Hub : Genes

RBPMS

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.1230	0.0490	3.0e-03	0.077	NA	0.039	NA	0.049	2.6e-04	NA	7.8e-03	NA	3.2e-03
2	ROSMAP	Brain Pre-frontal Cortex	0.0852	0.0301	1.8e-04	0.040	0.028	0.054	0.036	0.051	6.1e-06	1.3e-04	1.7e-07	1.6e-05	3.7e-07
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0693	0.0298	3.8e-06	0.052	0.052	0.054	NA	0.054	1.5e-06	1.4e-06	1.0e-06	NA	9.7e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.4	0.6	1.1	1.1	-0.0	-0.8
Bipolar Disorder or Schizophrenia	0.1	0.3	0.6	-0.0	0.8	0.6
Depressed Affect (Nagel 2018)	0.5	1.1	2.3	0.4	-1.5	0.8
Depression (Nagel 2018)	0.3	0.4	1.1	1.0	-0.1	0.2
Intelligence (Savage-Jansen 2018)	0.5	1.5	1.6	1.2	1.3	-1.3
Neuroticism (Nagel 2018)	0.4	0.9	2.4	0.4	-1.6	0.4
Schizophrenia (2018)	0.6	1.3	2.0	-0.9	1.0	1.4
Schizophrenia vs Biploar Disorder	0.8	1.0	1.7	-0.6	-1.0	1.3
Worry (Nagel 2018)	0.2	0.4	1.0	1.0	-0.4	0.4
Alzheimer’s Disease (in mother)	0.3	0.3	0.5	0.7	-0.6	0.4
Alzheimer’s Disease (in father)	0.3	0.3	0.8	0.1	-0.9	0.1
Alzheimer’s Disease (including proxy)	0.1	0.2	0.6	0.8	0.2	0.0
Crohns Disease (2017)	0.0	0.1	0.2	0.5	-0.2	-0.2
Irritable Bowel Disease (IBD)	0.1	0.2	0.3	-0.5	-0.4	0.3
Ulcerative Colitis (UC)	0.4	0.7	1.6	-1.3	-0.2	0.8
Major Depression (MDD)	0.6	0.8	1.2	-0.7	0.8	1.1
Reaction Time	1.4	2.8	5.6	-2.4	1.6	-0.2
Verbal and Numeric Reasoning (VNR)	0.6	1.5	2.2	1.2	0.8	-1.5
Breast Cancer	1.8	4.3	8.4	-0.5	2.1	-2.9
Ovarian Cancer	0.6	0.8	1.4	-1.2	1.0	-0.0
Prostate Cancer	1.8	2.5	2.6	-1.6	-1.6	1.5
Age at First Birth	0.1	0.1	0.2	0.1	-0.1	0.5
Bipolar Disorder (2011)	3.0	2.9	4.2	1.6	2.1	-1.4
Body Mass Index (BMI) (2010)	0.6	0.8	1.8	0.4	1.3	-0.7
Coronary Artery Disease (CAD)	0.3	0.3	0.7	0.1	-0.5	0.8
Crohns Disease (2012)	0.3	0.5	1.3	-0.4	0.2	-1.2
Mean Putamen Volume	0.5	0.5	0.9	1.0	-0.3	-0.8
Fasting Glucose	0.4	0.4	0.8	-0.9	-0.5	0.4
HbA1C	1.0	1.1	3.1	1.8	0.5	-0.3
HDL Cholesterol	0.4	0.6	1.3	0.7	-1.1	-0.2
LDL Cholesterol	0.3	0.5	0.9	0.4	-0.6	-1.0
Lupus	2.3	3.6	7.4	-1.7	2.7	0.6
Neuroticism (2016)	0.9	1.3	3.0	0.1	1.0	-1.7
Primary Biliary Cirrhosis	0.1	0.1	0.2	-0.4	0.5	-0.1
Rheumatoid Arthritis	3.7	5.1	13.4	-0.3	-1.4	3.7
Schizophrenia (2014)	0.6	1.4	2.1	-0.7	1.4	1.2
Triglycerides	1.4	2.4	4.6	1.5	-2.1	0.3
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.7	-0.3	0.5	-0.8
Ulcerative Colitis	0.4	0.6	1.2	-1.1	0.7	0.4
Blood Eosinophil Count	1.3	9.8	21.8	0.1	2.8	-4.7
