Hub : Genes

BAZ2B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.0990	0.0390	1.1e-03	0.020	NA	0.007	NA	0.001	1.2e-02	NA	9.4e-02	NA	2.4e-01
2	GTEx	Esophagus Muscularis	0.1220	0.0570	8.3e-03	0.001	NA	0.011	NA	-0.002	2.9e-01	NA	6.3e-02	NA	4.7e-01
3	GTEx	Nerve Tibial	0.1157	0.0539	5.0e-03	0.106	NA	0.111	NA	0.093	5.9e-08	NA	3.2e-08	NA	4.4e-07
4	GTEx	Thyroid	0.0570	0.0280	8.6e-03	-0.002	NA	0.009	NA	-0.004	5.2e-01	NA	5.8e-02	NA	9.5e-01
5	NTR	Blood	0.0453	0.0111	5.0e-12	0.050	0.041	0.046	0.047	0.051	9.1e-16	2.6e-13	1.0e-14	5.6e-15	5.1e-16
6	YFS	Blood	0.2269	0.0304	0.0e+00	0.262	0.313	0.345	0.310	0.344	2.5e-85	2.9e-105	3.0e-118	6.0e-104	6.6e-118

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.3	0.5	1.4	-0.8	0.3	-1.2	-0.5	0.3	0.5
Bipolar Disorder or Schizophrenia	1.1	2.8	6.8	-2.6	0.3	-1.0	-1.8	1.8	1.5
Depressed Affect (Nagel 2018)	0.3	0.6	1.9	0.2	1.4	-0.3	1.1	-0.1	0.8
Depression (Nagel 2018)	0.4	0.6	1.5	-0.4	-0.1	-1.2	-0.3	0.9	1.0
Intelligence (Savage-Jansen 2018)	0.1	0.3	1.0	-0.3	1.0	-0.4	-0.4	-0.1	-0.6
Neuroticism (Nagel 2018)	0.3	0.8	2.7	-0.3	0.7	-0.4	1.6	0.4	1.1
Schizophrenia (2018)	1.4	3.0	7.3	-2.7	0.4	-0.4	-1.9	2.1	1.5
Schizophrenia vs Biploar Disorder	0.2	0.3	1.4	-1.2	-0.1	0.0	-0.5	0.2	-0.3
Worry (Nagel 2018)	0.4	0.8	2.1	-0.9	0.1	-1.4	0.6	0.8	1.0
Alzheimer’s Disease (in mother)	0.2	0.3	0.6	0.8	0.1	-0.8	0.1	0.0	-0.5
Alzheimer’s Disease (in father)	2.1	2.3	6.4	-2.5	0.1	-1.7	-2.0	0.5	-0.3
Alzheimer’s Disease (including proxy)	1.0	1.5	3.2	-1.5	-0.3	-1.1	-1.8	1.5	0.4
Crohns Disease (2017)	1.1	2.4	8.8	-1.3	1.0	-3.0	-1.1	-0.6	-1.2
Irritable Bowel Disease (IBD)	1.3	3.0	8.2	-2.7	0.5	-2.9	-1.5	0.4	-0.1
Ulcerative Colitis (UC)	1.2	2.2	8.6	-2.9	-0.2	-1.2	-1.0	1.0	1.0
Major Depression (MDD)	0.7	0.8	1.8	0.6	0.5	-0.9	-0.3	1.2	1.3
Reaction Time	0.1	0.3	0.9	0.7	0.9	0.5	0.3	-0.2	-0.2
Verbal and Numeric Reasoning (VNR)	0.6	1.5	3.0	-1.7	1.1	-1.5	-1.0	1.3	0.4
Breast Cancer	0.3	0.7	1.6	-0.2	0.5	1.1	-0.5	1.3	0.9
Ovarian Cancer	1.2	1.5	3.3	-1.1	-0.8	-0.8	0.4	1.8	1.8
Prostate Cancer	1.2	1.7	3.6	1.8	-0.1	1.9	0.8	-1.3	-1.1
Age at First Birth	0.3	0.5	1.1	-0.1	0.5	-1.1	-0.7	-0.4	-0.8
Bipolar Disorder (2011)	0.2	0.2	0.5	-0.0	0.1	0.4	0.5	0.1	0.7
Body Mass Index (BMI) (2010)	0.9	1.2	6.9	2.6	-0.4	0.6	-0.0	-0.2	0.2
Coronary Artery Disease (CAD)	1.3	1.6	3.2	-0.6	0.7	1.8	1.1	1.8	1.0
Crohns Disease (2012)	0.7	1.1	2.3	-0.6	1.3	-1.0	0.8	-0.9	-1.5
Mean Putamen Volume	1.5	1.7	3.0	1.7	0.8	0.8	1.3	-1.7	-1.2
Fasting Glucose	0.7	0.9	3.0	0.4	-0.2	1.4	1.7	-0.4	0.1
HbA1C	0.9	1.0	2.5	0.0	1.6	1.4	1.2	0.1	-0.4
HDL Cholesterol	0.5	0.8	2.1	-1.4	0.7	-1.4	0.1	-0.0	-0.4
LDL Cholesterol	0.4	0.6	2.6	0.9	-0.2	-1.6	-0.0	0.1	0.3
Lupus	1.2	1.9	6.0	0.2	0.4	0.8	0.8	2.0	2.4
Neuroticism (2016)	0.8	1.1	3.8	0.7	1.2	-0.1	2.0	0.5	0.9
Primary Biliary Cirrhosis	0.7	1.0	2.9	-1.0	-1.7	-0.6	-0.0	-0.6	-1.1
Rheumatoid Arthritis	1.2	1.7	4.8	0.5	0.1	0.3	0.5	-2.2	-2.1
Schizophrenia (2014)	1.9	4.1	10.6	-3.2	-0.4	-0.8	-1.7	2.5	2.1
Triglycerides	0.5	0.8	1.7	0.4	0.5	0.9	1.2	0.9	1.3
