Hub : Genes

COQ10B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Ovarian Serous Cystadenocarcinoma 0.053 0.043 0.0025 0.044 0.035 0.024 NA 0.037 0.00057 0.002 0.0086 NA 0.0015
2 TCGA Thyroid Carcinoma 0.025 0.018 0.0030 0.022 0.022 0.025 NA 0.021 0.00280 0.003 0.0017 NA 0.0038

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 6.2 9.9 10.7 -3.3 3.0
Bipolar Disorder or Schizophrenia 2.9 7.0 8.9 -3.0 2.3
Depressed Affect (Nagel 2018) 0.3 0.6 0.7 -0.8 0.7
Depression (Nagel 2018) 0.4 0.6 0.8 -0.6 0.9
Intelligence (Savage-Jansen 2018) 0.0 0.1 0.1 -0.4 0.0
Neuroticism (Nagel 2018) 0.2 0.5 0.6 -0.8 0.7
Schizophrenia (2018) 0.4 0.9 1.5 -1.2 0.5
Schizophrenia vs Biploar Disorder 7.7 10.1 11.8 2.9 -3.4
Worry (Nagel 2018) 0.7 1.4 1.4 -1.2 1.2
Alzheimer’s Disease (in mother) 0.1 0.2 0.2 0.4 -0.4
Alzheimer’s Disease (in father) 0.3 0.3 0.4 -0.5 0.6
Alzheimer’s Disease (including proxy) 0.1 0.1 0.2 0.4 -0.3
Crohns Disease (2017) 0.1 0.1 0.2 -0.5 -0.1
Irritable Bowel Disease (IBD) 1.6 3.9 4.7 -2.2 1.8
Ulcerative Colitis (UC) 4.5 8.4 8.6 -2.9 2.9
Major Depression (MDD) 0.0 0.0 0.0 -0.1 -0.1
Reaction Time 0.9 1.6 2.0 1.1 -1.4
Verbal and Numeric Reasoning (VNR) 0.0 0.1 0.1 0.0 -0.4
Breast Cancer 3.1 7.5 7.5 2.7 -2.7
Ovarian Cancer 0.1 0.1 0.1 0.3 -0.3
Prostate Cancer 0.0 0.0 0.0 0.1 0.1
Age at First Birth 0.2 0.3 0.4 0.6 -0.6
Bipolar Disorder (2011) 0.3 0.3 0.4 -0.7 0.4
Body Mass Index (BMI) (2010) 3.1 4.2 4.5 -2.1 2.0
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 -0.2
Crohns Disease (2012) 0.1 0.2 0.3 -0.2 -0.6
Mean Putamen Volume 0.6 0.7 0.9 0.7 -0.9
Fasting Glucose 1.0 1.2 1.3 -1.1 1.1
HbA1C 0.0 0.0 0.0 0.2 0.1
HDL Cholesterol 0.8 1.4 1.6 1.3 -1.1
LDL Cholesterol 0.5 0.7 0.8 -0.9 0.8
Lupus 0.0 0.0 0.0 0.2 -0.1
Neuroticism (2016) 0.1 0.2 0.2 -0.5 0.5
Primary Biliary Cirrhosis 0.3 0.4 0.6 -0.5 0.8
Rheumatoid Arthritis 0.1 0.1 0.3 0.5 -0.1
Schizophrenia (2014) 0.8 1.8 3.0 -1.7 0.8
Triglycerides 0.8 1.3 1.5 -1.2 1.0
Type 2 Diabetes (T2D) (2012) 1.1 1.2 1.5 1.2 -1.0
Ulcerative Colitis 7.3 10.6 11.6 -3.4 3.1
Blood Eosinophil Count 0.0 0.1 0.2 -0.5 -0.2
Blood Platelet Count 2.5 28.9 32.9 5.7 -5.0
Blood Red Count 0.2 1.6 2.6 -0.8 1.6
Blood White Count 3.6 26.6 26.7 -5.2 5.2
Heel T-Score 0.9 7.3 7.6 -2.6 2.8
BMI 5.3 31.0 33.5 -5.3 5.8
Height 1.7 32.4 33.8 5.6 -5.8
Waist Hip Ratio (WHR) 0.0 0.1 0.2 -0.3 -0.5
Systolic Blood Pressure 1.3 6.4 7.0 2.4 -2.6
Smoking Status 2.8 6.6 7.0 -2.6 2.5
Allergy or Eczema 0.2 0.6 0.9 -0.9 -0.5
Cardiovascular Disease 0.6 2.1 2.5 -1.3 1.6