Blood Platelet Count	2.1	24.7	73.1	-0.9	0.5	-8.6
Blood Red Count	0.5	4.6	9.8	-0.5	-1.9	-3.1
Blood White Count	1.9	14.0	32.9	-0.5	-3.0	-5.7
Heel T-Score	0.3	2.3	5.7	-0.3	-1.1	-2.4
BMI	0.6	3.7	10.1	-1.0	-3.2	-0.2
Height	1.1	21.5	45.7	3.7	-2.2	-6.8
Waist Hip Ratio (WHR)	0.2	0.9	1.6	1.3	1.0	0.3
Systolic Blood Pressure	0.1	0.4	0.7	0.6	0.8	0.6
Smoking Status	0.5	1.1	1.9	0.9	-1.4	0.7
Allergy or Eczema	0.4	1.1	3.2	-0.2	0.5	1.8
Cardiovascular Disease	1.0	3.2	6.5	-1.3	1.2	2.5
Hypothyroidism (self reported)	1.0	2.2	3.3	-1.8	-0.6	1.8
Respiratory disease	0.5	1.2	2.7	-0.8	1.6	-0.5
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.5	0.5	-0.6	-1.2
Lung FEV1/FVC ratio	0.4	2.0	4.0	1.1	2.0	-0.8
Lung FVC	1.2	5.9	15.5	-0.8	-1.3	3.9
Neuroticism	0.2	0.5	0.8	0.0	-0.9	0.9
Chronotype (morning person)	0.4	1.0	1.2	1.0	0.8	-1.1
Hair Pigment	0.1	2.1	4.5	-1.1	-2.1	0.8
Tanning	0.1	1.7	4.2	-0.4	2.0	-0.9
Hand grip strength (left)	0.5	1.3	1.8	1.0	-1.4	-1.1
Number of treatments/medications taken	1.0	1.8	5.3	-0.2	0.4	2.3
Average weekly spirits intake	2.5	3.1	8.0	2.8	-0.9	-0.8
Sensitivity / hurt feelings	0.3	0.5	1.3	1.1	-0.1	-0.6
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.8	-0.2	0.5	-0.9
Hearing difficulty/problems: Yes	0.2	0.3	0.5	0.7	-0.3	-0.6
Relative age of first facial hair	0.4	0.8	1.3	-0.9	-1.2	0.4
Other serious medical condition/disability diagnosed by doctor	1.7	2.2	3.4	1.8	0.3	1.8
Ever used hormone-replacement therapy (HRT)	1.2	1.6	3.6	0.2	-1.0	1.9
Ever had hysterectomy (womb removed)	1.9	2.1	6.0	-0.3	0.5	2.5
Systolic blood pressure, automated reading	0.2	0.5	0.8	-0.2	-0.9	0.8
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	1.8	1.2	1.4	-0.2
Angina	2.2	2.9	7.0	-1.3	0.2	2.6
Medication for hormone replacement therapy	1.6	1.8	2.9	-1.7	-0.4	1.5
Vitamin and mineral supplements	0.3	0.4	0.9	-1.0	-0.3	-0.4
Supplements: Zinc	0.7	0.8	1.7	1.3	-0.6	-0.4
Medication: Co-codamol	0.3	0.3	0.8	0.2	-0.9	-0.4
Medication: Metformin	0.9	1.2	1.9	-1.4	0.4	-1.3
Diabetes (father)	0.2	0.2	0.3	0.1	0.6	-0.6
Diabetes (mother)	1.1	1.5	2.4	-1.2	1.6	-0.6
Severe depression (siblings)	2.1	2.3	3.2	1.8	-1.0	1.6
Pack years adult smoking proportion	0.6	0.9	2.0	-1.4	-0.7	0.5
Impedance of leg (right)	0.2	1.1	2.3	0.6	1.5	-0.8
Leg fat-free mass (left)	1.0	5.4	13.4	1.3	-3.7	-1.1
Trunk fat percentage	0.9	3.7	10.7	-0.7	-3.3	-0.3
Hand grip strength (right)	0.3	0.8	1.7	0.9	0.0	-1.3
Townsend deprivation index at recruitment	0.0	0.1	0.2	0.1	-0.1	0.4
