TWAS hub - HIP1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1400	0.0460	6.0e-04	0.030	NA	0.030	NA	0.004	1.5e-03	NA	1.7e-03	NA	1.3e-01
2	GTEx	Artery Aorta	0.0950	0.0400	4.6e-03	0.088	NA	0.034	NA	0.066	1.5e-05	NA	5.6e-03	NA	1.6e-04
3	GTEx	Esophagus Muscularis	0.0690	0.0310	2.5e-03	0.029	NA	-0.004	NA	-0.004	6.5e-03	NA	7.5e-01	NA	6.6e-01
4	GTEx	Lung	0.2169	0.0566	1.7e-06	0.063	NA	0.104	NA	0.072	1.3e-05	NA	2.5e-08	NA	3.7e-06
5	GTEx	Nerve Tibial	0.1332	0.0482	3.2e-03	0.046	NA	0.041	NA	0.018	3.4e-04	NA	6.9e-04	NA	1.9e-02
6	GTEx	Skin Sun Exposed Lower leg	0.1980	0.0610	1.5e-04	0.014	NA	0.036	NA	0.011	2.1e-02	NA	5.3e-04	NA	3.6e-02
7	GTEx	Thyroid	0.1520	0.0430	4.9e-05	0.127	NA	0.112	NA	0.046	6.5e-10	NA	6.4e-09	NA	1.8e-04
8	GTEx	Whole Blood	0.1300	0.0380	1.5e-06	0.089	NA	0.070	NA	0.071	1.3e-08	NA	4.7e-07	NA	4.0e-07
9	NTR	Blood	0.3217	0.0346	0.0e+00	0.364	0.337	0.364	0.366	0.366	1.3e-124	2.8e-113	2.2e-124	1.8e-125	3.5e-125
10	YFS	Blood	0.6312	0.0259	0.0e+00	0.565	0.528	0.569	0.569	0.568	3.8e-230	8.3e-208	9.6e-233	5.5e-233	5.5e-232
11	TCGA	Head and Neck Squamous Cell Carcinoma	0.0285	0.0151	3.2e-04	0.037	0.032	0.029	NA	0.029	4.4e-05	1.3e-04	3.1e-04	NA	3.2e-04
12	TCGA	Lung Squamous Cell Carcinoma	0.0260	0.0153	2.5e-03	0.021	0.019	0.013	NA	0.015	1.6e-03	2.5e-03	1.0e-02	NA	7.5e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Reproduciblity of spirometry measurement using ERS/ATS criteria	5.6	6.7	11.3	-3.0	-3.4	-0.7	-2.5	-2.6	-2.2	-2.9	3.2	3.0	2.8	-1.9	-1.8
Tinnitus: Yes, but not now, but have in the past	5.2	5.6	10.3	2.3	2.1	-2.7	2.1	3.2	2.3	2.7	-2.5	-2.7	-2.8	0.6	0.9
Mean Putamen Volume	4.7	5.4	11.0	-2.0	-1.1	1.6	-2.9	-2.3	-1.2	-3.2	3.0	3.3	3.3	-0.6	-0.5
Crohns Disease (2012)	3.3	5.3	11.7	2.6	1.5	-0.0	2.8	2.5	1.6	3.4	-3.1	-2.8	-2.9	-0.2	-0.2
Tinnitus: Yes, now most or all of the time	3.2	3.7	6.8	-1.3	-0.5	0.2	-1.8	-2.1	-0.3	-2.6	2.6	2.6	2.5	-2.3	-1.7
Reaction Time	2.8	5.3	8.6	2.6	2.9	-0.6	2.6	2.3	1.6	2.1	-2.9	-2.9	-2.6	1.4	1.8
Medication: Omeprazole (e.g. Zanprol)	2.6	3.2	11.6	-1.3	-1.4	-0.4	-1.9	-1.3	-0.8	-1.9	1.9	1.3	1.4	-2.5	-3.4
Mouth/teeth dental problems: Bleeding gums	2.5	3.3	7.6	-1.4	-0.5	0.9	-2.8	-1.5	-0.7	-2.5	2.5	2.4	2.4	-1.0	-0.8
Number of children fathered	2.5	2.9	4.5	-1.4	-0.1	1.2	-2.0	-1.7	-2.1	-1.9	1.9	1.9	2.0	-1.5	-1.5
Medication: Seretide 50 evohaler	2.5	2.9	6.8	-1.8	-1.3	-0.0	-0.8	-1.9	-2.2	-1.4	1.9	1.2	1.4	-2.2	-2.6
Medication: Ramipril	2.4	3.1	10.0	1.2	3.2	0.2	1.3	2.0	0.3	2.0	-2.2	-2.1	-2.1	0.6	1.5
Worry too long after embarrassment	2.4	4.0	10.5	1.5	1.1	-0.5	2.0	2.2	2.8	1.6	-1.7	-1.5	-1.6	3.2	2.6
Mean time to correctly identify matches	2.4	4.6	8.5	2.4	2.9	-0.3	2.4	2.2	0.8	2.0	-2.7	-2.8	-2.5	1.4	1.6
Body Mass Index (BMI) (2010)	2.3	3.1	8.9	0.4	2.3	1.7	1.3	0.5	-1.0	1.1	-1.9	-1.8	-1.7	2.6	3.0
Crohns Disease (2017)	2.2	4.8	11.3	1.5	0.3	-0.1	3.4	2.3	2.1	3.2	-2.8	-2.5	-3.1	-0.5	-0.6
Noisy workplace	2.2	2.8	5.4	1.5	1.8	-1.5	0.8	1.7	2.1	1.7	-1.7	-1.0	-1.1	2.1	2.3
Medication: Omeprazole	2.2	2.7	9.6	-0.8	-1.1	-0.3	-1.7	-1.0	0.2	-1.9	1.8	1.1	1.4	-2.6	-3.1
High cholesterol (Self-reported)	2.2	3.9	9.9	-2.2	-1.3	2.6	-3.1	-1.4	-1.4	-2.0	1.9	2.1	2.3	-1.0	-1.2
Risk taking	2.2	3.2	7.1	-2.1	-1.0	0.1	-2.7	-2.0	-2.3	-1.5	1.8	2.1	2.0	-1.1	-1.1
Number of incorrect matches in round	2.1	3.4	8.9	-2.6	-1.5	0.1	-3.0	-2.7	-1.0	-1.7	1.7	2.1	2.3	0.1	0.2
Schizophrenia vs Biploar Disorder	2.0	2.6	4.7	-1.4	-1.9	0.4	-1.8	-1.7	-1.1	-1.8	1.9	2.0	2.2	-0.7	-1.5
Maternal smoking around birth	2.0	2.9	5.7	-1.8	-2.1	-2.0	-1.5	-1.7	-0.5	-2.2	2.4	1.5	1.5	-1.0	-1.1
Friendships satisfaction	2.0	2.4	6.4	1.3	1.1	0.5	1.6	1.9	0.8	1.3	-1.9	-1.3	-1.3	2.1	2.5
Unable to work because of sickness or disability	2.0	2.6	3.8	1.7	1.7	-0.2	1.5	1.9	1.2	1.4	-2.0	-1.9	-1.9	1.4	1.8
Age at First Birth	1.9	2.8	5.6	1.7	0.9	0.2	1.7	1.9	0.4	2.1	-2.2	-2.4	-2.3	-0.5	-1.6
Pulse rate, automated reading	1.9	6.2	10.2	1.0	2.3	0.1	2.4	2.9	2.8	3.2	-3.2	-2.6	-2.6	2.8	2.1
Eye problems/disorders: Glaucoma	1.8	2.1	4.4	-2.1	-1.8	-0.2	-2.1	-1.4	1.5	-0.9	1.5	1.7	1.7	-0.5	-0.4
Supplements: Fish oil (including cod liver oil)	1.8	2.4	8.6	-1.2	-1.9	2.9	-1.4	-0.3	-0.2	-1.5	1.3	1.8	1.9	1.3	0.7
Average weekly beer plus cider intake	1.8	2.7	21.5	0.7	0.6	-4.6	1.4	-0.2	-1.1	1.4	-0.8	-0.7	-1.2	0.7	1.2
