8	-2.6
Knee pain experienced in last month	4.2	6.6	10.8	2.2	3.2	2.8	2.6	2.1	2.5	3.2	0.6	2.6	3.3	2.7	2.4	-1.1	2.5	2.5	2.4	2.9	3.1	1.9	3.0
Hearing difficulty/problems: Yes	4.1	6.3	11.9	2.4	2.7	3.3	2.7	3.2	1.7	2.4	3.4	2.4	3.1	2.1	3.2	-0.8	0.8	1.3	2.2	2.6	3.1	2.2	2.5
Smoking Status	3.9	9.4	17.6	2.9	2.4	3.8	3.6	3.1	4.2	4.0	0.1	3.8	3.1	3.6	2.1	-2.0	2.3	2.9	1.5	2.2	3.6	3.3	3.6
Seen doctor (GP) for nerves, anxiety, tension or depression	3.9	6.0	16.3	2.4	2.6	2.4	1.9	0.9	3.0	3.3	0.7	2.2	2.4	1.4	3.3	-1.8	4.0	3.7	2.0	2.1	2.0	2.1	1.9
Medication: Lisinopril	3.9	5.0	12.8	-1.9	-2.5	-2.4	-3.1	-2.9	-1.9	-1.9	-2.5	-2.8	-2.8	-1.3	-0.8	0.2	-2.2	-1.2	-3.6	-2.2	-3.0	-0.8	-1.4
Ever had hysterectomy (womb removed)	3.7	4.2	7.9	2.4	0.8	2.7	2.2	1.9	2.7	2.8	1.7	2.5	1.5	1.4	1.9	-1.8	1.9	1.8	1.5	1.4	2.2	2.8	1.4
Fractured/broken bones in last 5 years	3.6	4.6	9.6	2.8	1.0	3.0	2.2	2.5	1.7	3.1	2.6	2.0	1.8	0.9	2.2	0.4	2.1	1.4	2.1	2.5	2.5	2.9	0.9
Time employed in main current job	3.5	4.0	13.6	-1.7	-1.4	-1.9	-2.2	-0.7	-2.2	-2.3	-0.9	-2.1	-2.2	-1.1	-1.9	1.0	-2.5	-2.5	-1.7	-1.8	-2.5	-3.7	-1.6
Osteoarthritis (self-reported)	3.4	4.4	7.9	2.8	2.4	2.4	2.1	1.8	2.0	2.6	0.9	1.9	2.4	1.7	2.2	-0.7	2.2	1.5	1.6	2.6	2.2	2.3	2.2
Ever used hormone-replacement therapy (HRT)	3.3	4.2	6.8	1.3	2.1	2.0	2.6	1.8	2.4	1.7	1.7	2.5	2.4	2.0	2.6	-1.5	1.7	1.0	2.1	1.5	2.4	2.4	2.5
Diabetes (father)	3.3	4.1	7.1	1.3	2.4	1.8	1.9	1.3	2.3	1.9	1.9	2.1	2.4	2.6	2.3	-2.5	1.8	1.9	1.2	1.1	2.1	1.6	2.7
Current tobacco smoking	3.1	5.0	10.9	2.5	0.9	2.8	2.4	2.0	3.3	3.3	-1.1	2.8	1.7	2.7	1.8	-1.7	2.0	1.9	0.7	1.3	2.5	2.4	2.6
Smoking status: Current	3.0	4.8	11.1	2.3	0.9	2.7	2.3	2.0	3.1	3.3	-1.0	2.6	1.7	2.5	1.5	-1.7	2.2	2.2	0.9	1.3	2.4	2.4	2.4
Average weekly spirits intake	2.9	3.5	9.6	1.4	2.1	2.1	0.9	1.0	1.8	1.5	1.5	1.2	1.7	2.9	3.1	-3.1	1.3	1.5	-0.1	1.2	1.1	2.0	2.8
Medication: Ibuprofen	2.9	3.5	8.5	2.0	1.9	1.5	1.7	1.5	2.1	1.9	0.6	2.0	2.0	2.1	2.9	-0.4	2.3	1.1	0.8	2.7	2.0	1.2	2.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.8	5.8	15.6	-1.9	-1.3	-3.1	-2.9	-2.1	-2.7	-2.2	-1.5	-3.2	-2.3	-1.4	-3.2	2.2	-1.4	-2.1	-2.6	-1.6	-3.1	-4.0	-1.4
Hearing aid user	2.8	3.1	8.1	1.9	1.8	2.6	1.8	1.4	1.7	2.0	0.5	1.6	2.1	0.8	0.8	-1.8	1.5	2.8	2.0	1.4	2.3	1.7	1.0
Smoking status: Previous	2.7	4.0	9.0	1.8	2.1	2.5	2.1	3.0	1.7	1.9	2.1	2.3	2.4	1.2	1.5	-0.6	1.0	1.9	2.6	1.8	2.5	2.1	1.6
Age started oral contraceptive pill	2.7	3.4	6.9	-2.2	-1.7	-1.8	-1.5	-0.1	-2.5	-2.1	1.4	-1.8	-1.8	-1.8	-0.8	2.2	-2.6	-2.5	-0.8	-1.8	-2.0	-1.5	-1.8
Medication: Ibuprofen (e.g. Nurofen)	2.6	3.3	7.7	1.8	2.3	1.1	1.6	1.1	1.9	1.8	0.4	1.7	2.2	2.2	2.6	-0.2	2.4	1.2	0.8	2.8	1.8	1.1	2.4
Medication: Aspirin	2.6	3.4	8.6	-1.9	-2.2	-0.8	-2.6	-1.4	-2.9	-0.9	-0.7	-2.5	-2.1	-1.7	-2.5	0.1	-1.9	-0.2	-0.7	-2.6	-1.9	-1.2	-2.2
Miserableness	2.6	4.5	13.2	1.9	2.5	1.3	1.6	0.5	2.4	2.5	-2.2	1.4	2.2	3.6	2.1	-2.6	3.0	2.3	-0.2	0.7	1.4	-0.5	3.4
Leg fat percentage (right)	2.5	9.1	19.1	2.8	1.8	4.3	3.1	3.5	2.5	2.7	-0.1	3.4	3.0	2.7	3.7	-3.2	1.7	2.9	3.1	2.0	3.8	4.4	2.7
Mood swings	2.5	4.6	9.6	2.0	2.3	1.7	2.0	0.8	2.4	2.9	-1.2	1.9	2.4	2.5	2.4	-2.1	3.1	2.8	1.0	1.9	2.3	0.5	2.3
Falls in the last year	2.3	3.1	9.1	2.1	2.3	1.4	1.0	0.4	0.6	1.0	0.7	0.9	2.1	0.8	3.0	-0.7	2.0	2.1	1.2	2.9	1.6	3.0	0.9
Chronic bronchitis/emphysema (mother)	2.3	2.7	9.0	1.8	1.1	2.4	1.2	1.9	1.2	3.0	1.7	1.8	1.5	0.7	1.5	-0.5	0.5	2.4	1.6	0.7	1.8	1.6	1.0
Schizophrenia vs Biploar Disorder	2.2	2.8	7.1	-1.4	-1.6	-1.4	-2.0	-1.2	-2.0	-2.0	-0.5	-2.0	-2.0	-0.9	-1.1	1.5	-1.9	-2.7	-2.2	-1.3	-2.2	-1.2	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	2.2	7.1	16.7	-2.5	-1.4	-3.8	-2.6	-2.9	-2.5	-2.4	-1.5	-3.2	-2.3	-2.3	-4.1	2.9	-1.3	-2.5	-2.3	-1.6	-3.0	-4.0	-1.8
Body fat percentage	2.2	8.6	19.4	2.2	1.7	4.2	3.0	3.2	2.6	2.1	0.3	3.4	2.9	2.0	3.7	-3.2	1.9	3.3	3.4	1.9	3.7	4.4	2.1
Trunk fat percentage	2.1	8.5	18.5	2.1	1.6	4.2	3.1	3.4	2.7	2.1	0.9	3.5	2.8	1.6	3.6	-3.0	2.0	3.3	3.6	1.9	3.7	4.3	1.8
Medication: Aspirin	2.1	2.7	7.1	-1.9	-1.9	-0.8	-2.3	-1.3	-2.7	-0.8	-0.6	-2.3	-1.9	-1.7	-2.1	0.3	-1.6	-0.3	-0.7	-2.1	-1.7	-1.0	-2.0
Illnesses of father: None of the above (group 1)	2.1	2.6	8.4	-0.9	-1.1	-1.9	-0.9	-1.2	-0.9	-2.0	-2.9	-1.1	-1.4	-1.3	-1.8	2.0	-1.2	-2.0	-1.6	-0.3	-1.5	-2.4	-1.3
Leg fat percentage (left)	2.1	7.5	16.2	2.3	1.6	3.9	2.9	2.9	2.3	2.1	-0.2	3.2	2.7	2.5	3.4	-3.1	1.2	2.9	2.9	1.6	3.6	4.0	2.3
Migraine (self-reported)	2.0	2.5	6.9	-0.7	-2.0	-1.4	-1.4	-1.6	-1.5	-1.7	-1.8	-1.6	-1.9	-0.6	-0.0	0.6	-2.0	-1.6	-2.0	-1.5	-1.5	-2.6	-1.3
Medication: Gliclazide	2.0	2.2	8.1	-2.8	-1.4	-1.6	-1.3	-2.1	-0.8	-1.6	-1.4	-1.1	-1.5	-1.6	-1.3	0.9	-1.3	-0.1	-0.5	-2.3	-1.3	-0.1	-1.8
Major Depression (MDD)	1.8	2.2	7.4	2.0	0.9	2.1	0.3	1.7	1.1	0.8	0.9	0.8	1.1	-0.6	2.0	0.2	1.2	1.9	2.1	2.4	1.0	2.7	-0.3
Leg fat mass (right)	1.8	6.9	19.2	1.8	1.1	3.7	2.8	2.5	2.5	1.9	-0.6	3.2	2.3	1.9	3.1	-3.4	1.4	3.1	2.7	1.0	3.4	4.4	1.8
Commuting to job workplace: Car/motor vehicle	1.8	2.1	6.4	2.3	0.4	2.5	2.0	0.5	2.3	2.1	1.5	2.2	1.0	0.3	1.3	0.1	0.6	0.8	1.2	0.8	1.7	0.8	0.4
Average weekly red wine intake	1.8	2.6	13.7	0.6	2.0	2.0	1.5	1.9	1.3	-0.2	3.7	1.6	2.0	0.1	1.2	-0.5	0.6	2.0	2.2	1.6	1.7	-0.2	0.7
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	4.0	1.0	1.3	1.1	1.2	0.9	0.9	1.6	-0.9	1.3	1.5	0.4	1.8	-1.7	1.6	1.8	2.0	1.3	1.6	1.8	0.9
Alzheimer’s Disease (in father)	1.7	1.8	3.8	-1.7	-0.0	-2.0	-1.6	-1.6	-1.8	-1.8	-0.1	-1.8	-0.6	-1.9	-1.7	1.9	-0.5	0.1	-0.2	0.1	-1.1	-1.2	-1.6
Hypothyroidism (self reported)	1.7	3.8	10.0	2.7	1.7	2.2	2.0	1.9	1.8	1.7	2.7	1.6	1.8	3.2	2.9	-0.9	0.5	0.8	1.2	0.3	1.9	1.2	2.7