Type 2 Diabetes (T2D) (2012)	1.5	1.7	5.0	-0.2	-0.0	2.2	0.3	1.6	1.5
Ulcerative Colitis	0.9	1.3	3.8	-1.9	0.1	-0.3	-0.7	1.0	1.4
Blood Eosinophil Count	0.3	2.4	9.9	3.1	0.9	0.2	-1.3	-1.0	1.0
Blood Platelet Count	1.0	12.1	38.6	-2.8	0.8	-2.8	-6.2	1.7	3.9
Blood Red Count	0.3	2.8	7.1	-1.7	-2.3	-1.1	-0.6	0.4	2.7
Blood White Count	7.7	56.9	166.4	-3.0	5.7	3.1	-3.1	10.7	12.9
Heel T-Score	0.5	4.1	6.5	0.6	-1.8	2.5	1.9	-2.5	-2.3
BMI	0.5	2.7	9.1	3.0	0.9	0.7	-1.7	-1.6	-0.7
Height	0.1	1.5	5.4	0.2	-2.3	-0.5	-1.3	-1.0	-0.9
Waist Hip Ratio (WHR)	1.2	5.5	11.1	-3.0	-0.7	1.4	0.1	3.2	3.3
Systolic Blood Pressure	0.2	0.8	2.6	-0.3	0.8	0.0	1.6	0.4	1.1
Smoking Status	0.9	2.2	9.9	0.3	3.2	0.8	1.1	-1.1	-0.2
Allergy or Eczema	0.5	1.2	2.7	-1.4	0.2	-0.3	-0.4	1.6	1.6
Cardiovascular Disease	0.5	1.5	3.6	1.2	-1.9	0.3	-0.3	0.7	1.9
Hypothyroidism (self reported)	4.1	9.4	26.3	-2.0	1.0	-0.3	-1.8	5.1	4.6
Respiratory disease	1.0	2.3	6.7	0.1	-2.6	1.3	0.2	0.9	2.2
Type 2 Diabetes (T2D) (2018)	1.8	3.3	7.7	-0.9	1.9	0.8	-0.1	2.8	2.7
Lung FEV1/FVC ratio	2.0	10.3	23.5	3.4	-0.7	-0.4	2.8	-4.3	-4.8
Lung FVC	2.0	10.1	24.0	-3.2	-1.8	-4.9	-4.5	1.6	0.3
Neuroticism	0.2	0.5	1.2	0.1	1.1	-0.5	1.0	0.3	0.5
Chronotype (morning person)	0.8	1.8	4.9	-1.2	-1.1	2.2	0.5	1.3	1.3
Hair Pigment	0.1	2.7	5.7	-1.2	0.2	1.7	1.2	2.4	2.1
Tanning	0.1	1.3	4.0	2.0	0.8	0.3	-0.9	-0.8	-1.2
Hand grip strength (left)	0.5	1.3	3.4	1.2	-1.0	-0.3	0.4	-1.9	-1.2
Number of treatments/medications taken	1.2	2.1	2.7	-1.4	-1.6	0.9	-1.6	1.4	1.6
Average weekly spirits intake	1.4	1.7	7.3	2.7	-0.5	1.2	0.5	0.0	1.0
Sensitivity / hurt feelings	0.3	0.4	0.8	-0.9	-0.2	0.1	0.4	0.9	0.9
Frequency of depressed mood in last 2 weeks	0.6	0.8	2.7	-0.6	0.4	-0.7	0.1	1.0	1.6
Hearing difficulty/problems: Yes	1.6	2.4	3.8	-1.1	1.9	-1.5	-1.5	2.0	1.2
Relative age of first facial hair	0.3	0.6	2.6	-0.6	1.6	-0.1	0.7	0.5	-0.0
Other serious medical condition/disability diagnosed by doctor	1.7	2.2	6.8	-0.3	0.3	0.6	-0.7	2.3	2.6
Ever used hormone-replacement therapy (HRT)	0.5	0.7	3.8	0.3	0.2	1.9	-0.0	0.4	-0.0
Ever had hysterectomy (womb removed)	0.7	0.7	2.8	0.7	-0.4	1.7	0.1	0.1	1.0
Systolic blood pressure, automated reading	0.4	1.2	3.0	0.7	1.7	1.0	1.6	-0.6	-0.1
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	1.6	-1.3	1.3	0.9	0.1	1.1	1.2
Angina	0.3	0.3	0.7	0.8	0.8	0.6	0.5	-0.3	0.3
Medication for hormone replacement therapy	1.1	1.2	5.4	-0.8	0.1	-0.7	-2.3	0.7	-0.5
Vitamin and mineral supplements	0.6	0.8	1.2	1.1	-1.0	-0.4	-1.0	0.9	1.0
Supplements: Zinc	1.0	1.1	3.1	1.0	0.6	0.8	1.8	-0.5	-1.0
Medication: Co-codamol	0.6	0.7	1.5	1.0	-1.2	0.3	-0.5	-1.1	-0.5
Medication: Metformin	1.7	2.3	5.6	0.2	2.4	1.2	0.8	1.6	2.0
Diabetes (father)	1.1	1.4	4.1	1.8	0.9	-0.5	2.0	-0.4	0.1
Diabetes (mother)	0.3	0.4	1.0	0.1	-0.7	-1.0	0.4	0.3	0.6
Severe depression (siblings)	2.1	2.4	6.8	-0.8	1.0	-0.3	-1.5	2.6	1.9
Pack years adult smoking proportion	1.5	2.3	6.0	0.7	1.2	2.1	2.4	-0.4	1.1
Impedance of leg (right)	0.3	1.3	5.3	-2.3	-0.3	-0.1	0.5	1.3	0.7
Leg fat-free mass (left)	0.5	2.6	10.1	3.2	0.2	0.8	-1.0	-1.8	-0.6
