Hub : Genes

CAV2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1030	0.0280	4.1e-08	0.015	0.095	0.071	0.094	0.062	5.4e-03	1.3e-11	5.7e-09	1.8e-11	4.6e-08
2	GTEx	Cells EBV-transformed lymphocytes	0.6510	0.0650	1.6e-10	0.520	NA	0.526	NA	0.500	1.3e-19	NA	6.6e-20	NA	1.2e-18
3	GTEx	Esophagus Mucosa	0.1470	0.0470	3.1e-04	0.042	NA	0.064	NA	0.051	7.9e-04	NA	4.6e-05	NA	2.4e-04
4	GTEx	Pancreas	0.4700	0.0700	2.3e-12	0.373	NA	0.408	NA	0.424	9.9e-17	NA	1.5e-18	NA	1.9e-19
5	GTEx	Testis	0.4610	0.0670	4.0e-13	0.442	NA	0.403	NA	0.427	1.7e-21	NA	3.3e-19	NA	1.4e-20
6	ROSMAP	Brain Pre-frontal Cortex	0.0813	0.0273	8.2e-05	0.016	0.041	0.042	0.041	0.029	2.9e-03	4.4e-06	3.6e-06	4.7e-06	1.1e-04
7	YFS	Blood	0.0495	0.0173	1.5e-05	0.006	0.015	0.017	0.016	0.019	4.4e-03	6.4e-06	1.9e-06	4.6e-06	4.0e-07
8	TCGA	Glioblastoma Multiforme	0.2470	0.1180	9.5e-03	-0.001	0.000	-0.006	NA	-0.010	3.3e-01	3.2e-01	5.3e-01	NA	9.5e-01
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.0947	0.0318	8.3e-08	0.100	0.068	0.065	NA	0.072	2.2e-11	4.3e-08	8.0e-08	NA	1.5e-08
10	TCGA	Kidney Renal Papillary Cell Carcinoma	0.2380	0.0740	1.7e-07	0.196	0.158	0.199	NA	0.206	2.0e-11	2.3e-09	1.4e-11	NA	5.9e-12
11	TCGA	Thyroid Carcinoma	0.0420	0.0220	5.2e-03	-0.002	0.014	0.000	NA	-0.002	6.8e-01	1.5e-02	3.2e-01	NA	5.1e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.5	0.8	4.5	1.1	0.1	0.6	-0.6	0.5	-0.4	-1.3	-0.6	-0.2	-0.3	-2.1
Bipolar Disorder or Schizophrenia	0.5	1.3	4.0	0.5	-0.3	-0.6	1.4	-1.4	0.2	-0.5	-2.0	1.6	1.4	-0.6
Depressed Affect (Nagel 2018)	1.0	2.1	5.9	0.1	2.4	0.9	-0.7	0.8	1.6	-1.3	0.4	-2.0	-2.0	-1.8
Depression (Nagel 2018)	0.9	1.4	4.8	1.3	2.2	0.3	1.3	-1.1	0.8	-0.3	-0.2	0.1	-0.2	-2.2
Intelligence (Savage-Jansen 2018)	0.4	1.3	6.0	-0.6	-0.7	0.2	0.4	-0.6	-1.3	-0.5	-2.5	0.9	0.6	-1.7
Neuroticism (Nagel 2018)	0.8	1.8	7.7	0.3	2.2	-0.8	1.4	-1.2	2.8	0.5	-1.6	0.2	0.1	-0.3
Schizophrenia (2018)	1.2	2.4	5.4	-0.2	-0.4	-1.3	2.3	-2.2	0.6	0.5	-2.1	2.1	2.1	0.9
Schizophrenia vs Biploar Disorder	0.9	1.2	4.3	-1.5	-0.5	-0.5	1.1	-1.0	-1.4	0.5	-2.1	0.9	0.7	0.4
Worry (Nagel 2018)	1.3	2.8	4.9	-2.0	0.6	-2.2	2.2	-2.0	1.2	1.1	-1.6	1.8	1.4	1.3
Alzheimer’s Disease (in mother)	0.2	0.2	0.7	0.8	-0.4	0.6	0.0	-0.0	0.3	0.9	-0.4	0.1	0.3	0.1
Alzheimer’s Disease (in father)	1.0	1.0	2.0	0.0	0.9	1.4	-1.3	1.4	0.7	-0.8	0.6	-1.4	-1.3	-0.1
Alzheimer’s Disease (including proxy)	0.3	0.5	1.5	0.6	0.2	0.6	-0.7	0.8	0.5	0.4	0.7	-1.2	-0.8	-0.5
Crohns Disease (2017)	0.2	0.4	1.5	-0.0	-0.8	1.0	-0.3	0.3	-1.0	-1.2	0.7	0.2	0.2	0.1
Irritable Bowel Disease (IBD)	0.3	0.8	2.9	-0.8	-1.0	1.4	-0.7	0.6	-1.7	-0.8	0.7	-0.0	0.1	0.1
Ulcerative Colitis (UC)	0.3	0.5	2.2	-0.7	-1.1	1.2	-0.5	0.4	-1.5	-0.0	0.4	0.1	0.3	0.1
Major Depression (MDD)	0.2	0.2	0.8	0.2	-0.4	0.0	-0.1	0.2	-0.4	0.6	-0.6	-0.3	-0.2	-0.9
Reaction Time	0.2	0.3	1.0	0.6	-1.0	0.6	0.1	0.1	0.2	1.0	0.2	0.3	0.7	0.5
Verbal and Numeric Reasoning (VNR)	0.3	0.8	3.2	-0.7	-0.5	0.0	0.6	-0.9	-0.4	-0.6	-1.8	1.1	0.9	-0.9
Breast Cancer	0.7	1.8	8.6	2.9	0.6	-0.9	0.9	-0.7	1.7	0.4	-0.3	0.2	0.4	-2.3
Ovarian Cancer	0.4	0.5	1.4	0.6	-0.3	-0.8	0.6	-0.6	0.5	-0.3	-1.0	0.8	0.7	-1.2
Prostate Cancer	0.9	1.2	3.8	-1.7	-0.5	0.9	-1.3	1.3	-1.9	0.4	-0.5	-1.0	-1.1	0.1
Age at First Birth	1.7	2.5	7.8	0.2	-1.0	-0.5	1.8	-2.1	1.2	-0.0	-1.1	2.6	2.8	-1.1
Bipolar Disorder (2011)	0.6	0.5	2.9	0.9	0.2	0.6	-0.6	0.6	-0.0	-0.6	-0.8	-0.3	-0.4	-1.7
Body Mass Index (BMI) (2010)	1.7	2.4	6.7	1.3	2.5	-0.9	-0.7	0.9	1.1	-1.0	0.1	-2.3	-2.6	-1.4
Coronary Artery Disease (CAD)	2.0	2.4	8.6	-1.8	-2.9	0.7	-0.8	0.6	-2.9	-1.5	-0.9	0.9	0.4	0.7
Crohns Disease (2012)	0.2	0.4	0.6	0.8	-0.4	0.3	0.5	-0.4	0.3	-0.6	0.7	0.8	0.8	0.8
Mean Putamen Volume	0.2	0.3	1.9	0.3	0.6	-0.4	0.2	-0.2	-0.1	-0.5	1.4	-0.4	-0.3	0.1
Fasting Glucose	0.3	0.3	0.9	-0.8	-0.1	-0.3	-0.6	0.4	-0.5	0.0	0.9	-0.3	-0.4	1.0
HbA1C	0.2	0.2	0.8	-0.0	-0.7	0.7	-0.3	0.1	-0.4	-0.2	-0.9	0.1	-0.0	-0.5
HDL Cholesterol	0.4	0.7	2.7	-0.1	0.5	1.6	-0.5	0.3	-1.3	0.5	-0.2	-0.2	-0.3	-1.6
LDL Cholesterol	0.8	1.3	7.2	2.7	0.9	-0.4	0.2	0.0	1.8	0.2	0.3	-0.7	-0.6	-1.3
Lupus	0.2	0.3	0.8	-0.5	-0.7	0.4	-0.5	0.5	-0.8	0.1	0.1	0.4	0.3	0.9