Waist circumference	1.7	6.2	24.2	2.0	0.2	3.5	2.5	1.7	2.4	1.9	0.8	3.0	1.6	0.6	3.9	-2.5	1.7	3.1	2.9	0.9	3.0	4.9	0.5
Arm fat percentage (right)	1.7	6.9	16.9	2.0	1.5	4.1	2.4	2.8	2.3	2.1	-0.4	2.9	2.4	2.0	3.5	-3.1	1.6	3.1	2.9	1.6	3.1	3.8	1.9
Number of live births	1.7	2.3	5.2	1.7	1.6	1.8	2.1	0.6	2.3	1.5	0.2	2.0	1.7	2.1	1.8	-0.3	0.8	0.6	0.9	1.4	1.8	0.1	2.0
Forced vital capacity (FVC), Best measure	1.7	6.1	12.8	-2.0	-1.5	-3.6	-2.4	-2.8	-2.0	-2.2	-0.2	-2.7	-2.3	-2.8	-3.3	3.4	-1.1	-2.5	-2.0	-1.4	-2.9	-3.6	-2.1
Arm fat percentage (left)	1.7	6.8	16.3	2.0	1.5	4.0	2.4	3.0	2.2	2.0	-0.2	2.9	2.4	2.2	3.6	-3.0	1.4	3.0	2.7	1.5	3.1	3.8	2.1
Lung cancer (father)	1.6	1.9	5.9	0.8	-0.2	1.3	1.6	0.9	1.8	1.8	-1.5	2.1	0.7	-1.0	-0.1	-0.7	1.1	2.4	1.5	0.3	1.8	2.0	-1.0
Whole body fat mass	1.6	6.9	18.0	1.5	1.1	3.8	2.8	2.6	2.6	1.7	0.1	3.2	2.3	1.2	3.3	-3.2	1.7	3.5	3.2	1.1	3.4	4.2	1.2
Alcohol intake frequency.	1.6	3.6	11.0	-0.3	-2.8	-1.8	-2.0	-3.3	-1.2	-1.4	-2.9	-1.8	-2.6	-1.5	0.0	-0.3	-1.4	-1.2	-2.2	-2.4	-1.9	-0.0	-2.2
Friendships satisfaction	1.6	2.0	6.3	1.5	1.5	1.2	0.7	1.8	0.6	1.5	1.9	0.8	1.4	-0.3	2.0	-0.1	2.5	1.5	1.8	2.1	1.1	0.7	0.4
Risk taking	1.6	2.3	12.0	1.5	0.0	1.8	1.0	0.8	1.2	1.7	0.6	1.5	0.7	-0.2	2.0	-2.4	0.4	2.0	1.6	-0.3	1.4	3.5	0.0
Blood Eosinophil Count	1.5	11.3	26.3	3.2	2.6	3.3	3.2	1.6	4.2	4.2	-1.5	3.9	3.4	0.1	2.6	-3.4	4.8	5.1	3.8	2.4	3.5	4.2	1.7
Frequency of depressed mood in last 2 weeks	1.5	2.0	6.4	2.2	1.0	1.6	0.9	0.2	2.1	2.5	-2.3	1.3	1.1	1.1	1.1	-0.8	1.5	2.0	0.5	1.1	1.1	0.1	0.8
Trunk fat mass	1.5	6.7	16.2	1.4	1.1	3.7	2.8	2.6	2.6	1.6	0.6	3.3	2.3	1.1	3.1	-3.1	1.8	3.3	3.3	1.1	3.3	4.0	1.2
Depression (self-reported)	1.5	1.7	6.1	1.0	1.3	0.3	1.6	0.7	2.0	1.6	-1.0	1.4	1.4	0.9	0.7	-0.7	2.5	1.8	1.4	0.3	1.5	0.4	1.2
Birth weight of first child	1.5	2.6	6.6	-2.2	-1.3	-2.6	-1.2	-1.8	-1.6	-2.0	-2.4	-1.6	-1.5	-1.9	-2.4	0.8	-0.2	-1.5	-0.8	-0.6	-1.4	-0.3	-1.7
Ever highly irritable/argumentative for 2 days	1.5	1.8	4.9	2.2	1.4	1.5	0.4	0.5	1.4	2.0	-0.6	0.9	1.0	1.4	2.0	-0.9	1.9	1.2	-0.3	1.3	0.5	1.2	1.5
Mean time to correctly identify matches	1.5	2.9	9.3	1.0	1.1	1.7	1.9	2.1	1.3	1.4	2.3	1.8	1.8	0.3	1.1	-2.0	0.7	1.7	2.5	0.9	2.3	3.0	0.5
Leg fat mass (left)	1.5	6.0	17.5	1.5	1.0	3.4	2.6	2.1	2.4	1.5	-0.5	3.0	2.1	1.6	3.0	-3.2	1.2	3.2	2.7	0.8	3.2	4.2	1.5
HbA1C	1.4	1.6	2.9	1.7	0.9	1.4	1.6	1.7	1.4	1.2	0.6	1.7	1.3	0.2	1.5	-1.3	-0.1	1.3	1.5	0.1	1.7	1.1	0.1
Relative age voice broke	1.4	2.1	5.5	-1.7	-0.4	-2.3	-1.4	-1.6	-1.6	-1.2	1.7	-1.7	-1.0	-0.1	-1.0	2.0	-1.2	-2.1	-2.1	0.2	-1.4	-0.8	-0.3
Noisy workplace	1.4	1.7	6.2	1.2	0.9	1.6	0.9	1.1	1.1	1.8	-1.2	1.4	1.1	1.1	0.5	-2.1	0.7	1.5	0.8	0.3	1.3	2.5	1.0
Prospective memory result	1.4	1.7	6.0	-0.8	-1.9	0.3	-0.6	1.2	-1.1	-1.3	0.3	-0.7	-1.4	-2.4	-1.7	1.7	-1.5	-0.9	0.6	-0.8	-0.6	-1.2	-2.4
Breast Cancer	1.3	3.1	8.2	1.7	1.2	2.5	1.6	2.2	0.4	1.3	2.9	1.4	1.8	1.6	2.8	-0.4	-0.2	0.8	2.0	1.6	2.1	2.1	1.3
Triglycerides	1.3	2.1	4.7	1.9	1.0	2.0	1.6	1.7	1.4	1.7	0.3	1.8	1.4	1.1	2.2	-1.5	0.3	0.9	1.0	1.1	1.5	1.1	1.4
Medication: Co-codamol	1.3	1.6	5.6	-0.5	-1.3	-0.8	-1.3	-0.3	-1.3	-0.8	-2.4	-1.3	-1.3	-1.0	-1.8	0.8	-1.2	-1.0	-1.1	-1.2	-1.3	-1.5	-1.1
Taking other prescription medications	1.3	1.9	9.8	3.1	-0.6	2.1	0.7	0.5	1.2	1.6	-0.4	0.9	0.2	0.5	3.0	-0.7	0.4	0.6	0.6	0.5	0.9	2.6	0.2
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	4.6	1.5	1.7	1.6	0.5	0.5	0.8	1.7	1.1	0.4	1.4	1.3	2.1	-0.8	1.4	1.5	0.2	1.7	0.9	0.8	1.4
Hip circumference	1.3	5.4	14.8	0.7	1.8	2.8	2.1	1.7	1.8	1.1	0.9	2.4	2.4	2.3	2.6	-3.9	1.6	3.2	2.6	0.6	2.7	3.6	2.3
Number of full sisters	1.3	1.6	8.1	1.3	0.2	2.0	0.7	0.6	1.4	2.1	1.3	1.1	0.4	1.8	2.9	-0.1	-0.4	0.3	-0.7	-0.2	0.4	0.8	1.6
Arm fat mass (left)	1.3	5.2	13.7	1.1	0.8	3.4	2.2	2.1	2.2	1.5	-0.5	2.8	1.9	1.2	3.0	-3.1	1.4	3.1	2.6	0.7	2.8	3.7	1.1
Waist Hip Ratio (WHR)	1.2	5.2	19.3	3.3	-1.4	2.5	1.7	1.3	2.2	1.9	1.6	2.4	0.2	-2.5	4.4	1.3	1.8	1.1	2.2	2.3	1.9	3.7	-2.1
Lung FVC	1.2	6.1	16.0	-2.0	-1.6	-3.6	-2.2	-4.0	-1.2	-1.4	-1.5	-2.4	-2.5	-2.1	-3.7	2.6	-0.9	-1.9	-3.0	-2.3	-3.0	-2.7	-1.8
Townsend deprivation index at recruitment	1.2	1.6	4.2	1.8	-0.1	2.0	1.1	1.5	1.9	2.0	-0.8	1.6	0.5	1.1	1.9	-1.3	0.4	1.1	-0.2	-0.0	0.8	1.1	0.9
Supplements: Glucosamine	1.2	1.6	6.4	0.9	1.2	1.1	2.0	-0.0	1.1	1.2	1.2	1.3	1.6	0.2	0.4	1.4	0.7	-0.4	1.4	2.5	1.8	1.0	0.7
Allergy	1.2	2.7	7.7	-2.8	-0.4	-2.3	-1.5	-1.2	-1.8	-1.9	-0.6	-1.8	-1.3	-0.5	-2.7	0.1	-1.3	-1.1	-1.6	-2.3	-1.9	-1.7	-0.8
Medication: Simvastatin	1.2	1.7	6.1	-0.7	-2.0	-0.1	-1.4	-0.8	-1.4	-0.4	-0.7	-1.3	-1.5	-1.7	-0.7	-1.4	-1.2	1.1	0.4	-2.4	-0.7	0.3	-2.5
Father’s age at death	1.2	1.6	8.7	-0.4	1.9	1.2	0.9	1.0	0.8	-0.4	2.9	0.8	1.3	2.0	1.5	-1.1	0.4	0.4	0.4	0.4	0.7	0.2	2.0
Age at first live birth	1.2	2.0	7.1	-1.1	0.3	-2.0	-1.8	-0.9	-2.1	-0.9	-0.7	-2.2	-0.6	0.6	-1.8	1.2	-0.4	-0.9	-2.0	-0.4	-1.7	-2.7	0.7
Emphysema/chronic bronchitis	1.2	1.4	3.5	0.6	0.0	1.5	1.6	1.2	1.6	1.4	1.1	1.6	1.0	0.5	1.1	-0.8	0.0	1.4	1.9	-0.1	1.6	1.0	0.6
Wears glasses or contact lenses	1.2	1.4	5.1	-2.0	-0.1	-0.7	-1.3	0.1	-2.0	-1.7	0.1	-1.7	-0.6	-0.9	-1.1	1.2	-0.6	-0.7	0.1	-0.4	-1.2	-2.3	-0.9
Alzheimer’s Disease (including proxy)	1.1	1.6	7.0	-0.9	-1.1	-1.3	-0.9	-0.8	-0.9	-1.0	-1.2	-0.9	-1.0	-2.7	-2.0	1.3	-0.7	-0.1	0.2	0.1	-0.6	-1.4	-2.5
Ovarian Cancer	1.1	1.4	6.4	2.3	0.1	1.6	0.1	0.8	-0.0	1.3	2.5	0.0	0.4	0.3	1.8	-0.2	0.8	0.7	0.4	0.9	0.6	2.2	0.4
Coronary Artery Disease (CAD)	1.1	1.4	5.7	1.8	-0.3	1.0	0.7	1.9	0.4	0.5	-0.1	0.7	0.4	0.2	2.0	-0.5	1.3	0.4	1.3	1.4	1.3	2.4	0.6
Rheumatoid Arthritis	1.1	1.5	4.9	1.1	0.9	1.0	2.2	0.9	1.9	1.3	-0.5	1.7	1.4	1.8	-0.3	-1.0	0.7	0.2	0.9	0.7	1.8	0.1	1.6
