Best TWAS P=2.21e-08 · Best GWAS P=1.92e-08 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | HSPD1 | 0.08 | 0.09 | lasso | 7 | 0.09 | 2.2e-11 | -5.5 | -5.6 | 2.3e-08 | 0.97 | 0.04 | 0.96 | FALSE |
| 2 | GTEx | Brain Frontal Cortex BA9 | MARS2 | 0.18 | 0.12 | lasso | 2 | 0.07 | 5.1e-03 | -5.6 | 5.6 | 2.2e-08 | -1.00 | 0.04 | 0.73 | TRUE |
| 3 | GTEx | Cells EBV-transformed lymphocytes | HSPD1 | 0.15 | 0.04 | lasso | 7 | 0.04 | 2.0e-02 | -5.3 | 5.4 | 7.5e-08 | -0.92 | 0.05 | 0.82 | FALSE |
| 4 | METSIM | Adipose | HSPD1 | 0.02 | 0.00 | blup | 323 | 0.01 | 1.8e-02 | -4.1 | 5.4 | 7.1e-08 | -0.82 | 0.08 | 0.66 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RFTN2 | 0.02 | 0.02 | lasso | 2 | 0.01 | 1.1e-03 | -5.5 | -5.5 | 3.0e-08 | 0.98 | 0.01 | 0.96 | FALSE |
| 6 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | COQ10B | 0.05 | 0.04 | lasso | 2 | 0.04 | 1.5e-03 | -5.2 | -5.2 | 2.4e-07 | 0.84 | 0.01 | 0.81 | FALSE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | COQ10B | 0.03 | 0.02 | enet | 9 | 0.02 | 1.7e-03 | -5.2 | 5.2 | 2.6e-07 | -0.85 | 0.01 | 0.91 | FALSE |