Hub : Genes

GTF2E2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.0840	0.0330	1.6e-03	-0.004	NA	0.007	NA	0.000	8.4e-01	NA	8.7e-02	NA	3.1e-01
2	GTEx	Esophagus Muscularis	0.2380	0.0570	2.9e-07	0.072	NA	0.109	NA	0.095	3.8e-05	NA	3.9e-07	NA	2.2e-06
3	GTEx	Ovary	0.3210	0.0980	9.9e-04	0.186	NA	0.165	NA	0.173	2.6e-05	NA	7.6e-05	NA	5.0e-05
4	METSIM	Adipose	0.0914	0.0272	4.4e-06	0.046	0.040	0.047	0.050	0.054	1.8e-07	1.0e-06	1.3e-07	5.1e-08	1.4e-08
5	YFS	Blood	0.1017	0.0213	0.0e+00	0.083	0.075	0.087	0.083	0.087	9.7e-26	2.5e-23	4.8e-27	8.0e-26	4.2e-27
6	TCGA	Brain Lower Grade Glioma	0.0336	0.0204	8.3e-03	0.029	0.004	0.009	NA	0.012	2.5e-04	1.0e-01	3.1e-02	NA	1.3e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.8	1.3	2.5	0.8	-1.3	1.6	-1.0	-1.1	-0.6
Bipolar Disorder or Schizophrenia	0.1	0.1	0.2	0.1	-0.5	0.5	-0.2	-0.4	0.4
Depressed Affect (Nagel 2018)	0.0	0.0	0.1	-0.3	-0.2	-0.2	-0.2	0.2	-0.2
Depression (Nagel 2018)	0.3	0.5	1.2	-0.7	-0.0	-0.3	-1.0	-0.3	-1.1
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.3	-1.1	-0.5	0.1	-0.6	-0.6	-1.0
Neuroticism (Nagel 2018)	0.2	0.4	1.0	-0.5	-0.3	-0.2	-0.8	-0.3	-1.0
Schizophrenia (2018)	0.2	0.4	1.1	-0.6	0.5	-0.7	0.5	0.3	1.0
Schizophrenia vs Biploar Disorder	1.3	1.7	6.9	-0.5	2.6	-1.5	0.6	0.7	0.4
Worry (Nagel 2018)	0.2	0.5	1.3	-0.4	-1.1	0.7	-0.6	-0.9	-0.2
Alzheimer’s Disease (in mother)	2.2	2.6	4.8	1.0	-0.6	-1.4	2.1	2.2	1.7
Alzheimer’s Disease (in father)	0.9	1.0	1.6	-1.3	0.7	0.0	1.2	1.1	1.1
Alzheimer’s Disease (including proxy)	1.4	2.0	4.7	-0.6	0.1	-1.5	1.8	2.2	1.2
Crohns Disease (2017)	0.3	0.7	1.6	-0.5	-0.7	0.8	0.9	0.5	1.3
Irritable Bowel Disease (IBD)	0.1	0.3	0.6	0.0	-0.8	0.7	0.3	0.1	0.7
Ulcerative Colitis (UC)	0.3	0.5	1.1	1.0	-0.5	0.5	-0.9	-0.8	-0.3
Major Depression (MDD)	0.6	0.8	2.2	-0.3	1.4	-1.5	0.3	0.6	0.0
Reaction Time	0.5	1.0	2.5	-0.8	1.6	-0.9	1.1	0.7	0.6
Verbal and Numeric Reasoning (VNR)	0.4	1.0	3.3	-1.8	0.1	-0.5	-0.6	-0.2	-1.3
Breast Cancer	1.4	3.3	4.5	-2.1	-0.9	1.7	-2.1	-1.9	-2.0
Ovarian Cancer	0.6	0.8	1.8	-0.1	-0.1	0.6	-1.3	-1.3	-1.0
Prostate Cancer	1.0	1.4	5.8	2.4	0.9	0.6	-0.6	-1.0	0.1
Age at First Birth	0.2	0.3	1.1	1.1	0.1	0.2	0.1	-0.5	0.4
Bipolar Disorder (2011)	1.0	1.0	4.1	-2.0	-1.0	0.0	-0.4	-0.4	-0.7
Body Mass Index (BMI) (2010)	0.3	0.4	1.6	0.2	0.2	-0.2	-0.8	-0.5	-1.3
Coronary Artery Disease (CAD)	2.1	2.6	5.7	0.6	2.4	-2.0	1.3	1.7	0.9
Crohns Disease (2012)	0.3	0.5	1.6	-0.6	-1.0	1.3	0.2	-0.2	0.5
Mean Putamen Volume	2.0	2.3	4.0	1.3	-1.0	1.7	-1.7	-2.0	-1.2
Fasting Glucose	1.1	1.3	4.4	0.7	2.1	-1.5	0.2	0.4	-0.5
HbA1C	1.1	1.2	5.1	0.2	-2.3	1.2	-0.2	-0.7	0.5
HDL Cholesterol	0.3	0.4	1.3	-0.2	-1.0	1.2	0.2	-0.0	0.4
LDL Cholesterol	0.1	0.1	0.2	-0.0	-0.5	0.2	-0.3	0.4	-0.2
Lupus	0.4	0.6	1.2	0.9	0.0	0.8	-1.0	-1.1	-0.3
Neuroticism (2016)	2.3	3.3	11.2	-3.3	-1.1	1.3	-1.6	-1.4	-1.3
Primary Biliary Cirrhosis	0.1	0.2	0.3	0.5	0.0	0.5	0.4	0.3	0.5
Rheumatoid Arthritis	3.8	5.3	7.8	2.8	2.6	-2.1	2.0	1.8	2.4
Schizophrenia (2014)	0.1	0.2	0.5	-0.5	0.7	-0.5	0.0	-0.1	0.6
Triglycerides	0.2	0.3	0.5	0.7	-0.5	-0.5	0.5	0.6	0.3