Neuroticism (2016)	0.7	1.1	3.4	-1.9	1.4	0.3	0.2	-0.0	0.3	-0.4	1.1	-1.6	-1.5	0.5
Primary Biliary Cirrhosis	0.5	0.7	3.5	-0.4	0.0	0.2	-0.9	0.7	-0.6	-1.9	-0.2	-0.5	-0.9	-0.9
Rheumatoid Arthritis	0.7	0.9	3.3	-0.2	1.8	-0.2	1.3	-1.4	0.2	-1.3	0.4	0.3	0.0	-1.0
Schizophrenia (2014)	0.4	1.0	3.6	-0.9	-0.9	-0.4	0.7	-0.6	-1.3	0.3	-1.9	0.9	0.7	1.0
Triglycerides	0.9	1.5	4.6	1.6	-0.1	-0.7	1.3	-1.2	2.1	0.9	-1.1	1.2	1.2	0.6
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.5	-1.2	1.0	0.5	-0.4	0.2	-1.2	-1.1	0.5	-0.6	-1.0	0.2
Ulcerative Colitis	0.4	0.6	1.6	-1.2	-0.0	0.9	-0.6	0.4	-1.3	-0.6	1.1	-0.3	-0.3	-0.1
Blood Eosinophil Count	0.1	0.7	4.2	-2.0	0.5	-1.0	0.1	-0.3	-1.2	-0.1	-0.3	-0.1	-0.5	-0.2
Blood Platelet Count	1.3	14.6	43.6	-6.4	0.2	0.3	-3.5	3.5	-6.6	-2.6	0.3	-3.7	-4.3	3.4
Blood Red Count	0.4	4.2	11.3	0.2	-1.3	-1.7	2.4	-2.4	0.4	1.0	-3.2	3.4	2.8	-0.1
Blood White Count	1.6	11.7	26.8	-3.1	-0.4	1.6	-4.4	4.5	-5.2	-3.0	1.5	-4.1	-4.3	1.7
Heel T-Score	0.2	1.8	5.5	-2.3	-1.0	-2.3	0.7	-0.6	-0.4	0.3	-1.2	0.7	0.7	2.2
BMI	0.6	3.5	10.0	0.2	-0.9	1.1	-3.1	3.2	-1.1	-0.9	2.2	-2.2	-2.2	0.6
Height	0.4	6.8	26.0	-0.5	1.6	-5.1	-1.1	1.7	0.6	-0.2	-4.0	-3.2	-3.9	-0.7
Waist Hip Ratio (WHR)	0.6	2.5	12.5	0.9	-0.1	3.5	-1.6	1.5	0.1	-1.3	1.9	-1.2	-1.0	-1.4
Systolic Blood Pressure	1.7	8.4	15.2	3.7	2.9	3.5	-3.2	3.2	1.9	-1.9	0.8	-3.7	-3.9	-0.3
Smoking Status	0.8	1.9	4.2	-0.3	-0.0	0.4	-1.7	1.8	-1.6	-1.3	1.4	-1.9	-2.0	0.5
Allergy or Eczema	0.4	1.0	5.0	-1.1	-0.0	-0.4	-0.2	0.1	-2.2	0.3	-1.6	-0.3	-0.6	-1.2
Cardiovascular Disease	0.6	1.9	10.1	3.2	1.3	0.3	1.0	-0.8	2.3	0.8	-0.9	0.7	0.4	-0.8
Hypothyroidism (self reported)	0.5	1.1	6.1	0.7	0.4	0.3	-0.1	-0.1	0.0	-1.4	2.5	-0.5	-0.4	-1.7
Respiratory disease	1.1	2.4	8.0	-1.8	1.2	0.7	-0.6	0.6	-2.1	-2.8	0.3	-1.3	-1.7	-1.9
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.4	0.6	-0.3	-0.5	-0.6	0.9	-0.4	1.2	-0.6	-0.5	-0.5	0.2
Lung FEV1/FVC ratio	0.2	1.2	7.7	2.8	-0.9	-0.9	0.4	0.0	0.5	-0.3	-0.1	0.2	-0.1	-1.8
Lung FVC	0.5	2.8	7.0	0.4	2.6	-2.0	2.3	-2.2	2.6	0.6	0.6	0.1	0.3	1.1
Neuroticism	0.4	0.9	3.3	-1.1	1.7	-0.2	0.8	-0.5	0.8	0.6	-1.8	-0.3	-0.5	0.4
Chronotype (morning person)	2.0	4.5	26.3	-0.1	2.9	-1.7	1.0	-1.4	0.5	-2.8	0.4	-0.4	-1.0	-5.1
Hair Pigment	0.1	2.1	5.2	-0.7	-1.9	2.0	-1.8	1.8	-2.3	0.2	0.8	-0.7	-0.5	1.3
Tanning	0.1	0.8	3.6	-0.9	-0.1	1.0	0.0	-0.1	-0.4	-0.5	-1.6	0.7	0.6	1.9
Hand grip strength (left)	1.3	3.4	10.3	2.0	3.2	1.0	-1.1	1.0	0.7	-1.4	0.8	-2.5	-2.9	-1.4
Number of treatments/medications taken	0.5	0.9	2.5	1.6	-1.1	0.6	0.4	-0.3	-0.4	1.0	-1.1	1.1	1.1	0.7
Average weekly spirits intake	0.7	0.9	5.0	-1.1	-0.6	1.2	-0.4	0.2	-2.2	-0.7	-0.7	0.2	-0.1	-0.6
Sensitivity / hurt feelings	0.3	0.6	2.6	-0.0	1.1	0.9	0.1	0.0	0.6	1.6	-1.0	-0.3	-0.2	0.5
Frequency of depressed mood in last 2 weeks	0.6	0.9	2.9	-0.2	1.7	1.3	0.1	0.0	-0.4	-0.9	0.7	-1.0	-1.2	-1.1
Hearing difficulty/problems: Yes	0.7	1.0	2.7	1.3	-0.5	-0.2	1.2	-1.2	0.3	0.9	-0.5	1.6	1.5	-0.5
Relative age of first facial hair	0.2	0.5	1.5	-0.3	-0.5	0.5	-1.1	0.9	-0.6	0.7	-1.2	-0.3	-0.4	-0.1
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	3.6	-0.2	-0.6	0.0	1.8	-1.8	-1.5	0.1	-0.4	1.9	1.7	-0.6
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.6	1.1	-1.6	0.2	-0.1	0.2	-0.9	0.9	0.2	0.6	0.9	0.3
Ever had hysterectomy (womb removed)	0.7	0.8	3.1	1.7	-0.0	-0.6	0.4	-0.3	0.8	1.3	-1.4	0.2	0.6	0.8
Systolic blood pressure, automated reading	2.5	7.2	16.1	3.6	2.3	4.0	-2.7	2.7	2.0	-1.6	2.2	-3.2	-3.0	0.3
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.9	0.2	1.0	1.4	-0.6	0.6	0.7	0.5	0.6	-0.8	-0.8	1.1
Angina	0.4	0.5	1.4	1.0	-1.2	-0.1	0.2	-0.2	0.0	0.4	-1.0	0.7	0.8	0.8
Medication for hormone replacement therapy	0.4	0.4	1.7	0.9	0.1	-0.6	-0.3	0.3	-0.7	0.4	0.3	-0.7	-0.4	-1.3
Vitamin and mineral supplements	0.7	1.0	4.3	-2.1	0.2	-0.0	-0.0	-0.3	-1.4	-0.2	-1.8	0.6	0.2	0.5
Supplements: Zinc	0.8	0.9	4.1	1.6	-1.1	2.0	-0.0	0.1	-0.1	-0.7	0.7	0.5	0.8	-0.3
Medication: Co-codamol	2.1	2.4	5.8	0.2	-1.1	1.3	-2.4	2.3	-1.8	-1.2	0.2	-1.6	-1.7	-1.4
Medication: Metformin	0.4	0.6	2.2	0.6	1.1	-1.1	0.8	-0.6	1.5	0.4	-0.2	-0.1	-0.1	0.2
Diabetes (father)	1.1	1.3	4.0	1.9	1.1	-0.8	-0.6	0.8	2.0	0.6	0.0	-1.2	-0.9	-1.3