Hypothyroidism (self reported) 0.4 0.9 1.2 -0.7 1.1
Respiratory disease 0.3 0.6 1.1 0.4 -1.0
Type 2 Diabetes (T2D) (2018) 2.1 3.9 4.3 -1.9 2.1
Lung FEV1/FVC ratio 4.0 20.2 20.5 -4.5 4.5
Lung FVC 0.1 0.3 0.4 -0.5 0.6
Neuroticism 0.6 1.4 1.7 -1.3 1.1
Chronotype (morning person) 1.3 3.1 4.3 -1.4 2.1
Hair Pigment 0.1 3.2 3.3 1.8 -1.8
Tanning 0.1 1.1 1.4 1.2 -0.9
Hand grip strength (left) 0.6 1.7 1.8 1.3 -1.3
Number of treatments/medications taken 0.2 0.4 0.4 -0.7 0.6
Average weekly spirits intake 0.2 0.3 0.5 0.7 -0.2
Sensitivity / hurt feelings 0.6 1.0 1.3 -1.1 0.9
Frequency of depressed mood in last 2 weeks 1.3 1.8 2.1 -1.3 1.4
Hearing difficulty/problems: Yes 2.7 4.1 4.2 -2.0 2.1
Relative age of first facial hair 0.7 1.3 1.5 -1.1 1.2
Other serious medical condition/disability diagnosed by doctor 0.0 0.0 0.1 -0.0 0.3
Ever used hormone-replacement therapy (HRT) 1.9 2.4 2.9 -1.4 1.7
Ever had hysterectomy (womb removed) 0.7 0.8 1.0 -0.8 1.0
Systolic blood pressure, automated reading 0.3 0.8 1.1 0.8 -1.0
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.2 0.5 -0.3
Angina 10.4 13.6 14.0 -3.6 3.7
Medication for hormone replacement therapy 0.8 0.9 1.1 1.1 -0.8
Vitamin and mineral supplements 2.2 3.0 3.8 1.9 -1.5
Supplements: Zinc 1.4 1.6 1.7 -1.3 1.2
Medication: Co-codamol 0.3 0.4 0.4 -0.7 0.6
Medication: Metformin 2.3 3.3 3.6 -1.7 1.9
Diabetes (father) 0.9 1.1 1.3 -1.0 1.1
Diabetes (mother) 3.9 5.0 5.5 -2.1 2.3
Severe depression (siblings) 0.2 0.2 0.2 0.4 -0.5
Pack years adult smoking proportion 3.0 4.5 4.6 -2.1 2.1
Impedance of leg (right) 3.8 18.4 22.3 3.8 -4.7
Leg fat-free mass (left) 1.4 7.2 8.2 -2.5 2.9
Trunk fat percentage 2.7 10.8 13.3 -3.6 2.9
Hand grip strength (right) 0.4 1.0 1.1 1.1 -0.9
Townsend deprivation index at recruitment 0.1 0.1 0.1 0.3 -0.3
Current tobacco smoking 0.2 0.4 0.4 -0.6 0.6
Average weekly fortified wine intake 0.2 0.2 0.3 -0.5 0.5
Maternal smoking around birth 0.2 0.3 0.3 -0.6 0.6
Fed-up feelings 0.1 0.1 0.2 0.4 -0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 1.5 2.0 2.5 -1.3 1.6
Relative age voice broke 0.3 0.4 0.6 0.7 -0.5
Taking other prescription medications 0.1 0.1 0.2 0.1 -0.5
Age when periods started (menarche) 0.2 0.4 0.5 0.7 -0.6
Bilateral oophorectomy (both ovaries removed) 1.1 1.3 1.3 -1.1 1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.2 -0.3 0.4
Tinnitus: Yes, but not now, but have in the past 0.5 0.6 0.6 -0.7 0.8
Qualifications: CSEs or equivalent 0.1 0.2 0.2 -0.3 0.5
Serious illness, injury or assault to yourself 0.5 0.6 0.6 -0.8 0.8
