Best TWAS P=4.48e-53 · Best GWAS P=1.11e-53 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CAPZA2 | 0.04 | 0.00 | blup | 367 | 0.01 | 6.1e-02 | -9.1 | 9.1 | 1.0e-19 | -0.64 | 0.07 | 0.65 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | CAV2 | 0.10 | 0.01 | blup | 428 | 0.09 | 1.3e-11 | 6.6 | -6.4 | 1.5e-10 | 0.08 | 0.72 | 0.01 | FALSE |
| 3 | CommonMind | Brain Pre-frontal Cortex | MET | 0.08 | 0.07 | lasso | 4 | 0.07 | 4.5e-09 | 6.2 | -6.4 | 2.0e-10 | 0.20 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Artery Tibial | CAPZA2 | 0.11 | 0.08 | lasso | 4 | 0.08 | 1.3e-06 | -15.3 | 15.3 | 6.8e-53 | -0.97 | 0.01 | 0.99 | TRUE |
| 5 | GTEx | Brain Caudate basal ganglia | MET | 0.39 | 0.35 | enet | 25 | 0.30 | 2.1e-09 | 6.2 | -6.4 | 1.6e-10 | 0.20 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Brain Putamen basal ganglia | MET | 0.21 | 0.12 | lasso | 1 | 0.05 | 2.0e-02 | 6.3 | -6.3 | 3.6e-10 | 0.20 | 0.22 | 0.04 | FALSE |
| 7 | GTEx | Breast Mammary Tissue | CAPZA2 | 0.12 | 0.05 | lasso | 1 | 0.03 | 7.1e-03 | -15.3 | 15.3 | 4.5e-53 | -0.97 | 0.01 | 0.93 | FALSE |
| 8 | GTEx | Breast Mammary Tissue (Male) | CAPZA2 | 0.14 | 0.00 | lasso | 4 | 0.06 | 1.4e-02 | -15.3 | 13.1 | 2.1e-39 | -0.83 | 0.02 | 0.62 | FALSE |
| 9 | GTEx | Esophagus Mucosa | CAPZA2 | 0.15 | 0.02 | enet | 67 | 0.10 | 4.8e-07 | -15.3 | 9.0 | 1.6e-19 | -0.52 | 0.01 | 0.96 | FALSE |
| 10 | GTEx | Esophagus Muscularis | CAPZA2 | 0.20 | 0.12 | enet | 19 | 0.15 | 2.3e-09 | -15.3 | 14.4 | 9.1e-47 | -0.93 | 0.01 | 0.99 | FALSE |
| 11 | GTEx | Nerve Tibial | CAPZA2 | 0.09 | 0.04 | lasso | 3 | 0.06 | 5.4e-05 | -12.0 | 9.4 | 6.2e-21 | -0.71 | 0.09 | 0.87 | FALSE |
| 12 | METSIM | Adipose | CAPZA2 | 0.05 | 0.04 | lasso | 7 | 0.02 | 1.2e-04 | -14.6 | 14.6 | 2.4e-48 | -0.95 | 0.02 | 0.98 | FALSE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | CAV2 | 0.08 | 0.02 | enet | 16 | 0.04 | 3.6e-06 | -4.3 | -6.6 | 4.2e-11 | 0.14 | 0.43 | 0.03 | TRUE |
| 14 | YFS | Blood | CAPZA2 | 0.12 | 0.05 | bslmm | 365 | 0.09 | 7.5e-28 | -14.5 | 8.6 | 5.8e-18 | -0.59 | 0.01 | 0.99 | FALSE |
| 15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MET | 0.06 | 0.08 | enet | 18 | 0.08 | 3.3e-09 | 6.2 | -5.5 | 2.9e-08 | 0.18 | 1.00 | 0.00 | FALSE |
| 16 | The Cancer Genome Atlas | Lung Adenocarcinoma | CAPZA2 | 0.03 | 0.03 | lasso | 1 | 0.02 | 6.8e-04 | -12.7 | 12.7 | 6.4e-37 | -0.79 | 0.04 | 0.70 | FALSE |
| 17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CAPZA2 | 0.05 | 0.05 | lasso | 2 | 0.04 | 2.2e-05 | -15.3 | 15.3 | 6.1e-53 | -0.97 | 0.00 | 0.99 | FALSE |
| 18 | The Cancer Genome Atlas | Thyroid Carcinoma | CAPZA2 | 0.04 | 0.00 | blup | 62 | 0.01 | 5.3e-02 | -15.4 | 11.1 | 9.9e-29 | -0.84 | 0.01 | 0.80 | FALSE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | MET | 0.05 | 0.07 | lasso | 3 | 0.07 | 4.4e-07 | 6.2 | 6.4 | 1.6e-10 | -0.31 | 0.49 | 0.36 | FALSE |
| 20 | The Cancer Genome Atlas | Thyroid Carcinoma | ST7OT4 | 0.06 | 0.02 | enet | 5 | 0.04 | 7.0e-05 | -7.4 | 6.7 | 2.8e-11 | -0.24 | 0.02 | 0.04 | FALSE |