Type 2 Diabetes (T2D) (2012)	0.4	0.5	0.8	-0.9	0.5	-0.2	-0.8	-0.4	-0.8
Ulcerative Colitis	0.1	0.2	0.7	-0.1	-0.1	0.3	-0.6	-0.8	-0.3
Blood Eosinophil Count	0.9	6.6	9.5	-3.1	-1.8	2.4	-2.7	-3.0	-2.2
Blood Platelet Count	2.1	24.7	31.7	-5.6	-5.3	4.6	-4.8	-4.3	-5.0
Blood Red Count	0.2	2.2	8.9	0.2	-3.0	1.8	0.3	-0.6	0.8
Blood White Count	0.8	6.3	22.8	-1.5	-4.8	3.4	-0.5	-0.8	-0.2
Heel T-Score	0.3	2.8	6.7	-2.6	-0.3	0.5	-1.7	-1.5	-2.2
BMI	0.1	0.6	1.3	1.1	1.1	-0.6	0.3	0.8	0.5
Height	1.8	35.4	81.2	-3.1	-9.0	8.4	-4.2	-4.8	-3.1
Waist Hip Ratio (WHR)	0.4	2.0	4.0	-0.3	-1.8	-1.5	1.4	2.0	0.5
Systolic Blood Pressure	0.8	3.9	7.6	2.7	-1.8	1.9	0.7	-1.0	2.7
Smoking Status	0.3	0.8	1.9	-1.0	0.3	-1.0	0.9	1.4	0.4
Allergy or Eczema	0.6	1.6	3.2	1.6	1.8	-1.5	0.8	0.8	0.8
Cardiovascular Disease	1.1	3.7	7.1	2.5	1.1	-1.2	1.8	1.6	2.7
Hypothyroidism (self reported)	0.4	1.0	2.6	0.5	0.6	-0.9	1.3	0.7	1.6
Respiratory disease	0.3	0.6	1.3	0.4	0.4	0.7	-1.1	-0.9	-0.9
Type 2 Diabetes (T2D) (2018)	0.3	0.6	2.0	-1.0	-0.4	-0.3	0.6	1.4	0.3
Lung FEV1/FVC ratio	0.1	0.5	1.3	0.9	-1.1	-0.6	-0.0	0.6	-0.4
Lung FVC	1.5	7.5	18.3	1.0	1.7	-1.7	3.6	2.6	4.3
Neuroticism	0.0	0.1	0.3	-0.1	0.0	-0.5	-0.4	0.0	-0.4
Chronotype (morning person)	0.3	0.6	2.2	-1.5	-0.9	-0.4	-0.1	0.2	-0.8
Hair Pigment	0.1	2.1	4.2	2.1	-0.8	0.1	1.5	1.6	1.6
Tanning	0.1	1.0	2.2	-0.8	-0.5	-0.0	-1.3	-1.1	-1.5
Hand grip strength (left)	1.1	2.9	8.7	0.6	-2.9	2.4	-0.7	-1.5	-0.2
Number of treatments/medications taken	3.1	5.6	8.6	1.1	1.9	-2.9	2.6	2.9	2.2
Average weekly spirits intake	1.1	1.4	6.0	-0.3	-2.5	0.6	-0.7	-0.5	-0.9
Sensitivity / hurt feelings	0.6	1.1	3.1	-1.1	0.1	-1.8	0.3	1.2	-0.7
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.6	-1.6	-0.2	-0.4	-1.1	-0.5	-1.4
Hearing difficulty/problems: Yes	0.4	0.6	1.6	-0.1	-0.2	1.1	-0.7	-1.3	-0.3
Relative age of first facial hair	0.3	0.7	2.3	1.5	0.0	-0.3	0.7	0.6	0.8
Other serious medical condition/disability diagnosed by doctor	3.7	4.8	8.6	0.7	1.2	-2.9	2.5	2.9	1.9
Ever used hormone-replacement therapy (HRT)	1.2	1.6	2.6	1.3	0.6	-1.6	1.4	1.3	1.0
Ever had hysterectomy (womb removed)	2.5	2.8	6.4	2.5	0.9	-1.4	1.6	1.2	1.9
Systolic blood pressure, automated reading	0.6	1.7	5.2	2.3	-0.5	1.2	-0.1	-1.0	1.4
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.8	-1.0	0.1	0.8	-1.2	-1.4	-1.2
Angina	4.0	5.3	12.3	3.5	1.7	-0.9	2.1	1.8	2.8
Medication for hormone replacement therapy	3.7	4.1	6.3	-0.1	2.3	-2.5	2.2	2.5	1.6
Vitamin and mineral supplements	0.2	0.3	0.9	1.0	0.3	-0.0	0.0	0.7	0.0
Supplements: Zinc	1.4	1.5	5.5	-0.5	-2.3	1.7	-0.3	-0.6	0.1
Medication: Co-codamol	0.4	0.5	0.8	-0.7	-0.9	-0.6	-0.4	0.6	-0.9
Medication: Metformin	0.4	0.5	1.4	-0.4	0.7	-0.4	0.8	1.2	0.6
Diabetes (father)	0.7	0.9	3.5	1.9	-0.8	0.9	-0.2	-0.3	0.3
Diabetes (mother)	0.6	0.7	1.8	-1.3	-0.7	-0.5	-0.8	-0.4	-1.0
Severe depression (siblings)	0.6	0.6	1.7	1.3	0.3	-0.8	0.7	0.8	0.3
Pack years adult smoking proportion	0.5	0.8	1.7	1.3	0.6	-0.1	1.0	0.7	1.2
Impedance of leg (right)	0.1	0.5	1.3	0.1	-0.2	0.5	-0.8	-1.1	-0.8