Current tobacco smoking	0.1	0.2	0.3	-0.6	-0.3	0.2
Average weekly fortified wine intake	1.0	1.1	2.2	0.1	1.5	-1.1
Maternal smoking around birth	1.3	1.8	4.6	-0.8	-2.1	0.6
Fed-up feelings	0.7	1.4	2.3	-1.2	-1.5	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.0	-0.6	-0.6	1.4
Relative age voice broke	0.8	1.3	1.8	-1.3	-1.1	-0.9
Taking other prescription medications	0.7	1.1	2.2	-0.9	0.5	1.5
Age when periods started (menarche)	0.4	1.0	2.1	-0.9	1.4	0.3
Bilateral oophorectomy (both ovaries removed)	2.1	2.4	6.5	-0.1	-0.9	2.5
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	3.2	0.2	-1.8	-0.7
Tinnitus: Yes, but not now, but have in the past	2.0	2.1	5.6	2.4	0.8	-0.5
Qualifications: CSEs or equivalent	0.4	0.5	1.2	0.3	-0.4	1.1
Serious illness, injury or assault to yourself	1.8	2.1	6.1	0.3	0.4	2.5
High blood pressure	1.1	3.1	5.1	-1.3	1.6	2.3
Hayfever, allergic rhinitis or eczema	0.5	1.1	3.1	-0.0	0.4	1.8
Multivitamins +/- minerals	0.3	0.3	0.9	0.0	1.0	0.3
Stomach or abdominal pain in last month	4.1	5.1	13.6	-1.3	-0.2	3.7
Supplements: Glucosamine	0.4	0.6	1.3	-1.2	0.6	-0.2
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	2.6	1.6	-0.3	-0.5
Medication: Atenolol	1.2	1.5	2.0	-1.3	-1.0	1.4
Medication: Levothyroxine sodium	0.3	0.5	1.0	-1.0	-0.4	0.5
Sitting height	1.2	8.2	12.9	2.9	-3.6	-1.8
Chronic bronchitis/emphysema (father)	0.5	0.6	1.6	-1.3	0.0	0.5
High blood pressure (mother)	0.7	0.9	2.1	-1.4	-0.4	0.7
Body mass index (BMI)	0.9	3.9	10.4	-0.4	-3.2	1.0
Impedance of leg (left)	0.2	0.9	1.7	0.6	1.3	-0.7
Leg predicted mass (left)	1.0	5.2	13.1	1.2	-3.6	-1.0
Trunk fat mass	1.2	5.2	15.2	-0.1	-3.9	-0.6
Waist circumference	1.3	4.7	13.2	0.8	-3.6	-0.4
Number of incorrect matches in round	0.3	0.4	1.0	-0.2	1.0	-0.5
Past tobacco smoking	3.2	5.9	13.5	-2.0	3.7	-0.6
Alcohol usually taken with meals	0.2	0.3	0.9	-0.1	-0.9	0.1
Nervous feelings	0.6	1.0	3.0	0.1	-0.3	1.7
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.4	0.0	-0.6	0.3
Hearing difficulty/problems with background noise	0.1	0.2	0.4	0.5	-0.6	0.2
Hair/balding pattern: Pattern 2	0.7	0.9	2.1	-0.1	-0.8	1.5
Had menopause	2.3	2.8	4.9	-0.9	-1.7	2.2
Had other major operations	0.5	0.7	1.0	1.0	0.2	1.0
Forced vital capacity (FVC)	0.7	2.9	6.0	2.5	-1.1	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.3	2.8	-0.2	-1.7	-1.0
Ever unenthusiastic/disinterested for a whole week	1.8	2.2	3.6	0.8	-1.6	1.9
