Best TWAS P=1.23e-17 · Best GWAS P=8.53e-19 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | RP11-489E7.4 | 0.16 | 0.00 | lasso | 3 | 0.00 | 2.8e-01 | -6.3 | 6.3 | 2.2e-10 | -0.66 | 0.04 | 0.66 | FALSE |
| 2 | GTEx | Brain Putamen basal ganglia | GSR | 0.26 | -0.01 | enet | 24 | 0.00 | 3.3e-01 | 1.7 | 5.5 | 5.0e-08 | -0.37 | 0.05 | 0.13 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | GTF2E2 | 0.08 | 0.00 | enet | 22 | 0.01 | 8.7e-02 | -8.6 | -5.6 | 1.8e-08 | 0.61 | 0.03 | 0.79 | FALSE |
| 4 | GTEx | Esophagus Muscularis | GTF2E2 | 0.24 | 0.07 | enet | 12 | 0.11 | 3.9e-07 | -4.9 | -5.3 | 1.2e-07 | 0.52 | 0.62 | 0.28 | FALSE |
| 5 | YFS | Blood | LEPROTL1 | 0.10 | 0.11 | bslmm | 386 | 0.12 | 8.1e-37 | 4.8 | 5.2 | 2.1e-07 | -0.03 | 1.00 | 0.00 | TRUE |
| 6 | YFS | Blood | TMEM66 | 0.03 | 0.00 | blup | 384 | 0.01 | 3.5e-05 | 2.0 | 5.2 | 2.2e-07 | -0.41 | 0.01 | 0.95 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RBPMS | 0.07 | 0.05 | lasso | 2 | 0.05 | 9.7e-07 | -8.9 | -8.6 | 1.2e-17 | 0.97 | 0.00 | 1.00 | TRUE |