Trunk fat percentage	0.6	2.4	6.7	2.2	0.6	2.6	-0.3	-1.4	-0.6
Hand grip strength (right)	0.4	1.2	2.7	1.1	-0.8	-1.1	0.9	-1.6	-0.9
Townsend deprivation index at recruitment	1.4	1.9	7.8	0.0	-0.0	1.4	0.6	1.2	2.8
Current tobacco smoking	0.6	1.0	2.9	0.3	1.7	1.1	1.0	-0.2	0.9
Average weekly fortified wine intake	0.5	0.6	2.0	0.8	-1.4	0.0	-0.8	0.2	0.4
Maternal smoking around birth	0.5	0.7	1.2	-1.1	0.9	1.0	0.2	0.7	0.7
Fed-up feelings	0.9	1.6	4.0	0.1	2.0	1.2	1.0	0.5	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.8	0.0	-0.4	-0.8	-0.9	0.5	0.4
Relative age voice broke	1.0	1.5	3.7	-0.7	1.7	1.2	1.9	0.7	-0.3
Taking other prescription medications	2.2	3.4	11.2	-0.4	-1.8	0.3	-1.4	1.9	3.3
Age when periods started (menarche)	0.4	0.9	3.6	-1.9	0.4	-0.0	0.5	1.1	0.3
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	5.8	0.7	-2.4	0.5	0.5	-0.7	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	2.0	-0.8	-1.4	0.4	0.0	-0.7	-1.2
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.3	0.0	-0.4	1.1	1.0	-0.1	-0.1
Qualifications: CSEs or equivalent	0.9	1.1	4.3	0.4	0.7	2.1	0.2	0.8	1.1
Serious illness, injury or assault to yourself	0.6	0.7	1.7	0.5	-0.2	0.4	-1.0	0.9	1.3
High blood pressure	0.2	0.5	1.7	0.6	-0.1	1.3	0.4	0.3	1.0
Hayfever, allergic rhinitis or eczema	0.7	1.4	3.3	-1.6	-0.1	-0.3	-0.6	1.8	1.5
Multivitamins +/- minerals	0.6	0.7	1.8	-1.3	1.3	0.3	0.2	-0.5	-0.7
Stomach or abdominal pain in last month	1.0	1.3	3.0	-1.7	-0.9	-0.5	-0.5	1.2	1.4
Supplements: Glucosamine	0.8	1.0	2.5	-0.1	1.2	1.3	0.5	-0.6	-1.6
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	3.5	0.5	1.9	0.8	0.8	0.6	0.5
Medication: Atenolol	1.2	1.5	3.4	-1.7	-0.6	0.1	-0.3	1.8	1.6
Medication: Levothyroxine sodium	4.4	7.4	19.6	-2.3	0.2	-1.0	-1.5	4.4	4.1
Sitting height	0.3	2.2	10.4	0.0	-3.2	-0.5	-1.1	-0.8	-0.7
Chronic bronchitis/emphysema (father)	2.7	3.1	6.5	-2.1	-0.9	0.1	-1.3	2.5	2.3
High blood pressure (mother)	0.2	0.3	0.9	0.9	-0.1	-0.4	0.6	-0.2	0.6
Body mass index (BMI)	0.7	3.2	11.8	3.4	0.9	1.8	-0.7	-1.6	-0.6
Impedance of leg (left)	0.3	1.6	8.4	-2.9	-0.4	-0.1	0.2	1.1	0.1
Leg predicted mass (left)	0.5	2.6	10.5	3.2	0.2	0.9	-0.9	-1.8	-0.6
Trunk fat mass	0.6	2.7	6.6	2.6	0.4	2.5	-0.4	-1.6	-0.7
Waist circumference	0.4	1.6	5.0	1.6	0.5	2.2	-1.0	0.3	1.0
Number of incorrect matches in round	0.3	0.5	1.0	0.7	-0.2	-0.6	0.8	-0.8	-1.0
Past tobacco smoking	0.9	1.6	5.8	0.9	-2.4	0.1	1.4	-0.9	-0.4
Alcohol usually taken with meals	0.9	1.5	4.0	-0.2	1.1	-2.0	-1.8	0.6	0.6
Nervous feelings	0.3	0.6	3.1	0.0	0.2	-0.3	1.8	-0.1	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	2.4	1.1	-1.2	-1.5	0.6	-0.6	-0.1
Hearing difficulty/problems with background noise	1.7	2.7	6.4	-1.6	1.3	-0.1	-1.6	2.5	1.7
Hair/balding pattern: Pattern 2	1.2	1.5	5.9	0.8	1.2	2.4	0.4	-0.6	-0.5
Had menopause	3.4	4.2	10.6	2.0	0.7	0.1	1.7	-2.7	-3.2
Had other major operations	1.4	1.8	4.7	-1.5	1.2	0.2	-0.6	1.3	2.2
Forced vital capacity (FVC)	1.9	7.3	16.8	-2.7	-1.9	-3.6	-4.1	1.8	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.3	-1.2	-1.1	-0.2	-0.3	-0.6	-1.5