Diabetes (mother)	0.9	1.1	3.0	0.5	1.4	0.2	-0.6	0.8	0.0	-0.8	1.0	-1.7	-1.7	-1.1
Severe depression (siblings)	0.7	0.7	2.4	0.5	-1.6	1.4	-0.8	1.1	-0.4	0.7	0.2	-0.2	0.2	0.9
Pack years adult smoking proportion	0.3	0.5	1.1	0.7	0.9	0.5	-0.5	0.2	0.7	-0.9	0.6	-0.5	-0.5	-1.1
Impedance of leg (right)	1.1	5.2	10.3	0.6	-1.0	-0.9	2.8	-2.6	2.9	2.5	-2.4	2.9	3.2	0.8
Leg fat-free mass (left)	1.3	6.9	17.8	0.7	0.8	-0.0	-3.8	3.8	-1.3	-2.3	2.0	-4.1	-4.2	-0.7
Trunk fat percentage	1.0	4.0	10.0	0.1	-2.8	1.5	-3.0	3.2	-2.0	-0.2	1.8	-1.5	-1.1	2.0
Hand grip strength (right)	0.8	2.1	6.4	0.9	2.5	0.9	-0.8	0.5	0.7	-2.0	1.3	-1.8	-2.2	-0.9
Townsend deprivation index at recruitment	0.4	0.6	3.8	-2.0	-0.7	-0.3	-0.1	0.2	-0.8	-0.6	0.6	-0.5	-0.2	0.2
Current tobacco smoking	0.5	0.9	2.2	-0.3	0.1	-0.1	-1.0	1.1	-0.9	-1.2	0.8	-1.3	-1.5	0.5
Average weekly fortified wine intake	1.6	1.9	5.2	-1.0	0.1	-0.6	1.9	-2.2	0.6	-0.5	-0.8	2.3	2.1	0.1
Maternal smoking around birth	2.1	3.1	10.4	-0.0	2.0	1.1	-1.2	1.2	0.0	-3.2	2.5	-1.8	-2.1	-1.1
Fed-up feelings	1.6	2.9	5.3	1.4	2.3	1.2	-0.7	0.9	1.8	-1.9	0.6	-2.3	-2.1	-2.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	3.5	0.9	1.9	0.6	0.3	-0.1	0.4	-1.0	1.1	-1.0	-1.1	-1.7
Relative age voice broke	0.4	0.6	2.6	-0.5	-0.7	1.1	-0.5	0.4	-0.3	0.7	-1.6	0.5	0.4	0.9
Taking other prescription medications	0.6	0.9	2.5	1.2	-1.6	0.9	-1.1	1.2	-1.0	0.5	0.1	-0.1	0.1	1.0
Age when periods started (menarche)	1.0	2.5	5.7	0.4	-1.5	-0.5	1.3	-1.2	1.1	2.4	-1.6	2.0	2.4	1.4
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.5	0.2	-0.7	-0.8	-0.9	1.2	-0.4	0.9	0.2	-1.2	-0.7	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.4	-0.4	0.3	-0.9	-1.0	1.2	0.4	-0.8	0.7	-1.5	-1.4	-0.3
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	3.8	-0.9	0.6	-1.9	1.5	-1.3	0.9	1.2	-1.7	0.5	0.6	-1.1
Qualifications: CSEs or equivalent	2.8	3.6	7.6	-2.8	1.6	0.6	-1.9	1.8	-1.4	-2.7	0.5	-2.4	-2.7	0.6
Serious illness, injury or assault to yourself	1.3	1.6	9.5	-0.6	0.3	1.7	-0.4	0.6	-3.1	-0.5	-1.7	-0.5	-0.9	-0.1
High blood pressure	1.0	2.9	13.6	3.7	2.5	0.4	1.0	-0.9	2.6	-0.3	-0.5	0.0	-0.2	-1.8
Hayfever, allergic rhinitis or eczema	0.5	1.0	6.8	-1.7	-0.3	0.2	-0.6	0.5	-2.6	0.0	-0.5	-0.4	-0.7	-0.3
Multivitamins +/- minerals	0.7	0.9	2.8	1.0	0.1	0.3	-0.5	0.9	1.0	-0.8	1.7	-1.2	-0.9	-1.0
Stomach or abdominal pain in last month	0.5	0.6	2.9	-0.6	-1.3	0.3	-0.0	0.3	-0.9	1.7	0.4	0.2	0.4	0.9
Supplements: Glucosamine	0.7	0.9	4.6	2.2	0.3	1.5	-0.4	0.8	0.8	0.0	1.1	-0.7	-0.5	0.3
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	3.6	0.4	-1.1	1.1	-1.4	1.4	-0.5	0.0	1.9	-0.7	-0.5	-0.3
Medication: Atenolol	0.8	1.0	5.9	2.4	-1.2	-0.3	-0.7	0.8	0.7	-0.1	-1.3	0.0	0.1	-0.9
Medication: Levothyroxine sodium	0.5	0.8	2.1	0.7	0.4	0.1	0.7	-0.9	-0.0	-1.4	1.4	0.8	0.7	-1.3
Sitting height	0.6	4.2	28.1	-1.6	1.0	-5.3	0.7	-0.5	0.3	-0.8	-3.3	-0.6	-1.3	-0.5
Chronic bronchitis/emphysema (father)	1.6	1.9	4.4	1.2	2.1	0.3	2.1	-2.0	1.4	0.7	0.1	1.4	1.3	-0.8
High blood pressure (mother)	3.1	4.4	10.0	2.0	3.2	1.4	-0.7	0.7	2.3	-1.8	2.6	-2.2	-1.8	-2.7
Body mass index (BMI)	1.7	7.3	17.1	1.5	-1.1	2.1	-4.1	4.1	-1.5	-1.5	3.9	-3.2	-2.9	0.2
Impedance of leg (left)	0.8	4.0	7.1	-0.3	-0.8	-1.2	2.6	-2.4	2.1	2.2	-2.4	2.6	2.7	1.0
Leg predicted mass (left)	1.3	7.0	18.2	0.7	0.8	-0.1	-3.8	3.9	-1.4	-2.2	1.9	-4.1	-4.3	-0.8
Trunk fat mass	1.1	4.7	13.6	0.5	-2.0	1.2	-3.5	3.7	-1.7	-0.7	2.0	-2.4	-2.1	1.4
Waist circumference	2.4	8.7	20.7	1.5	-1.3	2.9	-4.5	4.5	-1.4	-1.5	4.1	-3.5	-3.1	-0.1
Number of incorrect matches in round	0.6	1.0	3.0	1.6	-0.7	-1.6	0.7	-0.4	0.7	1.7	-0.3	0.1	0.5	-1.1
Past tobacco smoking	0.3	0.6	2.1	0.4	0.4	-1.0	0.7	-0.8	1.0	1.4	-0.0	0.6	0.7	-0.6
Alcohol usually taken with meals	1.2	1.9	5.7	-1.0	-1.1	0.8	0.7	-0.6	-0.5	2.4	-1.5	1.2	1.4	2.3
Nervous feelings	1.0	1.8	4.1	-0.1	0.1	-1.0	1.9	-1.9	1.4	1.1	-1.0	2.0	1.9	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	4.2	-0.1	0.9	1.6	1.0	-0.9	-0.4	-2.1	0.2	0.5	0.3	-1.4
Hearing difficulty/problems with background noise	0.4	0.7	2.3	0.1	-0.5	1.5	-0.7	0.7	-1.2	-0.7	-1.4	-0.2	-0.3	-0.2
Hair/balding pattern: Pattern 2	0.9	1.1	4.3	-1.1	0.9	0.9	-1.2	0.9	-0.0	-0.8	2.1	-1.2	-1.0	-0.1