Qualifications: None of the above	0.2	0.5	0.9	0.4	-1.0	0.7
Financial difficulties in last 2 years	0.7	1.0	2.7	-1.6	-0.2	0.5
Mouth/teeth dental problems	0.5	0.8	1.6	-1.3	-0.7	0.6
Heart attack	2.4	3.0	7.9	0.0	-1.1	2.8
Allergy	0.9	2.2	5.3	0.6	-0.9	-2.3
Pain all over the body in last month	1.0	1.1	2.0	1.4	0.9	-0.7
Diabetes (self-reported)	0.4	0.6	0.8	-0.9	0.5	-0.8
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.2	0.7	1.1	-0.6
Medication: Ramipril	0.8	1.0	2.2	0.3	0.8	-1.5
Medication: Simvastatin	0.8	1.2	3.5	-0.2	-0.2	1.9
Fluid intelligence score	0.8	1.6	3.8	1.0	0.2	-2.0
Illnesses of siblings	3.0	4.2	7.1	1.1	2.7	-2.1
Neuroticism score	0.2	0.4	0.8	-0.3	-0.9	0.5
Weight	1.3	6.3	16.8	1.3	-4.1	-0.8
Impedance of arm (right)	0.6	2.8	7.0	-0.5	1.2	-2.6
Arm fat percentage (right)	0.8	3.3	8.8	-1.1	-3.0	-0.4
Trunk fat-free mass	1.2	6.8	9.7	2.8	-3.1	-1.7
Hip circumference	1.4	6.1	17.3	0.1	-4.2	-0.9
Time employed in main current job	0.8	0.9	2.1	-0.6	0.4	-1.4
Alcohol intake versus 10 years previously	0.5	0.8	1.0	0.9	1.0	0.7
Father’s age at death	1.7	2.3	6.4	-0.1	0.7	-2.5
Worrier / anxious feelings	0.1	0.2	0.3	0.2	0.4	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	1.5	-1.0	-1.2	0.6
Falls in the last year	1.2	1.6	2.7	1.6	1.5	0.2
Hair/balding pattern: Pattern 3	0.4	0.6	1.5	0.4	1.2	0.2
Number of live births	0.9	1.3	1.8	-1.3	-1.0	1.0
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	7.5	2.7	-0.4	0.2
Pulse rate	0.8	1.4	2.5	-1.6	-1.3	-0.4
Happiness	2.1	2.5	4.4	-1.1	-1.4	2.1
Noisy workplace	1.4	1.7	5.1	0.0	0.1	2.3
Qualifications: A levels/AS levels or equivalent	0.3	0.8	1.3	0.9	0.4	-1.2
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.4	-0.2	0.1	0.7
Mouth/teeth dental problems: Dentures	0.5	0.8	1.5	-0.5	1.2	-0.8
Asthma	0.7	1.4	4.2	-0.1	2.1	-0.0
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.6	-0.4	-0.8	-0.4
Medication: Cholesterol lowering	2.3	3.5	9.0	-1.3	0.1	3.0
Depression (self-reported)	0.4	0.4	1.2	0.1	-0.3	-1.1
Medication: Lansoprazole	0.3	0.3	0.6	0.5	-0.3	-0.7
Prospective memory result	2.1	2.6	4.3	-1.7	-0.9	2.1
Lung cancer (father)	0.4	0.4	1.2	0.2	-0.1	1.1
Illnesses of mother	0.1	0.1	0.2	-0.0	-0.4	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.1	3.2	1.8	-0.3	0.3
Pulse wave Arterial Stiffness index	0.3	0.4	1.0	0.0	-0.2	-1.0
Impedance of arm (left)	0.5	2.2	3.4	-0.8	1.6	-1.9
Arm fat mass (right)	1.1	4.5	13.4	-0.0	-3.7	-0.4