Leg fat-free mass (left)	0.3	1.8	6.4	0.2	-2.5	2.0	-0.3	-0.2	0.1
Trunk fat percentage	0.1	0.6	1.7	1.3	0.2	0.3	0.6	0.7	0.8
Hand grip strength (right)	0.7	1.8	5.4	-0.7	-2.3	1.8	-0.6	-1.1	-0.3
Townsend deprivation index at recruitment	1.2	1.6	4.2	0.6	-0.7	0.2	1.6	1.4	2.1
Current tobacco smoking	0.9	1.4	3.7	-0.7	0.9	-1.6	0.8	1.9	-0.1
Average weekly fortified wine intake	0.8	1.0	2.1	-1.5	0.5	0.0	-1.2	-0.8	-1.2
Maternal smoking around birth	0.2	0.2	0.9	0.5	-0.9	0.4	-0.3	-0.3	-0.2
Fed-up feelings	0.0	0.1	0.3	-0.5	0.1	-0.1	0.1	0.3	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	3.3	-0.6	1.6	-1.8	0.9	1.5	0.8
Relative age voice broke	0.1	0.2	0.4	-0.2	-0.3	0.0	0.6	0.6	0.6
Taking other prescription medications	2.3	3.6	5.5	1.1	1.9	-2.3	1.9	2.3	1.5
Age when periods started (menarche)	0.7	1.7	3.3	0.8	-1.8	1.6	-0.9	-1.6	0.2
Bilateral oophorectomy (both ovaries removed)	3.5	4.1	5.7	1.1	1.6	-2.2	2.4	2.2	2.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.2	0.1	-0.1	0.8	-0.6	-1.1	-0.4
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	3.4	-1.1	-0.3	-0.1	-1.4	-0.9	-1.8
Qualifications: CSEs or equivalent	0.6	0.8	1.2	1.1	0.4	-0.7	1.0	0.9	1.1
Serious illness, injury or assault to yourself	3.6	4.4	7.5	1.6	1.6	-2.7	2.2	2.4	1.7
High blood pressure	1.3	3.6	6.4	2.5	1.6	-1.4	1.7	1.8	2.2
Hayfever, allergic rhinitis or eczema	0.5	1.2	2.6	1.6	1.4	-0.8	0.8	0.1	1.0
Multivitamins +/- minerals	0.2	0.3	0.6	-0.8	-0.0	-0.2	-0.4	-0.7	-0.5
Stomach or abdominal pain in last month	6.7	8.3	10.4	2.1	2.9	-3.2	3.0	3.1	2.8
Supplements: Glucosamine	1.2	1.6	2.6	-1.0	-1.4	0.6	-1.4	-1.3	-1.6
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.4	0.2	-0.6	0.0	-0.4	-0.2	-0.7
Medication: Atenolol	2.1	2.6	6.5	1.6	-0.2	-0.1	1.9	1.6	2.5
Medication: Levothyroxine sodium	0.1	0.1	0.5	-0.3	0.0	-0.7	0.2	0.3	-0.1
Sitting height	1.3	9.5	26.0	-0.1	-5.1	4.6	-1.9	-2.5	-0.7
Chronic bronchitis/emphysema (father)	1.1	1.3	2.9	-0.1	0.4	0.4	-1.7	-1.5	-1.5
High blood pressure (mother)	0.6	0.8	2.2	1.5	-0.5	0.9	0.1	-0.5	1.1
Body mass index (BMI)	0.5	2.3	4.4	1.3	1.1	-1.3	1.6	2.1	1.5
Impedance of leg (left)	0.0	0.1	0.4	0.0	-0.3	0.5	0.0	-0.6	0.1
Leg predicted mass (left)	0.3	1.7	6.1	0.3	-2.5	2.0	-0.2	-0.1	0.2
Trunk fat mass	0.1	0.6	1.6	1.2	-0.8	1.0	0.3	0.4	0.6
Waist circumference	0.3	1.2	3.2	0.1	-1.0	-0.2	1.3	1.8	1.1
Number of incorrect matches in round	1.2	2.0	5.3	-2.3	1.4	-1.7	0.7	1.2	-0.4
Past tobacco smoking	0.3	0.6	2.3	0.1	1.5	-0.8	-0.3	-0.2	-0.6
Alcohol usually taken with meals	0.1	0.1	0.3	-0.5	0.1	0.5	-0.2	0.3	-0.0
Nervous feelings	0.7	1.3	3.1	0.2	-0.2	-0.8	1.5	1.3	1.8
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.1	-0.1	-0.2	-0.2	-0.1	0.3	-0.1
Hearing difficulty/problems with background noise	0.4	0.6	1.3	0.4	-0.9	0.9	0.5	-0.4	1.1
Hair/balding pattern: Pattern 2	1.1	1.5	8.2	2.9	-0.1	0.2	0.2	0.0	0.6
Had menopause	0.8	1.1	4.0	2.0	0.8	-0.7	0.6	0.2	0.8
Had other major operations	2.4	2.9	4.7	0.3	2.0	-2.2	1.7	2.1	1.2
Forced vital capacity (FVC)	0.4	1.6	3.9	0.8	-1.4	1.3	1.1	-0.0	2.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.9	0.3	-0.0	0.5	-0.7	-0.9	-0.5