Ulcerative Colitis	1.1	1.6	11.4	0.3	-0.8	-1.0	-1.0	-1.5	-0.7	0.2	1.1	-1.1	-0.9	-2.1	-1.0	3.4	0.6	-0.8	-0.6	1.3	-0.9	0.2	-1.3
Systolic blood pressure, automated reading	1.1	3.2	5.8	1.7	1.4	2.4	1.9	1.8	1.4	2.0	0.2	2.1	2.0	1.8	1.9	-1.8	0.5	2.1	2.1	1.0	2.3	2.0	1.7
Medication: Metformin	1.1	1.6	6.8	0.5	0.5	1.5	0.7	0.3	0.6	1.2	0.3	0.9	0.9	0.7	2.1	-2.2	-0.1	2.6	1.1	-1.0	1.2	2.0	0.4
Diabetes (mother)	1.1	1.4	5.2	0.9	0.1	1.5	1.5	1.4	1.0	1.3	1.4	1.5	0.9	-0.4	1.1	-0.3	0.5	0.5	1.5	1.1	1.5	2.3	-0.1
Fed-up feelings	1.1	2.0	10.0	1.5	1.3	0.8	0.9	0.3	1.4	1.9	-3.2	0.7	1.2	1.8	1.4	-1.0	2.0	1.4	-0.3	1.1	0.8	-0.4	1.5
Pulse wave Arterial Stiffness index	1.1	1.2	3.9	-1.0	-1.7	-0.7	-1.1	-1.1	-0.5	0.5	-2.0	-0.6	-1.3	-1.9	-1.5	1.3	0.1	-0.5	-0.5	-0.4	-0.7	0.2	-1.6
Arm fat mass (right)	1.1	4.7	12.7	1.0	0.7	3.3	2.1	1.9	2.1	1.4	-0.7	2.7	1.7	1.1	2.7	-3.1	1.3	3.1	2.5	0.5	2.7	3.6	1.0
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	5.6	-0.3	-1.2	-0.2	-1.3	1.0	-1.4	-0.6	0.3	-1.2	-1.2	0.4	-0.5	1.9	-1.2	-2.4	-1.4	-0.1	-1.1	-2.1	0.2
Blood clot in the leg (DVT)	1.1	1.5	3.2	1.4	0.7	1.3	1.8	0.8	1.7	1.8	-0.9	1.5	1.2	0.1	-0.6	-0.0	1.6	1.2	1.4	1.6	1.4	0.3	0.3
Suffer from ‘nerves’	1.1	1.8	4.8	1.1	1.1	0.2	1.5	0.4	1.7	1.9	-1.8	1.4	1.4	1.1	1.1	-0.2	2.2	1.7	0.9	1.5	1.5	0.5	1.1
Supplements: Vitamin C	1.1	1.2	5.1	-0.7	-0.8	-0.8	-0.6	-0.6	-0.8	-1.6	0.9	-0.9	-1.1	-0.6	-1.1	1.1	-1.5	-1.6	-0.8	-0.9	-1.1	-2.2	-0.9
Long-standing illness, disability or infirmity	1.1	1.6	7.6	1.6	0.2	1.7	0.8	0.6	0.5	1.1	1.2	1.0	0.8	-0.4	2.8	0.5	0.6	1.5	1.5	1.0	1.3	2.4	-0.1
Number of self-reported non-cancer illnesses	1.1	1.9	9.6	2.5	-0.9	2.0	0.8	1.4	0.5	1.3	1.0	0.8	0.2	-0.3	3.1	0.2	0.9	1.4	1.6	0.8	1.3	1.9	-0.5
HDL Cholesterol	1.0	1.6	4.3	-1.8	-0.3	-0.5	-1.3	-0.3	-1.7	-1.0	1.8	-1.5	-0.7	0.9	-1.2	1.7	-1.9	-1.1	-1.0	-1.2	-0.6	-2.1	0.4
Heel T-Score	1.0	7.7	16.2	-2.9	-4.0	-3.1	-2.9	-2.5	-2.5	-3.5	-2.8	-2.7	-3.7	-1.7	-1.8	-0.5	-2.5	-1.9	-3.1	-3.5	-3.0	-1.3	-3.1
Lung FEV1/FVC ratio	1.0	5.0	16.8	-2.9	-0.4	-1.3	-1.8	-1.2	-2.2	-2.4	-3.2	-2.3	-1.1	1.9	-4.1	-1.2	-2.9	-1.7	-2.1	-2.0	-1.7	-3.7	0.8
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	5.7	-1.4	-1.7	-2.4	-1.1	-1.0	-1.2	-1.2	-2.2	-1.1	-1.6	-0.2	-2.0	-0.7	-1.2	-1.2	-1.5	-2.4	-1.3	-1.2	-0.9
Chronic bronchitis/emphysema (father)	1.0	1.2	6.5	1.2	-0.5	1.2	0.2	1.9	-0.6	0.8	1.3	0.3	0.0	-1.2	1.4	-0.2	-0.6	-0.0	1.4	0.6	0.7	2.5	-0.9
Hearing difficulty/problems with background noise	1.0	1.6	4.8	1.9	1.0	0.4	1.8	1.0	1.5	1.5	-0.3	1.5	1.5	0.3	2.2	0.2	1.3	0.4	1.0	1.1	1.6	1.4	0.8
Had menopause	1.0	1.2	7.6	-2.8	-0.8	-0.6	-0.6	-0.1	-1.5	-2.0	1.1	-0.9	-0.7	-0.4	-1.3	-0.0	-1.4	-1.3	0.1	-0.8	-0.5	-0.2	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.4	6.9	-1.7	-1.9	-2.6	-1.3	-1.3	-1.7	-1.5	-1.4	-1.4	-1.7	-0.6	-2.0	-0.0	-1.4	-1.2	-1.2	-2.2	-1.3	-1.1	-1.3
Number of full brothers	1.0	1.2	3.8	1.6	0.6	1.6	1.4	1.5	0.8	1.3	0.1	1.1	0.9	-0.2	1.6	-0.3	0.5	0.6	1.0	1.0	1.1	2.0	0.1
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	3.1	-0.2	-1.3	-1.4	-1.4	-0.9	-1.5	-1.1	-1.1	-1.8	-1.5	-1.1	-1.5	1.5	-0.6	-1.7	-1.0	-0.2	-1.6	-1.3	-1.1
Financial situation satisfaction	1.0	1.3	6.6	-0.2	-0.7	-0.8	-0.7	-0.1	-1.1	-0.5	-2.6	-1.0	-0.8	-1.6	-2.3	0.2	-0.2	0.3	0.3	-0.8	-0.7	-1.4	-1.4
Irritability	1.0	1.8	6.2	1.6	0.9	0.5	1.4	1.1	1.4	1.5	0.2	1.0	1.2	0.9	1.0	0.5	2.5	1.2	0.9	2.4	1.5	1.6	1.0
Type 2 Diabetes (T2D) (2012)	0.9	1.1	4.6	1.1	-1.4	1.6	1.0	2.1	0.1	1.3	-0.8	1.0	-0.2	0.1	1.0	-0.5	-0.7	-0.6	1.4	-0.1	1.7	0.6	0.0
Chronotype (morning person)	0.9	2.1	7.7	0.9	1.0	1.7	1.0	1.8	0.4	1.8	2.8	1.0	1.4	0.4	1.5	-1.9	1.0	2.0	2.0	1.0	1.5	1.2	0.5
Vitamin and mineral supplements	0.9	1.2	4.1	0.7	1.1	0.8	0.6	0.8	0.8	0.9	-0.5	0.9	1.1	1.4	1.3	-2.0	1.1	1.0	0.8	0.7	0.8	1.7	1.6
Body mass index (BMI)	0.9	3.7	11.5	0.7	0.4	3.0	1.5	1.4	1.5	1.4	-1.6	2.1	1.3	1.8	2.0	-3.4	0.6	2.8	1.7	-0.2	2.3	3.4	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	4.4	1.6	-0.0	1.5	0.4	0.5	0.5	1.9	0.9	0.6	0.5	-0.6	1.2	1.2	0.6	1.6	0.9	1.3	0.9	2.1	-0.2
Pulse wave peak to peak time	0.9	1.0	5.1	0.9	1.6	0.5	1.0	0.9	0.4	-0.7	2.3	0.4	1.2	1.6	1.4	-1.1	-0.0	0.4	0.4	0.4	0.6	-0.3	1.3
Shortness of breath walking on level ground	0.9	1.1	7.2	-1.3	-0.9	-1.0	-1.0	-1.4	-0.5	-0.8	-2.7	-0.8	-0.9	-1.1	-1.0	-0.1	-0.1	0.1	-0.4	-0.6	-0.8	-0.5	-1.1
Overall health rating	0.9	2.0	7.5	2.7	-0.7	2.2	0.4	1.0	1.0	1.8	-1.5	0.9	0.2	-1.4	1.7	0.6	0.9	1.8	1.3	1.5	1.0	1.9	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	6.1	-0.4	-0.3	-0.7	-1.4	-1.2	-1.2	-0.2	-2.5	-1.3	-0.7	-0.3	-0.2	0.9	0.4	-0.9	-1.4	0.5	-1.3	-1.0	-0.2
Guilty feelings	0.9	1.4	8.9	1.3	0.9	1.3	0.3	1.4	-0.1	0.8	0.6	0.1	0.9	2.3	3.0	-1.1	0.4	0.6	0.2	1.0	0.8	0.1	1.7
Number of operations (self-reported)	0.9	1.3	4.5	2.1	-0.2	1.8	1.1	-0.3	1.7	1.7	0.1	1.2	0.3	0.1	2.0	0.5	1.1	0.5	-0.1	1.4	0.8	1.2	0.1
Unable to work because of sickness or disability	0.9	1.2	8.2	2.9	-1.1	1.4	0.6	0.8	1.0	1.4	-0.9	1.1	-0.3	-1.1	1.2	0.2	-0.3	0.9	0.4	-0.3	0.6	0.9	-1.3
Intelligence (Savage-Jansen 2018)	0.8	2.4	8.6	-2.0	-0.7	-2.9	-2.1	-1.3	-2.3	-1.6	-0.4	-1.9	-1.3	-1.3	-1.9	1.4	-0.8	-1.4	-1.2	-0.7	-1.8	-0.1	-0.9
Irritable Bowel Disease (IBD)	0.8	1.8	12.3	0.1	-0.2	-1.8	-1.3	-1.0	-1.1	-0.6	0.5	-1.6	-0.6	-1.7	-0.9	3.5	1.5	-0.8	-0.9	1.6	-1.2	-1.3	-0.9
Blood Platelet Count	0.8	8.8	38.4	3.0	-2.4	0.4	0.0	0.9	0.4	3.1	-3.9	0.8	-0.9	-6.2	-0.8	5.1	3.6	-0.0	2.3	4.0	0.5	4.7	-3.5
BMI	0.8	4.9	17.9	1.4	0.7	3.2	1.5	1.8	1.9	1.6	-1.8	2.3	1.5	0.9	2.8	-3.2	1.5	3.5	1.9	0.9	2.4	4.2	0.9
Type 2 Diabetes (T2D) (2018)	0.8	1.4	8.2	1.1	0.1	1.0	0.3	0.6	0.4	1.5	-0.3	0.7	0.5	-0.2	2.8	-0.4	0.8	1.8	0.9	0.8	0.7	2.9	-0.1