Ever unenthusiastic/disinterested for a whole week	1.4	1.7	3.7	0.0	1.9	1.0	0.2	1.4	1.9
Qualifications: None of the above	0.4	0.9	2.3	1.5	0.6	1.5	0.6	-0.0	0.4
Financial difficulties in last 2 years	0.1	0.2	0.6	0.0	0.2	-0.2	-0.1	0.6	0.8
Mouth/teeth dental problems	1.5	2.3	6.4	2.5	0.1	0.0	0.4	-2.0	-1.8
Heart attack	0.5	0.7	3.1	-0.3	-1.8	0.6	-0.5	-0.5	0.1
Allergy	0.6	1.4	3.6	0.6	1.1	-0.3	0.6	-1.7	-1.9
Pain all over the body in last month	0.4	0.5	1.3	-0.4	-0.4	-1.2	0.1	0.8	0.6
Diabetes (self-reported)	0.4	0.7	1.8	-0.1	0.7	0.5	0.5	1.3	1.2
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	3.8	0.5	-1.9	-0.4	0.8	0.1	-0.0
Medication: Ramipril	0.3	0.3	0.9	-0.4	-0.8	-1.0	-0.1	-0.4	0.2
Medication: Simvastatin	0.5	0.8	2.8	1.0	-1.7	-0.6	0.6	0.2	0.2
Fluid intelligence score	0.0	0.0	0.1	0.1	0.3	-0.2	0.1	0.2	0.0
Illnesses of siblings	0.2	0.3	1.1	1.0	-0.5	-0.5	-0.1	-0.4	-0.4
Neuroticism score	0.4	0.8	2.7	-0.3	1.6	-0.2	0.9	0.7	1.0
Weight	0.5	2.6	9.2	3.0	0.4	1.7	-1.0	-1.5	-0.6
Impedance of arm (right)	0.2	1.1	3.3	-1.8	-0.9	-0.1	0.1	1.2	1.1
Arm fat percentage (right)	0.6	2.3	7.7	2.8	0.3	2.0	-0.6	-1.3	-0.3
Trunk fat-free mass	0.4	2.5	8.9	3.0	-0.3	0.5	-1.0	-1.9	-1.2
Hip circumference	0.7	3.0	13.0	3.6	0.8	1.2	-1.2	-1.1	-0.6
Time employed in main current job	0.8	0.9	4.0	-0.9	-2.0	-0.7	-0.1	0.3	0.0
Alcohol intake versus 10 years previously	2.9	4.4	7.8	-2.5	-0.2	-1.1	-2.4	2.8	2.3
Father’s age at death	0.1	0.2	0.6	0.1	0.8	0.1	0.5	0.2	0.2
Worrier / anxious feelings	0.2	0.3	1.1	0.1	0.2	-0.9	1.0	0.0	-0.3
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.2	4.6	-2.0	1.3	-0.7	-0.1	1.6	2.1
Falls in the last year	1.6	2.2	4.7	-2.2	0.5	-0.2	-1.6	1.7	1.6
Hair/balding pattern: Pattern 3	0.6	0.8	2.5	1.5	-0.4	0.1	1.6	-0.3	-0.1
Number of live births	0.3	0.4	1.0	0.3	0.8	1.0	-0.2	0.3	0.6
Forced expiratory volume in 1-second (FEV1)	1.3	4.5	11.4	-1.7	-1.7	-3.4	-2.9	0.8	-0.5
Pulse rate	0.6	1.0	2.2	-1.5	1.5	0.2	1.1	0.2	0.7
Happiness	1.0	1.2	2.8	-1.2	0.9	-0.1	-0.7	1.7	1.2
Noisy workplace	0.3	0.4	1.1	1.1	0.5	0.4	0.7	-0.5	0.2
Qualifications: A levels/AS levels or equivalent	1.1	2.4	9.3	-0.8	-1.0	-3.0	-1.9	0.2	0.2
Serious illness, injury or assault of a close relative in last 2 years	3.5	4.0	7.7	-2.5	0.7	-1.3	-2.2	2.8	1.8
Mouth/teeth dental problems: Dentures	1.5	2.5	4.8	-2.2	-0.1	-0.8	-1.7	2.0	1.7
Asthma	1.3	2.5	7.8	1.0	-2.8	1.3	-0.5	0.7	1.9
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	3.7	-0.9	1.9	1.5	-0.2	1.7	1.6
Medication: Cholesterol lowering	0.7	1.1	2.8	0.4	-0.5	1.7	1.0	1.0	1.3
Depression (self-reported)	0.9	1.1	2.9	-1.0	0.2	-1.4	-1.7	0.7	0.5
Medication: Lansoprazole	0.8	0.9	2.7	-0.5	-1.6	-0.6	-1.4	-0.2	0.0
Prospective memory result	1.5	1.8	2.9	-1.1	-1.7	1.4	1.2	-1.5	-1.1
Lung cancer (father)	0.3	0.4	1.1	-0.3	0.4	1.0	0.6	-0.1	0.7
Illnesses of mother	0.6	0.7	3.6	-1.9	0.1	0.1	-0.7	0.6	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	2.0	6.4	15.7	-1.9	-2.5	-4.0	-3.4	0.5	-0.9
Pulse wave Arterial Stiffness index	0.4	0.4	1.1	-0.2	-1.0	0.6	1.0	-0.5	0.1