High blood pressure 0.6 1.7 1.7 -1.3 1.3
Hayfever, allergic rhinitis or eczema 0.2 0.4 0.6 -0.8 -0.4
Multivitamins +/- minerals 0.4 0.5 0.7 -0.8 0.6
Stomach or abdominal pain in last month 0.0 0.0 0.0 -0.1 0.2
Supplements: Glucosamine 0.5 0.6 0.9 0.6 -0.9
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.4 -0.6 0.3
Medication: Atenolol 0.1 0.1 0.2 -0.4 0.1
Medication: Levothyroxine sodium 1.0 1.7 2.2 -1.0 1.5
Sitting height 0.0 0.1 0.2 0.2 -0.4
Chronic bronchitis/emphysema (father) 0.1 0.1 0.1 -0.3 0.2
High blood pressure (mother) 1.4 2.0 2.2 -1.5 1.4
Body mass index (BMI) 5.6 23.9 25.3 -4.7 5.0
Impedance of leg (left) 3.7 18.1 21.5 3.8 -4.6
Leg predicted mass (left) 1.4 7.5 8.5 -2.5 2.9
Trunk fat mass 1.9 8.1 9.4 -3.1 2.6
Waist circumference 3.2 11.7 12.6 -3.5 3.3
Number of incorrect matches in round 0.2 0.4 0.4 -0.6 0.6
Past tobacco smoking 1.3 2.4 2.6 1.6 -1.4
Alcohol usually taken with meals 0.2 0.3 0.5 -0.7 0.4
Nervous feelings 1.7 3.1 3.2 -1.8 1.8
Frequency of tenseness / restlessness in last 2 weeks 0.6 1.0 1.4 -0.7 1.2
Hearing difficulty/problems with background noise 2.7 4.3 4.6 -2.1 2.0
Hair/balding pattern: Pattern 2 0.1 0.1 0.2 -0.4 0.1
Had menopause 1.1 1.4 1.6 -1.3 1.1
Had other major operations 0.3 0.4 0.5 -0.7 0.5
Forced vital capacity (FVC) 1.1 4.3 4.4 2.1 -2.0
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 0.5 -0.7 0.7
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 0.3 -0.5 0.6
Qualifications: None of the above 0.8 1.7 1.8 -1.3 1.4
Financial difficulties in last 2 years 0.4 0.6 0.7 -0.8 0.7
Mouth/teeth dental problems 0.7 1.1 1.5 1.2 -0.9
Heart attack 4.1 5.3 5.3 -2.3 2.3
Allergy 0.8 1.8 3.1 1.8 -0.7
Pain all over the body in last month 0.1 0.1 0.1 0.3 -0.2
Diabetes (self-reported) 0.5 0.8 0.8 -0.9 0.9
Hayfever/allergic rhinitis (self-reported) 3.2 4.2 5.5 1.7 -2.3
Medication: Ramipril 0.1 0.1 0.1 -0.1 0.3
Medication: Simvastatin 0.6 0.8 0.9 -1.0 0.9
Fluid intelligence score 0.7 1.4 1.9 1.0 -1.4
Illnesses of siblings 0.1 0.2 0.2 0.4 -0.4
Neuroticism score 0.8 1.6 1.8 -1.4 1.1
Weight 1.8 8.9 9.4 -2.9 3.1
Impedance of arm (right) 0.8 3.8 6.8 0.9 -2.6
Arm fat percentage (right) 5.0 19.8 22.3 -4.7 4.2
Trunk fat-free mass 0.1 0.4 0.9 -0.2 0.9
Hip circumference 2.0 8.6 9.1 -3.0 2.9
Time employed in main current job 4.5 5.2 5.8 -2.1 2.4
Alcohol intake versus 10 years previously 0.6 0.9 1.0 0.9 -1.0
Father’s age at death 0.0 0.1 0.1 -0.3 0.1
Worrier / anxious feelings 0.0 0.0 0.0 0.0 -0.1