Prostate Cancer	1.7	2.4	4.3	-1.3	-1.1	2.1	-0.6	-0.9	-0.8	-1.9	1.9	1.6	1.7	-2.1	-1.7
Triglycerides	1.7	2.7	4.5	1.6	1.1	1.9	1.9	2.1	0.9	1.5	-1.9	-1.7	-1.7	1.1	1.8
Illnesses of father: Heart disease	1.7	2.4	4.3	-1.7	-1.6	1.0	-1.2	-2.1	-1.4	-1.8	1.4	0.7	1.0	-1.9	-2.0
Long-standing illness, disability or infirmity	1.7	2.5	4.2	1.2	1.6	1.7	1.6	1.8	0.8	1.7	-2.0	-2.1	-1.9	1.2	1.0
Mother’s age at death	1.7	2.1	4.8	-1.5	0.3	1.3	-1.3	-1.9	-1.4	-1.5	1.6	1.9	2.2	0.9	0.2
Medication: Paracetamol	1.7	2.7	6.7	2.6	0.7	0.4	2.1	2.4	0.7	1.6	-1.7	-1.8	-2.1	-0.4	-0.7
Type 2 Diabetes (T2D) (2018)	1.6	2.9	7.8	0.6	1.3	1.7	1.5	2.8	2.3	1.6	-1.7	-1.8	-1.6	1.2	1.3
Relative age voice broke	1.6	2.5	9.1	-1.6	-0.5	1.5	-0.0	-1.2	3.0	-0.8	1.2	1.8	1.6	1.8	1.7
Supplements: Glucosamine	1.6	2.1	7.3	-0.8	-0.5	2.7	-1.7	-0.0	-1.2	-1.5	1.4	2.1	2.0	-0.2	-0.4
Lung cancer (father)	1.6	1.8	7.7	2.8	1.5	0.6	0.7	2.3	0.2	0.7	-1.1	-1.2	-1.1	0.8	0.8
High blood pressure (siblings)	1.6	2.4	5.9	0.0	2.1	1.0	1.1	0.6	-0.4	2.0	-2.4	-2.3	-2.2	0.9	0.4
Irritable Bowel Disease (IBD)	1.5	3.7	8.8	1.3	-0.3	1.6	3.0	2.4	1.6	2.7	-2.2	-2.1	-2.4	-0.5	-0.1
Multivitamins +/- minerals	1.5	1.9	5.5	-1.6	-0.9	-0.2	-0.8	-1.4	-0.1	-1.6	1.8	2.4	2.2	0.3	0.1
Hair/balding pattern: Pattern 3	1.5	2.2	9.1	0.2	2.1	0.6	0.8	-0.3	0.3	1.1	-1.3	-0.9	-0.7	3.0	2.8
Qualifications: College or University degree	1.5	4.7	11.7	1.1	0.9	2.6	2.5	1.8	3.4	2.9	-2.5	-2.4	-1.9	1.1	0.1
Wears glasses or contact lenses	1.5	1.7	7.2	-1.4	-1.1	2.7	-1.4	-0.8	0.7	-1.4	1.2	1.1	1.5	-0.2	0.2
Alcohol drinker status: Previous	1.5	1.8	3.7	0.4	1.9	-1.9	0.6	0.0	-0.8	1.8	-1.7	-1.7	-1.8	0.3	0.4
Type 2 Diabetes (T2D) (2012)	1.4	1.7	4.6	2.0	-0.2	0.1	2.1	2.1	-0.2	0.6	-0.8	-0.8	-0.9	1.4	1.5
Blood Eosinophil Count	1.4	10.6	48.7	-2.7	-0.3	-7.0	0.1	-3.7	-7.0	0.4	0.6	-0.3	-0.6	-1.2	-2.5
Blood Red Count	1.4	14.0	26.8	3.8	3.9	1.1	3.8	4.1	2.1	4.8	-4.7	-5.2	-4.9	1.2	1.9
Systolic Blood Pressure	1.4	7.1	13.5	2.5	3.1	-0.2	2.6	2.6	2.3	2.5	-2.8	-2.3	-2.5	3.5	3.7
Mouth/teeth dental problems: Dentures	1.4	2.3	4.4	1.3	1.0	-2.0	0.9	1.2	1.7	1.9	-1.9	-2.1	-2.0	-0.6	0.1
Depression (self-reported)	1.4	1.7	6.0	-2.4	-0.4	-1.3	-1.2	-1.7	0.4	-1.0	0.9	1.5	1.3	1.4	0.9
Had major operations	1.4	1.6	4.7	2.2	1.8	0.3	0.9	1.5	-1.4	1.2	-1.4	-1.1	-1.4	0.5	0.3
Leg predicted mass (right)	1.4	7.3	15.4	1.1	3.2	1.8	1.8	2.0	1.9	3.4	-3.7	-3.9	-3.6	1.5	2.3
Qualifications: CSEs or equivalent	1.3	1.7	4.3	-0.3	-0.6	-0.6	-1.1	-1.2	-2.1	-1.2	1.3	1.3	1.0	-1.9	-1.7
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	2.9	1.5	1.3	0.5	1.7	1.1	1.6	0.5	-0.6	-0.5	-0.6	1.7	1.6
Medication: Paracetamol	1.3	2.2	4.2	1.8	0.5	1.2	1.6	2.1	-0.2	1.4	-1.5	-1.7	-1.8	-1.0	-1.5
Eye problems/disorders: None of the above	1.3	1.5	9.1	1.1	0.0	1.2	0.7	-0.2	-3.0	-0.4	0.2	-0.5	-0.3	-1.9	-1.2
Leg fat-free mass (right)	1.3	7.2	15.3	1.1	3.3	1.8	1.8	2.0	1.8	3.3	-3.7	-3.9	-3.6	1.6	2.3
Diabetes diagnosed by doctor	1.3	2.1	6.0	0.4	0.5	1.4	1.2	2.4	1.7	1.7	-1.6	-1.7	-1.5	1.0	1.0
Neuroticism (2016)	1.2	1.7	3.8	0.8	0.8	-1.9	1.7	0.8	1.3	1.0	-1.0	-0.7	-1.1	1.9	1.5
Leg fat-free mass (left)	1.2	6.2	12.0	0.9	3.0	1.9	1.4	2.0	1.9	2.9	-3.3	-3.5	-3.2	1.7	2.5
Townsend deprivation index at recruitment	1.2	1.7	9.5	0.2	-0.1	-3.1	1.0	0.2	1.0	0.6	-0.8	-0.9	-1.4	1.6	1.6
Average weekly fortified wine intake	1.2	1.4	8.7	-0.1	-1.0	3.0	1.2	0.3	0.4	0.7	-1.0	-1.4	-1.0	-0.8	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	5.8	1.5	0.6	-2.4	0.8	0.1	-2.2	-0.1	-0.4	-0.9	-1.0	-1.3	-1.3
Stomach or abdominal pain in last month	1.2	1.4	3.7	1.0	1.1	0.1	1.3	1.3	1.9	1.5	-1.5	-1.3	-1.2	0.6	0.2
Medication: Atenolol	1.2	1.5	3.5	-1.2	-0.1	1.6	-1.6	-1.2	0.0	-1.4	1.5	1.4	1.9	-0.3	0.1
Leg predicted mass (left)	1.2	6.5	12.5	1.0	3.1	1.8	1.5	2.1	2.0	3.0	-3.4	-3.5	-3.3	1.8	2.6
Forced vital capacity (FVC)	1.2	4.6	10.5	1.8	1.6	-1.1	2.5	2.3	2.9	2.2	-1.8	-1.6	-1.9	1.7	3.2
Forced vital capacity (FVC), Best measure	1.2	4.5	13.1	1.6	1.0	-1.7	2.6	2.3	3.6	2.2	-1.9	-1.5	-1.9	1.4	2.5
Age at first live birth	1.2	2.0	6.5	1.0	0.9	0.6	1.3	1.7	2.5	1.6	-1.5	-1.0	-0.8	1.7	1.4
Medication: Ibuprofen	1.2	1.4	2.8	1.7	0.6	-1.5	1.4	1.0	0.5	1.5	-1.2	-1.5	-1.6	-0.4	0.1
Suffer from ‘nerves’	1.2	1.8	4.4	1.0	0.3	-1.8	2.0	1.3	2.1	0.8	-1.0	-0.8	-1.1	1.5	1.4
Supplements: Vitamin C	1.2	1.4	3.7	1.2	0.1	-1.1	0.8	1.6	-1.1	1.2	-1.3	-1.5	-1.9	-0.1	-0.4