Had menopause	0.9	1.2	3.5	0.7	-1.6	-0.4	0.6	-0.6	0.5	1.4	0.4	1.6	1.9	0.5
Had other major operations	0.6	0.7	2.5	1.5	-1.6	0.4	-0.1	0.1	-0.6	0.5	-0.6	0.4	0.5	-1.1
Forced vital capacity (FVC)	0.8	3.0	12.1	-1.2	3.5	-2.5	0.7	-0.6	1.2	-1.3	-1.1	-1.7	-2.2	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.4	-1.2	0.3	-1.0	-0.7	0.8	0.2	0.0	-0.3	-1.0	-0.9	0.5
Ever unenthusiastic/disinterested for a whole week	2.0	2.5	6.3	1.1	0.0	1.4	-2.1	2.5	-0.2	0.9	1.1	-2.5	-2.2	0.6
Qualifications: None of the above	0.2	0.5	1.0	0.5	-0.7	-0.6	0.9	-0.7	0.0	0.6	-0.2	0.9	1.0	0.7
Financial difficulties in last 2 years	0.7	1.0	4.5	0.6	0.6	0.1	-0.4	0.4	-1.0	-0.8	2.1	-1.1	-1.0	-1.1
Mouth/teeth dental problems	1.0	1.5	3.7	1.0	0.8	0.7	-1.3	1.5	0.4	-1.1	1.2	-1.9	-1.8	-0.8
Heart attack	1.8	2.3	6.7	-1.2	-2.1	-0.9	-0.1	0.2	-2.2	1.3	-2.6	1.0	0.8	1.9
Allergy	0.9	2.1	8.8	2.1	0.4	-1.2	1.3	-1.1	3.0	1.2	-0.4	1.2	1.3	0.8
Pain all over the body in last month	0.9	0.9	3.6	1.2	0.5	0.1	-0.3	0.4	-0.2	-1.4	1.3	-0.8	-0.6	-1.9
Diabetes (self-reported)	0.4	0.6	1.9	0.7	-0.4	-0.2	-1.0	1.4	-0.3	1.1	-0.1	-1.1	-0.9	0.0
Hayfever/allergic rhinitis (self-reported)	2.0	2.7	6.1	-0.6	0.4	-0.4	2.4	-2.5	-0.6	1.4	-2.1	1.9	2.0	-1.5
Medication: Ramipril	0.4	0.6	1.6	-0.1	-0.7	0.4	-1.1	1.1	-1.3	0.4	-0.7	-0.5	-0.6	-0.5
Medication: Simvastatin	1.5	2.1	5.6	2.4	-0.3	-1.6	1.8	-1.6	1.9	1.0	-0.2	1.6	1.6	0.0
Fluid intelligence score	0.6	1.2	2.7	-1.1	-0.5	0.6	-1.0	1.0	-1.5	-1.3	-1.6	-0.8	-0.8	-1.2
Illnesses of siblings	0.4	0.5	1.6	-1.2	-0.3	-1.3	0.3	-0.6	-0.0	0.2	-0.1	1.0	0.8	-0.6
Neuroticism score	0.4	0.9	4.8	-1.2	2.2	-0.2	0.7	-0.6	0.9	0.1	-0.7	-0.6	-0.7	-0.8
Weight	1.5	7.2	17.4	1.3	-0.1	0.7	-4.1	4.2	-1.1	-1.8	2.9	-4.0	-3.9	-0.2
Impedance of arm (right)	1.1	5.0	12.7	-3.6	-1.1	-1.3	2.3	-2.4	-0.5	1.4	-2.9	2.8	2.7	1.5
Arm fat percentage (right)	1.5	5.9	14.8	-0.5	-2.0	2.0	-3.9	3.8	-2.5	-1.2	2.8	-2.4	-2.1	1.2
Trunk fat-free mass	1.1	6.2	17.1	1.8	1.7	-0.8	-3.0	3.2	0.4	-2.0	1.2	-4.0	-4.1	-1.5
Hip circumference	2.1	9.3	24.1	1.1	-1.4	1.7	-4.8	4.9	-2.2	-1.3	3.6	-3.9	-3.6	0.6
Time employed in main current job	0.2	0.2	0.9	0.5	0.2	0.5	-0.2	0.2	0.8	0.9	-0.1	0.1	0.0	0.5
Alcohol intake versus 10 years previously	0.2	0.2	0.6	-0.7	-0.1	0.7	0.3	-0.3	-0.7	-0.0	0.7	0.0	0.0	-0.5
Father’s age at death	0.3	0.4	2.4	-0.6	-0.4	0.4	-0.2	-0.1	-0.1	1.6	-0.2	0.4	0.3	0.8
Worrier / anxious feelings	0.4	0.7	1.8	-1.2	1.1	-1.3	0.8	-0.6	0.7	0.5	0.9	-0.3	-0.4	0.3
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	5.9	-0.2	1.2	2.4	-0.8	0.8	-1.1	-2.1	1.0	-1.3	-1.3	-2.0
Falls in the last year	0.4	0.5	2.6	0.6	-1.6	0.2	-0.6	0.7	-0.7	0.3	-0.8	0.1	0.2	0.7
Hair/balding pattern: Pattern 3	0.8	1.1	3.7	0.8	0.6	0.2	1.5	-1.3	0.9	0.5	-1.9	1.3	0.9	0.5
Number of live births	0.5	0.7	2.7	1.2	0.5	0.1	0.7	-0.8	0.8	0.9	-1.7	0.8	0.5	-0.2
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	10.2	-0.4	3.2	-2.0	0.3	-0.2	1.2	-1.2	-0.4	-1.8	-2.2	-1.0
Pulse rate	0.8	1.4	4.3	-0.9	-2.1	0.8	-1.3	1.4	-1.9	-0.1	0.0	-0.1	-0.4	1.5
Happiness	0.4	0.5	1.4	0.6	0.8	1.2	-0.3	0.2	-0.3	-0.7	-0.2	-0.5	-0.7	-1.1
Noisy workplace	0.1	0.1	0.3	0.5	-0.3	-0.2	-0.1	0.4	0.3	0.6	-0.5	-0.4	-0.2	-0.4
Qualifications: A levels/AS levels or equivalent	0.2	0.4	2.4	-1.6	0.5	0.5	-0.1	-0.1	-1.0	-0.4	-0.7	-0.1	-0.4	-0.5
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	3.2	0.4	1.8	-1.2	1.8	-1.5	1.7	1.0	-0.1	0.1	0.1	-0.3
Mouth/teeth dental problems: Dentures	0.9	1.5	5.1	-0.4	-1.2	-0.4	0.7	-0.5	-0.8	2.2	-0.9	1.3	1.3	2.2
Asthma	0.8	1.7	3.8	-1.5	-0.3	1.7	-0.7	0.7	-2.0	-1.9	0.7	-0.8	-0.8	-1.7
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.5	-0.6	-0.1	0.5	-0.7	0.7	-0.3	-0.3	0.6	-0.5	-0.6	0.3
Medication: Cholesterol lowering	1.4	2.1	4.8	1.0	-2.1	-0.6	1.4	-1.2	-0.9	1.0	-1.1	2.2	2.2	1.3
Depression (self-reported)	0.1	0.1	0.6	0.5	0.4	0.7	-0.1	0.0	0.3	0.1	0.6	-0.2	-0.1	-0.3
Medication: Lansoprazole	0.5	0.6	2.1	1.4	-1.3	-0.5	-0.2	0.4	-0.3	1.0	-1.2	-0.1	-0.0	-0.2
Prospective memory result	0.9	1.1	5.2	2.3	-0.4	0.6	-1.2	1.4	0.7	-0.2	0.3	-1.1	-0.9	-0.2
Lung cancer (father)	2.0	2.4	5.7	-1.2	0.2	1.0	-2.2	2.3	-1.0	0.5	1.1	-2.4	-2.2	0.8