Frequency of tiredness / lethargy in last 2 weeks 2.3 3.7 4.4 -1.7 2.1
Falls in the last year 0.5 0.7 1.0 -0.6 1.0
Hair/balding pattern: Pattern 3 0.7 1.0 1.3 -0.9 1.1
Number of live births 0.0 0.0 0.1 0.1 -0.2
Forced expiratory volume in 1-second (FEV1) 0.1 0.3 0.3 0.6 -0.5
Pulse rate 0.1 0.1 0.2 -0.5 0.0
Happiness 0.8 0.9 1.2 -0.8 1.1
Noisy workplace 0.1 0.1 0.2 0.4 -0.3
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.3 -0.5 0.5
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.4 0.3 -0.6
Mouth/teeth dental problems: Dentures 0.1 0.2 0.5 -0.7 0.2
Asthma 0.3 0.6 1.0 0.4 -1.0
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.2 0.3 -0.6 0.4
Medication: Cholesterol lowering 0.4 0.7 0.7 -0.8 0.8
Depression (self-reported) 0.9 1.0 1.2 -1.1 0.9
Medication: Lansoprazole 2.3 2.6 2.8 -1.6 1.7
Prospective memory result 0.1 0.1 0.1 -0.1 0.4
Lung cancer (father) 3.3 3.9 3.9 -2.0 2.0
Illnesses of mother 3.3 4.1 4.1 2.0 -2.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 0.5 0.7 -0.6
Pulse wave Arterial Stiffness index 3.5 4.0 4.3 -2.1 1.9
Impedance of arm (left) 0.9 4.1 7.1 1.0 -2.7
Arm fat mass (right) 4.5 18.6 19.2 -4.4 4.2
Trunk predicted mass 0.1 0.4 0.8 -0.1 0.9
Standing height 1.3 12.7 13.5 3.4 -3.7
Length of working week for main job 0.0 0.0 0.1 -0.0 0.3
Exposure to tobacco smoke at home 0.0 0.0 0.1 -0.0 0.3
Breastfed as a baby 0.1 0.1 0.1 -0.3 0.3
Tense / ‘highly strung’ 0.5 0.9 0.9 -1.0 0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 11.8 18.1 18.8 -4.3 4.2
Hair/balding pattern: Pattern 4 0.4 1.0 1.5 0.8 -1.2
Birth weight of first child 3.2 5.8 5.8 -2.4 2.4
Peak expiratory flow (PEF) 0.1 0.3 0.3 -0.6 0.4
Pulse wave reflection index 1.3 1.6 2.1 -1.1 1.4
Ever highly irritable/argumentative for 2 days 0.7 0.9 0.9 -0.9 0.9
Loud music exposure frequency 1.4 1.6 1.7 1.3 -1.2
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.3 -0.5 0.5
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 0.7 -0.8 0.6
Blood clot in the leg (DVT) 0.6 0.7 0.9 -0.8 0.9
Medication: Paracetamol 0.1 0.1 0.2 -0.4 0.2
Headache pain in last month 0.4 0.7 0.8 -0.8 0.9
Medication for cholesterol, blood pressure or diabetes 0.7 1.2 1.2 1.1 -1.1
Glaucoma (self-reported) 1.2 1.5 1.6 1.3 -1.1
Gout (self-reported) 0.1 0.1 0.2 -0.2 0.4
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 1.4 -0.8 1.2
Medication: Amlodipine 2.6 3.6 3.9 -1.8 2.0
Medication: Ventolin 100micrograms inhaler 0.5 0.7 1.0 0.6 -1.0
Birth weight 1.2 2.5 3.1 -1.4 1.8
Chronic bronchitis/emphysema (mother) 0.5 0.6 0.7 -0.8 0.8