Trunk predicted mass	1.2	6.7	10.2	2.7	-3.2	-1.7
Standing height	1.2	12.0	16.6	3.7	-2.4	-4.1
Length of working week for main job	1.6	1.8	3.5	-0.5	-1.9	1.2
Exposure to tobacco smoke at home	1.7	1.9	2.7	1.2	-1.6	1.2
Breastfed as a baby	0.6	0.8	1.8	-1.3	0.1	0.7
Tense / ‘highly strung’	0.1	0.1	0.3	0.5	0.3	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	0.9	-0.9	0.4	1.0
Hair/balding pattern: Pattern 4	0.1	0.3	0.6	0.2	0.7	-0.5
Birth weight of first child	0.1	0.2	0.3	0.4	-0.1	-0.6
Peak expiratory flow (PEF)	0.6	1.4	3.0	1.7	0.8	-0.8
Pulse wave reflection index	0.4	0.4	1.0	-0.5	0.0	1.0
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.7	0.9	-1.3	0.2
Loud music exposure frequency	0.1	0.1	0.2	-0.4	0.3	0.4
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.3	-1.1	0.1	-0.9
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.3	-0.1	0.6	0.0
Blood clot in the leg (DVT)	1.5	2.0	5.2	-0.9	0.2	2.3
Medication: Paracetamol	0.8	1.3	3.9	0.4	-2.0	-0.0
Headache pain in last month	3.7	6.4	15.8	-0.1	-4.0	1.8
Medication for cholesterol, blood pressure or diabetes	1.1	1.9	5.1	0.7	0.0	-2.3
Glaucoma (self-reported)	0.9	1.1	2.2	1.5	1.0	-0.3
Gout (self-reported)	0.4	0.5	1.2	0.1	-0.4	-1.1
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	3.8	-1.9	-0.1	0.5
Medication: Amlodipine	0.6	0.9	1.2	0.9	1.1	0.7
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.9	-0.8	0.7	-1.7
Birth weight	0.4	0.9	1.2	0.9	1.1	-0.9
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	0.3	-0.6	0.3
High blood pressure (siblings)	0.8	1.1	2.5	-0.5	-0.7	1.6
Forced vital capacity (FVC), Best measure	0.4	1.4	2.5	1.6	-0.8	1.0
Body fat percentage	0.9	3.7	10.3	-0.9	-3.2	0.1
Leg fat percentage (right)	0.7	2.7	7.5	-0.4	-2.7	0.6
Arm fat-free mass (right)	1.2	6.0	13.5	2.1	-3.7	-0.2
Exposure to tobacco smoke outside home	0.5	0.6	1.2	-0.7	-1.1	0.3
Comparative body size at age 10	0.2	0.5	0.8	0.2	0.8	-0.9
Number of full brothers	0.4	0.5	1.1	-0.5	-1.1	0.2
Worry too long after embarrassment	0.4	0.7	1.2	-1.1	0.6	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.4	0.2	0.4	1.6
Wheeze or whistling in the chest in last year	0.8	1.4	1.6	-1.3	1.0	1.2
Number of children fathered	0.9	1.1	1.9	0.6	-1.4	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.7	-0.5	1.3	0.5
Age at first live birth	0.3	0.5	1.3	0.0	1.1	-0.6
Pulse wave peak to peak time	0.1	0.1	0.3	0.3	0.1	0.6
Health satisfaction	0.8	1.0	2.2	0.0	-1.5	0.9