Illnesses of mother	0.6	0.7	2.8	-1.7	-0.7	-0.4	0.5	-0.6	-0.6	0.1	-0.3	1.1	0.8	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	6.4	0.1	2.5	-2.2	0.6	-0.3	1.0	-0.5	-0.7	-1.3	-1.7	-0.1
Pulse wave Arterial Stiffness index	0.3	0.4	1.5	-0.7	-0.2	0.1	-0.4	0.2	-0.7	-1.2	-0.0	-0.4	-0.6	-1.1
Impedance of arm (left)	1.3	6.0	12.3	-3.3	-1.6	-0.6	2.5	-2.7	-0.6	1.4	-3.2	3.5	3.3	1.9
Arm fat mass (right)	1.9	7.8	20.8	1.0	-1.5	1.7	-4.5	4.6	-1.9	-1.5	3.1	-3.5	-3.1	0.4
Trunk predicted mass	1.1	6.2	17.0	1.9	1.8	-0.8	-3.0	3.2	0.5	-2.1	1.3	-4.0	-4.1	-1.6
Standing height	0.3	2.7	9.8	-0.2	1.8	-3.1	-0.3	0.7	0.8	-0.9	-1.9	-2.0	-2.5	-0.7
Length of working week for main job	0.7	0.8	4.2	-0.3	0.9	-0.6	0.1	-0.2	0.2	-0.4	2.0	-0.7	-0.7	-1.4
Exposure to tobacco smoke at home	1.2	1.3	4.0	-0.9	0.3	-0.3	-1.1	1.1	-0.8	-2.0	1.0	-1.4	-1.6	-0.9
Breastfed as a baby	0.2	0.3	1.0	-0.1	0.3	1.0	0.3	-0.5	-0.0	0.8	0.4	0.5	0.7	-0.2
Tense / ‘highly strung’	0.6	1.0	3.3	-1.2	1.8	-0.2	1.2	-1.3	0.7	0.3	-0.7	0.7	0.3	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	4.4	-0.3	0.3	2.1	-1.2	1.2	-0.3	-0.3	1.5	-1.2	-1.0	0.5
Hair/balding pattern: Pattern 4	0.3	0.6	3.9	0.5	0.0	0.0	-0.3	0.2	0.4	0.5	2.0	-0.4	-0.1	1.5
Birth weight of first child	1.8	3.3	8.3	0.4	-1.2	2.0	-2.6	2.8	-2.9	-0.1	-0.8	-1.7	-1.8	0.4
Peak expiratory flow (PEF)	1.7	3.9	11.5	-0.6	2.8	-2.1	-0.9	1.1	0.5	-2.2	0.2	-2.9	-3.4	-1.8
Pulse wave reflection index	0.2	0.2	0.5	0.3	-0.5	-0.7	-0.6	0.7	-0.2	0.2	-0.0	-0.5	-0.3	-0.2
Ever highly irritable/argumentative for 2 days	1.1	1.4	3.5	1.1	0.0	0.8	-1.7	1.9	-0.3	0.1	-0.3	-1.9	-1.8	-0.0
Loud music exposure frequency	0.5	0.6	2.4	0.2	0.2	-0.7	0.6	-0.6	-0.4	-0.9	-1.6	0.6	0.2	-1.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	2.2	-1.5	0.9	-0.0	-0.4	0.2	-0.4	0.1	0.9	-0.8	-0.9	0.3
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	1.6	0.0	0.6	-0.3	1.0	-1.0	1.1	0.1	-1.3	0.4	0.4	-0.8
Blood clot in the leg (DVT)	0.3	0.4	1.9	1.4	-0.1	1.4	-0.0	-0.1	0.0	0.3	-0.3	0.3	0.4	-0.2
Medication: Paracetamol	0.3	0.6	1.8	-0.2	-1.3	1.0	-0.8	0.7	-1.1	0.5	0.8	-0.0	0.1	0.5
Headache pain in last month	0.5	0.9	5.2	-0.5	0.2	0.7	-0.9	0.9	-0.5	-0.4	2.3	-1.1	-0.8	-0.5
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	4.3	-1.6	1.5	-0.2	-1.1	0.7	0.1	-1.7	2.1	-1.5	-1.6	-1.2
Glaucoma (self-reported)	8.2	9.7	23.8	0.6	-0.6	1.2	-4.7	4.9	-1.9	-1.7	3.9	-4.3	-4.2	-0.8
Gout (self-reported)	0.5	0.7	3.6	1.4	0.5	1.9	0.1	-0.1	0.8	-1.1	-0.4	-0.3	0.1	-0.5
Hypothyroidism/myxoedema (self-reported)	0.4	0.9	3.3	0.3	0.9	-0.9	1.1	-1.2	0.2	-0.6	1.8	0.4	0.4	-1.1
Medication: Amlodipine	0.9	1.3	4.7	2.2	-1.2	-0.5	0.7	-0.6	-0.0	1.7	-0.8	1.3	1.5	0.1
Medication: Ventolin 100micrograms inhaler	1.2	1.5	3.1	-1.6	0.2	1.5	-1.0	1.1	-1.7	-1.0	1.8	-1.3	-1.1	0.5
Birth weight	0.5	1.0	5.8	-0.6	-0.4	-0.8	0.3	-0.4	-0.7	0.1	-2.4	0.8	0.5	-1.5
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.6	-0.3	-0.1	-0.8	0.3	-0.2	-0.4	0.0	0.5	-0.4	-0.1	-0.7
High blood pressure (siblings)	0.3	0.4	1.4	0.2	0.8	-0.3	0.6	-0.6	0.5	-1.2	-0.5	-0.0	-0.1	-0.9
Forced vital capacity (FVC), Best measure	0.7	2.6	10.5	-0.7	3.2	-2.6	0.7	-0.4	1.3	-0.7	-0.9	-1.6	-2.0	0.5
Body fat percentage	1.1	4.3	10.8	0.4	-2.4	1.8	-3.2	3.3	-1.7	-0.4	2.3	-1.8	-1.4	1.7
Leg fat percentage (right)	1.1	4.0	9.4	1.9	-1.9	2.2	-3.0	3.1	-0.1	-0.1	2.9	-1.8	-1.2	0.9
Arm fat-free mass (right)	1.2	6.1	14.5	2.9	1.2	-0.8	-2.9	3.2	0.8	-1.6	2.0	-3.8	-3.7	-1.1
Exposure to tobacco smoke outside home	0.9	1.2	3.9	0.1	-0.9	0.4	-1.7	2.0	-0.8	0.5	0.2	-1.5	-1.4	-0.3
Comparative body size at age 10	0.4	1.0	1.8	-0.8	1.2	0.8	-0.9	0.9	-1.2	-1.1	1.1	-1.1	-1.4	0.1
Number of full brothers	0.2	0.2	0.8	0.0	0.6	0.7	-0.4	0.3	0.2	-0.4	0.9	-0.2	-0.5	-0.1
Worry too long after embarrassment	0.9	1.5	5.5	-0.2	1.3	-1.7	0.8	-0.5	1.0	2.1	-2.3	-0.1	-0.4	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.3	0.8	-0.8	1.0	-1.0	1.2	0.2	0.7	0.3	-0.9	-0.6	-0.5
Wheeze or whistling in the chest in last year	0.9	1.6	3.6	0.5	1.0	0.9	-1.2	1.4	-0.7	-1.7	1.4	-1.9	-1.9	-0.5
Number of children fathered	0.3	0.3	0.9	-0.9	-0.2	0.3	-0.1	-0.1	-0.9	-0.9	-0.6	0.2	-0.0	0.4