Ever unenthusiastic/disinterested for a whole week	1.3	1.5	2.9	1.5	0.9	-0.9	1.4	0.9	1.7
Qualifications: None of the above	0.8	1.8	3.4	0.5	0.5	-0.8	1.7	1.8	1.8
Financial difficulties in last 2 years	0.8	1.1	2.3	-0.3	1.3	-1.0	1.0	1.5	0.8
Mouth/teeth dental problems	0.4	0.5	1.1	1.0	-0.5	0.9	0.5	-0.1	1.0
Heart attack	3.3	4.2	8.6	1.5	1.7	-0.9	2.3	2.3	2.9
Allergy	0.6	1.4	5.7	-2.4	-1.3	0.8	-0.1	0.3	-0.5
Pain all over the body in last month	1.2	1.3	3.5	-1.9	-1.0	0.8	-1.0	-1.0	-0.9
Diabetes (self-reported)	0.1	0.2	0.6	-0.3	0.8	-0.1	0.1	0.7	0.1
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	2.4	-1.0	-0.8	1.5	-1.1	-1.1	-0.4
Medication: Ramipril	1.7	2.1	4.8	-1.6	0.3	-1.0	1.7	2.2	1.2
Medication: Simvastatin	3.4	5.0	7.6	1.1	2.7	-2.7	2.0	2.8	1.6
Fluid intelligence score	0.6	1.2	5.2	-2.3	0.3	-0.3	-0.5	-0.3	-1.1
Illnesses of siblings	2.5	3.5	14.9	-3.9	-0.6	0.2	-1.2	-0.9	-1.9
Neuroticism score	0.2	0.5	1.8	-1.4	-0.1	-0.8	0.1	0.5	-0.2
Weight	0.2	1.1	3.7	0.7	-1.9	1.4	0.2	0.4	0.5
Impedance of arm (right)	0.7	3.1	5.8	-0.9	-1.2	2.2	-1.7	-2.4	-1.6
Arm fat percentage (right)	0.1	0.3	1.1	1.0	0.4	0.2	0.3	0.5	0.4
Trunk fat-free mass	0.7	3.9	12.9	-0.6	-3.6	2.8	-1.0	-0.7	-0.6
Hip circumference	0.2	0.9	3.6	0.8	-1.0	1.9	0.1	-0.0	0.7
Time employed in main current job	2.3	2.6	4.9	-0.5	-0.8	1.2	-2.2	-1.9	-2.2
Alcohol intake versus 10 years previously	1.3	2.0	3.9	-2.0	0.3	-0.7	1.8	1.4	1.6
Father’s age at death	1.1	1.4	3.4	-0.1	-1.7	1.8	-0.9	-0.7	-0.9
Worrier / anxious feelings	0.7	1.4	2.8	-0.3	-1.7	1.4	-0.9	-1.6	-0.5
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	3.9	-1.3	1.4	-1.2	1.7	2.0	1.6
Falls in the last year	0.5	0.7	3.6	1.9	0.0	-0.6	-0.1	0.3	-0.4
Hair/balding pattern: Pattern 3	0.4	0.6	1.2	-0.8	0.3	-0.3	-1.1	-0.7	-1.1
Number of live births	1.3	1.9	2.8	1.1	1.2	-1.3	1.7	1.5	1.3
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	5.3	0.6	-2.3	1.6	0.8	-0.3	1.6
Pulse rate	0.2	0.3	0.7	-0.2	0.3	-0.8	0.7	0.8	-0.1
Happiness	0.6	0.7	1.8	0.8	-0.3	-0.3	1.1	0.5	1.4
Noisy workplace	1.6	1.9	3.8	1.6	1.5	-0.6	1.5	0.6	1.9
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.6	-0.2	-0.5	0.5	-0.5	-0.8	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	3.1	-1.0	1.1	-1.8	-0.1	0.4	-0.7
Mouth/teeth dental problems: Dentures	0.2	0.4	0.9	0.7	1.0	-0.6	-0.2	0.2	-0.7
Asthma	0.3	0.7	1.6	0.7	0.7	-0.6	-0.9	-0.5	-1.3
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	3.3	-0.7	-0.0	-0.2	1.5	1.8	1.4
Medication: Cholesterol lowering	3.6	5.6	7.5	1.7	2.7	-2.1	2.4	2.3	2.7
Depression (self-reported)	1.0	1.1	2.7	-1.6	-0.8	-0.6	-0.9	0.0	-1.6
Medication: Lansoprazole	0.2	0.2	0.6	-0.1	0.3	-0.6	0.4	0.8	-0.2
Prospective memory result	1.5	1.8	2.6	1.5	1.6	-1.1	1.3	0.9	1.5
Lung cancer (father)	0.2	0.3	0.7	0.4	0.6	-0.8	0.4	0.2	0.5
Illnesses of mother	1.0	1.2	4.7	-0.5	2.2	-1.1	-0.2	-0.1	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	5.6	0.9	-1.2	0.9	1.7	0.7	2.4
Pulse wave Arterial Stiffness index	0.3	0.3	0.6	-0.6	0.6	-0.8	-0.1	0.3	-0.7
