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chr8:21,297,645-24,094,711

Best TWAS P=1.41e-30 · Best GWAS P=8.95e-34 conditioned to 0.0039

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
57	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C8orf58	0.04	0.01	blup	69	0.02	2.9e-03	8.64	11.5	1.4e-30	0.71	0.03	0.93	TRUE
37	GTEx	Thyroid	C8orf58	0.07	0.03	lasso	2	0.03	3.0e-03	9.13	8.7	2.5e-18	0.50	0.75	0.04	TRUE
60	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC25A37	0.04	0.02	lasso	2	0.03	1.1e-04	-5.69	-6.1	1.2e-09	0.02	0.01	0.92	TRUE
64	The Cancer Genome Atlas	Lung Adenocarcinoma	FGF17	0.08	0.03	blup	45	0.05	4.4e-06	-2.29	5.6	1.9e-08	0.04	0.00	1.00	TRUE
26	GTEx	Nerve Tibial	REEP4	0.21	0.07	lasso	4	0.08	3.9e-06	5.37	5.5	4.7e-08	-0.02	0.98	0.00	TRUE
67	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C8orf58	0.05	0.06	lasso	4	0.03	2.1e-03	9.79	11.0	3.0e-28	0.72	0.07	0.65	FALSE
46	ROSMAP	Brain Pre-frontal Cortex	C8orf58	0.15	0.18	lasso	5	0.18	7.6e-23	9.70	10.7	1.4e-26	0.63	1.00	0.00	FALSE
52	The Cancer Genome Atlas	Breast Invasive Carcinoma	C8orf58	0.04	0.04	blup	71	0.05	1.7e-10	9.74	10.5	5.7e-26	0.63	1.00	0.00	FALSE
6	GTEx	Adipose Visceral Omentum	BIN3	0.09	0.10	lasso	2	0.06	5.5e-04	10.16	10.5	9.6e-26	0.58	0.09	0.84	FALSE
72	The Cancer Genome Atlas	Thyroid Carcinoma	C8orf58	0.06	0.09	blup	69	0.09	4.8e-09	9.01	10.4	2.6e-25	0.63	1.00	0.00	FALSE
53	The Cancer Genome Atlas	Breast Invasive Carcinoma	PDLIM2	0.04	0.01	enet	13	0.03	3.2e-06	9.74	-10.1	8.7e-24	-0.55	0.50	0.30	FALSE
51	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C8orf58	0.04	0.05	blup	69	0.04	1.7e-04	9.70	10.0	1.7e-23	0.59	0.63	0.10	FALSE
45	ROSMAP	Brain Pre-frontal Cortex	CCAR2	0.11	0.08	lasso	6	0.07	1.8e-09	10.16	-9.9	5.3e-23	-0.53	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PDLIM2	0.08	0.06	enet	11	0.06	8.9e-08	10.16	-9.9	6.5e-23	-0.54	1.00	0.00	FALSE
61	The Cancer Genome Atlas	Brain Lower Grade Glioma	C8orf58	0.11	0.18	lasso	4	0.17	4.9e-19	9.74	9.8	7.9e-23	0.54	1.00	0.00	FALSE
63	The Cancer Genome Atlas	Lung Adenocarcinoma	C8orf58	0.05	0.06	lasso	3	0.05	2.1e-06	9.85	9.8	8.6e-23	0.52	0.97	0.00	FALSE
27	GTEx	Nerve Tibial	C8orf58	0.14	0.10	lasso	6	0.11	2.7e-08	9.85	9.8	8.7e-23	0.53	0.98	0.01	FALSE
69	The Cancer Genome Atlas	Prostate Adenocarcinoma	C8orf58	0.07	0.11	lasso	2	0.10	5.6e-11	9.51	9.8	1.7e-22	0.50	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	BIN3	0.11	0.10	enet	11	0.10	1.4e-08	9.68	9.7	2.0e-22	0.51	1.00	0.00	FALSE
56	The Cancer Genome Atlas	Colon Adenocarcinoma	FLJ14107	0.05	0.04	blup	66	0.04	1.8e-03	9.13	9.7	2.6e-22	0.52	0.03	0.75	FALSE
16	GTEx	Cells Transformed fibroblasts	C8orf58	0.36	0.42	lasso	7	0.47	3.6e-39	9.65	9.7	3.3e-22	0.53	1.00	0.00	FALSE