High blood pressure (siblings) 0.8 1.2 1.3 -1.0 1.1
Forced vital capacity (FVC), Best measure 1.5 5.5 5.8 2.4 -2.3
Body fat percentage 2.9 11.6 13.6 -3.7 3.1
Leg fat percentage (right) 1.7 6.0 6.6 -2.6 2.4
Arm fat-free mass (right) 0.3 1.8 2.9 -0.8 1.7
Exposure to tobacco smoke outside home 5.9 7.9 9.0 -2.6 3.0
Comparative body size at age 10 2.1 5.8 7.0 -2.1 2.6
Number of full brothers 0.0 0.0 0.0 0.2 -0.0
Worry too long after embarrassment 0.1 0.1 0.1 -0.4 0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 5.3 6.9 7.1 -2.7 2.6
Wheeze or whistling in the chest in last year 0.0 0.1 0.1 -0.4 0.1
Number of children fathered 0.0 0.0 0.0 0.1 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 1.4 1.6 1.7 1.3 -1.3
Age at first live birth 1.7 3.0 3.6 1.6 -1.9
Pulse wave peak to peak time 4.4 5.2 5.4 2.3 -2.2
Health satisfaction 1.6 2.0 2.3 -1.3 1.5
Shortness of breath walking on level ground 3.9 4.6 4.9 -2.1 2.2
Qualifications: College or University degree 0.9 3.0 3.3 1.8 -1.6
Eye problems/disorders: None of the above 0.1 0.1 0.1 0.2 -0.3
Mouth/teeth dental problems: Loose teeth 2.5 3.0 3.5 -1.6 1.9
Emphysema/chronic bronchitis 1.9 2.2 2.4 -1.6 1.4
Medication for pain relief, constipation, heartburn 2.3 3.9 4.1 2.0 -1.9
Neck or shoulder pain in last month 3.4 4.9 5.5 -2.1 2.3
Medication: Blood pressure 1.6 2.8 2.8 -1.7 1.7
Angina (self-reported) 11.3 14.8 15.3 -3.8 3.9
Migraine (self-reported) 0.7 0.8 0.9 1.0 -0.9
Medication: Ibuprofen 0.2 0.3 0.3 -0.6 0.4
Medication: Allopurinol 0.1 0.1 0.2 0.4 -0.2
Medication: Omeprazole 0.5 0.6 0.8 0.7 -0.9
Medication: Seretide 50 evohaler 0.0 0.1 0.1 -0.3 0.1
Mean time to correctly identify matches 1.3 2.5 2.9 1.4 -1.7
Heart disease (mother) 3.7 4.6 4.7 -2.2 2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 1.0 1.2 0.9 -1.1
Whole body fat mass 2.3 9.7 10.6 -3.3 3.0
Leg fat mass (right) 2.1 8.1 8.2 -2.9 2.8
Arm predicted mass (right) 0.4 1.9 3.1 -0.9 1.8
Pulse rate, automated reading 0.0 0.0 0.0 -0.1 -0.1
Alcohol intake frequency. 0.0 0.0 0.0 0.1 -0.0
Comparative height size at age 10 0.0 0.1 0.1 0.3 -0.1
Number of full sisters 0.5 0.6 0.9 -0.6 0.9
Suffer from ‘nerves’ 1.4 2.3 2.4 -1.5 1.5
Overall health rating 1.9 4.1 5.1 -1.8 2.2
Chest pain or discomfort 0.1 0.1 0.1 -0.4 0.3
Had major operations 0.3 0.4 0.5 -0.6 0.7
Age at last live birth 0.9 1.3 1.6 1.0 -1.3
Family relationship satisfaction 1.2 1.5 1.5 -1.2 1.2
Leg pain on walking 2.4 3.1 3.1 -1.7 1.8
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.3 0.5 -0.5