Impedance of arm (left)	0.3	1.6	4.9	-2.2	-0.3	-0.5	0.5	1.4	1.4
Arm fat mass (right)	0.7	2.8	9.4	3.1	0.1	1.9	-0.9	-1.5	-0.5
Trunk predicted mass	0.4	2.3	8.3	2.9	-0.4	0.4	-1.0	-1.7	-1.1
Standing height	0.0	0.3	1.3	-0.2	-1.1	-0.1	-0.7	0.0	0.0
Length of working week for main job	0.4	0.5	1.2	0.7	-1.1	0.1	-0.1	-1.0	-0.4
Exposure to tobacco smoke at home	0.7	0.8	2.1	0.5	1.4	0.5	1.1	0.2	1.0
Breastfed as a baby	0.9	1.2	2.8	-0.5	1.1	-0.7	-0.6	1.7	1.3
Tense / ‘highly strung’	0.8	1.3	2.5	-1.6	0.5	-1.2	-0.7	1.4	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.9	2.9	7.1	1.4	2.0	1.7	0.4	1.1	2.7
Hair/balding pattern: Pattern 4	0.4	1.0	3.2	-0.4	1.8	-1.0	0.1	0.7	1.1
Birth weight of first child	3.3	5.9	11.7	2.0	-2.0	-2.1	-0.7	-3.3	-3.4
Peak expiratory flow (PEF)	0.6	1.3	3.6	-1.1	-0.0	-1.9	-1.6	0.8	0.3
Pulse wave reflection index	0.8	1.0	4.7	0.5	-2.2	-0.3	0.5	-0.2	-0.6
Ever highly irritable/argumentative for 2 days	1.5	1.8	6.2	-0.2	1.7	-0.2	-0.2	1.3	2.5
Loud music exposure frequency	0.5	0.6	2.0	-0.6	1.4	0.2	0.2	0.6	0.7
Qualifications: O levels/GCSEs or equivalent	1.3	2.0	6.4	-1.7	0.8	-2.5	-1.4	-0.1	-0.4
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	2.0	-1.4	-0.5	0.4	0.6	0.0	-0.3
Blood clot in the leg (DVT)	1.1	1.5	2.7	0.2	-1.6	1.3	0.9	-1.6	-1.1
Medication: Paracetamol	0.5	0.8	3.8	-0.0	-0.1	-0.8	-2.0	0.5	0.3
Headache pain in last month	0.3	0.6	1.0	-0.4	0.9	-0.1	-1.0	0.9	0.8
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	2.6	0.1	0.9	-1.1	-0.3	-1.0	-1.6
Glaucoma (self-reported)	0.7	0.8	2.1	0.7	1.5	0.3	-0.3	-1.0	-0.9
Gout (self-reported)	0.5	0.7	1.9	0.5	0.0	1.4	0.6	0.9	0.8
Hypothyroidism/myxoedema (self-reported)	3.1	6.0	17.5	-1.6	0.3	-0.7	-1.5	4.2	3.6
Medication: Amlodipine	0.3	0.4	2.1	-0.2	0.1	-0.0	-1.4	0.3	0.2
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.7	-1.0	-1.0	-0.8	-0.2	0.9	1.3
Birth weight	3.5	7.6	19.7	1.9	-2.0	-0.3	0.3	-4.3	-4.4
Chronic bronchitis/emphysema (mother)	2.1	2.4	5.9	-1.2	1.5	0.1	1.1	1.9	2.4
High blood pressure (siblings)	0.7	1.0	2.5	-0.5	1.1	0.2	1.1	1.0	1.6
Forced vital capacity (FVC), Best measure	2.3	8.5	19.9	-2.3	-2.5	-4.2	-4.5	1.1	-0.1
Body fat percentage	0.6	2.4	6.2	2.3	0.9	2.5	-0.4	-1.2	-0.5
Leg fat percentage (right)	0.5	1.8	4.3	2.1	1.4	1.9	-0.8	-0.8	-0.2
Arm fat-free mass (right)	0.6	3.2	11.1	3.3	0.2	1.2	-0.5	-2.1	-1.5
Exposure to tobacco smoke outside home	0.8	1.1	3.4	-0.9	1.8	0.9	-0.3	0.9	0.8
Comparative body size at age 10	2.6	7.1	19.0	2.6	-0.3	-0.7	-0.3	-4.1	-4.4
Number of full brothers	1.3	1.6	3.1	-1.5	-0.5	-0.1	-1.1	1.6	1.8
Worry too long after embarrassment	0.8	1.4	4.5	1.0	2.1	-0.4	1.6	-0.3	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	2.8	-1.5	-0.2	-0.2	-0.2	1.2	1.7
Wheeze or whistling in the chest in last year	1.4	2.6	8.8	1.1	-0.2	1.8	0.6	1.4	3.0
Number of children fathered	0.1	0.1	0.3	0.3	0.3	0.5	0.4	0.3	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.2	-1.0	0.2	0.2	-0.5	0.1	-1.1
Age at first live birth	1.4	2.4	6.8	0.1	1.1	-2.6	0.5	-1.8	-1.8
Pulse wave peak to peak time	0.4	0.5	1.4	0.2	0.9	-0.7	-1.2	0.5	-0.1