73	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	BIN3	0.40	0.10	blup	97	0.12	3.7e-04	12.00	9.7	3.5e-22	0.68	0.00	0.89	FALSE
23	GTEx	Muscle Skeletal	CCAR2	0.06	0.02	enet	7	0.01	2.7e-02	9.85	9.6	6.9e-22	0.51	0.91	0.00	FALSE
32	GTEx	Skin Sun Exposed Lower leg	CCAR2	0.11	0.09	lasso	5	0.10	1.7e-08	9.31	9.6	1.1e-21	0.50	1.00	0.00	FALSE
17	GTEx	Cells Transformed fibroblasts	RP11-582J16.5	0.11	0.10	lasso	4	0.09	2.0e-07	9.31	-9.5	2.8e-21	-0.48	0.96	0.03	FALSE
70	The Cancer Genome Atlas	Soft Tissue Sarcoma	BIN3	0.05	0.02	blup	96	0.02	2.0e-02	7.76	9.5	2.8e-21	0.50	0.12	0.06	FALSE
54	The Cancer Genome Atlas	Colon Adenocarcinoma	C8orf58	0.11	0.03	blup	69	0.04	2.5e-03	9.38	9.4	4.9e-21	0.49	0.49	0.04	FALSE
36	GTEx	Thyroid	CCAR2	0.17	0.12	lasso	5	0.12	9.5e-10	9.51	9.3	1.4e-20	0.48	1.00	0.00	FALSE
5	GTEx	Adipose Subcutaneous	C8orf58	0.09	0.03	lasso	3	0.01	6.2e-02	8.82	9.2	4.3e-20	0.44	0.42	0.05	FALSE
68	The Cancer Genome Atlas	Prostate Adenocarcinoma	BIN3	0.02	0.01	blup	97	0.01	3.4e-02	9.70	9.1	1.2e-19	0.49	0.30	0.03	FALSE
22	GTEx	Lung	CCAR2	0.11	0.07	enet	11	0.08	2.0e-06	8.11	9.1	1.3e-19	0.48	0.99	0.00	FALSE
35	GTEx	Thyroid	BIN3	0.17	0.12	lasso	4	0.12	2.1e-09	8.34	9.0	1.7e-19	0.50	1.00	0.00	FALSE
28	GTEx	Ovary	BIN3	0.38	0.24	lasso	5	0.30	4.0e-08	8.82	9.0	2.1e-19	0.42	0.81	0.01	FALSE
8	GTEx	Artery Aorta	BIN3	0.11	0.07	lasso	3	0.06	2.1e-04	8.34	9.0	2.2e-19	0.49	0.82	0.02	FALSE
29	GTEx	Skin Not Sun Exposed Suprapubic	BIN3	0.09	0.09	lasso	2	0.08	2.5e-05	7.76	9.0	2.2e-19	0.46	0.71	0.08	FALSE
13	GTEx	Cells EBV-transformed lymphocytes	CCAR2	0.20	0.05	lasso	3	0.03	3.1e-02	7.94	9.0	2.3e-19	0.48	0.26	0.04	FALSE
55	The Cancer Genome Atlas	Colon Adenocarcinoma	EGR3	0.07	0.03	blup	56	0.04	1.4e-03	9.72	9.0	2.3e-19	0.44	0.00	0.89	FALSE
65	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C8orf58	0.02	0.01	blup	69	0.02	4.9e-03	9.01	9.0	3.4e-19	0.55	0.17	0.10	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	CCAR2	0.11	0.08	lasso	4	0.05	8.8e-04	8.82	8.9	5.8e-19	0.44	0.91	0.01	FALSE
48	ROSMAP	Brain Pre-frontal Cortex	CTD-3247F14.2	0.10	0.12	lasso	3	0.12	1.5e-14	9.04	8.9	5.9e-19	0.44	1.00	0.00	FALSE
31	GTEx	Skin Sun Exposed Lower leg	BIN3	0.13	0.14	lasso	4	0.16	7.6e-13	8.34	8.8	1.2e-18	0.48	1.00	0.00	FALSE
25	GTEx	Nerve Tibial	CCAR2	0.09	0.08	lasso	4	0.08	3.7e-06	7.94	8.8	1.7e-18	0.47	0.96	0.01	FALSE
34	GTEx	Testis	C8orf58	0.25	0.09	enet	12	0.10	2.2e-05	9.13	-8.8	1.7e-18	-0.47	0.79	0.06	FALSE
4	GTEx	Adipose Subcutaneous	CCAR2	0.15	0.14	enet	26	0.13	6.9e-11	9.13	8.8	1.9e-18	0.49	1.00	0.00	FALSE
21	GTEx	Lung	BIN3	0.21	0.12	enet	25	0.14	7.9e-11	9.13	8.6	7.1e-18	0.53	1.00	0.00	FALSE
71	The Cancer Genome Atlas	Thyroid Carcinoma	BIN3	0.07	0.04	lasso	5	0.05	2.5e-05	8.39	8.6	7.3e-18	0.49	0.87	0.00	FALSE
47	ROSMAP	Brain Pre-frontal Cortex	RP11-582J16.5	0.32	0.43	lasso	11	0.46	5.3e-66	9.34	-8.5	1.8e-17	-0.42	1.00	0.00	FALSE