Pack years adult smoking proportion	0.8	1.2	5.1	0.7	-1.2	0.8	1.3	-0.1	1.8	1.8	-2.2	1.6	-0.1	-0.3	-0.8	-0.2	-0.2	0.6	0.2	-0.9	1.0	1.2	-0.5
Impedance of leg (right)	0.8	3.6	12.7	3.3	1.6	1.3	1.9	2.4	1.0	1.6	3.1	1.3	1.9	-0.2	1.6	1.4	1.8	-0.2	2.2	3.6	1.7	1.0	0.7
Age when periods started (menarche)	0.8	1.9	6.0	0.6	2.1	0.6	1.5	0.3	1.7	1.4	0.9	1.6	1.9	-0.4	-0.5	1.2	1.6	1.1	1.5	2.5	1.6	1.5	0.3
Multivitamins +/- minerals	0.8	1.1	3.4	-1.0	-1.2	-0.6	-0.6	-0.7	-0.8	-0.4	-0.3	-0.6	-1.0	-1.8	-1.4	1.7	-0.8	-0.6	-0.7	-0.5	-0.5	-1.2	-1.8
Stomach or abdominal pain in last month	0.8	1.0	2.9	1.7	-1.1	0.8	0.5	0.7	1.0	1.1	-1.4	0.7	-0.3	-0.5	1.4	1.2	0.8	0.1	0.1	1.7	0.7	1.4	-0.7
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	9.2	-1.7	-0.2	-2.6	-1.4	-2.1	-1.3	-1.5	-1.0	-1.8	-1.1	-1.6	-3.0	1.6	-0.2	-1.1	-1.0	-0.7	-1.7	-2.4	-0.9
Mouth/teeth dental problems: Dentures	0.8	1.3	4.2	0.8	0.4	1.5	1.0	1.2	0.4	1.3	1.1	1.0	0.9	0.0	1.7	-0.7	0.6	1.4	1.7	0.7	1.5	2.1	-0.2
Medication: Lansoprazole	0.8	0.9	4.2	0.2	-1.6	-0.5	-0.7	-1.0	-0.5	-0.9	-2.1	-0.5	-1.2	-1.1	0.1	0.0	-1.2	-0.6	-0.3	-1.2	-0.7	0.1	-1.3
Exposure to tobacco smoke at home	0.8	0.9	4.5	0.6	0.9	1.4	0.4	1.1	0.7	1.1	-0.1	0.6	0.9	0.7	1.1	-2.1	0.9	1.7	0.4	-0.1	0.7	0.0	0.7
Number of children fathered	0.8	0.9	2.4	0.8	0.5	1.4	0.9	1.2	1.1	0.9	0.7	1.3	0.8	0.1	0.3	-1.6	0.2	1.5	0.9	-0.2	1.0	1.4	0.2
Age at last live birth	0.8	1.2	4.8	-1.0	0.8	-1.5	-0.7	-1.2	-0.8	-0.4	-1.7	-0.9	0.0	1.0	-1.2	-0.1	-0.7	0.2	-1.6	-1.2	-0.8	-2.2	0.9
Alcohol drinker status: Never	0.8	1.0	6.8	0.5	-1.2	-0.7	-0.9	-2.6	-0.1	0.1	-1.0	-0.6	-0.9	-1.9	0.1	0.8	-0.1	0.2	-0.5	-0.2	-0.7	0.2	-1.8
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.3	1.2	0.6	1.1	1.3	0.5	1.4	1.5	-0.9	1.2	0.9	0.1	-0.6	0.0	1.5	1.1	1.0	1.4	1.0	0.1	0.2
Depressed Affect (Nagel 2018)	0.7	1.4	5.2	1.4	0.8	0.7	1.0	-0.0	1.5	1.7	-2.3	0.7	0.9	1.1	1.4	-0.2	2.2	1.0	0.0	1.4	0.8	-0.5	0.9
Body Mass Index (BMI) (2010)	0.7	0.9	3.1	0.5	1.1	0.9	0.3	1.3	0.4	0.5	-0.9	0.5	0.8	0.9	1.6	-1.8	1.3	1.6	0.5	0.3	0.4	-0.2	0.9
Crohns Disease (2012)	0.7	1.1	5.2	0.4	0.9	-1.1	-0.4	1.5	-0.8	-0.8	-1.0	-0.7	0.4	-0.5	0.0	2.3	1.1	-1.1	0.1	2.0	-0.6	-1.3	0.0
Allergy or Eczema	0.7	1.8	5.9	2.4	0.5	1.8	1.6	1.7	1.4	1.3	0.8	1.6	1.2	0.5	2.1	0.7	0.5	0.4	1.4	1.1	1.6	0.6	0.7
Respiratory disease	0.7	1.5	6.8	0.4	-2.2	1.1	-0.5	0.9	0.0	0.5	-1.6	0.4	-1.1	-2.6	0.4	-0.1	-0.2	1.1	1.5	-0.3	0.2	1.2	-2.5
Supplements: Zinc	0.7	0.7	2.9	-1.1	-0.2	-0.6	-0.5	-0.3	-0.1	-1.7	0.1	0.1	-0.5	-0.4	-0.1	-0.7	-1.7	-0.6	-0.5	-1.5	-0.7	-1.6	-0.7
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	4.6	0.9	-0.9	1.2	0.4	-0.1	1.3	1.1	-0.3	0.9	-0.1	0.5	0.6	-2.1	0.5	0.6	0.5	-0.5	0.7	1.3	0.2
Hayfever, allergic rhinitis or eczema	0.7	1.5	5.5	2.4	0.3	1.7	1.0	1.4	1.0	1.1	0.8	1.2	0.9	0.3	2.3	0.8	0.2	0.0	0.8	2.0	1.3	0.9	0.6
Alcohol usually taken with meals	0.7	1.1	4.7	0.8	1.7	0.4	1.0	0.4	1.0	0.7	2.2	0.8	1.3	-0.1	0.2	0.3	1.5	1.3	1.0	1.2	0.8	1.2	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	3.3	0.7	0.3	1.1	0.7	1.1	1.5	1.8	-1.6	1.1	0.7	0.7	0.6	-1.0	1.3	1.5	0.4	0.5	1.0	0.6	0.7
Diabetes (self-reported)	0.7	1.0	2.4	-1.0	-1.6	-0.2	-1.3	-1.0	-1.1	-0.4	-0.1	-1.0	-1.3	-1.2	1.0	-0.0	-1.3	0.3	-0.4	-1.5	-0.8	0.8	-1.5
Weight	0.7	3.4	11.3	0.3	0.5	2.5	1.9	1.1	1.8	0.7	-0.3	2.3	1.4	0.7	2.2	-3.2	1.1	2.9	2.2	-0.1	2.3	3.4	0.6
Hair/balding pattern: Pattern 3	0.7	1.0	2.7	0.9	1.0	1.4	0.5	1.1	0.4	1.3	-0.2	0.6	1.1	1.2	0.4	-0.1	0.4	0.7	0.8	1.6	1.0	1.6	1.2
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	3.9	2.0	0.4	0.1	1.0	0.4	0.3	1.0	0.0	0.3	0.7	1.2	1.5	1.1	0.9	-0.0	0.4	1.0	1.0	-0.0	1.0
Asthma	0.7	1.3	3.4	1.1	-1.2	1.5	0.1	0.3	1.1	0.9	-0.9	1.1	-0.3	-1.6	1.8	-0.2	1.0	1.3	1.4	0.7	0.7	1.8	-1.4
Loud music exposure frequency	0.7	0.8	2.9	-0.5	-0.6	-0.4	-0.6	-0.3	-0.5	1.2	-1.1	0.1	-0.3	-1.5	-0.6	-0.6	0.7	1.2	1.2	-0.4	0.1	1.7	-1.3
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	4.4	1.8	0.3	1.0	1.0	1.1	0.5	0.6	1.9	0.6	0.6	2.1	1.9	-1.2	-0.4	0.0	0.7	-0.7	0.9	1.4	1.5
Worry too long after embarrassment	0.7	1.1	3.6	1.2	0.7	0.7	0.7	0.9	0.2	0.9	-0.5	0.4	1.1	0.1	1.3	-1.1	1.9	1.6	1.8	1.6	1.2	-0.3	0.2
Chest pain or discomfort	0.7	1.0	3.6	0.9	-0.8	0.6	-0.3	-0.9	0.5	0.6	-1.7	0.2	-0.3	-1.1	1.3	-1.4	0.9	1.8	0.5	-0.3	0.2	1.9	-0.9
Mineral and other dietary supplements	0.7	1.0	6.1	0.4	-0.1	0.1	0.4	0.4	0.6	0.3	-2.0	0.7	0.3	0.9	1.5	-2.5	0.6	1.1	0.4	-0.4	0.6	1.3	0.7
Osteoporosis (self-reported)	0.7	0.9	4.0	-0.1	-0.9	0.3	-1.2	-1.0	-0.9	-0.2	0.7	-1.1	-1.0	-1.4	-1.5	2.0	-0.8	-0.4	-0.5	0.0	-0.8	-0.4	-1.1
Supplements: Fish oil (including cod liver oil)	0.7	1.0	7.4	-0.2	1.2	-0.1	0.1	-0.2	-0.2	-0.1	2.7	-0.6	0.5	-0.3	-1.0	2.2	0.3	-0.7	-0.1	1.2	-0.2	-1.4	-0.0
Supplements: Calcium	0.7	0.8	2.9	0.0	0.3	0.3	-0.1	0.3	-0.3	-1.0	1.5	-0.3	-0.2	1.1	-0.3	0.7	-1.7	-1.4	-1.3	-0.8	-0.6	-1.0	1.0
Alcohol drinker status: Previous	0.7	0.7	2.8	-0.0	-1.0	-0.4	-1.0	-0.8	-0.5	-0.9	0.7	-0.5	-1.0	-1.2	1.7	0.3	-1.0	-0.0	-0.5	-1.0	-0.9	0.6	-1.3
Pack years of smoking	0.7	1.0	4.7	0.5	-1.1	0.7	1.1	-0.1	1.4	1.6	-2.2	1.4	-0.2	-0.5	-1.1	-0.1	-0.6	0.5	0.2	-1.0	0.8	0.9	-0.7
Depression (Nagel 2018)	0.6	0.9	2.4	1.4	0.2	1.0	0.2	0.6	1.0	1.2	-1.6	0.6	0.4	-0.0	1.5	-0.6	1.2	1.5	1.1	0.7	0.7	0.0	-0.3
Crohns Disease (2017)	0.6	1.3	6.9	0.1	0.1	-1.7	-1.2	0.0	-0.9	-0.9	-0.6	-1.4	-0.4	-1.1	-0.3	2.6	1.5	-0.8	-0.9	1.3	-1.2	-1.7	-0.6
Ulcerative Colitis (UC)	0.6	1.1	8.7	0.3	0.0	-1.0	-0.4	-1.4	-0.2	0.4	1.2	-0.7	-0.2	-0.8	-0.6	3.0	1.4	-0.6	-0.9	1.6	-0.6	-0.5	-0.0
Reaction Time	0.6	1.2	6.2	0.8	0.0	1.1	0.7	1.5	0.7	0.9	0.6	0.9	0.6	-0.2	0.5	-2.3	-0.2	1.3	1.1	-0.1	1.1	2.5	-0.1