Shortness of breath walking on level ground	0.4	0.5	0.5	0.6	-0.7	0.7
Qualifications: College or University degree	0.6	2.0	3.9	2.0	0.6	-1.3
Eye problems/disorders: None of the above	3.3	3.9	7.0	-1.7	-1.3	2.6
Mouth/teeth dental problems: Loose teeth	1.6	1.9	5.2	-0.2	0.6	2.3
Emphysema/chronic bronchitis	2.2	2.4	3.9	-1.8	-2.0	-0.4
Medication for pain relief, constipation, heartburn	0.7	1.1	2.7	0.3	1.6	-0.8
Neck or shoulder pain in last month	2.4	3.4	7.5	-1.2	-2.7	1.1
Medication: Blood pressure	0.8	1.5	4.2	-0.3	-0.5	2.0
Angina (self-reported)	2.5	3.3	7.8	-1.4	0.4	2.8
Migraine (self-reported)	1.7	2.2	4.9	0.9	-2.2	0.9
Medication: Ibuprofen	0.6	0.7	1.2	-0.6	-1.1	0.7
Medication: Allopurinol	0.4	0.6	1.5	0.1	-0.5	-1.2
Medication: Omeprazole	1.4	1.7	4.7	2.2	-0.0	0.7
Medication: Seretide 50 evohaler	0.4	0.4	0.6	-0.4	0.7	0.8
Mean time to correctly identify matches	1.4	2.6	5.9	-2.4	1.4	-0.2
Heart disease (mother)	1.0	1.3	2.1	-1.3	0.1	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.2	-1.1	0.4	0.4
Whole body fat mass	1.3	5.4	16.0	-0.1	-4.0	-0.2
Leg fat mass (right)	1.2	4.7	14.1	0.2	-3.8	0.1
Arm predicted mass (right)	1.1	5.5	12.7	1.9	-3.6	-0.1
Pulse rate, automated reading	0.6	1.9	3.1	-1.8	-0.2	-1.6
Alcohol intake frequency.	0.9	2.2	3.6	-0.2	-1.9	1.7
Comparative height size at age 10	0.8	4.6	9.9	3.1	-0.8	-1.8
Number of full sisters	0.5	0.6	0.8	-0.5	-0.8	0.9
Suffer from ‘nerves’	0.3	0.5	0.8	0.6	0.5	-0.9
Overall health rating	1.5	3.2	6.5	-1.4	-2.6	1.1
Chest pain or discomfort	0.6	0.9	2.4	-0.1	1.6	0.6
Had major operations	1.4	1.7	2.7	1.6	-1.6	-0.0
Age at last live birth	0.2	0.3	0.8	-0.9	-0.4	0.2
Family relationship satisfaction	0.8	1.0	1.5	-1.2	-0.9	0.7
Leg pain on walking	0.5	0.6	1.0	-1.0	0.8	-0.2
Qualifications: NVQ or HND or HNC or equivalent	2.7	3.2	4.2	-1.4	-1.8	2.1
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.4	-0.6	-1.2	0.8
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	1.3	0.8	-1.1	-1.0
Medication: Aspirin	1.0	1.3	2.0	-1.4	-0.7	1.1
Supplements: Vitamin C	0.0	0.0	0.0	0.2	-0.0	-0.0
Knee pain experienced in last month	0.7	1.0	2.5	-0.5	-1.6	0.6
Hypertension (Self-reported)	1.0	2.8	4.1	-1.4	1.5	2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.4	0.7	-0.6	-0.2
Illnesses of father: Heart disease	1.4	2.0	3.3	1.8	1.2	1.1
Illnesses of siblings: Diabetes	0.2	0.2	0.3	0.5	-0.6	-0.0
Smoking status: Previous	2.4	3.6	7.4	1.7	-2.7	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.2	1.1	-0.8	-0.7