19	GTEx	Esophagus Mucosa	BIN3	0.13	0.09	lasso	3	0.10	5.4e-07	8.39	8.5	2.7e-17	0.46	0.99	0.00	FALSE
18	GTEx	Colon Transverse	BIN3	0.17	0.12	lasso	1	0.09	4.8e-05	8.39	8.4	4.7e-17	0.46	0.38	0.05	FALSE
9	GTEx	Artery Tibial	BIN3	0.13	0.09	lasso	2	0.08	1.0e-06	8.34	8.3	7.2e-17	0.46	0.89	0.07	FALSE
43	ROSMAP	Brain Pre-frontal Cortex	BIN3	0.27	0.38	lasso	2	0.38	7.2e-52	8.34	8.3	7.2e-17	0.46	1.00	0.00	FALSE
33	GTEx	Stomach	BIN3	0.17	0.00	enet	9	0.02	3.4e-02	8.34	8.3	7.3e-17	0.46	0.28	0.10	FALSE
41	METSIM	Adipose	C8orf58	0.04	0.02	enet	13	0.02	1.1e-03	10.03	8.3	1.0e-16	0.51	0.93	0.00	FALSE
11	GTEx	Breast Mammary Tissue (Male)	BIN3	0.22	0.00	lasso	4	-0.01	6.5e-01	8.80	8.3	1.2e-16	0.42	0.08	0.08	FALSE
39	GTEx	Whole Blood	C8orf58	0.05	0.03	lasso	4	0.02	5.5e-03	8.11	8.2	2.9e-16	0.45	0.25	0.12	FALSE
12	GTEx	Breast Mammary Tissue (Female)	BIN3	0.03	0.00	lasso	2	0.02	7.6e-02	8.11	8.1	7.7e-16	0.45	0.05	0.05	FALSE
62	The Cancer Genome Atlas	Lung Adenocarcinoma	BIN3	0.04	0.03	lasso	4	0.04	3.6e-05	7.58	7.8	6.5e-15	0.39	0.72	0.02	FALSE
14	GTEx	Cells Transformed fibroblasts	BIN3	0.26	0.12	lasso	7	0.16	2.4e-12	8.34	7.8	7.2e-15	0.44	1.00	0.00	FALSE
24	GTEx	Muscle Skeletal	C8orf58	0.05	0.04	enet	13	0.04	1.1e-04	9.31	7.7	1.1e-14	0.48	0.73	0.06	FALSE
10	GTEx	Brain Cerebellar Hemisphere	SORBS3	0.23	0.11	lasso	6	0.12	4.4e-04	9.38	7.7	1.4e-14	0.40	0.14	0.05	FALSE
40	METSIM	Adipose	BIN3	0.07	0.06	enet	12	0.06	5.6e-09	8.34	7.6	2.9e-14	0.48	1.00	0.00	FALSE
7	GTEx	Adipose Visceral Omentum	CCAR2	0.22	0.03	lasso	3	0.01	1.0e-01	7.87	7.4	1.4e-13	0.40	0.08	0.58	FALSE
38	GTEx	Whole Blood	BIN3	0.06	0.01	enet	16	0.02	4.2e-03	9.13	7.3	2.1e-13	0.29	0.48	0.04	FALSE
20	GTEx	Esophagus Muscularis	BIN3	0.10	0.01	lasso	3	0.01	9.3e-02	-3.35	7.2	8.3e-13	0.49	0.24	0.07	FALSE
1	CommonMind	Brain Pre-frontal Cortex	C8orf58	0.09	0.06	bslmm	524	0.06	3.3e-08	8.39	7.1	1.2e-12	0.38	1.00	0.00	FALSE
59	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C8orf58	0.04	0.03	blup	69	0.04	3.2e-05	9.69	7.0	2.8e-12	0.45	0.89	0.01	FALSE
42	NTR	Blood	BIN3	0.03	0.00	blup	540	0.00	7.5e-02	1.16	6.5	9.8e-11	0.25	0.07	0.02	FALSE
49	YFS	Blood	KIAA1967	0.05	0.04	bslmm	505	0.04	2.4e-12	7.58	6.4	2.1e-10	0.35	1.00	0.00	FALSE
58	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC25A37	0.11	0.09	lasso	5	0.09	7.8e-10	-5.69	-5.7	1.1e-08	0.01	0.00	1.00	FALSE
66	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PEBP4	0.07	0.02	blup	192	0.02	1.7e-03	-0.31	-5.5	3.1e-08	-0.28	0.02	0.76	FALSE
44	ROSMAP	Brain Pre-frontal Cortex	SLC25A37	0.27	0.36	enet	12	0.37	1.5e-49	5.11	-5.4	6.9e-08	0.04	0.16	0.83	FALSE
50	YFS	Blood	REEP4	0.12	0.09	bslmm	429	0.09	8.2e-28	4.97	5.3	1.1e-07	0.01	1.00	0.00	FALSE
15	GTEx	Cells Transformed fibroblasts	SLC25A37	0.13	0.05	lasso	5	0.04	3.0e-04	-3.64	5.1	2.8e-07	0.01	0.02	0.98	FALSE