Fasting Glucose	0.6	0.7	2.8	0.2	-0.4	0.6	0.7	0.7	0.7	0.2	-0.6	0.6	0.2	-1.1	0.7	-1.0	0.3	1.7	1.6	0.1	0.8	1.3	-1.2
Cardiovascular Disease	0.6	1.9	6.9	1.4	-2.4	1.1	-1.2	0.1	-0.8	0.8	0.5	-0.7	-1.5	-2.4	1.7	-1.0	0.4	1.4	0.4	-0.7	-0.4	2.2	-2.6
Relative age of first facial hair	0.6	1.2	4.1	0.8	1.2	0.1	0.9	1.6	0.2	0.9	1.9	0.5	1.0	1.3	0.5	1.6	0.4	-1.2	0.3	2.0	0.8	0.1	1.6
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	2.6	-0.6	-0.6	-1.2	-0.9	-1.6	-0.4	-0.0	-0.8	-0.7	-0.8	0.1	-0.3	0.1	0.4	-0.7	-1.6	-0.8	-1.0	-0.6	-0.1
Qualifications: CSEs or equivalent	0.6	0.8	2.6	1.5	0.5	0.9	0.7	-0.1	1.5	0.5	-0.8	1.2	0.5	0.9	1.6	-0.8	0.1	0.8	-0.6	0.1	0.7	0.7	0.7
Serious illness, injury or assault to yourself	0.6	0.7	5.9	1.8	0.6	1.0	0.1	0.3	0.5	-0.5	0.8	0.4	0.4	0.2	2.4	-0.7	0.4	0.9	0.3	0.7	0.3	0.2	-0.1
Hair/balding pattern: Pattern 2	0.6	0.8	5.5	-1.1	-0.1	-0.8	-0.1	-1.2	0.0	-0.5	-0.1	-0.2	-0.4	0.6	-0.4	-1.7	-1.2	-0.2	-1.1	-2.3	-0.5	-0.8	0.1
Had other major operations	0.6	0.8	2.9	1.1	-0.3	0.4	0.3	-1.1	0.6	1.0	0.7	0.3	-0.1	-0.3	1.2	1.4	1.4	-0.6	0.1	1.2	0.1	1.7	0.1
Forced vital capacity (FVC)	0.6	2.1	6.0	-1.1	-0.4	-2.5	-1.2	-2.3	-0.8	-1.3	0.2	-1.4	-1.1	-2.2	-2.2	2.1	0.3	-1.0	-0.7	-0.5	-1.5	-1.8	-1.3
Qualifications: None of the above	0.6	1.3	5.8	1.0	0.1	1.8	0.6	-0.5	1.4	1.6	-1.9	0.8	0.3	0.9	0.8	-2.4	0.7	1.8	-0.1	-0.3	0.8	0.8	0.4
Pain all over the body in last month	0.6	0.7	2.0	0.3	0.6	0.8	0.7	0.3	0.9	0.9	1.1	0.8	0.7	1.3	0.4	-0.6	1.0	1.4	0.7	-0.3	0.9	0.5	1.2
Illnesses of siblings	0.6	0.8	3.5	-0.4	1.6	-0.8	0.2	0.1	0.4	0.4	-1.2	-0.1	0.9	1.4	-0.5	-1.1	1.8	0.3	0.0	0.5	-0.1	0.0	1.9
Impedance of arm (right)	0.6	2.6	10.6	2.3	2.0	1.2	1.0	1.9	0.6	1.0	3.3	0.6	1.6	-0.1	1.9	1.4	1.4	-0.5	1.4	3.2	0.8	-0.2	0.9
Impedance of arm (left)	0.6	2.6	13.1	2.2	1.9	1.0	0.8	2.3	0.3	0.8	3.6	0.5	1.4	0.1	1.9	1.5	1.4	-0.6	1.3	3.0	0.6	-0.3	1.0
Peak expiratory flow (PEF)	0.6	1.4	5.9	-1.4	1.1	-2.0	-0.7	-1.8	-0.6	-0.4	-1.9	-1.1	0.2	0.2	-2.4	1.4	0.5	-0.5	-0.7	0.6	-0.8	-1.1	1.0
Pulse wave reflection index	0.6	0.7	3.8	-0.7	-1.0	-0.5	-0.7	-0.8	-0.9	0.4	-1.9	-0.6	-0.7	-0.7	-1.6	0.3	-0.8	-0.7	0.2	-0.8	-0.3	-0.8	-0.7
Medication: Paracetamol	0.6	1.0	3.6	1.9	1.0	0.9	0.9	0.3	0.8	1.8	-0.3	0.6	1.1	1.4	1.0	-1.0	0.9	0.6	0.1	0.8	1.0	0.4	1.1
Headache pain in last month	0.6	1.0	3.5	-0.0	-0.4	-1.2	-0.4	-1.6	0.4	-0.1	-1.8	-0.3	-0.6	1.9	-0.0	0.1	0.6	-0.5	-1.6	-1.1	-0.5	-1.6	1.0
Medication: Amlodipine	0.6	0.8	2.5	-0.2	-1.3	-0.4	-1.2	0.4	-1.6	-0.6	0.3	-1.2	-0.9	-1.4	-0.5	1.5	-0.6	-0.0	0.3	-0.4	-0.6	-0.8	-1.5
Medication: Seretide 50 evohaler	0.6	0.7	2.7	0.4	-0.4	0.1	0.6	0.6	-0.0	0.3	-0.7	0.3	0.2	-1.3	-0.4	1.6	0.7	0.2	1.6	1.2	0.9	1.5	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	3.1	0.3	1.8	0.2	0.4	0.3	0.2	0.1	0.4	-0.1	1.2	1.3	0.6	-0.9	1.0	0.8	-0.1	1.2	0.4	0.3	1.4
Illnesses of siblings: Diabetes	0.6	0.8	3.5	1.5	0.1	1.1	1.2	0.5	1.2	0.1	1.1	1.1	0.6	0.5	1.9	-0.1	-0.1	0.2	0.2	0.9	1.2	0.0	-0.0
Ever taken oral contraceptive pill	0.6	0.7	2.3	1.0	0.7	0.9	0.7	1.3	1.0	0.6	1.0	0.7	0.6	0.1	1.5	0.2	-0.0	-0.3	0.0	1.3	0.4	1.2	0.8
Medication: Blood pressure	0.6	1.1	4.5	-0.7	-2.0	-0.9	-0.9	-0.9	-0.8	-0.8	-0.1	-0.9	-1.3	-2.1	-0.3	0.3	-0.4	-0.2	0.1	-1.0	-0.6	0.5	-2.1
Medication: Bendroflumethiazide	0.6	0.9	3.5	-0.6	-0.8	-0.8	-1.2	-1.2	-1.2	-0.6	-0.4	-1.4	-0.9	-1.9	-0.2	0.4	0.3	0.6	0.1	-0.7	-1.0	-0.0	-1.7
Medication: Atorvastatin	0.6	0.8	2.7	1.5	0.7	0.9	0.6	0.1	0.6	1.5	-0.4	0.4	0.6	0.5	1.3	-0.6	1.6	0.9	0.8	0.8	0.5	0.7	0.7
Average weekly beer plus cider intake	0.6	0.8	3.1	1.4	-0.4	1.1	0.6	1.3	0.6	0.2	-0.9	0.9	0.0	0.7	1.7	-0.5	-0.7	-0.8	-0.4	0.5	0.5	1.8	0.7
Commuting to job workplace: Cycle	0.6	0.7	3.7	-0.2	-0.2	-1.2	-0.4	0.2	-0.8	-1.1	1.1	-0.4	-0.4	0.3	1.1	1.4	-0.6	-1.2	-0.3	-0.6	-0.6	-1.9	0.0
Vascular/heart problems diagnosed by doctor	0.6	1.7	7.5	-1.7	1.1	-1.7	0.1	-0.4	0.3	-1.8	-0.9	-0.0	0.1	0.6	-1.6	1.9	-0.6	-2.0	-1.5	0.4	-0.7	-2.7	0.9
Blood Red Count	0.5	4.7	17.2	2.9	-1.8	2.9	-0.0	2.7	0.3	2.3	1.4	1.6	-0.3	-4.2	1.6	0.7	0.3	1.9	3.4	1.0	1.3	2.8	-3.2
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	2.6	0.1	-0.3	0.4	0.3	-0.3	1.1	-0.1	-0.0	0.8	-0.0	0.2	1.6	-1.1	-0.4	1.5	0.1	-1.1	0.3	0.7	-0.1
High blood pressure	0.5	1.3	6.2	0.9	-1.5	1.0	-0.3	0.1	-0.7	1.3	0.5	-0.3	-0.5	-0.8	1.3	-1.6	0.4	1.9	1.2	-0.9	0.5	2.5	-1.2
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.4	0.8	0.5	1.1	0.8	-0.0	1.2	0.8	0.2	0.8	0.7	1.2	0.6	-0.4	0.7	0.3	0.4	0.4	0.9	1.2	1.1
Impedance of leg (left)	0.5	2.6	10.3	2.7	1.4	0.7	1.5	1.6	0.6	0.7	3.1	0.9	1.6	-0.6	1.4	2.0	1.2	-0.3	2.0	3.2	1.4	0.2	0.2
Number of incorrect matches in round	0.5	0.9	5.2	-0.6	0.1	1.5	-0.1	2.2	-1.2	0.1	2.3	-0.1	0.2	-0.4	0.1	0.6	-0.9	-0.5	1.3	0.7	0.5	0.2	-0.4
Heart attack	0.5	0.6	1.6	0.1	-1.1	-0.3	-1.0	-1.3	-0.7	0.3	-1.2	-0.8	-0.9	-0.9	-1.0	-0.2	-0.5	0.4	-0.3	-1.1	-0.7	-0.6	-1.0
Alcohol intake versus 10 years previously	0.5	0.7	3.2	0.6	-1.6	-0.7	0.2	-0.9	0.6	1.0	-1.2	0.5	-0.8	-1.0	0.5	0.1	0.5	0.0	-0.2	-0.1	0.2	1.8	-1.1
Worrier / anxious feelings	0.5	0.9	3.5	-0.2	-0.5	-0.9	-0.8	-0.1	-1.1	-0.3	-0.5	-1.0	-0.6	-1.8	-0.8	1.6	0.3	-0.3	0.4	0.4	-0.6	-1.9	-1.8
Medication: Cholesterol lowering	0.5	0.7	3.6	-0.2	-1.5	0.2	-0.5	-0.6	-0.7	0.5	-0.2	-0.5	-1.0	-1.5	-0.4	-0.2	-0.6	0.7	0.1	-1.4	-0.3	0.7	-1.9
Breastfed as a baby	0.5	0.6	3.4	0.1	1.0	0.5	0.7	-0.0	1.0	-0.1	1.8	0.7	0.8	0.5	1.0	-0.5	-0.1	-0.3	-0.3	0.7	0.2	1.1	0.9
Tense / ‘highly strung’	0.5	0.8	1.9	-0.2	-1.3	-1.0	-1.4	-0.6	-0.2	0.2	-1.2	-0.8	-1.3	-0.4	-0.7	-0.1	-0.1	-0.2	-1.1	-1.2	-1.2	-1.3	-0.5