Reason for reducing amount of alcohol drunk: Health precaution	2.2	2.5	5.1	1.1	0.0	-0.5	2.3	-1.9	1.2	2.3	-1.8	1.8	2.1	-0.4
Age at first live birth	1.9	3.4	6.9	-0.9	-1.3	-1.8	2.2	-2.3	0.2	0.7	-2.5	2.6	2.6	-0.9
Pulse wave peak to peak time	0.2	0.3	1.0	0.6	0.6	-0.4	0.3	-0.1	0.7	0.9	-0.1	0.1	0.1	1.0
Health satisfaction	0.9	1.2	4.4	0.3	-0.2	2.1	-1.3	1.4	-1.2	-1.1	0.6	-0.9	-1.0	-0.3
Shortness of breath walking on level ground	1.0	1.2	5.8	2.4	0.3	1.1	-0.0	0.2	0.7	-1.0	0.6	-0.4	-0.3	-2.0
Qualifications: College or University degree	0.2	0.7	2.9	-0.3	0.4	1.7	0.3	-0.7	-0.6	-0.5	0.7	0.5	0.4	-1.7
Eye problems/disorders: None of the above	2.5	2.9	6.9	0.2	0.9	-1.1	2.6	-2.6	1.5	-0.1	-2.5	1.9	1.9	-0.4
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.9	-1.4	0.2	-0.4	0.6	-0.7	-0.1	-0.2	-0.2	0.5	0.6	0.9
Emphysema/chronic bronchitis	1.4	1.6	4.0	-1.4	-0.7	1.2	-1.5	1.4	-2.0	-1.4	0.1	-1.0	-1.3	0.6
Medication for pain relief, constipation, heartburn	0.3	0.4	1.8	-0.4	1.3	-0.5	0.1	-0.2	1.0	-0.3	0.2	-0.6	-0.6	-0.8
Neck or shoulder pain in last month	0.3	0.4	0.9	0.2	-0.2	-0.9	0.7	-0.6	0.5	1.0	0.3	0.6	0.8	0.9
Medication: Blood pressure	0.7	1.2	4.5	1.9	-1.0	0.0	0.6	-0.2	0.3	1.7	-2.1	0.7	0.8	0.3
Angina (self-reported)	0.5	0.7	1.7	1.0	-1.1	-0.6	0.5	-0.5	0.1	0.6	-1.3	0.9	1.0	0.7
Migraine (self-reported)	0.5	0.6	4.7	-0.9	0.4	-0.3	0.3	-0.2	0.1	2.2	-0.6	-0.0	0.1	0.8
Medication: Ibuprofen	0.2	0.2	1.1	-0.4	-0.3	1.0	-0.3	0.2	-0.5	0.0	0.5	0.1	-0.0	0.2
Medication: Allopurinol	0.5	0.7	4.3	0.8	-0.3	2.1	-0.6	0.6	0.1	-0.4	-1.0	-0.4	-0.1	-0.5
Medication: Omeprazole	1.0	1.2	2.6	0.5	-1.6	-0.3	1.1	-0.9	-0.6	0.3	-1.5	1.5	1.5	1.1
Medication: Seretide 50 evohaler	0.3	0.4	1.7	0.2	0.3	0.1	-0.4	0.3	-0.3	-0.4	0.1	-0.8	-1.0	-1.3
Mean time to correctly identify matches	0.6	1.1	2.5	1.1	-1.4	1.3	0.0	0.3	0.4	1.6	0.9	0.4	1.0	1.5
Heart disease (mother)	1.2	1.5	3.6	0.3	-0.7	-0.2	1.8	-1.5	-0.1	1.1	-1.3	1.8	1.9	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.5	-1.0	0.4	-0.3	-0.3	0.3	-0.7	0.8	-1.2	-0.7	-0.8	-0.4
Whole body fat mass	1.5	6.1	16.4	1.1	-1.3	1.5	-3.9	4.0	-1.3	-1.2	2.8	-3.1	-2.8	0.8
Leg fat mass (right)	1.4	5.6	14.3	1.7	-1.0	1.5	-3.6	3.8	-0.7	-1.1	3.2	-3.0	-2.6	0.4
Arm predicted mass (right)	1.1	5.6	13.6	2.6	1.0	-0.7	-2.9	3.2	0.6	-1.4	2.1	-3.7	-3.6	-0.9
Pulse rate, automated reading	0.7	2.1	6.1	1.6	-1.5	0.4	-1.6	2.0	-0.0	0.1	1.8	-1.2	-1.2	2.5
Alcohol intake frequency.	0.3	0.7	2.6	1.2	0.2	-0.4	-0.1	0.4	1.0	1.6	0.7	-0.8	-0.6	-0.6
Comparative height size at age 10	0.3	1.7	6.2	-0.1	1.0	-2.5	-0.6	1.0	0.2	-0.1	-1.6	-1.6	-2.0	-0.9
Number of full sisters	0.5	0.6	1.8	-0.2	-0.0	-0.3	-0.9	1.1	-0.0	-0.8	0.8	-1.3	-1.3	0.3
Suffer from ‘nerves’	0.8	1.3	3.3	-0.6	0.4	-1.8	1.7	-1.5	0.8	1.3	-0.5	0.8	0.9	-1.0
Overall health rating	0.7	1.5	5.7	-0.4	-0.3	0.8	-1.3	1.4	-2.4	-1.4	1.2	-1.0	-1.2	-0.1
Chest pain or discomfort	0.2	0.3	0.8	0.5	0.2	-0.8	0.8	-0.7	-0.3	0.1	0.1	0.6	0.5	-0.9
Had major operations	3.7	4.4	11.1	-0.1	-3.3	1.6	0.6	-0.7	-1.9	2.3	-2.7	2.4	2.7	2.2
Age at last live birth	1.2	1.8	4.4	-0.1	-0.4	-0.4	2.0	-2.1	0.5	1.0	-1.1	1.9	2.1	-0.8
Family relationship satisfaction	0.8	1.0	3.1	-0.2	1.6	1.4	0.0	-0.1	-1.2	-0.8	-0.7	-0.3	-0.7	-1.8
Leg pain on walking	1.0	1.2	5.8	1.1	-2.4	-1.0	-0.0	0.1	0.0	2.0	-0.5	0.7	1.0	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	2.2	0.8	0.0	0.5	-1.2	1.4	-0.0	0.5	-1.0	-1.2	-1.2	1.5
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.0	0.6	0.1	1.0	0.8	-0.7	-0.4	-0.4	-1.0	0.9	0.7	0.5
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	5.2	-1.2	-1.2	-0.6	0.5	-0.7	0.2	0.7	-0.9	1.5	1.5	2.3
Medication: Aspirin	1.8	2.4	4.7	1.6	0.2	0.2	1.9	-1.8	1.4	1.2	-0.9	2.1	2.2	1.7
Supplements: Vitamin C	0.8	0.9	3.6	1.9	-0.1	-1.1	1.3	-1.0	0.6	0.6	-0.6	0.9	0.7	0.0
Knee pain experienced in last month	0.5	0.8	2.3	1.1	-1.4	0.4	-0.2	-0.0	-1.2	0.2	-0.2	0.8	0.8	-1.5
Hypertension (Self-reported)	1.0	2.8	15.9	4.0	2.1	0.7	0.7	-0.6	2.5	-0.1	-0.3	-0.1	-0.1	-1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.5	3.8	0.2	-0.5	-1.1	1.7	-1.6	0.4	0.4	-1.9	1.6	1.5	-0.2
Illnesses of father: Heart disease	2.5	3.5	9.1	-0.8	-1.2	-1.6	2.6	-2.5	0.1	-0.6	-1.4	3.0	2.9	0.8