Health satisfaction	0.4	0.5	1.0	-0.5	0.8	-0.4	-1.0	0.6	0.8
Shortness of breath walking on level ground	0.2	0.3	1.0	0.1	-0.4	1.0	-0.6	0.2	0.2
Qualifications: College or University degree	0.2	0.5	1.7	-0.2	0.0	-1.3	-0.8	0.6	0.5
Eye problems/disorders: None of the above	0.7	0.8	2.8	1.7	-0.4	0.9	0.9	-0.4	0.2
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.9	0.8	-0.2	0.4	1.1	-1.4	-0.9
Emphysema/chronic bronchitis	1.2	1.4	3.9	0.3	1.0	2.0	0.5	1.1	1.4
Medication for pain relief, constipation, heartburn	0.7	1.2	2.0	1.1	-0.2	-0.8	1.3	-1.4	-1.2
Neck or shoulder pain in last month	1.4	1.9	5.3	-1.5	0.6	-0.9	-2.3	1.2	1.2
Medication: Blood pressure	0.4	0.6	1.7	-0.2	-0.7	0.5	-0.7	1.0	1.3
Angina (self-reported)	0.2	0.3	0.7	0.8	0.6	0.4	0.1	-0.3	0.3
Migraine (self-reported)	0.6	0.7	1.8	-0.9	-1.3	-0.4	-1.0	0.8	0.4
Medication: Ibuprofen	2.2	2.6	4.9	-0.7	2.0	2.2	0.6	1.8	1.8
Medication: Allopurinol	1.1	1.5	5.1	1.1	0.3	2.2	1.5	0.3	0.5
Medication: Omeprazole	0.7	0.8	3.9	-0.4	-0.2	2.0	0.0	0.3	0.9
Medication: Seretide 50 evohaler	0.6	0.6	1.3	0.0	-1.1	-0.1	0.2	-1.1	-1.1
Mean time to correctly identify matches	0.5	1.0	3.3	0.6	1.8	0.4	0.3	-0.7	-1.2
Heart disease (mother)	0.5	0.7	1.2	1.1	-0.9	1.1	-0.2	-0.4	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.0	-0.5	1.1	1.4	1.2	-0.3	-0.4
Whole body fat mass	0.6	2.5	7.1	2.7	0.6	2.2	-0.6	-1.4	-0.5
Leg fat mass (right)	0.6	2.5	7.3	2.7	1.2	2.1	-0.8	-1.1	-0.4
Arm predicted mass (right)	0.5	2.4	8.2	2.9	0.2	1.1	-0.5	-1.8	-1.2
Pulse rate, automated reading	1.2	3.9	14.1	-3.8	1.0	0.0	0.2	1.6	2.4
Alcohol intake frequency.	2.2	5.2	10.2	-2.1	-1.9	-0.9	-1.8	3.2	3.0
Comparative height size at age 10	0.5	2.8	6.4	2.0	-0.8	-0.3	-1.1	-2.5	-2.1
Number of full sisters	3.1	3.8	13.9	-0.7	0.3	0.8	0.5	2.7	3.7
Suffer from ‘nerves’	0.9	1.4	3.4	-0.6	1.9	-1.3	-0.2	1.2	1.3
Overall health rating	0.9	1.9	4.4	-1.9	-0.9	0.1	-0.9	1.3	2.1
Chest pain or discomfort	0.7	1.1	4.4	0.1	0.2	0.3	-0.8	1.1	2.1
Had major operations	1.7	2.0	4.0	-2.0	0.8	0.9	-0.5	1.9	1.6
Age at last live birth	0.6	0.9	4.1	0.4	2.0	-1.1	0.2	-0.2	-0.3
Family relationship satisfaction	4.1	5.0	10.0	-2.7	0.8	2.0	0.0	3.2	2.9
Leg pain on walking	1.9	2.3	5.3	-1.2	-0.1	-0.8	-1.6	2.3	2.0
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.9	0.3	-0.9	0.7	-0.1	-0.7	-1.0
Commuting to job workplace: Car/motor vehicle	0.9	1.0	2.4	-0.4	-0.6	1.5	1.4	0.2	1.0
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.8	0.4	0.2	-0.1	1.0	-1.3	-1.0
Medication: Aspirin	0.2	0.3	0.5	0.7	-0.7	0.5	-0.0	-0.5	-0.4
Supplements: Vitamin C	1.0	1.1	3.3	0.5	0.3	0.5	1.8	-1.1	-1.3
Knee pain experienced in last month	0.6	0.9	2.8	0.5	1.7	0.7	0.4	0.6	1.1
Hypertension (Self-reported)	0.2	0.6	1.5	0.8	-0.7	0.8	0.1	0.5	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.7	0.2	-1.2	0.5	-0.1	-1.3	-0.8
Illnesses of father: Heart disease	0.8	1.1	2.8	1.7	1.4	0.6	1.0	0.2	0.8
Illnesses of siblings: Diabetes	0.5	0.6	3.1	-0.6	0.5	1.8	0.2	-0.2	-0.2
Smoking status: Previous	0.7	1.1	3.3	-0.7	1.8	-0.4	-1.5	0.6	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	1.1	0.3	-1.0	-0.3	0.4	-0.3	-0.2