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	3.5	0.4	0.5	-1.2	-0.1	-0.3	-0.5	-0.2	-0.8	-0.3	0.1	0.8	-1.5	1.9	-0.2	-1.9	-0.6	0.9	-0.3	-0.8	0.9
Medication: Ventolin 100micrograms inhaler	0.5	0.7	3.1	-0.0	-1.8	-0.4	-0.7	-1.0	-0.0	0.2	-0.0	-0.1	-1.1	-1.2	-0.2	0.7	-0.1	0.4	-0.1	-1.3	-0.2	1.2	-1.4
High blood pressure (siblings)	0.5	0.7	3.5	1.0	-0.4	1.9	0.2	0.8	0.2	1.2	1.0	0.7	0.2	-0.0	1.4	-0.2	-0.6	1.1	0.5	-0.2	0.6	0.8	-0.3
Qualifications: College or University degree	0.5	1.5	11.9	1.2	0.4	0.5	0.7	2.0	0.5	0.7	3.4	0.9	0.7	-0.4	0.6	0.7	0.9	0.1	1.8	1.4	0.8	1.6	0.3
Medication: Blood pressure	0.5	0.9	2.9	0.3	-1.1	0.4	-1.7	-0.7	-1.7	0.5	-0.5	-1.5	-1.0	-1.0	-0.7	-0.4	-0.6	0.9	-0.6	-0.8	-0.9	0.3	-1.2
Medication: Omeprazole	0.5	0.5	4.4	0.7	-0.0	0.5	-0.4	0.3	-0.3	0.3	-0.4	-0.3	0.0	-0.4	2.1	1.0	1.4	-0.0	0.2	1.3	-0.1	0.3	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.2	-0.2	0.1	-0.1	-0.9	-0.4	-0.6	-1.5	0.7	-0.8	-0.4	0.1	0.2	1.2	-1.3	-0.4	-1.2	-0.3	-0.7	-1.2	0.0
Hypertension (Self-reported)	0.5	1.4	3.9	0.6	-2.0	0.6	-0.9	-0.4	-1.1	0.9	0.6	-0.8	-1.0	-1.4	1.2	-1.2	0.3	1.7	1.0	-1.3	-0.1	1.9	-1.8
Illnesses of father: Heart disease	0.5	0.6	4.3	-1.1	-1.3	-0.0	-0.2	0.2	0.3	-0.0	0.5	0.4	-0.8	0.3	0.1	-1.6	-0.4	0.6	-0.2	-2.1	-0.2	1.0	-0.1
Eye problems/disorders: Cataract	0.5	0.5	2.9	-0.4	0.8	-0.2	0.6	0.4	-0.4	0.1	0.3	0.2	1.0	-0.1	0.2	1.3	0.6	-0.0	1.4	1.7	0.9	0.6	0.4
Asthma (self-reported)	0.5	1.0	2.9	0.8	-1.7	1.2	-0.1	0.2	0.9	0.8	-0.9	0.9	-0.7	-1.7	1.3	0.1	0.8	0.9	1.1	0.2	0.4	1.4	-1.7
Medication: Paracetamol	0.5	0.8	3.5	1.9	0.9	0.6	0.7	0.4	0.6	1.7	-1.1	0.4	0.9	0.9	0.7	0.3	0.9	0.1	-0.2	1.5	0.8	0.1	0.9
Ever had prostate specific antigen (PSA) test	0.5	0.6	2.9	-0.2	0.9	0.1	0.2	-0.6	0.8	-0.2	0.6	0.1	0.3	1.7	-0.2	-0.4	-0.1	-0.5	-1.7	-0.5	-0.2	-1.2	1.3
Cholesterol lowering medication	0.5	0.7	4.6	-0.1	-0.7	0.6	-0.5	-0.2	-0.5	-0.2	0.2	-0.4	-0.3	-0.8	0.3	-2.1	0.1	1.3	1.3	-1.1	0.1	0.7	-1.1
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.7	-0.0	-0.7	-0.3	-1.3	-0.5	-0.8	-0.5	-0.7	-1.1	-0.9	-0.7	1.0	1.2	0.6	-0.5	-0.6	0.1	-1.1	-0.7	-0.7
Heart disease (siblings)	0.5	0.6	3.3	-0.0	-0.6	-0.2	-0.3	-1.0	-0.6	-0.9	-0.5	-0.6	-0.5	-1.4	0.3	1.8	-0.4	-0.8	-0.2	0.7	-0.3	-0.1	-1.4
Impedance of whole body	0.5	2.4	11.9	2.3	1.5	0.6	0.9	1.8	0.3	0.6	3.5	0.4	1.3	-0.5	1.6	2.0	1.3	-0.8	1.5	3.2	0.8	-0.2	0.4
Neuroticism (Nagel 2018)	0.4	1.0	3.2	1.6	0.3	0.9	1.0	0.7	1.3	1.3	-1.1	0.6	0.7	0.3	1.8	0.2	1.6	0.8	0.6	1.6	0.9	-0.3	0.2
Primary Biliary Cirrhosis	0.4	0.5	1.6	1.0	-0.4	1.3	0.7	1.1	0.6	0.7	0.5	0.8	0.3	-0.4	0.2	0.9	-1.1	-0.4	0.2	0.9	0.9	0.6	-0.1
Schizophrenia (2014)	0.4	0.9	3.2	0.7	-1.1	0.4	-0.9	0.4	-1.3	-0.3	1.6	-0.7	-0.8	-1.8	0.8	1.1	-1.0	0.2	0.6	0.1	-0.2	0.7	-1.8
Number of treatments/medications taken	0.4	0.7	2.5	1.6	-1.5	0.6	-0.3	-0.5	0.1	0.7	0.1	-0.1	-0.7	-1.2	1.4	1.1	0.4	0.3	0.4	0.1	0.1	1.1	-1.4
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	1.4	0.5	-1.1	0.4	-0.6	-0.1	-0.6	-0.7	0.9	-0.4	-0.7	-1.0	1.0	0.2	-0.9	0.5	0.8	-1.0	-0.2	0.9	-1.2
Medication for hormone replacement therapy	0.4	0.4	2.4	0.1	-0.3	-0.3	0.2	-0.9	0.5	0.5	1.6	0.2	-0.1	-0.1	-0.1	0.4	1.1	-0.7	-0.0	0.5	0.2	1.4	0.3
Severe depression (siblings)	0.4	0.5	3.1	0.7	0.5	0.1	0.5	-0.2	0.7	0.4	1.4	0.5	0.5	0.9	0.5	0.1	0.6	-0.2	0.3	0.3	0.5	1.8	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	5.3	0.4	0.1	0.5	0.3	0.1	0.7	0.7	-2.3	0.3	0.3	-0.0	0.7	-0.5	0.6	1.1	0.2	0.2	0.4	-0.6	-0.2
Medication: Levothyroxine sodium	0.4	0.7	3.5	1.3	-0.7	0.3	0.5	0.0	0.5	-0.0	1.6	0.3	-0.3	1.2	1.9	0.5	-0.9	-0.6	-0.1	-1.3	0.1	0.4	0.7
Sitting height	0.4	3.2	8.3	-2.5	-2.1	-2.3	-0.8	-0.9	-0.8	-2.3	-0.3	-0.9	-1.9	-2.9	-1.6	2.0	-1.1	-1.7	-0.6	-2.1	-1.6	-1.6	-2.5
Neuroticism score	0.4	0.9	4.4	1.3	0.7	0.2	0.3	0.2	0.6	1.4	-1.7	0.0	0.6	0.6	1.2	0.1	2.1	1.2	-0.1	1.3	0.5	-0.7	0.5
Qualifications: A levels/AS levels or equivalent	0.4	1.0	3.6	0.0	-0.7	-1.3	-1.2	-0.4	-1.4	-0.6	-0.1	-1.3	-0.8	-0.7	-0.8	1.9	-0.6	-1.8	-0.5	0.6	-1.1	-0.9	-0.4
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.7	-0.6	1.3	-0.8	1.0	0.4	1.1	-0.9	-0.6	0.9	1.0	1.2	0.2	-0.2	0.2	-1.0	-0.1	0.9	0.5	-0.4	1.6
Glaucoma (self-reported)	0.4	0.5	1.6	0.2	0.7	0.5	0.8	0.6	0.3	0.5	1.3	0.4	0.7	0.7	0.7	0.1	1.1	-0.2	0.2	1.0	0.6	0.9	0.8
Health satisfaction	0.4	0.5	2.8	0.7	0.2	-0.2	-0.6	-0.0	-0.3	0.2	-1.7	-0.6	-0.0	-0.5	0.5	1.0	1.4	0.3	-0.0	1.3	-0.3	0.5	-0.2
Eye problems/disorders: None of the above	0.4	0.4	3.7	0.5	-0.0	0.5	0.1	-0.3	0.7	0.8	-0.7	0.4	-0.1	0.7	-0.4	-1.9	0.6	0.2	-0.5	-0.7	-0.1	0.7	0.3
Neck or shoulder pain in last month	0.4	0.6	3.8	0.8	-0.9	-0.7	-0.8	-0.8	-0.2	-0.3	-1.9	-0.6	-0.9	-0.5	0.4	1.1	-0.0	-0.4	-1.1	0.0	-0.6	-0.8	-0.7
Heart disease (mother)	0.4	0.4	1.9	1.0	-0.8	1.2	0.1	0.9	-0.0	0.6	1.4	0.2	-0.4	-0.2	0.9	0.1	0.3	-0.2	0.3	-0.1	0.1	1.1	-0.3
Comparative height size at age 10	0.4	2.1	7.1	0.7	0.3	1.4	1.9	1.1	1.7	-0.3	2.7	1.9	1.0	-1.2	0.8	-1.5	1.4	1.6	2.6	-0.0	1.6	0.6	-0.9
Family relationship satisfaction	0.4	0.5	2.3	1.5	-0.1	0.7	-0.2	0.6	-0.2	0.5	1.5	-0.2	-0.0	-0.5	1.5	0.1	0.2	0.5	0.3	0.6	0.0	0.8	-0.5
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.3	0.1	0.3	1.1	0.6	1.1	-0.1	1.1	0.3	0.5	0.7	0.2	-0.9	-0.1	-0.1	0.1	1.1	0.7	0.8	1.0	0.5
Commuting to job workplace: Walk	0.4	0.4	3.1	0.9	0.5	-0.1	-0.1	-0.2	0.2	0.3	-1.2	-0.1	0.4	0.1	0.4	-0.2	0.2	0.7	0.0	1.0	0.2	1.8	0.2
Back pain experienced in last month	0.4	0.6	2.7	1.6	-0.6	1.2	0.6	0.7	0.6	0.7	-0.5	0.7	-0.0	-0.8	0.4	1.0	0.9	0.2	0.2	1.1	0.7	0.6	-0.7
Mother’s age at death	0.4	0.5	3.3	-0.5	0.5	-0.3	0.1	0.6	-0.5	-1.2	1.8	-0.5	0.2	0.3	0.5	0.6	1.2	-0.7	0.1	0.9	-0.1	-0.4	0.5