Illnesses of father: High blood pressure	1.2	1.4	2.3	-0.8	-0.3	-1.4	-1.2	-1.5	-1.4	-1.4	0.9	1.1	0.9	-1.3	-1.5
Pack years of smoking	1.2	1.8	3.6	-1.9	-0.8	-0.1	-0.9	-1.6	-0.5	-1.7	1.8	1.9	1.8	0.3	-0.7
Breast Cancer	1.1	2.7	4.6	-1.7	-1.6	0.5	-1.1	-2.2	-1.6	-1.5	1.8	1.6	1.8	-1.5	-2.0
Ovarian Cancer	1.1	1.5	4.8	1.8	0.2	2.2	1.1	1.6	-1.2	0.7	-0.6	-1.4	-1.1	-0.4	-0.8
Primary Biliary Cirrhosis	1.1	1.5	3.7	0.1	-0.1	0.1	-1.5	0.0	-0.1	-1.5	1.9	1.8	1.8	-1.9	-0.7
BMI	1.1	6.3	13.5	0.7	3.0	3.7	0.6	2.5	1.3	2.3	-3.0	-3.7	-3.0	1.8	2.1
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	4.2	2.1	1.2	1.1	1.0	1.5	0.8	0.9	-0.8	-0.9	-0.8	-1.5	-0.7
Pain all over the body in last month	1.1	1.2	2.1	1.1	-0.3	-0.6	1.4	1.4	0.6	1.3	-1.3	-1.5	-1.4	0.6	0.2
Neuroticism score	1.1	2.4	15.4	0.6	0.8	-3.9	1.8	0.2	0.4	1.0	-1.2	-1.0	-1.6	1.2	1.0
Alcohol intake versus 10 years previously	1.1	1.6	5.8	0.2	-1.3	-2.4	-0.4	-0.5	-1.3	-0.3	0.3	-0.2	-0.4	-1.9	-2.4
Number of live births	1.1	1.6	3.5	-1.3	-0.3	-0.5	-1.7	-1.4	-0.4	-1.4	1.7	1.8	1.9	0.0	0.7
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	3.0	1.3	0.5	-0.8	1.6	1.0	0.4	1.5	-1.2	-1.7	-1.7	-1.0	-0.3
Loud music exposure frequency	1.1	1.2	3.7	-1.3	-0.8	-0.6	-1.0	-0.9	0.3	-0.1	0.5	1.3	1.1	1.9	1.7
Overall health rating	1.1	2.5	6.0	1.8	1.5	1.3	1.0	2.4	0.9	1.5	-2.0	-2.0	-2.1	0.3	0.3
Ever depressed for a whole week	1.1	1.4	3.4	1.7	0.5	-0.5	0.2	1.4	0.1	1.5	-1.7	-1.6	-1.8	0.4	0.5
Coronary Artery Disease (CAD)	1.0	1.1	3.2	-1.8	-1.3	-0.3	-1.5	-1.8	0.0	-1.0	0.8	0.6	0.8	0.2	-0.5
HbA1C	1.0	1.1	2.9	-0.3	-0.9	-0.3	-0.4	-1.2	-1.1	-1.0	1.3	0.9	0.8	-1.7	-1.7
Allergy or Eczema	1.0	2.5	9.8	1.3	3.1	-1.3	0.2	0.7	0.3	2.4	-1.9	-1.7	-1.5	1.0	1.1
Lung FVC	1.0	5.2	9.8	2.0	2.3	-0.3	2.2	3.1	1.8	2.6	-2.4	-2.4	-2.2	1.9	3.0
Average weekly spirits intake	1.0	1.2	3.8	-1.5	-0.5	0.4	-0.7	-1.0	-0.1	-0.9	1.2	1.0	1.0	-1.9	-1.4
Relative age of first facial hair	1.0	2.1	5.4	-2.3	0.1	-2.2	-0.5	-1.9	1.8	-0.4	0.9	1.7	1.3	1.1	1.2
Impedance of leg (right)	1.0	5.1	13.5	-0.8	-2.6	-3.3	-0.9	-1.0	0.5	-2.5	3.1	3.7	3.2	-0.6	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	5.5	1.0	1.3	0.4	0.8	0.8	0.1	1.9	-1.8	-1.6	-1.7	2.1	2.3
Had other major operations	1.0	1.2	3.5	1.6	0.8	-0.2	0.9	1.9	1.0	1.0	-0.8	-1.1	-1.3	-0.7	-0.8
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	2.6	1.6	0.7	-1.5	1.0	1.5	1.6	0.9	-0.7	-0.5	-0.8	0.7	1.1
Qualifications: None of the above	1.0	2.2	6.5	-1.2	-1.7	-2.5	-1.1	-1.7	-2.0	-0.9	1.0	0.6	0.1	-1.9	-1.6
Diabetes (self-reported)	1.0	1.6	4.8	0.5	1.0	1.1	1.1	2.2	1.5	1.4	-1.2	-1.4	-1.2	0.7	0.9
Hip circumference	1.0	4.1	9.4	-0.4	2.3	3.1	0.4	1.5	1.3	1.9	-2.6	-2.8	-2.4	1.7	1.9
Pulse wave reflection index	1.0	1.2	4.7	-0.5	0.2	-0.5	0.3	-1.0	-2.2	-0.3	0.3	-0.6	-0.4	-2.0	-1.8
Mouth/teeth dental problems: Loose teeth	1.0	1.2	4.4	0.6	-0.3	1.2	0.1	1.5	-0.1	0.4	-0.5	-0.9	-0.9	-2.0	-2.1
Emphysema/chronic bronchitis	1.0	1.2	3.1	0.8	0.5	1.1	1.4	1.8	1.6	0.9	-0.8	-1.1	-0.9	0.5	0.7
Average weekly red wine intake	1.0	1.4	9.0	-1.1	-0.6	2.1	-0.7	0.0	3.0	-0.2	0.2	0.5	0.7	0.8	0.4
Loneliness, isolation	1.0	1.4	12.2	-0.2	-0.0	-3.5	0.4	-0.9	-1.4	-0.0	-0.4	-0.2	-0.7	0.3	0.5
Mineral and other dietary supplements	1.0	1.4	5.8	0.5	0.7	-2.4	1.0	-0.2	-0.2	1.0	-0.8	-1.6	-1.6	-1.2	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	6.5	1.2	1.6	-0.6	0.7	1.5	0.6	1.7	-1.7	-1.4	-1.5	1.2	2.6
Ever had prostate specific antigen (PSA) test	1.0	1.1	3.8	1.9	1.7	-0.6	0.9	0.4	-0.9	0.8	-1.0	-1.0	-1.0	-0.4	-0.9
Intelligence (Savage-Jansen 2018)	0.9	2.9	7.9	-2.8	-1.6	1.3	-1.6	-2.5	-1.8	-1.1	1.4	1.6	1.6	-1.1	-1.2
Neuroticism (Nagel 2018)	0.9	2.0	14.1	0.2	1.1	-3.8	1.8	0.2	0.6	0.9	-0.9	-0.8	-1.5	0.1	0.8
Systolic blood pressure, automated reading	0.9	2.5	8.8	1.4	2.2	1.0	0.5	1.2	0.7	0.7	-1.2	-1.0	-0.9	2.8	3.0
Pack years adult smoking proportion	0.9	1.4	3.7	-1.9	-0.9	0.3	-0.7	-1.5	-0.4	-1.5	1.5	1.6	1.6	0.4	-0.6
Hayfever, allergic rhinitis or eczema	0.9	2.1	4.7	1.9	2.2	-1.0	1.0	1.3	0.7	2.0	-1.6	-1.7	-1.6	0.4	0.3
Alcohol usually taken with meals	0.9	1.5	10.6	-0.8	0.6	3.3	-1.1	0.9	1.3	-0.1	-0.1	0.7	1.1	1.0	0.5
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	5.6	2.4	0.3	1.3	0.7	1.9	0.6	0.6	-0.4	-1.0	-0.7	-0.4	0.0
Weight	0.9	4.3	10.2	0.3	2.4	2.3	0.9	1.5	1.4	2.1	-2.7	-3.2	-2.9	1.2	2.0