Impedance of arm (left)	0.6	2.8	6.5	-0.8	-0.6	1.8	-1.9	-2.5	-1.6
Arm fat mass (right)	0.1	0.4	0.8	0.9	-0.5	0.6	0.3	0.6	0.5
Trunk predicted mass	0.7	3.7	12.3	-0.6	-3.5	2.8	-1.0	-0.7	-0.6
Standing height	1.9	18.7	45.2	-1.2	-6.7	6.1	-3.1	-3.7	-2.2
Length of working week for main job	0.5	0.6	2.6	1.6	0.4	-0.0	0.5	0.2	0.7
Exposure to tobacco smoke at home	1.4	1.6	2.2	1.4	0.7	-1.2	1.4	1.5	1.3
Breastfed as a baby	0.7	0.8	2.0	1.4	1.1	-0.2	0.7	0.5	0.8
Tense / ‘highly strung’	0.7	1.1	2.6	-0.8	-0.6	-1.2	1.1	1.6	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	2.7	-0.2	1.2	-1.6	0.8	1.6	0.4
Hair/balding pattern: Pattern 4	0.1	0.3	1.0	-1.0	-0.6	-0.5	-0.0	0.0	-0.3
Birth weight of first child	1.2	2.1	4.3	-0.9	-1.1	2.1	-1.4	-1.9	-0.8
Peak expiratory flow (PEF)	0.3	0.7	1.7	-0.9	-1.3	1.0	0.4	-0.3	0.6
Pulse wave reflection index	0.3	0.3	0.9	1.0	-0.2	-0.0	0.4	0.2	0.9
Ever highly irritable/argumentative for 2 days	0.6	0.8	1.6	0.2	-0.4	-0.5	1.2	1.3	1.1
Loud music exposure frequency	0.8	0.8	2.2	1.0	0.1	0.2	1.2	0.6	1.5
Qualifications: O levels/GCSEs or equivalent	1.3	2.0	4.6	-0.7	0.0	1.6	-1.8	-2.1	-1.3
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.5	-1.6	0.6	-1.0	0.1	0.3	-0.4
Blood clot in the leg (DVT)	1.7	2.3	9.5	3.1	0.3	-0.8	0.9	0.8	1.4
Medication: Paracetamol	1.1	1.7	4.5	0.9	-1.3	0.7	1.5	0.9	2.1
Headache pain in last month	1.4	2.4	6.0	2.5	-0.8	-0.2	1.6	1.1	1.9
Medication for cholesterol, blood pressure or diabetes	1.7	2.8	4.5	-1.6	-1.2	1.3	-1.8	-1.8	-2.1
Glaucoma (self-reported)	3.0	3.5	7.4	-2.2	1.6	-1.4	-1.6	-1.1	-2.7
Gout (self-reported)	1.1	1.5	2.0	-1.1	-1.3	1.4	-1.1	-1.3	-1.0
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.9	-0.3	-0.1	-0.9	0.8	0.5	0.6
Medication: Amlodipine	1.1	1.5	3.3	-1.3	1.6	-1.8	0.3	1.0	-0.3
Medication: Ventolin 100micrograms inhaler	2.4	3.1	5.0	-0.1	-1.1	1.6	-2.2	-2.1	-2.2
Birth weight	0.4	0.8	1.6	-0.4	-0.1	0.6	-1.3	-0.9	-1.3
Chronic bronchitis/emphysema (mother)	1.1	1.3	3.8	-0.2	1.6	-2.0	0.1	0.8	-0.7
High blood pressure (siblings)	1.6	2.4	7.8	2.8	-0.3	-0.1	1.3	0.8	2.0
Forced vital capacity (FVC), Best measure	0.7	2.4	7.5	1.1	-0.9	0.8	1.9	0.8	2.7
Body fat percentage	0.2	0.7	1.9	1.4	0.6	-0.1	0.7	0.9	0.8
Leg fat percentage (right)	0.5	1.6	2.8	1.7	1.4	-1.2	0.9	1.5	0.7
Arm fat-free mass (right)	0.2	1.3	4.5	0.3	-2.1	1.5	0.3	0.5	0.7
Exposure to tobacco smoke outside home	0.2	0.3	0.9	0.9	-0.7	0.3	0.1	-0.3	0.3
Comparative body size at age 10	0.3	0.8	1.5	0.1	-1.1	0.7	-0.9	-1.2	-0.8
Number of full brothers	0.4	0.5	1.1	0.7	-0.1	0.0	1.0	0.6	1.0
Worry too long after embarrassment	0.3	0.6	2.7	-1.7	0.1	-0.6	-0.2	0.1	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	5.7	0.3	0.8	-2.4	1.3	2.0	0.7
Wheeze or whistling in the chest in last year	1.0	1.9	3.6	1.8	1.9	-1.8	0.5	0.8	0.0
Number of children fathered	1.2	1.4	3.2	-0.1	0.2	0.7	-1.8	-1.4	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.1	-0.7	1.0	-0.6	0.3	0.1	0.3
Age at first live birth	2.3	4.0	8.3	0.4	-1.7	2.9	-2.1	-2.8	-0.8
Pulse wave peak to peak time	0.6	0.7	1.8	0.4	-1.2	1.3	-0.2	-0.6	0.5