Illnesses of siblings: Diabetes	0.9	1.1	2.8	1.3	0.6	0.6	-0.9	1.1	0.9	0.2	1.7	-1.5	-1.3	0.5
Smoking status: Previous	0.6	0.9	1.6	-0.9	-0.6	1.1	-1.2	1.3	-1.1	-0.7	0.2	-0.8	-0.8	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	5.5	-1.4	1.2	-0.7	-1.1	1.3	-0.4	-1.6	0.1	-1.9	-2.4	-0.4
Whole body fat-free mass	1.3	7.3	20.1	1.7	1.4	-0.6	-3.6	3.8	-0.2	-2.2	1.7	-4.4	-4.5	-1.3
Leg fat-free mass (right)	1.4	7.6	20.7	0.2	1.1	-0.3	-3.8	3.8	-1.7	-2.5	2.0	-4.3	-4.5	-0.8
Arm fat percentage (left)	1.4	5.7	14.1	-0.4	-2.2	2.3	-3.8	3.7	-2.5	-1.3	2.8	-2.1	-1.8	1.2
Average weekly red wine intake	0.5	0.8	2.5	-0.0	1.2	0.3	-0.8	0.9	0.1	-0.9	0.2	-1.3	-1.6	-0.4
Handedness (chirality/laterality): Left-handed	1.1	1.3	6.5	0.2	2.5	-1.2	0.8	-0.7	1.1	-0.4	0.5	-1.1	-1.1	-0.9
Mood swings	0.8	1.5	4.6	-1.1	1.3	2.2	-0.8	0.5	-0.2	-2.1	1.2	-0.9	-0.9	-0.6
Loneliness, isolation	1.5	2.1	6.8	0.6	1.2	0.5	-1.4	1.3	0.6	-0.6	1.2	-2.1	-2.0	-2.6
Long-standing illness, disability or infirmity	0.4	0.6	4.2	0.3	-0.9	0.3	-0.4	0.4	-2.0	0.3	-0.3	0.4	0.1	0.5
Ever had bowel cancer screening	0.6	0.7	2.4	-0.5	-0.4	-1.6	0.6	-0.7	0.5	1.4	-0.2	1.0	0.8	-0.1
Diabetes diagnosed by doctor	0.3	0.5	1.8	1.3	0.5	-0.7	-0.1	0.4	1.2	0.5	-0.1	-0.7	-0.5	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	7.4	2.7	-0.2	1.3	-0.5	0.6	0.9	1.2	0.9	-0.6	0.0	-0.4
Friendships satisfaction	0.5	0.6	2.1	0.3	0.7	0.9	-0.6	0.5	-0.4	-0.6	-0.3	-0.9	-0.9	-1.4
Qualifications: nursing, teaching	0.5	0.7	1.8	0.7	0.3	-0.3	1.3	-1.3	1.0	0.2	-0.5	0.9	0.8	-1.2
Commuting to job workplace: Walk	1.7	1.8	4.8	-0.8	1.7	-1.4	2.1	-2.2	0.4	1.0	-0.2	1.3	1.0	-0.9
Eye problems/disorders: Cataract	0.8	0.9	5.2	-0.1	2.3	-0.1	0.3	-0.2	1.2	-0.2	0.9	-0.5	-0.8	-1.0
Mouth/teeth dental problems: Mouth ulcers	1.3	2.0	4.7	-1.8	-1.7	-1.0	1.1	-1.4	-1.0	1.0	-0.6	2.1	2.2	0.5
Medication for cholesterol	0.9	1.4	4.9	-2.2	-1.0	0.7	-1.4	1.5	-1.3	-0.7	0.1	-1.1	-1.0	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	8.4	1.4	1.3	-1.9	0.3	-0.3	0.4	0.2	0.3	-0.8	-1.1	-2.9
Back pain experienced in last month	1.3	2.0	6.3	-1.9	-0.5	-1.4	1.2	-0.9	-1.3	1.9	-2.5	0.6	0.4	1.0
Mineral and other dietary supplements	1.9	2.6	17.1	-4.1	-1.2	-0.6	-0.8	0.4	-2.5	-1.1	-1.0	0.2	-0.1	0.2
Breast cancer (self-reported)	1.3	1.6	3.7	-1.0	-1.9	0.9	-0.6	0.3	-1.2	1.7	-1.7	0.9	0.9	1.6
Asthma (self-reported)	0.9	1.7	4.5	-1.5	-0.3	2.0	-0.7	0.7	-2.1	-1.8	1.0	-0.8	-0.7	-1.4
Osteoporosis (self-reported)	0.4	0.5	2.0	-0.8	0.2	0.3	-0.7	0.6	-1.4	-0.3	-0.2	-0.6	-0.9	-0.3
Osteoarthritis (self-reported)	1.1	1.4	3.9	0.1	0.0	-0.0	-1.4	1.3	-0.1	-1.1	2.0	-1.3	-1.3	-1.7
Medication: Aspirin	0.9	1.2	2.4	1.1	0.1	0.4	1.2	-1.1	0.6	0.9	-1.0	1.5	1.4	1.6
Medication: Gliclazide	0.0	0.1	0.2	0.2	0.3	0.1	0.1	-0.1	0.2	-0.0	0.3	-0.0	-0.1	0.5
Illnesses of father: None of the above (group 1)	1.4	1.7	4.3	0.9	-2.1	1.2	-1.7	1.8	-1.7	1.1	0.5	-1.0	-0.6	0.6
Smoking status: Current	0.5	0.7	2.2	0.2	0.4	-0.4	-0.8	0.9	-0.7	-1.2	0.6	-1.3	-1.5	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.1	-1.0	-0.1	-1.0	0.6	-0.5	-0.0	0.7	-0.6	0.1	0.2	1.0
Whole body water mass	1.2	7.0	19.2	1.6	1.3	-0.6	-3.5	3.7	-0.3	-2.1	1.7	-4.3	-4.4	-1.2
Leg predicted mass (right)	1.5	8.1	21.8	0.2	1.1	-0.2	-4.0	4.0	-1.8	-2.6	2.1	-4.4	-4.7	-0.9
Arm fat mass (left)	1.6	6.7	17.1	0.6	-1.3	1.6	-4.1	4.1	-1.9	-1.7	3.2	-3.2	-2.9	0.3
Number of self-reported non-cancer illnesses	0.3	0.4	1.5	1.0	-0.7	1.2	-0.5	0.7	-0.9	0.1	-0.2	-0.1	0.0	-0.2
Average weekly champagne plus white wine intake	1.3	1.7	7.4	-2.7	-0.4	-0.3	1.2	-1.4	-1.7	-0.6	0.2	1.6	1.5	0.2
Miserableness	1.3	2.2	7.3	-0.2	2.7	1.2	-0.7	0.8	1.5	-1.1	1.4	-2.1	-2.1	-0.5
Guilty feelings	0.5	0.7	4.0	1.0	0.2	0.1	0.2	-0.2	1.1	1.0	-2.0	0.2	0.4	-0.7
Wears glasses or contact lenses	0.7	0.8	3.2	1.0	-0.7	-0.1	-0.7	0.9	0.5	1.5	1.8	-0.5	-0.0	0.8
Ever taken oral contraceptive pill	0.6	0.7	1.8	-1.0	-0.9	0.4	-1.1	0.9	-0.2	-1.4	0.0	-0.5	-0.6	0.8
Hearing aid user	1.1	1.2	2.9	-1.7	-1.4	0.5	-0.8	0.7	-1.7	-0.4	-1.5	0.3	0.1	1.2
Mother’s age at death	1.5	1.8	4.2	-0.5	-2.0	0.6	0.7	-0.6	-0.8	1.0	-1.7	2.0	2.1	1.3
Financial situation satisfaction	0.7	0.9	2.6	1.0	0.8	0.0	-0.6	0.7	-0.9	-0.3	-0.6	-1.2	-1.4	-1.6
