Best TWAS P=1.51e-12 · Best GWAS P=2.46e-12 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | CALCRL | 0.16 | 0.17 | lasso | 2 | 0.15 | 8.4e-09 | -6.8 | -7.0 | 1.9e-12 | 0.87 | 0.05 | 0.95 | FALSE |
| 2 | GTEx | Artery Tibial | CALCRL | 0.27 | 0.33 | lasso | 3 | 0.32 | 1.1e-25 | -6.8 | -7.0 | 2.8e-12 | 0.81 | 0.05 | 0.95 | FALSE |
| 3 | GTEx | Brain Frontal Cortex BA9 | AC007319.1 | 0.16 | 0.08 | lasso | 7 | 0.10 | 9.9e-04 | -6.9 | -6.8 | 7.5e-12 | 0.90 | 0.06 | 0.84 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | TFPI | 0.07 | 0.04 | lasso | 4 | 0.03 | 1.6e-03 | -6.3 | -6.7 | 1.7e-11 | 0.83 | 0.03 | 0.94 | FALSE |
| 5 | GTEx | Nerve Tibial | CALCRL | 0.09 | 0.04 | enet | 9 | 0.08 | 5.2e-06 | -6.7 | -6.3 | 3.6e-10 | 0.75 | 0.07 | 0.86 | FALSE |
| 6 | GTEx | Skin Not Sun Exposed Suprapubic | AC007319.1 | 0.17 | 0.10 | lasso | 3 | 0.13 | 1.9e-07 | -5.1 | -5.6 | 1.8e-08 | 0.82 | 0.07 | 0.93 | FALSE |
| 7 | NTR | Blood | CALCRL | 0.02 | 0.03 | lasso | 7 | 0.02 | 3.6e-08 | -6.7 | 6.7 | 2.2e-11 | -0.88 | 0.08 | 0.92 | FALSE |
| 8 | The Cancer Genome Atlas | Colon Adenocarcinoma | TFPI | 0.08 | 0.04 | blup | 51 | 0.03 | 6.0e-03 | -5.1 | -5.4 | 6.5e-08 | 0.74 | 0.03 | 0.34 | FALSE |
| 9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CALCRL | 0.03 | 0.04 | blup | 62 | 0.04 | 1.4e-05 | -7.0 | 7.1 | 1.5e-12 | -0.95 | 0.02 | 0.98 | TRUE |