Commuting to job workplace: Car/motor vehicle 1.5 1.7 1.9 -1.2 1.4
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.1 0.3 -0.3
Medication: Aspirin 2.6 3.5 3.8 -1.8 2.0
Supplements: Vitamin C 3.0 3.6 3.8 -1.9 1.9
Knee pain experienced in last month 1.7 2.7 3.1 -1.5 1.8
Hypertension (Self-reported) 1.3 3.7 3.9 -1.9 2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 0.4 0.6 -0.6
Illnesses of father: Heart disease 0.1 0.2 0.3 0.3 -0.6
Illnesses of siblings: Diabetes 1.6 2.0 2.2 -1.5 1.4
Smoking status: Previous 1.1 1.6 1.6 -1.3 1.3
Forced expiratory volume in 1-second (FEV1), predicted 0.0 0.0 0.0 0.0 0.1
Whole body fat-free mass 0.4 2.2 3.2 -1.1 1.8
Leg fat-free mass (right) 1.4 7.3 8.5 -2.5 2.9
Arm fat percentage (left) 4.8 19.3 21.6 -4.7 4.1
Average weekly red wine intake 1.0 1.5 1.6 -1.3 1.1
Handedness (chirality/laterality): Left-handed 2.1 2.5 2.8 -1.7 1.5
Mood swings 1.5 2.7 2.8 -1.7 1.6
Loneliness, isolation 1.7 2.3 2.4 -1.6 1.5
Long-standing illness, disability or infirmity 0.1 0.1 0.2 -0.3 0.5
Ever had bowel cancer screening 2.0 2.4 2.6 -1.6 1.5
Diabetes diagnosed by doctor 0.8 1.4 1.5 -1.1 1.2
Ever had stillbirth, spontaneous miscarriage or termination 0.9 1.0 1.1 0.9 -1.0
Friendships satisfaction 6.0 7.4 7.6 -2.8 2.7
Qualifications: nursing, teaching 0.3 0.4 0.5 0.6 -0.7
Commuting to job workplace: Walk 0.3 0.3 0.3 0.5 -0.5
Eye problems/disorders: Cataract 2.5 2.9 2.9 -1.7 1.7
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.5 0.7 -0.3
Medication for cholesterol 1.2 1.8 2.2 1.2 -1.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.1 0.4 -0.1
Back pain experienced in last month 1.0 1.5 2.0 -1.0 1.4
Mineral and other dietary supplements 1.7 2.3 2.6 -1.4 1.6
Breast cancer (self-reported) 0.0 0.0 0.0 -0.0 0.0
Asthma (self-reported) 0.1 0.1 0.2 -0.1 -0.5
Osteoporosis (self-reported) 1.1 1.4 2.0 -1.4 0.9
Osteoarthritis (self-reported) 0.3 0.4 0.4 -0.6 0.6
Medication: Aspirin 3.2 4.2 4.5 -2.0 2.1
Medication: Gliclazide 0.0 0.0 0.0 -0.1 0.1
Illnesses of father: None of the above (group 1) 0.1 0.1 0.2 -0.0 0.4
Smoking status: Current 0.4 0.7 0.7 -0.8 0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.1 0.2 -0.2 0.4
Whole body water mass 0.4 2.2 3.2 -1.1 1.8
Leg predicted mass (right) 1.4 7.4 8.6 -2.5 2.9
Arm fat mass (left) 4.2 17.4 18.1 -4.3 4.1
Number of self-reported non-cancer illnesses 1.4 2.4 2.9 -1.7 1.4
Average weekly champagne plus white wine intake 0.9 1.2 1.3 -1.2 1.1
Miserableness 0.1 0.2 0.3 -0.5 0.3
Guilty feelings 0.0 0.0 0.0 0.0 0.0