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.4	0.2	1.6	-0.8	-0.2	0.3	0.8	-0.3	0.4	-0.8	-1.1	0.4
Commuting to job workplace: Public transport	0.7	0.9	2.7	-0.6	0.2	1.2	-1.6	1.4	-0.2	0.3	-0.6	-1.1	-1.2	-0.0
Eye problems/disorders: Glaucoma	8.0	9.5	24.0	1.4	-0.4	1.9	-4.7	4.9	-1.1	-1.7	3.7	-4.3	-4.1	-0.4
Medication: Blood pressure	0.6	1.1	4.0	2.0	1.3	1.0	0.8	-0.9	1.5	-0.5	-0.1	0.7	0.6	-1.0
Pain type(s) experienced in last month: Hip pain	1.9	2.3	5.6	-2.1	-0.4	-1.6	-1.4	1.6	-2.4	-0.7	0.3	-1.9	-2.1	-0.2
Supplements: Fish oil (including cod liver oil)	1.8	2.4	14.2	3.8	1.4	-0.7	0.8	-0.4	2.6	0.9	0.9	-0.3	-0.1	-0.5
High cholesterol (Self-reported)	1.4	2.6	8.2	2.9	1.1	-0.8	1.7	-1.3	2.4	2.3	0.6	0.8	0.9	0.7
Medication: Bendroflumethiazide	0.6	1.0	2.7	0.4	0.0	1.6	-1.6	1.6	-0.0	-0.6	0.1	-1.1	-1.0	0.2
Medication: Paracetamol	0.3	0.4	1.3	0.4	-1.1	0.8	-0.2	0.3	-0.6	1.1	0.4	0.2	0.3	0.5
Medication: Lisinopril	0.2	0.3	1.5	0.3	0.2	0.2	0.6	-0.4	1.2	0.3	-0.4	0.3	0.5	0.5
Medication: Atorvastatin	0.4	0.5	1.1	0.1	-0.9	1.0	-0.8	0.9	-0.9	0.4	0.6	-0.5	-0.5	0.9
Illnesses of father: High blood pressure	1.2	1.5	8.0	-0.8	2.8	-0.9	1.0	-0.8	1.7	-0.5	0.3	-0.8	-1.1	0.3
Alcohol drinker status: Never	0.6	0.7	1.8	0.5	0.9	-1.4	1.1	-0.9	1.2	0.7	0.4	0.2	0.3	-0.1
Ever smoked	0.2	0.4	1.8	-0.6	-0.4	1.3	-0.1	-0.1	-0.6	-0.8	-0.6	0.3	0.2	0.6
Basal metabolic rate	1.4	7.7	20.2	1.5	1.1	-0.2	-3.8	4.0	-0.4	-2.3	2.1	-4.4	-4.5	-1.1
Leg fat percentage (left)	1.3	4.6	11.6	1.3	-1.8	2.1	-3.3	3.4	-0.8	-0.3	3.0	-2.2	-1.7	1.1
Arm fat-free mass (left)	1.4	7.0	17.9	2.6	1.3	-0.6	-3.2	3.5	0.5	-1.9	2.2	-4.2	-4.1	-1.3
Number of operations (self-reported)	2.7	4.1	12.8	1.6	-2.6	-0.3	1.0	-0.7	-1.4	3.2	-3.6	1.9	1.9	1.3
Average weekly beer plus cider intake	0.5	0.7	1.5	-1.1	-0.3	-0.6	-1.2	1.2	-0.5	-0.2	-0.2	-1.1	-1.1	0.5
Irritability	1.1	1.8	7.8	0.2	2.8	0.8	1.3	-1.2	1.3	-1.6	0.4	-0.3	-0.5	-1.8
Risk taking	0.9	1.4	8.6	2.5	0.3	-0.0	-0.2	0.2	0.1	0.3	0.1	-0.3	-0.3	-2.9
Ever had prostate specific antigen (PSA) test	1.3	1.5	2.8	-0.3	-1.0	-0.2	1.5	-1.5	-1.2	0.4	-1.6	1.7	1.6	-1.2
Fractured/broken bones in last 5 years	0.7	0.9	2.9	1.5	0.3	0.6	-0.9	0.8	0.8	-0.8	1.2	-0.6	-0.5	-1.7
Age started oral contraceptive pill	2.0	2.5	6.4	0.3	-2.2	-1.9	1.1	-0.9	0.4	2.5	-1.7	1.6	2.0	1.2
Diastolic blood pressure, automated reading	0.3	1.0	2.1	1.3	0.9	1.4	-1.4	1.3	-0.4	-0.0	-0.3	-1.1	-1.3	-0.2
Ever depressed for a whole week	1.2	1.5	3.4	0.5	0.4	1.0	-1.3	1.6	0.6	1.4	1.2	-1.9	-1.4	1.2
Unable to work because of sickness or disability	0.4	0.5	2.6	-0.3	-1.2	1.0	0.2	0.2	-1.6	-0.3	-0.3	0.2	0.5	0.5
Commuting to job workplace: Cycle	0.5	0.6	2.9	-0.1	-0.5	-0.6	0.7	-0.6	-0.0	0.3	-1.1	0.6	0.4	-1.7
Myopia	0.5	0.7	2.9	-0.7	-0.0	-0.1	-0.5	0.5	-1.7	-0.8	-0.5	-0.5	-0.7	-1.3
Vascular/heart problems diagnosed by doctor	0.9	2.4	14.1	-3.8	-1.8	-0.6	-0.9	0.8	-2.0	0.0	1.2	-0.3	-0.1	1.4
Cholesterol lowering medication	1.7	2.5	8.2	2.5	0.6	-1.1	1.5	-1.5	2.9	1.7	0.0	1.3	1.4	0.2
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	2.0	0.2	-0.7	-0.5	1.4	-1.2	-0.5	-0.7	-1.1	1.4	1.2	0.7
Pain experienced in last month	0.2	0.4	1.9	0.6	0.9	1.4	-0.0	-0.1	0.7	-0.6	0.2	0.1	-0.0	0.2
Supplements: Calcium	1.1	1.2	4.6	1.4	-1.1	0.4	0.1	0.1	-0.6	2.1	-2.1	0.4	0.5	0.2
Basal cell carcinoma (self-reported)	0.4	0.4	1.9	0.4	0.2	1.4	-0.2	0.2	-0.8	-0.9	0.3	-0.4	-0.3	0.7
Heart attack/myocardial infarction (self-reported)	1.5	1.9	5.4	-1.0	-1.9	-0.8	-0.1	0.2	-1.9	1.1	-2.3	0.9	0.7	2.0
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	2.2	1.5	-0.2	1.2	-0.0	-0.1	0.0	0.5	-0.6	0.3	0.5	-0.2
Heart disease (siblings)	0.5	0.6	2.0	0.5	-0.6	-0.8	0.6	-0.3	0.2	1.4	-0.8	0.3	0.4	1.3
Alcohol drinker status: Previous	0.6	0.6	3.6	-0.1	-0.6	-0.5	0.3	-0.2	-1.1	0.9	-1.9	0.7	0.4	0.4
Pack years of smoking	0.2	0.3	0.8	0.8	0.3	0.6	-0.4	0.1	0.6	-0.8	0.4	-0.1	-0.0	-0.9
Impedance of whole body	1.1	5.6	11.1	-2.0	-1.2	-1.0	2.9	-2.9	1.0	1.7	-3.2	3.3	3.3	1.6
Leg fat mass (left)	1.5	5.9	15.0	1.4	-1.0	1.4	-3.7	3.9	-1.0	-1.2	3.3	-3.1	-2.8	0.8
Arm predicted mass (left)	1.4	7.0	17.9	2.6	1.2	-0.6	-3.2	3.5	0.5	-2.0	2.2	-4.2	-4.1	-1.3