Health satisfaction	0.4	0.6	1.0	0.9	-0.4	-0.1	0.9	1.0	0.9
Shortness of breath walking on level ground	0.7	0.8	3.3	1.8	0.3	-0.5	0.5	0.9	0.2
Qualifications: College or University degree	0.4	1.2	2.7	-1.4	-0.6	0.5	-1.2	-0.7	-1.6
Eye problems/disorders: None of the above	6.9	7.9	16.2	4.0	0.6	-0.8	3.1	2.4	3.9
Mouth/teeth dental problems: Loose teeth	1.2	1.4	4.8	0.9	2.2	-1.7	-0.1	0.0	0.2
Emphysema/chronic bronchitis	0.6	0.7	2.7	0.6	-0.4	1.6	-0.6	-0.6	0.1
Medication for pain relief, constipation, heartburn	2.1	3.6	7.7	-0.2	-0.2	0.8	-2.6	-2.5	-2.8
Neck or shoulder pain in last month	2.7	3.9	7.5	0.7	1.0	-2.5	2.3	2.7	1.6
Medication: Blood pressure	1.6	2.8	4.5	1.4	1.4	-1.3	1.9	1.8	2.1
Angina (self-reported)	4.0	5.3	13.3	3.6	1.5	-0.8	2.1	1.7	2.9
Migraine (self-reported)	0.4	0.6	1.8	1.4	-0.4	-0.5	0.5	0.8	0.4
Medication: Ibuprofen	1.5	1.8	4.0	0.5	0.7	-0.5	1.7	2.0	1.8
Medication: Allopurinol	0.9	1.2	2.0	-1.0	-1.4	1.3	-0.8	-0.9	-0.8
Medication: Omeprazole	0.9	1.0	2.4	-0.9	1.4	-1.6	0.7	0.7	0.2
Medication: Seretide 50 evohaler	0.9	1.0	3.1	1.0	1.8	-1.2	-0.3	-0.1	-0.5
Mean time to correctly identify matches	0.4	0.8	2.7	-0.9	1.6	-0.9	0.5	0.6	0.1
Heart disease (mother)	0.3	0.3	0.9	0.9	-0.1	0.0	0.3	0.2	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.0	-0.3	0.3	-1.0	0.8	0.8	0.6
Whole body fat mass	0.1	0.6	1.6	1.3	-0.5	0.8	0.4	0.6	0.8
Leg fat mass (right)	0.2	0.8	2.3	1.5	0.1	-0.1	0.7	1.2	0.8
Arm predicted mass (right)	0.2	1.1	3.3	0.4	-1.8	1.3	0.4	0.7	0.8
Pulse rate, automated reading	0.2	0.7	2.3	-1.1	0.2	-0.5	-0.6	0.3	-1.5
Alcohol intake frequency.	1.3	2.9	6.5	0.6	0.1	-0.5	2.4	2.2	2.6
Comparative height size at age 10	1.0	5.5	14.8	0.0	-3.9	2.6	-2.1	-1.8	-2.0
Number of full sisters	2.1	2.5	4.8	1.3	1.3	-1.7	1.5	2.2	1.4
Suffer from ‘nerves’	0.4	0.6	2.8	-1.7	-0.5	-0.1	-0.1	0.5	-0.1
Overall health rating	1.3	2.7	5.3	1.3	-0.2	-0.5	2.0	2.3	2.3
Chest pain or discomfort	1.3	1.9	3.7	0.4	1.0	-1.5	1.6	1.9	1.3
Had major operations	1.1	1.3	2.5	-0.5	-0.3	-0.8	1.6	1.5	1.3
Age at last live birth	1.5	2.2	5.3	1.0	-0.7	2.2	-1.3	-2.3	-0.2
Family relationship satisfaction	0.4	0.5	1.3	1.2	-0.1	-0.2	0.7	0.5	1.0
Leg pain on walking	0.3	0.3	1.1	-0.2	0.5	-0.6	0.4	1.0	-0.3
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.0	7.4	2.7	1.1	-0.0	1.1	0.4	1.5
Commuting to job workplace: Car/motor vehicle	0.5	0.6	2.1	-0.2	1.5	-0.8	0.5	0.6	0.3
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	4.5	0.1	-2.1	2.1	0.0	-0.4	0.8
Medication: Aspirin	1.0	1.3	1.7	0.9	1.3	-1.1	1.1	1.1	1.3
Supplements: Vitamin C	0.3	0.3	0.8	-0.9	-0.5	-0.1	0.7	0.1	0.6
Knee pain experienced in last month	0.5	0.8	2.4	0.8	-0.5	0.7	1.0	0.5	1.6
Hypertension (Self-reported)	1.1	3.1	7.4	2.7	1.2	-1.2	1.4	1.5	1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.8	5.5	-0.7	0.7	-0.7	-1.5	-1.2	-2.3
Illnesses of father: Heart disease	2.2	3.0	6.4	0.1	0.1	-2.4	2.1	2.5	1.2
Illnesses of siblings: Diabetes	0.3	0.3	1.1	1.0	0.1	-0.1	0.5	0.7	0.4
Smoking status: Previous	0.3	0.5	1.5	0.1	-0.6	0.7	0.6	-0.0	1.2