Falls in the last year	0.9	1.3	3.6	-1.4	-0.7	-1.1	-1.9	-1.0	-0.5	-1.0	1.2	1.2	1.2	-0.3	-1.2
Forced expiratory volume in 1-second (FEV1)	0.9	2.9	6.0	1.3	1.6	-1.3	1.6	1.9	2.4	1.9	-1.6	-1.5	-1.8	0.9	2.3
Breastfed as a baby	0.9	1.1	3.4	-1.3	-0.0	0.3	-1.4	-1.0	-1.8	-0.9	0.8	1.4	1.2	0.7	0.2
Chronic bronchitis/emphysema (mother)	0.9	1.0	9.3	-0.2	-0.7	-3.0	-0.4	-0.7	0.6	-0.4	0.6	0.5	0.3	0.7	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	6.2	0.2	-0.6	-2.5	-0.6	-0.8	0.6	-1.3	1.3	1.2	0.8	-0.1	0.6
Comparative height size at age 10	0.9	5.2	8.4	1.7	2.2	0.9	2.5	1.6	1.8	2.9	-2.9	-2.8	-2.6	1.8	2.6
Whole body fat-free mass	0.9	5.1	9.2	1.0	2.8	1.7	1.2	1.8	1.7	2.7	-3.0	-3.0	-2.8	1.5	2.6
Whole body water mass	0.9	5.1	9.2	1.1	2.8	1.7	1.2	1.8	1.8	2.7	-2.9	-3.0	-2.8	1.4	2.6
Guilty feelings	0.9	1.4	4.2	0.4	-0.1	-2.1	1.3	0.5	0.6	1.3	-1.3	-1.5	-1.8	0.1	-1.0
Ever taken oral contraceptive pill	0.9	1.0	4.2	-0.0	0.0	-1.4	0.1	0.5	2.1	0.6	-0.5	-0.2	-0.4	1.5	1.3
Hearing aid user	0.9	1.0	4.0	1.5	-0.7	-2.0	1.4	1.0	1.3	0.4	0.0	-0.1	-0.5	-0.1	-0.5
Basal metabolic rate	0.9	4.8	9.4	0.8	2.6	1.7	1.1	1.7	1.7	2.6	-2.9	-3.1	-2.8	1.4	2.5
Diastolic blood pressure, automated reading	0.9	2.7	10.9	-0.2	1.1	1.0	0.0	0.5	3.3	0.1	-0.3	-0.1	0.0	3.3	2.8
Commuting to job workplace: Cycle	0.9	1.1	2.4	1.4	1.1	-0.4	0.5	0.9	1.5	1.5	-1.2	-1.2	-1.1	0.4	0.4
Cholesterol lowering medication	0.9	1.3	2.7	-0.8	-1.3	1.4	-1.6	-0.8	-0.1	-1.0	1.0	1.0	1.2	-1.5	-1.1
Heart attack/myocardial infarction (self-reported)	0.9	1.1	2.9	0.8	-0.3	-1.0	-1.1	-0.9	-1.3	-1.7	1.5	1.1	1.1	-0.6	-0.4
Bipolar Disorder or Schizophrenia	0.8	2.1	4.7	-1.5	-2.2	-1.1	-1.2	-1.6	0.3	-1.5	1.6	1.0	1.1	-1.5	-1.8
Depression (Nagel 2018)	0.8	1.2	10.7	1.1	0.9	-3.3	0.2	0.2	-0.3	-0.4	0.3	-0.2	-0.5	-0.8	-0.2
Schizophrenia (2014)	0.8	1.7	6.7	-1.1	-2.6	0.4	-0.7	-1.2	0.7	-1.4	1.3	0.7	0.8	-1.4	-1.7
Nervous feelings	0.8	1.4	2.8	1.0	1.0	-1.5	1.7	0.7	0.9	1.2	-1.2	-0.9	-1.1	1.3	1.4
Mouth/teeth dental problems	0.8	1.2	3.6	-0.7	-0.9	1.1	0.1	-1.2	-1.9	-0.9	0.7	0.8	0.8	1.8	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.5	8.8	0.7	0.8	-1.8	1.4	1.5	3.0	1.8	-1.4	-1.1	-1.4	0.9	2.0
Exposure to tobacco smoke at home	0.8	0.9	2.2	-0.8	-1.3	-1.2	-0.7	-0.4	1.5	-0.5	1.2	1.0	0.9	0.1	0.0
Mood swings	0.8	1.4	6.4	-0.9	-0.0	-2.5	-0.1	-1.6	-0.3	-1.5	1.2	1.3	0.9	-0.7	-0.4
Average weekly champagne plus white wine intake	0.8	1.1	3.9	-0.1	-0.7	2.0	-0.5	0.7	1.1	-0.8	0.6	1.1	1.1	1.6	1.2
Medication: Atorvastatin	0.8	1.0	4.6	-0.9	-0.7	1.6	-0.4	-0.4	1.3	0.1	0.4	-0.4	0.2	-2.1	-1.4
Irritability	0.8	1.3	7.2	0.3	1.1	-2.7	1.2	-0.1	0.6	0.8	-1.2	-0.7	-1.3	-0.0	1.2
Myopia	0.8	1.1	5.3	0.8	-1.5	0.9	1.0	0.2	-2.3	-0.6	0.4	-0.0	-0.2	-1.1	-1.3
Bipolar Disorder (2018)	0.7	1.2	4.6	-1.2	-1.0	-2.1	-0.5	-1.1	0.2	-0.9	1.1	0.6	0.6	-1.2	-1.0
Worry (Nagel 2018)	0.7	1.5	6.0	0.4	1.0	-2.4	1.6	0.2	0.7	1.4	-1.1	-1.0	-1.4	0.9	0.9
LDL Cholesterol	0.7	1.1	4.1	-1.1	-1.8	2.0	-0.8	-0.8	0.6	-0.0	0.1	0.7	0.7	1.2	0.8
Hand grip strength (left)	0.7	1.8	7.1	-1.9	-1.1	-2.7	-1.1	-1.9	0.6	-0.1	1.0	1.1	1.1	-0.6	-0.4
Frequency of depressed mood in last 2 weeks	0.7	1.0	4.3	0.6	0.3	-2.1	-0.0	-0.5	-1.3	-1.6	1.2	0.9	0.5	-0.8	-0.4
Hearing difficulty/problems: Yes	0.7	1.1	3.4	0.2	0.3	-1.5	0.1	-0.9	-1.9	-1.0	1.1	1.1	0.7	-1.4	-0.9
High blood pressure	0.7	2.0	8.3	-0.3	1.4	2.9	-0.6	0.6	0.3	0.7	-1.1	-0.5	-0.6	2.1	2.5
Impedance of leg (left)	0.7	3.6	10.7	-0.5	-2.3	-3.3	-0.2	-0.9	0.4	-1.9	2.5	2.9	2.5	-0.7	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	4.0	0.4	0.2	0.8	0.7	0.7	0.1	2.0	-1.6	-1.8	-1.6	1.7	1.7
Heart attack	0.7	0.9	2.7	0.7	-0.3	-0.9	-1.1	-0.8	-1.0	-1.6	1.4	1.0	1.0	-0.3	-0.2
Trunk fat-free mass	0.7	3.8	7.2	0.9	2.3	1.3	0.9	1.5	1.7	2.3	-2.5	-2.4	-2.3	1.4	2.7
Medication: Cholesterol lowering	0.7	1.1	2.6	-1.6	-0.1	1.4	-1.0	-0.9	-0.8	-1.5	1.0	1.0	1.1	0.6	0.2
Arm fat mass (right)	0.7	2.9	9.3	0.1	1.9	3.0	0.2	1.5	0.6	1.4	-2.0	-2.5	-2.1	0.9	1.4
Trunk predicted mass	0.7	3.8	7.6	0.9	2.3	1.4	0.9	1.5	1.7	2.4	-2.5	-2.4	-2.3	1.4	2.8
Gout (self-reported)	0.7	0.9	3.5	-0.8	1.3	-1.9	0.8	-0.0	1.1	0.8	-0.8	-0.7	-0.4	0.6	1.1
Birth weight	0.7	1.4	2.9	1.2	-0.1	-0.3	1.7	0.9	0.4	1.5	-1.7	-1.4	-1.3	1.5	0.9
Number of full brothers	0.7	0.9	2.6	1.4	0.1	0.1	0.8	1.6	-1.2	0.7	-0.7	-0.8	-1.1	-0.8	0.1
Heart disease (mother)	0.7	0.8	2.3	0.5	0.7	1.3	1.4	0.8	1.5	0.5	-0.7	-0.9	-0.6	0.0	0.7
