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chr2:201,282,338-204,330,528

Best TWAS P=1.72e-12 · Best GWAS P=2.75e-11 conditioned to 0.0652

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Visceral Omentum	ALS2	0.24	0.12	enet	22	0.15	2.4e-08	-4.7	5.6	1.8e-08	-0.15	0.95	0.01	TRUE
2	GTEx	Adipose Visceral Omentum	CASP8	0.20	0.16	lasso	7	0.15	2.7e-08	-5.1	5.3	8.8e-08	-0.53	0.81	0.18	FALSE
3	GTEx	Artery Coronary	STRADB	0.29	0.03	lasso	11	0.09	5.8e-04	-6.7	6.1	1.1e-09	-0.97	0.01	0.83	FALSE
4	GTEx	Brain Cerebellar Hemisphere	CASP8	0.58	0.50	lasso	3	0.46	1.9e-13	-5.6	-5.3	9.5e-08	0.53	0.75	0.25	FALSE
5	GTEx	Brain Cerebellum	CASP8	0.44	0.47	enet	7	0.46	4.2e-15	-5.1	-5.4	7.3e-08	0.54	0.86	0.14	FALSE
6	GTEx	Brain Frontal Cortex BA9	CASP8	0.13	0.24	lasso	1	0.21	3.1e-06	-5.6	-5.6	2.2e-08	0.53	0.18	0.34	FALSE
7	GTEx	Brain Frontal Cortex BA9	ALS2CR12	0.26	0.29	enet	8	0.24	5.1e-07	-4.5	-5.3	1.1e-07	0.58	0.10	0.84	FALSE
8	GTEx	Brain Hypothalamus	ENO1P4	0.33	0.02	lasso	13	0.00	3.9e-01	-6.7	6.5	9.8e-11	-0.67	0.04	0.42	FALSE
9	GTEx	Brain Nucleus accumbens basal ganglia	ALS2CR12	0.15	0.15	lasso	8	0.14	1.6e-04	-5.4	-5.5	4.6e-08	0.56	0.16	0.45	FALSE
10	GTEx	Breast Mammary Tissue	CASP8	0.29	0.18	lasso	6	0.20	2.7e-10	-4.5	5.3	1.1e-07	-0.57	0.60	0.40	FALSE
11	GTEx	Breast Mammary Tissue (Female)	ALS2	0.27	0.16	enet	28	0.10	8.5e-04	-4.7	5.2	1.8e-07	-0.29	0.52	0.09	FALSE
12	GTEx	Breast Mammary Tissue (Female)	CASP8	0.20	0.24	lasso	4	0.22	3.5e-07	-5.4	5.5	4.7e-08	-0.56	0.07	0.86	FALSE
13	GTEx	Cells Transformed fibroblasts	STRADB	0.07	0.02	lasso	4	0.02	1.4e-02	-5.4	-5.6	1.8e-08	0.53	0.13	0.18	FALSE
14	GTEx	Colon Transverse	CASP8	0.21	0.13	lasso	7	0.17	2.1e-08	-4.5	5.4	8.0e-08	-0.54	0.84	0.15	FALSE
15	GTEx	Esophagus Mucosa	CASP10	0.40	0.36	enet	36	0.36	1.1e-24	5.6	-5.7	9.4e-09	0.82	0.56	0.44	FALSE
16	GTEx	Esophagus Mucosa	ALS2CR12	0.09	0.03	lasso	8	0.05	3.7e-04	-4.2	-5.3	8.6e-08	0.53	0.61	0.26	FALSE
17	GTEx	Lung	CASP8	0.18	0.18	enet	20	0.18	9.6e-14	-4.4	5.6	2.2e-08	-0.54	0.97	0.03	FALSE
18	GTEx	Nerve Tibial	STRADB	0.11	0.03	lasso	2	0.02	2.1e-02	-4.0	-5.9	4.3e-09	0.57	0.03	0.78	FALSE
19	GTEx	Pancreas	CASP8	0.16	0.15	lasso	5	0.13	4.1e-06	-5.4	5.4	6.8e-08	-0.59	0.07	0.92	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	CASP10	0.21	0.17	enet	13	0.17	1.2e-09	5.6	-5.5	4.7e-08	0.80	0.08	0.92	FALSE
21	GTEx	Skin Sun Exposed Lower leg	CASP10	0.10	0.09	lasso	5	0.08	6.0e-07	5.8	-5.3	1.2e-07	0.81	0.35	0.65	FALSE
22	GTEx	Testis	ALS2CR12	0.28	0.27	enet	11	0.28	9.4e-13	-4.5	-5.9	3.4e-09	0.69	0.56	0.44	FALSE
23	GTEx	Thyroid	ALS2CR12	0.19	0.12	enet	21	0.15	8.0e-12	-4.5	-5.2	2.1e-07	0.51	0.70	0.30	FALSE
24	GTEx	Whole Blood	CASP8	0.07	0.04	lasso	8	0.03	1.3e-03	-5.6	5.2	2.4e-07	-0.49	0.63	0.16	FALSE
25	YFS	Blood	CFLAR	0.15	0.17	lasso	7	0.17	9.3e-54	-4.9	5.2	2.3e-07	-0.69	0.98	0.02	FALSE
26	YFS	Blood	FAM117B	0.47	0.52	lasso	14	0.57	1.7e-231	-5.0	5.5	3.2e-08	0.04	0.00	0.99	TRUE
27	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ALS2CR12	0.07	0.03	blup	76	0.05	2.0e-03	-3.9	-5.4	7.3e-08	0.48	0.15	0.38	FALSE
28	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CASP8	0.09	0.09	lasso	2	0.08	8.6e-05	-5.1	5.1	2.9e-07	-0.50	0.24	0.39	FALSE
29	The Cancer Genome Atlas	Glioblastoma Multiforme	ALS2CR12	0.09	0.04	blup	76	0.04	2.2e-02	-4.5	-5.7	1.1e-08	0.55	0.03	0.32	FALSE
30	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CASP8	0.07	0.06	lasso	3	0.06	1.6e-07	-5.1	5.2	2.1e-07	-0.52	0.93	0.07	FALSE
31	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ALS2CR12	0.05	0.03	blup	76	0.05	2.8e-06	3.8	-5.1	2.7e-07	0.49	0.78	0.19	FALSE
32	The Cancer Genome Atlas	Brain Lower Grade Glioma	CASP10	0.02	0.01	enet	3	0.02	3.1e-03	-6.7	7.1	1.7e-12	-0.94	0.00	0.97	TRUE
33	The Cancer Genome Atlas	Lung Adenocarcinoma	CASP8	0.07	0.10	enet	11	0.10	2.3e-11	-5.1	5.3	1.1e-07	-0.53	0.96	0.04	FALSE
34	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CASP8	0.06	0.04	enet	8	0.06	5.1e-07	-5.1	5.4	7.4e-08	-0.53	0.86	0.13	FALSE
35	The Cancer Genome Atlas	Prostate Adenocarcinoma	ALS2CR12	0.06	0.06	enet	11	0.08	2.7e-08	-6.3	-6.6	4.3e-11	0.67	0.01	0.99	FALSE
36	The Cancer Genome Atlas	Soft Tissue Sarcoma	ALS2CR12	0.06	0.01	blup	76	0.03	4.4e-03	-5.6	-6.0	1.4e-09	0.64	0.02	0.78	FALSE
37	The Cancer Genome Atlas	Thyroid Carcinoma	CASP10	0.05	0.03	lasso	3	0.03	3.4e-04	-5.5	5.8	7.1e-09	-0.80	0.35	0.55	FALSE