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.0	5.4	-1.1	-2.3	2.0	0.2	-1.0	0.6
Whole body fat-free mass	0.5	2.8	10.2	-0.3	-3.2	2.5	-0.4	-0.2	-0.0
Leg fat-free mass (right)	0.4	2.0	7.3	0.1	-2.7	2.0	0.1	0.1	0.5
Arm fat percentage (left)	0.1	0.5	1.2	1.1	0.9	-0.2	0.3	0.6	0.4
Average weekly red wine intake	1.6	2.4	6.4	-2.5	-0.8	0.6	-1.5	-1.1	-1.8
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.0	0.5	0.6	0.5	0.2	-0.8	1.4
Mood swings	0.8	1.4	3.4	-1.8	0.0	-1.3	0.9	1.6	0.5
Loneliness, isolation	0.6	0.9	2.0	-1.4	0.6	-1.1	0.5	1.2	0.0
Long-standing illness, disability or infirmity	2.6	4.0	9.0	-0.5	1.6	-3.0	1.9	2.8	0.8
Ever had bowel cancer screening	2.7	3.1	6.0	0.6	2.2	-2.5	1.5	2.1	0.8
Diabetes diagnosed by doctor	0.3	0.5	1.3	-0.7	0.1	-0.3	0.7	1.2	0.7
Ever had stillbirth, spontaneous miscarriage or termination	2.7	2.9	6.0	0.4	1.0	-1.5	2.5	2.1	1.9
Friendships satisfaction	0.2	0.2	0.5	-0.0	0.1	-0.7	0.7	0.3	0.5
Qualifications: nursing, teaching	2.0	3.2	5.5	-0.9	-2.2	2.3	-1.6	-1.9	-1.4
Commuting to job workplace: Walk	2.6	2.8	7.6	0.7	-2.8	2.7	-0.8	-0.7	-0.3
Eye problems/disorders: Cataract	2.4	2.8	7.7	-2.8	-0.4	0.9	-1.8	-1.4	-1.7
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	6.6	-2.6	-1.1	0.8	-1.3	-1.0	-1.3
Medication for cholesterol	4.1	6.2	10.8	-1.4	-2.8	3.1	-2.3	-3.3	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	2.3	0.4	0.2	-0.8	1.4	1.5	1.3
Back pain experienced in last month	0.6	0.9	1.8	-0.3	1.2	-1.3	0.8	1.1	0.2
Mineral and other dietary supplements	0.6	0.8	1.6	1.0	1.3	-1.1	0.5	0.7	0.1
Breast cancer (self-reported)	2.4	2.9	7.1	1.2	2.7	-2.6	0.7	1.0	0.1
Asthma (self-reported)	0.3	0.6	1.3	0.6	1.1	-0.9	-0.4	-0.1	-0.9
Osteoporosis (self-reported)	0.5	0.6	1.7	1.1	0.3	-1.3	-0.2	0.2	-0.8
Osteoarthritis (self-reported)	2.4	3.1	5.2	1.5	0.6	-1.9	2.1	2.3	1.7
Medication: Aspirin	1.2	1.6	2.9	0.9	1.7	-1.2	1.1	1.1	1.3
Medication: Gliclazide	2.1	2.4	4.5	-0.9	-1.3	1.4	-1.8	-2.1	-1.6
Illnesses of father: None of the above (group 1)	1.4	1.7	3.6	-0.4	-1.8	1.9	-1.0	-1.4	-0.6
Smoking status: Current	0.6	0.9	2.3	-1.2	0.4	-1.1	0.3	1.5	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	3.7	0.6	0.2	-0.3	1.1	0.2	1.9
Whole body water mass	0.5	2.6	9.4	-0.2	-3.1	2.5	-0.4	-0.2	0.0
Leg predicted mass (right)	0.4	2.0	7.7	-0.0	-2.8	2.1	0.0	0.0	0.4
Arm fat mass (left)	0.1	0.4	1.1	1.0	-0.2	0.3	0.4	0.7	0.6
Number of self-reported non-cancer illnesses	1.7	2.9	4.7	1.9	-0.0	-1.4	1.9	2.0	2.2
Average weekly champagne plus white wine intake	2.8	3.9	6.4	-2.1	-1.1	1.5	-2.4	-1.9	-2.5
Miserableness	0.9	1.5	3.7	-1.9	0.8	-1.4	0.7	1.5	0.2
Guilty feelings	0.8	1.2	2.3	-0.9	0.6	0.1	-1.4	-1.5	-1.3
Wears glasses or contact lenses	2.4	2.8	3.9	1.5	-2.0	1.9	-1.5	-1.7	-1.3
Ever taken oral contraceptive pill	0.0	0.0	0.1	-0.1	-0.2	0.0	0.1	-0.3	-0.3
Hearing aid user	0.8	0.9	2.0	-0.2	-1.4	1.3	-0.5	-1.1	-0.1
Mother’s age at death	3.5	4.3	9.5	-2.8	-0.6	0.4	-2.5	-1.5	-3.1
Financial situation satisfaction	1.0	1.2	3.4	-1.9	-1.2	1.4	-0.6	-0.7	-0.1
Tinnitus: Yes, now most or all of the time	1.4	1.6	4.3	-2.1	-0.1	-0.2	-1.2	-1.0	-1.8