Hypertension (Self-reported)	0.7	1.9	8.2	-0.3	1.3	2.9	-0.3	0.6	0.1	0.8	-1.1	-0.6	-0.6	2.1	2.4
Qualifications: nursing, teaching	0.7	1.0	3.4	0.1	-0.3	1.4	1.8	-0.2	-0.4	0.9	-0.2	-1.1	-0.7	-1.4	-1.6
Medication: Aspirin	0.7	0.9	3.6	-1.9	-0.4	0.2	-1.0	-1.6	-0.9	-0.8	0.7	0.9	0.9	0.1	0.5
Illnesses of father: None of the above (group 1)	0.7	0.8	1.3	0.8	1.2	1.0	1.0	1.1	0.5	1.0	-0.9	-0.7	-0.6	0.9	1.1
Arm fat mass (left)	0.7	2.8	7.2	0.1	2.1	2.7	0.4	1.4	0.7	1.4	-2.0	-2.5	-2.1	0.8	1.5
Financial situation satisfaction	0.7	0.8	3.0	-0.3	0.9	0.3	0.9	0.7	1.1	0.9	-0.7	-0.3	-0.4	1.4	1.7
Number of operations (self-reported)	0.7	1.0	5.9	0.7	1.1	-0.9	-1.1	0.7	-2.4	0.5	-0.8	-0.6	-0.8	-0.3	-0.3
Age started oral contraceptive pill	0.7	0.9	1.5	1.1	0.3	1.0	1.1	1.2	0.8	0.8	-0.9	-1.1	-1.0	1.2	0.1
Supplements: Calcium	0.7	0.7	3.9	0.4	2.0	-0.5	0.7	-0.0	-1.4	0.8	-0.8	-0.5	-0.6	-0.1	0.4
Heart disease (siblings)	0.7	0.9	3.3	-1.8	-0.3	1.6	-0.7	-1.3	-0.5	-0.5	0.5	0.5	0.5	-1.2	0.4
Arm predicted mass (left)	0.7	3.3	6.8	0.7	2.2	1.7	0.8	1.5	1.4	2.0	-2.3	-2.6	-2.3	0.9	2.1
Depressed Affect (Nagel 2018)	0.6	1.3	13.0	-0.5	0.4	-3.6	0.3	-0.8	-1.0	-0.2	0.2	0.2	-0.4	-0.7	-0.2
Schizophrenia (2018)	0.6	1.3	3.9	-1.0	-2.0	0.4	-1.1	-1.3	0.2	-1.2	1.1	0.8	0.9	-1.0	-1.6
Ulcerative Colitis (UC)	0.6	1.1	5.2	0.4	-0.6	2.3	1.2	1.4	0.7	1.2	-0.7	-0.7	-0.7	-0.3	0.3
Major Depression (MDD)	0.6	0.7	2.2	1.5	0.6	-0.8	0.7	1.2	0.8	0.7	-0.5	-0.5	-0.6	-0.3	-1.1
HDL Cholesterol	0.6	1.0	3.2	0.0	-0.8	-1.5	-1.8	-0.2	0.3	-1.0	1.4	1.0	1.2	-0.7	-0.6
Heel T-Score	0.6	5.1	10.6	1.6	2.1	0.6	2.1	1.5	-0.7	2.0	-2.7	-2.9	-2.5	3.3	3.2
Ever had hysterectomy (womb removed)	0.6	0.6	1.9	0.3	0.5	0.5	-0.5	0.6	-1.4	0.6	-0.5	-0.7	-0.5	-1.3	-1.2
Medication: Metformin	0.6	0.8	2.4	-1.3	0.0	1.5	0.1	0.6	1.4	0.9	-0.7	-0.8	-0.4	0.7	0.4
Diabetes (mother)	0.6	0.8	3.4	-0.4	1.5	1.8	0.2	0.6	-0.4	0.4	-0.6	-0.8	-0.5	-1.1	0.5
Fed-up feelings	0.6	1.0	6.4	0.4	1.0	-2.5	1.1	0.2	-1.1	-0.1	-0.4	-0.5	-0.9	-1.0	-0.3
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	3.1	0.9	0.3	1.1	0.2	1.8	0.2	0.6	-0.9	-1.0	-0.9	0.5	0.4
Serious illness, injury or assault to yourself	0.6	0.7	3.0	0.9	-1.1	1.7	-0.5	1.3	-0.2	-0.5	0.4	0.3	0.2	0.6	-0.3
Sitting height	0.6	4.4	7.3	0.9	2.2	-1.0	2.0	1.9	2.5	2.5	-2.3	-1.9	-2.3	2.1	2.7
High blood pressure (mother)	0.6	0.9	4.6	-0.3	1.5	2.2	0.2	0.0	-1.5	0.3	-0.6	-0.7	-0.5	0.2	0.5
Body mass index (BMI)	0.6	2.4	8.6	-0.1	1.8	2.9	-0.4	1.1	0.1	1.0	-1.8	-2.5	-2.0	0.5	0.9
Hair/balding pattern: Pattern 2	0.6	0.8	2.7	1.3	0.4	-0.2	0.2	1.1	-1.6	0.0	-0.6	-0.6	-0.8	-1.1	-1.2
Arm fat percentage (right)	0.6	2.3	6.9	0.0	1.6	2.6	0.2	1.4	0.5	1.2	-1.9	-2.3	-2.0	0.8	1.0
Father’s age at death	0.6	0.8	1.8	1.3	0.7	0.8	0.2	0.6	-0.4	0.9	-1.3	-1.2	-1.1	0.8	-0.2
Medication: Lansoprazole	0.6	0.7	2.6	1.1	0.5	1.6	-0.1	1.1	-0.0	0.7	-0.9	-0.9	-0.8	-0.6	-0.1
Headache pain in last month	0.6	1.1	5.2	1.2	0.3	-2.3	-0.7	0.0	-0.4	0.2	-0.0	0.0	-0.3	-1.6	-1.7
Medication: Amlodipine	0.6	0.9	4.5	0.3	-0.6	2.1	0.1	-0.1	0.1	-1.0	0.5	0.8	0.7	1.4	1.0
Comparative body size at age 10	0.6	1.6	6.0	-1.2	0.7	-0.0	-2.4	-2.2	-0.8	-1.7	0.9	0.8	1.3	-0.4	-0.3
Medication for pain relief, constipation, heartburn	0.6	1.1	4.0	-0.9	-0.2	-0.2	-0.4	-0.9	0.9	-0.3	0.6	1.2	1.2	2.0	1.8
Whole body fat mass	0.6	2.6	5.7	-0.1	1.8	2.4	0.6	1.3	1.3	1.4	-2.0	-2.4	-2.0	1.0	1.6
Arm predicted mass (right)	0.6	3.2	6.4	0.8	2.2	1.4	1.0	1.5	1.6	2.0	-2.3	-2.5	-2.3	0.8	2.0
Alcohol intake frequency.	0.6	1.3	7.2	1.3	0.9	-2.7	0.3	0.9	0.3	0.8	-0.6	-0.9	-1.2	-1.1	-0.3
Number of full sisters	0.6	0.7	2.7	0.9	1.0	1.6	-0.4	0.7	-1.6	-0.5	-0.3	-0.4	-0.4	-0.5	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.1	0.2	1.5	0.8	0.2	0.1	-0.9	1.0	-1.3	-1.1	-1.0	0.2	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	3.2	-0.9	0.6	1.1	-0.1	0.3	-0.0	0.3	-0.4	0.0	-0.0	1.8	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	4.5	0.6	1.0	-1.2	0.2	0.0	-2.1	0.3	-0.3	-0.5	-0.4	0.2	0.2
Back pain experienced in last month	0.6	0.8	2.1	0.8	1.4	1.4	0.4	0.5	-0.3	0.5	-0.8	-1.2	-0.9	-0.8	-0.9
Miserableness	0.6	1.1	8.3	0.5	0.4	-2.9	0.5	-0.5	-1.6	-0.4	-0.0	0.2	-0.6	0.2	0.6
Pain type(s) experienced in last month: Hip pain	0.6	0.7	4.5	0.9	0.6	2.1	0.7	0.9	-0.2	0.5	-0.4	-0.4	-0.4	-0.8	0.2