Whole body fat-free mass	1.1	6.4	12.5	2.2	-3.5	-1.4
Leg fat-free mass (right)	0.9	5.0	12.0	1.4	-3.5	-1.1
Arm fat percentage (left)	0.9	3.4	8.6	-1.3	-2.9	0.1
Average weekly red wine intake	1.0	1.5	2.7	1.3	0.2	-1.7
Handedness (chirality/laterality): Left-handed	0.8	0.9	2.1	0.6	-0.6	1.4
Mood swings	0.3	0.5	0.9	0.2	-0.9	0.7
Loneliness, isolation	0.4	0.6	1.7	-1.3	0.3	0.1
Long-standing illness, disability or infirmity	0.6	1.0	2.1	1.4	0.7	0.6
Ever had bowel cancer screening	1.3	1.5	3.3	-0.6	-1.0	1.8
Diabetes diagnosed by doctor	0.2	0.3	1.0	0.1	0.1	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.6	-1.3	-0.0	0.6
Friendships satisfaction	1.1	1.3	1.9	-0.7	-1.4	1.3
Qualifications: nursing, teaching	2.0	3.0	6.5	0.7	1.5	-2.5
Commuting to job workplace: Walk	2.9	3.1	7.1	1.5	0.0	-2.7
Eye problems/disorders: Cataract	1.1	1.3	2.6	1.2	0.0	-1.6
Mouth/teeth dental problems: Mouth ulcers	1.5	2.4	6.5	2.5	0.0	-0.9
Medication for cholesterol	1.1	1.6	2.8	1.3	-0.7	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.0	0.7	-0.5	1.0
Back pain experienced in last month	0.5	0.7	1.6	-0.7	-1.3	0.4
Mineral and other dietary supplements	0.2	0.2	0.5	0.4	0.2	0.7
Breast cancer (self-reported)	2.3	2.7	6.7	-0.6	1.0	2.6
Asthma (self-reported)	0.8	1.5	4.5	-0.0	2.1	0.1
Osteoporosis (self-reported)	0.0	0.1	0.2	-0.0	0.4	-0.1
Osteoarthritis (self-reported)	0.9	1.2	2.9	0.4	-1.7	0.7
Medication: Aspirin	1.1	1.4	2.1	-1.2	-0.9	1.4
Medication: Gliclazide	1.3	1.5	3.1	0.3	1.2	-1.8
Illnesses of father: None of the above (group 1)	0.7	0.9	1.6	0.5	-0.8	-1.3
Smoking status: Current	0.0	0.1	0.1	-0.1	-0.3	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.4	2.1	0.8	1.1	1.4
Whole body water mass	1.0	6.0	12.5	2.0	-3.5	-1.2
Leg predicted mass (right)	1.0	5.3	12.3	1.5	-3.5	-1.2
Arm fat mass (left)	1.0	4.3	12.8	-0.2	-3.6	-0.1
Number of self-reported non-cancer illnesses	0.7	1.2	3.4	0.1	-0.3	1.8
Average weekly champagne plus white wine intake	0.9	1.3	2.4	-0.0	1.2	-1.6
Miserableness	0.1	0.1	0.3	0.1	-0.5	0.2
Guilty feelings	0.3	0.4	0.6	-0.7	-0.7	0.4
Wears glasses or contact lenses	1.0	1.2	1.8	-0.3	-1.4	-1.3
Ever taken oral contraceptive pill	0.3	0.3	0.6	0.8	0.5	-0.4
Hearing aid user	2.5	2.9	8.1	2.8	-0.6	-0.5
Mother’s age at death	1.6	2.0	3.9	1.1	0.9	-2.0
Financial situation satisfaction	0.5	0.6	0.7	-0.7	-0.8	-0.8
Tinnitus: Yes, now most or all of the time	3.1	3.6	7.5	2.7	1.8	-0.4
