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chr7:115,255,384-117,259,946

Best TWAS P=4.48e-53 · Best GWAS P=1.11e-53 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
4	GTEx	Artery Tibial	CAPZA2	0.11	0.08	lasso	4	0.08	1.3e-06	-15.3	15.3	6.8e-53	-0.97	0.01	0.99	TRUE
13	ROSMAP	Brain Pre-frontal Cortex	CAV2	0.08	0.02	enet	16	0.04	3.6e-06	-4.3	-6.6	4.2e-11	0.14	0.43	0.03	TRUE
7	GTEx	Breast Mammary Tissue	CAPZA2	0.12	0.05	lasso	1	0.03	7.1e-03	-15.3	15.3	4.5e-53	-0.97	0.01	0.93	FALSE
17	The Cancer Genome Atlas	Prostate Adenocarcinoma	CAPZA2	0.05	0.05	lasso	2	0.04	2.2e-05	-15.3	15.3	6.1e-53	-0.97	0.00	0.99	FALSE
12	METSIM	Adipose	CAPZA2	0.05	0.04	lasso	7	0.02	1.2e-04	-14.6	14.6	2.4e-48	-0.95	0.02	0.98	FALSE
10	GTEx	Esophagus Muscularis	CAPZA2	0.20	0.12	enet	19	0.15	2.3e-09	-15.3	14.4	9.1e-47	-0.93	0.01	0.99	FALSE
8	GTEx	Breast Mammary Tissue (Male)	CAPZA2	0.14	0.00	lasso	4	0.06	1.4e-02	-15.3	13.1	2.1e-39	-0.83	0.02	0.62	FALSE
16	The Cancer Genome Atlas	Lung Adenocarcinoma	CAPZA2	0.03	0.03	lasso	1	0.02	6.8e-04	-12.7	12.7	6.4e-37	-0.79	0.04	0.70	FALSE
18	The Cancer Genome Atlas	Thyroid Carcinoma	CAPZA2	0.04	0.00	blup	62	0.01	5.3e-02	-15.4	11.1	9.9e-29	-0.84	0.01	0.80	FALSE
11	GTEx	Nerve Tibial	CAPZA2	0.09	0.04	lasso	3	0.06	5.4e-05	-12.0	9.4	6.2e-21	-0.71	0.09	0.87	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CAPZA2	0.04	0.00	blup	367	0.01	6.1e-02	-9.1	9.1	1.0e-19	-0.64	0.07	0.65	FALSE
9	GTEx	Esophagus Mucosa	CAPZA2	0.15	0.02	enet	67	0.10	4.8e-07	-15.3	9.0	1.6e-19	-0.52	0.01	0.96	FALSE
14	YFS	Blood	CAPZA2	0.12	0.05	bslmm	365	0.09	7.5e-28	-14.5	8.6	5.8e-18	-0.59	0.01	0.99	FALSE
20	The Cancer Genome Atlas	Thyroid Carcinoma	ST7OT4	0.06	0.02	enet	5	0.04	7.0e-05	-7.4	6.7	2.8e-11	-0.24	0.02	0.04	FALSE
2	CommonMind	Brain Pre-frontal Cortex	CAV2	0.10	0.01	blup	428	0.09	1.3e-11	6.6	-6.4	1.5e-10	0.08	0.72	0.01	FALSE
5	GTEx	Brain Caudate basal ganglia	MET	0.39	0.35	enet	25	0.30	2.1e-09	6.2	-6.4	1.6e-10	0.20	1.00	0.00	FALSE
19	The Cancer Genome Atlas	Thyroid Carcinoma	MET	0.05	0.07	lasso	3	0.07	4.4e-07	6.2	6.4	1.6e-10	-0.31	0.49	0.36	FALSE
3	CommonMind	Brain Pre-frontal Cortex	MET	0.08	0.07	lasso	4	0.07	4.5e-09	6.2	-6.4	2.0e-10	0.20	1.00	0.00	FALSE
6	GTEx	Brain Putamen basal ganglia	MET	0.21	0.12	lasso	1	0.05	2.0e-02	6.3	-6.3	3.6e-10	0.20	0.22	0.04	FALSE
15	The Cancer Genome Atlas	Brain Lower Grade Glioma	MET	0.06	0.08	enet	18	0.08	3.3e-09	6.2	-5.5	2.9e-08	0.18	1.00	0.00	FALSE