Medication: Bendroflumethiazide	0.6	0.9	3.3	-0.3	0.4	1.8	0.5	0.7	1.3	0.9	-0.9	-0.5	-0.5	1.2	1.2
Alcohol drinker status: Never	0.6	0.7	1.8	1.4	0.4	-1.3	0.6	0.9	1.3	0.2	-0.0	0.1	-0.2	1.0	1.2
Arm fat-free mass (left)	0.6	3.0	6.1	0.9	2.2	1.7	0.5	1.5	1.2	1.9	-2.1	-2.5	-2.2	0.8	1.9
Leg fat mass (left)	0.6	2.4	5.5	-0.3	1.5	2.2	0.3	1.3	1.4	1.3	-1.9	-2.4	-2.0	1.1	1.4
Lupus	0.5	0.7	5.6	-1.2	0.6	0.5	-0.6	0.1	-2.4	-0.1	-0.2	-0.2	-0.2	-0.2	-0.5
Blood Platelet Count	0.5	6.1	43.4	-0.6	-1.0	6.6	-1.2	-0.2	-1.5	-1.1	0.6	-0.2	0.8	-3.2	-3.5
Cardiovascular Disease	0.5	1.6	10.6	-0.2	0.7	3.2	-0.3	1.2	0.7	0.6	-0.8	-0.5	-0.4	1.1	1.7
Neuroticism	0.5	1.3	14.1	0.4	0.2	-3.8	0.8	-0.0	-0.2	0.1	-0.1	0.0	-0.6	-0.1	0.0
Ever used hormone-replacement therapy (HRT)	0.5	0.6	5.7	0.2	-0.1	2.4	0.1	0.8	-0.4	0.2	-0.3	-0.4	-0.2	0.6	0.5
Supplements: Zinc	0.5	0.5	2.5	-0.3	0.1	0.0	1.6	1.1	0.7	1.0	-0.5	-0.6	-0.6	-0.5	0.0
Medication: Co-codamol	0.5	0.5	1.6	0.6	-0.7	0.4	-0.7	0.1	-1.3	-0.8	0.7	0.6	0.5	-1.0	-0.8
Severe depression (siblings)	0.5	0.6	3.0	1.5	-0.1	-1.7	-0.6	0.7	-0.5	-0.5	0.4	0.5	0.2	0.0	-0.4
Hand grip strength (right)	0.5	1.4	5.6	-1.3	-0.9	-2.4	-1.2	-1.4	1.1	-0.3	0.9	1.0	1.1	0.4	0.9
Taking other prescription medications	0.5	0.8	2.1	0.0	1.3	0.3	0.6	0.4	-0.9	1.3	-1.4	-1.0	-1.1	-0.4	-0.9
Trunk fat mass	0.5	2.3	4.8	-0.1	1.8	2.0	0.6	1.2	1.4	1.2	-1.8	-2.2	-1.9	1.0	1.6
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.7	1.6	-0.4	-1.6	1.2	0.7	0.8	0.1	-0.2	-0.7	-0.9	0.4	0.3
Medication: Simvastatin	0.5	0.7	3.8	-0.7	0.7	0.9	-1.0	-0.5	-1.9	-0.7	0.2	0.5	0.3	0.9	0.4
Illnesses of siblings	0.5	0.7	2.0	1.2	-0.5	-1.4	-0.5	0.3	1.1	-0.8	0.8	0.9	0.9	0.6	0.3
Qualifications: A levels/AS levels or equivalent	0.5	1.1	4.1	0.5	-0.0	2.0	1.8	0.2	1.1	1.4	-0.5	-0.5	-0.3	-0.9	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	7.5	0.5	0.2	-2.7	-0.0	-0.2	0.5	-0.1	0.2	-0.0	-0.2	-0.6	-0.1
Hair/balding pattern: Pattern 4	0.5	1.2	4.0	-0.3	-1.7	-0.5	-0.6	-0.3	-0.3	-0.7	1.2	0.7	0.6	-2.0	-1.9
Glaucoma (self-reported)	0.5	0.5	2.7	-0.6	-1.2	0.8	-0.9	0.3	1.6	0.1	0.2	0.4	0.4	0.1	-0.2
Arm fat-free mass (right)	0.5	2.6	5.1	0.6	2.1	1.4	0.7	1.2	1.3	1.8	-2.0	-2.3	-2.0	0.7	2.0
Neck or shoulder pain in last month	0.5	0.8	6.4	0.5	-0.1	2.5	0.2	0.5	-1.4	-0.4	0.1	0.2	0.2	-0.3	-0.3
Medication: Blood pressure	0.5	0.8	3.8	-0.5	0.1	1.5	-0.3	0.6	-0.1	-0.1	-0.2	-0.0	-0.2	1.7	2.0
Medication: Allopurinol	0.5	0.6	2.6	-0.3	0.4	-1.1	0.1	0.7	1.6	0.2	-0.4	-0.1	-0.0	1.1	1.1
Leg fat mass (right)	0.5	2.1	4.5	-0.4	1.5	2.1	-0.1	1.2	1.2	1.1	-1.7	-2.1	-1.7	1.1	1.5
Illnesses of siblings: Diabetes	0.5	0.6	2.5	-0.9	0.8	-1.6	1.3	-0.8	0.1	0.5	-0.4	-0.6	-0.7	-0.4	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	6.8	-0.1	0.5	-0.5	0.3	0.6	2.6	1.0	-0.7	-0.4	-0.5	1.1	1.1
Arm fat percentage (left)	0.5	2.2	7.3	-0.1	1.6	2.7	0.3	1.4	0.7	1.1	-1.7	-2.2	-1.8	0.7	1.0
Ever had bowel cancer screening	0.5	0.5	2.2	-0.2	-0.3	1.5	-0.7	-0.5	-1.2	-0.5	0.3	0.5	0.6	-0.5	-0.9
Eye problems/disorders: Cataract	0.5	0.6	2.2	1.0	1.5	-0.0	0.4	0.9	0.4	0.6	-0.8	-0.5	-0.7	0.7	0.6
Pain experienced in last month	0.5	0.8	2.6	-1.1	-0.6	-1.3	-0.4	-1.1	-0.5	-0.3	0.6	0.9	0.9	1.6	0.6
Basal cell carcinoma (self-reported)	0.5	0.6	2.3	0.1	-1.1	1.1	1.5	0.1	1.5	0.3	-0.1	-0.3	-0.2	-0.1	0.2
Impedance of whole body	0.5	2.4	7.8	-0.6	-1.7	-2.8	0.5	-0.8	0.4	-1.4	1.9	2.5	2.0	-0.3	-0.8
Fasting Glucose	0.4	0.4	1.7	0.6	0.6	0.9	0.7	0.6	0.3	0.4	-0.1	-0.1	-0.1	0.9	1.3
Rheumatoid Arthritis	0.4	0.5	5.0	-0.4	-0.3	2.2	-0.3	-0.1	0.7	-0.4	0.4	0.1	0.4	-0.0	-0.0
Ulcerative Colitis	0.4	0.7	4.5	0.2	-0.1	2.1	0.7	1.0	-0.3	0.9	-0.4	-0.5	-0.3	-0.6	0.3
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.5	0.6	-1.2	-1.0	0.2	1.2	0.8	0.4	-0.2	-0.2	-0.4	0.1	-0.6
Current tobacco smoking	0.4	0.6	1.3	-1.1	-1.0	-1.2	-0.5	-0.7	-0.8	-0.7	0.5	0.6	0.3	1.0	0.7
Waist circumference	0.4	1.6	5.6	-0.2	1.4	1.6	0.1	0.9	0.3	1.1	-1.6	-2.4	-2.1	-0.3	-0.2
Had menopause	0.4	0.5	3.6	-0.4	0.1	0.3	-1.0	-0.1	-1.9	-0.2	-0.0	-0.1	-0.1	-0.7	-0.9
Allergy	0.4	0.9	2.1	-1.1	-1.0	1.4	-0.9	-0.6	-0.8	-1.3	0.7	0.9	1.1	0.2	0.4
Fluid intelligence score	0.4	0.9	4.9	0.1	-0.2	1.2	1.0	0.2	2.2	1.0	-0.8	-0.6	-0.4	0.4	0.7
Time employed in main current job	0.4	0.5	1.5	-0.9	0.2	1.2	-0.5	-0.1	0.9	0.0	-0.4	-0.2	0.1	1.1	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	2.2	1.4	0.4	-0.4	0.5	1.5	-0.2	0.1	-0.4	-0.7	-0.8	-1.1	-0.8