Commuting to job workplace: Public transport	0.2	0.3	0.4	-0.7	0.1	-0.6
Eye problems/disorders: Glaucoma	1.3	1.5	2.2	1.5	1.2	-1.0
Medication: Blood pressure	1.2	2.4	3.8	-1.9	1.6	0.8
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.9	0.0	-0.7	-0.9
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.0	-0.2	-0.2	-0.2
High cholesterol (Self-reported)	0.9	1.6	2.5	-1.6	0.1	1.5
Medication: Bendroflumethiazide	0.5	0.8	1.2	-1.1	1.1	0.2
Medication: Paracetamol	1.0	1.6	3.9	0.7	-2.0	0.5
Medication: Lisinopril	0.7	0.9	1.6	0.9	-0.5	1.3
Medication: Atorvastatin	0.8	0.9	2.6	-1.6	-0.0	0.4
Illnesses of father: High blood pressure	0.7	0.9	1.5	-1.0	-1.2	-0.2
Alcohol drinker status: Never	0.7	0.9	1.8	-0.5	-0.8	-1.4
Ever smoked	2.6	4.6	11.9	1.3	-3.4	0.5
Basal metabolic rate	1.1	6.3	13.2	2.0	-3.6	-1.3
Leg fat percentage (left)	0.8	2.7	7.5	-0.4	-2.7	0.7
Arm fat-free mass (left)	1.1	5.7	12.5	2.0	-3.5	-0.8
Number of operations (self-reported)	0.1	0.2	0.3	0.5	-0.3	0.5
Average weekly beer plus cider intake	0.2	0.3	0.7	-0.8	0.4	-0.0
Irritability	1.1	1.9	5.2	-0.7	-2.3	0.4
Risk taking	0.7	1.0	1.8	1.2	-1.3	-0.0
Ever had prostate specific antigen (PSA) test	0.8	0.9	1.9	0.5	-1.4	0.7
Fractured/broken bones in last 5 years	0.4	0.5	0.8	0.9	0.1	-0.7
Age started oral contraceptive pill	0.5	0.6	1.8	-0.3	-0.2	1.3
Diastolic blood pressure, automated reading	0.7	2.3	5.6	-1.0	-0.4	2.4
Ever depressed for a whole week	0.6	0.7	1.8	1.3	-0.6	0.1
Unable to work because of sickness or disability	0.7	0.9	1.9	-1.4	0.7	0.5
Commuting to job workplace: Cycle	1.4	1.7	4.0	2.0	0.5	-0.9
Myopia	0.7	1.0	2.3	-0.8	-1.5	-0.3
Vascular/heart problems diagnosed by doctor	1.9	5.2	9.2	1.8	-1.8	-3.0
Cholesterol lowering medication	1.0	1.4	2.9	-1.1	-0.4	1.7
Medication: Omeprazole (e.g. Zanprol)	2.0	2.4	6.5	2.6	0.7	0.3
Pain experienced in last month	0.7	1.2	3.6	-0.3	1.9	0.2
Supplements: Calcium	3.6	3.9	9.7	0.5	3.1	-1.3
Basal cell carcinoma (self-reported)	0.5	0.6	1.1	0.7	0.3	-1.1
Heart attack/myocardial infarction (self-reported)	2.2	2.9	7.8	0.0	-0.9	2.8
Deep venous thrombosis (DVT) (self-reported)	1.6	2.1	4.6	-1.1	0.6	2.1
Heart disease (siblings)	4.0	5.0	6.6	-1.5	-2.5	2.6
Alcohol drinker status: Previous	0.7	0.8	1.7	0.6	-1.3	0.4
Pack years of smoking	0.3	0.5	0.9	-1.0	-0.7	0.2
Impedance of whole body	0.3	1.7	3.2	-0.1	1.8	-1.4
Leg fat mass (left)	1.3	4.9	14.8	0.2	-3.8	0.1
Arm predicted mass (left)	1.1	5.8	11.4	2.4	-3.4	-0.7