Illnesses of father: High blood pressure	0.4	0.5	5.0	0.9	0.2	1.3	-0.4	0.4	-0.4	1.0	2.2	-0.3	0.2	0.5	0.5	-0.2	-0.1	0.2	-0.1	0.5	0.3	0.3	0.2
Ever depressed for a whole week	0.4	0.4	2.8	0.2	0.3	1.2	-0.3	0.4	-0.0	0.8	0.5	0.0	0.4	0.4	0.5	-1.4	0.4	1.7	0.3	-0.1	0.6	0.3	0.3
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.8	0.2	-1.1	-0.0	-0.8	-1.1	-0.7	0.5	-1.4	-0.7	-0.7	-0.9	-0.7	-0.3	-0.4	0.5	-0.1	-0.9	-0.5	-0.4	-1.0
Schizophrenia (2018)	0.3	0.5	2.2	0.6	-1.1	0.6	-0.5	0.2	-0.9	0.4	1.5	-0.5	-0.7	-1.0	0.2	0.7	-1.1	0.2	0.3	-0.3	0.0	0.2	-1.2
Prostate Cancer	0.3	0.4	1.5	-0.2	0.7	0.3	0.4	-0.2	0.9	-0.3	0.9	0.4	0.4	1.2	0.4	-0.2	0.8	0.2	-0.5	0.5	0.1	-0.6	1.0
Age at First Birth	0.3	0.4	3.3	0.2	0.7	0.1	0.2	0.8	-0.1	-0.6	1.8	0.3	0.6	-0.2	0.1	-0.3	0.3	0.1	1.0	0.7	0.8	0.8	0.1
Mean Putamen Volume	0.3	0.3	1.3	0.0	0.2	1.1	-0.0	0.2	0.3	0.7	0.7	0.1	0.1	1.2	0.5	-0.0	-0.3	0.1	-0.7	-0.2	0.1	0.8	0.9
LDL Cholesterol	0.3	0.5	2.3	0.9	0.3	1.5	0.6	1.1	1.2	0.2	0.5	1.0	0.4	0.6	1.0	-0.5	-0.1	0.4	0.5	0.2	0.5	-0.2	0.5
Angina	0.3	0.4	2.5	0.1	-0.3	0.8	-0.1	-0.4	0.4	0.5	-0.7	0.4	0.0	-0.3	-0.5	-0.9	0.3	1.6	0.7	-0.7	0.4	0.7	-0.6
High blood pressure (mother)	0.3	0.5	1.7	0.6	-1.3	0.4	-0.8	0.1	-0.3	0.4	-1.3	-0.2	-0.9	0.1	0.7	-0.6	-0.8	-0.4	-1.1	-0.5	-0.4	0.7	-0.1
Leg predicted mass (left)	0.3	1.4	6.1	-1.1	-0.5	1.1	0.9	0.0	1.5	0.1	-1.2	1.4	0.2	0.1	0.4	-2.5	0.6	1.9	0.6	-1.3	0.9	2.2	0.0
Nervous feelings	0.3	0.6	3.2	0.3	-0.2	-0.4	-0.6	-0.6	0.2	-0.1	-1.8	-0.4	-0.4	-0.8	0.5	0.9	0.6	0.2	-0.8	0.2	-0.7	-1.8	-0.8
Mouth/teeth dental problems	0.3	0.4	1.6	-0.9	0.8	-0.9	0.3	-0.9	0.6	-0.6	-0.4	0.3	0.5	0.0	-0.8	-1.3	0.6	0.9	0.4	-0.3	0.1	0.5	0.3
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.5	0.1	-0.8	0.1	-0.6	0.6	-0.5	-0.9	0.8	-0.6	-0.7	-0.2	0.7	0.5	-0.9	-1.2	-1.1	0.1	-0.5	-0.4	-0.4
Hair/balding pattern: Pattern 4	0.3	0.8	2.6	1.6	1.0	1.1	0.4	0.8	0.4	1.0	0.6	0.3	0.8	1.2	1.1	-1.2	0.4	0.7	-0.3	1.0	0.4	-0.3	1.3
Gout (self-reported)	0.3	0.4	1.8	-0.2	-0.4	-0.7	-0.1	-0.3	-0.3	-0.2	-0.9	-0.1	-0.2	1.2	1.4	-0.6	-0.4	-0.1	-0.9	-1.0	-0.2	0.1	0.9
Arm fat-free mass (right)	0.3	1.3	5.1	-1.9	-1.1	0.0	0.5	-0.8	0.7	-0.9	-1.2	0.8	-0.4	-0.7	-0.1	-2.3	0.1	1.6	0.6	-1.8	0.6	1.9	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.5	-0.1	-0.2	-0.0	0.9	0.8	0.0	-0.1	0.5	0.8	0.2	-0.8	0.2	-0.8	0.3	0.1	1.2	-0.1	0.7	1.2	-0.7
Mouth/teeth dental problems: Loose teeth	0.3	0.4	2.1	0.2	-0.9	1.4	0.1	0.9	0.5	-0.1	0.7	0.2	-0.4	-0.2	0.2	1.3	-0.4	-0.3	-0.5	0.2	0.2	0.2	-0.5
Medication for pain relief, constipation, heartburn	0.3	0.5	2.4	-1.5	-0.4	-0.7	0.3	-0.6	0.7	-1.4	0.2	0.4	-0.5	-0.4	-1.1	0.3	-0.7	-0.5	-0.4	-0.9	-0.5	-0.5	-0.2
Angina (self-reported)	0.3	0.5	2.6	0.4	-0.2	0.9	0.0	-0.3	0.5	0.7	-0.8	0.6	0.1	-0.4	-0.5	-0.9	0.5	1.6	0.9	-0.5	0.5	0.6	-0.6
Arm predicted mass (right)	0.3	1.4	5.1	-1.8	-1.0	0.1	0.6	-0.8	0.9	-0.8	-0.8	1.0	-0.2	-0.6	0.2	-2.3	0.3	1.8	0.6	-1.8	0.7	2.3	-0.8
Had major operations	0.3	0.3	1.2	0.5	0.1	-0.4	-0.0	-1.0	0.2	0.3	-0.7	-0.3	-0.1	-0.9	0.6	0.6	1.1	0.5	-0.5	1.0	-0.3	0.1	-0.6
Leg pain on walking	0.3	0.4	1.4	-0.6	-1.0	-0.4	-0.8	-0.5	-0.4	0.4	-0.6	-0.7	-0.8	-0.1	0.3	1.2	-0.4	-0.9	-0.8	-0.6	-0.7	0.6	-0.1
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	4.4	-1.1	-0.2	-0.4	0.1	-0.5	-0.0	-0.2	0.1	-0.0	-0.3	-0.4	-2.1	0.3	-0.4	-0.3	-0.4	-0.3	-0.4	0.4	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	3.2	-0.7	-0.2	-0.6	-0.6	-0.8	0.0	-1.2	1.8	-0.4	-0.5	-0.6	-1.0	-0.3	-0.5	-0.1	-0.6	-0.8	-0.8	-0.8	-0.4
Ever had bowel cancer screening	0.3	0.3	1.8	0.2	-0.5	0.0	-0.4	-0.5	-0.6	0.0	0.9	-0.7	-0.6	-0.6	-0.0	1.3	-0.6	-0.5	-0.4	0.2	-0.5	-0.4	-0.6
Diabetes diagnosed by doctor	0.3	0.5	3.1	-0.1	-0.7	0.6	-0.1	-0.1	-0.2	0.5	0.4	0.0	-0.3	-0.4	1.7	-0.4	-0.4	1.2	0.5	-0.9	0.3	1.6	-0.7
Qualifications: nursing, teaching	0.3	0.5	4.8	-0.7	0.4	-0.0	-0.7	0.4	-0.5	-0.4	2.2	-0.4	0.0	0.1	0.4	0.9	-0.7	-0.5	-0.1	0.5	-0.5	-0.7	0.2
Medication for cholesterol	0.3	0.4	1.6	0.1	1.1	0.1	0.6	0.9	0.1	-0.3	-1.0	0.5	0.8	1.3	-0.2	0.2	-0.6	0.0	-0.0	0.3	0.4	-1.1	1.0
Breast cancer (self-reported)	0.3	0.4	4.1	0.5	-0.6	-0.3	-0.0	-0.9	0.1	-0.2	-2.0	0.2	-0.3	0.3	-0.7	0.2	-0.1	-0.5	-0.1	0.1	0.1	0.8	0.1
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.9	0.3	-0.0	-0.2	-1.0	-0.7	-0.5	0.9	-1.0	-1.0	-0.4	-0.1	0.3	-1.4	0.4	0.1	-0.5	-0.4	-0.8	0.3	-0.0
Commuting to job workplace: Public transport	0.3	0.4	2.3	-0.1	0.8	-0.4	-0.6	0.8	-0.8	0.2	0.8	-0.8	0.5	-0.2	-0.0	0.3	0.8	0.5	0.5	1.5	-0.0	0.7	0.2
Arm fat-free mass (left)	0.3	1.4	5.7	-1.5	-0.8	0.4	0.8	-0.8	1.1	-0.6	-1.0	1.1	0.0	-0.7	0.4	-2.4	0.6	2.0	0.9	-1.4	0.9	2.4	-0.7
Diastolic blood pressure, automated reading	0.3	0.8	2.9	0.5	-0.3	1.5	-0.0	1.6	-0.0	0.6	-0.1	0.6	0.2	1.1	1.3	-1.7	-1.4	0.7	0.6	-0.5	0.6	0.9	0.6
Myopia	0.3	0.4	1.6	-0.9	-0.3	-1.0	-0.5	0.0	-0.9	-0.7	0.3	-0.8	-0.4	0.6	-1.3	-0.3	0.0	-0.5	-0.4	-0.6	-0.4	-0.5	0.4
Arm predicted mass (left)	0.3	1.4	5.4	-1.6	-0.8	0.1	0.7	-1.0	1.1	-0.9	-1.3	1.0	-0.1	-0.8	0.2	-2.3	0.6	1.8	0.8	-1.4	0.8	2.3	-0.8
Bipolar Disorder (2018)	0.2	0.3	1.8	0.0	-0.8	0.4	0.3	-0.4	0.6	0.7	0.0	0.2	-0.2	-0.7	0.7	-0.1	0.5	0.9	0.3	0.0	0.5	1.4	-0.6
Bipolar Disorder or Schizophrenia	0.2	0.5	1.8	0.5	-1.4	0.7	-0.2	-0.1	-0.3	0.7	1.2	-0.2	-0.6	-1.2	0.5	0.5	-0.6	0.8	0.4	-0.2	0.3	0.9	-1.3
Worry (Nagel 2018)	0.2	0.5	2.0	0.6	-1.1	-0.3	-0.3	0.3	-0.0	0.3	-1.4	-0.2	-0.7	-1.3	0.2	1.1	0.2	-0.3	0.2	0.2	-0.3	-1.1	-1.2
Alzheimer’s Disease (in mother)	0.2	0.3	2.1	0.2	-0.3	0.2	0.3	0.2	0.1	0.2	-0.1	0.1	-0.0	-1.0	-1.5	0.5	0.0	-0.2	0.4	0.5	0.2	-0.9	-0.9