Whole body fat-free mass	0.5	2.8	9.5	3.1	-0.2	0.9	-0.9	-2.0	-1.2
Leg fat-free mass (right)	0.5	2.5	8.7	3.0	-0.1	0.7	-1.0	-1.9	-0.9
Arm fat percentage (left)	0.5	2.0	6.4	2.5	0.8	1.8	-0.3	-1.2	-0.2
Average weekly red wine intake	0.9	1.3	1.9	0.9	1.3	1.3	0.2	-1.4	-1.3
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.4	-0.8	-0.6	0.3	-1.2	-0.6	-0.9
Mood swings	0.6	1.1	5.1	0.7	2.3	0.3	0.7	-0.1	0.4
Loneliness, isolation	1.8	2.5	5.4	-1.4	1.0	-1.7	-0.0	1.9	2.3
Long-standing illness, disability or infirmity	2.5	3.8	11.6	-1.5	0.6	0.2	-0.4	2.9	3.4
Ever had bowel cancer screening	2.2	2.6	6.1	-2.5	0.9	0.1	-0.9	2.1	1.9
Diabetes diagnosed by doctor	1.2	2.0	4.4	-0.6	1.6	0.9	0.6	2.1	1.9
Ever had stillbirth, spontaneous miscarriage or termination	3.6	3.9	7.8	-1.7	1.8	-0.5	-2.2	2.8	2.1
Friendships satisfaction	1.7	2.1	4.3	-1.2	1.6	0.9	-0.2	2.1	1.8
Qualifications: nursing, teaching	0.2	0.3	0.5	-0.2	-0.0	-0.6	0.5	0.6	0.7
Commuting to job workplace: Walk	1.0	1.1	4.9	0.6	1.0	-2.2	-0.2	0.1	0.3
Eye problems/disorders: Cataract	0.9	1.0	2.2	-0.1	-0.8	-1.5	-1.1	-0.5	-1.4
Mouth/teeth dental problems: Mouth ulcers	0.3	0.6	2.1	-1.0	-1.4	-0.2	0.4	-0.0	-0.3
Medication for cholesterol	0.5	0.7	3.2	0.1	0.4	0.9	1.8	0.0	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	3.4	-0.5	-1.8	-1.8	-1.3	-0.2	-0.1
Back pain experienced in last month	0.2	0.3	1.3	-0.3	-1.1	0.2	-0.6	-0.2	0.2
Mineral and other dietary supplements	0.4	0.5	1.5	0.4	-0.4	-1.0	-1.2	0.1	0.6
Breast cancer (self-reported)	0.2	0.2	0.8	-0.3	0.0	-0.7	-0.9	-0.3	0.0
Asthma (self-reported)	1.4	2.7	10.1	1.1	-3.2	1.2	-0.5	0.5	1.7
Osteoporosis (self-reported)	0.4	0.5	1.2	-0.9	-0.4	-1.1	-0.9	0.1	0.1
Osteoarthritis (self-reported)	0.6	0.8	2.7	0.6	1.7	0.3	-0.1	0.5	1.3
Medication: Aspirin	0.2	0.2	0.5	0.6	-0.7	-0.0	-0.6	-0.3	-0.2
Medication: Gliclazide	0.5	0.5	1.5	0.3	1.2	1.0	0.7	0.1	0.2
Illnesses of father: None of the above (group 1)	2.2	2.7	4.4	-0.9	-2.1	-1.2	-1.9	-1.5	-1.9
Smoking status: Current	0.9	1.4	3.8	0.6	2.0	1.3	1.3	-0.5	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.2	4.6	12.9	-1.5	-2.3	-3.6	-2.5	1.0	-0.3
Whole body water mass	0.5	2.9	10.3	3.2	-0.1	1.0	-0.8	-2.0	-1.1
Leg predicted mass (right)	0.4	2.3	8.5	2.9	-0.1	0.7	-1.0	-1.8	-0.8
Arm fat mass (left)	0.7	2.7	9.3	3.0	0.4	1.9	-0.7	-1.5	-0.5
Number of self-reported non-cancer illnesses	1.5	2.6	6.7	-1.1	-1.8	1.5	-0.4	1.6	2.6
Average weekly champagne plus white wine intake	0.2	0.3	0.7	0.6	-0.5	0.3	0.3	-0.8	0.0
Miserableness	1.5	2.5	6.6	1.9	2.6	0.9	1.3	0.5	1.4
Guilty feelings	0.9	1.4	3.1	-0.0	0.9	1.2	-0.1	1.7	1.8
Wears glasses or contact lenses	0.2	0.3	1.4	0.3	-1.2	-0.0	-0.0	-0.3	-0.3
Ever taken oral contraceptive pill	3.1	3.5	8.8	-1.8	1.4	-0.4	-0.7	3.0	2.5
Hearing aid user	0.6	0.7	2.1	0.5	1.4	-1.1	-0.4	-0.7	-0.2
Mother’s age at death	2.1	2.7	5.3	1.2	-1.5	0.7	1.5	-2.1	-2.3
Financial situation satisfaction	0.9	1.1	3.5	-1.9	-0.1	-0.2	-1.5	0.9	0.3
Tinnitus: Yes, now most or all of the time	1.4	1.6	3.6	0.4	1.4	1.3	-0.3	1.5	1.9