Commuting to job workplace: Public transport	0.4	0.5	1.8	-0.2	-0.3	1.3	-0.7	-0.7	-0.4
Eye problems/disorders: Glaucoma	3.8	4.5	11.2	-2.3	1.6	-1.0	-2.2	-1.4	-3.3
Medication: Blood pressure	0.8	1.6	3.0	1.7	1.7	-1.3	0.6	1.3	0.4
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.1	-0.8	-0.6	0.2	0.9	0.8	1.1
Supplements: Fish oil (including cod liver oil)	0.4	0.5	2.2	0.4	-1.5	0.7	0.2	-0.2	0.5
High cholesterol (Self-reported)	1.3	2.4	3.7	1.5	1.9	-1.7	1.3	1.6	1.1
Medication: Bendroflumethiazide	1.1	1.7	5.5	0.3	2.4	-1.8	0.0	1.0	-0.8
Medication: Paracetamol	1.2	1.8	5.2	1.1	-0.6	0.4	1.7	1.1	2.3
Medication: Lisinopril	0.7	0.9	4.2	2.1	0.1	0.2	-0.3	-0.9	0.2
Medication: Atorvastatin	0.3	0.4	1.2	1.1	-0.3	0.5	0.2	0.3	0.7
Illnesses of father: High blood pressure	0.2	0.2	0.8	-0.1	-0.1	0.9	0.1	-0.4	0.4
Alcohol drinker status: Never	0.5	0.6	1.9	-0.4	-1.4	1.0	0.3	0.0	0.2
Ever smoked	0.1	0.3	0.8	-0.2	-0.9	0.0	0.4	0.6	0.3
Basal metabolic rate	0.4	2.4	8.8	-0.1	-3.0	2.3	-0.3	-0.1	0.1
Leg fat percentage (left)	0.5	1.9	3.0	1.5	1.3	-1.3	1.3	1.7	1.1
Arm fat-free mass (left)	0.3	1.5	5.5	-0.3	-2.3	1.5	0.4	0.7	0.6
Number of operations (self-reported)	1.6	2.3	6.0	0.5	0.5	-2.2	1.5	2.4	0.7
Average weekly beer plus cider intake	0.1	0.1	0.2	0.1	0.1	0.3	-0.3	-0.5	0.1
Irritability	0.5	0.9	2.0	-1.4	1.0	-1.1	0.5	0.9	-0.0
Risk taking	0.5	0.7	2.7	-1.6	0.0	-0.5	0.1	0.9	-0.4
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.1	1.0	-0.1	-0.3	-1.0	-0.5	-1.1
Fractured/broken bones in last 5 years	0.3	0.4	1.4	-0.7	-0.1	-0.2	-0.7	-0.5	-1.2
Age started oral contraceptive pill	0.6	0.7	3.2	1.8	-0.2	0.7	0.4	-0.1	0.6
Diastolic blood pressure, automated reading	1.2	3.7	12.2	3.5	0.8	-0.0	1.4	0.3	2.7
Ever depressed for a whole week	0.3	0.4	0.6	-0.8	-0.5	0.6	0.3	-0.5	0.8
Unable to work because of sickness or disability	0.9	1.2	2.3	-0.3	0.5	-1.5	1.2	1.5	0.9
Commuting to job workplace: Cycle	0.9	1.0	4.3	-2.1	-1.0	-0.3	-0.6	-0.4	-0.7
Myopia	0.4	0.6	1.2	0.6	0.6	-0.4	1.0	1.1	0.8
Vascular/heart problems diagnosed by doctor	2.2	5.9	9.5	-3.1	-2.4	1.6	-2.2	-2.1	-2.9
Cholesterol lowering medication	3.1	4.6	7.7	1.6	2.4	-2.8	1.8	2.7	1.0
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.9	-1.4	1.2	-1.2	0.3	0.5	-0.2
Pain experienced in last month	0.3	0.6	1.0	0.7	0.6	0.8	-0.9	-1.0	-0.5
Supplements: Calcium	1.1	1.2	5.3	-2.3	-0.7	-0.7	0.2	0.6	-0.6
Basal cell carcinoma (self-reported)	1.3	1.6	2.9	-0.9	-1.1	1.0	-1.7	-1.3	-1.3
Heart attack/myocardial infarction (self-reported)	3.0	3.9	8.3	1.7	1.6	-0.7	2.2	2.1	2.9
Deep venous thrombosis (DVT) (self-reported)	1.7	2.2	9.0	3.0	0.5	-0.8	0.8	0.7	1.4
Heart disease (siblings)	3.7	4.5	11.7	3.4	1.4	-1.1	2.0	1.8	2.2
Alcohol drinker status: Previous	0.5	0.5	2.0	0.0	-1.4	0.8	0.3	0.0	0.7
Pack years of smoking	0.2	0.4	1.2	1.1	0.2	0.3	0.5	0.3	0.7
Impedance of whole body	0.2	0.8	2.3	-0.6	-0.3	1.1	-0.7	-1.5	-0.7
Leg fat mass (left)	0.2	0.9	1.7	1.3	-0.1	-0.0	1.0	1.3	1.1
Arm predicted mass (left)	0.3	1.6	6.2	-0.3	-2.5	1.7	0.2	0.5	0.5