Wears glasses or contact lenses 0.4 0.4 0.5 0.6 -0.7
Ever taken oral contraceptive pill 0.7 0.8 0.8 0.9 -0.9
Hearing aid user 0.7 0.8 0.8 -0.9 0.9
Mother’s age at death 0.0 0.0 0.1 0.1 -0.3
Financial situation satisfaction 0.1 0.2 0.2 0.5 -0.3
Tinnitus: Yes, now most or all of the time 4.3 5.0 5.4 -2.3 2.2
Commuting to job workplace: Public transport 2.9 3.5 3.5 1.9 -1.8
Eye problems/disorders: Glaucoma 0.6 0.8 0.9 0.9 -0.8
Medication: Blood pressure 1.3 2.5 2.7 -1.5 1.6
Pain type(s) experienced in last month: Hip pain 1.3 1.6 1.9 -1.1 1.4
Supplements: Fish oil (including cod liver oil) 0.1 0.2 0.2 0.4 -0.4
High cholesterol (Self-reported) 0.0 0.0 0.1 0.3 -0.0
Medication: Bendroflumethiazide 0.7 1.0 1.3 -0.9 1.1
Medication: Paracetamol 0.2 0.4 0.5 -0.7 0.5
Medication: Lisinopril 0.2 0.2 0.2 -0.4 0.5
Medication: Atorvastatin 0.3 0.4 0.6 -0.5 0.7
Illnesses of father: High blood pressure 0.2 0.3 0.4 -0.7 0.4
Alcohol drinker status: Never 0.2 0.2 0.3 0.5 -0.3
Ever smoked 0.6 1.0 1.2 -1.1 0.9
Basal metabolic rate 0.8 4.3 5.5 -1.8 2.3
Leg fat percentage (left) 1.7 6.1 6.5 -2.5 2.4
Arm fat-free mass (left) 0.5 2.5 3.8 -1.1 1.9
Number of operations (self-reported) 0.1 0.2 0.3 -0.5 0.4
Average weekly beer plus cider intake 0.3 0.4 0.5 0.7 -0.5
Irritability 0.1 0.1 0.3 -0.5 0.1
Risk taking 0.1 0.1 0.2 0.3 -0.4
Ever had prostate specific antigen (PSA) test 0.0 0.0 0.0 0.1 -0.2
Fractured/broken bones in last 5 years 0.8 1.0 1.2 -1.1 0.9
Age started oral contraceptive pill 1.1 1.3 1.4 -1.2 1.1
Diastolic blood pressure, automated reading 2.4 7.3 7.6 2.7 -2.8
Ever depressed for a whole week 1.0 1.2 1.3 -1.1 1.1
Unable to work because of sickness or disability 0.8 1.1 1.7 1.3 -0.7
Commuting to job workplace: Cycle 1.2 1.5 1.6 1.2 -1.2
Myopia 0.6 0.8 1.0 -0.8 1.0
Vascular/heart problems diagnosed by doctor 1.1 3.0 3.1 1.7 -1.7
Cholesterol lowering medication 2.1 3.0 3.5 -1.6 1.9
Medication: Omeprazole (e.g. Zanprol) 0.0 0.0 0.0 -0.0 -0.2
Pain experienced in last month 2.5 4.2 4.6 1.9 -2.1
Supplements: Calcium 0.6 0.7 0.9 -0.9 0.7
Basal cell carcinoma (self-reported) 5.4 6.4 6.5 2.5 -2.5
Heart attack/myocardial infarction (self-reported) 4.7 6.1 6.1 -2.5 2.5
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 0.9 -0.8 1.0
Heart disease (siblings) 0.0 0.0 0.1 -0.2 0.2
Alcohol drinker status: Previous 0.5 0.5 0.8 0.9 -0.5
Pack years of smoking 3.1 4.6 4.8 -2.1 2.2
Impedance of whole body 2.4 12.3 17.1 2.7 -4.1
Leg fat mass (left) 2.1 8.2 8.3 -2.9 2.9
Arm predicted mass (left) 0.6 2.8 4.2 -1.2 2.0