Commuting to job workplace: Public transport	0.9	1.0	2.1	-0.7	1.2	-1.3	-1.5	0.6	-0.2
Eye problems/disorders: Glaucoma	1.3	1.6	4.0	0.9	0.9	0.6	0.1	-2.0	-1.8
Medication: Blood pressure	0.8	1.6	3.6	0.4	-1.7	-0.5	-0.5	-1.9	-1.5
Pain type(s) experienced in last month: Hip pain	1.1	1.4	5.6	-0.7	-0.2	-0.6	-2.4	1.2	0.8
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.2	-0.6	0.3	1.1	1.1	-0.3	-0.6
High cholesterol (Self-reported)	0.4	0.8	3.7	0.8	-1.9	0.3	-0.0	-0.5	0.2
Medication: Bendroflumethiazide	0.4	0.5	1.8	0.2	0.1	-0.6	0.6	-1.3	-0.8
Medication: Paracetamol	0.6	0.9	3.6	-0.7	-0.5	-0.8	-1.9	0.4	0.3
Medication: Lisinopril	0.7	0.9	3.2	0.4	-1.2	-0.5	-1.8	-0.5	-0.3
Medication: Atorvastatin	1.5	1.9	5.3	-0.7	-0.7	1.7	0.4	1.4	2.3
Illnesses of father: High blood pressure	0.5	0.7	3.2	-0.2	0.3	0.5	1.8	0.5	0.2
Alcohol drinker status: Never	3.4	4.1	7.3	-2.1	-1.3	-2.0	-2.7	1.7	2.1
Ever smoked	1.0	1.7	7.5	-1.0	2.7	0.6	-0.8	0.7	0.4
Basal metabolic rate	0.5	2.8	10.4	3.2	-0.1	1.0	-1.1	-1.9	-1.0
Leg fat percentage (left)	0.5	1.8	3.6	1.9	1.2	1.9	-0.9	-1.0	-0.7
Arm fat-free mass (left)	0.6	3.0	10.3	3.2	-0.1	1.3	-1.0	-1.8	-1.3
Number of operations (self-reported)	1.2	1.8	4.8	-0.6	0.6	2.2	1.3	0.5	1.8
Average weekly beer plus cider intake	0.7	1.0	2.1	-0.8	0.0	1.5	-0.6	1.0	1.2
Irritability	0.5	0.8	2.1	-1.4	-0.3	1.1	0.9	0.8	0.4
Risk taking	2.2	3.2	7.9	0.1	0.9	2.1	-1.3	2.0	2.8
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.1	1.0	0.8	0.8	-0.6	-0.5	-0.6
Fractured/broken bones in last 5 years	1.3	1.7	3.9	-1.8	0.2	1.1	0.2	1.2	2.0
Age started oral contraceptive pill	1.0	1.3	5.4	-0.7	-0.9	-2.3	0.6	0.7	0.5
Diastolic blood pressure, automated reading	0.3	0.8	2.1	1.5	-1.1	0.2	1.0	-0.9	0.1
Ever depressed for a whole week	0.9	1.1	2.5	1.2	0.9	1.6	1.2	0.2	0.5
Unable to work because of sickness or disability	1.8	2.3	4.8	-2.2	-1.4	-1.0	-0.3	1.4	2.1
Commuting to job workplace: Cycle	1.2	1.5	5.6	0.2	0.9	-1.0	-2.4	1.2	0.3
Myopia	0.6	0.9	2.6	-0.1	1.6	-0.0	-0.1	-1.0	-1.5
Vascular/heart problems diagnosed by doctor	0.2	0.7	2.2	-0.5	0.2	-1.1	0.0	-0.6	-1.5
Cholesterol lowering medication	0.3	0.5	1.2	1.0	-1.1	-0.2	-0.4	-0.5	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.0	-0.3	-0.5	1.0	-0.5	0.1	0.9
Pain experienced in last month	0.2	0.4	0.8	0.9	0.4	-0.4	0.9	-0.3	-0.6
Supplements: Calcium	0.6	0.7	1.6	-0.7	1.3	0.5	1.2	0.3	0.1
Basal cell carcinoma (self-reported)	0.1	0.2	0.3	-0.1	0.2	0.3	-0.6	-0.6	-0.3
Heart attack/myocardial infarction (self-reported)	0.5	0.7	3.0	-0.4	-1.7	0.7	-0.5	-0.5	-0.0
Deep venous thrombosis (DVT) (self-reported)	1.4	1.7	3.6	0.6	-1.7	1.2	0.9	-1.9	-1.2
Heart disease (siblings)	0.4	0.4	1.6	-0.4	-0.5	1.3	-0.0	-0.3	-0.7
Alcohol drinker status: Previous	4.2	4.8	10.3	-2.1	-1.1	0.7	-1.6	3.2	3.1
Pack years of smoking	1.4	2.0	5.6	0.5	1.1	1.9	2.4	-0.4	1.1
Impedance of whole body	0.3	1.5	6.4	-2.5	-0.7	-0.4	0.4	1.2	0.6
Leg fat mass (left)	0.6	2.5	6.8	2.6	1.1	2.0	-0.9	-1.3	-0.7
Arm predicted mass (left)	0.6	3.2	9.6	3.1	0.0	1.4	-1.2	-1.9	-1.6