Verbal and Numeric Reasoning (VNR)	0.2	0.5	2.2	-0.3	0.3	-1.3	-0.2	0.2	-1.1	-0.4	1.5	-0.4	0.3	-0.2	-0.5	1.3	-0.3	-0.8	0.6	0.8	0.1	0.1	0.3
Bipolar Disorder (2011)	0.2	0.2	0.9	-0.0	-0.5	0.3	-0.5	0.0	0.3	0.9	-0.7	0.1	-0.4	0.1	0.0	-0.1	-0.0	0.8	-0.4	-0.6	0.0	1.0	0.1
Lupus	0.2	0.3	1.1	0.6	-0.5	1.0	-0.2	0.5	-0.2	1.1	0.4	0.3	-0.3	-0.2	0.6	-0.2	-0.3	0.7	0.6	-1.0	0.0	-0.4	-0.4
Neuroticism (2016)	0.2	0.3	1.6	0.9	0.1	0.9	0.1	1.2	0.1	1.0	-0.4	0.4	0.1	0.7	0.3	-0.8	0.3	1.0	-0.1	-0.0	0.3	0.0	0.3
Systolic Blood Pressure	0.2	1.2	5.2	2.3	0.6	1.4	0.5	0.6	1.0	1.5	-0.6	1.1	0.8	-0.6	1.0	-0.8	0.4	2.1	1.4	0.7	0.9	0.4	-0.5
Neuroticism	0.2	0.6	4.0	0.8	-0.2	-0.4	-0.2	-0.5	0.3	0.7	-2.0	-0.5	-0.2	0.4	1.1	0.1	1.4	0.3	-1.1	0.5	-0.3	-0.9	0.1
Leg fat-free mass (left)	0.2	1.3	6.0	-1.1	-0.4	1.1	0.8	-0.1	1.4	0.1	-1.2	1.4	0.2	0.1	0.4	-2.4	0.6	1.9	0.6	-1.3	0.9	2.1	0.0
Average weekly fortified wine intake	0.2	0.2	1.4	0.9	0.0	0.6	0.0	0.9	0.2	-0.0	0.3	0.4	0.2	0.2	1.2	0.1	-0.1	0.2	0.5	0.2	0.4	-0.8	0.2
Medication: Atenolol	0.2	0.3	0.9	0.9	-0.6	0.6	-0.1	-0.3	0.2	0.9	-0.1	0.2	-0.2	0.4	0.9	0.2	-0.2	0.8	0.1	-0.9	0.3	0.0	-0.1
Financial difficulties in last 2 years	0.2	0.3	1.0	0.6	-0.7	0.6	-0.2	0.1	0.6	0.2	-0.9	0.3	-0.4	-0.2	0.5	-0.3	-0.5	0.6	-0.6	-1.0	-0.0	-0.6	-0.4
Medication: Ramipril	0.2	0.2	0.7	0.8	-0.1	0.6	-0.2	-0.6	-0.3	0.3	0.1	-0.2	0.0	-0.8	-0.3	0.8	-0.1	0.1	-0.2	0.6	0.1	-0.4	-0.8
Trunk fat-free mass	0.2	1.2	4.1	-1.9	-0.9	-0.3	0.3	-1.2	0.7	-0.9	-0.9	0.6	-0.4	-1.2	-0.5	-2.0	0.2	1.6	0.5	-2.0	0.2	1.1	-1.3
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.8	1.4	-0.3	0.7	-0.6	0.1	0.1	0.4	-0.9	-0.1	-0.2	0.0	1.2	-0.0	0.2	1.1	-0.6	0.1	-0.2	0.3	-0.1
Illnesses of mother	0.2	0.3	1.4	0.3	0.3	-0.7	0.2	-0.3	0.3	-0.2	-1.2	-0.0	0.0	-0.1	-1.1	0.7	-0.0	-1.0	-0.1	0.2	-0.2	-0.8	0.1
Trunk predicted mass	0.2	1.2	3.8	-1.8	-1.0	-0.2	0.4	-1.1	0.7	-0.9	-0.8	0.7	-0.4	-1.2	-0.4	-2.0	0.2	1.6	0.5	-1.9	0.3	1.2	-1.3
Standing height	0.2	1.5	9.2	-0.7	0.0	-0.5	1.2	-0.3	1.1	-1.1	3.0	0.9	0.4	-2.6	0.4	0.1	1.1	0.7	1.8	-0.0	0.5	0.4	-1.8
Length of working week for main job	0.2	0.2	1.5	-0.2	-0.3	0.5	0.6	0.6	0.6	0.1	0.5	0.5	-0.1	-0.1	0.4	0.6	0.1	0.3	0.0	-1.2	0.1	-0.7	-0.2
Exposure to tobacco smoke outside home	0.2	0.3	1.2	-0.5	0.8	0.3	0.0	-0.0	-0.1	-0.1	0.1	-0.2	0.5	-0.5	1.1	0.1	0.8	0.9	0.5	0.9	0.3	0.9	-0.4
Medication: Allopurinol	0.2	0.3	2.8	0.2	-0.1	0.3	0.5	0.1	0.3	-0.2	-0.1	0.5	0.2	1.0	1.7	-0.2	-0.1	0.1	0.1	-0.1	0.4	0.1	0.7
Whole body fat-free mass	0.2	1.2	4.8	-1.8	-0.9	0.2	0.5	-0.9	0.9	-0.7	-1.1	0.9	-0.3	-0.8	-0.2	-2.2	0.2	1.7	0.4	-1.8	0.5	1.5	-0.9
Leg fat-free mass (right)	0.2	1.1	4.1	-1.8	-0.8	0.4	0.3	-0.9	1.0	-0.7	-1.4	0.8	-0.4	-0.3	-0.0	-2.0	-0.0	1.5	0.0	-1.9	0.3	1.3	-0.5
Loneliness, isolation	0.2	0.3	1.1	-0.2	-0.6	-0.3	-0.5	-1.1	-0.5	0.3	-0.2	-0.6	-0.6	0.0	0.4	0.7	-0.4	-0.2	-0.6	-1.0	-0.3	-0.7	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	1.3	0.5	0.1	-0.0	0.2	0.7	-0.4	0.8	-0.4	-0.2	0.2	-0.2	-1.1	0.5	0.2	0.0	0.5	0.1	0.3	-0.0	-0.2
Whole body water mass	0.2	1.2	5.2	-1.8	-0.8	0.1	0.5	-1.0	1.0	-0.7	-1.2	0.9	-0.3	-0.7	-0.1	-2.3	0.3	1.7	0.4	-1.8	0.4	1.6	-0.8
Leg predicted mass (right)	0.2	1.0	4.3	-1.7	-0.9	0.5	0.3	-0.8	1.0	-0.7	-1.3	0.8	-0.3	-0.3	0.0	-2.1	-0.1	1.5	0.1	-1.8	0.4	1.4	-0.5
Average weekly champagne plus white wine intake	0.2	0.3	1.5	-0.0	0.2	0.6	0.5	0.1	-0.3	1.2	0.6	0.2	0.6	0.1	-0.4	0.3	0.1	0.6	0.9	0.5	0.8	0.5	0.1
Eye problems/disorders: Glaucoma	0.2	0.3	1.0	-0.8	0.2	-0.7	-0.3	-0.3	-0.3	-0.6	0.8	-0.5	-0.2	0.4	-0.6	-0.3	0.3	-0.8	-1.0	-0.2	-0.5	-0.4	0.4
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.1	0.4	-0.9	-0.1	0.3	-0.6	0.0	-0.2	0.2	0.0	-0.4	-1.0	0.7	1.1	0.7	-0.3	0.2	0.1	0.1	0.8	-0.8
High cholesterol (Self-reported)	0.2	0.4	1.9	0.4	-0.4	0.6	-0.4	-0.4	-0.3	0.5	-0.5	-0.5	-0.2	-1.1	-0.2	-0.8	0.2	1.3	0.9	-0.6	-0.0	-0.1	-1.4
Basal metabolic rate	0.2	1.4	6.6	-1.2	-0.5	0.8	0.8	-0.4	1.2	-0.3	-1.1	1.3	0.1	-0.5	0.5	-2.6	0.6	2.1	0.9	-1.4	0.9	2.0	-0.5
Pain experienced in last month	0.2	0.4	1.6	-1.2	0.3	-1.1	-0.1	-0.8	-0.3	-1.0	0.8	-0.2	-0.1	-0.9	-0.0	-0.0	-0.6	-0.7	0.4	-0.4	-0.6	0.2	-0.3
Height	0.1	2.9	20.3	-0.5	-0.6	-0.3	0.9	-0.3	1.0	-1.3	4.5	1.0	0.1	-3.6	-0.0	-1.1	0.6	1.1	2.4	-0.7	0.5	1.5	-2.6
Hair Pigment	0.1	2.4	5.9	1.8	-0.1	1.8	2.3	1.9	1.9	0.7	2.4	2.3	0.9	1.7	2.4	0.7	0.3	0.5	1.0	0.2	1.9	1.2	1.2
Tanning	0.1	0.9	3.3	-1.8	-0.1	-1.0	-0.1	-1.4	-0.1	-1.5	-0.2	-0.3	-0.3	-0.1	-1.1	-0.9	-0.9	-0.4	-0.9	-1.6	-0.7	-1.4	-0.0
Hand grip strength (left)	0.1	0.3	1.3	-0.7	-0.0	0.1	-0.2	-1.1	1.1	0.2	-0.9	0.7	0.0	-0.6	-0.7	-0.4	0.6	0.9	-0.3	0.0	0.1	-0.4	-0.2
Sensitivity / hurt feelings	0.1	0.2	1.8	0.2	-0.4	-0.2	-0.1	0.0	-0.0	0.2	-0.0	-0.4	-0.2	-0.4	0.5	1.4	0.5	0.3	-0.1	0.0	-0.1	-1.1	-0.7
Hand grip strength (right)	0.1	0.2	1.1	-0.5	0.3	0.6	-0.2	-0.0	0.7	-0.1	0.4	0.5	0.2	-0.7	-0.1	0.1	0.2	1.0	0.2	0.2	0.1	-1.0	-0.3
Maternal smoking around birth	0.1	0.2	0.8	0.1	-0.4	0.3	0.6	-0.1	0.7	0.9	-0.6	0.6	-0.1	0.1	0.2	0.5	0.1	0.4	-0.3	-0.3	0.4	-0.1	-0.0
Fluid intelligence score	0.1	0.2	0.8	-0.4	0.1	-0.7	0.1	0.8	-0.4	-0.2	0.9	0.1	0.2	0.1	-0.4	0.8	-0.2	-0.6	0.5	0.4	0.1	-0.0	0.3
Pulse rate	0.1	0.2	0.6	-0.2	0.2	-0.2	0.2	0.0	0.5	0.7	-0.3	0.4	0.2	0.2	-0.3	0.7	0.7	0.5	0.3	0.5	0.3	0.4	0.1
Happiness	0.1	0.2	0.5	0.7	0.5	0.2	0.2	0.1	-0.0	0.5	0.3	-0.2	0.4	0.3	-0.1	0.3	0.6	0.6	0.7	0.1	0.3	-0.4	0.1
Pulse rate, automated reading	0.1	0.3	2.3	0.8	-0.4	0.2	-0.3	-0.4	0.2	1.5	-0.1	-0.2	-0.2	-0.0	0.4	0.9	0.7	0.6	-0.1	0.4	0.0	0.7	-0.2
Basal cell carcinoma (self-reported)	0.1	0.1	0.7	-0.0	-0.4	0.4	0.2	0.8	0.2	-0.3	0.4	0.3	-0.2	0.3	-0.4	-0.7	-0.4	-0.1	0.1	-0.5	-0.0	0.3	0.1

Hub : Genes

PLA2R1

Models

Trait associations