Pulse rate	0.4	0.7	2.5	-0.6	0.1	0.7	0.6	0.5	1.1	0.7	-0.8	-0.2	-0.2	1.6	1.5
Pulse wave Arterial Stiffness index	0.4	0.5	1.8	0.5	1.0	-0.3	1.3	-0.0	-0.2	0.7	-0.5	-0.8	-0.7	-0.6	-0.3
Standing height	0.4	4.1	8.0	1.1	1.5	-1.4	2.8	1.1	2.7	2.6	-2.1	-1.6	-2.0	1.5	2.5
Birth weight of first child	0.4	0.7	3.1	0.4	-1.0	1.7	0.3	0.6	0.2	-0.4	0.6	0.6	0.6	-0.9	-1.2
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.8	0.1	-1.0	-0.9	-1.4	0.3	-0.7	-0.4	0.5	0.6	0.4	0.4	0.4
Blood clot in the leg (DVT)	0.4	0.5	2.3	-0.3	-1.1	-0.7	0.5	-0.2	-0.2	-0.0	0.3	0.1	-0.2	-1.5	-1.3
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	3.2	0.7	-0.3	-0.8	-0.5	-0.4	-0.3	0.2	0.1	0.0	0.1	-1.8	-1.5
Body fat percentage	0.4	1.4	3.6	-0.4	1.3	1.9	0.2	1.1	1.0	0.7	-1.3	-1.8	-1.5	0.7	0.9
Exposure to tobacco smoke outside home	0.4	0.5	1.0	-0.7	-0.9	-1.0	0.2	-0.4	-0.3	-0.7	0.9	0.8	0.4	-0.9	-0.4
Pulse wave peak to peak time	0.4	0.5	1.6	-0.6	-1.0	0.3	-1.3	-0.2	0.2	-0.8	0.6	0.8	0.7	0.5	0.2
Health satisfaction	0.4	0.5	2.0	0.6	1.0	1.4	-0.4	1.3	0.4	0.2	-0.2	-0.0	-0.1	-0.4	0.3
Angina (self-reported)	0.4	0.5	1.5	0.3	-1.2	0.3	-0.5	-0.2	-0.7	-1.2	0.9	0.8	0.8	-0.5	-0.2
Migraine (self-reported)	0.4	0.5	2.1	0.9	0.8	0.1	0.1	1.5	0.8	0.9	-0.7	-0.5	-0.6	0.1	0.6
Leg pain on walking	0.4	0.6	1.8	-1.1	0.8	1.2	-1.4	0.3	-0.4	-0.2	-0.1	0.0	0.3	0.2	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.6	0.6	0.9	0.5	0.5	1.0	0.2	0.5	-0.5	-0.5	-0.6	0.6	1.2
Medication: Aspirin	0.4	0.5	1.7	-1.3	-0.2	0.5	-0.8	-0.9	-0.9	-0.6	0.5	0.6	0.6	0.1	0.2
Commuting to job workplace: Walk	0.4	0.5	1.7	-0.1	-0.6	-1.3	1.2	-0.9	-0.6	0.6	-0.1	-0.2	-0.6	-0.4	-0.2
Osteoporosis (self-reported)	0.4	0.4	1.4	-0.6	-0.2	0.6	0.5	-0.6	0.2	-0.5	0.6	0.6	0.6	-1.0	-1.2
Osteoarthritis (self-reported)	0.4	0.5	1.6	0.8	0.5	1.3	0.9	0.9	0.4	0.5	-0.8	-0.8	-0.5	0.7	0.4
Medication: Gliclazide	0.4	0.4	1.3	-1.0	-0.4	1.0	0.3	0.1	1.2	0.7	-0.3	-0.8	-0.5	0.0	-0.1
Smoking status: Current	0.4	0.7	1.5	-1.2	-1.1	-1.2	-0.5	-0.7	-0.4	-0.9	0.6	0.8	0.5	0.8	0.5
Number of self-reported non-cancer illnesses	0.4	0.8	5.8	-0.3	0.6	2.4	-0.7	0.2	-0.5	-0.7	0.3	0.6	0.5	-0.9	-0.1
Vascular/heart problems diagnosed by doctor	0.4	1.2	5.3	0.1	-1.2	-2.3	0.7	-0.4	-0.1	-0.3	0.8	0.3	0.4	-1.4	-1.9
Alzheimer’s Disease (in mother)	0.3	0.4	3.0	0.1	0.2	-1.7	0.1	0.0	0.6	-0.0	-0.1	-0.1	-0.4	-0.9	-0.2
Verbal and Numeric Reasoning (VNR)	0.3	0.7	3.7	-1.2	0.1	1.9	0.7	-1.0	0.2	0.5	-0.4	-0.1	0.1	0.7	1.0
Height	0.3	6.6	13.7	1.0	1.6	-2.2	3.7	1.1	1.7	3.5	-3.4	-2.8	-3.3	2.2	2.3
Waist Hip Ratio (WHR)	0.3	1.4	6.3	0.0	-0.4	-2.5	0.2	-0.6	-0.8	-0.2	0.6	0.4	-0.0	-1.9	-2.2
Lung FEV1/FVC ratio	0.3	1.3	3.6	-1.1	-0.0	-0.6	-1.8	-1.9	-1.7	-0.9	0.4	-0.1	0.1	-1.4	-1.2
Chronotype (morning person)	0.3	0.6	3.1	1.8	0.3	-1.5	-0.1	0.3	0.7	-0.6	0.7	-0.1	-0.0	-0.4	-0.4
Sensitivity / hurt feelings	0.3	0.5	2.6	-0.1	0.4	-1.6	0.9	-0.2	0.5	0.4	-0.4	-0.2	-0.5	0.5	1.1
Angina	0.3	0.3	1.0	0.4	-1.0	0.0	-0.6	-0.1	-0.4	-1.0	0.7	0.6	0.6	-0.5	-0.2
Medication for hormone replacement therapy	0.3	0.4	1.5	-0.5	-0.5	0.7	0.3	1.2	0.5	0.6	-0.3	-0.4	-0.3	0.8	0.5
Diabetes (father)	0.3	0.3	1.3	0.3	0.7	-0.1	1.1	-0.4	-0.2	0.5	-0.8	-0.5	-0.5	-0.1	-0.6
Trunk fat percentage	0.3	1.2	3.0	-0.4	1.4	1.7	0.3	0.9	0.9	0.6	-1.2	-1.7	-1.4	0.7	1.0
Medication: Levothyroxine sodium	0.3	0.5	1.5	-0.6	-0.2	-0.7	-1.1	0.3	1.0	0.0	-0.1	0.5	0.3	1.2	0.6
Chronic bronchitis/emphysema (father)	0.3	0.4	1.3	-0.9	0.1	-0.3	-0.7	0.3	-1.1	0.8	-0.6	-0.5	-0.4	0.6	0.3
Hearing difficulty/problems with background noise	0.3	0.5	3.5	0.1	0.6	-1.0	1.1	-0.3	-1.9	-0.0	-0.1	0.0	-0.3	-0.3	-0.4
Financial difficulties in last 2 years	0.3	0.4	1.2	-0.2	1.1	-0.8	0.8	0.1	1.0	0.8	-0.5	-0.2	-0.5	0.4	0.3
Worrier / anxious feelings	0.3	0.6	1.7	-0.3	1.2	-1.3	0.6	-0.4	-0.6	-0.1	-0.0	0.5	0.2	1.1	1.1
Prospective memory result	0.3	0.4	1.1	0.9	-0.4	0.0	-1.1	0.7	-0.5	-0.7	0.2	-0.3	-0.1	-1.1	-0.9
Tense / ‘highly strung’	0.3	0.6	3.0	0.3	-0.3	-1.7	1.1	0.3	0.4	0.7	-0.5	-0.8	-0.9	-0.1	-0.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	3.2	-0.5	0.4	1.8	0.6	-0.8	-0.5	-0.0	0.5	0.8	0.9	-0.3	-0.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.8	0.1	0.2	-1.3	-0.2	0.8	0.4	0.8	-0.9	-0.3	-0.6	1.1	0.8
Medication: Ventolin 100micrograms inhaler	0.3	0.4	2.2	0.6	0.1	0.8	0.8	0.6	-1.5	0.2	-0.1	-0.3	-0.2	-0.3	-0.7
Chest pain or discomfort	0.3	0.4	1.0	-0.4	-0.7	-0.7	-0.3	-0.5	-0.0	-1.0	0.9	0.6	0.4	-0.9	-0.3
Age at last live birth	0.3	0.4	2.6	0.2	0.5	-0.3	0.1	0.2	1.6	0.1	0.2	0.7	0.7	0.7	0.7
Family relationship satisfaction	0.3	0.3	1.8	0.7	-0.2	0.6	0.7	1.3	-0.4	0.3	-0.4	-0.1	-0.1	0.5	0.6
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.6	0.1	0.7	1.0	-0.1	1.2	-0.6	-0.1	-0.2	0.0	0.0	1.1	0.4
Knee pain experienced in last month	0.3	0.4	2.1	-0.5	-0.6	1.0	-0.1	-0.5	-0.4	-0.5	0.3	-0.1	-0.1	-1.5	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.6	0.7	0.3	-1.3	0.1	0.8	1.1	0.4	0.2	0.1	-0.1	-1.2	-0.5
Breast cancer (self-reported)	0.3	0.4	1.7	0.2	0.6	-0.1	-0.8	0.1	-0.1	0.6	-0.4	-0.2	-0.1	1.0	1.3
Commuting to job workplace: Public transport	0.3	0.4	1.1	-0.3	-0.6	-0.7	-0.8	-0.4	1.1	-0.5	0.5	0.7	0.6	0.2	-0.4
Medication: Lisinopril	0.3	0.4	1.6	0.1	0.5	1.3	-1.0	-0.4	0.3	-0.1	-0.5	-0.0	-0.1	0.5	1.1
Fractured/broken bones in last 5 years	0.3	0.3	1.3	0.5	-0.3	-1.1	0.2	0.6	0.9	0.2	-0.1	0.2	-0.1	1.0	-0.0
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.3	-0.3	-0.9	-0.3	0.7	-0.3	-0.5	0.2	0.1	-0.1	-0.4	-1.1	-1.1
Alzheimer’s Disease (in father)	0.2	0.2	0.8	0.3	-0.6	0.1	0.3	-0.1	-0.9	0.4	0.1	-0.0	-0.3	-0.7	-0.6
Alzheimer’s Disease (including proxy)	0.2	0.3	2.7	-0.2	-0.2	-1.6	-0.2	-0.6	0.1	-0.2	0.4	0.5	0.1	-0.6	-0.5
Smoking Status	0.2	0.5	2.0	-0.6	-0.8	-1.4	0.5	-0.0	0.3	0.3	-0.3	-0.0	-0.4	1.2	0.7
Hair Pigment	0.2	4.6	10.0	1.2	2.5	0.4	3.2	2.1	0.3	2.4	-2.7	-2.6	-2.7	0.0	2.4
Tanning	0.2	3.0	10.2	-0.4	-0.7	-0.6	-2.5	-1.4	-3.2	-1.7	1.7	1.6	1.6	-1.4	-1.7
Vitamin and mineral supplements	0.2	0.3	1.0	0.1	-0.2	0.7	0.1	0.0	-0.3	0.6	-0.8	-1.0	-0.8	-0.2	-0.1
Age when periods started (menarche)	0.2	0.4	0.8	0.2	-0.8	0.8	0.3	-0.3	-0.7	-0.5	0.6	0.7	0.5	-0.9	-0.5
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	2.5	-0.2	0.1	0.0	-0.7	-0.4	-1.6	0.2	-0.2	0.0	-0.1	0.1	0.4
Impedance of arm (right)	0.2	0.7	2.7	-0.1	-1.0	-1.6	1.0	-0.1	0.4	-0.3	0.7	1.4	0.9	0.4	-0.0
Happiness	0.2	0.2	0.8	-0.3	0.7	-0.9	0.3	0.2	-0.4	0.2	-0.6	-0.2	-0.3	0.3	0.1
Impedance of arm (left)	0.2	0.9	3.1	-0.3	-1.0	-1.8	1.0	-0.5	0.2	-0.6	1.0	1.6	1.1	-0.1	-0.4
Length of working week for main job	0.2	0.2	0.5	0.0	-0.1	0.7	0.6	0.6	0.4	0.6	-0.4	-0.4	-0.4	-0.1	0.0
Leg fat percentage (right)	0.2	0.6	3.2	-0.9	0.2	1.8	-1.3	0.4	0.7	-0.4	-0.1	-0.5	-0.2	0.4	0.5
Wheeze or whistling in the chest in last year	0.2	0.4	2.7	0.6	0.7	0.8	0.4	0.8	-1.6	-0.5	0.3	0.1	-0.0	-0.3	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.9	0.5	0.9	-0.1	0.6	-0.9	-0.5	0.4	-0.5	-0.5	-0.2	0.3	0.5
Shortness of breath walking on level ground	0.2	0.3	1.0	-0.6	0.5	0.5	-0.7	-0.2	-0.6	-0.3	0.2	0.3	0.5	1.0	0.4
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.7	0.2	0.6	0.2	0.1	0.4	-0.3	0.4	-0.2	-0.0	-0.4	0.8	0.7
Medication for cholesterol	0.2	0.3	2.1	0.7	-0.2	-1.5	0.9	-0.2	-0.2	0.2	-0.3	-0.5	-0.5	0.3	-0.1
Medication: Blood pressure	0.2	0.5	1.4	-0.3	1.1	0.5	0.0	0.2	1.0	0.7	-0.7	-0.2	-0.3	0.6	1.2
Leg fat percentage (left)	0.2	0.6	3.5	-0.7	0.3	1.9	-0.8	0.6	0.7	-0.0	-0.5	-1.1	-0.7	0.4	0.2
Blood White Count	0.1	0.8	4.8	0.6	0.4	-1.5	-0.2	-0.3	-2.2	-0.4	-0.2	-0.5	-0.5	-0.6	-1.0
Hypothyroidism (self reported)	0.1	0.2	0.9	-0.3	-0.3	-0.8	-0.9	0.3	-0.9	0.2	-0.2	0.0	-0.2	0.1	-0.2
Respiratory disease	0.1	0.3	1.3	1.1	0.4	-0.4	0.4	0.9	0.3	0.3	-0.4	-0.5	-0.6	0.3	0.4
Number of treatments/medications taken	0.1	0.1	0.6	-0.3	-0.1	0.8	-0.2	0.2	-0.3	0.2	0.0	0.2	0.2	-0.1	-0.4
Past tobacco smoking	0.1	0.2	0.6	0.6	0.5	0.8	-0.6	0.2	0.0	-0.4	0.0	-0.1	0.2	0.2	0.2
Asthma	0.1	0.2	0.5	-0.2	-0.6	-0.7	-0.3	-0.1	-0.5	-0.2	0.6	0.4	0.3	-0.2	-0.5
Illnesses of mother	0.1	0.2	0.5	0.1	-0.7	-0.7	-0.2	0.1	-0.1	0.3	0.1	0.3	0.2	-0.4	-0.6
Peak expiratory flow (PEF)	0.1	0.3	1.4	-0.7	-0.2	-0.6	-0.6	-0.1	0.5	0.1	0.5	0.2	-0.1	-1.2	0.0
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.7	-0.7	-0.9	0.4	0.0	-0.1	0.4	0.1	-0.1	0.1	0.2	-0.4	-0.3
Smoking status: Previous	0.1	0.2	0.6	-0.3	-0.7	-0.8	0.4	-0.2	-0.1	0.3	0.2	0.3	0.1	-0.6	-0.5
Asthma (self-reported)	0.1	0.1	0.4	-0.0	-0.5	-0.5	-0.1	0.2	-0.4	-0.1	0.5	0.3	0.2	-0.3	-0.6
Ever smoked	0.1	0.2	0.8	-0.4	-0.2	-0.9	0.2	-0.4	-0.8	0.4	-0.1	0.1	-0.2	0.2	0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0

Hub : Genes

HIP1

Models

Trait associations